MCID: INT076
MIFTS: 25

Intracranial Sinus Thrombosis

Categories: Blood diseases, Cardiovascular diseases

Aliases & Classifications for Intracranial Sinus Thrombosis

MalaCards integrated aliases for Intracranial Sinus Thrombosis:

Name: Intracranial Sinus Thrombosis 12 14
Sinus Thrombosis, Intracranial 41 69

Classifications:



External Ids:

Disease Ontology 12 DOID:3572
MeSH 41 D012851
UMLS 69 C0037198

Summaries for Intracranial Sinus Thrombosis

MalaCards based summary : Intracranial Sinus Thrombosis, also known as sinus thrombosis, intracranial, is related to thrombosis and acute orbital inflammation. An important gene associated with Intracranial Sinus Thrombosis is RHNO1 (RAD9-HUS1-RAD1 Interacting Nuclear Orphan 1). The drugs Apixaban and Asparaginase have been mentioned in the context of this disorder.

Related Diseases for Intracranial Sinus Thrombosis

Diseases related to Intracranial Sinus Thrombosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Related Disease Score Top Affiliating Genes
1 thrombosis 30.1 F3 SERPINC1
2 acute orbital inflammation 10.2 PGBD1 RHNO1
3 orbital cellulitis 10.2 PGBD1 RHNO1
4 orbital disease 10.2 PGBD1 RHNO1
5 anterior cranial fossa meningioma 10.2 F3 RHNO1
6 intestinal impaction 10.2 F3 SERPINC1
7 fournier gangrene 10.2 F3 SERPINC1
8 heparin-induced thrombocytopenia 10.2 F3 SERPINC1
9 leech infestation 10.2 F3 SERPINC1
10 giant hemangioma 10.2 F3 SERPINC1
11 blue toe syndrome 10.2 F3 SERPINC1
12 complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy 10.2
13 intracranial embolism 10.2 F3 SERPINC1
14 angina pectoris 10.2 F3 SERPINC1
15 marantic endocarditis 10.2 F3 SERPINC1
16 purpura fulminans 10.2 F3 SERPINC1
17 korean hemorrhagic fever 10.2 F3 SERPINC1
18 inherited blood coagulation disease 10.2 F3 SERPINC1
19 intracranial thrombosis 10.2 F3 SERPINC1
20 hepatic infarction 10.2 F3 SERPINC1
21 prothrombin deficiency 10.2 F3 SERPINC1
22 factor xii deficiency 10.2 F3 SERPINC1
23 peripheral vertigo 10.2 F3 SERPINC1
24 coronary thrombosis 10.2 F3 SERPINC1
25 hemorrhagic fever 10.2 F3 SERPINC1
26 cranial nerve palsy 10.2 NT5C3A RHNO1
27 intermediate coronary syndrome 10.2 F3 SERPINC1
28 pulmonary immaturity 10.1 F3 SERPINC1
29 factor xi deficiency 10.1 F3 SERPINC1
30 hepatic vascular disease 10.1 F3 SERPINC1
31 protein s deficiency 10.1 F3 SERPINC1
32 vein disease 10.1 F3 SERPINC1
33 hepatic veno-occlusive disease 10.1 F3 SERPINC1
34 hemophilia b 10.1 F3 SERPINC1
35 intracranial hypertension 10.1 F3 SERPINC1
36 factor x deficiency 10.1 F3 SERPINC1
37 blood coagulation disease 10.1 F3 SERPINC1
38 hepatitis a 10.1 F3 SERPINC1
39 thrombophilia due to activated protein c resistance 10.1 F3 SERPINC1
40 placenta disease 10.1 F3 SERPINC1
41 thrombophilia due to thrombin defect 10.1 F3 SERPINC1
42 afibrinogenemia, congenital 10.1 F3 SERPINC1
43 budd-chiari syndrome 10.1 F3 SERPINC1
44 disseminated intravascular coagulation 10.1 F3 SERPINC1
45 thrombocytosis 10.1 F3 SERPINC1
46 antiphospholipid syndrome 10.0 F3 SERPINC1
47 blood platelet disease 10.0 F3 SERPINC1
48 pulmonary embolism 10.0 F3 SERPINC1
49 purpura 10.0 F3 SERPINC1
50 peripheral vascular disease 10.0 F3 SERPINC1

Graphical network of the top 20 diseases related to Intracranial Sinus Thrombosis:



Diseases related to Intracranial Sinus Thrombosis

Symptoms & Phenotypes for Intracranial Sinus Thrombosis

Drugs & Therapeutics for Intracranial Sinus Thrombosis

Drugs for Intracranial Sinus Thrombosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 41)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Apixaban Approved Phase 3 503612-47-3 10182969
2
Asparaginase Approved, Investigational Phase 3 9015-68-3
3
Pegaspargase Approved, Investigational Phase 3 130167-69-0
4
Warfarin Approved Phase 3 81-81-2 54678486 6691
5
Dalteparin Approved Phase 2, Phase 3 9005-49-6
6
Heparin Approved, Investigational Phase 2, Phase 3 9005-49-6 46507594 772
7 Anticoagulants Phase 3,Phase 2
8 Antithrombin III Phase 3
9 Antithrombins Phase 3
10 Factor Xa Inhibitors Phase 3
11 HIV Protease Inhibitors Phase 3
12 Pharmaceutical Solutions Phase 3
13
protease inhibitors Phase 3
14 Serine Proteinase Inhibitors Phase 3
15 Dabigatran Phase 3
16 calcium heparin Phase 2, Phase 3
17 Calcium, Dietary Phase 2, Phase 3
18 Fibrinolytic Agents Phase 2, Phase 3
19 Heparin, Low-Molecular-Weight Phase 2, Phase 3
20 Plasminogen Phase 2, Phase 3
21 Tissue Plasminogen Activator Phase 2, Phase 3
22 serine Nutraceutical Phase 3
23
Estradiol Approved, Investigational, Vet_approved 50-28-2 5757
24
Ethinyl Estradiol Approved 57-63-6 5991
25
Levonorgestrel Approved, Investigational 797-63-7, 17489-40-6 13109
26
Norelgestromin Approved, Investigational 53016-31-2 13752005
27 Contraceptive Agents
28 Contraceptives, Oral
29 Contraceptives, Oral, Combined
30 Estradiol 17 beta-cypionate
31 Estradiol 3-benzoate
32 Estradiol valerate 979-32-8
33 Estrogens
34 Hormone Antagonists
35 Hormones
36 Hormones, Hormone Substitutes, and Hormone Antagonists
37 Ortho Evra
38 Polyestradiol phosphate
39 Ethinyl estradiol, levonorgestrel drug combination
40 Norethindrone acetate, ethinyl estradiol, ferrous fumarate drug combination
41 Norinyl

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Study of the Safety and Effectiveness of Apixaban in Preventing Blood Clots in Children With Leukemia Who Have a Central Venous Catheter and Are Treated With Asparaginase Recruiting NCT02369653 Phase 3 Apixaban
2 A Clinical Trial Comparing Efficacy and Safety of Dabigatran Etexilate With Warfarin in Patients With Cerebral Venous and Dural Sinus Thrombosis (RE-SPECT CVT) Active, not recruiting NCT02913326 Phase 3 Dabigatran etexilate;Warfarin
3 Thrombolysis or Anticoagulation for Cerebral Venous Thrombosis Terminated NCT01204333 Phase 2, Phase 3 Endovascular thrombolysis;Heparin
4 Fast Magnetic Resonance Imaging as Compared to Computed Tomography Scan in Pediatric Orbital Cellulitis Imaging Unknown status NCT02711436
5 Relative Risks for Non-fatal Venous Thromboembolism, Ischemic Stroke and Myocardial Infarction in Users of ORTHO EVRA(Norelgestromin and Ethinyl Estradiol Contraceptive Patch) Compared to Levonorgestrel-containing Oral Contraceptives. Completed NCT00511784
6 Study Of Lybrel In Relation To Venous Thromboembolism Completed NCT01297348 90ug levonorgestrel / 20 ug ethinyl estradiol;Oral Contraceptives containing 20 ug of ethinyl estradiol
7 Impact of Cranioplasty On Cerebral Perfusion Completed NCT01113645
8 Cerebral Venous Sinus Thrombosis: Re-exploration of Clinical Assessment Scales Recruiting NCT03273179
9 Stroke and Cerebrovascular Diseases Registry Recruiting NCT03281590

Search NIH Clinical Center for Intracranial Sinus Thrombosis

Cochrane evidence based reviews: sinus thrombosis, intracranial

Genetic Tests for Intracranial Sinus Thrombosis

Anatomical Context for Intracranial Sinus Thrombosis

Publications for Intracranial Sinus Thrombosis

Articles related to Intracranial Sinus Thrombosis:

# Title Authors Year
1
A Case of Deep Vein Thrombosis and Intracranial Sinus Thrombosis: Possible rare complications of childhood abdominal tuberculosis. ( 28003904 )
2016
2
WITHDRAWN: Intracranial Sinus Thrombosis in Anorexia Nervosa. ( 20659740 )
2010
3
Successful management of an extensive intracranial sinus thrombosis in a patient undergoing IVF: case report and review of literature. ( 17349640 )
2007
4
Thunderclap headache: presentation of intracranial sinus thrombosis? ( 12887960 )
2003
5
Intracranial sinus thrombosis in a patient with Crohn disease and factor V Leiden mutation. ( 12873183 )
2003
6
Intracranial sinus thrombosis secondary to ear disease in an adolescent. ( 9176806 )
1997
7
Open thrombectomy combined with thrombolysis in massive intracranial sinus thrombosis. ( 7847137 )
1994
8
Cerebral infarction due to intracranial sinus thrombosis. ( 5835445 )
1965

Variations for Intracranial Sinus Thrombosis

Expression for Intracranial Sinus Thrombosis

Search GEO for disease gene expression data for Intracranial Sinus Thrombosis.

Pathways for Intracranial Sinus Thrombosis

GO Terms for Intracranial Sinus Thrombosis

Biological processes related to Intracranial Sinus Thrombosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hemostasis GO:0007599 8.62 F3 SERPINC1

Molecular functions related to Intracranial Sinus Thrombosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 8.62 F3 SERPINC1

Sources for Intracranial Sinus Thrombosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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