MCID: INT075
MIFTS: 59

Intracranial Hypertension malady

Summaries for Intracranial Hypertension

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43NINDS, 63Wikipedia, 32MalaCards
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NINDS:43 Pseudotumor cerebri literally means "false brain tumor." It is likely due to high pressure within the skull caused by the buildup or poor absorption of cerebrospinal fluid (CSF). The disorder is most common in women between the ages of 20 and 50. Symptoms of pseudotumor cerebri, which include headache, nausea, vomiting, and pulsating sounds within the head, closely mimic symptoms of large brain tumors.

MalaCards: Intracranial Hypertension, also known as raised intracranial pressure, is related to hypertension and pseudotumor cerebri. An important gene associated with Intracranial Hypertension is TSC1 (tuberous sclerosis 1), and among its related pathways are Adipogenesis and Complement and coagulation cascades. The drugs carbamide peroxide and urea and the compounds hydrocortisone and heparin have been mentioned in the context of this disorder. Affiliated tissues include brain, ovary and liver, and related mouse phenotypes are renal/urinary system and integument.

Wikipedia:63 Intracranial pressure (ICP) is the pressure inside the skull and thus in the brain tissue and... more...

Aliases & Classifications for Intracranial Hypertension

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8Disease Ontology, 43NINDS, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

intracranial hypertension 8 43 10 44 60
raised intracranial pressure 8


External Ids:

Disease Ontology8 DOID:9428
NCIt39 C84791
MeSH34 D019586

Related Diseases for Intracranial Hypertension

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Intracranial Hypertension via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 316)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension32.0ALB, SERPINE1, SLC12A3, LEP, F5, HSD11B1
2pseudotumor cerebri31.1SSTR1, RBP4
3obesity30.8HSD11B1, TNF, RBP4, LEP, SERPINE1
4intracranial thrombosis30.8APOH, F5, SERPINC1
5lupus erythematosus30.6APOH, F5, SERPINC1
6meningitis30.6CXCL10, IL1B, ALB
7systemic lupus erythematosus30.5CXCL10, RBP4, APOH, TNF
8migraine30.4CACNA1A, APOH, ATP1A2
9sagittal sinus thrombosis30.3F5, SERPINC1
10neuropathy30.3ALB, CACNA1A
11brain edema30.3AQP4, ALB
12hepatitis30.3RBP4, CXCL10, ALB
13meningioma30.2TSC1
14polycystic ovary syndrome30.2SERPINE1, LEP, RBP4, HSD11B1
15malaria30.2TNF, RBP4, ALB
16cadasil30.2APOH, F5, SERPINE1, SERPINC1, AQP4
17polyneuropathy30.1RBP4
18nephrotic syndrome30.1ALB, SERPINC1, RBP4
19encephalitis30.1AQP4, IL1B, CXCL10
20leukemia30.1TNF, RBP4, IL1B
21peritonitis30.1TNF, IL1B, ALB
22sjogren's syndrome29.9APOH
23hypothyroidism29.9LEP
24hyperthyroidism29.9LEP
25glaucoma29.9AQP4, HSD11B1
26hepatic encephalopathy29.9ALB, AQP4
27antiphospholipid syndrome29.9SERPINC1, F5, APOH
28hyperandrogenism29.9LEP
29myeloma29.9ALB, IL1B
30adenoma29.9TSC1, LAMC2, SSTR1, HSD11B1
31prostate cancer29.9SSTR1, CXCL10, LAMC2, TWIST1
32protein c deficiency29.9APOH, F5, SERPINE1, SERPINC1
33thrombophilia29.9APOH, F5, SERPINE1, SERPINC1
34adult respiratory distress syndrome29.9TNF, F5, IL1B
35astrocytoma29.9AQP4, TSC1, IL1B, CXCL10
36vascular disease29.9APOH, F5, SERPINE1, SERPINC1
37essential hypertension29.9LEP, SLC12A3, SERPINE1, ALB
38papilledema10.8
39cerebritis10.7
40intracranial sinus thrombosis10.5
41hydrocephalus10.4
42choroiditis10.4
43intracranial hypotension10.3
44adrenoleukodystrophy10.3
45hypervitaminosis a10.3
46synostosis10.3
47arachnoiditis10.2
48empty sella syndrome10.2
49ocular hypertension10.2
50malignant hypertension10.2

Graphical network of the top 20 diseases related to Intracranial Hypertension:



Diseases related to intracranial hypertension

Clinical Features for Intracranial Hypertension

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Drugs & Therapeutics for Intracranial Hypertension

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Intracranial Hypertension

Drug clinical trials:

Search ClinicalTrials for Intracranial Hypertension

Search NIH Clinical Center for Intracranial Hypertension

Search CenterWatch for Intracranial Hypertension

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Intracranial Hypertension

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Anatomical Context for Intracranial Hypertension

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32MalaCards
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MalaCards organs/tissues related to Intracranial Hypertension:

32
Brain, Ovary, Liver, Heart, Testes, Spinal cord, Eye, Thyroid, Kidney, Prostate

Animal Models for Intracranial Hypertension or affiliated genes

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36MGI
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Publications for Intracranial Hypertension

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50PubMed
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Articles related to Intracranial Hypertension:

(show top 50)    (show all 638)
idTitleAuthorsYear
1
Rebound Intracranial Hypertension: A Complication of Epidural Blood Patching for Intracranial Hypotension. (24407273)
2014
2
Intracranial hypertension in a patient preparing for gestational surrogacy with leuprolide acetate and estrogen. (23612241)
2013
3
MRI findings of elevated intracranial pressure in cerebral venous thrombosis versus idiopathic intracranial hypertension with transverse sinus stenosis. (24019557)
2013
4
Slit ventricle syndrome: a case report of intermittent intracranial hypertension. (22805245)
2013
5
Albumin resuscitation for traumatic brain injury: is intracranial hypertension the cause of increased mortality? (23194432)
2013
6
Association of MRI findings and visual outcome in idiopathic intracranial hypertension. (23883223)
2013
7
A case of Bardet-Biedl syndrome complicated with intracranial hypertension in a Japanese child. (24290075)
2013
8
Bibrachial amyotrophy and ventral spinal cyst associated with myelomalacia and intracranial hypertension. (24100111)
2013
9
Intracranial hypertension due to meningioma of the unique transverse sinus. (23859244)
2013
10
Characteristics and sequelae of intracranial hypertension after intracerebral hemorrhage. (22833445)
2012
11
The entire dural sinus tree is compressed in patients with idiopathic intracranial hypertension: a longitudinal, volumetric magnetic resonance imaging study. (21340576)
2012
12
Comparison of accuracy of optic nerve ultrasound for the detection of intracranial hypertension in the setting of acutely fluctuating vs stable intracranial pressure: post-hoc analysis of data from a prospective, blinded single center study. (22578001)
2012
13
Accuracy of brain imaging in the diagnosis of idiopathic intracranial hypertension. (22309765)
2012
14
The surgical management of intracranial hypertension following traumatic brain injury. (22577927)
2012
15
Intracranial hypertension prediction using extremely randomized decision trees. (22401795)
2012
16
Association of benign intracranial hypertension and spontaneous encephalocele with cerebrospinal fluid leak. (23150096)
2012
17
Transverse sinus stenting for idiopathic intracranial hypertension: a review of 52 patients and of model predictions. (21799038)
2011
18
Electromagnetic stereotactic ventriculoperitoneal csf shunting for idiopathic intracranial hypertension: a successful step forward? (21492681)
2011
19
A case of Gitelman syndrome associated with idiopathic intracranial hypertension. (21757836)
2011
20
Early detection of severe intracranial hypertension by transcranial Doppler before the occurrence of clinical and radiologic manifestations. (21150461)
2011
21
Migraine misdiagnosed as idiopathic intracranial hypertension. (21883196)
2011
22
Transcranial Doppler can predict intracranial hypertension in children with severe traumatic brain injuries. (21207041)
2011
23
Inflammatory and haemostatic markers in idiopathic intracranial hypertension. (21883536)
2011
24
Intracranial hypertension as the first manifestation of primary Sjogren's syndrome. (21216872)
2011
25
Prognostic significance of intracranial pressure monitoring and intracranial hypertension in severe brain trauma patients. (22097111)
2011
26
An update on idiopathic intracranial hypertension. (20944524)
2010
27
Intracranial hypertension, headache and obesity: insights from magnetic resonance venography. (20974605)
2010
28
Cytokines in idiopathic intracranial hypertension CSF. (20039956)
2010
29
Teaching NeuroImages: idiopathic intracranial hypertension: MRI features. (20157154)
2010
30
Idiopathic intracranial hypertension presenting as CSF rhinorrhea. (20436754)
2010
31
Relevance of intracranial hypertension for cerebral metabolism in aneurysmal subarachnoid hemorrhage. Clinical article. (19284237)
2009
32
Idiopathic intracranial hypertension in men and the relationship to sleep apnea. (18923134)
2009
33
Treating intracranial hypertension: time to abandon mannitol? (19485871)
2009
34
Double adverse drug reaction: Recombinant human growth hormone and idiopathic intracranial hypertension - acetazolamide and metabolic acidosis: a case report. (19829821)
2009
35
Idiopathic intracranial hypertension: a comparison between French and North-American white patients. (19157473)
2009
36
Post-varicella idiopathic intracranial hypertension in a child. (19426383)
2009
37
Intracranial hypertension. (19115175)
2008
38
Cardiac uncoupling and heart rate variability are associated with intracranial hypertension and mortality: a study of 145 trauma patients with continuous monitoring. (18784576)
2008
39
Intracranial pressure in primary open angle glaucoma, normal tension glaucoma, and ocular hypertension: a case-control study. (18719086)
2008
40
Shunt failure in idiopathic intracranial hypertension presenting with spontaneous cerebrospinal fluid leak. (16678427)
2006
41
Brain edema and intracranial hypertension in fulminant hepatic failure: pathophysiology and management. (17167826)
2006
42
Idiopathic intracranial hypertension in cystinosis. (15520772)
2004
43
Long-term evolution of papilledema in idiopathic intracranial hypertension: observations concerning two cases. (12131949)
2002
44
A 14-year-old Nigerian female with idiopathic intracranial hypertension (Pseudotumor cerebri or benign intracranial hypertension). (12789098)
2002
45
Asymmetric papilledema in idiopathic intracranial hypertension: prospective interocular comparison of sensory visual function. (9430554)
1998
46
The detection and management of intracranial hypertension after initial suture release and decompression for craniofacial dysostosis syndromes. (7596500)
1995
47
MR imaging of cerebrospinal fluid dynamics in health and disease. On the vascular pathogenesis of communicating hydrocephalus and benign intracranial hypertension. (8192953)
1994
48
On-line monitoring of global cerebral hypoxia in acute brain injury. Relationship to intracranial hypertension. (8331405)
1993
49
Idiopathic intracranial hypertension without papilledema. (2012512)
1991
50
Idiopathic intracranial hypertension (pseudotumor cerebri): MR imaging. (2909098)
1989

Genetic Variations for Intracranial Hypertension

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Expression for genes affiliated with Intracranial Hypertension

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Intracranial Hypertension

Search GEO for disease gene expression data for Intracranial Hypertension.

Pathways for genes affiliated with Intracranial Hypertension

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Sources:
37NCBI BioSystems Database, 29KEGG, 53Reactome, 52R&D Systems, 51QIAGEN, 12EMD Millipore
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Pathways related to Intracranial Hypertension according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8SERPINE1, LEP, TWIST1
2
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9.8SERPINC1, SERPINE1, F5
3
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9.8SERPINE1, SERPINC1, F5
4
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9.7ALB, SERPINE1, F5
5
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9.6LAMC2, SERPINC1, F5, SERPINE1
6
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9.5TNF, FOSB, IL1B
7
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9.4TNF, IL1B, SERPINE1, CXCL10
89.4AQP4, IL1B, TNF, SSTR1
9
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9.4TNF, LEP, FOSB, RBP4
109.3ALB, IL1B, SERPINE1, TNF
119.3CXCL10, IL1B, LEP, AQP4, TNF
12
Hide members
9.3IL1B, SERPINE1, FOSB, TNF
13
Hide members
8.7IL1B, FOSB, CACNA1A, CXCL10, LAMC2, TSC1

Compounds for genes affiliated with Intracranial Hypertension

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Sources:
44Novoseek, 2BitterDB, 59Tocris Bioscience, 11DrugBank, 28IUPHAR, 24HMDB, 49PharmGKB
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Compounds related to Intracranial Hypertension according to GeneCards/GeneDecks:

(show top 50)    (show all 125)
idCompoundScoreTop Affiliating Genes
1hydrocortisone44 2 59 1113.7HSD11B1
2heparin44 28 11 2413.6APOH
3estrogen4410.5HSD11B1, APOH
4dextran sulfate4410.5F5, APOH
5warfarin44 49 11 2413.4SERPINC1, APOH
6dexamethasone44 49 28 1113.4HSD11B1, AQP4, RBP4
7gabexate mesilate4410.4F5, SERPINC1
8rosiglitazone44 49 28 11 2414.3LEP, RBP4, HSD11B1
9alpha tocopherol4410.3APOH, RBP4
10uric acid44 2411.3APOH, F5, SERPINE1
11tacrolimus44 49 1112.3CXCL10, ALB
12endotoxin4410.3SERPINE1, APOH, F5
13glucose4410.3TSC1, APOH, RBP4, ATP1A2
14ancrod4410.2SERPINC1, SERPINE1, F5
15prednisolone44 28 1112.1HSD11B1, APOH
16hextend4410.1ALB, SERPINC1
17fatty acid4410.1HSD11B1, RBP4, ATP1A2, APOH
18kininogen4410.1SERPINC1, SERPINE1, F5, APOH
19taurine chloramine4410.0IL1B, F5, TNF
20sodium44 2411.0AQP4, CACNA1A, ATP1A2, HSD11B1
21tibolone4410.0LEP, SERPINE1, SERPINC1, F5
22glutamate4410.0CACNA1A, AQP4, APOH, ATP1A2
23gold449.9CXCL10, RBP4, APOH, LAMC2, AQP4
248-isoprostane449.9SERPINE1, TNF, LEP, APOH
25aminoguanidine44 28 1111.9IL1B, ALB, LEP
26infliximab44 49 1111.9CXCL10, APOH, TNF, IL1B
27etanercept44 49 1111.9LEP, IL1B, TNF, APOH
28hydrochlorothiazide44 49 28 11 2413.8SERPINE1, ALB, SLC12A3
29ivig449.8TNF, APOH, IL1B, ALB
30pioglitazone44 49 28 1112.7LEP, RBP4, TNF, SERPINE1, HSD11B1
31folate449.7APOH, RBP4, F5, SERPINC1, ALB
32p002449.7RBP4, APOH, F5, LEP
33homocysteine44 2410.7ALB, APOH, SERPINE1, SERPINC1, F5
34aspirin44 49 28 2412.7IL1B, SERPINC1, SERPINE1, APOH, F5
35creatinine449.6ALB, LEP, CXCL10, F5, RBP4, APOH
36polymyxin b449.6IL1B, TNF, SERPINE1
37ascorbic acid44 2410.5SERPINC1, RBP4, LEP, ALB, F5
38progesterone44 59 28 11 2413.4LEP, F5, SERPINE1, RBP4, HSD11B1, APOH
39troglitazone44 28 59 1112.4SERPINE1, LEP, IL1B, TNF
40methotrexate44 49 1111.3SERPINE1, TNF, APOH, ALB, IL1B, LEP
41prostacyclin449.2TNF, LEP, SERPINE1, SERPINC1, F5, APOH
42testosterone44 59 11 2412.2F5, LEP, SERPINC1, RBP4, HSD11B1, SERPINE1
43alanine449.2HSD11B1, RBP4, F5, SLC12A3, CXCL10, TSC1
44fibrinogen449.2LEP, APOH, ALB, SERPINC1, F5, SERPINE1
45cholesterol44 28 11 2412.1HSD11B1, CXCL10, F5, ALB, SERPINE1, APOH
46histamine44 28 2410.9TNF, CXCL10, IL1B, AQP4, ALB
47vegf448.9IL1B, TSC1, SERPINC1, SERPINE1, LEP, TNF
48lipid448.9TNF, APOH, HSD11B1, CXCL10, RBP4, LEP
49serine448.8TNF, CACNA1A, SSTR1, LEP, RBP4, SLC12A3
50calcium44 49 11 2411.2SSTR1, CXCL10, SLC12A3, ALB, ATP1A2, F5

GO Terms for genes affiliated with Intracranial Hypertension

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16Gene Ontology
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Cellular components related to Intracranial Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein complexGO:0432349.7AQP4, ALB, TSC1, RBP4
2platelet alpha granule lumenGO:0310939.4F5, SERPINE1, ALB
3extracellular spaceGO:0056158.1LEP, SERPINC1, SERPINE1, IL1B, CXCL10, F5
4extracellular regionGO:0055767.9ALB, TNF, SERPINC1, SERPINE1, LAMC2, LEP

Biological processes related to Intracranial Hypertension according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of monocyte chemotactic protein-1 productionGO:07163910.3IL1B, TWIST1
2positive regulation of calcidiol 1-monooxygenase activityGO:06055910.2TNF, IL1B
3sequestering of triglycerideGO:03073010.1TNF, IL1B
4positive regulation of heterotypic cell-cell adhesionGO:03411610.1IL1B, TNF
5negative regulation of fibrinolysisGO:05191810.1SERPINE1, APOH
6response to insulin stimulusGO:03286810.1RBP4, LEP, TSC1
7positive regulation of fever generationGO:03162210.1IL1B, TNF
8positive regulation of chemokine biosynthetic processGO:04508010.0IL1B, TNF
9regulation of I-kappaB kinase/NF-kappaB cascadeGO:04312210.0IL1B, TNF
10leukocyte tethering or rollingGO:0509019.9LEP, TNF
11response to nutrientGO:0075849.8SSTR1, SERPINC1, ALB
12positive regulation of blood coagulationGO:0301949.8SERPINE1, APOH
13platelet degranulationGO:0025769.7F5, SERPINE1, ALB
14positive regulation of angiogenesisGO:0457669.7TWIST1, SERPINE1, IL1B
15regulation of insulin secretionGO:0507969.7LEP, IL1B, TNF, CACNA1A

Molecular functions related to Intracranial Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:0020209.7SERPINC1, SERPINE1, TNF

Products for genes affiliated with Intracranial Hypertension

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Sources for Intracranial Hypertension

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet