MCID: INT075
MIFTS: 51

Intracranial Hypertension malady

Neuronal diseases category

Summaries for Intracranial Hypertension

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Sources:
45NINDS, 66Wikipedia, 34MalaCards
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NINDS:45 Pseudotumor cerebri literally means "false brain tumor." It is likely due to high pressure within the skull caused by the buildup or poor absorption of cerebrospinal fluid (CSF). The disorder is most common in women between the ages of 20 and 50. Symptoms of pseudotumor cerebri, which include headache, nausea, vomiting, and pulsating sounds within the head, closely mimic symptoms of large brain tumors.

MalaCards: Intracranial Hypertension, also known as raised intracranial pressure, is related to hydrocephalus and malaria. An important gene associated with Intracranial Hypertension is TSC1 (tuberous sclerosis 1). The drugs thiopental and urea and the compounds phorbol and mercury have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and ovary, and related mouse phenotypes are skeleton and muscle.

Wikipedia:66 Intracranial pressure (ICP) is the pressure inside the skull and thus in the brain tissue and... more...

Aliases & Classifications for Intracranial Hypertension

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Sources:
9Disease Ontology, 45NINDS, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 41NCIt, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

intracranial hypertension 9 45 11 46 63
raised intracranial pressure 9


External Ids:

Disease Ontology9 DOID:9428
NCIt41 C84791
MeSH36 D019586

Related Diseases for Intracranial Hypertension

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Intracranial Hypertension:



Diseases related to intracranial hypertension

Symptoms for Intracranial Hypertension

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Drugs & Therapeutics for Intracranial Hypertension

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Intracranial Hypertension

Drug clinical trials:

Search ClinicalTrials for Intracranial Hypertension

Search NIH Clinical Center for Intracranial Hypertension

Search CenterWatch for Intracranial Hypertension

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Intracranial Hypertension

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Anatomical Context for Intracranial Hypertension

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Sources:
34MalaCards
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MalaCards organs/tissues related to Intracranial Hypertension:

34
Brain, Liver, Ovary, Eye, Heart, Spinal cord, Testes, Kidney, Thyroid, Prostate

Animal Models for Intracranial Hypertension or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Intracranial Hypertension:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.7NPPC, TWIST1, TSC1
2MP:00053698.6TSC1, TWIST1, RBP4
3MP:00053798.5NPPC, RBP4, TSC1, AQP4
4MP:00053768.4NPPC, RBP4, TSC1, AQP4
5MP:00053858.2AQP4, TSC1, TWIST1, RBP4
6MP:00036318.2NPPC, TWIST1, TSC1, AQP4
7MP:00053788.1AQP4, TSC1, TWIST1, NPPC
8MP:00107687.8NPPC, TWIST1, TSC1, AQP4

Publications for Intracranial Hypertension

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Sources:
53PubMed
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Articles related to Intracranial Hypertension:

(show top 50)    (show all 612)
idTitleAuthorsYear
1
Obesity and the role of nonsurgical and surgical weight reduction in idiopathic intracranial hypertension. (24296369)
2014
2
Olfactory dysfunction in patients with idiopathic intracranial hypertension. (24419980)
2014
3
Intracranial hypertension in a patient preparing for gestational surrogacy with leuprolide acetate and estrogen. (23612241)
2013
4
Increased levels of interleukins 2 and 17 in the cerebrospinal fluid of patients with idiopathic intracranial hypertension. (24179731)
2013
5
Venous hypertension as the cause of intracranial hypertension in patients with transverse sinus dural arteriovenous fistula. (22495458)
2013
6
Conjunctival oedema as a potential objective sign of intracranial hypertension: a short illustrated review and three case reports. (23793919)
2013
7
Effect of mannitol on cerebrovascular pressure reactivity in patients with intracranial hypertension. (24090636)
2013
8
Can ocular ultrasound predict intracranial hypertension? A pilot diagnostic accuracy evaluation in a UK emergency department. (22327166)
2013
9
MRI findings of elevated intracranial pressure in cerebral venous thrombosis versus idiopathic intracranial hypertension with transverse sinus stenosis. (24019557)
2013
10
Design and benchmark testing of a bicorporal pump for the treatment of normal-pressure hydrocephalus and idiopathic intracranial hypertension. (23215632)
2013
11
Lumboperitoneal shunt for idiopathic intracranial hypertension: patients' selection and outcome. (21956361)
2012
12
Intracranial pressure/cerebral perfusion pressure-targeted management of life-threatening intracranial hypertension complicating diabetic ketoacidosis-associated cerebral edema: a case report. (22766587)
2012
13
Update on the pathophysiology and management of idiopathic intracranial hypertension. (22423118)
2012
14
Intracranial hypertension secondary to psychogenic polydipsia. (22787354)
2012
15
Letters to the editor: Stenting and idiopathic intracranial hypertension. (23020766)
2012
16
Acute surgical management in idiopathic intracranial hypertension. (23239783)
2012
17
Blood flow velocities during experimental intracranial hypertension in pigs. (22889577)
2012
18
Intracranial hypertension with delayed puberty: a rare presentation of juvenile onset systemic lupus erythematosus. (22252192)
2012
19
Response to intracranial hypertension treatment as a predictor of death in patients with severe traumatic brain injury. (21214327)
2011
20
Intracranial hypertension in two cases of craniometaphyseal dysplasia: differing surgical options. (21806345)
2011
21
MR imaging findings in patients with secondary intracranial hypertension. (21511864)
2011
22
Idiopathic intracranial hypertension. (21788420)
2011
23
Transverse sinus stenting for idiopathic intracranial hypertension: a review of 52 patients and of model predictions. (21799038)
2011
24
Idiopathic intracranial hypertension and facial palsy: case report and review of the literature. (20921567)
2010
25
Successful management of refractory intracranial hypertension from acute hyperammonemic encephalopathy in a woman with ornithine transcarbamylase deficiency. (20422467)
2010
26
Cushing's disease and idiopathic intracranial hypertension: case report and review of underlying pathophysiological mechanisms. (20739379)
2010
27
Hypertonic saline more efficacious than mannitol in lethal intracranial hypertension model. (19309542)
2010
28
Absence of aquaporin-4 antibodies in patients with idiopathic intracranial hypertension. (20232212)
2010
29
Intracranial hypertension: A rare presentation of lupus nephritis. (21559160)
2010
30
Decompressive craniectomy: surgical control of traumatic intracranial hypertension may improve outcome. (21574279)
2010
31
Clinical profile of cerebral venous sinus thrombosis and the role of imaging in its diagnosis in patients with presumed idiopathic intracranial hypertension. (20195042)
2010
32
Prolonged hypothermia as a bridge to recovery for cerebral edema and intracranial hypertension associated with fulminant hepatic failure. (19728177)
2009
33
Relevance of intracranial hypertension for cerebral metabolism in aneurysmal subarachnoid hemorrhage. Clinical article. (19284237)
2009
34
Elevated cerebrospinal fluid (CSF) leptin in idiopathic intracranial hypertension (IIH): evidence for hypothalamic leptin resistance? (18771566)
2009
35
Effectiveness of ketamine in decreasing intracranial pressure in children with intracranial hypertension. (19569909)
2009
36
Idiopathic intracranial hypertension in men and the relationship to sleep apnea. (18923134)
2009
37
Follow-up of mild papilledema in idiopathic intracranial hypertension with optical coherence tomography. (19011007)
2009
38
From pseudotumour cerebri to idiopathic intracranial hypertension. (19923117)
2009
39
Therapeutic hypothermia in patients with aneurysmal subarachnoid hemorrhage, refractory intracranial hypertension, or cerebral vasospasm. (19050656)
2009
40
Challenging the gold standard: should mannitol remain our first-line defense against intracranial hypertension? (19170304)
2008
41
Spinal cord astrocytoma presenting as "idiopathic" intracranial hypertension. (16298472)
2006
42
Rebound intracranial hypertension after treatment of spontaneous intracranial hypotension. (16834710)
2006
43
Obstructive hydrocephalus and intracranial hypertension caused by a giant macroprolactinoma. Prompt response to medical treatment. (16205966)
2006
44
Visual loss and idiopathic intracranial hypertension in children with Alagille syndrome. (16954958)
2006
45
Idiopathic intracranial hypertension presenting as hemiplegic migraine. (12222727)
2002
46
Images in clinical medicine. Papilledema associated with intracranial hypertension. (11346809)
2001
47
Coexistence of migraine and idiopathic intracranial hypertension without papilledema. (8628457)
1996
48
Gliomatosis cerebri or benign intracranial hypertension? (7644408)
1995
49
Intracranial hypertension and adult respiratory distress syndrome: usefulness of tracheal gas insufflation. (7473982)
1995
50
Benign intracranial hypertension without papilledema: case report. (503301)
1979

Variations for Intracranial Hypertension

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Expression for genes affiliated with Intracranial Hypertension

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Intracranial Hypertension

Search GEO for disease gene expression data for Intracranial Hypertension.

Pathways for genes affiliated with Intracranial Hypertension

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Compounds for genes affiliated with Intracranial Hypertension

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Sources:
46Novoseek, 25HMDB, 12DrugBank, 52PharmGKB, 30IUPHAR
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Compounds related to Intracranial Hypertension according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1phorbol469.7NPPC, RBP4
2mercury469.6RBP4, AQP4
3urea46 25 1211.5AQP4, RBP4
4gold469.5RBP4, AQP4
5sucrose46 25 1211.3RBP4, AQP4
6chloride469.2AQP4, NPPC
7dexamethasone46 52 30 1212.0NPPC, RBP4, AQP4
8glucose469.0NPPC, RBP4, TSC1
9histamine46 30 2511.0NPPC, AQP4
10serine469.0NPPC, RBP4, TSC1
11retinoic acid46 2510.0NPPC, RBP4, AQP4
12cysteine468.9AQP4, RBP4, NPPC

GO Terms for genes affiliated with Intracranial Hypertension

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Sources:
17Gene Ontology
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Cellular components related to Intracranial Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein complexGO:0432348.9RBP4, TSC1, AQP4

Biological processes related to Intracranial Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to insulinGO:0328689.5RBP4, TSC1
2response to ethanolGO:0454719.4NPPC, RBP4
3neural tube closureGO:0018439.1TWIST1, TSC1
4ossificationGO:0015038.8NPPC, TWIST1

Products for genes affiliated with Intracranial Hypertension

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Intracranial Hypertension

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet