MCID: INT075
MIFTS: 50

Intracranial Hypertension malady

Categories: Neuronal diseases

Aliases & Classifications for Intracranial Hypertension

Aliases & Descriptions for Intracranial Hypertension:

Name: Intracranial Hypertension 12 51 52 42 14 69
Raised Intracranial Pressure 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9428
MeSH 42 D019586
NCIt 47 C84791
UMLS 69 C0151740

Summaries for Intracranial Hypertension

NINDS : 51 Pseudotumor cerebri literally means "false brain tumor." It is likely due to high pressure within the skull caused by the buildup or poor absorption of cerebrospinal fluid (CSF). The disorder is most common in women between the ages of 20 and 50. Symptoms of pseudotumor cerebri, which include headache, nausea, vomiting, and pulsating sounds within the head, closely mimic symptoms of large brain tumors.

MalaCards based summary : Intracranial Hypertension, also known as raised intracranial pressure, is related to influenza and capillary hemangioma, and has symptoms including bulging fontanelle An important gene associated with Intracranial Hypertension is AQP4 (Aquaporin 4), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Mannitol and Nicardipine have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and liver, and related phenotypes are homeostasis/metabolism and cardiovascular system

Related Diseases for Intracranial Hypertension

Diseases related to Intracranial Hypertension via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 318)
id Related Disease Score Top Affiliating Genes
1 influenza 29.5 F2 F3 SERPINC1
2 capillary hemangioma 29.3 F2 F3 MTHFR SERPINC1
3 adrenal adenoma 29.1 HSD11B1 SERPINE1 TNF
4 intracranial hypertension, idiopathic 12.4
5 craniosynostosis, type 1 10.9
6 craniosynostosis 3 10.9
7 craniosynostosis 4 10.9
8 craniosynostosis 6 10.9
9 craniosynostosis, type 2 10.9
10 neurocutaneous melanosis, somatic 10.8
11 papilledema 10.3
12 med13l syndrome 10.3 APOH F5
13 congenital insensitivity to pain with severe intellectual disability 10.3 F2 F5
14 achard thiers syndrome 10.3 APOH F5
15 hemarthrosis 10.3 F2 F3
16 cerebritis 10.3
17 miller-dieker lissencephaly syndrome 10.2 F2 SERPINC1
18 multiple familial trichoepithelioma 10.2 F5 MTHFR
19 may-hegglin anomaly 10.2 APOH F2 SERPINC1
20 stroke, ischemic 10.2 F2 F3 F5
21 freiberg's disease 10.2 F2 F3 SERPINC1
22 intussusception 10.2 IL1B TNF
23 chorioretinal scar 10.2 F2 F3 SERPINC1
24 mixed hepatoblastoma 10.2 F2 F3 SERPINC1
25 dmd-related dilated cardiomyopathy 10.2 F2 F3 SERPINC1
26 eagle syndrome 10.2 F2 F5 SERPINC1
27 brain injury 10.2
28 atrophic nonflaccid tympanic membrane 10.2 F2 F3 F5
29 muscular dystrophy-dystroglycanopathy , type a, 12 10.2 F3 IL1B
30 epstein-barr virus hepatitis 10.2 F2 F3 SERPINC1
31 stt3a-cdg and stt3b-cdg 10.2 F5 SERPINC1 SERPINE1
32 scn8a-related epilepsy with encephalopathy 10.2 F2 MTHFR
33 traumatic brain injury 10.2
34 inherited blood coagulation disease 10.2 F3 F5 SERPINE1
35 exophthalmic ophthalmoplegia 10.2 APOH F5 SERPINC1
36 periosteal chondrosarcoma 10.2 F2 SERPINC1 SERPINE1
37 hennekam lymphangiectasia-lymphedema syndrome 2 10.2 F2 F3 SERPINC1
38 thyroid cancer, anaplastic 10.2 APOH F3 SERPINE1
39 trichomalacia 10.2 APOH AQP4 TNF
40 gastric dilatation 10.2 APOH AQP4 TNF
41 secretory diarrhea myopathy and deafness 10.2 F3 SERPINC1 SERPINE1
42 sertoli cell tumor 10.2 F3 SERPINC1
43 monocular exotropia 10.2 F3 SERPINC1 SERPINE1
44 vulvitis 10.2 F2 F3 SERPINE1
45 zika virus congenital syndrome 10.2 F3 SERPINC1 SERPINE1
46 myeloproliferative neoplasm 10.2 F2 F3 SERPINC1
47 alpha-2-macroglobulin deficiency 10.2 F2 F3
48 lung cancer 10.2 APOH F5 MTHFR
49 hereditary endotheliopathy, retinopathy, nephropathy, and stroke 10.2 F3 SERPINC1
50 tau syndrome 10.2 IL1B TNF

Graphical network of the top 20 diseases related to Intracranial Hypertension:



Diseases related to Intracranial Hypertension

Symptoms & Phenotypes for Intracranial Hypertension

UMLS symptoms related to Intracranial Hypertension:


bulging fontanelle

MGI Mouse Phenotypes related to Intracranial Hypertension:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.28 APOH AQP1 AQP4 CXCL10 F2 F3
2 cardiovascular system MP:0005385 10.27 AQP1 AQP4 CXCL10 F2 F3 F5
3 hematopoietic system MP:0005397 10.17 F2 F3 F9 HSD11B1 IL1B SERPINC1
4 immune system MP:0005387 10.07 TNF AQP4 CXCL10 F2 F3 F9
5 mortality/aging MP:0010768 9.97 APOH AQP1 AQP4 CXCL10 F2 F3
6 integument MP:0010771 9.92 F2 F3 F5 HSD11B1 IL1B MTHFR
7 liver/biliary system MP:0005370 9.73 F5 F9 HSD11B1 SERPINC1 SERPINE1 TNF
8 nervous system MP:0003631 9.7 F3 F5 HSD11B1 IL1B MTHFR SERPINC1
9 respiratory system MP:0005388 9.17 AQP1 AQP4 F2 F3 HSD11B1 SERPINE1

Drugs & Therapeutics for Intracranial Hypertension

Drugs for Intracranial Hypertension (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 261)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mannitol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 69-65-8 453 6251
2
Nicardipine Approved Phase 4,Phase 3,Phase 1 55985-32-5 4474
3
Histamine Approved, Investigational Phase 4,Phase 2 75614-87-8, 51-45-6 774
4
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3,Phase 2 76631-46-4, 113775-47-6 68602 5311068 56032
5
Clevidipine Approved Phase 4,Phase 3,Phase 2 167221-71-8
6
Morphine Approved, Investigational Phase 4 57-27-2 5288826
7
Hydralazine Approved Phase 4,Phase 2 86-54-4 3637
8
Esmolol Approved Phase 4,Phase 3,Phase 1 103598-03-4, 81147-92-4 59768
9
Remifentanil Approved Phase 4 132875-61-7 60815
10 Parecoxib Approved Phase 4 198470-84-7
11
Labetalol Approved Phase 4,Phase 3,Phase 2 36894-69-6 3869
12
Cosyntropin Approved Phase 4 16960-16-0 16129617
13
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
14
Formaldehyde Approved, Vet_approved Phase 4 50-00-0 712
15
Minocycline Approved, Investigational Phase 4 10118-90-8 5281021
16
Isotretinoin Approved Phase 4 4759-48-2 5538 5282379
17
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
18
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
19
Lymecycline Approved Phase 4 992-21-2 5280963
20
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
21
Ginseng Approved, Nutraceutical Phase 4 50647-08-0
22
Butyric Acid Experimental Phase 4,Phase 2 107-92-6 264
23
Histamine Phosphate Phase 4,Phase 2 51-74-1 65513
24 Analgesics Phase 4,Phase 3,Phase 2
25 calcium channel blockers Phase 4,Phase 3,Phase 2,Phase 1
26 diuretics Phase 4,Phase 3,Phase 2,Phase 1
27 Adrenergic Agents Phase 4,Phase 3,Phase 2,Phase 1
28 Narcotics Phase 4,Phase 2
29 Natriuretic Agents Phase 4,Phase 3,Phase 2,Phase 1
30 Adrenergic Agonists Phase 4,Phase 3,Phase 2
31 Adrenergic alpha-2 Receptor Agonists Phase 4,Phase 3,Phase 2
32 Adrenergic alpha-Agonists Phase 4,Phase 3,Phase 2
33 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
34 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3
35 Histamine Antagonists Phase 4,Phase 2
36 Analgesics, Opioid Phase 4,Phase 2
37 Anesthetics Phase 4,Phase 2,Phase 3
38 Anesthetics, General Phase 4,Phase 3,Phase 2
39 Anesthetics, Intravenous Phase 4,Phase 3,Phase 2
40 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Early Phase 1
41 Vasodilator Agents Phase 4,Phase 3,Phase 2,Phase 1
42 Pharmaceutical Solutions Phase 4,Phase 2,Phase 3,Phase 1
43 Hypnotics and Sedatives Phase 4,Phase 3,Phase 2
44 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3
45 Antihypertensive Agents Phase 4,Phase 3,Phase 2,Phase 1
46 Calcium, Dietary Phase 4,Phase 3,Phase 2,Phase 1
47 Central Nervous System Depressants Phase 4,Phase 3,Phase 2
48 Adrenergic Antagonists Phase 4,Phase 3,Phase 2,Phase 1
49 Adrenergic beta-1 Receptor Antagonists Phase 4,Phase 3,Phase 1
50 Adrenergic beta-Antagonists Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 217)
id Name Status NCT ID Phase
1 Comparison of 20% Mannitol and 3% Hypertonic Saline for Cerebral Relaxation During Elective Supratentorial Craniotomies Unknown status NCT01745081 Phase 4
2 The Efficacy and Safety of Cleviprex in Ventriculostomy Patients Requiring IV Antihypertensive Therapy Unknown status NCT01042574 Phase 4
3 IV Double and Triple Concentrated Nicardipine for Stroke and ICH Unknown status NCT00325793 Phase 4
4 Mannitol Versus Hypertonic Saline Solution in the Treatment of Elevated Intracranial Pressure Completed NCT00447018 Phase 4
5 Correlation of Measured and Calculated Serum Osmolality During Hyperosmolar Drugs Infusion in Patients After Craniotomy Completed NCT02037815 Phase 4
6 Mannitol Improves Cerebral Oxygen Saturation Completed NCT02091180 Phase 4
7 Cosyntropin Versus Epidural Blood Patch (EBP) for Treatment of Treatment of Post Dural Puncture Headache Completed NCT02394457 Phase 4
8 A Post Marketing Surveillance Study for NutropinAq® in Adults With Growth Hormone Deficiency Completed NCT00455884 Phase 4
9 A Comparison of the Perioperative Hemodynamic Effects of Remifentanil and Esmolol in Intracranial Surgery Completed NCT01628562 Phase 4
10 A Pilot Study to Evaluate Efficacy and Safety of Clevidipine in Neurosurgical Patients Completed NCT00952081 Phase 4
11 Comparison of Dexmedetomidin and Remifentanil for the Effect on Airway Reflex and Hemodynamic Response During Emergence in Patients Undergoing Craniotomy Completed NCT01365923 Phase 4
12 Hemodynamic Responses to Tracheal Intubation Direct Laryngoscope and Videolaryngoscope in Elderly Patients Completed NCT02816775 Phase 4
13 Clinical Study on the Treatment of Hypertensive Intracerebral Hemorrhage With Panax Notoginseng Saponin Completed NCT02999048 Phase 4
14 Effect of Parecoxib on Post-craniotomy Pain Completed NCT00455117 Phase 4
15 Treatment of Intracranial Hypertension of Severe Tramatic Brain Injured Patients. Physiopathologic Effects of Neuromuscular Blocking Agents Recruiting NCT02404779 Phase 4
16 Antiacne Medications Pseudotumor Cerebri Recruiting NCT02149615 Phase 4
17 SOLFAMU Study of Nasal Brushing Collected OLFActory MUcosa Samples in the Diagnosis of Human Encephalopathies Recruiting NCT02951559 Phase 4
18 Effect of Total Intravenous Anaesthesia With Propofol on Postoperative Pain After Bilateral Third Molar Surgery Active, not recruiting NCT03058341 Phase 4
19 Comparison of 2 Doses of Mannitol on Post Traumatic Intracranial Hypertension and Cerebral Monitoring Terminated NCT00795587 Phase 4
20 Cerebral Hemodynamic Effects of Hypertonic Solutions in Severely Head-Injured Patients Terminated NCT00125229 Phase 4
21 Effect of Intrathoracic Pressure Regulation on Traumatic Brain Injury Terminated NCT01824589 Phase 4
22 ShuntCheck Accuracy in Detecting Shunt Obstruction Normal Pressure Hydrocephalus (NPH) Patients Withdrawn NCT00793416 Phase 4
23 The Effect of Clevidipine on Intracranial Pressure and Cerebral Perfusion Pressure (CCP) in Brain Injured Patients Withdrawn NCT01526876 Phase 4
24 The Evaluation of Clevidipine in Patients Requiring ICP Monitoring and IV Antihypertensive Therapy Withdrawn NCT01910532 Phase 4
25 Clinical Value of Noninvasive Intracranial Pressure Measurement Unknown status NCT02130219 Phase 2, Phase 3
26 The DECRA Trial: Early Decompressive Craniectomy in Patients With Severe Traumatic Brain Injury Unknown status NCT00155987 Phase 3
27 Randomized Trial of Erythropoietin During Cerebral Malaria Unknown status NCT00697164 Phase 2, Phase 3
28 Mannitol as Adjunct Therapy for Childhood Cerebral Malaria Unknown status NCT00113854 Phase 3
29 Efficacy Study of Hypothermia Plus Magnesium Sulphate(MgSO4) in the Management of Term and Near Term Babies With Hypoxic Ischemic Encephalopathy Unknown status NCT01646619 Phase 3
30 Idiopathic Intracranial Hypertension Treatment Trial Completed NCT01003639 Phase 2, Phase 3
31 Preventive Sodium Lactate and Traumatic Brain Injury Completed NCT00995683 Phase 2, Phase 3
32 Impact of Ventricular Catheter Used With Antimicrobial Agents on Patients With a Ventricular Catheter Completed NCT00286104 Phase 3
33 Anti-Oxidant Supplementation for the Prevention of Acute Mountain Sickness Completed NCT00664001 Phase 3
34 Stenting vs. Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis Completed NCT00576693 Phase 3
35 Clevidipine in the Treatment of Patients With Acute Hypertension and Intracerebral Hemorrhage (ACCELERATE) Completed NCT00666328 Phase 3
36 Esmolol Versus Dexmedetomidine During Intracranial Procedures Recruiting NCT02563288 Phase 3
37 Low Dose Aspirin in the Prevention of Preeclampsia in China Recruiting NCT02797249 Phase 3
38 Treatment Protocol for Hemophagocytic Lymphohistiocytosis 2004 Active, not recruiting NCT00426101 Phase 3
39 Continuous Hyperosomolar Therapy for Traumatic Brain-injured Patients Not yet recruiting NCT03143751 Phase 3
40 Darbepoetin Trial to Improve Red Cell Mass and Neuroprotection in Preterm Infants Not yet recruiting NCT03169881 Phase 3
41 Comparison of Effectiveness of Pentobarbital and Thiopental in Patients With Refractory Intracranial Hypertension Terminated NCT00622570 Phase 3
42 Mannitol vs HS to Treat ICHT After Severe TBI : Comparison on PtiO2 and Microdialysis Values Terminated NCT01028339 Phase 3
43 Sodium-Lactate and Traumatic Brain Injury Terminated NCT00319345 Phase 2, Phase 3
44 Hypertonic Saline vs. Mannitol for Elevated Intercranial Pressure Terminated NCT01111682 Phase 3
45 Normal Pressure Hydrocephalus Treatment by Acetazolamide Terminated NCT02163330 Phase 3
46 Clinical Trial of Growth Hormone in MPS I, II, and VI Terminated NCT00748969 Phase 2, Phase 3
47 Hypothermia in Children After Trauma Terminated NCT00222742 Phase 3
48 Induced Hypertension for Treatment of Delayed Cerebral Ischaemia After Aneurysmal Subarachnoid Haemorrhage Terminated NCT01613235 Phase 3
49 Induced Hypertension for Delayed Cerebral Ischaemia After Aneurysmal Subarachnoid Haemorrhage:a Feasibility Study Terminated NCT00841633 Phase 3
50 Antihypertensive Treatment of Acute Cerebral Hemorrhage-II Terminated NCT01176565 Phase 3

Search NIH Clinical Center for Intracranial Hypertension

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: intracranial hypertension

Genetic Tests for Intracranial Hypertension

Anatomical Context for Intracranial Hypertension

MalaCards organs/tissues related to Intracranial Hypertension:

39
Brain, Testes, Liver, Ovary, Spinal Cord, Heart, Eye

Publications for Intracranial Hypertension

Articles related to Intracranial Hypertension:

(show top 50) (show all 782)
id Title Authors Year
1
Role of vitamin A metabolism in IIH: Results from the idiopathic intracranial hypertension treatment trial. ( 28017254 )
2017
2
Very Low Prevalence of Intracranial Hypertension in Trigonocephaly. ( 28027242 )
2017
3
Shunt Surgery in Idiopathic Intracranial Hypertension Aided by Electromagnetic Navigation. ( 28088808 )
2017
4
Audio-Vestibular Findings in Increased Intracranial Hypertension Syndrome. ( 28084997 )
2017
5
Pediatric Intracranial Hypertension. ( 27940011 )
2017
6
Bariatric Surgery or Non-surgical Weight Loss for Idiopathic Intracranial Hypertension? A Systematic Review and Comparison of Meta-analyses. ( 27981458 )
2017
7
Pituitary Apoplexy Mimicking Bacterial Meningitis with Intracranial Hypertension. ( 27756666 )
2017
8
Discussion: Sleep Architecture Linked to Airway Obstruction and Intracranial Hypertension in Children with Syndromic Craniosynostosis. ( 27879597 )
2016
9
Cerebrospinal fluid rhinorrhea secondary to idiopathic intracranial hypertension: Long-term outcomes of endoscopic repairs. ( 27456599 )
2016
10
Idiopathic intracranial hypertension following surgical treatment of Cushing disease: case report and review of management strategies. ( 27633717 )
2016
11
Intracranial hypertension as the primary symptom of gastric signet-ring cell carcinoma: A case report and literature review. ( 27583897 )
2016
12
Intracranial Hypertension Is Painless! ( 27165920 )
2016
13
Fulminant idiopathic intracranial hypertension and venous stasis retinopathy resulting in severe bilateral visual impairment. ( 28009405 )
2016
14
Craniectomy for Traumatic Intracranial Hypertension. ( 28032968 )
2016
15
Craniectomy for Traumatic Intracranial Hypertension. ( 28032966 )
2016
16
Patient-Specific Thresholds and Doses of Intracranial Hypertension in Severe Traumatic Brain Injury. ( 27165889 )
2016
17
Prevalence of idiopathic intracranial hypertension and associated factors in obese children and adolescents. ( 27464033 )
2016
18
Letter regarding article: Cerebral venous etiology of intracranial hypertension and differentiation from idiopathic intracranial hypertension. ( 27450029 )
2016
19
Teaching NeuroImages: Meningoencephalocele and CSF leak in chronic idiopathic intracranial hypertension. ( 27906666 )
2016
20
Trial of Decompressive Craniectomy for Traumatic Intracranial Hypertension. ( 27602507 )
2016
21
Pseudotumor cerebri: What We Have Learned from the Idiopathic Intracranial Hypertension Treatment Trial. ( 27128512 )
2016
22
CSF Lumbar Drainage: A Safe Surgical Option in Refractory Intracranial Hypertension Associated with Acute Posttraumatic External Hydrocephalus. ( 27165877 )
2016
23
Vascular etiology of intracranial hypertension. ( 27450030 )
2016
24
Venous Sinus Stenting in Idiopathic Intracranial Hypertension: Results of a Prospective Trial. ( 27556959 )
2016
25
Idiopathic intracranial hypertension occurred after spinal surgery: report of two rare cases and systematic review of the literature. ( 27188182 )
2016
26
Evidence for potential involvement of pro-inflammatory adipokines in the pathogenesis of idiopathic intracranial hypertension. ( 27193133 )
2016
27
About Intracranial Hypertension in Pediatric Patients: Good News About Treatment...But What About the Role of Optic Nerve Sheath Diameter Measurement in the Diagnosis? ( 27387784 )
2016
28
Idiopathic intracranial hypertension. ( 27166118 )
2016
29
Pearls & Oy-sters: A rare presentation of chronic intracranial hypertension with concurrent deafness and blindness. ( 27432182 )
2016
30
Bilateral Petrous Apex Cephaloceles and Skull Base Attenuation in Setting of Idiopathic Intracranial Hypertension. ( 27525627 )
2016
31
Idiopathic Intracranial Hypertension (Pseudotumor Cerebri). ( 27602531 )
2016
32
Morphometric MRI changes in intracranial hypertension due to cerebral venous thrombosis: a retrospective imaging study. ( 27180083 )
2016
33
Anterior lamina cribrosa surface position in idiopathic intracranial hypertension and glaucoma. ( 27198638 )
2016
34
Predictors for venous sinus stent retreatment in patients with idiopathic intracranial hypertension. ( 27965382 )
2016
35
Fulminant idiopathic intracranial hypertension managed with oral acetazolamide. ( 27521679 )
2016
36
Dynamic Cerebrovascular and Intracranial Pressure Reactivity Assessment of Impaired Cerebrovascular Autoregulation in Intracranial Hypertension. ( 27165917 )
2016
37
Drag-Reducing Polymer Enhances Microvascular Perfusion in the Traumatized Brain with Intracranial Hypertension. ( 27165871 )
2016
38
Time to re-assess the treatment of idiopathic intracranial hypertension. ( 27178402 )
2016
39
Craniectomy for Traumatic Intracranial Hypertension. ( 27974032 )
2016
40
Stenting of the Lateral Sinus in Idiopathic Intracranial Hypertension According to the Type of Stenosis. ( 27218234 )
2016
41
Intracranial hypertension secondary to high dose cytosine arabinoside - A case study. ( 28011351 )
2016
42
Finite Element Model for Hydrocephalus and Idiopathic Intracranial Hypertension. ( 27165898 )
2016
43
Cortical astrogliosis and increased perivascular aquaporin-4 in idiopathic intracranial hypertension. ( 27188961 )
2016
44
Corticosteroids for the management of severe intracranial hypertension in meningoencephalitis caused by Cryptococcus gattii: A case report and review. ( 27818191 )
2016
45
Idiopathic Intracranial Hypertension in a Prepubertal Pediatric Japanese Patient Complicated by Severe Papilledema. ( 27065853 )
2016
46
Cisternostomy for Management of Intracranial Hypertension in Severe Traumatic Brain Injury; Case Report and Literature Review. ( 27540551 )
2016
47
Craniectomy for Traumatic Intracranial Hypertension. ( 28032965 )
2016
48
Regarding the Idiopathic Intracranial Hypertension Treatment Trial. ( 27472780 )
2016
49
Craniectomy for Traumatic Intracranial Hypertension. ( 27974031 )
2016
50
Anatomical Variations of the transverse-sigmoid sinus junction: Implications for endovascular treatment of idiopathic intracranial hypertension. ( 27161529 )
2016

Variations for Intracranial Hypertension

Expression for Intracranial Hypertension

Search GEO for disease gene expression data for Intracranial Hypertension.

Pathways for Intracranial Hypertension

Pathways related to Intracranial Hypertension according to GeneCards Suite gene sharing:

(show all 12)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.05 APOH F2 F3 F5 F9 SERPINC1
2
Show member pathways
12.58 F2 F3 F5 F9 SERPINC1
3
Show member pathways
11.99 F2 IL1B MTHFR SERPINE1 TNF
4 11.7 CXCL10 IL1B TNF
5
Show member pathways
11.64 F2 F3 F5 F9 SERPINC1 SERPINE1
6 11.63 AQP1 AQP4 CXCL10 IL1B TNF
7 11.62 F3 IL1B SERPINE1 TNF
8 11.27 CXCL10 IL1B TNF
9 11.24 F2 F3 F5 F9 SERPINC1 SERPINE1
10 11.04 IL1B MTHFR TNF
11 10.71 IL1B TNF
12 10.65 F2 F9

GO Terms for Intracranial Hypertension

Cellular components related to Intracranial Hypertension according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.81 APOH AQP1 F2 F3 F9 IL1B
2 extracellular region GO:0005576 9.65 APOH CXCL10 F2 F3 F5 F9
3 endoplasmic reticulum lumen GO:0005788 9.62 F2 F5 F9 SERPINC1
4 external side of plasma membrane GO:0009897 9.56 AQP4 CXCL10 F2 TNF
5 extracellular space GO:0005615 9.32 APOH CXCL10 F2 F3 F5 F9

Biological processes related to Intracranial Hypertension according to GeneCards Suite gene sharing:

(show all 27)
id Name GO ID Score Top Affiliating Genes
1 platelet degranulation GO:0002576 9.8 APOH F5 SERPINE1
2 cellular response to lipopolysaccharide GO:0071222 9.8 CXCL10 SERPINE1 TNF
3 positive regulation of angiogenesis GO:0045766 9.73 AQP1 F3 IL1B SERPINE1
4 blood circulation GO:0008015 9.67 CXCL10 F5 MTHFR
5 blood coagulation GO:0007596 9.65 F2 F3 F5 F9 SERPINC1
6 signal peptide processing GO:0006465 9.63 F2 F9
7 positive regulation of monocyte chemotaxis GO:0090026 9.62 CXCL10 SERPINE1
8 water transport GO:0006833 9.61 AQP1 AQP4
9 negative regulation of lipid catabolic process GO:0050995 9.61 IL1B TNF
10 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.6 IL1B TNF
11 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.59 IL1B TNF
12 negative regulation of blood coagulation GO:0030195 9.58 APOH SERPINE1
13 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.58 IL1B TNF
14 positive regulation of interleukin-8 production GO:0032757 9.58 IL1B SERPINE1 TNF
15 peptidyl-glutamic acid carboxylation GO:0017187 9.57 F2 F9
16 positive regulation of chemokine biosynthetic process GO:0045080 9.56 IL1B TNF
17 multicellular organismal water homeostasis GO:0050891 9.55 AQP1 AQP4
18 regulation of establishment of endothelial barrier GO:1903140 9.54 IL1B TNF
19 regulation of blood coagulation GO:0030193 9.54 APOH F2 SERPINC1
20 blood coagulation, extrinsic pathway GO:0007598 9.52 F3 F9
21 positive regulation of fever generation GO:0031622 9.51 IL1B TNF
22 blood coagulation, intrinsic pathway GO:0007597 9.5 APOH F2 F9
23 sequestering of triglyceride GO:0030730 9.48 IL1B TNF
24 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.46 IL1B TNF
25 positive regulation of blood coagulation GO:0030194 9.33 APOH F2 SERPINE1
26 negative regulation of fibrinolysis GO:0051918 9.13 APOH F2 SERPINE1
27 hemostasis GO:0007599 9.02 F2 F3 F5 F9 SERPINC1

Molecular functions related to Intracranial Hypertension according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.56 F2 F3 F5 F9
2 water channel activity GO:0015250 9.32 AQP1 AQP4
3 heparin binding GO:0008201 9.26 APOH CXCL10 F2 SERPINC1
4 water transmembrane transporter activity GO:0005372 9.16 AQP1 AQP4
5 protease binding GO:0002020 8.92 F3 SERPINC1 SERPINE1 TNF

Sources for Intracranial Hypertension

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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