MCID: INT001
MIFTS: 50

Intrahepatic Cholestasis malady

Categories: Genetic diseases, Rare diseases, Liver diseases, Reproductive diseases, Gastrointestinal diseases, Metabolic diseases

Aliases & Classifications for Intrahepatic Cholestasis

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Sources:
10Disease Ontology, 12DISEASES, 65UMLS, 45NIH Rare Diseases, 23Genetics Home Reference, 51Orphanet, 47Novoseek, 36MeSH, 42NCIt, 59SNOMED-CT, 28ICD10 via Orphanet, 37MESH via Orphanet
See all MalaCards sources

Aliases & Descriptions for Intrahepatic Cholestasis:

Name: Intrahepatic Cholestasis 10 12 65
Intrahepatic Cholestasis of Pregnancy 10 45 23 51
Recurrent Intrahepatic Cholestasis of Pregnancy 45 23 51
Pregnancy-Related Cholestasis 45 23 51
Gravidic Intrahepatic Cholestasis 45 51
Familial Recurrent Intrahepatic Cholestasis of Pregnancy 45
Familial Intrahepatic Cholestasis of Pregnancy 45
Cholestasis, Intrahepatic of Pregnancy 45
 
Pregnancy Related Cholestasis 45
Cholestasis, Intrahepatic 36
Cholestasis Intrahepatic 47
Cholestasis of Pregnancy 65
Obstetric Cholestasis 23
Ricp 45
Icp 45

Characteristics:

Orphanet epidemiological data:

51
intrahepatic cholestasis of pregnancy:
Inheritance: Multigenic/multifactorial,Not applicable; Age of onset: Adult

Classifications:



External Ids:

Disease Ontology10 DOID:1852
MeSH36 D002780
NCIt42 C84400
SNOMED-CT59 4637005
Orphanet51 69665
ICD10 via Orphanet28 O26.6
MESH via Orphanet37 C535932
UMLS65 C0008372, C0268318

Summaries for Intrahepatic Cholestasis

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NIH Rare Diseases:45 Intrahepatic cholestasis of pregnancy (icp) is a disorder of the liver that occurs in women during pregnancy. cholestasis is a condition that impairs the release of bile (a digestive juice) from liver cells. the bile then builds up in the liver, impairing liver function. symptoms typically become apparent in the third trimester of pregnancy and can include severe itching (pruritus). occasionally, the skin and the whites of the eyes can have a yellow appearance (jaundice). icp is additionally associated with risks to the developing baby such as premature delivery and stillbirth. the cause of icp is largely unknown, although approximately 15% of cases are caused by mutations in either the abcb11 or abcb4 genes. mutations within the abcb11 and abcb4 genes are inherited in an autosomal dominant manner. symptoms of icp are typically limited to pregnancy. bile flow returns to normal after delivery and the signs and symptoms of the condition disappear, however, they can return during later pregnancies. last updated: 3/15/2016

MalaCards based summary: Intrahepatic Cholestasis, also known as intrahepatic cholestasis of pregnancy, is related to cholestasis, progressive familial intrahepatic 2 and cholestasis, intrahepatic, of pregnancy, 1. An important gene associated with Intrahepatic Cholestasis is ATP8B1 (ATPase Phospholipid Transporting 8B1), and among its related pathways are Codeine and Morphine Pathway, Pharmacokinetics and ABC-family proteins mediated transport. Affiliated tissues include liver, skin and eye, and related mouse phenotypes are liver/biliary system and growth/size/body region.

Genetics Home Reference:23 Intrahepatic cholestasis of pregnancy is a liver disorder that occurs in pregnant women. Cholestasis is a condition that impairs the release of a digestive fluid called bile from liver cells. As a result, bile builds up in the liver, impairing liver function. Because the problems with bile release occur within the liver (intrahepatic), the condition is described as intrahepatic cholestasis. Intrahepatic cholestasis of pregnancy usually becomes apparent in the third trimester of pregnancy. Bile flow returns to normal after delivery of the baby, and the signs and symptoms of the condition disappear. However, they can return during later pregnancies.

Related Diseases for Intrahepatic Cholestasis

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Diseases in the Intrahepatic Cholestasis family:

Cholestasis, Progressive Familial Intrahepatic 2 Cholestasis, Benign Recurrent Intrahepatic, 2
Cholestasis, Progressive Familial Intrahepatic 3 Cholestasis, Progressive Familial Intrahepatic 4
Cholestasis, Progressive Familial Intrahepatic 1 Cholestasis, Benign Recurrent Intrahepatic
Abcb11-Related Intrahepatic Cholestasis Atp8b1-Related Intrahepatic Cholestasis

Diseases related to Intrahepatic Cholestasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 502)
idRelated DiseaseScoreTop Affiliating Genes
1cholestasis, progressive familial intrahepatic 233.8ABCB11, ABCB4, ATP8B1
2cholestasis, intrahepatic, of pregnancy, 133.5ABCB11, ATP8B1
3cholestasis, benign recurrent intrahepatic33.3ABCB11, ABCB4, ATP8B1, GGT1, JAG1, NR1H4
4cholestasis, intrahepatic, of pregnancy, 331.1ABCB11, ABCB4, ATP8B1, JAG1
5low gamma-gt familial intrahepatic cholestasis12.5
6neonatal intrahepatic cholestasis due to citrin deficiency12.5
7abcb11-related intrahepatic cholestasis12.5
8atp8b1-related intrahepatic cholestasis12.5
9cholestasis, progressive familial intrahepatic 112.3
10cholestasis, benign recurrent intrahepatic, 212.1
11cholestasis, progressive familial intrahepatic 312.1
12citrullinemia, type ii, neonatal-onset12.0
13bile acid synthesis defect, congenital, 112.0
14bile acid synthesis defect, congenital, 411.8
15cholestasis, progressive familial intrahepatic 411.6
16atp8b1 deficiency11.5
17lrba-related common variable immune deficiency with autoimmunity10.5ABCB11, ATP8B1
18acid sphingomyelinase deficiency10.5ATP8B1, NR1H4
19prostatitis10.5
20breast cancer10.5
21leukemia10.5
22crigler-najjar syndrome, type ii10.5
23gallbladder disease 110.5
24citrullinemia, adult-onset type ii10.5
25bile acid synthesis defect, congenital, 210.5
26cholestasis-lymphedema syndrome10.5
27cirrhosis, north american indian childhood type10.5
28gilbert syndrome10.5
29hepatitis10.5
30neuronitis10.4
31endotheliitis10.4
32cervicitis10.4
33glioma10.4
34cardiomyopathy, dilated, 1o10.4ABCC2, SLCO1B1
35autoimmune disease of blood10.4ABCB4, GGT1, NR1H4
36head and brain malformations10.4GGT1, SLC17A5, SLC25A13
37prostate cancer10.4
38sarcoma10.4
39biliary atresia10.3GGT1, SLC17A5, SLC25A13
40myocardial infarction10.3
41hepatocellular carcinoma10.3
42obesity10.3
43lymphoma10.3
44melanoma10.3
45cerebritis10.3
46muscular dystrophy10.3
47spasticity10.3
48iron deficiency anemia10.3ABCB4, SLC17A5
49lymphedema10.3ABCB11, ABCB4, ATP8B1, HSD3B7
50suppurative cholangitis10.3ABCB11, ABCB4, NR1H4, NR1I2

Graphical network of the top 20 diseases related to Intrahepatic Cholestasis:



Diseases related to intrahepatic cholestasis

Symptoms for Intrahepatic Cholestasis

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Drugs & Therapeutics for Intrahepatic Cholestasis

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Drugs for Intrahepatic Cholestasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50)    (show all 131)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Ursodeoxycholic acidapproved, investigationalPhase 4, Phase 3, Phase 2, Phase 178128-13-231401
Synonyms:
(3a,5b,7b)-3,7-dihydroxy-cholan-24-oate
(3a,5b,7b)-3,7-dihydroxy-cholan-24-oic acid
(3a,5b,7b)-3,7-dihydroxycholan-24-oic acid
(3alpha,5beta,7beta)-3,7-dihydroxycholan-24-oic acid
(3alpha,5beta,7beta,8xi)-3,7-dihydroxycholan-24-oic acid
(3α,5β,7β)-3,7-dihydroxycholan-24-oic acid
(4R)-4-[(3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid
128-13-2
17-beta-(1-Methyl-3-carboxypropyl)etiocholane-3-alpha,7-beta-diol
3 alpha,7 beta-Dihydroxy-5 beta-cholan-24-oic Acid
3,7-Dihydroxycholan-24-oic acid
3-alpha,7-beta-Dihydroxy-5-beta-cholanoic acid
3-alpha,7-beta-Dihydroxycholanic acid
3-alpha,7-beta-Dioxycholanic acid
3a,7b-Dihydroxy-5b-cholan-24-oate
3a,7b-Dihydroxy-5b-cholan-24-oic acid
3alpha,7beta-Dihydroxy-5beta-cholan-24-oic acid
3alpha,7beta-Dihydroxy-5beta-cholanic acid
4-10-00-01604 (Beilstein Handbook Reference)
50809-41-1
5beta-Cholan-24-oic acid-3alpha,7beta-diol
5beta-Cholanic Acid-3alpha,7beta-diol
7-beta-Hydroxylithocholic acid
7beta-Hydroxylithocholic acid
80225-86-1
AB00513977
AC-18919
AC-2081
AC1L1LJH
Acide ursodesoxycholique
Acide ursodesoxycholique [INN-French]
Acido ursodeossicolico
Acido ursodeossicolico [Italian]
Acido ursodeoxicolico
Acido ursodeoxicolico [INN-Spanish]
Acidum ursodeoxycholicum
Acidum ursodeoxycholicum [INN-Latin]
Actigall
Actigall (TN)
Antigall
Arsacol
BB_NC-2372
BPBio1_001052
BRN 3219888
BSPBio_000956
C07880
C24H40O4
CCRIS 5502
CHEBI:9907
CHEMBL1551
CHEMBL73390
CID11516715
CID31401
CPD-10534
CPD000058403
Cholan-24-oic acid, 3,7-dihydroxy-, (3-alpha,5-beta,7-beta)- (9CI)
Cholit-ursan
D00734
DB01586
Delursan
Deoxyursocholic Acid
Destolit
Deursil
Dom-ursodiol c
EINECS 204-879-3
HMS1570P18
ISO-URSODEOXYCHOLIC ACID
 
IU5
LMST04010033
LS-53033
Litursol
Lyeton
MLS000028461
MLS001066373
MolPort-001-794-630
MolPort-005-932-884
NCGC00179363-01
NCI60_028904
NSC 657950
NSC 683769
PHL-ursodiol c
PMS-ursodiol c
Peptarom
Prestwick0_000958
Prestwick1_000958
Prestwick2_000958
Prestwick3_000958
S1643_Selleck
SAM002264653
SMP2_000012
SMR000058403
SPBio_003105
Sodium Ursodeoxycholate
Solutrat
U-9000
U0030
U5127_SIGMA
UDCA
UDCS
UNII-724L30Y2QR
URSODEOXYCHOLIC ACID
UrSO
Urosdesoxycholate
Urosdesoxycholic acid
Urosiol
Ursacholic Acid
Ursacol
Urso
Urso (TN)
Urso 250
Urso DS
Urso Forte
Ursobilin
Ursochol
Ursodamor
Ursodeoxy cholic acid
Ursodeoxycholate
Ursodeoxycholic acid
Ursodeoxycholic acid (JP15/INN)
Ursodeoxycholic acid, UDCA, Ursosan, Ursofalk, Urso Forte, Udiliv, Ursodiol
Ursodeoxycholicacid
Ursodesoxycholic acid
Ursodexycholate
Ursodexycholic Acid
Ursodexycholic acid
Ursodiol
Ursodiol (USP)
Ursodiol Tablets, 250 mg
Ursodiol Tablets, 500 mg
Ursodiol [USAN]
Ursofalk
Ursolvan
Ursosan
chenodeoxycholic acid
ursodeoxycholate
ursodiol
2
AbataceptapprovedPhase 4139332348-12-610237
Synonyms:
CTLA4-Ig
CTLA4-IgG4m
 
CTLA4Ig
CTLA4IgG4m
Orencia
3
Vitamin Eapproved, nutraceuticalPhase 437159-02-914985
Synonyms:
(+)-a-Tocopherol
(+)-alpha-Tocopherol
(+)-alpha-tocopherol
(+)-α-tocopherol
(2R)-2,5,7,8-TETRAMETHYL-2-[(4R,8R)-4,8,12-trimethyltridecyl]chroman-6-ol
(2R)-3,4-Dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-ol
(2R,4'R,8'R)-a-Tocopherol
(2R,4'R,8'R)-alpha-Tocopherol
(2R,4'R,8'r)-alpha-tocopherol
(R,R,R)-a-Tocopherol
(R,R,R)-alpha-Tocopherol
(R,R,R)-alpha-tocopherol
(R,R,R)-α-tocopherol
5,7,8-Trimethyltocol
Amino-Opti-E
Aquasol E
D-alpha-Tocopherol
Daltose
Denamone
E-200 I.U. Softgels
 
E-Complex-600
E-Ferol
E-Vitamin succinate
Eprolin
Gordo-Vite E
Phytogermin
Phytogermine
RRR-alpha-tocopherol
RRR-alpha-tocopheryl
Tocopherol
Vitamin E
Vitamin Ea
Vitamin Plus E Softgells
Vitamin e
Vitec
a-D-Tocopherol
a-Tocopherol
alpha-Tocopherol
alpha-delta-Tocopherol
d-alpha-tocopherol
d-α-tocopherol
delta-alpha-Tocopherol
4Immunosuppressive AgentsPhase 4, Phase 310422
5Pharmaceutical SolutionsPhase 4, Phase 27004
6Immunologic FactorsPhase 4, Phase 3, Phase 1, Phase 218483
7Gastrointestinal AgentsPhase 4, Phase 3, Phase 2, Phase 16401
8Antirheumatic AgentsPhase 4, Phase 3, Phase 1, Phase 28496
9Liver ExtractsPhase 4, Phase 3, Phase 2, Phase 13572
10TocotrienolsPhase 4372
11Fat Emulsions, IntravenousPhase 429
12Parenteral Nutrition SolutionsPhase 471
13TocopherolsPhase 4376
14methionineNutraceuticalPhase 4, Phase 273
15TocotrienolNutraceuticalPhase 4372
16TocopherolNutraceuticalPhase 4376
17CoconutNutraceuticalPhase 437
18OliveNutraceuticalPhase 4235
19Soy BeanNutraceuticalPhase 4455
20
MethotrexateapprovedPhase 314441959-05-2, 59-05-2126941
Synonyms:
4-amino-10-methylfolic acid
4-amino-N(10)-Methylpteroylglutamic acid
Abitrexate
Amethopterin
Amethopterine
Antifolan
Arbitrexate
Emtexate
Folex
HDMTX
L-Amethopterin
Ledertrexate
MTX
Metatrexan
Methopterin
Methotextrate
 
Methotrate
Methotrexat
Methotrexate
Methotrexate Sodium
Methotrexatum
Methylaminopterin
Methylaminopterinum
Metoject
Metotrexato
Mexate
Méthotrexate
N-Bismethylpteroylglutamic Acid
N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid
Otrexup
Rasuvo
Rheumatrex
Rheumatrex Dose Pack
Trexall
21
ZidovudineapprovedPhase 2, Phase 349130516-87-135370
Synonyms:
-Azido-3&prime
-deoxythymidine
1-(3-Azido-2,3-dideoxy-beta-D-ribofuranosyl)thymine
3&prime
3' Azido 2',3' Dideoxythymidine
3' Azido 3' deoxythymidine
3'-Azido-2',3'-Dideoxythymidine
3'-Azido-3'-deoxythymidine
3'-Azido-3'-deoxythymidine & Concanavalin A
3'-Azido-3'-deoxythymidine & Erythropoietin
3'-Azido-3'-deoxythymidine & Heteropolyoxotungstate PM-19
3'-Azido-3'-deoxythymidine & Interleukin-1
3'-Azido-3'-deoxythymidine & Interleukin-2
3'-Azido-3'-deoxythymidine & Interleukin-6
3'-Azido-3'-deoxythymidine & Lithium & Erythropoietin
3'-Azido-3'-deoxythymidine & Lithium & Interleukin-1
3'-Azido-3'-deoxythymidine & Lithium & Interleukin-6
3'-Azido-3'-deoxythymidine & Lymphoblastoid Interferon
3'-Azido-3'-deoxythymidine & Sho-Saiko-To
3'-Azido-3'-deoxythymidine (AIDS)
3'-Azido-3'deoxythymidine & Interferon .alpha.
3'-Azidothymidine
3'-Deoxy-3'-azidothymidine
3'-azido-3'-deoxythymidine, AZT
3-Azido-3-deoxythymidine
30516-87-1
399024-19-2
A2169_SIGMA
AC1L1TKL
AC1Q2OEK
AZT
AZT & CD4(178)-PE 40
AZT & Colony-stimulating factor 2
AZT & Concanavalin A (ConA)
AZT & EPO
AZT & GM-CSF
AZT & HPA
AZT & IFN.alpha.
AZT & IL-1
AZT & IL-2
AZT & IL-6
AZT & Interferon-.alpha.-2
AZT & Li & EPO
AZT & Li & GM-CSF
AZT & Li & IL-1
AZT & Li & IL-6
AZT & Lymphoblastoid Interferon
AZT & NP (from PHCA or HSA)
AZT & PM-19
AZT & SST
AZT & rIFN.alpha.2
AZT & rsCD4 & rIFN.alpha.A
AZT & rsT4
AZT & sCD4
AZT & srCD4
AZT (Antiviral)
AZT Antiviral
AZT TRANSPLACENTAL CARCINOGENESIS STUDY
AZT+PRO 140
AZT, Antiviral
Antiviral AZT
Apo-Zidovudine
Azidothymidine
Aztec
BB_NC-1012
BPBio1_000403
BRD-K72903603-001-04-6
BSPBio_000365
BSPBio_003153
BW A509U
BW-A 509U
BW-A-509U
BW-A509U
BWA 509U
BWA-509U
BWA509U
C07210
CCRIS 105
CHEBI:10110
CHEBI:127307
CHEMBL129
CID35370
CPD000058351
 
Compound S
Cpd S
D00413
D015215
DB00495
DRG-0004
DS-4152 & AZT
DivK1c_000524
HMS1921J20
HMS2090G11
HMS2092D06
HMS501K06
HSDB 6515
IDI1_000524
Interferon AD + 3'-azido-3'-deoxythymidine
Intron A & AZT
K7 [P Ti2 W10 O40]
KBio1_000524
KBio2_001828
KBio2_004396
KBio2_006964
KBio3_002653
KBioGR_000703
KBioSS_001828
LS-1159
Liposomal AZT-SN-1
Liposomal AZT-SN-3
MLS000028548
MLS001055351
MLS001076358
MLS002153202
MLS002222249
Met-SDF-1.beta. & AZT
Met-SDF-1.beta. & Zidovudine
MolPort-002-507-286
NCGC00023945-03
NCGC00023945-04
NCGC00023945-05
NCGC00023945-08
NCGC00178237-01
NCGC00178237-02
NINDS_000524
NSC 602670
Novo-Azt
PC-SOD+AZT
Prestwick3_000333
Propolis+AZT
Racemic Liposomal AZT
Retrovir
Retrovir (TN)
Retrovir(TM)
SAM002548971
SMR000058351
SN-1-dipalmitoylglycerophospho-AZT (in a lipid vesicle)
SN-3-dipalmitoylglycerophospho-AZT (in a lipid vesicle)
SPBio_000834
SPECTRUM1502109
STK801891
Spectrum2_000927
Spectrum3_001507
Spectrum4_000332
Spectrum5_001101
Spectrum_001348
UNII-4B9XT59T7S
ZDV
ZIDOVUDINE [AZT]
ZINC03779042
ZVD
Zidovudin
Zidovudina
Zidovudina [Spanish]
Zidovudine
Zidovudine (JAN/USP/INN)
Zidovudine EP III
Zidovudine [USAN:INN:BAN:JAN]
Zidovudine+PRO 140
Zidovudinum
Zidovudinum [Latin]
antiviral
azidodeoxythymidine
rIFN-beta seron & AZT
racemic-dipalmitoylglycerophospho-AZT (in a lipid vesicle)
zidovudin
zidovudine
22
ColchicineapprovedPhase 310464-86-86167, 2833
Synonyms:
(S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide
30512-31-3
5843-86-7
64-86-8
7-alpha-H-Colchicine
7.alpha.H-Colchicine
7alphaH-Colchicine
AC1L1LXO
ACon1_000353
AI3-31149
AKOS001582887
BB_NC-0737
BPBio1_000535
BRD-K00259736-001-06-5
BSPBio_000485
BSPBio_002083
Benzo(a)heptalen-9(5H)-one
C 9754
C07592
C22H25NO6
C3915_SIGMA
C9754_SIGMA
CCRIS 691
CHEBI:27882
CHEMBL107
CID6167
CPD-9785
Colchicin
Colchicin [German]
Colchicina
Colchicina [Italian]
Colchicine
Colchicine (JP15/USP)
Colchicine (TN)
Colchicine [JAN]
Colchicine, (+-)-Isomer
Colchicine, (R)-Isomer
Colchicine, Colchicum autumnale
Colchicinum
Colchineos
Colchisol
Colchysat
Colcin
Colcrys
Colsaloid
Colstat
Condylon
D003078
D00570
DB01394
DB08117
DivK1c_000753
EINECS 200-598-5
EU-0100310
Goutnil
HMS1569I07
HMS1920A08
HMS2091G16
HMS502F15
HSDB 3044
IDI1_000753
KBio1_000753
KBio2_001322
KBio2_003890
KBio2_006458
 
KBio3_001303
KBioGR_000856
KBioSS_001322
Kolkicin
LOC
LS-279
Lopac0_000310
MEGxp0_001879
MLS001055448
MLS001055448-02
MLS001304089
MLS002153786
MPC-004
Mitigare
MolPort-001-742-594
N-((7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)- acetamide
N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)acetamide
N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[.alpha.]heptalen-7-yl)-acetamide
N-Acetyl trimethylcolchicinic acid methylether
N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide
N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide
NCGC00025125-01
NCGC00025125-02
NCGC00025125-03
NCGC00025125-04
NCGC00025125-05
NCGC00025125-06
NCGC00025125-07
NCGC00025125-11
NCGC00169157-01
NCGC00169157-02
NCGC00169157-03
NCI60_041659
NChemBio.2007.10-comp20
NINDS_000753
NSC 757
NSC757
Prestwick0_000363
Prestwick1_000363
Prestwick2_000363
Prestwick3_000363
Prestwick_695
S2284_Selleck
SDCCGMLS-0066633.P001
SID26747941
SID49671357
SMR000058323
SPBio_000289
SPBio_002406
SPECTRUM1500205
Spectrum2_000075
Spectrum3_000362
Spectrum4_000298
Spectrum5_000787
Spectrum_000842
Tocris-1364
UNII-SML2Y3J35T
UPCMLD-DP065
UPCMLD-DP065:001
WLN: L B677 MV&T&J CO1 DO1 EO1 JMV1 NO1
ZINC00621853
binds to tubulin
colchicine
inhibits microtubular assembly
nchembio853-comp2
spindle poison
23
Tauroursodeoxycholic acidapproved, investigationalPhase 31214605-22-212443252
Synonyms:
2-(((3-alpha,5-beta,7-beta)-3,7-Dihydroxy-24-oxocholan-24-yl) amino)ethanesulfonate
2-(((3-alpha,5-beta,7-beta)-3,7-Dihydroxy-24-oxocholan-24-yl) amino)ethanesulfonic acid
2-(((3-alpha,5-beta,7-beta)-3,7-Dihydroxy-24-oxocholan-24-yl)amino)-Ethanesulfonate
2-(((3-alpha,5-beta,7-beta)-3,7-Dihydroxy-24-oxocholan-24-yl)amino)-Ethanesulfonic acid
3a,7b-Dihydroxy-5b-cholanoyltaurine
 
N-(3-alpha,7-beta-Dihydroxy-5-beta-cholan-24-oyl)-Taurine
TUDCA
Tauroursodeoxycholate
Tauroursodeoxycholic acid
UR 906
Ursodeoxycholyltaurine
24
Lamivudineapproved, investigationalPhase 2, Phase 3594134678-17-460825
Synonyms:
(+/-) (Cis)-1-[2-(Hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine
(+/-)-3TC
(+/-)-BCH-189
(+/-)-SddC
(-)-(2'R,5'S)-1-[2'-Hydroxymethyl-5'-(1,3-oxathiolanyl)]cytosine
(-)-1-((2R,5S)-2-(Hydroxymethyl)-1,3-oxathiolan-5-yl)cytosine
(-)-1-[(2R,5S)-2-(Hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine
(-)-2'-Deoxy-3'-thiacytidine
(-)-BCH 189
(-)-BCH-189
(-)-SddC
(-)-beta-L-2',3'-Dideoxy-3'-thiacytidine
(-)NGPB-21
(2R,cis)-4-amino-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-one
.beta.-L-(-)-2',3'-dideoxy-3'-thiacytidine & Sho-Saiko-To
134678-17-4
2',3' Dideoxy 3' thiacytidine
2',3'-Dideoxy-3'-thiacytidine
2(1H)-Pyrimidinone, 4-amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl], (+/-) (Cis)
2(1H)-Pyrimidinone, 4-amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl], (-)(2R,5S)
2(1H)-Pyrimidinone, 4-amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl], (-)(2R,5S) & Galanthus Nivalis Agglutinin (GNA)
2(1H)-Pyrimidinone, 4-amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl], (-)(2R,5S) & Hippeastrum hybrid agglutinin( HHA)
3'-Thia-2',3'-dideoxycytidine
3-TC
3TC
3TC & GNA
3TC & SST
3TC (AIDS INITIATIVE) (AIDS INITIATIVE)
3TC and NV-01
3TC, Zeffix, Heptovir, Epivir, Epivir-HBV, Lamivudine
4-Amino-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-2(1H)-pyrimidinone
4-amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2(1H)-one
4-amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2-one
480434-79-5
AC-1416
AC1L1TZZ
AC1Q6C34
BCH 189
BCH-189
BCH-790
BCH189
BIDD:GT0033
Bio-0652
C07065
C8H11N3O3S
CCRIS 9274
CHEBI:133986
CHEMBL141
CID60825
CPD000466319
D00353
D019259
DB00709
 
DRG-0126
DTHC
Epivir
Epivir (TN)
Epivir HBV
Epivir(TM)
Epivir-HBV
Epzicom
FT-0082667
GG-714
GR 109714 X
GR 109714X
GR-109714X
GR109714X
HHA & 3TC
HHA & Lamivudine
HMS2051D21
HSDB 7155
Hepitec
Heptivir
Heptodin
Heptovir
L0217
LMV
LS-2107
Lamivir
Lamivudin
Lamivudina
Lamivudine
Lamivudine & GNA
Lamivudine (JAN/USP/INN)
Lamivudine [USAN:BAN:INN]
Lamivudine [USAN:INN:BAN]
Lamivudine [Usan:Ban:Inn]
Lamivudine, (2S-cis)-Isomer
Lamivudinum
MLS000759424
MLS001424097
MolPort-002-507-347
NCGC00159341-03
NCGC00159341-04
NSC620753
S1706_Selleck
SAM001246582
SAM002589994
SMR000466319
STK801940
UNII-2T8Q726O95
ZINC00012346
Zeffix
Zefix
beta-L-2',3'-Dideoxy-3'-thiacytidine
beta-L-3'-Thia-2',3'-dideoxycytidine
lamivudine
25
chenodeoxycholic acidapprovedPhase 3, Phase 225474-25-910133
Synonyms:
(+)-chenodeoxycholate
(+)-chenodeoxycholic acid
(3a,5b,7a)-3,7-dihydroxy-cholan-24-oate
(3a,5b,7a)-3,7-dihydroxy-cholan-24-oic acid
3a,7a-Dihydroxy-5b,14a,17b-cholanate
3a,7a-Dihydroxy-5b,14a,17b-cholanic acid
3a,7a-Dihydroxy-5b-cholan-24-oate
3a,7a-Dihydroxy-5b-cholan-24-oic acid
3a,7a-Dihydroxy-5b-cholanate
3a,7a-Dihydroxy-5b-cholanic acid
3alpha,7alpha-Dihydroxy-5beta-cholanic acid
7a-Hydroxy-desoxycholsaeure
 
7alpha-Hydroxylithocholic acid
Anthropodeoxycholic acid
Anthropodesoxycholic acid
CDCA
Chenic acid
Chenix
Chenocholic acid
Chenodal
Chenodeoxycholate
Chenodeoxycholic acid
Chenodesoxycholic acid
Chenodesoxycholsaeure
Chenodiol
Gallodesoxycholic acid
26
BudesonideapprovedPhase 3, Phase 138151333-22-363006, 5281004
Synonyms:
(11-beta,16-alpha)-16,17-(Butylidenebis(oxy))-11,21-dihydroxypregna-1,4-diene-3,20-dione
(11beta,16alpha)-16,17-(Butylidenebis(oxy))-11,21-dihydroxypregna-1,4-diene-3,20-dione
(4aR,4bS,5S,6aS,6bS,8R,9aR,10aS,10bS)-5-hydroxy-6b-(hydroxyacetyl)-4a,6a-dimethyl-8-propyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
(4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-5-hydroxy-6b-(hydroxyacetyl)-4a,6a-dimethyl-8-propyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
(R,S)-11b,16a,17,21,tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with buty raldehyde
(RS)-(11beta,16alpha)-16,17-[Butylidenebis(oxy)]-11,21-dihydroxypregna-1,4-diene-3,20-dione
(RS)-11beta,16alpha,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with butyraldehyde
(S)-16alpha,17-(Butylidenedioxy)-11beta,21-dihydroxypregna-1,4-diene-3,20-dione
11beta,21-dihydroxy-16alpha,17alpha-(butane-1,1-diyldioxy)pregna-1,4-diene-3,20-dione
16,17-Butylidenebis(oxy)-11,21-dihydroxypregna-1,4-diene-3,20-dione
16,17-Butylidenebis(oxy)-11-,21-dihydroxypregna-1,4-diene-3,20-dione
16-alpha,17-alpha-Butylidenedioxy-11-beta,21-dihydroxy-1,4-pregnadiene-3,20-dione
16alpha(R),17-(Butylidenebis(oxy))-11beta,21-dihydroxypregna-1,4-diene-3,20-dione
16alpha-,17alpha--butylidenedioxypregna-1,4-diene-11beta-,21-diol-3,20-dione
51333-22-3
AC-4697
AC1L1DQE
AC1L1Y6Y
AC1L22VC
AC1MHWI7
B 7777
B7777_SIGMA
BPBio1_000523
BRD-A34299591-001-03-4
BRD-A82238138-001-01-7
BSPBio_000475
BSPBio_002160
Bidien
Bio-0010
Budecort Inhaler
Budenofalk
Budeson
Budesonide
Budesonide (JAN/USAN/INN)
Budesonide Easyhaler
Budesonide Inhalation
Budesonide MMX
Budesonide Nasal
Budesonide [USAN:INN:BAN:JAN]
Budesonido
Budesonido [INN-Spanish]
Budesonidum
Budesonidum [INN-Latin]
Budiair
Budicort
C25H34O6
CCRIS 5230
CHEBI:3207
CHEBI:656601
CHEMBL1370
CID2462
CID3033890
CID40000
CID5281004
CID63006
CPD000058337
Cortivent
D00246
DB01222
Desowen
Dexbudesonide
Dexbudesonide [INN]
DivK1c_000475
EINECS 257-139-7
EINECS 257-160-1
EINECS 257-161-7
EU-0100174
Entocort
Entocort EC
Entocort EC (TN)
Giona Easyhaler
HMS1569H17
HMS1921I22
HMS2094I13
HMS501H17
 
Horacort
IDI1_000475
Inflammide
KBio1_000475
KBio3_001660
KBioGR_001361
LS-187734
LS-7235
Lopac0_000174
MAP-0010
MLS000028507
MLS001077323
MLS002207112
Micronyl
Miflonide
MolPort-002-529-265
MolPort-003-666-332
MolPort-003-986-909
NCGC00015165-03
NCGC00021318-03
NCGC00021318-06
NCGC00089747-02
NCGC00089747-03
NCGC00089747-04
NCGC00178789-01
NINDS_000475
Noex
Preferid
Pregna-1,4-diene-3,20-dione, 16,17-butylidenebis(oxy)-11,21-dihydroxy-, (11beta,16alpha(R))-, and 16alpha,17-((S)-Butylidenebis(oxy))-11beta,21-dihydroxypregna-1,4-diene-3,20-dione
Prestwick0_000518
Prestwick1_000518
Prestwick2_000518
Prestwick3_000518
Prestwick_840
Pulmaxan
Pulmaxan turbohaler
Pulmicort
Pulmicort (TN)
Pulmicort FLEXHALER
Pulmicort Flexhaler
Pulmicort Nebuamp
Pulmicort Respules
Pulmicort Topinasal
Pulmicort Turbuhaler
Pulmicort turbuhaler
Respules
Rhinocort
Rhinocort Aqua
Rhinocort Turbuhaler
Rhinocort alpha
Rhinocort, Pulmicort , Entocort, Symbicort, Noex. Entocort EC, Budesonide
Rhinosol
S 1320
S-1320
S1286_Selleck
SAM002699898
SMR000058337
SPBio_000586
SPBio_002396
SPECTRUM1500813
ST51039033
Spectrum2_000623
Spectrum3_000620
Spectrum4_000821
Spectrum5_001738
Spirocort
TL8003397
Tridesilon
UDB
UNII-168L5HT37P
UNII-2HI1006KPH
UNII-Q3OKS62Q6X
Uceris
Unit dose budesonide
ZINC03938751
ZINC04097286
budesonide
27
BezafibrateapprovedPhase 31241859-67-039042
Synonyms:
2-(4-{2-[(4-chlorobenzoyl)amino]ethyl}phenoxy)-2-methylpropanoic acid
2-(P-(2-(P-Chlorobenzamido)ethyl)phenoxy)-2-methylpropionic acid
2-(p-(2-(p-Chlorobenzamido)ethyl)phenoxy)-2-methylpropionic acid
2-[4-(2-[4-Chlorobenzamido]ethyl)- phenoxy]-2-methylpropanoic acid
2-[4-[2-(4-Chlorobenzamido)ethyl]phenoxy]-2-methylpropanoic acid
2-[4-[2-(4-Chlorobenzamido)ethyl]phenoxy]isobutyric Acid
2-[4-[2-[(4-chlorobenzoyl)amino]ethyl]phenoxy]-2-methylpropanoic acid
41859-67-0
AB00052265
AB1004588
AC-6817
AC1L20XS
AC1Q5E4V
AKOS005107743
Azufibrat
Azupharma Brand of Bezafibrate
B3346
B7273_SIGMA
BF-759
BM 15.075
BM 15075
BM-15.075
BM-15075
BM15.075
BPBio1_000589
BRD-K46018455-001-06-0
BRN 4267656
BSPBio_000535
BSPBio_001314
BSPBio_003119
Bayer Brand of Bezafibrate
Befibrat
Befizal
Berlin Chemie Brand of Bezafibrate
Berlin-Chemie Brand of Bezafibrate
Betapharm Brand of Bezafibrate
Beza Lande
Beza Puren
Beza-Lande
Beza-Puren
BezaLande
BezaPuren
Bezabeta
Bezacur
Bezafibrat
Bezafibrat PB
Bezafibrate (JP15/USAN/INN)
Bezafibrate Azupharma Brand
Bezafibrate Bayer Brand
Bezafibrate Berlin-Chemie Brand
Bezafibrate Betapharm Brand
Bezafibrate Cryopharma Brand
Bezafibrate Elfar Brand
Bezafibrate Hennig Brand
Bezafibrate Hexal Brand
Bezafibrate Isis Brand
Bezafibrate Lakeside Brand
Bezafibrate Merckle Brand
Bezafibrate Roche Brand
Bezafibrate Synthelabo Brand
Bezafibrate TAD Brand
Bezafibrate Teva Brand
Bezafibrate [USAN:BAN:INN:JAN]
Bezafibrato
Bezafibrato [INN-Spanish]
Bezafibrato [Spanish]
Bezafibrato [inn-spanish]
Bezafibratum
Bezafibratum [INN-Latin]
Bezafibratum [inn-latin]
Bezafisal
Bezalip
Bezalip Retard
Bezamerck
Bezatol
Bezatol SR
Bezatol SR (TN)
Bezatol sr (tn)
Bio2_000034
Bio2_000514
Boehringer Mannheim Brand of Bezafibrate
C19H20ClNO4
CAS-41859-67-0
CCRIS 9085
CHEBI:47612
 
CHEMBL264374
CID39042
Cedur
Cryopharma Brand of Bezafibrate
D001629
D01366
DB01393
DB08380
Difaterol
DivK1c_000092
EINECS 255-567-9
Elfar Brand of Bezafibrate
Eulitop
HMS1361B16
HMS1569K17
HMS1791B16
HMS1921H16
HMS1989B16
HMS2089F04
HMS2092B12
HMS500E14
Hennig Brand of Bezafibrate
Hexal Brand of Bezafibrate
I06-1311
IDI1_000092
IDI1_033784
Isis Brand of Bezafibrate
KBio1_000092
KBio2_000034
KBio2_001923
KBio2_002602
KBio2_004491
KBio2_005170
KBio2_007059
KBio3_000067
KBio3_000068
KBio3_002619
KBioGR_000034
KBioGR_000669
KBioSS_000034
KBioSS_001923
LO 44
LS-124535
Lakeside Brand of Bezafibrate
Lipox
MLS000028533
MLS001148205
Merckle Brand of Bezafibrate
MolPort-001-738-424
NCGC00016850-01
NCGC00016850-02
NCGC00016850-11
NCGC00023317-03
NCGC00023317-04
NCGC00023317-05
NCGC00023317-06
NCGC00023317-07
NCGC00023317-08
NINDS_000092
PB, Bezafibrat
Prestwick0_000378
Prestwick1_000378
Prestwick2_000378
Prestwick3_000378
Prestwick_724
Reducterol
Regadrin B
Roche Brand of Bezafibrate
SMR000058298
SPBio_000824
SPBio_002456
SPECTRUM1502046
ST51014927
Sklerofibrat
Solibay
Spectrum2_000922
Spectrum3_001500
Spectrum4_000325
Spectrum5_001079
Spectrum5_001967
Spectrum_001443
Synthelabo Brand of Bezafibrate
TAD Brand of Bezafibrate
Teva Brand of Bezafibrate
a-[4-(4-chlorobenzoylaminoethyl)phenoxy]isobutyric acid
bezafibrate
durabezur
28
Folic Acidapproved, nutraceuticalPhase 3292459-30-36037
Synonyms:
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
01769_FLUKA
2d0k
33609-88-0
36653-55-1 (mono-potassium salt)
59-30-3
6484-89-5 (mono-hydrochloride salt)
AC-11682
AC1L1LNX
AI3-26387
AKOS000503224
ARONIS014410
Acfol (Spain)
Acide folique
Acide folique [INN-French]
Acido folico
Acido folico [INN-Spanish]
Acidum folicum
Acidum folicum [INN-Latin]
Acifolic
Antianemia factor
Apo-Folic
BIDD:ER0563
BIDD:GT0641
BIF0608
BPBio1_000654
BSPBio_000594
BSPBio_002338
C00504
C20H20N6O6
CAS-59-30-3
CCRIS 666
CHEBI:27470
CHEMBL1622
CID6037
CPD000471860
Cytofol
D00070
DB00158
DivK1c_000494
Dosfolat B activ
EINECS 200-419-0
F0043
F7876_SIAL
F7876_SIGMA
F8758_SIGMA
F8798_SIAL
F8890_SIGMA
FOL
Facid
Factor U
Folacid
Folacin
Folaemin
Folaemin [Netherlands]
Folan
Folasic (Australia)
Folate
Folbal
Folcidin
Folcidin (VAN)
Folcysteine
Foldine
Foldine [France]
Folettes
Foliamin
Folic
Folic Acid
Folic acid
Folic acid (JP15/USP/INN)
Folic acid (TN)
Folic acid [BAN:INN:JAN]
Folic acid [INN:BAN:JAN]
Folic acid dihydrate
Folicet
Folicet (TN)
Folico
Folico (Italy)
Folina
Folina (Italy)
Folipac
 
Folsaeure
Folsan
Folsaure
Folsav
Folvite
Folvron
Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L
HMS1921D20
HMS2092N17
HMS501I16
HSDB 2002
IDI1_000494
InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s
Incafolic
KBio1_000494
KBio2_001861
KBio2_004429
KBio2_006997
KBio3_001558
KBioGR_002222
KBioSS_001861
Kyselina listova
Kyselina listova [Czech]
LS-2157
Liver Lactobacillus casei factor
MLS001304016
MLS001335861
Millafol
Mission prenatal
Mittafol
MolPort-004-285-551
N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid
N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-(4-{[(2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-Pteroyl-L-glutamic acid
N-[(4-{[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
NCGC00016265-01
NCGC00142391-01
NINDS_000494
NSC 3073
Nifolin
Nifolin [Denmark]
Novofolacid
Novofolacid [Canada]
PGA
PGA (VAN)
Prestwick3_000627
Prestwick_230
PteGlu
Pteroyl-L-glutamate
Pteroyl-L-glutamic acid
Pteroyl-L-monoglutamate
Pteroyl-L-monoglutamic acid
Pteroylglutamate
Pteroylglutamic acid
Pteroylmonoglutamate
Pteroylmonoglutamic acid
SAM002264616
SDCCGMLS-0066738.P001
SMP2_000137
SMR000471860
SPBio_001357
SPECTRUM1502020
Serum Folate Level
Spectrum2_001459
Spectrum3_000749
Spectrum4_001751
Spectrum5_000602
Spectrum_001381
UNII-935E97BOY8
Usaf cb-13
Vitamin B11
Vitamin B9
Vitamin Bc
Vitamin Be
Vitamin M
bmse000299
folic acid
nchembio.108-comp10
29
TetrathiomolybdateinvestigationalPhase 31516330-92-05245480
Synonyms:
 
ATN-224
30Antimetabolites, AntineoplasticPhase 35770
31Reverse Transcriptase InhibitorsPhase 2, Phase 31656
32Nucleic Acid Synthesis InhibitorsPhase 2, Phase 33836
33Lamivudine, zidovudine drug combinationPhase 2, Phase 3110
34Tubulin ModulatorsPhase 34279
35Antimitotic AgentsPhase 34296
36Vitamin B ComplexPhase 32847
37Peripheral Nervous System AgentsPhase 3, Phase 118510
38Folic Acid AntagonistsPhase 31643
39Dermatologic AgentsPhase 3, Phase 24555
40Angiogenesis Modulating AgentsPhase 33611
41Hydroxymethylglutaryl-CoA Reductase InhibitorsPhase 31804
42Anti-Retroviral AgentsPhase 2, Phase 32794
43Anti-Infective AgentsPhase 3, Phase 2, Phase 117220
44Calcium, DietaryPhase 34678
45Atorvastatin CalciumPhase 3714134523-03-8
46Phase 3
47Anticholesteremic AgentsPhase 31732
48AntimetabolitesPhase 3, Phase 29454
49Antiviral AgentsPhase 3, Phase 28071
50Hypolipidemic AgentsPhase 3, Phase 22228

Interventional clinical trials:

(show top 50)    (show all 88)
idNameStatusNCT IDPhase
1Ursofalk Tablets (500 mg) Versus Ursofalk Capsules (250 mg) in the Treatment of Primary Biliary CirrhosisCompletedNCT01510860Phase 4
2Effectiveness of S-adenosyl-L-methionine in Patients With Primary Biliary CirrhosisRecruitingNCT02557360Phase 4
3Study of Abatacept (Orencia) to Treat Primary Biliary CirrhosisRecruitingNCT02078882Phase 4
4Reduction of Neonatal Parenteral Nutrition Associated Cholestasis Through Lipid EmulsionsActive, not recruitingNCT02633384Phase 4
5Ursodeoxycholic Acid in the Treatment of Intrahepatic Cholestasis of PregnancyCompletedNCT01576458Phase 3
6Study With Heptral in Subjects With Liver Disease Due to Alcohol ConsumptionCompletedNCT02200029Phase 3
7Safety and Efficacy of Long-Term Treatment With Atorvastatin in Patients With Primary Biliary CirrhosisCompletedNCT00844402Phase 3
8Safety and Efficacy of Tauroursodeoxycholic Acid Versus Ursofalk in the Treatment of Adult Primary Biliary CirrhosisCompletedNCT01857284Phase 3
9Study Comparing Tetrathiomolybdate vs Standard Treatment in Primary Biliary CirrhosisCompletedNCT00805805Phase 3
10Study of Combivir for Patients With Primary Biliary CirrhosisCompletedNCT00490620Phase 2, Phase 3
11Ursodiol-Methotrexate for Primary Biliary CirrhosisCompletedNCT00006168Phase 3
12Phase III Randomized Study of Ursodiol With Vs Without Methotrexate for Primary Biliary CirrhosisCompletedNCT00004784Phase 3
13Low-Dose Oral Methotrexate Versus Colchicine for Primary Biliary CirrhosisCompletedNCT00004748Phase 3
14Phase 3 Study of Obeticholic Acid Evaluating Clinical Outcomes in Patients With Primary Biliary CirrhosisRecruitingNCT02308111Phase 3
15Phase 3 Study of Bezafibrate in Combination With Ursodeoxycholic Acid in Primary Biliary CirrhosisActive, not recruitingNCT01654731Phase 3
16Phase 3 Study of Obeticholic Acid in Patients With Primary Biliary CirrhosisActive, not recruitingNCT01473524Phase 3
17Ursodeoxycholic Acid Plus Budesonide Versus Ursodeoxycholic Acid Alone in Primary Biliary Cirrhosis (PBC)Active, not recruitingNCT00746486Phase 3
18Magnetic Resonance Cholangiopancreatography Versus Endoscopic Retrograde Cholangiopancreatography in the Approach to Patients With Suspected Biliary ObstructionTerminatedNCT01424657Phase 3
19Ursodeoxycholic Acid And Cholestasis Of PregnancyWithdrawnNCT01226823Phase 3
20A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of Repeat Doses of GSK2330672 Administration in Subjects With Primary Biliary Cirrhosis (PBC) and Symptoms of PruritusCompletedNCT01899703Phase 2
21Safety and Efficacy Study of LUM001 in the Treatment of Cholestatic Liver Disease in Patients With Alagille SyndromeCompletedNCT01903460Phase 2
22Phase 2 Study of NGM282 in Patients With Primary Biliary CirrhosisCompletedNCT02026401Phase 2
23Phase 2 Study to Evaluate LUM001 in Combination With Ursodeoxycholic Acid in Patients With Primary Biliary CirrhosisCompletedNCT01904058Phase 2
24A Study of Efficacy and Safety of Ustekinumab in Patients With Primary Biliary Cirrhosis (PBC) Who Had an Inadequate Response to Ursodeoxycholic AcidCompletedNCT01389973Phase 2
25Pentoxifylline for Primary Biliary CirrhosisCompletedNCT01249092Phase 2
26Moexipril for Primary Biliary CirrhosisCompletedNCT00588302Phase 2
27Use of Fenofibrate for Primary Biliary CirrhosisCompletedNCT00575042Phase 2
28Study of INT-747 as Monotherapy in Patients With PBCCompletedNCT00570765Phase 2
29Study of INT 747 in Combination With URSO in Patients With Primay Biliary Cirrhosis (PBC)CompletedNCT00550862Phase 2
30Initial Study of Rituximab to Treat Primary Biliary CirrhosisCompletedNCT00364819Phase 1, Phase 2
31Treatment of Cholestatic Pruritus With SertralineCompletedNCT00058903Phase 2
32Umbilical Cord Mesenchymal Stem Cells for Patients With Primary Biliary CirrhosisRecruitingNCT01662973Phase 1, Phase 2
33An Extension Study to Evaluate the Long-Term Safety and Durability of Effect of LUM001 in the Treatment of Cholestatic Liver Disease in Subjects With Alagille SyndromeRecruitingNCT02117713Phase 2
34Study to Evaluate the Effects of Two Doses of MBX-8025 in Subjects With Primary Biliary Cirrhosis (PBC)RecruitingNCT02609048Phase 2
35A Multi-part, Double Blind Study to Assess Safety, Tolerability and Efficacy of LJN452 in PBC PatientsRecruitingNCT02516605Phase 2
36IBAT Inhibitor A4250 for Cholestatic PruritusRecruitingNCT02360852Phase 2
37Pilot Study of FFP104 Dose Escalation in PBC SubjectsRecruitingNCT02193360Phase 1, Phase 2
38Phase 2b Study of NGM282 Extended Treatment in Patients With Primary Biliary CirrhosisRecruitingNCT02135536Phase 2
39Evaluation of LUM001 in the Reduction of Pruritus in Alagille SyndromeRecruitingNCT02057692Phase 2
40Open Label Study to Evaluate Efficacy and Long Term Safety of LUM001 in the Treatment of Cholestatic Liver Disease in Patients With Progressive Familial Intrahepatic CholestasisActive, not recruitingNCT02057718Phase 2
41An Extension Study to Evaluate the Long-Term Safety and Durability of Effect of LUM001 in the Treatment of Cholestatic Liver Disease in Subjects With Alagille SyndromeActive, not recruitingNCT02047318Phase 2
42B-Cell Depleting Therapy (Rituximab) as a Treatment for Fatigue in Primary Biliary CirrhosisActive, not recruitingNCT02376335Phase 2
43A Long-Term, Open-Label Study of LUM001 With a Double-Blind, Placebo Controlled, Randomized Drug Withdrawal Period to Evaluate Safety and Efficacy in Children With Alagille SyndromeActive, not recruitingNCT02160782Phase 2
44Phase 2 Study on Effects of Obeticholic Acid (OCA) on Lipoprotein Metabolism in Subjects With Primary Biliary CirrhosisActive, not recruitingNCT01865812Phase 2
45Second-line Therapy of Unresectable Cholangiocarcinoma by RADIOEMBOLIZATIONTerminatedNCT01383746Phase 1, Phase 2
46Primary Biliary Cirrhosis: Investigating A New Treatment Option Using NI-0801, an Anti-CXCL10 Monoclonal AntibodyTerminatedNCT01430429Phase 2
47SAMe to Treat Biliary Cirrhosis SymptomsTerminatedNCT00125281Phase 2
48An Open-label Study to Evaluate the Long-term Safety and Tolerability of LUM001 in Patients With Primary Biliary CirrhosisWithdrawnNCT02321306Phase 2
49Fenofibrate in Combination With Ursodeoxycholic Acid (UDCA) in Primary Biliary CirrhosisWithdrawnNCT01141296Phase 2
50Biliary Excretion of Conjugated Bile Acids in Humans Measured by 11C-cholylsarcosine PET/CTCompletedNCT01879735Phase 1

Search NIH Clinical Center for Intrahepatic Cholestasis


Cochrane evidence based reviews: cholestasis, intrahepatic

Genetic Tests for Intrahepatic Cholestasis

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Anatomical Context for Intrahepatic Cholestasis

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MalaCards organs/tissues related to Intrahepatic Cholestasis:

33
Liver, Skin, Eye, Bone, Breast, Endothelial, B cells

Animal Models for Intrahepatic Cholestasis or affiliated genes

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MGI Mouse Phenotypes related to Intrahepatic Cholestasis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.9ABCB11, ABCB4, ABCC2, ATP8B1, HSD3B7, JAG1
2MP:00053788.2ABCB11, ABCB4, ATP8B1, ENPP2, GGT1, HSD3B7
3MP:00107688.0ABCB11, ATP8B1, ENPP2, GGT1, HSD3B7, JAG1
4MP:00053767.2ABCB11, ABCB4, ABCC2, ATP8B1, ENPP2, GGT1

Publications for Intrahepatic Cholestasis

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Articles related to Intrahepatic Cholestasis:

(show top 50)    (show all 723)
idTitleAuthorsYear
1
MiR-21, miR-34a, miR-198 and miR-217 as diagnostic and prognostic biomarkers for chronic pancreatitis and pancreatic ductal adenocarcinoma. (25908274)
2015
2
Prednisolone and azathioprine are effective in DPPX antibody-positive autoimmune encephalitis. (25798450)
2015
3
Pediatric pheochromocytoma and paraganglioma: an update. (25373696)
2014
4
MDR1 transporter protects against paraquat-induced toxicity in human and mouse proximal tubule cells. (25015657)
2014
5
CREB-induced inflammation is important for malignant mesothelioma growth. (25111229)
2014
6
Impact of the superoxide dismutase 2 Val16Ala polymorphism on the relationship between valproic acid exposure and elevation of I^-glutamyltransferase in patients with epilepsy: a population pharmacokinetic-pharmacodynamic analysis. (25372290)
2014
7
Imbalance between vascular endothelial growth factor and endostatin correlates with the prognosis of operable non-small cell lung cancer. (24998915)
2014
8
Predictors of acute stress disorder severity. (23466400)
2013
9
Cross-species approaches to pathological gambling: A review targeting sex differences, adolescent vulnerability and ecological validity of research tools. (23867802)
2013
10
WNT6 is a novel target gene of caveolin-1 promoting chemoresistance to epirubicin in human gastric cancer cells. (22370641)
2013
11
Population frequency and age of c.806C > T mutation in CYB5R3 gene as cause of recessive congenital methemoglobinemia in Yakutia]. (23866629)
2013
12
CASZ1 inhibits cell cycle progression in neuroblastoma by restoring pRb activity. (23797594)
2013
13
Acute maternal cytomegalovirus infection is associated with significantly decreased numbers of CD34+ cells in umbilical cord blood. (22818857)
2012
14
Dedifferentiated subserosal liposarcoma of the jejunum: sonographic and computed tomographic findings with pathologic correlation. (22726982)
2012
15
Cytokine serum levels in patients with cervical intraepithelial neoplasia grade II-III treated with intralesional interferon-I+ 2b. (22158487)
2011
16
How complicated is complicated diverticulitis?--phlegmonous diverticulitis revisited. (21830036)
2011
17
Orbital cellulitis in children-medical treatment versus surgical management. (19839897)
2009
18
Selective PKC beta inhibition with ruboxistaurin and endothelial function in type-2 diabetes mellitus. (18949545)
2009
19
Sunitinib in the management of gastrointestinal stromal tumours (GISTs). (18082353)
2008
20
ADP-ribosylation factor 1 controls the activation of the phosphatidylinositol 3-kinase pathway to regulate epidermal growth factor-dependent growth and migration of breast cancer cells. (18990689)
2008
21
Levels of sex steroid and cardiovascular disease measures in premenopausal and hormone-treated women at midlife: implications for the "timing hypothesis". (18955645)
2008
22
Klotho-related protein is a novel cytosolic neutral beta- glycosylceramidase. (17595169)
2007
23
p53-mediated activation of miRNA34 candidate tumor-suppressor genes. (17656095)
2007
24
Cytotoxic activity of violacein in human colon cancer cells. (16889929)
2006
25
Analysis of host- and tumor-derived proteinases using a custom dual species microarray reveals a protective role for stromal matrix metalloproteinase-12 in non-small cell lung cancer. (16912171)
2006
26
The initial substrate-binding site of gamma-secretase is located on presenilin near the active site. (15722417)
2005
27
Cytogenetic aberrations in perineurioma: variation with subtype. (16096405)
2005
28
Complex evolution of orthologous and paralogous decarboxylase genes. (15000648)
2004
29
Neuroendocrine disturbances in obesity]. (15382610)
2004
30
Phorbol ester induces CYP2E1 in astrocytes, through a protein kinase C- and tyrosine kinase-dependent mechanism. (12887687)
2003
31
In vivo association of the stability control protein alphaCP with actively translating mRNAs. (12529395)
2003
32
A novel DKC1 mutation, severe combined immunodeficiency (T+B-NK-SCID) and bone marrow transplantation in an infant with Hoyeraal-Hreidarsson syndrome. (12437656)
2002
33
Comparison of the effects of different antiviral treatments on the antioxidant systems of stroma-free hemoglobin. (11594061)
2001
34
Hla-DR2-restricted responses to proteolipid protein 95-116 peptide cause autoimmune encephalitis in transgenic mice. (10841661)
2000
35
Proximal median mononeuropathy associated with an anomalous deep course through the brachialis muscle. (11032638)
2000
36
Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin. (10433268)
1999
37
Cherubism: a study of three generations. (11507493)
1998
38
A special kind of anterior horn cell involvement in juvenile myoclonic epilepsy demonstrated by macro electromyography. (9040651)
1997
39
Increased basal and induced tyrosine phosphorylation of the insulin-like growth factor I receptor beta subunit in circulating mononuclear cells of patients with polycythemia vera. (7542500)
1995
40
Evidence for distinct DNA binding forms of the erythroid-specific transcription factor NF-E2. (8845360)
1995
41
Photodynamic therapy. Its use in the management of bronchogenic carcinoma. (8521700)
1995
42
Immunohistochemical study of estrogen receptor-related antigen, progesterone and estrogen receptors in human intracranial meningiomas. (8033047)
1994
43
Recombinant thyroid peroxidase-specific autoantibodies. I. How diverse is the pool of heavy and light chains in immunoglobulin gene libraries constructed from thyroid tissue-infiltrating plasma cells. (8013349)
1994
44
Ameloblastic fibro-odontoma of the anterior maxilla. Report of a case. (8378043)
1993
45
High melanosome engulfing activity of cutaneous fibroblasts in macular amyloidosis: an electron microscopic study. (6520256)
1984
46
Complete primary structure of human C4a anaphylatoxin. (6167582)
1981
47
Alterations in lung macrophage antimicrobial activity associated with viral pneumonia. (232689)
1979
48
Viral encephalitis: a clinical, electroencephalographic, virological and pathological study in 32 cases. (765268)
1975
49
50

Variations for Intrahepatic Cholestasis

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Expression for genes affiliated with Intrahepatic Cholestasis

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Search GEO for disease gene expression data for Intrahepatic Cholestasis.

Pathways for genes affiliated with Intrahepatic Cholestasis

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Pathways related to Intrahepatic Cholestasis according to GeneCards Suite gene sharing:

(show all 13)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
10.0ABCC2, SLCO1B1
2
Show member pathways
10.0ABCB11, ABCB4, ABCC2
39.9GGT1, GGT3P
4
Show member pathways
9.9NR1H4, NR1I2, NR1I3
5
Show member pathways
9.8ABCC2, NR1I2, NR1I3
6
Show member pathways
9.8ABCC2, NR1I2, SLCO1B1
7
Show member pathways
9.7ABCC2, SLCO1A2, SLCO1B1
8
Show member pathways
9.5ABCB11, ABCC2, SLCO1A2, SLCO1B1
9
Show member pathways
9.4ABCB11, ABCB4, ABCC2, SLCO1A2, SLCO1B1
109.3ABCB11, ABCB4, ABCC2, NR1H4, NR1I2, NR1I3
119.2ABCB11, ABCC2, NR1H4, NR1I2, NR1I3, SLCO1B1
12
Show member pathways
9.2ABCB11, HSD3B7, NR1H4, SLC10A2, SLCO1A2, SLCO1B1
139.0ABCB11, ABCB4, ABCC2, NR1H4, SLC10A2, SLCO1A2

GO Terms for genes affiliated with Intrahepatic Cholestasis

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Cellular components related to Intrahepatic Cholestasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1membraneGO:00160208.8ABCB11, ABCB4, ABCC2, ATP8B1, SLC10A2, SLC17A5

Biological processes related to Intrahepatic Cholestasis according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1xenobiotic transportGO:004290810.7ABCB4, NR1I2
2drug transmembrane transportGO:000685510.3ABCB4, ATP8B1, TMEM30A
3sodium-independent organic anion transportGO:004325210.3SLCO1A2, SLCO1B1
4phospholipid translocationGO:004533210.3ATP8B1, TMEM30A
5leukotriene biosynthetic processGO:001937010.0GGT1, GGT3P
6glutathione metabolic processGO:00067499.9GGT1, GGT3P
7bile acid metabolic processGO:00082069.8HSD3B7, SLC10A2, SLCO1A2, SLCO1B1
8transmembrane transportGO:00550859.1ABCB4, ABCC2, ATP8B1, SLC17A5, SLCO1A2

Molecular functions related to Intrahepatic Cholestasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1bile acid transmembrane transporter activityGO:001512510.1SLCO1A2, SLCO1B1
2thyroid hormone receptor activityGO:000488710.0NR1I2, NR1I3
3RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA bindingGO:00048799.7NR1I2, NR1I3

Sources for Intrahepatic Cholestasis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet