MCID: INT079
MIFTS: 43

Intrahepatic Cholangiocarcinoma malady

Liver diseases, Cancer diseases categories

Summaries for Intrahepatic Cholangiocarcinoma

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42NIH Rare Diseases, 32MalaCards
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NIH Rare Diseases:42 Intrahepatic cholangiocarcinoma is a cancer that develops in the cells within the bile ducts; both inside and outside the liver. the terms cholangiocarinoma and bile duct cancer are often used to refer to the same condition. this condition occurs slightly more often in males than females and usually affects people who are between 50-70 years old. signs and symptoms of intrahepatic cholangiocarcinoma include jaundice, abdominal pain, fever, weight loss, weakness and itching. treatment options may include surgery to remove the bile duct and parts of the liver, chemotherapy and radiation. last updated: 4/1/2014

MalaCards: Intrahepatic Cholangiocarcinoma, also known as intrahepatic bile duct carcinoma, is related to cholangiocarcinoma and hepatitis. An important gene associated with Intrahepatic Cholangiocarcinoma is DMRTC1 (DMRT-like family C1). The compound ethidium bromide have been mentioned in the context of this disorder. Affiliated tissues include liver, lymph node and colon.

Aliases & Classifications for Intrahepatic Cholangiocarcinoma

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8Disease Ontology, 42NIH Rare Diseases, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Liver diseases


Aliases & Descriptions:

intrahepatic cholangiocarcinoma 8 42 60
intrahepatic bile duct carcinoma 8
peripheral cholangiocarcinoma 8
bile duct cancer 42


External Ids:

Disease Ontology8 DOID:4928
MeSH34 C535533
SNOMED-CT56 109842005
NCIt39 C35417

Related Diseases for Intrahepatic Cholangiocarcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Intrahepatic Cholangiocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 64)
idRelated DiseaseScoreTop Affiliating Genes
1cholangiocarcinoma32.2MAGEA3
2hepatitis11.0
3hepatocellular carcinoma10.8
4hepatitis b10.7
5hepatitis a10.7
6bile duct carcinoma10.6
7mucinous intrahepatic cholangiocarcinoma10.6
8hepatitis c10.6
9sarcomatous intrahepatic cholangiocarcinoma10.5
10viral hepatitis10.5
11adenocarcinoma10.4
12liver disease10.4
13signet ring cell intrahepatic cholangiocarcinoma10.3
14choledochal cyst10.3
15liver cirrhosis10.3
16bone carcinoma10.3
17bile duct adenocarcinoma10.3
18sclerosing cholangitis10.2
19adenoma10.2
20cholangitis10.2
21pancreatitis10.2
22common bile duct neoplasm10.1
23obstructive jaundice10.1
24liver carcinoma in situ10.1
25situs inversus10.1
26mucinous adenocarcinoma10.1
27bile duct mucinous adenocarcinoma10.1
28lymph node cancer10.1
29lynch syndrome10.1
30pancreatic cancer10.1
31hellp syndrome10.1
32non-hodgkin lymphoma10.1
33primary biliary cirrhosis10.1
34lymphoepithelioma-like carcinoma10.1
35liver inflammatory pseudotumor10.1
36hemochromatosis10.1
37intrahepatic biliary papillomatosis10.1
38gastrointestinal stromal tumor10.1
39portal vein thrombosis10.1
40autoimmune hepatitis10.1
41ulcerative colitis10.1
42nijmegen breakage syndrome10.1
43alcoholic hepatitis10.1
44clonorchiasis10.1
45bile duct disease10.1
46biliary papillomatosis10.1
47colon cancer10.1
48cystadenocarcinoma10.1
49gallbladder adenocarcinoma10.1
50gallbladder cancer10.1

Graphical network of the top 20 diseases related to Intrahepatic Cholangiocarcinoma:



Diseases related to intrahepatic cholangiocarcinoma

Clinical Features for Intrahepatic Cholangiocarcinoma

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Drugs & Therapeutics for Intrahepatic Cholangiocarcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Intrahepatic Cholangiocarcinoma

Drug clinical trials:

Search ClinicalTrials for Intrahepatic Cholangiocarcinoma

Search NIH Clinical Center for Intrahepatic Cholangiocarcinoma

Search CenterWatch for Intrahepatic Cholangiocarcinoma

Genetic Tests for Intrahepatic Cholangiocarcinoma

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Anatomical Context for Intrahepatic Cholangiocarcinoma

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32MalaCards
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MalaCards organs/tissues related to Intrahepatic Cholangiocarcinoma:

32
Liver, Lymph node, Colon, T cells, Skeletal muscle, Brain, Endothelial, Small intestine, Testis, Thyroid, Testes, Lung, Kidney, Ovary, Fetal liver

Animal Models for Intrahepatic Cholangiocarcinoma or affiliated genes

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Publications for Intrahepatic Cholangiocarcinoma

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50PubMed
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Articles related to Intrahepatic Cholangiocarcinoma:

(show top 50)    (show all 565)
idTitleAuthorsYear
1
Clinical significances of cancer stem cells markers in patients with intrahepatic cholangiocarcinoma who underwent hepatectomy. (23645762)
2013
2
Notching up on the cellular origins of intrahepatic cholangiocarcinoma. (23390051)
2013
3
Decreased roundabout 1 expression promotes development of intrahepatic cholangiocarcinoma. (23953227)
2013
4
MiR-376c down-regulation accelerates EGF-dependent migration by targeting GRB2 in the HuCCT1 human intrahepatic cholangiocarcinoma cell line. (23922722)
2013
5
Prognosis analysis of sarcomatous intrahepatic cholangiocarcinoma from a review of the literature. (23824556)
2013
6
Multidisciplinary approaches to intrahepatic cholangiocarcinoma. (23963845)
2013
7
High serum CA19-9 levels are associated with an increased risk of cholangiocarcinoma in patients with intrahepatic duct stones: a case-control study. (23760942)
2013
8
Identification of prognostic factors and the impact of palliative resection on survival of patients with stage IV hepatolithiasis-associated intrahepatic cholangiocarcinoma. (24310342)
2013
9
Cell lineage tracing reveals a biliary origin of intrahepatic cholangiocarcinoma. (24310400)
2013
10
Synchronous development of intrahepatic cholangiocarcinoma and hepatocellular carcinoma in different sites of the liver with chronic B-viral hepatitis: two case reports. (24313990)
2013
11
Predictive factors of recurrence for patients with intrahepatic cholangiocarcinoma after hepatectomy. (22369746)
2012
12
L1 cell adhesion molecule and epidermal growth factor receptor activation confer cisplatin resistance in intrahepatic cholangiocarcinoma cells. (22088438)
2012
13
Fatty acid-binding protein 5 promotes cell proliferation and invasion in human intrahepatic cholangiocarcinoma. (22825302)
2012
14
Inflammatory pseudotumors mimicking intrahepatic cholangiocarcinoma of the liver; IgG4-positivity and its clinical significance. (21894477)
2012
15
Clinical impact of lymph node dissection in surgery for peripheral-type intrahepatic cholangiocarcinoma. (22124809)
2012
16
Contrast-enhanced ultrasound of intrahepatic cholangiocarcinoma: correlation with pathological examination. (22374276)
2012
17
Ubiquitin-specific protease 14 expression associated with intrahepatic cholangiocarcinoma cell differentiation. (21627382)
2011
18
Retrospective analysis of prognostic factors after liver transplantation for intrahepatic cholangiocarcinoma in China: a single-center experience. (21937390)
2011
19
Staging of peripheral-type intrahepatic cholangiocarcinoma: appraisal of the new TNM classification and its modifications. (21879422)
2011
20
Viral hepatitis is associated with intrahepatic cholangiocarcinoma with cholangiolar differentiation and N-cadherin expression. (21423153)
2011
21
Small intestinal metastasis from intrahepatic cholangiocarcinoma: report of a case. (21626338)
2011
22
Prognostic significance of NQO1 expression in intrahepatic cholangiocarcinoma. (21577322)
2011
23
Radiofrequency ablation for the treatment of primary intrahepatic cholangiocarcinoma. (21257864)
2011
24
Clinicopathologic significance of slug expression in human intrahepatic cholangiocarcinoma. (20503457)
2010
25
Intrahepatic cholangiocarcinoma. (20202772)
2010
26
Aberrant expression of vimentin correlates with dedifferentiation and poor prognosis in patients with intrahepatic cholangiocarcinoma. (20651380)
2010
27
Intrahepatic cholangiocarcinoma and hepatocellular carcinoma: differential diagnosis with contrast-enhanced ultrasound. (19760416)
2010
28
Decreased intratumoral arteries reflect portal tract destruction and aggressive characteristics in intrahepatic cholangiocarcinoma. (19309397)
2009
29
N-cadherin serves as diagnostic biomarker in intrahepatic and perihilar cholangiocarcinomas. (18622386)
2009
30
Prognostic value of MUC4 for mass-forming intrahepatic cholangiocarcinoma after hepatectomy. (19082442)
2009
31
Significance of repeated resection for recurrent intrahepatic cholangiocarcinoma. (19453018)
2009
32
Clinicopathological analysis of colorectal cancer liver metastasis and intrahepatic cholangiocarcinoma: are they just apples and oranges? (18329969)
2008
33
Indications for surgical treatment of intrahepatic cholangiocarcinoma with lymph node metastases. (18670844)
2008
34
Transcatheter arterial chemoembolization or chemoinfusion for unresectable intrahepatic cholangiocarcinoma: clinical efficacy and factors influencing outcomes. (18704990)
2008
35
Difference in biological characteristics and sensitivity to chemotherapy and radiotherapy between intrahepatic and extrahepatic cholangiocarcinoma cells in vitro. (18437912)
2008
36
A case of an alpha-fetoprotein-producing intrahepatic cholangiocarcinoma suggests probable cancer stem cell origin. (17405896)
2007
37
Double primary liver cancer (intrahepatic cholangiocarcinoma and hepatocellular carcinoma) in a patient with hepatitis C virus-related cirrhosis. (17384916)
2007
38
Transarterial chemoembolization (TACE) for inoperable intrahepatic cholangiocarcinoma. (17508242)
2007
39
Response to cetuximab and gemcitabine-oxaliplatin in an advanced case of intrahepatic cholangiocarcinoma. (16817335)
2006
40
Delayed-phase dynamic CT enhancement as a prognostic factor for mass-forming intrahepatic cholangiocarcinoma. (16304089)
2006
41
Liver transplantation for double primary hepatic cancer-hepatocellular carcinoma and intrahepatic cholangiocarcinoma. (16969301)
2006
42
Well differentiated intrahepatic cholangiocarcinoma in the setting of biliary papillomatosis: a case report and review of the literature. (16341314)
2005
43
Promoter methylation and loss of coding exons of the fragile histidine triad (FHIT) gene in intrahepatic cholangiocarcinomas. (16343073)
2005
44
Intrahepatic cholangiocarcinoma masked as fever of unknown origin. (15036199)
2004
45
Intrahepatic cholangiocarcinoma: indication for transplantation. (14598146)
2003
46
Diagnosis and surgical treatment of peripheral intrahepatic cholangiocarcinoma]. (11758193)
2001
47
Fine-needle aspiration cytologic diagnosis of intrahepatic biliary papillomatosis (intraductal papillary tumor): report of three cases and comparative study with cholangiocarcinoma. (10790236)
2000
48
Extended right hepatic lobectomy with resection of inferior vena cava and portal vein for intrahepatic cholangiocarcinoma. (11180893)
2000
49
Cytokeratin profile relates to histological subtypes and intrahepatic location of intrahepatic cholangiocarcinoma and primary sites of metastatic adenocarcinoma of liver. (10931219)
2000
50
Increased midkine expression in intrahepatic cholangiocarcinoma: immunohistochemical and in situ hybridization analyses. (10902971)
2000

Genetic Variations for Intrahepatic Cholangiocarcinoma

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Expression for genes affiliated with Intrahepatic Cholangiocarcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Intrahepatic Cholangiocarcinoma

Search GEO for disease gene expression data for Intrahepatic Cholangiocarcinoma.

Pathways for genes affiliated with Intrahepatic Cholangiocarcinoma

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Compounds for genes affiliated with Intrahepatic Cholangiocarcinoma

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44Novoseek
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Compounds related to Intrahepatic Cholangiocarcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1ethidium bromide4410.7MAGEA1, MAGEA3

GO Terms for genes affiliated with Intrahepatic Cholangiocarcinoma

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Products for genes affiliated with Intrahepatic Cholangiocarcinoma

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Sources for Intrahepatic Cholangiocarcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet