Intractable Epilepsy malady

MalaCards: Intractable Epilepsy, also known as refractory epilepsy, is related to tuberous sclerosis and generalized epilepsy with febrile seizures plus. An important gene associated with Intractable Epilepsy is HSPBAP1 (HSPB (heat shock 27kDa) associated protein 1), and among its related pathways are Signal transduction_PTEN pathway and Regulation of lipid metabolism Insulin signaling-generic cascades. The compounds carbamazepine and threonine have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and monocytes, and related mouse phenotypes are respiratory system and endocrine/exocrine gland.

intractable epilepsy 8 refractory epilepsy 43

Diseases related to intractable epilepsy by text searches and GeneDecks gene sharing:

(show top 50)    (show all 224)

id	Related Disease	Score	Top Affiliating Genes
1	tuberous sclerosis	29.7	TSC1, TSC2
2	generalized epilepsy with febrile seizures plus	28.9	SCN2A, SCN1A, ARX, ABCB1
3	dysembryoplastic neuroepithelial tumor	28.9	GRIN1, ABCC2, ABCC5, ABCG2, GFAP, NES
4	focal cortical dysplasia	27.6	VEGFA, CDK5, GRIN1, GRM5, SV2A, GFAP
5	temporal lobe epilepsy	27.1	BDNF, GRIN1, GRM1, GRM5, NTRK2, ABCB1
6	thyroiditis	21.6	VEGFA, LAMB1, CDK5, INSR, GSR, MED1
7	neuronitis	18.6	VEGFA, BLVRB, BDNF, SCN2A, SCN1A, LAMB1
8	early myoclonic encephalopathy	13.6	SCN1A, CDKL5, ARX
9	epilepsy with generalized tonic-clonic seizures	13.6	SCN2A, SCN1A
10	seizure disorder	13.5	SCN2A, SCN1A, CDKL5
11	subependymoma	13.5	TSC2, NES
12	lymphangioleiomyomatosis	13.4	TSC1, TSC2
13	infantile epileptic encephalopathy	13.4	CDKL5, ARX, TSC1, TSC2
14	focal epilepsy	13.3	SCN1A, GRIN1, TSC1, TSC2
15	aicardi-goutieres syndrome	13.3	SCN1A, CDKL5, ARX, TSC2
16	subependymal giant cell astrocytoma	13.2	GFAP, TSC1, TSC2, NES
17	pulmonary plasma cell granuloma	13.2	GRIN1, ABCC2, ABCG2, TSC2
18	epilepsies, partial	13.1	SCN1A, GRM1, GRM5, TSC1
19	severe myoclonic epilepsy of infancy (smei)	13.1	SCN2A, SCN1A
20	cystic kidney	13.0	MAPK1, TSC1, TSC2
21	hydrocephalus	13.0	BDNF, AQP1, GFAP, TSC1, NES
22	convulsions	13.0	BLVRB, BDNF, SCN2A, SCN1A, GRM5
23	anaplastic ganglioglioma	13.0	GFAP, NES
24	polycystic kidney disease, autosomal dominant	12.9	AQP1, MAPK1, TSC1, TSC2
25	drug addiction	12.9	BDNF, GRM5, MAPK1
26	ring chromosome 7	12.9	EGFR, GFAP
27	autism spectrum disorder	12.8	BDNF, LAMB1, GFAP, TSC1, TSC2, SLC6A8
28	angiofibroma	12.8	VEGFA, GFAP, TSC1, TSC2
29	autistic disorder	12.8	BDNF, CDKL5, ARX, GRM5, TSC1, TSC2
30	mental retardation syndrome	12.8	BDNF, CDKL5, ARX, GRM5, TSC1, TSC2
31	prion disease	12.8	BDNF, CDK5, GRIA2, NTRK2, GFAP
32	central neurocytoma	12.8	GFAP, NES
33	pleomorphic xanthoastrocytoma	12.7	EGFR, GFAP, TSC1
34	polycystic kidney disease	12.7	MAPK1, TSC1, TSC2
35	albinism	12.7	BLVRB, GSR, GRM1, GRM5, GFAP
36	hemangioma of lung	12.7	EGFR, TSC1, TSC2
37	neuroectodermal tumors	12.7	MAPK3, NTRK2, EIF2AK3, GFAP, NES
38	vascular malformations	12.7	VEGFA, CCL2, NES
39	peutz-jeghers syndrome	12.6	EGFR, TSC1, TSC2, STRADA
40	benign tumors	12.6	MAPK3, MAPK1, TSC1, TSC2
41	fragile x syndrome	12.6	BDNF, GRM1, GRM5, MAPK1, SLC6A8
42	kidney cancer	12.5	VEGFA, AQP1, ABCB1, ABCC2, TSC2
43	central nervous system lymphoma	12.5	VEGFA, CCL2, ABCC2, ABCG2
44	cerebral artery occlusion	12.5	VEGFA, BDNF, MAPK1, NES
45	central nervous system disease	12.5	BDNF, GRM1, GRM5, CCL2, GFAP
46	mesangial proliferative glomerulonephritis	12.5	VEGFA, MAPK1, CCL2
47	chordoma	12.5	VEGFA, ABCB1, GFAP, TSC1
48	idiopathic interstitial pneumonia	12.5	VEGFA, BDNF, CCL2
49	pick's disease	12.4	BDNF, GRM1, MAPK3, MAPK1
50	photosensitive trichothiodystrophy	12.4	BDNF, INSR, GSR, ABCB1, GFAP

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to intractable epilepsy:

²²

MGI Mouse Phenotypes related to intractable epilepsy:

²⁵ (show all 16)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	9.7	CDK5, SLC12A5, MED1, INSR, BDNF
2	endocrine/exocrine gland phenotype	MP:0005379	9.2	ARX, MED1, AQP1, SYT1, GRM5
3	integument phenotype	MP:0010771	8.5	CDK5, BDNF, ABCG2, ARX, MED1, GRIA2
4	liver/biliary system phenotype	MP:0005370	8.5	TSC2, ABCB1, EGFR, MED1, VEGFA
5	hearing/vestibular/ear phenotype	MP:0005377	8.2	NTRK2, SLC12A5, AQP1, EGFR, GRIN1, GRIA2
6	normal phenotype	MP:0002873	7.7	GFAP, NTRK2, SV2A, GRIN1, GRIA2, GSR
7	reproductive system phenotype	MP:0005389	7.3	GRM1, GRM5, MAPK1, CCL2, TSC1, GRIN1
8	vision/eye phenotype	MP:0005391	6.7	GRM1, VEGFA, BDNF, MED1, GRIN1, AQP1
9	muscle phenotype	MP:0005369	6.6	GFAP, INSR, VEGFA, ARX, TSC1, EGFR
10	cardiovascular system phenotype	MP:0005385	5.5	GSR, MED1, GRIN1, AQP1, MAPK3, MAPK1
11	nervous system phenotype	MP:0003631	5.2	BDNF, SV2A, NTRK2, EGFR, EIF2AK3, TSC1
12	behavior/neurological phenotype	MP:0005386	4.8	ARX, NTRK2, ABCB1, EIF2AK3, TSC1, GFAP
13	cellular phenotype	MP:0005384	4.8	TSC1, NTRK2, SV2A, CCL2, MAPK1, MAPK3
14	homeostasis/metabolism phenotype	MP:0005376	4.3	NTRK2, SLC6A8, TSC2, GRIN1, GRIA2, MED1
15	growth/size phenotype	MP:0005378	4.3	AQP1, NES, SLC12A5, SLC6A8, GRM1, GRIN1
16	mortality/aging	MP:0010768	4.2	AQP1, GRM1, TSC1, GRIN1, GRIA2, ARX

Articles related to intractable epilepsy:

(show all 28)

id	Title	Authors	Year	Affiliating Genes
1	Association analysis of intractable epilepsy with C34 35T and G2677T/A ABCB1 gene polymorphisms in Iranian patients. (21636342)	Sayyah M.... Shamshiri A.R.	2011	ABCB1
2	Treatment of intractable epilepsy in a female with SL C6A8 deficiency. (20846889)	Mercimek-Mahmutoglu S.... Stockler-Ipsiroglu S.	2010	SLC6A8
3	Increased insulin receptor expression in anterior tem poral neocortex of patients with intractable epilepsy. (20624623)	Wang L.... Wang X.	2010	INSR
4	De novo mutations of voltage-gated sodium channel alp haII gene SCN2A in intractable epilepsies. (19786696)	Ogiwara I.... Yamakawa K.	2009	SCN2A
5	Gene expression analysis on anterior temporal neocort ex of patients with intractable epilepsy. (19623530)	Xi Z.Q.... Liu G.W.	2009	CDK5, MED1
6	Re: CDKL5 mutations in boys with severe encephalopath y and early-onset intractable epilepsy. (19564592)	Fichou Y.... Bienvenu T.	2009	CDKL5
7	Nestin in the temporal neocortex of the intractable epilepsy patients. (18719994)	Wang L.... Xiao Z.	2009	NES
8	Down-regulation synaptic vesicle protein 2A in the an terior temporal neocortex of patients with intractable epilepsy. (19757204)	Feng G.... Wang X.	2009	SV2A
9	Up-regulation of epithelial membrane protein-1 in the temporal neocortex of patients with intractable epilepsy. (19288191)	Li Y.Q.... Yao L.	2009	EGFR, EMP1
10	Increased expression of aquaporin-1 in the anterior temporal neocortex of patients with intractable epilepsy. (18544259)	Zhou S.... Liu K.	2008	AQP1
11	Research on distribution and expression of NMDA receptors and parvalbumin-positive neurons in intractable epilepsy-related focal cortical dysplasia (18509979)	Liu L.... Lu D.H.	2008	GRIN1
12	Expression of monocyte chemoattractant protein-1 in brain tissue of patients with intractable epilepsy. (18402383)	Wu Y.... Zhang J.	2008	CCL2
13	CDKL5 mutations in boys with severe encephalopathy and early-onset intractable epilepsy. (18809835)	Elia M.... Fichera M.	2008	CDKL5
14	Expression of laminin beta1 in hippocampi of patients with intractable epilepsy. (18691630)	Wu Y.... Zheng J.O.	2008	LAMB1
15	Altered distribution of KCC2 in cortical dysplasia in patients with intractable epilepsy. (17284302)	Munakata M.... Tsuchiya S.	2007	SLC12A5
16	NADPH diaphorase reactive neurons in temporal lobe cortex of patients with intractable epilepsy and hippocampal sclerosis. (17412562)	D'Alessio L.... Zieher L.M.	2007	BLVRB
17	TDAG51 in the anterior temporal neocortex of patients with intractable epilepsy. (17870236)	Xi Z.Q.... Wang X.F.	2007	PHLDA1
18	HSPBAP1 is found extensively in the anterior temporal neocortex of patients with intractable epilepsy. (17568411)	Xi Z.Q.... Guan L.F.	2007	HSPBAP1
19	Extracellular signal-regulated protein kinase in human intractable epilepsy. (17662006)	Xi Z.Q.... Guan L.F.	2007	MAPK3, MAPK1, EIF2AK3
20	Expression of multidrug resistance type 1 gene (MDR1) P-glycoprotein in intractable epilepsy with different aetiologies: a double-labelling and electron microscopy study. (16998727)	Chengyun D.... Qunyuan X.	2006	ABCB1, GFAP
21	Potential role of drug transporters in the pathogenesis of medically intractable epilepsy. (15679503)	Kwan P.... Brodie M.J.	2005	ABCB1
22	A nonsense mutation of the sodium channel gene SCN2A in a patient with intractable epilepsy and mental decline. (15028761)	Kamiya K.... Yamakawa K.	2004	SCN1A, SCN2A
23	Expression of multidrug transporters in dysembryoplastic neuroepithelial tumors causing intractable epilepsy. (15581025)	Vogelgesang S.... Warzok R.W.	2004	ABCG2, ABCC2, ABCC5
24	A case of intractable epilepsy: diagnosis of tuberous sclerosis based on histopathological findings and immunohistochemical expression of hamartin and tuberin (11808208)	Takaishi Y.... Shimizu H.	2002	TSC1, TSC2
25	Expression of brain-derived neurotrophic factor and tyrosine kinase B receptor proteins in glioneuronal tumors from patients with intractable epilepsy: colocalization with N-methyl-D-aspartic acid receptor. (11355310)	Aronica E.... Troost D.	2001	NTRK2, GRIN1, BDNF
26	Ionotropic and metabotropic glutamate receptor protein expression in glioneuronal tumours from patients with intractable epilepsy. (11489142)	Aronica E.... Troost D.	2001	GRIN1, GSR, GRM5
27	Vascular abnormalities in surgical specimens obtained from the resected focus of intractable epilepsy. (11310919)	Hodozuka A.... Tanaka T.	2000	VEGFA
28	MDR1 gene expression in brain of patients with medically intractable epilepsy. (8001500)	Tishler D.M.... Raffel C.	1995	ABCB1

Genes related to intractable epilepsy according to GeneCards:

(show all 42)

id	Symbol	Description	Score	GeneCards Section Context
1	HSPBAP1	HSPB (heat shock 27kDa) associated protein 1	11.1	Publications, Summaries
2	PHLDA1	pleckstrin homology-like domain, family A, member 1	11.0	Publications
3	ARX	aristaless related homeobox	11.0
4	SLC6A8	solute carrier family 6 (neurotransmitter transporter, creatine), member 8	11.0	Publications
5	EMP1	epithelial membrane protein 1	11.0	Publications
6	SV2A	synaptic vesicle glycoprotein 2A	11.0	Publications
7	PPFIA3	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3	11.0
8	SLC12A5	solute carrier family 12 (potassium/chloride transporter), member 5	11.0	Publications
9	GRIN1	glutamate receptor, ionotropic, N-methyl D-aspartate 1	11.0	Publications
10	STRADA	STE20-related kinase adaptor alpha	11.0
11	CDKL5	cyclin-dependent kinase-like 5	11.0	Publications
12	ATP5H	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d	11.0
13	LAMB1	laminin, beta 1	11.0	Publications
14	TSC1	tuberous sclerosis 1	11.0	Publications
15	MED1	mediator complex subunit 1	11.0	Publications
16	NES	nestin	11.0	Publications
17	ABCC5	ATP-binding cassette, sub-family C (CFTR/MRP), member 5	11.0	Publications
18	BLVRB	biliverdin reductase B (flavin reductase (NADPH))	11.0	Publications
19	SCN2A	sodium channel, voltage-gated, type II, alpha subunit	11.0	Publications
20	AQP1	aquaporin 1 (Colton blood group)	11.0	Publications
21	EIF2AK3	eukaryotic translation initiation factor 2-alpha kinase 3	11.0	Publications
22	CDK5	cyclin-dependent kinase 5	11.0	Publications
23	GRIA2	glutamate receptor, ionotropic, AMPA 2	11.0	Publications
24	SCN1A	sodium channel, voltage-gated, type I, alpha subunit	11.0	Publications
25	PPFIA1	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1	11.0
26	ABCC2	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	11.0	Publications
27	TSC2	tuberous sclerosis 2	11.0	Publications
28	BDNF	brain-derived neurotrophic factor	11.0	Publications
29	ABCG2	ATP-binding cassette, sub-family G (WHITE), member 2	11.0	Publications
30	GSR	glutathione reductase	11.0	Publications
31	NTRK2	neurotrophic tyrosine kinase, receptor, type 2	11.0	Publications
32	GRM5	glutamate receptor, metabotropic 5	11.0	Publications
33	INSR	insulin receptor	11.0	Publications
34	GRM1	glutamate receptor, metabotropic 1	11.0	Publications
35	MAPK3	mitogen-activated protein kinase 3	11.0	Publications
36	GFAP	glial fibrillary acidic protein	11.0	Publications
37	ABCB1	ATP-binding cassette, sub-family B (MDR/TAP), member 1	11.0	Publications
38	SYT1	synaptotagmin I	11.0
39	CCL2	chemokine (C-C motif) ligand 2	11.0	Publications
40	MAPK1	mitogen-activated protein kinase 1	11.0	Publications
41	VEGFA	vascular endothelial growth factor A	11.0	Publications
42	EGFR	epidermal growth factor receptor	11.0	Publications

Pathways related to intractable epilepsy according to GeneDecks:

(show top 50)    (show all 87)

id	Pathway	Score	Top Affiliating Genes
1	Signal transduction_PTEN pathway41	10.4	TSC2
2	Regulation of lipid metabolism Insulin signaling-generic cascades10	10.3	MAPK3
3	CDK5 Pathway36	10.1	NTRK2, LAMB1, BDNF, CDK5
4	Pravastatin Pathway, Pharmacokinetics34	10.0	ABCG2, ABCB1, ABCC2
5	Translation _Regulation of EIF2 activity41	10.0	INSR, MAPK1
6	Methotrexate Pathway, Pharmacokinetics34	9.9	ABCG2, ABCC2, ABCB1
7	Glutamic acid signaling10	9.9	GRM1, GRM5, GRIA2, GRIN1
8	Taxane Pathway, Pharmacokinetics34	9.9	ABCB1, ABCC2, ABCG2
9	Irinotecan Pathway, Pharmacokinetics34	9.9	ABCB1, ABCG2, ABCC2
10	Irinotecan Pathway, Pharmacodynamics34	9.9	ABCG2, ABCC2, ABCB1
11	ABC transporters20	9.8	ABCB1, ABCC2, ABCC5, ABCG2
12	Erlotinib Pathway, Pharmacokinetics34	9.7	EGFR, ABCB1, ABCG2
13	Transcription PPAR Pathway10	9.6	MAPK3, MAPK1, MED1
14	Transcription Receptor-mediated HIF regulation10	9.4	TSC2, MAPK1, MAPK3, INSR
15	BDNF Pathway36	9.4	MAPK3, NTRK2, MAPK1, BDNF
16	Development_Neurotrophin family signaling41	9.3	BDNF, MAPK3, MAPK1, NTRK2
17	Development Neurotrophin family signaling10	9.3	MAPK1, NTRK2, MAPK3, BDNF
18	Transcription_PPAR Pathway41	9.3	MAPK1, MED1, INSR, MAPK3
19	Alzheimers disease20	9.3	MAPK1, EIF2AK3, GRIN1, CDK5, ATP5H, MAPK3
20	Translation_Insulin regulation of translation41	9.3	MAPK1, TSC2, INSR, TSC1, MAPK3
21	Long-term depression20	9.1	MAPK1, MAPK3, GRM5, GRIA2, GRM1
22	Regulation of lipid metabolism_Insulin signaling-generic cascades41	9.1	MAPK3, INSR, TSC2, MAPK1
23	Long-term potentiation20	9.0	GRIA2, GRIN1, GRM1, MAPK3, GRM5, MAPK1
24	Translation _Regulation of EIF4F activity41	9.0	EGFR, MAPK1, TSC1, MAPK3, TSC2
25	Alzheimers Disease Pathway36	9.0	INSR, MAPK1, EGFR, CDK5, NTRK2
26	Glutamatergic synapse20	9.0	MAPK1, GRM5, GRIA2, GRM1, GRIN1, MAPK3
27	Glioblastoma Multiforme36	9.0	TSC1, TSC2, MAPK3, MAPK1, EGFR
28	Neuroscience3	9.0	NTRK2, GFAP, SYT1, GRIN1, CDK5, GRM1
29	mTOR Pathway36	9.0	MAPK3, BDNF, TSC2, TSC1, INSR, MAPK1
30	Signal transduction PTEN pathway10	9.0	MAPK3, EGFR, TSC2, MAPK1
31	Translation Regulation activity of EIF210	8.9	EIF2AK3, MAPK1, INSR, MAPK3, EGFR
32	Development Endothelin-1/EDNRA transactivation of EGFR10	8.8	MAPK1, MAPK3, TSC2, EGFR
33	Gap junction20	8.8	MAPK3, GRM1, MAPK1, EGFR, GRM5
34	Development_Endothelin-1/EDNRA transactivation of EGFR41	8.8	MAPK1, EGFR, TSC2, MAPK3
35	mTOR signaling pathway20	8.7	TSC2, TSC1, MAPK3, VEGFA, MAPK1, STRADA
36	Transcription_Receptor-mediated HIF regulation41	8.6	MAPK1, TSC2, VEGFA, MAPK3, INSR
37	Bladder cancer20	8.5	VEGFA, MAPK3, MAPK1, EGFR
38	Nanog in Mammalian ESC Pluripotency36	8.5	INSR, MAPK3, MAPK1, NTRK2, EGFR, BDNF
39	Development VEGF signaling via VEGFR2 - generic cascades10	8.5	VEGFA, CCL2, MAPK3, MAPK1
40	eIF2 Pathway36	8.4	NTRK2, MAPK1, EIF2AK3, EGFR, MAPK3, INSR
41	GSK3 Signaling36	8.4	BDNF, INSR, EIF2AK3, MAPK3, EGFR, MAPK1
42	Neuropathic Pain-Signaling in Dorsal Horn Neurons36	8.4	SCN1A, BDNF, NTRK2, MAPK1, MAPK3, GRM5
43	14-3-3 Induced Intracellular Signaling36	8.3	BDNF, TSC1, EGFR, NTRK2, MAPK1, MAPK3
44	Molecular Mechanisms of Cancer36	8.2	TSC2, TSC1, EGFR, INSR, BDNF, NTRK2
45	CREB Pathway36	8.1	NTRK2, BDNF, EGFR, MAPK1, GRIA2, MAPK3
46	Endothelin-1 Signaling Pathway36	8.1	INSR, MAPK3, MAPK1, EGFR, NTRK2
47	p70S6K Signaling36	8.1	BDNF, MAPK3, MAPK1, NTRK2, EGFR, INSR
48	Renin-Angiotensin Pathway36	8.0	NTRK2, CCL2, MAPK1, MAPK3, EGFR, BDNF
49	JAK-STAT Pathway36	7.9	EGFR, CCL2, NTRK2, MAPK1, INSR, MAPK3
50	Rho Family GTPases36	7.6	LAMB1, GFAP, EGFR, NTRK2, CCL2, MAPK3

Compounds related to intractable epilepsy according to GeneDecks:

(show top 50)    (show all 167)

id	Compound	Score	Top Affiliating Genes
1	carbamazepine32 34 9 9	13.0	GSR, SCN1A
2	threonine32	9.8	GRM5, SYT1, CDK5
3	gnrh32	9.8	NTRK2, BLVRB, CCL2, NES
4	n acetylcysteine32	9.8	EGFR, CDK5, ABCC2, BDNF
5	mk 57132 42	10.7	ABCG2, ABCC2, ABCC5, ABCB1
6	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid32	9.5	GRM5, GRM1, GRIA2, GRIN1, BDNF, GSR
7	glucose32	9.4	AQP1, TSC1, CDK5, TSC2, LAMB1, BLVRB
8	oatp32	9.3	ABCG2, ABCB1, MAPK3, ABCC2
9	cocaine32 9 9	11.2	GFAP, GRM5, GRIN1, GRIA2, GSR, CDK5
10	arsenic trioxide34 9 9	11.1	ABCC2, ABCB1, MAPK1, MAPK3
11	morphine32 9 9	11.0	ABCB1, MAPK3, GRIN1, GRIA2, CDK5, ABCC2
12	alanine32	9.0	EMP1, ARX, INSR, MED1, MAPK3, ABCG2
13	ly29400232	8.7	CCL2, TSC2, MAPK1, VEGFA
14	aspartate32	8.7	NTRK2, GFAP, SYT1, GRM5, GRM1, GSR
15	sunitinib32 9 9	10.6	ABCG2, ABCC2, VEGFA, ABCB1, EGFR
16	taxane32	8.6	ABCG2, ABCC2, ABCB1, EGFR, VEGFA
17	kainate32	8.6	GRIA2, BDNF, BLVRB, GSR, GRM1, GRIN1
18	arginine32	8.5	GSR, SLC6A8, GFAP, ABCC2, MAPK3, GRIA2
19	rapamycin32 42	9.5	EGFR, TSC2, BDNF, CDK5, EIF2AK3, VEGFA
20	carboplatin32 34 9 9	11.3	EGFR, ABCG2, ABCC2, GSR, VEGFA, ABCB1
21	quercetin32 42 9 18 9	12.3	MAPK1, MAPK3, ABCC2, ABCB1, GSR, GFAP
22	oxygen32 18	9.2	GFAP, EIF2AK3, NTRK2, MAPK1, GRIN1, BLVRB
23	topotecan32 9 9	10.2	ABCB1, VEGFA, EGFR, ABCG2, ABCC2
24	dopamine32 9 18 9	11.1	NES, BLVRB, GRM1, GRM5, INSR, GRIN1
25	erlotinib32 34 9 9	11.0	VEGFA, MAPK1, EGFR, ABCB1, ABCG2
26	sorafenib32 9 9	9.9	ABCB1, ABCC2, ABCG2, EIF2AK3, VEGFA, EGFR
27	doxorubicin32 34 9 9	10.7	VEGFA, BDNF, GSR, EGFR, ABCB1, ABCC2
28	gaba32 42	8.7	SYT1, NES, SLC12A5, GFAP, NTRK2, SV2A
29	paraffin32	7.7	VEGFA, BLVRB, AQP1, EGFR, TSC1, TSC2
30	phosphoinositide32	7.6	GRM1, TSC2, BDNF, NTRK2, EGFR, MAPK3
31	gefitinib32 34 9 9	10.5	VEGFA, EMP1, ABCB1, MAPK1, EGFR, MAPK3
32	nitric oxide32 9 18 9	10.5	BLVRB, GRIN1, GRM5, GRM1, CCL2, AQP1
33	forskolin32 42 9 9	10.5	NTRK2, ABCB1, MAPK1, MAPK3, SYT1, BDNF
34	ang ii32	7.3	EGFR, CCL2, MAPK1, MAPK3, VEGFA
35	pd 98,05932	7.2	MAPK1, CCL2, MAPK3, INSR, CDK5, BDNF
36	testosterone32 9 18 9	10.2	BDNF, ABCG2, INSR, BLVRB, CCL2, NTRK2
37	phosphatidylinositol32	7.1	EGFR, CCL2, INSR, GRIN1, MAPK3, MAPK1
38	curcumin32	7.1	MAPK3, ABCB1, EGFR, ABCG2, CCL2, MAPK1
39	lipid32	7.0	ABCG2, NES, GFAP, TSC2, ABCC2, SYT1
40	paclitaxel32 34 9 9	9.9	GFAP, ABCG2, ABCC2, ABCB1, EGFR, MAPK1
41	glutamate32	6.8	MAPK1, MAPK3, ABCC2, SYT1, SLC12A5, NES
42	nmda32 42	7.8	GSR, GFAP, NTRK2, CCL2, MAPK1, BDNF
43	calcium32 9 18 9	9.7	SV2A, NTRK2, ABCG2, SYT1, SLC12A5, EIF2AK3
44	cycloheximide32	6.5	MAPK1, VEGFA, MAPK3, INSR, BDNF, ABCC2
45	serine32	6.3	EIF2AK3, NTRK2, CCL2, GFAP, TSC1, TSC2
46	genistein32 9 18 9	9.3	ABCG2, ABCB1, EGFR, CCL2, MAPK1, GSR
47	vegf32	6.2	NES, MAPK3, VEGFA, BDNF, INSR, AQP1
48	estrogen32	6.0	VEGFA, BDNF, INSR, GFAP, EIF2AK3, ABCG2
49	cisplatin32 34 9 9	8.9	MAPK3, ABCC5, ABCG2, GFAP, NTRK2, ABCC2
50	tyrosine32	4.4	MAPK1, ABCG2, CDK5, EGFR, NTRK2, SLC12A5

Cellular components related to intractable epilepsy according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	TSC1-TSC2 complex	GO:033596	10.1	TSC1, TSC2
2	growth cone	GO:030426	9.6	TSC1, NTRK2, GRIA2, CDK5
3	postsynaptic density	GO:014069	9.5	CDK5, GRIA2, GRIN1, GRM1, NTRK2
4	integral to plasma membrane	GO:005887	8.3	AQP1, SLC6A8, ABCC5, ABCC2, SCN2A, NTRK2
5	membrane	GO:016020	7.6	TSC1, ABCC5, ABCB1, EGFR, INSR, CDK5
6	plasma membrane	GO:005886	6.2	EMP1, GRIN1, GRIA2, INSR, CDK5, AQP1

Biological processes related to intractable epilepsy according to GeneDecks:

(show all 16)

id	Name	GO ID	Score	Top Affiliating Genes
1	activation of MAPKK activity	GO:000186	10.4	GRM1
2	neuron migration	GO:001764	9.8	NTRK2, ARX, CDKL5, CDK5
3	sensory perception of pain	GO:019233	9.8	MAPK3, CDK5, GRIN1, GRM1
4	glutamate secretion	GO:014047	9.7	SYT1, BDNF, NTRK2
5	regulation of early endosome to late endosome transport	GO:2000641	9.5	MAPK3, MAPK1
6	caveolin-mediated endocytosis	GO:072584	9.4	MAPK3, MAPK1
7	activation of protein kinase activity	GO:032147	9.4	STRADA, INSR, VEGFA
8	transport	GO:006810	9.4	SLC12A5, SLC6A8, ABCG2, ABCC5, ABCC2, ABCB1
9	regulation of Golgi inheritance	GO:090170	9.2	MAPK3, MAPK1
10	protein autophosphorylation	GO:046777	9.2	EIF2AK3, EGFR, INSR, CDKL5, CDK5, NTRK2
11	insulin receptor signaling pathway	GO:008286	9.0	INSR, MAPK3, MAPK1, TSC1, TSC2, STRADA
12	activation of MAPK activity	GO:000187	9.0	MAPK3, GRM1, INSR, MAPK1
13	response to drug	GO:042493	8.9	ABCG2, ABCB1, AQP1, BDNF, NES, CCL2
14	MAPK cascade	GO:000165	8.6	EGFR, CCL2, MAPK1, MAPK3
15	axon guidance	GO:007411	8.6	BDNF, EGFR, MAPK1, MAPK3, ARX, CDK5
16	synaptic transmission	GO:007268	8.5	GRM1, SYT1, SLC12A5, MAPK1, GRM5, CDK5

Molecular functions related to intractable epilepsy according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	transmembrane transporter activity	GO:022857	10.0	SV2A, AQP1, ATP5H
2	ATPase activity, coupled to transmembrane movement of substances	GO:042626	9.9	ABCC2, ABCC5, ABCG2
3	xenobiotic-transporting ATPase activity	GO:008559	9.8	ABCG2, ABCB1
4	glutamate receptor activity	GO:008066	9.8	GRM1, GRM5, GRIA2
5	protein kinase activity	GO:004672	9.1	EIF2AK3, STRADA, CCL2, CDKL5, CDK5
6	ATP binding	GO:005524	6.9	ABCC5, EIF2AK3, ABCG2, ABCC2, ABCB1, EGFR