MCID: INT016
MIFTS: 38

Intraductal Papilloma malady

Summaries for Intraductal Papilloma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Intraductal papillomas of the breast are benign lesions with an incidence of approximately 2-3% in... more...

MalaCards: Intraductal Papilloma, also known as papilloma, intraductal, is related to papilloma and papillary carcinoma. An important gene associated with Intraductal Papilloma is IDH1 (isocitrate dehydrogenase 1 (NADP+), soluble), and among its related pathways are Glutathione metabolism and Citric acid cycle (TCA cycle). The compounds Isocitric Acid and isocitrate have been mentioned in the context of this disorder. Affiliated tissues include breast, salivary gland and lymph node, and related mouse phenotypes are muscle and renal/urinary system.

Aliases & Classifications for Intraductal Papilloma

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
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Aliases & Descriptions:

intraductal papilloma 8 10
papilloma, intraductal 60
papilloma intraductal 44
ductal papilloma 8


External Ids:

Disease Ontology8 DOID:1627
NCIt39 C3785
SNOMED-CT56 5244003
MeSH34 D018300

Related Diseases for Intraductal Papilloma

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Intraductal Papilloma:



Diseases related to intraductal papilloma

Clinical Features for Intraductal Papilloma

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Drugs & Therapeutics for Intraductal Papilloma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Intraductal Papilloma

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Anatomical Context for Intraductal Papilloma

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32MalaCards
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MalaCards organs/tissues related to Intraductal Papilloma:

32
Breast, Salivary gland, Lymph node

Animal Models for Intraductal Papilloma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Intraductal Papilloma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.6TP63, CD44, MYH11, PRKG1
2MP:00053678.5TP63, CD44, MYH11, PRKG1
3MP:00053818.3PRKG1, MYH11, CD44, TP63

Publications for Intraductal Papilloma

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50PubMed
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Articles related to Intraductal Papilloma:

(show top 50)    (show all 92)
idTitleAuthorsYear
1
Mammotome biopsy in diagnosing and treatment of intraductal papilloma of the breast. (23640929)
2013
2
Intraductal papilloma: atypical presentation. (23762648)
2013
3
Concurrent fibroadenoma and intraductal papilloma - A recurring complex lesion in a premenarcheal girl. (23218483)
2013
4
Combined evaluation of CK5/6, ER, p63, and MUC3 for distinguishing breast intraductal papilloma from ductal carcinoma in situ. (22612506)
2012
5
Surgical excision of intraductal breast papilloma diagnosed on core biopsy. (22510128)
2012
6
Is CD56 a specific and reliable neuroendocrine marker for discriminating between endocrine/neuroendocrine ductal carcinoma in situ and intraductal papilloma of the breast? (21166944)
2011
7
Intraductal papilloma of the breast in association with preoncogenic gene of breast cancer. (23569749)
2011
8
Enlarging unilateral breast mass in an adolescent male: an unusual presentation of intraductal papilloma. (21616226)
2011
9
Intraductal papilloma of ectopic breast tissue in axillary lymph node of a patient with a previous intraductal papilloma of ipsilateral breast: a case report and review of the literature. (20222992)
2010
10
Evaluation of CD56 and CD57 immunostainings for discrimination between endocrine ductal carcinoma in situ and intraductal papilloma. (20518901)
2010
11
Intraductal papilloma arising from sublingual minor salivary gland: case report and immunohistochemical study. (19426904)
2009
12
A potential diagnostic pitfall in aspiration cytology in intraductal papilloma of the parotid gland. (19697742)
2009
13
Complicated solitary intraductal papilloma of the breast. (17971167)
2008
14
Benign epithelial proliferations in axillary lymph nodes with ipsilateral breast in situ ductal carcinoma and intraductal papilloma of the breast. (18439159)
2008
15
Myoepithelial cells in solid variant of intraductal papillary carcinoma of the breast: a potential diagnostic pitfall and a proposal of an immunohistochemical panel in the differential diagnosis with intraductal papilloma with usual ductal hyperplasia. (17377808)
2007
16
Infarcted intraductal papilloma of the breast: cytologic features with stage of infarction. (16604546)
2006
17
Solitary intraductal papilloma of the breast--a diagnostic dilemma and the role of conferencing between surgeons and cytologist. (17183864)
2006
18
Cytokeratins in papillary lesions of the breast: is there a role in distinguishing intraductal papilloma from papillary ductal carcinoma in situ? (15832086)
2005
19
Intraductal papilloma of the breast: F-18 FDG PET demonstration. (15965323)
2005
20
Intraductal papilloma arising from Stensen's duct. (16343407)
2005
21
Intraductal papilloma in the parotid duct. (12030582)
2002
22
Intraductal papilloma of the parotid gland in a child. (12121243)
2002
23
Case of the Month. Giant multiple intraductal papilloma of the breast: a case report and review of the literature. (11320612)
2001
24
Intraductal papilloma of the parotid gland in a child. (11555769)
2001
25
Intraductal papilloma of the submandibular gland. (10962690)
2000
26
Fine needle aspiration cytology of an intraductal papilloma originating in a sublingual gland. A case report. (10349381)
1999
27
CD44s as a surrogate marker for distinguishing intraductal papilloma from papillary carcinoma of the breast. (10690183)
1999
28
Breast imaging case of the day. Benign intraductal papilloma with focal atypical papillomatous hyperplasia. (9599399)
1998
29
A case of intraductal papilloma of breast in advanced age. (10209933)
1998
30
Intraductal papilloma associated with metaplastic carcinoma of the breast. (9416498)
1997
31
Intraductal papilloma as a cause of a parotid duct cyst. A case report. (8730370)
1996
32
Intraductal papilloma of the male breast--case report. (7959989)
1994
33
Intraductal papilloma of the male breast: an ultrastructural and immunohistochemical study. (7855934)
1994
34
Papillary adenocarcinoma possibly arising from an intraductal papilloma of the parotid gland. (8177584)
1994
35
Intraductal papilloma of the anterior lingual salivary gland. Case report and immunohistochemical study. (7686571)
1993
36
Intraductal papilloma and papillomatosis. (1345385)
1992-1993
37
Spontaneous infarction of an intraductal papilloma of the breast: cytological presentation on fine needle aspiration. (1486182)
1992
38
The risk of breast cancer subsequent to histologic diagnosis of benign intraductal papilloma follow-up study of 339 cases. (2017798)
1991
39
The operative management of intraductal papilloma of the breast. (2342242)
1990
40
Giant intraductal papilloma of the breast: a case report. (2984474)
1985
41
Electron microscopy of intraductal papilloma of the breast. Ultrastructural comparison of papillary carcinoma with normal mammary large duct. (6301211)
1983
42
Infarction of intraductal papilloma associated with hyperprolactinemia. (6892762)
1980
43
The management of bleeding intraductal papilloma of the breast. (4352938)
1973
44
Giant form of intraductal papilloma of the breast. (5552896)
1971
45
Cander risk in intraductal papilloma and papillomatosis. (4302515)
1968
46
Intraductal papilloma of the breast. (5214021)
1965
47
Benign intraductal papilloma of the male breast: case report. (13888699)
1962
48
Intraductal papilloma of the hard palate: case report of an underscribed lesion of a minor salivary gland. (13145191)
1954
49
The papillary neoplasms of the breast. I. Benign intraductal papilloma. (14800254)
1951
50
Intraductal papilloma of the breast. (18862421)
1948

Genetic Variations for Intraductal Papilloma

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Expression for genes affiliated with Intraductal Papilloma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Intraductal Papilloma

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Pathways for genes affiliated with Intraductal Papilloma

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29KEGG, 37NCBI BioSystems Database, 53Reactome
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Pathways related to Intraductal Papilloma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Glutathione metabolism
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9.8IDH2, IDH1
2
Hide members
9.8IDH2, IDH1
39.8IDH2, IDH1

Compounds for genes affiliated with Intraductal Papilloma

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11DrugBank, 24HMDB, 44Novoseek
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Compounds related to Intraductal Papilloma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1Isocitric Acid11 2410.9IDH2, IDH1
2isocitrate449.8IDH1, IDH2
3hematoxylin449.6TP63, MYH11
4hpaii449.5CD44, PRKG1
5paraffin448.8MYH11, CD44, TP63
6vegf448.6TP63, CD44, MYH11, PRKG1
7estrogen448.5TP63, CD44, MYH11, PRKG1

GO Terms for genes affiliated with Intraductal Papilloma

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16Gene Ontology
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Cellular components related to Intraductal Papilloma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:0058297.9TP63, MYH11, PRKG1, DOCK4, IDH1

Biological processes related to Intraductal Papilloma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glyoxylate cycleGO:0060979.8IDH2, IDH1
2tricarboxylic acid cycleGO:0060999.8IDH2, IDH1
3isocitrate metabolic processGO:0061029.7IDH2, IDH1
42-oxoglutarate metabolic processGO:0061039.5IDH2, IDH1

Molecular functions related to Intraductal Papilloma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1NAD bindingGO:0512879.8IDH2, IDH1
2isocitrate dehydrogenase (NADP+) activityGO:0044509.5IDH2, IDH1

Products for genes affiliated with Intraductal Papilloma

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Sources for Intraductal Papilloma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet