Aliases & Classifications for Intracranial Hypertension

MalaCards integrated aliases for Intracranial Hypertension:

Name: Intracranial Hypertension 12 50 51 41 14 69
Raised Intracranial Pressure 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9428
MeSH 41 D019586
NCIt 46 C84791
UMLS 69 C0151740

Summaries for Intracranial Hypertension

NINDS : 50 Pseudotumor cerebri literally means "false brain tumor." It is likely due to high pressure within the skull caused by the buildup or poor absorption of cerebrospinal fluid (CSF). The disorder is most common in women between the ages of 20 and 50. Symptoms of pseudotumor cerebri, which include headache, nausea, vomiting, and pulsating sounds within the head, closely mimic symptoms of large brain tumors.

MalaCards based summary : Intracranial Hypertension, also known as raised intracranial pressure, is related to intracranial hypertension, idiopathic and papilledema, and has symptoms including bulging fontanelle An important gene associated with Intracranial Hypertension is AQP4 (Aquaporin 4), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Mannitol and Cisatracurium have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and bone, and related phenotypes are homeostasis/metabolism and cardiovascular system

Related Diseases for Intracranial Hypertension

Diseases related to Intracranial Hypertension via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 360)
# Related Disease Score Top Affiliating Genes
1 intracranial hypertension, idiopathic 34.1 AQP1 AQP4 SSTR1
2 papilledema 31.1 APOH F2
3 brain edema 30.1 AQP1 AQP4 IL1B
4 sagittal sinus thrombosis 30.0 F2 F3 F5 SERPINC1
5 transverse myelitis 29.7 APOH AQP4 TNF
6 myelitis 29.7 APOH AQP4 TNF
7 migraine with or without aura 1 29.7 APOH MTHFR TNF
8 adult respiratory distress syndrome 29.6 F2 SERPINE1 TNF
9 demyelinating disease 29.5 AQP4 IL1B TNF
10 systemic lupus erythematosus 29.4 APOH F2 F3 IL1B TNF
11 peritonitis 29.4 AQP1 F2 IL1B TNF
12 thrombosis 29.4 APOH F2 F3 F5 MTHFR SERPINC1
13 protein c deficiency 29.3 F2 F5 MTHFR SERPINC1
14 pulmonary edema 29.3 F2 IL1B SERPINC1 TNF
15 thrombophilia due to thrombin defect 29.1 APOH F2 F3 F5 MTHFR SERPINC1
16 antiphospholipid syndrome 28.8 APOH F2 F3 F5 MTHFR SERPINC1
17 thrombophilia 27.9 APOH F2 F3 F5 FGA MTHFR
18 stroke, ischemic 27.6 APOH AQP4 F2 F3 F5 FGA
19 gapo syndrome 11.2
20 craniosynostosis 1 11.0
21 craniosynostosis 4 11.0
22 craniosynostosis 2 11.0
23 craniosynostosis 3 11.0
24 craniosynostosis 6 11.0
25 craniosynostosis 7 11.0
26 melanosis, neurocutaneous 10.9
27 may-thurner syndrome 10.6 APOH F5
28 acanthamoeba keratitis 10.5 APOH F5
29 paracetamol poisoning 10.5 F2 F5
30 cerebral falx meningioma 10.5 F2 F3
31 splenic infarction 10.5 APOH F2
32 acquired hemophilia a 10.5 F3 F5
33 fibrinolytic defect 10.5 SERPINC1 SERPINE1
34 acquired hemophilia 10.5 F3 F5
35 intracranial sinus thrombosis 10.4 F3 SERPINC1
36 von willebrand disease, type 1 10.4 F2 F3
37 heparin-induced thrombocytopenia 10.4 F3 SERPINC1
38 qualitative platelet defect 10.4 F2 F3
39 hemoglobin e disease 10.4 F2 F5
40 alpha-2-plasmin inhibitor deficiency 10.4 F2 SERPINC1
41 argentine hemorrhagic fever 10.4 SERPINC1 SERPINE1
42 marburg hemorrhagic fever 10.4 F2 TNF
43 inappropriate adh syndrome 10.4 AQP1 AQP4
44 polyposis, gastric 10.4 IL1B TNF
45 factor v deficiency 10.4 F2 F3 F5
46 mesenteric vascular occlusion 10.4 F2 MTHFR
47 cerebritis 10.3
48 intestinal impaction 10.3 F2 F3 SERPINC1
49 fournier gangrene 10.3 F2 F3 SERPINC1
50 leech infestation 10.3 F2 F3 SERPINC1

Graphical network of the top 20 diseases related to Intracranial Hypertension:



Diseases related to Intracranial Hypertension

Symptoms & Phenotypes for Intracranial Hypertension

UMLS symptoms related to Intracranial Hypertension:


bulging fontanelle

MGI Mouse Phenotypes related to Intracranial Hypertension:

43 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.31 HSD11B1 F3 APOH AQP1 F5 AQP4
2 cardiovascular system MP:0005385 10.27 HSD11B1 F3 AQP1 F5 AQP4 FGA
3 growth/size/body region MP:0005378 10.18 F2 F3 AQP1 F5 AQP4 HSD11B1
4 hematopoietic system MP:0005397 10.16 F3 AQP1 AQP4 FGA F2 SERPINC1
5 immune system MP:0005387 10.06 F2 F3 AQP4 FGA SERPINC1 HSD11B1
6 mortality/aging MP:0010768 10.03 APOH F3 AQP1 AQP4 F5 FGA
7 integument MP:0010771 10.02 F3 F5 FGA F2 HSD11B1 SERPINE1
8 nervous system MP:0003631 9.93 F3 AQP1 F5 AQP4 FGA F2
9 liver/biliary system MP:0005370 9.8 FGA F5 TNF SERPINC1 HSD11B1 SERPINE1
10 respiratory system MP:0005388 9.5 F2 F3 AQP1 AQP4 HSD11B1 SERPINE1
11 vision/eye MP:0005391 9.23 F3 AQP1 AQP4 FGA SERPINC1 SSTR1

Drugs & Therapeutics for Intracranial Hypertension

Drugs for Intracranial Hypertension (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 221)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mannitol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 69-65-8 6251 453
2 Cisatracurium Approved, Experimental Phase 4 96946-41-7
3
Cosyntropin Approved Phase 4 16960-16-0 16129617
4
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
5
Formaldehyde Approved, Vet_approved Phase 4 50-00-0 712
6
Minocycline Approved, Investigational Phase 4 10118-90-8 5281021
7
Isotretinoin Approved Phase 4 4759-48-2 5282379 5538
8
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
9
Lymecycline Approved, Investigational Phase 4 992-21-2 5280963
10 Racepinephrine Approved Phase 4 329-65-7
11
Atracurium Phase 4 64228-79-1 47319
12 diuretics Phase 4,Phase 3,Phase 2,Phase 1
13 Cholinergic Agents Phase 4
14 Cholinergic Antagonists Phase 4
15 Natriuretic Agents Phase 4,Phase 3,Phase 2,Phase 1
16 Neuromuscular Agents Phase 4
17 Neuromuscular Blocking Agents Phase 4
18 Neuromuscular Nondepolarizing Agents Phase 4
19 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Early Phase 1
20 Vasoconstrictor Agents Phase 4,Phase 2
21 Anesthetics Phase 4,Phase 2,Phase 3
22 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
23 Pharmaceutical Solutions Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
24 (1-6)-alpha-glucomannan Phase 4
25 Hormone Antagonists Phase 4,Phase 3,Phase 2
26 Dermatologic Agents Phase 4,Phase 3
27 Hormones Phase 4,Phase 3,Phase 2
28 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2
29 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1
30 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
31 Epinephryl borate Phase 4
32 Manna Nutraceutical Phase 4
33
Quinine Approved Phase 2, Phase 3 130-95-0 3034034 8549
34
Dexmedetomidine Approved, Vet_approved Phase 3,Phase 2 76631-46-4, 113775-47-6 5311068 56032 68602
35
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2 50-02-2 5743
36
Aspirin Approved, Vet_approved Phase 2, Phase 3 50-78-2 2244
37
Rifampin Approved Phase 3 13292-46-1 5381226 5458213
38
Acetaminophen Approved Phase 2, Phase 3,Phase 1 103-90-2 1983
39
Ibuprofen Approved Phase 2, Phase 3 15687-27-1 3672
40
Naproxen Approved, Vet_approved Phase 2, Phase 3 22204-53-1 156391 1302
41
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2 22916-47-8 4189
42
Acetazolamide Approved, Vet_approved Phase 2, Phase 3 59-66-5 1986
43
Codeine Approved, Illicit Phase 2, Phase 3 76-57-3 5284371
44
Clindamycin Approved, Vet_approved Phase 3 18323-44-9 29029
45
Guaifenesin Approved, Investigational, Vet_approved Phase 2, Phase 3 93-14-1 3516
46
Esmolol Approved Phase 3 81147-92-4, 103598-03-4 59768
47
Etoposide Approved Phase 3 33419-42-0 36462
48
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
49
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
50
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741

Interventional clinical trials:

(show top 50) (show all 181)

# Name Status NCT ID Phase Drugs
1 Treatment of Intracranial Hypertension of Severe Tramatic Brain Injured Patients. Physiopathologic Effects of Neuromuscular Blocking Agents Unknown status NCT02404779 Phase 4 cisatracurium besilate
2 Comparison of 20% Mannitol and 3% Hypertonic Saline for Cerebral Relaxation During Elective Supratentorial Craniotomies Unknown status NCT01745081 Phase 4 20% mannitol bolus administration;Hypertonic saline 3% bolus administration
3 Mannitol Versus Hypertonic Saline Solution in the Treatment of Elevated Intracranial Pressure Completed NCT00447018 Phase 4 20% mannitol;7.45% hypertonic saline solution
4 Correlation of Measured and Calculated Serum Osmolality During Hyperosmolar Drugs Infusion in Patients After Craniotomy Completed NCT02037815 Phase 4 20% mannitol solution, 125 ml, IV infusion in 15 min;3.1% sodium chloride solution, 125 ml, IV infusion in 15 min
5 Mannitol Improves Cerebral Oxygen Saturation Completed NCT02091180 Phase 4 Mannitol;Control
6 Cosyntropin Versus Epidural Blood Patch (EBP) for Treatment of Treatment of Post Dural Puncture Headache Completed NCT02394457 Phase 4 Cosyntropin
7 A Post Marketing Surveillance Study for NutropinAq® in Adults With Growth Hormone Deficiency Completed NCT00455884 Phase 4
8 Antiacne Medications Pseudotumor Cerebri Recruiting NCT02149615 Phase 4
9 SOLFAMU Study of Nasal Brushing Collected OLFActory MUcosa Samples in the Diagnosis of Human Encephalopathies Recruiting NCT02951559 Phase 4
10 Comparison of 2 Doses of Mannitol on Post Traumatic Intracranial Hypertension and Cerebral Monitoring Terminated NCT00795587 Phase 4 variation of mannitol dose
11 Cerebral Hemodynamic Effects of Hypertonic Solutions in Severely Head-Injured Patients Terminated NCT00125229 Phase 4 Mannitol;Hypertonic Saline
12 Effect of Intrathoracic Pressure Regulation on Traumatic Brain Injury Terminated NCT01824589 Phase 4
13 ShuntCheck Accuracy in Detecting Shunt Obstruction Normal Pressure Hydrocephalus (NPH) Patients Withdrawn NCT00793416 Phase 4
14 Clinical Value of Noninvasive Intracranial Pressure Measurement Unknown status NCT02130219 Phase 2, Phase 3
15 The DECRA Trial: Early Decompressive Craniectomy in Patients With Severe Traumatic Brain Injury Unknown status NCT00155987 Phase 3
16 Randomized Trial of Erythropoietin During Cerebral Malaria Unknown status NCT00697164 Phase 2, Phase 3 Placebo;Erythropoietin
17 Mannitol as Adjunct Therapy for Childhood Cerebral Malaria Unknown status NCT00113854 Phase 3 Mannitol
18 Idiopathic Intracranial Hypertension Treatment Trial Completed NCT01003639 Phase 2, Phase 3 Acetazolamide;Placebo
19 Preventive Sodium Lactate and Traumatic Brain Injury Completed NCT00995683 Phase 2, Phase 3 half molar sodium lactate;isotonic sodium chloride
20 Impact of Ventricular Catheter Used With Antimicrobial Agents on Patients With a Ventricular Catheter Completed NCT00286104 Phase 3
21 Anti-Oxidant Supplementation for the Prevention of Acute Mountain Sickness Completed NCT00664001 Phase 3
22 Continuous Hyperosomolar Therapy for Traumatic Brain-injured Patients Recruiting NCT03143751 Phase 3 NaCl20% (Continuous hyperosmolar therapy)
23 Esmolol Versus Dexmedetomidine During Intracranial Procedures Recruiting NCT02563288 Phase 3 Esmolol;Dexmedetomidine
24 Treatment Protocol for Hemophagocytic Lymphohistiocytosis 2004 Active, not recruiting NCT00426101 Phase 3 Dexamethasone;Etoposide;Cyclosporin
25 Comparison of Effectiveness of Pentobarbital and Thiopental in Patients With Refractory Intracranial Hypertension Terminated NCT00622570 Phase 3 Pentobarbital;thiopental
26 Mannitol vs HS to Treat ICHT After Severe TBI : Comparison on PtiO2 and Microdialysis Values Terminated NCT01028339 Phase 3 Hypertonic saline;Mannitol
27 Sodium-Lactate and Traumatic Brain Injury Terminated NCT00319345 Phase 2, Phase 3 Mannitol, Sodium-Lactate
28 Hypertonic Saline vs. Mannitol for Elevated Intercranial Pressure Terminated NCT01111682 Phase 3 Mannitol;Hypertonic Saline
29 Normal Pressure Hydrocephalus Treatment by Acetazolamide Terminated NCT02163330 Phase 3 Acetazolamide;sugar pill
30 Clinical Trial of Growth Hormone in MPS I, II, and VI Terminated NCT00748969 Phase 2, Phase 3 Somatropin (DNA origin)
31 Hypothermia in Children After Trauma Terminated NCT00222742 Phase 3
32 Intraventricular Tissue Plasminogen Activator (tPA) in the Management of Aneurysmal Subarachnoid Hemorrhage Unknown status NCT01098890 Phase 2 Tissue Plasminogen Activator;Placebo
33 Dexmedetomidine-based Sedation in Neurocritical Care Patients Unknown status NCT02252523 Phase 2 Dexmedetomidine
34 Study the Safety and Efficacy of Bone Marrow Derived Autologous Cells for the Treatment of Optic Nerve Disease Unknown status NCT01834079 Phase 1, Phase 2
35 Impact of Cardiac Blood Flow on Cerebral Blood Flow in Patients With Severe Traumatic Brain Injury Unknown status NCT02019810 Phase 2 Norepinephrine;Dobutamine and norepinephrine
36 Ketamine and Glutamate After Brain Injury : a Microdialysis Study Unknown status NCT02232347 Phase 2 Ketamine;Sufentanil
37 Safety and Effectiveness of 11b-Hydroxysteroid Dehydrogenase Type 1 Inhibitor (AZD4017) to Treat Idiopathic Intracranial Hypertension. Completed NCT02017444 Phase 2 AZD4017
38 Dexamethasone in Cryptococcal Meningitis Completed NCT00000776 Phase 2 Flucytosine;Fluconazole;Amphotericin B;Dexamethasone
39 Astragalus Membranaceus for Brain Edema Induced by Hemorrhagic Stroke Completed NCT01428401 Phase 2 Chinese Herb Astragalus membranaceus
40 HyperHAES Versus Placebo - Effect on Intracranial Pressure in SAH Patients Completed NCT00199706 Phase 2 7.2% NaCl in 6% hydroxyethyl starch solution
41 Brain Tissue Oxygen Monitoring in Traumatic Brain Injury (TBI) Completed NCT00974259 Phase 2
42 Effects of Saline on Circulation in Children Completed NCT01668277 Phase 2 7.2% NaCl;0.9% NaCl
43 A Pilot Study: Safety & TOlerability of Hypertonic Saline Administration Via IntraOsseous Access Recruiting NCT03276494 Phase 2 injection of intraosseous hypertonic saline
44 Ceftolozane Tazobactam Pharmacokinetics in Infected Critically Ill Patients With an Indwelling External Ventricular Drain Not yet recruiting NCT03309657 Phase 1, Phase 2 Ceftolozane/tazobactam
45 Hypertension, Intracranial Pulsatility and Brain Amyloid-beta Accumulation in Older Adults (HIPAC Trial) Not yet recruiting NCT03354143 Phase 2 Standard Care;Intensive Treatment
46 Intravenous Immunoglobulin for Acute Intracranial Hemorrhage Not yet recruiting NCT02782897 Phase 2 Immunoglobulin Therapy
47 WEANING-Study: "Weaning by Early Versus lAte Tracheostomy iN supratentorIal iNtracerebral Bleedings Terminated NCT01176214 Phase 2
48 Hypernatremia for the Prevention and Treatment of Cerebral Edema in Traumatic Brain Injury Withdrawn NCT01605357 Phase 1, Phase 2 Induced, sustained hypernatremia using hypertonic saline;Standard of care (hypertonic saline and mannitol; serum sodium)
49 Study of Stroke Related Edema Treatments Withdrawn NCT01954290 Phase 2 Conivaptan;Hypertonic saline;Mannitol
50 Comparison of Two Different Medications Used to Treat Elevated Intracranial Pressure Unknown status NCT00359697 Phase 1 Hypertonic Saline, Mannitol

Search NIH Clinical Center for Intracranial Hypertension

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: intracranial hypertension

Genetic Tests for Intracranial Hypertension

Anatomical Context for Intracranial Hypertension

MalaCards organs/tissues related to Intracranial Hypertension:

38
Brain, Liver, Bone, Endothelial, Ovary, Testes, Heart

Publications for Intracranial Hypertension

Articles related to Intracranial Hypertension:

(show top 50) (show all 831)
# Title Authors Year
1
A 15-year review of secondary and tertiary optic nerve sheath fenestration for idiopathic intracranial hypertension. ( 29313398 )
2018
2
CTA/V detection of bilateral sigmoid sinus dehiscence and suspected idiopathic intracranial hypertension in unilateral pulsatile tinnitus. ( 29417173 )
2018
3
Idiopathic intracranial hypertension and bariatric surgery: a literature review and a presentation of two cases. ( 29385843 )
2018
4
Papilledema in Idiopathic Intracranial Hypertension. ( 29399792 )
2018
5
Complications of Optic Nerve Sheath Fenestration as a Treatment for Idiopathic Intracranial Hypertension. ( 29420144 )
2018
6
Noninvasive Assessment of Intracranial Pressure Status in Idiopathic Intracranial Hypertension Using Displacement Encoding with Stimulated Echoes (DENSE) MRI: A Prospective Patient Study with Contemporaneous CSF Pressure Correlation. ( 29284598 )
2018
7
Treatment of idiopathic intracranial hypertension via stereotactic placement of biventriculoperitoneal shunts. ( 29393752 )
2018
8
Cisternostomy: Surgical Alternative for Patients with Refractory Posttraumatic Intracranial Hypertension. ( 29433168 )
2018
9
Segmentation error in spectral domain optical coherence tomography measures of the retinal nerve fibre layer thickness in idiopathic intracranial hypertension. ( 29298687 )
2018
10
Analysis of petrous apex meningocele associated with meningioma: is there any relation with chronic intracranial hypertension? ( 29188303 )
2018
11
Idiopathic intracranial hypertension associated with anaemia, secondary to antiretroviral drug in a human immunodeficiency virus positive patient. ( 29283154 )
2018
12
Long-term visual outcome in a Danish population of patients with idiopathic intracranial hypertension. ( 29405582 )
2018
13
Bilateral Venous Sinus Stenosis: Idiopathic Intracranial Hypertension and Endovascular Venous Sinus Stenting: 2-Dimensional Operative Video. ( 29444263 )
2018
14
Intracranial hypertension and cerebral autoregulation: a systematic review and meta-analysis. ( 29421451 )
2018
15
Forgetting the fundoscope - A case of fulminant idiopathic intracranial hypertension causing rapid visual loss. ( 29396063 )
2018
16
Inflammatory gene expression signatures in idiopathic intracranial hypertension: possible implications in microgravity-induced ICP elevation. ( 29354685 )
2018
17
Headache Linked to Intracranial Hypertension and Hypertrophic Pachymeningitis as the Initial and Dominant Presentation of Granulomatosis With Polyangiitis. Case Report and Review of the Recent Literature. ( 29446067 )
2018
18
Pediatric Intracranial Hypertension: a Current Literature Review. ( 29441432 )
2018
19
Idiopathic intracranial hypertension as a presenting sign of adrenal insufficiency. ( 29375882 )
2018
20
Osteoblastoma Mimicking an Idiopathic Intracranial Hypertension Syndrome. ( 28553393 )
2017
21
Transient resolution of venous sinus stenosis after high-volume lumbar puncture in a patient with idiopathic intracranial hypertension. ( 28841117 )
2017
22
Revised disproportionality analysis of Mirena and benign intracranial hypertension. ( 28861212 )
2017
23
Idiopathic intracranial hypertension VISION (venous intervention versus shunting in IIH for optic nerve disc swelling) trial: patient perspective questionnaire. ( 28934871 )
2017
24
Very Low Prevalence of Intracranial Hypertension in Trigonocephaly. ( 28027242 )
2017
25
Chiari Type 1 Malformation-induced Intracranial Hypertension with Diffuse Brain Edema Treated with Foramen Magnum Decompression: A Case Report. ( 29018653 )
2017
26
Role of vitamin A metabolism in IIH: Results from the idiopathic intracranial hypertension treatment trial. ( 28017254 )
2017
27
Bariatric Surgery or Non-surgical Weight Loss for Idiopathic Intracranial Hypertension? A Systematic Review and Comparison of Meta-analyses. ( 27981458 )
2017
28
Stenosis Before Thrombosis - Intracranial Hypertension from Jugular Foramen Stenosis Secondary to Renal Osteodystrophy. ( 28951273 )
2017
29
Assessing the Efficacy and Safety of an 11I^-Hydroxysteroid Dehydrogenase Type 1 Inhibitor (AZD4017) in the Idiopathic Intracranial Hypertension Drug Trial, IIH:DT: Clinical Methods and Design for a Phase II Randomized Controlled Trial. ( 28923789 )
2017
30
Development of an intracranial dural arteriovenous fistula after venous sinus stenting for idiopathic intracranial hypertension. ( 28951386 )
2017
31
Pediatric idiopathic intracranial hypertension - Is the fixed threshold value of elevated LP opening pressure set too high? ( 28838819 )
2017
32
Changes of cortical perfusion in the early phase of subarachnoid bleeding in a rat model and the role of intracranial hypertension. ( 29355383 )
2017
33
Tumor cerebri: Metastatic renal cell carcinoma with dural venous sinus compression leading to intracranial hypertension; a case report. ( 28868187 )
2017
34
Idiopathic intracranial hypertension: Ocular vestibular evoked myogenic potentials as a new evaluation tool. ( 28863360 )
2017
35
Long-term Response of Cerebrospinal Fluid Pressure in Patients with Idiopathic Intracranial Hypertension - A Prospective Observational Study. ( 28904452 )
2017
36
Utility of Intracranial Pressure Monitoring for Diagnosis of Idiopathic Intracranial Hypertension in the Absence of Papilledema. ( 29258930 )
2017
37
Very Low Prevalence of Intracranial Hypertension in Trigonocephaly. ( 28841631 )
2017
38
Audio-Vestibular Findings in Increased Intracranial Hypertension Syndrome. ( 28084997 )
2017
39
Idiopathic Intracranial Hypertension: Prognostic Factors and Multidisciplinary Management. ( 28884026 )
2017
40
Decompressive craniectomy in the management of intracranial hypertension after traumatic brain injury: a systematic review and meta-analysis. ( 28821777 )
2017
41
Shunt Surgery in Idiopathic Intracranial Hypertension Aided by Electromagnetic Navigation. ( 28088808 )
2017
42
Pituitary Apoplexy Mimicking Bacterial Meningitis with Intracranial Hypertension. ( 27756666 )
2017
43
Refractory Intracranial Hypertension: The Role of Decompressive Craniectomy. ( 28806209 )
2017
44
Variation in monitoring and treatment policies for intracranial hypertension in traumatic brain injury: a survey in 66 neurotrauma centers participating in the CENTER-TBI study. ( 28874206 )
2017
45
Cardiovascular risk factors in Chiari malformation and idiopathic intracranial hypertension. ( 28523220 )
2017
46
The Significance of Arachnoid Granulation in Patients With Idiopathic Intracranial Hypertension. ( 28937488 )
2017
47
Comparison of the sagittal sinus cross-sectional area between patients with multiple sclerosis, hydrocephalus, intracranial hypertension and spontaneous intracranial hypotension: a surrogate marker of venous transmural pressure? ( 28679427 )
2017
48
Editorial: The Importance of the Idiopathic Intracranial Hypertension Treatment Trial. ( 28850180 )
2017
49
Management of idiopathic intracranial hypertension in an infant with bilateral congenital cataract and associated comitant sensory esotropia. ( 29044088 )
2017
50
Pediatric Intracranial Hypertension. ( 27940011 )
2017

Variations for Intracranial Hypertension

Expression for Intracranial Hypertension

Search GEO for disease gene expression data for Intracranial Hypertension.

Pathways for Intracranial Hypertension

Pathways related to Intracranial Hypertension according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.05 APOH F2 F3 F5 FGA SERPINC1
2
Show member pathways
12.58 F2 F3 F5 FGA SERPINC1
3 11.92 AQP4 IL1B SSTR1 TNF
4
Show member pathways
11.89 F2 IL1B MTHFR SERPINE1 TNF
5 11.7 AQP1 AQP4 IL1B TNF
6
Show member pathways
11.63 F2 F3 F5 FGA SERPINC1 SERPINE1
7 11.55 F3 IL1B SERPINE1 TNF
8 11.24 F2 F3 F5 FGA SERPINC1 SERPINE1
9 11.04 IL1B MTHFR TNF
10 10.68 IL1B TNF

GO Terms for Intracranial Hypertension

Cellular components related to Intracranial Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.91 APOH AQP1 F2 F3 FGA IL1B
2 endoplasmic reticulum lumen GO:0005788 9.71 F2 F5 FGA SERPINC1
3 external side of plasma membrane GO:0009897 9.67 AQP4 F2 FGA TNF
4 extracellular region GO:0005576 9.61 APOH F2 F3 F5 FGA IL1B
5 platelet alpha granule GO:0031091 9.43 F5 FGA
6 platelet alpha granule lumen GO:0031093 9.33 F5 FGA SERPINE1
7 extracellular space GO:0005615 9.28 APOH F2 F3 F5 FGA IL1B
8 plasma membrane GO:0005886 10.06 AQP1 AQP4 F2 F3 F5 FGA

Biological processes related to Intracranial Hypertension according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.84 F2 F5 FGA SERPINC1
2 positive regulation of angiogenesis GO:0045766 9.78 AQP1 F3 IL1B SERPINE1
3 platelet degranulation GO:0002576 9.76 APOH F5 FGA SERPINE1
4 blood coagulation GO:0007596 9.72 F2 F3 F5 FGA SERPINC1
5 blood coagulation, intrinsic pathway GO:0007597 9.62 APOH F2
6 water transport GO:0006833 9.61 AQP1 AQP4
7 negative regulation of lipid catabolic process GO:0050995 9.61 IL1B TNF
8 positive regulation of interleukin-8 production GO:0032757 9.61 IL1B SERPINE1 TNF
9 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.6 IL1B TNF
10 negative regulation of blood coagulation GO:0030195 9.59 APOH SERPINE1
11 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.58 IL1B TNF
12 plasminogen activation GO:0031639 9.58 APOH FGA
13 regulation of blood coagulation GO:0030193 9.58 APOH F2 SERPINC1
14 positive regulation of chemokine biosynthetic process GO:0045080 9.57 IL1B TNF
15 multicellular organismal water homeostasis GO:0050891 9.56 AQP1 AQP4
16 regulation of establishment of endothelial barrier GO:1903140 9.55 IL1B TNF
17 fibrinolysis GO:0042730 9.54 F2 FGA SERPINE1
18 positive regulation of fever generation GO:0031622 9.52 IL1B TNF
19 sequestering of triglyceride GO:0030730 9.51 IL1B TNF
20 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.49 IL1B TNF
21 positive regulation of blood coagulation GO:0030194 9.43 APOH F2 SERPINE1
22 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.33 FGA IL1B TNF
23 negative regulation of fibrinolysis GO:0051918 9.13 APOH F2 SERPINE1
24 hemostasis GO:0007599 9.02 F2 F3 F5 FGA SERPINC1

Molecular functions related to Intracranial Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 water channel activity GO:0015250 9.16 AQP1 AQP4
2 water transmembrane transporter activity GO:0005372 8.96 AQP1 AQP4
3 protease binding GO:0002020 8.92 F3 SERPINC1 SERPINE1 TNF

Sources for Intracranial Hypertension

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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