MCID: INT016
MIFTS: 35

Intraductal Papilloma

Categories: Cancer diseases

Aliases & Classifications for Intraductal Papilloma

MalaCards integrated aliases for Intraductal Papilloma:

Name: Intraductal Papilloma 12 14
Papilloma, Intraductal 41 69
Papilloma Intraductal 51
Ductal Papilloma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1627
MeSH 41 D018300
NCIt 46 C3785
SNOMED-CT 64 5244003
UMLS 69 C0206713

Summaries for Intraductal Papilloma

MalaCards based summary : Intraductal Papilloma, also known as papilloma, intraductal, is related to breast disease and breast duct papilloma. An important gene associated with Intraductal Papilloma is TP63 (Tumor Protein P63), and among its related pathways/superpathways are Citrate cycle (TCA cycle) and Peroxisome. Affiliated tissues include breast, salivary gland and lymph node, and related phenotypes are cardiovascular system and digestive/alimentary

Wikipedia : 72 Intraductal papillomas of the breast are benign lesions with an incidence of approximately 2-3% in... more...

Related Diseases for Intraductal Papilloma

Diseases related to Intraductal Papilloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)
# Related Disease Score Top Affiliating Genes
1 breast disease 11.2
2 breast duct papilloma 11.1
3 papilloma 10.8
4 ductal carcinoma in situ 10.2
5 papillary carcinoma 10.2
6 interval angle-closure glaucoma 10.2 IDH1 IDH2
7 adult oligodendroglioma 10.2 IDH1 IDH2
8 enchondroma 10.2 IDH1 IDH2
9 intracranial chondrosarcoma 10.1 IDH1 IDH2
10 glioma susceptibility 1 10.1 IDH1 IDH2
11 anaplastic oligodendroglioma 10.1 IDH1 IDH2
12 cytogenetically normal acute myeloid leukemia 10.1 IDH1 IDH2
13 chondroblastic osteosarcoma 10.1 IDH1 IDH2
14 spinal cord astrocytoma 10.1 CD44 IDH1
15 multiple enchondromatosis, maffucci type 10.1 IDH1 IDH2
16 spindle cell hemangioma 10.1 IDH1 IDH2
17 periosteal chondrosarcoma 10.1 IDH1 IDH2
18 adult astrocytic tumour 10.1 IDH1 IDH2
19 fibrillary astrocytoma 10.1 IDH1 IDH2
20 undifferentiated pleomorphic sarcoma 10.1 IDH1 IDH2
21 drug-induced mental disorder 10.1 IDH1 IDH2
22 drug psychosis 10.1 IDH1 IDH2
23 diffuse infiltrative lymphocytosis syndrome 10.1 IDH1 IDH2
24 2-hydroxyglutaric aciduria 10.1 IDH1 IDH2
25 polymorphous low-grade adenocarcinoma 10.1 MYH11 TP63
26 breast papillary carcinoma 10.0 IDH1 IDH2
27 d-2-hydroxyglutaric aciduria 1 10.0 IDH1 IDH2
28 enchondromatosis, multiple, ollier type 10.0 IDH1 IDH2
29 bile duct adenocarcinoma 10.0 IDH1 IDH2
30 cell type cancer 9.9 CD44 IDH1
31 intrahepatic cholangiocarcinoma 9.9 IDH1 IDH2
32 brain cancer 9.8 CD44 IDH1 IDH2
33 aging 9.8
34 hyperprolactinemia 9.8
35 benign breast phyllodes tumor 9.8
36 adenocarcinoma 9.8
37 papillary adenocarcinoma 9.8
38 hidradenoma 9.8
39 oligodendroglioma 9.8 IDH1 IDH2
40 chondrosarcoma 9.6 IDH1 IDH2
41 aneurysm 9.6 MYH11 PRKG1
42 leukemia, acute myeloid 9.6 IDH1 IDH2 MYH11
43 aortic aneurysm 9.5 MYH11 PRKG1

Graphical network of the top 20 diseases related to Intraductal Papilloma:



Diseases related to Intraductal Papilloma

Symptoms & Phenotypes for Intraductal Papilloma

MGI Mouse Phenotypes related to Intraductal Papilloma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.85 TP63 CD44 DOCK4 IDH2 MYH11 PRKG1
2 digestive/alimentary MP:0005381 9.62 TP63 CD44 MYH11 PRKG1
3 muscle MP:0005369 9.56 TP63 CD44 MYH11 PRKG1
4 neoplasm MP:0002006 9.46 TP63 CD44 DOCK4 IDH2
5 renal/urinary system MP:0005367 9.26 TP63 CD44 MYH11 PRKG1
6 respiratory system MP:0005388 8.92 TP63 CD44 IDH1 MYH11

Drugs & Therapeutics for Intraductal Papilloma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Feasibility and Therapeutic Efficacy of Ductoscopic Papilloma Extraction in Patients With Pathologic Nipple Discharge Recruiting NCT01901562 Phase 1, Phase 2
2 The Incidence of Adjacent Synchronous Ipsilateral Infiltrating Carcinoma and/or DCIS in Patients Diagnosed With Intraductal Papilloma Without Atypia or Flat Epithelial Atypia by Core Needle Biopsy Recruiting NCT02489617

Search NIH Clinical Center for Intraductal Papilloma

Cochrane evidence based reviews: papilloma, intraductal

Genetic Tests for Intraductal Papilloma

Anatomical Context for Intraductal Papilloma

MalaCards organs/tissues related to Intraductal Papilloma:

38
Breast, Salivary Gland, Lymph Node

Publications for Intraductal Papilloma

Articles related to Intraductal Papilloma:

(show top 50) (show all 107)
# Title Authors Year
1
Challenging Atypical Breast Lesions Including Flat Epithelial Atypia, Radial Scar, and Intraductal Papilloma. ( 28766216 )
2017
2
Intraductal papilloma of the breast in an 11-year-old male patient: a case report. ( 28353086 )
2017
3
The Management Strategy of Benign Solitary Intraductal Papilloma on Breast Core Biopsy. ( 28438672 )
2017
4
Molecular alterations in lesions of anogenital mammary-like glands and their mammary counterparts including hidradenoma papilliferum, intraductal papilloma, fibroadenoma and phyllodes tumor. ( 28648934 )
2017
5
Primary Osteosarcoma of the Breast Arising in an Intraductal Papilloma. ( 28713607 )
2017
6
Intraductal Papilloma with Benign Pathology on Breast Core Biopsy: To Excise or Not? ( 26960929 )
2016
7
Intraductal papilloma of the male breast. ( 26860828 )
2016
8
Floor of Mouth Mass. Intraductal papilloma. ( 26583524 )
2016
9
Apocrine Metaplasia in Intraductal Papilloma with Foci of DCIS: A Friend or Foe? ( 27499780 )
2016
10
Exuberant squamous metaplasia in an intraductal papilloma of breast. ( 25583984 )
2015
11
The significance of combined CK5/6 and p63 immunohistochemistry in predicting the risks of subsequent carcinoma development in intraductal papilloma of the breast. ( 25572436 )
2015
12
Immunocytochemical analysis of p63 and 34I^E12 in fine needle aspiration cytology specimens for breast lesions: a potentially useful discriminatory marker between intraductal papilloma and ductal carcinoma inA situ. ( 25810244 )
2015
13
A prolapsed intraductal papilloma: a case report. ( 28058341 )
2015
14
A Case of Intraductal Papilloma of the Breast With High 18F-FDG Uptake on PET/CT. ( 26164173 )
2015
15
Collagen Type XI Alpha 1 Expression in Intraductal Papillomas Predicts Malignant Recurrence. ( 26448946 )
2015
16
MRI characteristics of intraductal papilloma. ( 24696194 )
2014
17
Intraductal papilloma in an axillary lymph node of a patient with human immunodeficiency virus: a case report and review of the literature. ( 24884898 )
2014
18
Diagnosis of a Nonpalpable Intraductal Papilloma without Radiological Abnormality by Nipple Discharge Smear Examination: A Case Report. ( 24737934 )
2014
19
Intraductal papilloma: atypical presentation. ( 23762648 )
2013
20
Concurrent fibroadenoma and intraductal papilloma - A recurring complex lesion in a premenarcheal girl. ( 23218483 )
2013
21
Mammotome biopsy in diagnosing and treatment of intraductal papilloma of the breast. ( 23640929 )
2013
22
Intraductal papilloma of the breast: A case report. ( 23396758 )
2012
23
Combined evaluation of CK5/6, ER, p63, and MUC3 for distinguishing breast intraductal papilloma from ductal carcinoma in situ. ( 22612506 )
2012
24
MRI features of intraductal papilloma of the breast: sheep in wolf's clothing? ( 21498361 )
2011
25
Glucose transporter expression of intraductal papilloma of the breast detected by fluorodeoxyglucose positron emission tomography. ( 21519997 )
2011
26
Intraductal papilloma of the breast in association with preoncogenic gene of breast cancer. ( 23569749 )
2011
27
Enlarging unilateral breast mass in an adolescent male: an unusual presentation of intraductal papilloma. ( 21616226 )
2011
28
Is CD56 a specific and reliable neuroendocrine marker for discriminating between endocrine/neuroendocrine ductal carcinoma in situ and intraductal papilloma of the breast? ( 21166944 )
2011
29
Evaluation of CD56 and CD57 immunostainings for discrimination between endocrine ductal carcinoma in situ and intraductal papilloma. ( 20518901 )
2010
30
Intraductal papilloma of ectopic breast tissue in axillary lymph node of a patient with a previous intraductal papilloma of ipsilateral breast: a case report and review of the literature. ( 20222992 )
2010
31
Intraductal papilloma arising from sublingual minor salivary gland: case report and immunohistochemical study. ( 19426904 )
2009
32
Carcinoma in a solitary intraductal papilloma of the breast. ( 19261097 )
2009
33
Ultrasound-guided vacuum-assisted breast biopsy system for diagnosis and minimally invasive excision of intraductal papilloma without nipple discharge. ( 19777298 )
2009
34
External herniation of a subareolar intraductal papilloma: a rare, yet beneficial, complication of conventional ductography. ( 19913136 )
2009
35
Excision is indicated for intraductal papilloma of the breast diagnosed on core needle biopsy. ( 19402174 )
2009
36
A potential diagnostic pitfall in aspiration cytology in intraductal papilloma of the parotid gland. ( 19697742 )
2009
37
"Signet-ring" cell invasive lobular carcinoma of the breast - accidental finding associated with intraductal papilloma: a case report. ( 19200374 )
2009
38
Intraoral intraductal papilloma: a case report. ( 18201187 )
2008
39
Intraductal carcinoma arising in intraductal papilloma in an axillary lymph node: review of the literature and proposed theories of evolution. ( 19061295 )
2008
40
Benign epithelial proliferations in axillary lymph nodes with ipsilateral breast in situ ductal carcinoma and intraductal papilloma of the breast. ( 18439159 )
2008
41
Complicated solitary intraductal papilloma of the breast. ( 17971167 )
2008
42
Myoepithelial cells in solid variant of intraductal papillary carcinoma of the breast: a potential diagnostic pitfall and a proposal of an immunohistochemical panel in the differential diagnosis with intraductal papilloma with usual ductal hyperplasia. ( 17377808 )
2007
43
Intraductal papilloma of the parotid gland in a child. ( 17598121 )
2007
44
Infarcted intraductal papilloma of the breast: cytologic features with stage of infarction. ( 16604546 )
2006
45
Intraductal papilloma: features on MR ductography using a microscopic coil. ( 16357375 )
2006
46
Solitary intraductal papilloma of the breast--a diagnostic dilemma and the role of conferencing between surgeons and cytologist. ( 17183864 )
2006
47
Intraductal papilloma in a reconstructed breast: mammographic and sonographic appearance with pathologic correlation. ( 16448815 )
2006
48
Myoepithelial cell staining patterns of papillary breast lesions: from intraductal papillomas to invasive papillary carcinomas. ( 15762278 )
2005
49
Intraductal papilloma of the breast: F-18 FDG PET demonstration. ( 15965323 )
2005
50
Intraductal papilloma arising from Stensen's duct. ( 16343407 )
2005

Variations for Intraductal Papilloma

Expression for Intraductal Papilloma

Search GEO for disease gene expression data for Intraductal Papilloma.

Pathways for Intraductal Papilloma

Pathways related to Intraductal Papilloma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.17 IDH1 IDH2
2 10.87 IDH1 IDH2
3
Show member pathways
9.74 IDH1 IDH2

GO Terms for Intraductal Papilloma

Cellular components related to Intraductal Papilloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi apparatus GO:0005794 9.26 CD44 DOCK4 PRKG1 TP63
2 cytosol GO:0005829 9.17 CD44 DOCK4 IDH1 IDH2 MYH11 PRKG1

Biological processes related to Intraductal Papilloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tricarboxylic acid cycle GO:0006099 9.26 IDH1 IDH2
2 2-oxoglutarate metabolic process GO:0006103 9.16 IDH1 IDH2
3 isocitrate metabolic process GO:0006102 8.96 IDH1 IDH2
4 glyoxylate cycle GO:0006097 8.62 IDH1 IDH2

Molecular functions related to Intraductal Papilloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NAD binding GO:0051287 9.26 IDH1 IDH2
2 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 9.16 IDH1 IDH2
3 isocitrate dehydrogenase activity GO:0004448 8.96 IDH1 IDH2
4 isocitrate dehydrogenase (NADP+) activity GO:0004450 8.62 IDH1 IDH2

Sources for Intraductal Papilloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
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29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
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35 IUPHAR
36 KEGG
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41 MeSH
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43 MGI
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47 NDF-RT
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54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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