MCID: INT001
MIFTS: 55

Intrahepatic Cholestasis malady

Genetic diseases, Rare diseases, Liver diseases, Reproductive diseases, Respiratory diseases, Metabolic diseases, Nephrological diseases categories

Summaries for Intrahepatic Cholestasis

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Genetics Home Reference:21 Intrahepatic cholestasis of pregnancy is a liver disorder that occurs in pregnant women. Cholestasis is a condition that impairs the release of a digestive fluid called bile from liver cells. As a result, bile builds up in the liver, impairing liver function. Because the problems with bile release occur within the liver (intrahepatic), the condition is described as intrahepatic cholestasis. Intrahepatic cholestasis of pregnancy usually becomes apparent in the third trimester of pregnancy. Bile flow returns to normal after delivery of the baby, and the signs and symptoms of the condition disappear. However, they can return during later pregnancies.

MalaCards based summary: Intrahepatic Cholestasis, also known as intrahepatic cholestasis of pregnancy, is related to cholestasis, benign recurrent intrahepatic and hepatitis. An important gene associated with Intrahepatic Cholestasis is ATP8B1 (ATPase, aminophospholipid transporter, class I, type 8B, member 1), and among its related pathways are ABC-family proteins mediated transport and Nuclear Receptor transcription pathway. The compounds hepaplastin and wort have been mentioned in the context of this disorder. Affiliated tissues include liver, placenta and testes, and related mouse phenotypes are growth/size/body and liver/biliary system.

Aliases & Classifications for Intrahepatic Cholestasis

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Sources:
9Disease Ontology, 41NIH Rare Diseases, 20GeneTests, 21Genetics Home Reference, 11DISEASES, 43Novoseek, 47Orphanet, 60UMLS, 55SNOMED-CT, 33MeSH, 38NCIt, 34MESH via Orphanet, 26ICD10 via Orphanet
See all sources

Intrahepatic Cholestasis, Aliases & Descriptions:

Name: Intrahepatic Cholestasis 9 11 60
Intrahepatic Cholestasis of Pregnancy 9 41 21 47
Recurrent Intrahepatic Cholestasis of Pregnancy 41 21 47
Familial Intrahepatic Cholestasis of Pregnancy 41 20 60
Chronic Pneumonitis of Infancy 41 47
Pregnancy-Related Cholestasis 21 47
Cpi 41 47
Familial Recurrent Intrahepatic Cholestasis of Pregnancy 41
 
Cholestasis, Intrahepatic of Pregnancy 41
Gravidic Intrahepatic Cholestasis 47
Pregnancy Related Cholestasis 41
Cholestasis Intrahepatic 43
Cholestasis of Pregnancy 60
Obstetric Cholestasis 21
Ricp 41
Icp 41


Classifications:



Characteristics (Orphanet epidemiological data):

47
intrahepatic cholestasis of pregnancy:
Inheritance: Multigenic/multifactorial,Not applicable; Age of onset: Adult
chronic pneumonitis of infancy:
Inheritance: Not applicable; Age of onset: Infancy,Neonatal


External Ids:

Disease Ontology9 DOID:1852
MeSH33 D002780
NCIt38 C84400
SNOMED-CT55 4637005
Orphanet47 69665, 91359
MESH via Orphanet34 C535932
ICD10 via Orphanet26 O26.6, J84.0

Related Diseases for Intrahepatic Cholestasis

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Diseases in the Intrahepatic Cholestasis family:

Cholestasis, Benign Recurrent Intrahepatic, 2 Cholestasis, Benign Recurrent Intrahepatic
Cholestasis, Progressive Familial Intrahepatic 2 Cholestasis, Progressive Familial Intrahepatic 3
Cholestasis, Progressive Familial Intrahepatic 4 Cholestasis, Progressive Familial Intrahepatic 1
Atp8b1-Related Intrahepatic Cholestasis Abcb11-Related Intrahepatic Cholestasis

Diseases related to Intrahepatic Cholestasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 135)
idRelated DiseaseScoreTop Affiliating Genes
1cholestasis, benign recurrent intrahepatic31.9ATP8B1, ABCB11
2hepatitis31.6SLC17A5, F2, GPT
3cholestasis, progressive familial intrahepatic 131.5ABCB11, NR1H4, ABCB4, ATP8B1
4cholestasis, progressive familial intrahepatic 331.3ABCB4, ABCB11, ATP8B1
5low gamma-gt familial intrahepatic cholestasis31.3ABCB11, ATP8B1
6cholestasis, progressive familial intrahepatic 231.3ABCB4, ABCB11, ATP8B1
7liver disease31.0NR1H4, F2, ABCB4, ABCB11, ATP8B1
8citrullinemia, adult-onset type ii30.9SLC25A13
9portal hypertension30.8SLC17A5, F2, GPT
10cholelithiasis30.8GPT, ABCB4, ABCB11
11choledocholithiasis30.8SLC17A5, GPT
12viral hepatitis30.8GPT, SLC17A5, F2
13biliary atresia30.8GPT, ATP8B1, NR1H4, SLC25A13
14cholestasis30.7SLC25A13, CIRH1A, ABCC2, ABCB11, ABCB4, F2
15cholangitis30.6ABCB4, SLC17A5, GPT
16acute liver failure30.6GPT, F2, SLC17A5
17autoimmune hepatitis30.6F2, GPT, SLC17A5
18hepatitis b30.6F2, GPT, SLC17A5
19hepatitis c30.5ABCC2, SLC17A5, F2, GPT
20alagille syndrome30.5ABCB4, ATP8B1
21hellp syndrome30.5SLC17A5, GPT
22obesity29.9AHSG, SLC17A5, NR1I3, GPT, NR1H4
23breast cancer29.2ABCB4, NR1H4, NR1I3, NR1I2, ABCC2, ABCB11
24hepatocellular carcinoma28.4ABCB4, ABCC2, GPT, AHSG, NR1I2, SLC17A5
25citrullinemia, type ii, neonatal-onset10.7
26amyloidosis10.6
27hepatitis a10.5F2
28cholestasis, benign recurrent intrahepatic, 210.5
29pancreatitis10.5
30hyperbilirubinemia, rotor type, digenic10.4ABCC2
31hydrocephalus10.4
32hepatitis e10.4GPT
33neonatal intrahepatic cholestasis due to citrin deficiency10.4
34pyridoxine deficiency10.4SLC17A5, GPT
35placental abruption10.4F2
36neonatal hemochromatosis10.4SLC25A13, SLC17A5
37cholestasis, intrahepatic, of pregnancy, 110.4
38eclampsia10.4
39sickle cell disease10.4
40atp8b1-related intrahepatic cholestasis10.4
41abcb11-related intrahepatic cholestasis10.4
42hepatic amyloidosis with intrahepatic cholestasis10.4
43factor vii deficiency10.3F2
44neonatal jaundice10.3NR1I3
45cerebritis10.3
46obstructive jaundice10.3SLC17A5, GPT
47alcoholic hepatitis10.3F2, SLC17A5, GPT
48aneurysm10.3
49galactosemia10.3SLC17A5, GPT, F2
50hepatitis c virus10.3

Graphical network of the top 20 diseases related to Intrahepatic Cholestasis:



Diseases related to intrahepatic cholestasis

Symptoms for Intrahepatic Cholestasis

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Drugs & Therapeutics for Intrahepatic Cholestasis

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Drug clinical trials:

Search ClinicalTrials for Intrahepatic Cholestasis

Search NIH Clinical Center for Intrahepatic Cholestasis

Genetic Tests for Intrahepatic Cholestasis

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Genetic tests related to Intrahepatic Cholestasis:

id Genetic test Affiliating Genes
1 Cholestasis, Familial Intrahepatic, of Pregnancy20 ABCB4

Anatomical Context for Intrahepatic Cholestasis

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MalaCards organs/tissues related to Intrahepatic Cholestasis:

31
Liver, Placenta, Testes, Bone, Heart, Smooth muscle, Small intestine, Colon, Breast, Appendix, Neutrophil

Animal Models for Intrahepatic Cholestasis or affiliated genes

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MGI Mouse Phenotypes related to Intrahepatic Cholestasis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053788.0F2, ABCB11, ATP8B1, AHSG, NR1I3, NR1H4
2MP:00053707.0SLCO1B3, NR1H4, NR1I3, NR1I2, ATP8B1, ABCC2
3MP:00053765.9HLA-G, NR1H4, NR1I3, NR1I2, AHSG, ATP8B1

Publications for Intrahepatic Cholestasis

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Articles related to Intrahepatic Cholestasis:

(show top 50)    (show all 692)
idTitleAuthorsYear
1
Acute fatty liver of pregnancy with hypoglycaemia, diabetes insipidus and pancreatitis, preceded by intrahepatic cholestasis of pregnancy. (25878236)
2015
2
Intrahepatic cholestasis of pregnancy: maternal and fetal outcomes associated with elevated bile acid levels. (25818669)
2015
3
Placental gene-expression profiles of intrahepatic cholestasis of pregnancy reveal involvement of multiple molecular pathways in blood vessel formation and inflammation. (25001852)
2014
4
Effect of taurocholic acid on fetoplacental arterial pressures in a dual perfusion placental cotyledon model: a novel approach to intrahepatic cholestasis of pregnancy. (25098026)
2014
5
Two Cases of Progressive Familial Intrahepatic Cholestasis Type 2 Presenting with Severe Coagulopathy without Jaundice. (24991443)
2014
6
Intrahepatic Cholestasis of Pregnancy: mRNAs for LIPF and ELOVL4 Genes Are Not Detectable in Circulating Maternal Plasma. (25059952)
2014
7
Fetal complications due to intrahepatic cholestasis of pregnancy. (25153210)
2014
8
Ursodeoxycholic acid in the treatment of intrahepatic cholestasis of pregnancy: a randomized controlled trial. (23978872)
2013
9
Clinical grading of intrahepatic cholestasis pregnancy. (24362672)
2013
10
Primary bile acids as potential biomarkers for the clinical grading of intrahepatic cholestasis of pregnancy. (23562588)
2013
11
Heptral (ademetionine) in patients with intrahepatic cholestasis in chronic liver disease due to non-alcoholic liver disease: results of a multicentre observational study in India. (25154164)
2013
12
Study on the regulation of cell adhesion molecule expression and function in placenta from women with intrahepatic cholestasis of pregnancy. (23810461)
2013
13
Orthotopic liver transplantation in a pediatric patient with progressive intrahepatic cholestasis: a coordinated perioperative subspecialty approach. (21603342)
2011
14
Clinical features and genotype-phenotype correlations in children with progressive familial intrahepatic cholestasis type 3 related to ABCB4 mutations. (21119540)
2011
15
SLC25A13 gene analysis in neonates with intrahepatic cholestasis caused by citrin deficiency]. (21507300)
2011
16
Acute intrahepatic cholestasis accompanied with Chlamydophila pneumoniae infection. (21424938)
2011
17
Pancreatic adenocarcinoma in type 2 progressive familial intrahepatic cholestasis. (20226067)
2010
18
Neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD) in three Malay children. (20614727)
2010
19
Progressive familial intrahepatic cholestasis. (21134824)
2010
20
Combined functional variants of hepatobiliary transporters and FXR aggravate intrahepatic cholestasis of pregnancy. (19490418)
2009
21
Liver transplantation for progressive familial intrahepatic cholestasis: the evolving role of genotyping. (19479788)
2009
22
SLC25A13 gene mutations in Chinese infants with intrahepatic cholestasis and abnormal blood amino acids]. (18578996)
2008
23
Hepatobiliary phospholipid transporter ABCB4, MDR3 gene variants in a large cohort of Italian women with intrahepatic cholestasis of pregnancy. (18083082)
2008
24
SLC25A13 gene mutation analysis in a pedigree of neonatal intrahepatic cholestasis caused by citrin deficiency]. (17880783)
2007
25
Partial internal biliary diversion through a cholecystojejunocolonic anastomosis--a novel surgical approach for patients with progressive familial intrahepatic cholestasis: a preliminary report. (17706492)
2007
26
Clinical and experimental study on wuling pill in treating gestation period intrahepatic cholestasis]. (16548349)
2006
27
Necrotizing hepatitis and intrahepatic cholestasis associated to Cryptococcus sp. and Pneumocystis carinii. (17151583)
2006
28
Association between polymorphisms of CYP17 and CYP3A4 genes and intrahepatic cholestasis of pregnancy in Chengdu]. (16909599)
2006
29
Potential role of trans-inhibition of the bile salt export pump by progesterone metabolites in the etiopathogenesis of intrahepatic cholestasis of pregnancy. (16458994)
2006
30
A difficult and complicated case study: neonatal intrahepatic cholestasis caused by citrin deficiency]. (16613706)
2006
31
Progressive familial intrahepatic cholestasis with normal GGT level appearing with lichenification and enlargement of hands and feet. (16363353)
2005
32
Laparoscopic partial external biliary diversion procedure in progressive familial intrahepatic cholestasis: a new approach. (16235123)
2005
33
Intrahepatic cholestasis of pregnancy: Relationships between bile acid levels and fetal complication rates. (15368452)
2004
34
Benign recurrent intrahepatic cholestasis progressing to progressive familial intrahepatic cholestasis: low GGT cholestasis is a clinical continuum. (11867191)
2002
35
Intrahepatic cholestasis after liver transplantation. (14607733)
2002
36
Intrahepatic cholestasis of pregnancy: review of the literature. (11773831)
2002
37
Ursodeoxycholic acid for the treatment of intrahepatic cholestasis of pregnancy. (11392594)
2001
38
HLA-A33/B44/DR6 is highly related to intrahepatic cholestasis induced by tiopronin. (10877223)
2000
39
Oral guar gum, a gel-forming dietary fiber relieves pruritus in intrahepatic cholestasis of pregnancy. (10746839)
2000
40
Intrahepatic cholestasis of pregnancy has no effect on maternal serum second trimester alpha-fetoprotein and hCG. (10929953)
2000
41
Treatment of progressive familial intrahepatic cholestasis: liver transplantation or partial external biliary diversion. (10487283)
1999
42
The ultrasonographic 'triangular cord' coupled with gallbladder images in the diagnostic prediction of biliary atresia from infantile intrahepatic cholestasis. (10591576)
1999
43
Intrahepatic cholestasis related to vanishing bile duct syndrome in Hodgkin's disease. (9144127)
1997
44
Intractable cough and abnormal pulmonary function in benign recurrent intrahepatic cholestasis. (8855752)
1996
45
Intrahepatic cholestasis without hepatitis induced by amoxycillin/clavulanic acid. (8877644)
1996
46
Genome screening by searching for shared segments: mapping a gene for benign recurrent intrahepatic cholestasis. (7894490)
1994
47
Efficacy of ursodeoxycholic acid in preventing cholestatic episodes in a patient with benign recurrent intrahepatic cholestasis. (1639361)
1992
48
Intrahepatic cholestasis of pregnancy and acute fatty liver of pregnancy. An unusual but favorable association? (2001812)
1991
49
Familial recurrent intrahepatic cholestasis of pregnancy: a genetic study providing evidence for transmission of a sex-limited, dominant trait. (6852450)
1983
50
Bile acid metabolism in benign recurrent intrahepatic cholestasis. Comparative studies on the icteric and anicteric phases of a single case. (437403)
1979

Variations for Intrahepatic Cholestasis

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Clinvar genetic disease variations for Intrahepatic Cholestasis:

6
id Gene Variation Type Significance SNP ID Assembly Location
1ABCB4NM_018849.2(ABCB4): c.2869C> T (p.Arg957Ter)single nucleotide variantPathogenicrs121918440GRCh37Chr 7, 87041264: 87041264
2ABCB4NM_018849.2(ABCB4): c.1712delT (p.Val571Aspfs)deletionPathogenicrs387906527GRCh37Chr 7, 87069002: 87069002
3ABCB4NM_018849.2(ABCB4): c.1637C> A (p.Ala546Asp)single nucleotide variantPathogenicrs121918441GRCh37Chr 7, 87069077: 87069077
4ABCB4NM_018849.2(ABCB4): c.959C> T (p.Ser320Phe)single nucleotide variantPathogenicrs72552778GRCh37Chr 7, 87076396: 87076396
5ABCB4NM_018849.2(ABCB4): c.1328_1329delAGinsCAA (p.Gln443Profs)indelPathogenicrs387906528GRCh37Chr 7, 87072662: 87072663
6ABCB4NM_018849.2(ABCB4): c.430C> T (p.Arg144Ter)single nucleotide variantPathogenicrs72552780GRCh37Chr 7, 87082366: 87082366
7ABCB4NM_018849.2(ABCB4): c.1769G> A (p.Arg590Gln)single nucleotide variantPathogenicrs45575636GRCh37Chr 7, 87060844: 87060844
8ATP8B1NM_005603.4(ATP8B1): c.208G> A (p.Asp70Asn)single nucleotide variantPathogenicrs34719006GRCh37Chr 18, 55373793: 55373793
9NM_005603.4(ATP8B1): c.2599C> T (p.Arg867Cys)single nucleotide variantPathogenicrs121909103GRCh37Chr 18, 55328514: 55328514

Expression for genes affiliated with Intrahepatic Cholestasis

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Search GEO for disease gene expression data for Intrahepatic Cholestasis.

Pathways for genes affiliated with Intrahepatic Cholestasis

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Pathways related to Intrahepatic Cholestasis according to GeneCards Suite gene sharing:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7ABCB11, ABCB4, ABCC2
2
Show member pathways
Nuclear Receptors36
9.3NR1H4, NR1I3, NR1I2
39.2ABCC2, NR1I2, NR1I3
4
Show member pathways
9.0NR1I2, SLCO1B3, ABCC2
5
Show member pathways
8.9ABCC2, ABCB4, ABCB11, SLCO1A2
6
Show member pathways
8.8SLCO1A2, SLCO1B3, ABCB11
7
Show member pathways
8.7ABCC2, SLCO1A2, SLCO1B3
88.7ABCC2, NR1I3, NR1H4, ABCB11, NR1I2
98.5ABCB11, ABCB4, ABCC2, NR1I2, NR1I3, NR1H4
10
Show member pathways
8.5ABCB11, ABCC2, SLCO1A2, SLCO1B3
11
Show member pathways
8.2ATP8B1, SLCO1A2, SLC17A5, SLCO1B3, ABCC2
128.0SLCO1B3, ABCB4, ABCB11, NR1H4, SLCO1A2, ABCC2

Compounds for genes affiliated with Intrahepatic Cholestasis

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Compounds related to Intrahepatic Cholestasis according to GeneCards Suite gene sharing:

(show top 50)    (show all 220)
idCompoundScoreTop Affiliating Genes
1hepaplastin4310.0SLC17A5, F2, GPT
2wort439.7ABCB11, ABCC2, NR1I2
3lamivudine43 49 1211.6SLC17A5, GPT, ABCC2, F2
4glycocholate439.6ABCB11, GPT, ABCC2, ABCB4, SLC17A5
5androstane439.3NR1I2, NR1I3, NR1H4, ABCC2
6urea43 24 1211.2HLA-G, SLC25A13, ABCC2, GPT, SLC17A5
73a,6b,7a,12a-Tetrahydroxy-5b-cholanoic acid249.1SLCO1A2, ABCB11, SLCO1B3
8Allocholic acid249.1SLCO1B3, SLCO1A2, ABCB11
9Allochenodeoxycholic acid249.1ABCB11, SLCO1A2, SLCO1B3
107b,12a-Dihydroxycholanoic acid249.1ABCB11, SLCO1A2, SLCO1B3
11phenytoin43 49 28 1212.1SLC17A5, NR1I3, NR1I2, ABCC2, ABCB11
123b,7a,12a-Trihydroxy-5b-cholanoic acid249.0ABCB11, SLCO1A2, SLCO1B3
13Isohyodeoxycholic acid249.0ABCB11, SLCO1A2, SLCO1B3
14tacrolimus43 49 1211.0ABCB11, SLC17A5, GPT, ABCB4, NR1I2, ABCC2
15Isodeoxycholic acid249.0ABCB11, SLCO1A2, SLCO1B3
16Isoallolithocholic acid249.0ABCB11, SLCO1A2, SLCO1B3
173a,4b,7a-Trihydroxy-5b-cholanoic acid249.0SLCO1A2, SLCO1B3, ABCB11
18deoxycholic acid43 28 24 1211.9NR1H4, SLCO1A2, ABCB11, SLCO1B3
1912a-Hydroxy-3-oxocholadienic acid248.9ABCB11, SLCO1A2, SLCO1B3
20ritonavir43 49 1210.9ABCB11, ABCC2, NR1I2, SLCO1A2
2112-Ketodeoxycholic acid248.9ABCB11, SLCO1A2, SLCO1B3
22ketoconazole43 28 24 1211.9ABCC2, ABCB11, NR1I2, SLCO1A2
23Taurocholic acid24 129.8ABCB11, SLCO1B3, SLCO1A2, ABCC2
24bromosulfophthalein438.8SLCO1B3, SLCO1A2, GPT, ABCC2
251,3,7,12-Tetrahydroxycholan-24-oic acid248.8ABCB11, SLCO1A2, SLCO1B3
263b,4b,7a,12a-Tetrahydroxy-5b-cholanoic acid248.8ABCB11, SLCO1A2, SLCO1B3
27phenobarbital43 28 49 1211.8NR1I3, SLC17A5, GPT, ABCC2, ABCB11, NR1I2
28simvastatin43 49 59 28 24 1213.8ABCC2, GPT, SLCO1A2, SLC17A5, F2
29acetaminophen43 2 49 24 1212.7NR1I2, GPT, F2, NR1I3, SLC17A5, ABCC2
30verapamil43 28 49 24 1212.7SLC17A5, SLCO1A2, GPT, ABCC2, ABCB11, ABCB4
313a,6a,7b-Trihydroxy-5b-cholanoic acid248.7SLCO1B3, ABCB11, SLCO1A2
32pravastatin43 49 28 24 1212.6ABCC2, SLCO1A2, SLCO1B3, ABCB11, GPT
33atorvastatin43 49 28 24 1212.5SLCO1B3, ABCC2, SLCO1A2, SLC17A5, GPT
343b,7a,12a-Trihydroxy-5a-Cholanoic acid248.5ABCB11, SLCO1A2, SLCO1B3
35paclitaxel43 49 1210.4ABCB4, ABCB11, NR1I3, NR1I2, ABCC2, SLCO1B3
36rifampin49 129.4ABCB11, ABCC2, SLCO1A2, SLCO1B3, NR1I2
37rosuvastatin43 49 28 1211.3SLCO1A2, SLCO1B3, ABCC2, GPT, ABCB11, SLC17A5
38taurocholate438.2NR1H4, ABCB4, ABCB11, ABCC2, ATP8B1, SLCO1B3
39estrogen438.1AHSG, F2, ABCB11, ABCC2, NR1I3, NR1H4
40cholic acid43 28 24 1211.1NR1I2, SLCO1B3, SLCO1A2, NR1H4, ABCB11, ABCC2
41lithocholic acid43 28 2410.0NR1I3, ABCB11, SLCO1B3, SLCO1A2, NR1I2, NR1H4
42digoxin43 59 49 24 1211.8SLCO1B3, SLC17A5, SLCO1A2, NR1I2, ABCC2, ABCB11
43lipid437.7NR1I2, NR1I3, NR1H4, SLC17A5, HLA-G, ATP8B1
44dexamethasone43 49 28 1210.7ABCB11, ABCB4, ABCC2, NR1I3, HLA-G, NR1I2
45cyclosporin a43 28 599.7F2, SLCO1B3, SLC17A5, NR1I3, NR1I2, GPT
46rifampicin43 28 599.4SLCO1B3, SLC17A5, ABCB11, ABCC2, GPT, NR1I2
47cholesterol43 28 24 1210.3SLC17A5, NR1H4, NR1I3, NR1I2, GPT, HLA-G
48chenodeoxycholic acid43 28 24 1210.2NR1H4, SLCO1A2, NR1I2, GPT, ABCC2, ABCB4
49methotrexate49 43 129.2NR1I2, GPT, HLA-G, ABCC2, ABCB4, F2
50ursodeoxycholic acid43 24 129.1SLCO1B3, SLC17A5, SLCO1A2, NR1H4, NR1I2, GPT

GO Terms for genes affiliated with Intrahepatic Cholestasis

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Cellular components related to Intrahepatic Cholestasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intercellular canaliculusGO:00465819.7ABCB4, ABCB11, ABCC2
2apical plasma membraneGO:00163249.2ATP8B1, ABCB4, ABCB11, ABCC2
3integral component of plasma membraneGO:00058878.2ABCB4, ABCB11, ABCC2, ATP8B1, SLC17A5, SLCO1B3
4plasma membraneGO:00058867.1SLC17A5, SLCO1A2, F2, HLA-G, ATP8B1, ABCC2

Biological processes related to Intrahepatic Cholestasis according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1transportGO:00068109.4SLC25A13, ABCC2, ABCB11, ABCB4
2intracellular receptor signaling pathwayGO:00305229.3NR1I2, NR1I3, NR1H4
3sodium-independent organic anion transportGO:00432529.0SLCO1B3, SLCO1A2
4organic anion transportGO:00157118.9SLCO1A2, SLCO1B3
5bile acid and bile salt transportGO:00157218.7ABCB11, ATP8B1, SLCO1A2, SLCO1B3
6bile acid metabolic processGO:00082068.5SLCO1B3, SLCO1A2, NR1H4, ATP8B1, ABCB11
7transmembrane transportGO:00550857.9ABCB4, ABCB11, ABCC2, ATP8B1, SLCO1A2, SLC17A5
8small molecule metabolic processGO:00442817.7ABCB4, ABCB11, GPT, SLCO1A2, SLCO1B3, SLC25A13

Molecular functions related to Intrahepatic Cholestasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1thyroid hormone receptor activityGO:00048879.8NR1H4, NR1I3
2ATPase activity, coupled to transmembrane movement of substancesGO:00426269.6ABCB4, ABCB11, ABCC2
3ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityGO:00048799.0NR1H4, NR1I3, NR1I2
4organic anion transmembrane transporter activityGO:00085148.7SLCO1B3, SLCO1A2, ABCC2

Products for genes affiliated with Intrahepatic Cholestasis

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Sources for Intrahepatic Cholestasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet