MCID: INT016
MIFTS: 41

Intraductal Papilloma malady

Cancer diseases category

Summaries for Intraductal Papilloma

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66Wikipedia, 34MalaCards
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Wikipedia:66 Intraductal papillomas of the breast are benign lesions with an incidence of approximately 2-3% in... more...

MalaCards: Intraductal Papilloma, also known as papilloma, intraductal, is related to papillary carcinoma and papilloma. An important gene associated with Intraductal Papilloma is IDH2 (isocitrate dehydrogenase 2 (NADP+), mitochondrial), and among its related pathways are Carbon metabolism and Peroxisome. The compounds Oxalosuccinic acid and Isocitric acid have been mentioned in the context of this disorder. Affiliated tissues include breast, salivary gland and lymph node, and related mouse phenotypes are renal/urinary system and digestive/alimentary.

Aliases & Classifications for Intraductal Papilloma

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9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 36MeSH, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

intraductal papilloma 9 11
papilloma, intraductal 63
papilloma intraductal 46
ductal papilloma 9


External Ids:

Disease Ontology9 DOID:1627
MeSH36 D018300
SNOMED-CT59 5244003
NCIt41 C3785

Related Diseases for Intraductal Papilloma

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Intraductal Papilloma:



Diseases related to intraductal papilloma

Symptoms for Intraductal Papilloma

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Drugs & Therapeutics for Intraductal Papilloma

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Intraductal Papilloma

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Anatomical Context for Intraductal Papilloma

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34MalaCards
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MalaCards organs/tissues related to Intraductal Papilloma:

34
Breast, Salivary gland, Lymph node

Animal Models for Intraductal Papilloma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Intraductal Papilloma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.1CD44, PRKG1, MYH11, TP63
2MP:00053818.1TP63, MYH11, PRKG1, CD44
3MP:00053858.1CD44, PRKG1, MYH11, TP63
4MP:00053698.0TP63, MYH11, PRKG1, CD44
5MP:00053767.3IDH1, TP63, MYH11, PRKG1, CD44

Publications for Intraductal Papilloma

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53PubMed
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Articles related to Intraductal Papilloma:

(show top 50)    (show all 89)
idTitleAuthorsYear
1
Mammotome biopsy in diagnosing and treatment of intraductal papilloma of the breast. (23640929)
2013
2
Intraductal papilloma: atypical presentation. (23762648)
2013
3
Combined evaluation of CK5/6, ER, p63, and MUC3 for distinguishing breast intraductal papilloma from ductal carcinoma in situ. (22612506)
2012
4
Intraductal papilloma of the breast: A case report. (23396758)
2012
5
MRI features of intraductal papilloma of the breast: sheep in wolf's clothing? (21498361)
2011
6
Glucose transporter expression of intraductal papilloma of the breast detected by fluorodeoxyglucose positron emission tomography. (21519997)
2011
7
Is CD56 a specific and reliable neuroendocrine marker for discriminating between endocrine/neuroendocrine ductal carcinoma in situ and intraductal papilloma of the breast? (21166944)
2011
8
Intraductal papilloma of the breast in association with preoncogenic gene of breast cancer. (23569749)
2011
9
Intraductal papilloma of ectopic breast tissue in axillary lymph node of a patient with a previous intraductal papilloma of ipsilateral breast: a case report and review of the literature. (20222992)
2010
10
Evaluation of CD56 and CD57 immunostainings for discrimination between endocrine ductal carcinoma in situ and intraductal papilloma. (20518901)
2010
11
Intraductal papilloma arising from sublingual minor salivary gland: case report and immunohistochemical study. (19426904)
2009
12
"Signet-ring" cell invasive lobular carcinoma of the breast - accidental finding associated with intraductal papilloma: a case report. (19200374)
2009
13
Excision is indicated for intraductal papilloma of the breast diagnosed on core needle biopsy. (19402174)
2009
14
Ultrasound-guided vacuum-assisted breast biopsy system for diagnosis and minimally invasive excision of intraductal papilloma without nipple discharge. (19777298)
2009
15
Intraoral intraductal papilloma: a case report. (18201187)
2008
16
Complicated solitary intraductal papilloma of the breast. (17971167)
2008
17
Intraductal papilloma of the parotid gland in a child. (17598121)
2007
18
Infarcted intraductal papilloma of the breast: cytologic features with stage of infarction. (16604546)
2006
19
Solitary intraductal papilloma of the breast--a diagnostic dilemma and the role of conferencing between surgeons and cytologist. (17183864)
2006
20
Cytokeratins in papillary lesions of the breast: is there a role in distinguishing intraductal papilloma from papillary ductal carcinoma in situ? (15832086)
2005
21
Myoepithelial cell staining patterns of papillary breast lesions: from intraductal papillomas to invasive papillary carcinomas. (15762278)
2005
22
Intraductal papilloma of the breast: F-18 FDG PET demonstration. (15965323)
2005
23
Intraductal papilloma arising from Stensen's duct. (16343407)
2005
24
Intraductal papilloma with "comedo-like" necrosis, a diagnostic pitfall. (15494933)
2004
25
Solitary intraductal papilloma of the male breast: diagnostic value of galactography. (12846873)
2003
26
Magnetic resonance imaging of intraductal papilloma of the breast. (14599539)
2003
27
Study of CD44v6 protein expression in intraductal papilloma and its malignant transformation of breast]. (12452061)
2002
28
Case of the Month. Giant multiple intraductal papilloma of the breast: a case report and review of the literature. (11320612)
2001
29
Diagnosis of ductal carcinoma in situ (DCIS) and intraductal papilloma using fluorescence in situ hybridization (FISH) analysis. (11114860)
2000
30
Solitary intraductal papilloma: findings at MR imaging and MR galactography. (9888758)
1999
31
Intraductal papilloma of the salivary gland. A report of two cases with diagnosis by fine needle aspiration biopsy. (10578993)
1999
32
Breast imaging case of the day. Benign intraductal papilloma with focal atypical papillomatous hyperplasia. (9599399)
1998
33
A case of intraductal papilloma of breast in advanced age. (10209933)
1998
34
Intraductal papilloma associated with metaplastic carcinoma of the breast. (9416498)
1997
35
Intraductal papilloma as a cause of a parotid duct cyst. A case report. (8730370)
1996
36
Intraductal papilloma of the male breast--case report. (7959989)
1994
37
Different incidence of loss of heterozygosity on chromosome 16q between intraductal papilloma and intracystic papillary carcinoma of the breast. (7961109)
1994
38
Intraductal papilloma and papillomatosis. (1345385)
1992-1993
39
Spontaneous infarction of an intraductal papilloma of the breast: cytological presentation on fine needle aspiration. (1486182)
1992
40
The risk of breast cancer subsequent to histologic diagnosis of benign intraductal papilloma follow-up study of 339 cases. (2017798)
1991
41
The operative management of intraductal papilloma of the breast. (2342242)
1990
42
Giant intraductal papilloma of the breast: a case report. (2984474)
1985
43
Electron microscopy of intraductal papilloma of the breast. Ultrastructural comparison of papillary carcinoma with normal mammary large duct. (6301211)
1983
44
The value of ductogalactography in the diagnosis of intraductal papilloma. (6665877)
1983
45
Intraductal papilloma arising in supernumerary vulvar breast tissue. (7360456)
1980
46
Solitary intraductal papilloma of the minor salivary glands. (1057130)
1975
47
Giant form of intraductal papilloma of the breast. (5552896)
1971
48
Cander risk in intraductal papilloma and papillomatosis. (4302515)
1968
49
Intraductal papilloma of the breast. (13772356)
1961
50
Surgical management of benign intraductal papilloma of the breast. (14911043)
1952

Variations for Intraductal Papilloma

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Expression for genes affiliated with Intraductal Papilloma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Intraductal Papilloma

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Pathways for genes affiliated with Intraductal Papilloma

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51PathCards, 31KEGG, 52PharmGKB, 39NCBI BioSystems Database, 56Reactome, 61Thomson Reuters
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Pathways related to Intraductal Papilloma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
L-serine degradation39
pentose phosphate pathway (oxidative branch)39
formaldehyde oxidation II (glutathione-dependent)39
9.7IDH1, IDH2
29.7IDH1, IDH2
3
Show member pathways
TCA cycle39
pyruvate decarboxylation to acetyl CoA39
NAD phosphorylation and dephosphorylation39
TCA Cycle39
conversion of glucose to acetyl CoA and entry into the TCA cycle39
9.7IDH1, IDH2
4
Show member pathways
glutathione-mediated detoxification I39
glutathione redox reactions I39
glutathione redox reactions II39
4-hydroxy-2-nonenal detoxification39
Glutathione metabolism61
Glutathione metabolism39
9.7IDH1, IDH2

Compounds for genes affiliated with Intraductal Papilloma

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25HMDB, 12DrugBank, 46Novoseek, 30IUPHAR, 62Tocris Bioscience
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Compounds related to Intraductal Papilloma according to GeneCards/GeneDecks:

(show all 16)
idCompoundScoreTop Affiliating Genes
1Oxalosuccinic acid2510.0IDH1, IDH2
2Isocitric acid25 1211.0IDH1, IDH2
3isocitrate469.9IDH2, IDH1
4Oxoglutaric acid259.9IDH1, IDH2
5carbon dioxide46 2510.6IDH1, IDH2
6hematoxylin469.5TP63, MYH11
7hpaii469.4PRKG1, CD44
8glucose 6-phosphate46 2510.2PRKG1, IDH1
9p003469.2TP63, CD44
10paraffin469.1TP63, MYH11, CD44
11progesterone46 30 62 25 1213.0CD44, MYH11, TP63
12thymidine46 259.9CD44, PRKG1, TP63
13testosterone46 62 25 1211.7TP63, PRKG1, CD44
14nitric oxide46 25 1210.5CD44, PRKG1, MYH11
15vegf468.3CD44, PRKG1, MYH11, TP63
16estrogen468.3CD44, PRKG1, MYH11, TP63

GO Terms for genes affiliated with Intraductal Papilloma

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17Gene Ontology
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Biological processes related to Intraductal Papilloma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glyoxylate cycleGO:0060979.7IDH1, IDH2
2tricarboxylic acid cycleGO:0060999.7IDH1, IDH2
3isocitrate metabolic processGO:0061029.6IDH1, IDH2
42-oxoglutarate metabolic processGO:0061039.4IDH1, IDH2

Molecular functions related to Intraductal Papilloma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1NAD bindingGO:0512879.7IDH1, IDH2
2isocitrate dehydrogenase (NADP+) activityGO:0044509.4IDH1, IDH2

Products for genes affiliated with Intraductal Papilloma

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Sources for Intraductal Papilloma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet