MCID: INT075
MIFTS: 59

Intracranial Hypertension malady

Summaries for Intracranial Hypertension

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43NINDS, 63Wikipedia, 32MalaCards
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NINDS:43 Pseudotumor cerebri literally means "false brain tumor." It is likely due to high pressure within the skull caused by the buildup or poor absorption of cerebrospinal fluid (CSF). The disorder is most common in women between the ages of 20 and 50. Symptoms of pseudotumor cerebri, which include headache, nausea, vomiting, and pulsating sounds within the head, closely mimic symptoms of large brain tumors.

MalaCards: Intracranial Hypertension, also known as raised intracranial pressure, is related to hypertension and pseudotumor cerebri. An important gene associated with Intracranial Hypertension is TSC1 (tuberous sclerosis 1), and among its related pathways are Adipogenesis and Complement and coagulation cascades. The drugs thiopental and urea and the compounds hydrocortisone and heparin have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and ovary, and related mouse phenotypes are renal/urinary system and integument.

Wikipedia:63 Intracranial pressure (ICP) is the pressure inside the skull and thus in the brain tissue and... more...

Aliases & Classifications for Intracranial Hypertension

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8Disease Ontology, 43NINDS, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

intracranial hypertension 8 43 10 44 60
raised intracranial pressure 8


External Ids:

Disease Ontology8 DOID:9428
NCIt39 C84791
MeSH34 D019586

Related Diseases for Intracranial Hypertension

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Intracranial Hypertension via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 316)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension32.0ALB, SERPINE1, SLC12A3, LEP, F5, HSD11B1
2pseudotumor cerebri31.1SSTR1, RBP4
3obesity30.8HSD11B1, TNF, RBP4, LEP, SERPINE1
4intracranial thrombosis30.8APOH, F5, SERPINC1
5lupus erythematosus30.6APOH, F5, SERPINC1
6meningitis30.6CXCL10, IL1B, ALB
7systemic lupus erythematosus30.5CXCL10, RBP4, APOH, TNF
8migraine30.4CACNA1A, APOH, ATP1A2
9sagittal sinus thrombosis30.3F5, SERPINC1
10neuropathy30.3ALB, CACNA1A
11brain edema30.3AQP4, ALB
12hepatitis30.3RBP4, CXCL10, ALB
13meningioma30.2TSC1
14polycystic ovary syndrome30.2SERPINE1, LEP, RBP4, HSD11B1
15malaria30.2TNF, RBP4, ALB
16cadasil30.2APOH, F5, SERPINE1, SERPINC1, AQP4
17polyneuropathy30.1RBP4
18nephrotic syndrome30.1ALB, SERPINC1, RBP4
19encephalitis30.1AQP4, IL1B, CXCL10
20leukemia30.1TNF, RBP4, IL1B
21peritonitis30.1TNF, IL1B, ALB
22sjogren's syndrome29.9APOH
23hypothyroidism29.9LEP
24hyperthyroidism29.9LEP
25glaucoma29.9AQP4, HSD11B1
26hepatic encephalopathy29.9ALB, AQP4
27antiphospholipid syndrome29.9SERPINC1, F5, APOH
28hyperandrogenism29.9LEP
29myeloma29.9ALB, IL1B
30adenoma29.9TSC1, LAMC2, SSTR1, HSD11B1
31prostate cancer29.9SSTR1, CXCL10, LAMC2, TWIST1
32protein c deficiency29.9APOH, F5, SERPINE1, SERPINC1
33thrombophilia29.9APOH, F5, SERPINE1, SERPINC1
34adult respiratory distress syndrome29.9TNF, F5, IL1B
35astrocytoma29.9AQP4, TSC1, IL1B, CXCL10
36vascular disease29.9APOH, F5, SERPINE1, SERPINC1
37essential hypertension29.9LEP, SLC12A3, SERPINE1, ALB
38papilledema10.8
39cerebritis10.7
40intracranial sinus thrombosis10.5
41hydrocephalus10.4
42choroiditis10.4
43intracranial hypotension10.3
44adrenoleukodystrophy10.3
45hypervitaminosis a10.3
46synostosis10.3
47arachnoiditis10.2
48empty sella syndrome10.2
49ocular hypertension10.2
50malignant hypertension10.2

Graphical network of the top 20 diseases related to Intracranial Hypertension:



Diseases related to intracranial hypertension

Clinical Features for Intracranial Hypertension

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Drugs & Therapeutics for Intracranial Hypertension

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Intracranial Hypertension

Drug clinical trials:

Search ClinicalTrials for Intracranial Hypertension

Search NIH Clinical Center for Intracranial Hypertension

Search CenterWatch for Intracranial Hypertension

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Intracranial Hypertension

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Anatomical Context for Intracranial Hypertension

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32MalaCards
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MalaCards organs/tissues related to Intracranial Hypertension:

32
Brain, Liver, Ovary, Heart, Eye, Spinal cord, Testes, Kidney, Thyroid, Prostate

Animal Models for Intracranial Hypertension or affiliated genes

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36MGI
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Publications for Intracranial Hypertension

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50PubMed
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Articles related to Intracranial Hypertension:

(show top 50)    (show all 638)
idTitleAuthorsYear
1
Epidemiology and risk factors for idiopathic intracranial hypertension. (24296367)
2014
2
Cerebrospinal fluid diversion procedures in the treatment of patients with idiopathic intracranial hypertension. (24296371)
2014
3
Increased levels of interleukins 2 and 17 in the cerebrospinal fluid of patients with idiopathic intracranial hypertension. (24179731)
2013
4
The obesity pattern of idiopathic intracranial hypertension in men. (23955783)
2013
5
Pediatric idiopathic intracranial hypertension: a need for clarification. (23958286)
2013
6
Idiopathic intracranial hypertension; research progress and emerging themes. (24085346)
2013
7
Idiopathic intracranial hypertension in pediatric population: case series from India. (24262450)
2013
8
Relevance of intracranial hypertension control in the management of Cryptococcus neoformans meningitis related to AIDS. (24122543)
2013
9
Teaching NeuroImages: Subdural hematoma with pseudo-intracranial hypertension. (23267035)
2013
10
Clinical course of idiopathic intracranial hypertension with transverse sinus stenosis. (23269597)
2013
11
Idiopathic intracranial hypertension as the initial presentation of systemic lupus erythematosus. (23376664)
2013
12
Effects of indomethacin test on intracranial pressure and cerebral hemodynamics in patients with refractory intracranial hypertension: a feasibility study. (22531711)
2012
13
Therapeutic hypothermia for treatment of intractable intracranial hypertension after liver transplantation. (22210703)
2012
14
Dural sinus stent placement for idiopathic intracranial hypertension. (22149379)
2012
15
Pediatric idiopathic intracranial hypertension and extreme childhood obesity. (22633290)
2012
16
Effects of acute intracranial hypertension on extracerebral organs: a randomized experimental study in pigs. (22899228)
2012
17
A surgical technique for a terminal intracranial hypertension model in pigs. (22522418)
2012
18
MR imaging findings in patients with secondary intracranial hypertension. (21511864)
2011
19
Idiopathic intracranial hypertension. (21788420)
2011
20
Intracranial hypertension following intrathecal administration of liposomal cytarabine. (20706845)
2011
21
Brain hypoxia is associated with short-term outcome after severe traumatic brain injury independently of intracranial hypertension and low cerebral perfusion pressure. (21673608)
2011
22
Association of acute onset hypertension and tachycardia following intracisternal papaverine administration during intracranial aneurysm surgery: a case report and review of the literature. (21497075)
2011
23
Resolution of headache and papilledema in idiopathic intracranial hypertension associated with inhibition of Na+-K+-2Cl- cotransport. (21285039)
2011
24
Hypermagnesemia does not prevent intracranial hypertension and aggravates cerebral hyperperfusion in a rat model of acute hyperammonemia. (21384403)
2011
25
"Idiopathic" intracranial hypertension caused by venous sinus thrombosis associated with contraceptive usage. (20630373)
2010
26
Factors associated with intracranial hypertension in children and teenagers who suffered severe head injuries. (20151089)
2010
27
Correction: Addison's disease presenting with idiopathic intracranial hypertension in 24-year-old woman: a case report. (21078156)
2010
28
Hyperemic hydrocephalus: a new form of childhood hydrocephalus analogous to hyperemic intracranial hypertension in adults. (20043733)
2010
29
Idiopathic intracranial hypertension presenting as unilateral papilledema. (21045536)
2010
30
Effectiveness of ketamine in decreasing intracranial pressure in children with intracranial hypertension. (19569909)
2009
31
From pseudotumour cerebri to idiopathic intracranial hypertension. (19923117)
2009
32
L-ornithine phenylacetate attenuates increased arterial and extracellular brain ammonia and prevents intracranial hypertension in pigs with acute liver failure. (19554542)
2009
33
Functional visual loss in idiopathic intracranial hypertension. (19643491)
2009
34
Mild hypothermia (33 degrees C) reduces intracranial hypertension and improves functional outcome after subarachnoid hemorrhage in rats. (19625915)
2009
35
Anatibant, a selective non-peptide bradykinin B2 receptor antagonist, reduces intracranial hypertension and histopathological damage after experimental traumatic brain injury. (19429066)
2009
36
Optic nerve head drusen and idiopathic intracranial hypertension in a 14-year-old girl. (19645406)
2009
37
Surgical interventions for idiopathic intracranial hypertension. (19687737)
2009
38
Mannitol or hypertonic saline for intracranial hypertension? A point of view. (19485880)
2009
39
Acute intracranial hypertension increases gastric tonus in anesthetized rats. (19181574)
2009
40
J-wave formation in patients with acute intracranial hypertension. (19520383)
2009
41
Hemolytic anemia presenting with idiopathic intracranial hypertension. (18054695)
2008
42
Idiopathic intracranial hypertension in a child after hemodialysis. (18805366)
2008
43
Repeated dosing of 23.4% hypertonic saline for refractory intracranial hypertension. A case report. (22518235)
2008
44
Relationship of "dose" of intracranial hypertension to outcome in severe traumatic brain injury. (18826355)
2008
45
Pseudotumor cerebri - idiopathic intracranial hypertension in the pediatric population. (16816807)
2006
46
Benign intracranial hypertension and heterozygosity for factor V Leiden mutation]. (16045879)
2005
47
Surgical treatment of intracranial hypertension in encephalic cryptococcosis. (14635751)
2003
48
Idiopathic intracranial hypertension presenting as hemiplegic migraine. (12222727)
2002
49
Benign intracranial hypertension vs. intracranial arteriovenous malformation: a possible CT dilemma. (7282463)
1981
50
Microcirculatory changes during the evolution of papilledema. A five-stage fluorescein angiographic study of progressive swelling of optic disk in intractable intracranial hypertension. (5053697)
1972

Genetic Variations for Intracranial Hypertension

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Expression for genes affiliated with Intracranial Hypertension

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Intracranial Hypertension

Search GEO for disease gene expression data for Intracranial Hypertension.

Pathways for genes affiliated with Intracranial Hypertension

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Sources:
37NCBI BioSystems Database, 29KEGG, 53Reactome, 52R&D Systems, 51QIAGEN, 12EMD Millipore
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Pathways related to Intracranial Hypertension according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8TWIST1, SERPINE1, LEP
2
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9.8F5, SERPINE1, SERPINC1
3
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9.8F5, SERPINE1, SERPINC1
4
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9.7ALB, SERPINE1, F5
5
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9.6F5, LAMC2, SERPINE1, SERPINC1
6
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9.5IL1B, FOSB, TNF
7
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9.4TNF, CXCL10, IL1B, SERPINE1
89.4AQP4, IL1B, SSTR1, TNF
9
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9.4TNF, FOSB, RBP4, LEP
109.3TNF, IL1B, SERPINE1, ALB
119.3AQP4, LEP, IL1B, CXCL10, TNF
12
Hide members
9.3TNF, FOSB, IL1B, SERPINE1
13
Hide members
8.7CACNA1A, TNF, FOSB, CXCL10, IL1B, LAMC2

Compounds for genes affiliated with Intracranial Hypertension

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Sources:
44Novoseek, 2BitterDB, 59Tocris Bioscience, 11DrugBank, 28IUPHAR, 24HMDB, 49PharmGKB
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Compounds related to Intracranial Hypertension according to GeneCards/GeneDecks:

(show top 50)    (show all 125)
idCompoundScoreTop Affiliating Genes
1hydrocortisone44 2 59 1113.7HSD11B1
2heparin44 28 11 2413.6APOH
3estrogen4410.5HSD11B1, APOH
4dextran sulfate4410.5F5, APOH
5warfarin44 49 11 2413.4SERPINC1, APOH
6dexamethasone44 49 28 1113.4HSD11B1, AQP4, RBP4
7gabexate mesilate4410.4F5, SERPINC1
8rosiglitazone44 49 28 11 2414.3LEP, RBP4, HSD11B1
9alpha tocopherol4410.3APOH, RBP4
10uric acid44 2411.3APOH, F5, SERPINE1
11tacrolimus44 49 1112.3CXCL10, ALB
12endotoxin4410.3SERPINE1, APOH, F5
13glucose4410.3TSC1, APOH, RBP4, ATP1A2
14ancrod4410.2SERPINC1, SERPINE1, F5
15prednisolone44 28 1112.1HSD11B1, APOH
16hextend4410.1ALB, SERPINC1
17fatty acid4410.1HSD11B1, RBP4, ATP1A2, APOH
18kininogen4410.1SERPINC1, SERPINE1, F5, APOH
19taurine chloramine4410.0IL1B, F5, TNF
20sodium44 2411.0AQP4, CACNA1A, ATP1A2, HSD11B1
21tibolone4410.0LEP, SERPINE1, SERPINC1, F5
22glutamate4410.0CACNA1A, AQP4, APOH, ATP1A2
23gold449.9CXCL10, RBP4, APOH, LAMC2, AQP4
248-isoprostane449.9SERPINE1, TNF, LEP, APOH
25aminoguanidine44 28 1111.9IL1B, ALB, LEP
26infliximab44 49 1111.9CXCL10, APOH, TNF, IL1B
27etanercept44 49 1111.9LEP, IL1B, TNF, APOH
28hydrochlorothiazide44 49 28 11 2413.8SERPINE1, ALB, SLC12A3
29ivig449.8TNF, APOH, IL1B, ALB
30pioglitazone44 49 28 1112.7LEP, RBP4, TNF, SERPINE1, HSD11B1
31folate449.7APOH, RBP4, F5, SERPINC1, ALB
32p002449.7RBP4, APOH, F5, LEP
33homocysteine44 2410.7ALB, APOH, SERPINE1, SERPINC1, F5
34aspirin44 49 28 2412.7IL1B, SERPINC1, SERPINE1, APOH, F5
35creatinine449.6ALB, LEP, CXCL10, F5, RBP4, APOH
36polymyxin b449.6IL1B, TNF, SERPINE1
37ascorbic acid44 2410.5SERPINC1, RBP4, LEP, ALB, F5
38progesterone44 59 28 11 2413.4LEP, F5, SERPINE1, RBP4, HSD11B1, APOH
39troglitazone44 28 59 1112.4SERPINE1, LEP, IL1B, TNF
40methotrexate44 49 1111.3SERPINE1, TNF, APOH, ALB, IL1B, LEP
41prostacyclin449.2TNF, LEP, SERPINE1, SERPINC1, F5, APOH
42testosterone44 59 11 2412.2F5, LEP, SERPINC1, RBP4, HSD11B1, SERPINE1
43alanine449.2HSD11B1, RBP4, F5, SLC12A3, CXCL10, TSC1
44fibrinogen449.2LEP, APOH, ALB, SERPINC1, F5, SERPINE1
45cholesterol44 28 11 2412.1HSD11B1, CXCL10, F5, ALB, SERPINE1, APOH
46histamine44 28 2410.9TNF, CXCL10, IL1B, AQP4, ALB
47vegf448.9IL1B, TSC1, SERPINC1, SERPINE1, LEP, TNF
48lipid448.9TNF, APOH, HSD11B1, CXCL10, RBP4, LEP
49serine448.8TNF, CACNA1A, SSTR1, LEP, RBP4, SLC12A3
50calcium44 49 11 2411.2SSTR1, CXCL10, SLC12A3, ALB, ATP1A2, F5

GO Terms for genes affiliated with Intracranial Hypertension

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16Gene Ontology
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Cellular components related to Intracranial Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein complexGO:0432349.7AQP4, ALB, TSC1, RBP4
2platelet alpha granule lumenGO:0310939.4F5, SERPINE1, ALB
3extracellular spaceGO:0056158.1ALB, TNF, APOH, RBP4, F5, CXCL10
4extracellular regionGO:0055767.9TNF, RBP4, F5, CXCL10, IL1B, LEP

Biological processes related to Intracranial Hypertension according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of monocyte chemotactic protein-1 productionGO:07163910.3IL1B, TWIST1
2positive regulation of calcidiol 1-monooxygenase activityGO:06055910.2TNF, IL1B
3sequestering of triglycerideGO:03073010.1TNF, IL1B
4positive regulation of heterotypic cell-cell adhesionGO:03411610.1IL1B, TNF
5negative regulation of fibrinolysisGO:05191810.1SERPINE1, APOH
6response to insulin stimulusGO:03286810.1RBP4, LEP, TSC1
7positive regulation of fever generationGO:03162210.1IL1B, TNF
8positive regulation of chemokine biosynthetic processGO:04508010.0IL1B, TNF
9regulation of I-kappaB kinase/NF-kappaB cascadeGO:04312210.0IL1B, TNF
10leukocyte tethering or rollingGO:0509019.9LEP, TNF
11response to nutrientGO:0075849.8SSTR1, SERPINC1, ALB
12positive regulation of blood coagulationGO:0301949.8SERPINE1, APOH
13platelet degranulationGO:0025769.7F5, SERPINE1, ALB
14positive regulation of angiogenesisGO:0457669.7TWIST1, SERPINE1, IL1B
15regulation of insulin secretionGO:0507969.7LEP, IL1B, TNF, CACNA1A

Molecular functions related to Intracranial Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:0020209.7SERPINC1, SERPINE1, TNF

Products for genes affiliated with Intracranial Hypertension

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Sources for Intracranial Hypertension

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet