MCID: INT079
MIFTS: 43

Intrahepatic Cholangiocarcinoma malady

Liver diseases, Cancer diseases categories

Summaries for Intrahepatic Cholangiocarcinoma

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42NIH Rare Diseases, 32MalaCards
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NIH Rare Diseases:42 Intrahepatic cholangiocarcinoma is a cancer that develops in the cells within the bile ducts; both inside and outside the liver. the terms cholangiocarinoma and bile duct cancer are often used to refer to the same condition. this condition occurs slightly more often in males than females and usually affects people who are between 50-70 years old. signs and symptoms of intrahepatic cholangiocarcinoma include jaundice, abdominal pain, fever, weight loss, weakness and itching. treatment options may include surgery to remove the bile duct and parts of the liver, chemotherapy and radiation. last updated: 4/1/2014

MalaCards: Intrahepatic Cholangiocarcinoma, also known as intrahepatic bile duct carcinoma, is related to cholangiocarcinoma and hepatitis. An important gene associated with Intrahepatic Cholangiocarcinoma is DMRTC1 (DMRT-like family C1). The compound ethidium bromide have been mentioned in the context of this disorder. Affiliated tissues include liver, lymph node and colon.

Aliases & Classifications for Intrahepatic Cholangiocarcinoma

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8Disease Ontology, 42NIH Rare Diseases, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Liver diseases


Aliases & Descriptions:

intrahepatic cholangiocarcinoma 8 42 60
intrahepatic bile duct carcinoma 8
peripheral cholangiocarcinoma 8
bile duct cancer 42


External Ids:

Disease Ontology8 DOID:4928
MeSH34 C535533
SNOMED-CT56 109842005
NCIt39 C35417

Related Diseases for Intrahepatic Cholangiocarcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Intrahepatic Cholangiocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 64)
idRelated DiseaseScoreTop Affiliating Genes
1cholangiocarcinoma32.2MAGEA3
2hepatitis11.0
3hepatocellular carcinoma10.8
4hepatitis b10.7
5hepatitis a10.7
6bile duct carcinoma10.6
7mucinous intrahepatic cholangiocarcinoma10.6
8hepatitis c10.6
9sarcomatous intrahepatic cholangiocarcinoma10.5
10viral hepatitis10.5
11adenocarcinoma10.4
12liver disease10.4
13signet ring cell intrahepatic cholangiocarcinoma10.3
14choledochal cyst10.3
15liver cirrhosis10.3
16bone carcinoma10.3
17bile duct adenocarcinoma10.3
18sclerosing cholangitis10.2
19adenoma10.2
20cholangitis10.2
21pancreatitis10.2
22common bile duct neoplasm10.1
23obstructive jaundice10.1
24liver carcinoma in situ10.1
25situs inversus10.1
26mucinous adenocarcinoma10.1
27bile duct mucinous adenocarcinoma10.1
28lymph node cancer10.1
29lynch syndrome10.1
30pancreatic cancer10.1
31hellp syndrome10.1
32non-hodgkin lymphoma10.1
33primary biliary cirrhosis10.1
34lymphoepithelioma-like carcinoma10.1
35liver inflammatory pseudotumor10.1
36hemochromatosis10.1
37intrahepatic biliary papillomatosis10.1
38gastrointestinal stromal tumor10.1
39portal vein thrombosis10.1
40autoimmune hepatitis10.1
41ulcerative colitis10.1
42nijmegen breakage syndrome10.1
43alcoholic hepatitis10.1
44clonorchiasis10.1
45bile duct disease10.1
46biliary papillomatosis10.1
47colon cancer10.1
48cystadenocarcinoma10.1
49gallbladder adenocarcinoma10.1
50gallbladder cancer10.1

Graphical network of the top 20 diseases related to Intrahepatic Cholangiocarcinoma:



Diseases related to intrahepatic cholangiocarcinoma

Clinical Features for Intrahepatic Cholangiocarcinoma

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Drugs & Therapeutics for Intrahepatic Cholangiocarcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Intrahepatic Cholangiocarcinoma

Drug clinical trials:

Search ClinicalTrials for Intrahepatic Cholangiocarcinoma

Search NIH Clinical Center for Intrahepatic Cholangiocarcinoma

Search CenterWatch for Intrahepatic Cholangiocarcinoma

Genetic Tests for Intrahepatic Cholangiocarcinoma

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Anatomical Context for Intrahepatic Cholangiocarcinoma

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32MalaCards
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MalaCards organs/tissues related to Intrahepatic Cholangiocarcinoma:

32
Liver, Lymph node, Colon, T cells, Brain, Skeletal muscle, Endothelial, Testes, Testis, Ovary, Thyroid, Lung, Kidney, Small intestine, Fetal liver

Animal Models for Intrahepatic Cholangiocarcinoma or affiliated genes

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Publications for Intrahepatic Cholangiocarcinoma

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50PubMed
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Articles related to Intrahepatic Cholangiocarcinoma:

(show top 50)    (show all 565)
idTitleAuthorsYear
1
Cocarcinogenic effects of intrahepatic bile Acid accumulation in cholangiocarcinoma development. (24255171)
2014
2
Influence of Surgical Margins on Outcome in Patients With Intrahepatic Cholangiocarcinoma: A Multicenter Study by the AFC-IHCC-2009 Study Group. (23979290)
2014
3
Morphological subclassification of intrahepatic cholangiocarcinoma: etiological, clinicopathological, and molecular features. (24406866)
2014
4
Hepatobiliary resection with concomitant resection of the inferior vena cava for advanced intrahepatic cholangiocarcinoma: report of a case. (22961194)
2013
5
BRAF V600E-specific immunohistochemistry reveals low mutation rates in biliary tract cancer and restriction to intrahepatic cholangiocarcinoma. (24309328)
2013
6
Prognosis of the intrahepatic cholangiocarcinoma after resection: hepatitis B virus infection and adjuvant chemotherapy are favorable prognosis factors. (24139471)
2013
7
Routine lymph node dissection may be not suitable for all intrahepatic cholangiocarcinoma patients: Results of a monocentric series. (24379635)
2013
8
Adjuvant gemcitabine therapy improves survival in a locally induced, R0-resectable model of metastatic intrahepatic cholangiocarcinoma. (23686746)
2013
9
Intrahepatic cholangiocarcinoma with sarcomatous change producing granulocyte-colony stimulating factor. (23692426)
2013
10
Expression of microRNAs, miR-21, miR-31, miR-122, miR-145, miR-146a, miR-200c, miR-221, miR-222, and miR-223 in patients with hepatocellular carcinoma or intrahepatic cholangiocarcinoma and its prognostic significance. (22213236)
2013
11
Integrative molecular analysis of intrahepatic cholangiocarcinoma reveals 2 classes that have different outcomes. (23295441)
2013
12
miR-204 inhibits epithelial to mesenchymal transition by targeting slug in intrahepatic cholangiocarcinoma cells. (24280681)
2013
13
The expression of phospho-AKT1 and phospho-MTOR is associated with a favorable prognosis independent of PTEN expression in intrahepatic cholangiocarcinomas. (21874010)
2012
14
Role of thymidylate synthase and dihydropyrimidine dehydrogenase mRNA in intrahepatic cholangiocarcinoma. (22143355)
2012
15
Hepatitis viruses infection and risk of intrahepatic cholangiocarcinoma: evidence from a meta-analysis. (22799744)
2012
16
Postoperative adjuvant transcatheter arterial chemoembolisation improves survival of intrahepatic cholangiocarcinoma patients with poor prognostic factors: results of a large monocentric series. (22417704)
2012
17
An oestrogen receptor I^-selective agonist exerts anti-neoplastic effects in experimental intrahepatic cholangiocarcinoma. (21782536)
2012
18
Radiofrequency ablation in the management of unresectable intrahepatic cholangiocarcinoma. (22525022)
2012
19
Combined hepatocellular-cholangiocarcinoma had poor outcomes after hepatectomy regardless of Allen and Lisa class or the predominance of intrahepatic cholangiocarcinoma cells within the tumor. (22113592)
2012
20
A case of intrahepatic cholangiocarcinoma with marked mucus production. (22128317)
2011
21
A case of clonorchiasis with focal intrahepatic duct dilatation mimicking an intrahepatic cholangiocarcinoma. (22741114)
2011
22
Hypoxia inducible factor expression in intrahepatic cholangiocarcinoma. (21940327)
2011
23
Ribonucleotide reductase M1 expression in intrahepatic cholangiocarcinoma. (21940346)
2011
24
Radiofrequency ablation of intrahepatic cholangiocarcinoma: preliminary experience. (20411389)
2010
25
Clinical presentation and management of intrahepatic cholangiocarcinoma. (20202770)
2010
26
Overexpression of CD151 as an adverse marker for intrahepatic cholangiocarcinoma patients. (20715158)
2010
27
Clinicopathological prognostic factors after hepatectomy for patients with mass-forming type intrahepatic cholangiocarcinoma: relevance of the lymphatic invasion index. (20135355)
2010
28
L1 cell adhesion molecule is a novel therapeutic target in intrahepatic cholangiocarcinoma. (20501614)
2010
29
OEM-TACE: a new therapeutic approach in unresectable intrahepatic cholangiocarcinoma. (19727937)
2009
30
Overlapping signature genes between hepatocellular carcinoma and intrahepatic cholangiocarcinoma. (19826380)
2009
31
Viral hepatitis-associated intrahepatic cholangiocarcinoma shares common disease processes with hepatocellular carcinoma. (19436294)
2009
32
Expression of stem cell factor and its receptor c-Kit during the development of intrahepatic cholangiocarcinoma. (19255573)
2009
33
Retrospective analysis of histopathologic prognostic factors after hepatectomy for intrahepatic cholangiocarcinoma. (19556914)
2009
34
Prognosis of perihilar cholangiocarcinoma: hilar bile duct cancer versus intrahepatic cholangiocarcinoma involving the hepatic hilus. (18057991)
2008
35
Hepatobiliary resection with inferior vena cava resection and reconstruction using an autologous patch graft for intrahepatic cholangiocarcinoma. (18043938)
2008
36
Fluorine-18 fluorodeoxyglucose positron emission tomography predicts lymph node metastasis, P-glycoprotein expression, and recurrence after resection in mass-forming intrahepatic cholangiocarcinoma. (18549893)
2008
37
Intrahepatic cholangiocarcinoma mimicking hepatic inflammatory pseudotumor. (17458614)
2007
38
Proposal of progression model for intrahepatic cholangiocarcinoma: clinicopathologic differences between hilar type and peripheral type. (17592273)
2007
39
Elevated expression of cyclooxygenase-2 is a negative prognostic factor for overall survival in intrahepatic cholangiocarcinoma. (17165088)
2007
40
Mutations in bile salt export pump (ABCB11) in two children with progressive familial intrahepatic cholestasis and cholangiocarcinoma. (17452236)
2007
41
Intrahepatic cholangiocarcinoma arising in cirrhotic liver frequently expressed p63-positive basal/stem-cell phenotype. (16377099)
2006
42
Analysis of p53 mutations for a mutational signature in human intrahepatic cholangiocarcinoma. (16596244)
2006
43
Possible regulation of migration of intrahepatic cholangiocarcinoma cells by interaction of CXCR4 expressed in carcinoma cells with tumor necrosis factor-alpha and stromal-derived factor-1 released in stroma. (16565491)
2006
44
A long-term survivor of intrahepatic cholangiocarcinoma with paraaortic lymph node metastasis. (16741622)
2006
45
Characterization of intrahepatic cholangiocarcinoma of the intraductal growth-type and its precursor lesions. (16116640)
2005
46
Intrahepatic cholangiocarcinoma escapes from growth inhibitory effect of transforming growth factor-beta1 by overexpression of cyclin D1. (15696189)
2005
47
Expression of MAGE-A3 in intrahepatic cholangiocarcinoma and its precursor lesions. (14989741)
2004
48
Prognostic factors in node-negative intrahepatic cholangiocarcinoma with special reference to angiogenesis. (15041507)
2004
49
c-erbB-2 and c-Met expression relates to cholangiocarcinogenesis and progression of intrahepatic cholangiocarcinoma. (11895493)
2002
50
Intrahepatic cholangiocarcinoma arising in congenital hepatic fibrosis: report of an autopsy case. (9566842)
1998

Genetic Variations for Intrahepatic Cholangiocarcinoma

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Expression for genes affiliated with Intrahepatic Cholangiocarcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Intrahepatic Cholangiocarcinoma

Search GEO for disease gene expression data for Intrahepatic Cholangiocarcinoma.

Pathways for genes affiliated with Intrahepatic Cholangiocarcinoma

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Compounds for genes affiliated with Intrahepatic Cholangiocarcinoma

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44Novoseek
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Compounds related to Intrahepatic Cholangiocarcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1ethidium bromide4410.7MAGEA1, MAGEA3

GO Terms for genes affiliated with Intrahepatic Cholangiocarcinoma

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Products for genes affiliated with Intrahepatic Cholangiocarcinoma

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Sources for Intrahepatic Cholangiocarcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet