MCID: INT075
MIFTS: 59

Intracranial Hypertension malady

Summaries for Intracranial Hypertension

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43NINDS, 63Wikipedia, 32MalaCards
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NINDS:43 Pseudotumor cerebri literally means "false brain tumor." It is likely due to high pressure within the skull caused by the buildup or poor absorption of cerebrospinal fluid (CSF). The disorder is most common in women between the ages of 20 and 50. Symptoms of pseudotumor cerebri, which include headache, nausea, vomiting, and pulsating sounds within the head, closely mimic symptoms of large brain tumors.

MalaCards: Intracranial Hypertension, also known as raised intracranial pressure, is related to hypertension and pseudotumor cerebri. An important gene associated with Intracranial Hypertension is TSC1 (tuberous sclerosis 1), and among its related pathways are Adipogenesis and Complement and coagulation cascades. The drugs thiopental and urea and the compounds hydrocortisone and heparin have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and ovary, and related mouse phenotypes are renal/urinary system and integument.

Wikipedia:63 Intracranial pressure (ICP) is the pressure inside the skull and thus in the brain tissue and... more...

Aliases & Classifications for Intracranial Hypertension

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8Disease Ontology, 43NINDS, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

intracranial hypertension 8 43 10 44 60
raised intracranial pressure 8


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Disease Ontology8 DOID:9428
NCIt39 C84791
MeSH34 D019586

Related Diseases for Intracranial Hypertension

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Intracranial Hypertension via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 316)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension32.0ALB, SERPINE1, SLC12A3, LEP, F5, HSD11B1
2pseudotumor cerebri31.1SSTR1, RBP4
3obesity30.8HSD11B1, TNF, RBP4, LEP, SERPINE1
4intracranial thrombosis30.8APOH, F5, SERPINC1
5lupus erythematosus30.6APOH, F5, SERPINC1
6meningitis30.6CXCL10, IL1B, ALB
7systemic lupus erythematosus30.5CXCL10, RBP4, APOH, TNF
8migraine30.4CACNA1A, APOH, ATP1A2
9sagittal sinus thrombosis30.3F5, SERPINC1
10neuropathy30.3ALB, CACNA1A
11brain edema30.3AQP4, ALB
12hepatitis30.3RBP4, CXCL10, ALB
13meningioma30.2TSC1
14polycystic ovary syndrome30.2SERPINE1, LEP, RBP4, HSD11B1
15malaria30.2TNF, RBP4, ALB
16cadasil30.2APOH, F5, SERPINE1, SERPINC1, AQP4
17polyneuropathy30.1RBP4
18nephrotic syndrome30.1ALB, SERPINC1, RBP4
19encephalitis30.1AQP4, IL1B, CXCL10
20leukemia30.1TNF, RBP4, IL1B
21peritonitis30.1TNF, IL1B, ALB
22sjogren's syndrome29.9APOH
23hypothyroidism29.9LEP
24hyperthyroidism29.9LEP
25glaucoma29.9AQP4, HSD11B1
26hepatic encephalopathy29.9ALB, AQP4
27antiphospholipid syndrome29.9SERPINC1, F5, APOH
28hyperandrogenism29.9LEP
29myeloma29.9ALB, IL1B
30adenoma29.9TSC1, LAMC2, SSTR1, HSD11B1
31prostate cancer29.9SSTR1, CXCL10, LAMC2, TWIST1
32protein c deficiency29.9APOH, F5, SERPINE1, SERPINC1
33thrombophilia29.9APOH, F5, SERPINE1, SERPINC1
34adult respiratory distress syndrome29.9TNF, F5, IL1B
35astrocytoma29.9AQP4, TSC1, IL1B, CXCL10
36vascular disease29.9APOH, F5, SERPINE1, SERPINC1
37essential hypertension29.9LEP, SLC12A3, SERPINE1, ALB
38papilledema10.8
39cerebritis10.7
40intracranial sinus thrombosis10.5
41hydrocephalus10.4
42choroiditis10.4
43intracranial hypotension10.3
44adrenoleukodystrophy10.3
45hypervitaminosis a10.3
46synostosis10.3
47arachnoiditis10.2
48empty sella syndrome10.2
49ocular hypertension10.2
50malignant hypertension10.2

Graphical network of the top 20 diseases related to Intracranial Hypertension:



Diseases related to intracranial hypertension

Clinical Features for Intracranial Hypertension

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Drugs & Therapeutics for Intracranial Hypertension

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Intracranial Hypertension

Drug clinical trials:

Search ClinicalTrials for Intracranial Hypertension

Search NIH Clinical Center for Intracranial Hypertension

Search CenterWatch for Intracranial Hypertension

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Intracranial Hypertension

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Anatomical Context for Intracranial Hypertension

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32MalaCards
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MalaCards organs/tissues related to Intracranial Hypertension:

32
Brain, Liver, Ovary, Heart, Eye, Spinal cord, Testes, Kidney, Thyroid, Prostate

Animal Models for Intracranial Hypertension or affiliated genes

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36MGI
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Publications for Intracranial Hypertension

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50PubMed
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Articles related to Intracranial Hypertension:

(show top 50)    (show all 638)
idTitleAuthorsYear
1
A survey of routine treatment of patients with intracranial hypertension (ICH) in specialized trauma centers in Sao Paulo, Brazil: A 11 million metropole! (24388507)
2014
2
Venous hypertension as the cause of intracranial hypertension in patients with transverse sinus dural arteriovenous fistula. (22495458)
2013
3
Can ocular ultrasound predict intracranial hypertension? A pilot diagnostic accuracy evaluation in a UK emergency department. (22327166)
2013
4
Delayed intracranial hypertension after cranial vault remodeling for nonsyndromic single-suture synostosis. (23581636)
2013
5
Chronic inflammatory demyelinating polyradiculoneuropathy associated intracranial hypertension. (22941356)
2013
6
Idiopathic intracranial hypertension and pregnancy. (23563883)
2013
7
Symptomatic intracranial hypertension and prolonged hypocalcemia following treatment of Paget's disease of the skull with zoledronic acid. (23076294)
2013
8
Refractory intracranial hypertension due to fentanyl administration following closed head injury. (23372564)
2013
9
Intracranial hypertension and pulmonary hypertension. Causality or coincidence? (24269419)
2013
10
A patient with low pressure idiopathic intracranial hypertension and multiple cranial neuropathies. (24326719)
2013
11
Headache prevalence and clinical features in patients with idiopathic intracranial hypertension (IIH). (23695067)
2013
12
The use of acetazolamide during pregnancy in intracranial hypertension patients. (22635167)
2013
13
Posttraumatic Refractory Intracranial Hypertension and Brain Herniation Syndrome: Cerebral Hemodynamic Assessment before Decompressive Craniectomy. (24377095)
2013
14
Safety and Efficacy of Repeated Doses of 14.6 or 23.4A % Hypertonic Saline for Refractory Intracranial Hypertension. (24026522)
2013
15
Delayed intracranial hypertension and cerebral edema in severe pediatric head injury: risk factor analysis. (23571484)
2012
16
Rating papilloedema: an evaluation of the FrisAcn classification in idiopathic intracranial hypertension. (22237821)
2012
17
Multiple acquired encephaloceles: dramatic end point of chronic untreated intracranial hypertension in multi-suture craniosynostosis. (23920352)
2012
18
Pediatric idiopathic intracranial hypertension and extreme childhood obesity: a comment on visual outcomes. (22959139)
2012
19
The analysis of allodynia in patients with idiopathic intracranial hypertension. (22875880)
2012
20
Space obstructive syndrome: intracranial hypertension, intraocular pressure, and papilledema in space. (22272520)
2012
21
Proteomic analysis of cerebrospinal fluid from obese women with idiopathic intracranial hypertension: a new approach for identifying new candidates in the pathogenesis of obesity. (22296024)
2012
22
Hypertonic saline, not mannitol, should be considered gold-standard medical therapy for intracranial hypertension. (22353146)
2012
23
Response to intracranial hypertension treatment as a predictor of death in patients with severe traumatic brain injury. (21214327)
2011
24
Gliomatosis cerebri presenting as idiopathic intracranial hypertension in a child. (21566531)
2011
25
Idiopathic intracranial hypertension. (21063921)
2011
26
Primary spontaneous cerebrospinal fluid rhinorrhea: a symptom of idiopathic intracranial hypertension? (21476806)
2011
27
Weight gain and recurrence in idiopathic intracranial hypertension: a case-control study. (21536635)
2011
28
Management of idiopathic intracranial hypertension in parturients: anesthetic considerations. (21519980)
2011
29
Presumed idiopathic intracranial hypertension: A case report and literature review. (21970247)
2011
30
Intracranial hypertension and ciprofloxacin. (21483143)
2011
31
Idiopathic intracranial hypertension: lumboperitoneal shunts versus ventriculoperitoneal shunts--case series and literature review. (21323404)
2011
32
Comments on: clinical profile of cerebral venous sinus thrombosis and role of imaging in its diagnosis in patients with presumed idiopathic intracranial hypertension. (21666336)
2011
33
Disease activity in idiopathic intracranial hypertension: a 3-month follow-up study. (20853113)
2011
34
Dynamics of intracranial venous flow patterns in patients with idiopathic intracranial hypertension. (22086254)
2011
35
Decompressive craniectomy: surgical control of traumatic intracranial hypertension may improve outcome. (21574279)
2010
36
Clinical profile of cerebral venous sinus thrombosis and the role of imaging in its diagnosis in patients with presumed idiopathic intracranial hypertension. (20195042)
2010
37
Utility of transcranial doppler in idiopathic intracranial hypertension. (20437935)
2010
38
Cerebrospinal fluid corticosteroid levels and cortisol metabolism in patients with idiopathic intracranial hypertension: a link between 11beta-HSD1 and intracranial pressure regulation? (20826586)
2010
39
Rarebit perimetry in the evaluation of visual field defects in idiopathic intracranial hypertension. (20306442)
2010
40
Seventh nerve palsy as a false localizing sign in benign intracranial hypertension. (20829324)
2010
41
Intracranial hypertension secondary to sigmoid sinus compression by group A streptococcal epidural abscess. (19646300)
2010
42
Weight and visual field deficits in women with idiopathic intracranial hypertension. (20849287)
2010
43
Choroidal infarction in fulminant idiopathic intracranial hypertension. (20404747)
2010
44
Idiopathic intracranial hypertension without papilloedema in headache sufferers. (19170702)
2009
45
Lumbar subcutaneous shunt: a novel technique for therapeutic decision making in normal pressure hydrocephalus (NPH) and benign intracranial hypertension (BIH). (19016120)
2008
46
Visual loss and idiopathic intracranial hypertension in children with Alagille syndrome. (16954958)
2006
47
Benign intracranial hypertension associated with hypervitaminosis A. (9503739)
1998
48
Gliomatosis cerebri or benign intracranial hypertension? (7644408)
1995
49
Benign intracranial hypertension associated with hypervitaminosis A. (5409596)
1970
50
Papilledema and asymptomatic intracranial hypertension in systemic lupus erythematosus. A fluorescein angiographic study of resolving papilledema. (5661884)
1968

Genetic Variations for Intracranial Hypertension

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Expression for genes affiliated with Intracranial Hypertension

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Intracranial Hypertension

Search GEO for disease gene expression data for Intracranial Hypertension.

Pathways for genes affiliated with Intracranial Hypertension

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Sources:
37NCBI BioSystems Database, 29KEGG, 53Reactome, 52R&D Systems, 51QIAGEN, 12EMD Millipore
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Pathways related to Intracranial Hypertension according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8TWIST1, SERPINE1, LEP
2
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9.8F5, SERPINE1, SERPINC1
3
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9.8F5, SERPINE1, SERPINC1
4
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9.7ALB, SERPINE1, F5
5
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9.6F5, LAMC2, SERPINE1, SERPINC1
6
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9.5IL1B, FOSB, TNF
7
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9.4TNF, CXCL10, IL1B, SERPINE1
89.4AQP4, IL1B, SSTR1, TNF
9
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9.4TNF, FOSB, RBP4, LEP
109.3TNF, IL1B, SERPINE1, ALB
119.3AQP4, LEP, IL1B, CXCL10, TNF
12
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9.3TNF, FOSB, IL1B, SERPINE1
13
Hide members
8.7CACNA1A, TNF, FOSB, CXCL10, IL1B, LAMC2

Compounds for genes affiliated with Intracranial Hypertension

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Sources:
44Novoseek, 2BitterDB, 59Tocris Bioscience, 11DrugBank, 28IUPHAR, 24HMDB, 49PharmGKB
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Compounds related to Intracranial Hypertension according to GeneCards/GeneDecks:

(show top 50)    (show all 125)
idCompoundScoreTop Affiliating Genes
1hydrocortisone44 2 59 1113.7HSD11B1
2heparin44 28 11 2413.6APOH
3estrogen4410.5HSD11B1, APOH
4dextran sulfate4410.5F5, APOH
5warfarin44 49 11 2413.4SERPINC1, APOH
6dexamethasone44 49 28 1113.4HSD11B1, AQP4, RBP4
7gabexate mesilate4410.4F5, SERPINC1
8rosiglitazone44 49 28 11 2414.3LEP, RBP4, HSD11B1
9alpha tocopherol4410.3APOH, RBP4
10uric acid44 2411.3APOH, F5, SERPINE1
11tacrolimus44 49 1112.3CXCL10, ALB
12endotoxin4410.3SERPINE1, APOH, F5
13glucose4410.3TSC1, APOH, RBP4, ATP1A2
14ancrod4410.2SERPINC1, SERPINE1, F5
15prednisolone44 28 1112.1HSD11B1, APOH
16hextend4410.1ALB, SERPINC1
17fatty acid4410.1HSD11B1, RBP4, ATP1A2, APOH
18kininogen4410.1SERPINC1, SERPINE1, F5, APOH
19taurine chloramine4410.0IL1B, F5, TNF
20sodium44 2411.0AQP4, CACNA1A, ATP1A2, HSD11B1
21tibolone4410.0LEP, SERPINE1, SERPINC1, F5
22glutamate4410.0CACNA1A, AQP4, APOH, ATP1A2
23gold449.9CXCL10, RBP4, APOH, LAMC2, AQP4
248-isoprostane449.9SERPINE1, TNF, LEP, APOH
25aminoguanidine44 28 1111.9IL1B, ALB, LEP
26infliximab44 49 1111.9CXCL10, APOH, TNF, IL1B
27etanercept44 49 1111.9LEP, IL1B, TNF, APOH
28hydrochlorothiazide44 49 28 11 2413.8SERPINE1, ALB, SLC12A3
29ivig449.8TNF, APOH, IL1B, ALB
30pioglitazone44 49 28 1112.7LEP, RBP4, TNF, SERPINE1, HSD11B1
31folate449.7APOH, RBP4, F5, SERPINC1, ALB
32p002449.7RBP4, APOH, F5, LEP
33homocysteine44 2410.7ALB, APOH, SERPINE1, SERPINC1, F5
34aspirin44 49 28 2412.7IL1B, SERPINC1, SERPINE1, APOH, F5
35creatinine449.6ALB, LEP, CXCL10, F5, RBP4, APOH
36polymyxin b449.6IL1B, TNF, SERPINE1
37ascorbic acid44 2410.5SERPINC1, RBP4, LEP, ALB, F5
38progesterone44 59 28 11 2413.4LEP, F5, SERPINE1, RBP4, HSD11B1, APOH
39troglitazone44 28 59 1112.4SERPINE1, LEP, IL1B, TNF
40methotrexate44 49 1111.3SERPINE1, TNF, APOH, ALB, IL1B, LEP
41prostacyclin449.2TNF, LEP, SERPINE1, SERPINC1, F5, APOH
42testosterone44 59 11 2412.2F5, LEP, SERPINC1, RBP4, HSD11B1, SERPINE1
43alanine449.2HSD11B1, RBP4, F5, SLC12A3, CXCL10, TSC1
44fibrinogen449.2LEP, APOH, ALB, SERPINC1, F5, SERPINE1
45cholesterol44 28 11 2412.1HSD11B1, CXCL10, F5, ALB, SERPINE1, APOH
46histamine44 28 2410.9TNF, CXCL10, IL1B, AQP4, ALB
47vegf448.9IL1B, TSC1, SERPINC1, SERPINE1, LEP, TNF
48lipid448.9TNF, APOH, HSD11B1, CXCL10, RBP4, LEP
49serine448.8TNF, CACNA1A, SSTR1, LEP, RBP4, SLC12A3
50calcium44 49 11 2411.2SSTR1, CXCL10, SLC12A3, ALB, ATP1A2, F5

GO Terms for genes affiliated with Intracranial Hypertension

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16Gene Ontology
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Cellular components related to Intracranial Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein complexGO:0432349.7AQP4, ALB, TSC1, RBP4
2platelet alpha granule lumenGO:0310939.4F5, SERPINE1, ALB
3extracellular spaceGO:0056158.1ALB, TNF, APOH, RBP4, F5, CXCL10
4extracellular regionGO:0055767.9TNF, RBP4, F5, CXCL10, IL1B, LEP

Biological processes related to Intracranial Hypertension according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of monocyte chemotactic protein-1 productionGO:07163910.3IL1B, TWIST1
2positive regulation of calcidiol 1-monooxygenase activityGO:06055910.2TNF, IL1B
3sequestering of triglycerideGO:03073010.1TNF, IL1B
4positive regulation of heterotypic cell-cell adhesionGO:03411610.1IL1B, TNF
5negative regulation of fibrinolysisGO:05191810.1SERPINE1, APOH
6response to insulin stimulusGO:03286810.1RBP4, LEP, TSC1
7positive regulation of fever generationGO:03162210.1IL1B, TNF
8positive regulation of chemokine biosynthetic processGO:04508010.0IL1B, TNF
9regulation of I-kappaB kinase/NF-kappaB cascadeGO:04312210.0IL1B, TNF
10leukocyte tethering or rollingGO:0509019.9LEP, TNF
11response to nutrientGO:0075849.8SSTR1, SERPINC1, ALB
12positive regulation of blood coagulationGO:0301949.8SERPINE1, APOH
13platelet degranulationGO:0025769.7F5, SERPINE1, ALB
14positive regulation of angiogenesisGO:0457669.7TWIST1, SERPINE1, IL1B
15regulation of insulin secretionGO:0507969.7LEP, IL1B, TNF, CACNA1A

Molecular functions related to Intracranial Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:0020209.7SERPINC1, SERPINE1, TNF

Products for genes affiliated with Intracranial Hypertension

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  • Antibodies
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Sources for Intracranial Hypertension

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet