Intrahepatic Cholestasis of Pregnancy malady

Genetics Home Reference: Intrahepatic cholestasis of pregnancy is a liver disorder that occurs in pregnant women. Cholestasis is a condition that impairs the release of a digestive fluid called bile from liver cells. As a result, bile builds up in the liver, impairing liver function. Because the problems with bile release occur within the liver (intrahepatic), the condition is described as intrahepatic cholestasis. Intrahepatic cholestasis of pregnancy usually becomes apparent in the third trimester of pregnancy. Bile flow returns to normal after delivery of the baby, and the signs and symptoms of the condition disappear. However, they can return during later pregnancies.¹⁷

MalaCards: Intrahepatic Cholestasis of Pregnancy, also known as recurrent intrahepatic cholestasis of pregnancy, is related to intrahepatic cholestasis and benign recurrent intrahepatic cholestasis. An important gene associated with Intrahepatic Cholestasis of Pregnancy is ABCB4 (ATP-binding cassette, sub-family B (MDR/TAP), member 4), and among its related pathways are Cell adhesion molecules (CAMs) and Pravastatin Pathway, Pharmacokinetics. The compounds vincristine and egcg have been mentioned in the context of this disorder. Affiliated tissues include liver, placenta and t cells, and related mouse phenotypes are endocrine/exocrine gland and respiratory system.

Wikipedia: Intrahepatic cholestasis of pregnancy, termed obstetric cholestasis in the United Kingdom, (also known...⁴⁴ more...

OMIM: 147480

intrahepatic cholestasis of pregnancy 30 17 recurrent intrahepatic cholestasis of pregnancy 30 17 familial intrahepatic cholestasis of pregnancy 30 16 familial recurrent intrahepatic cholestasis of pregnancy 30 cholestasis, familial intrahepatic, of pregnancy 33 cholestasis, intrahepatic of pregnancy 30 recurrence (disease attribute) 43 pregnancy related cholestasis 30

pregnancy-related cholestasis 17 intrahepatic cholestasis 43 cholestasis of pregnancy 43 obstetric cholestasis 17 cholestasis 43 ricp 30 icp 30

Diseases related to intrahepatic cholestasis of pregnancy by text searches and GeneDecks gene sharing:

(show top 50)    (show all 563)

id	Related Disease	Score	Top Affiliating Genes
1	intrahepatic cholestasis	38.0	ATP8B1, HLA-G, NR1H4, NR1I2, ABCB11, ABCB4
2	benign recurrent intrahepatic cholestasis	37.3	ATP8B1, ABCB11
3	cholestasis, progressive familial intrahepatic 1	36.0	ATP8B1, NR1H4, ABCB11, ABCB4, GGT1
4	neonatal intrahepatic cholestasis caused by citrin deficiency	34.7	GPT, F2, SLC17A5
5	citrin deficiency	34.1	GPT, F2, SLC17A5
6	cholestasis, progressive familial intrahepatic 3	33.8	ATP8B1, ABCB11, ABCB4
7	low gamma-gt familial intrahepatic cholestasis	33.8	ATP8B1, ABCB11
8	herpes simplex	33.7	BCL2, BAX, IL2RA, APOE, GPT, TP53
9	cholestasis, progressive familial intrahepatic 2	32.8	ATP8B1, ABCB11, ABCB4
10	extrahepatic cholestasis	32.3	ABCC1, ABCC2, GGT1
11	choledocholithiasis	31.4	GPT, ABCB4, SLC17A5, GGT1
12	hepatitis	29.5	GPT, F2, HLA-DRB1, SLC17A5, GGT1
13	diarrhea	27.1	ATP8B1, APOE, GPT, F2, CYP1B1, CYP3A4
14	immunodeficiency	27.0	IL2RA, HLA-DQB1, HLA-DRB1, HLA-G, AHSG, TGFB2
15	hepatoblastoma	26.6	BCL2, BAX, F2, TP53, CYP3A4, NR1H4
16	hepatitis c	26.4	GPT, F2, HLA-DRB1, ABCB4, ABCB7, ABCC2
17	gestational diabetes	26.0	HLA-DQA1, HLA-DQB1, HLA-DRB1, SHBG, EDN1, AHSG
18	cholestasis	26.0	BCL2, BAX, LAP3, CES1, ATP8B1, IL2RA
19	primary biliary cirrhosis	25.5	GPT, F2, HLA-DRB1, CYP3A4, NR1H4, NR1I2
20	jaundice	25.2	LAP3, ATP8B1, IL2RA, GPT, F2, HLA-DQA1
21	iron overload	25.0	GPT, F2, ESR1, ABCB7, SLC17A5, GGT1
22	breast cancer	24.4	BCL2, ESR1, ESR2, TP53, CYP1A1, CYP1B1
23	malignant glioma	24.2	BCL2, BAX, GPT, F2, HLA-DQB1, TP53
24	biliary atresia	24.2	ATP8B1, GPT, F2, HLA-DQA1, HLA-DQB1, HLA-DRB1
25	hypoxia	23.9	BCL2, BAX, APOE, GPT, F2, ESR1
26	liver cirrhosis	23.7	GPT, F2, HLA-DRB1, CYP1A1, CYP3A4, EDN1
27	cholelithiasis	23.6	APOE, GPT, F2, ESR1, ESR2, NR1H4
28	hypercholesterolemia	22.4	CES1, IL2RA, APOE, GPT, F2, ESR1
29	thyroid carcinoma	22.3	BCL2, BAX, ESR1, ESR2, HLA-DQA1, HLA-DQB1
30	liver cancer	22.2	BCL2, BAX, GPT, F2, ESR2, TP53
31	pancreatic cancer	22.0	BCL2, BAX, IL2RA, GPT, ESR1, ESR2
32	cystic fibrosis	20.6	BAX, LAP3, IL2RA, GPT, F2, ESR1
33	sarcoma	20.6	BCL2, BAX, IL2RA, APOE, GPT, ESR1
34	blindness	20.3	CES1, IL2RA, APOE, GPT, F2, ESR1
35	fibrosis	19.7	BCL2, BAX, LAP3, IL2RA, APOE, GPT
36	melanoma	18.5	BCL2, BAX, LAP3, IL2RA, GPT, F2
37	pancreatitis	18.4	BCL2, BAX, LAP3, CES1, ATP8B1, IL2RA
38	hypertension	17.9	BAX, LAP3, APOE, GPT, F2, ESR1
39	ovarian cancer	17.6	BCL2, BAX, IL2RA, APOE, GPT, F2
40	carcinoma	17.2	BCL2, BAX, LAP3, CES1, IL2RA, APOE
41	hepatocellular carcinoma	17.0	BCL2, BAX, CES1, IL2RA, APOE, GPT
42	diabetes mellitus	16.8	BCL2, BAX, LAP3, IL2RA, APOE, GPT
43	thyroiditis	16.5	BCL2, BAX, IL2RA, APOE, GPT, F2
44	rotor syndrome	13.7	ABCC2, SLCO1B3
45	digestive diseases	13.6	GPT, ABCB4, GGT1
46	cerebrotendinous xanthomatosis	13.5	CYP3A4, NR1H4, NR1I2
47	fuchs' heterochromic uveitis	13.4	IL2RA, TGFB2
48	antley-bixler syndrome	13.4	CYP1B1, CYP3A4, CYP17A1
49	giant cell hepatitis	13.4	CYP1A1, CYP1B1, CYP17A1, GGT1
50	primary sclerosing cholangitis	13.3	GPT, NR1I2, ABCB4, ABCC2, GGT1

Clinical features from OMIM: 147480

Approved drugs:

Drug clinical trials:

Genetic tests related to intrahepatic cholestasis of pregnancy:

id	Genetic test	Affiliating Genes
1	Intrahepatic Cholestasis Of Pregnancy clinical/research	ABCB4

MalaCards organs/tissues related to intrahepatic cholestasis of pregnancy:

²²

MGI Mouse Phenotypes related to intrahepatic cholestasis of pregnancy:

²⁵ (show all 19)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	10.4	SLC4A2, GGT1
2	respiratory system phenotype	MP:0005388	10.0	EPAS1, APOE
3	reproductive system phenotype	MP:0005389	10.0	SLC4A2, ABCB4, NR1I2, ESR2
4	hematopoietic system phenotype	MP:0005397	9.2	HLA-DQA1, EPAS1, BCL2, HLA-DQB1
5	liver/biliary system phenotype	MP:0005370	8.5	ESR2, TP53, ATP8B1, HIF1A, SLCO1B3, EPAS1
6	immune system phenotype	MP:0005387	8.4	ABCC1, TP53, SLCO1A2, HLA-DQA1, HLA-DQB1, F2
7	limbs/digits/tail phenotype	MP:0005371	8.3	TGFB2, ESR2, APOE, BAX, GGT1, ESR1
8	skeleton phenotype	MP:0005390	8.0	TGFB2, EPAS1, HIF1A, SLC4A2, TP53, ESR2
9	hearing/vestibular/ear phenotype	MP:0005377	7.8	APOE, SLC4A2, BCL2, BAX, SLC17A5, TGFB2
10	renal/urinary system phenotype	MP:0005367	7.4	BCL2, TGFB2, BAX, APOE, ESR1, ESR2
11	nervous system phenotype	MP:0003631	7.1	ABCC1, BAX, ATP8B1, F2, ESR2, HLA-DQB1
12	digestive/alimentary phenotype	MP:0005381	6.9	APOE, SLC4A2, BCL2, F2, ESR1, ESR2
13	vision/eye phenotype	MP:0005391	6.8	EPAS1, GGT1, APOE, TGFB2, HIF1A, CYP1B1
14	mortality/aging	MP:0010768	6.8	SLC4A2, IL2RA, APOE, F2, HLA-DQB1, TP53
15	growth/size phenotype	MP:0005378	6.8	HIF1A, ABCB7, APOE, BCL2, BAX, TP53
16	muscle phenotype	MP:0005369	6.1	AHSG, HIF1A, EDN1, TP53, HLA-DQB1, ESR1
17	cardiovascular system phenotype	MP:0005385	5.3	ABCB7, APOE, F2, ESR2, HLA-DQB1, CYP1A1
18	cellular phenotype	MP:0005384	4.9	ESR1, F2, APOE, IL2RA, BAX, BCL2
19	homeostasis/metabolism phenotype	MP:0005376	3.3	F2, NR1I2, NR1H4, CYP17A1, CYP1B1, CYP1A1

Articles related to intrahepatic cholestasis of pregnancy:

(show top 50)    (show all 54)

id	Title	Authors	Year	Affiliating Genes
1	Alteration in placental expression of bile acids tran sporters OATP1A2, OATP1B1, OATP1B3 in intrahepatic cholestasis of pregnancy. (22203093)	Wang H.... Wang Z.	2011	SLCO1B3
2	The c.504T>C (p.Asn168Asn) polymorphism in the ABC B4 gene as a predisposing factor for intrahepatic cholestasis of pregnancy in G reece. (19840247)	Kitsiou-Tzeli S.... Tsezou A.	2010	ABCB4
3	Is increased maternal endothelin-1 concentration asso ciated with neonatal asphyxia and preterm delivery in intrahepatic cholestasis of pregnancy? (19862540)	Kebapcilar A.G.... Gokulu S.G.	2010	EDN1, AHSG
4	Genetic determinants of drug-induced cholestasis and intrahepatic cholestasis of pregnancy. (20422497)	Pauli-Magnus C.... Stieger B.	2010	NR1H4, ABCB4
5	Combined functional variants of hepatobiliary transpo rters and FXR aggravate intrahepatic cholestasis of pregnancy. (19490418)	Zimmer V.... Lammert F.	2009	NR1H4
6	ABCB4 gene mutations and single-nucleotide polymorphi sms in women with intrahepatic cholestasis of pregnancy. (19584064)	Bacq Y.... Andres C.R.	2009	ABCB4
7	Intrahepatic cholestasis of pregnancy: when should you look further? (19266607)	Hardikar W.... Angus P.	2009	ABCB4
8	A new splicing site mutation of the ABCB4 gene in intrahepatic cholestasis of pregnancy with raised serum gamma-GT. (19261551)	Tavian D.... Coviello D.A.	2009	GGT1, ABCB4
9	Bile acid transport correlative protein mRNA expressi on profile in human placenta with intrahepatic cholestasis of pregnancy. (19882051)	Cui T.... Xing A.	2009	ABCC1, ABCC2, SLC4A2
10	Hepatobiliary phospholipid transporter ABCB4, MDR3 gene variants in a large cohort of Italian women with intrahepatic cholestasis of pregnancy. (18083082)	Floreani A.... Mazzella G.	2008	ABCB4
11	Association of gene polymorphisms of CYP1B1 with intrahepatic cholestasis of pregnancy (18575334)	Wang X.L.... Zou H.	2008	CYP1B1
12	Sequencing and functional assessment of hPXR (NR1I2) variants in intrahepatic cholestasis of pregnancy. (18800312)	Owen B.M.... Dixon P.H.	2008	NR1I2
13	The polymorphism of HLA-DR and -DQ allelic genes associated with intrahepatic cholestasis of pregnancy. (18554163)	Ding Y.... Yang X.	2008	HLA-DQB1, HLA-DRB1
14	Association of the multidrug-resistance-associated protein gene (ABCC2) variants with intrahepatic cholestasis of pregnancy. (17997497)	Sookoian S.... Pirola C.J.	2008	ABCC2
15	Study on relationship between expression of familial intrahepatic cholestasis 1 mRNA in placenta and Intrahepatic cholestasis of pregnancy (18575333)	Xu Z.... Xing A.Y.	2008	ATP8B1
16	Recurrent intrahepatic cholestasis of pregnancy and chain-like choledocholithiasis in a female patient with stop codon in the ABDC4-gene of the hepatobiliary phospholipid transporter (18188816)	Muehlenberg K.... Lammert F.	2008	ABCB4
17	Association between CYP1A1 gene polymorphism and intrahepatic cholestasis of pregnancy (18247309)	Wang X.... Su P.C.	2008	CYP1A1
18	Increased susceptibility for intrahepatic cholestasis of pregnancy and contraceptive-induced cholestasis in carriers of the 1331T>C polymorphism in the bile salt export pump. (18176959)	Meier Y.... Pauli-Magnus C.	2008	ABCB11, ABCC2
19	Linkage between a new splicing site mutation in the MDR3 alias ABCB4 gene and intrahepatic cholestasis of pregnancy. (17187437)	Schneider G.... Reichel C.	2007	ABCB11, ABCB4, ATP8B1
20	Expression of human leucocyte antigen G on human placenta and its gene polymorphism in relation to intrahepatic cholestasis of pregnancy (17961331)	Peng B.... Zou H.	2007	HLA-G
21	Functional variants of the central bile acid sensor FXR identified in intrahepatic cholestasis of pregnancy. (17681172)	van Mil S.W.... Williamson C.	2007	NR1H4
22	Expression of HIF-1alpha mRNA and HIF-2alpha mRNA in placentas of pregnant women with intrahepatic cholestasis of pregnancy (17718430)	Hu Y.Y.... Liu S.Y.	2007	HIF1A, EPAS1
23	Relationship of human leucocyte antigen G, E with intrahepatic cholestasis of pregnancy (17953356)	Peng B.... Hu M.	2007	HLA-G, HLA-E
24	Potential role of trans-inhibition of the bile salt export pump by progesterone metabolites in the etiopathogenesis of intrahepatic cholestasis of pregnancy. (16458994)	Vallejo M.... Marin J.J.	2006	CES1
25	Combined mutations of canalicular transporter proteins cause severe intrahepatic cholestasis of pregnancy. (16890614)	Keitel V.... Kubitz R.	2006	ABCB11, ABCB4
26	Association between polymorphisms of CYP17 and CYP3A4 genes and intrahepatic cholestasis of pregnancy in Chengdu (16909599)	Zhang L.... Wu L.	2006	CYP3A4, CYP17A1
27	Study on the association between estrogen receptor alpha gene polymorphism and intrahepatic cholestasis of pregnancy (16762184)	Zhang L.... Xing A.Y.	2006	ESR1
28	Intrahepatic cholestasis of pregnancy: three novel MDR3 gene mutations. (16696816)	Floreani A.... Mazzella G.	2006	ABCB4
29	The relationship between P53 and hypoxia-inducible transcription factor-1alpha in the placenta of patient with intrahepatic cholestasis of pregnancy under acute hypoxic condition (17236590)	Hu Y.Y.... Liu S.Y.	2006	TP53, HIF1A
30	An associated analysis of estrogen receptor 2 gene polymorphism linked with intrahepatic cholestasis of pregnancy (16883534)	Zhang L.... Chen Y.H.	2006	ESR2
31	Sequence variation in the ATP8B1 gene and intrahepatic cholestasis of pregnancy. (15657619)	Painter J.N.... Aittomaki K.	2005	ATP8B1
32	ATP8B1 mutations in British cases with intrahepatic cholestasis of pregnancy. (15888793)	Muellenbach R.... Williamson C.	2005	ATP8B1
33	Ursodeoxycholic acid in the treatment of intrahepatic cholestasis of pregnancy. A 12-year experience. (15910492)	Zapata R.... Silva J.J.	2005	GPT
34	Effects of oral and transdermal estradiol administration on levels of sex hormone-binding globulin in postmenopausal women with and without a history of intrahepatic cholestasis of pregnancy. (15784702)	Ropponen A.... Ylikorkala O.	2005	SHBG
35	Sequence analysis of bile salt export pump (ABCB11) and multidrug resistance p-glycoprotein 3 (ABCB4, MDR3) in patients with intrahepatic cholestasis of pregnancy. (15077010)	Pauli-Magnus C.... Kullak-Ublick G.A.	2004	ABCB11, ABCB4
36	Increased serum levels of neopterin and soluble interleukin-2 receptor in intrahepatic cholestasis of pregnancy. (15488124)	Wang Z.... He J.	2004	IL2RA
37	Influence of transforming growth factor-beta2 on production of tumor necrosis factor-alpha and interferon-gamma from placenta of intrahepatic cholestasis of pregnancy (15196415)	Ai Y.... Liu S.Y.	2004	TGFB2
38	ABCB4 gene sequence variation in women with intrahepatic cholestasis of pregnancy. (12746424)	Mullenbach R.... Williamson C.	2003	ABCB4
39	Genetic evidence of heterogeneity in intrahepatic cholestasis of pregnancy. (12801961)	Savander M.... Aittomaki K.	2003	ABCB11, ABCB4, ATP8B1
40	Association of single nucleotide polymorphisms of the bile salt export pump gene with intrahepatic cholestasis of pregnancy. (12825874)	Eloranta M.L.... Heinonen S.	2003	ABCB11
41	Human leucocyte antigen-DPA1 polymorphism distribution in Chengdu Chinese families with intrahepatic cholestasis of pregnancy (12910711)	Zhang L.... Chen X.	2003	HLA-DPA1
42	Relationship between p53, bax and bcl-2 expression and cell apoptosis in intrahepatic cholestasis of pregnancy (12757648)	Wang D.M.... Ma D.	2003	TP53, BCL2, BAX
43	Relationship between human leukocyte antigen-DRB1 allele gene polymorphism and intrahepatic cholestasis of pregnancy (12411009)	Chen F.... Yao F.	2002	HLA-DRB1
44	Intrahepatic cholestasis of pregnancy. (12572710)	den Dulk M.... Beyer G.P.	2002	ABCB7
45	Apolipoprotein E alleles in women with intrahepatic cholestasis of pregnancy. (11063158)	Eloranta M.L.... Heinonen S.	2000	APOE
46	Heterozygous MDR3 missense mutation associated with intrahepatic cholestasis of pregnancy: evidence for a defect in protein trafficking. (10767346)	Dixon P.H.... Williamson C.	2000	ABCB4
47	Heterozygous non-sense mutation of the MDR3 gene in familial intrahepatic cholestasis of pregnancy. (9923886)	Jacquemin E.... Hadchouel M.	1999	ABCB4
48	S-adenosylmethionine versus ursodeoxycholic acid in t he treatment of intrahepatic cholestasis of pregnancy: preliminary results of a controlled trial. (8841797)	Floreani A.... Grella P.V.	1996	SLC17A5
49	Intrahepatic cholestasis in pregnancy. The hepatologist's point of view (8228018)	Bacq Y.	1993	F2, GPT
50	Changes in hepatobiliary enzymes and its isoenzymes in intrahepatic cholestasis in pregnancy (1677617)	Chen Y.	1991	GGT1, LAP3

Genes related to intrahepatic cholestasis of pregnancy according to GeneCards:

(show all 40)

id	Symbol	Description	Score	GeneCards Section Context
1	ABCB4	ATP-binding cassette, sub-family B (MDR/TAP), member 4	11.0	Publications
2	ATP8B1	ATPase, aminophospholipid transporter, class I, type 8B, member 1	11.0	Publications
3	SLC4A2	solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)	11.0	Publications
4	ABCB11	ATP-binding cassette, sub-family B (MDR/TAP), member 11	11.0	Publications
5	NR1H4	nuclear receptor subfamily 1, group H, member 4	11.0	Publications
6	LAP3	leucine aminopeptidase 3	11.0	Publications
7	HLA-E	major histocompatibility complex, class I, E	11.0	Publications
8	AHSG	alpha-2-HS-glycoprotein	11.0	Publications
9	ABCC2	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	11.0	Publications
10	HLA-DPA1	major histocompatibility complex, class II, DP alpha 1	11.0	Publications
11	CES1	carboxylesterase 1	11.0	Publications
12	ABCB7	ATP-binding cassette, sub-family B (MDR/TAP), member 7	11.0	Publications
13	SLCO1A2	solute carrier organic anion transporter family, member 1A2	11.0	Publications
14	EPAS1	endothelial PAS domain protein 1	11.0	Publications
15	HLA-G	major histocompatibility complex, class I, G	11.0	Publications
16	NR1I2	nuclear receptor subfamily 1, group I, member 2	11.0	Publications
17	CYP17A1	cytochrome P450, family 17, subfamily A, polypeptide 1	11.0	Publications
18	SLCO1B3	solute carrier organic anion transporter family, member 1B3	11.0	Publications
19	CYP1B1	cytochrome P450, family 1, subfamily B, polypeptide 1	11.0	Publications
20	TGFB2	transforming growth factor, beta 2	11.0	Publications
21	HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1	11.0	Publications
22	GGT1	gamma-glutamyltransferase 1	11.0	Publications
23	GPT	glutamic-pyruvate transaminase (alanine aminotransferase)	11.0	Publications
24	SHBG	sex hormone-binding globulin	11.0	Publications
25	IL2RA	interleukin 2 receptor, alpha	11.0	Publications
26	SLC17A5	solute carrier family 17 (anion/sugar transporter), member 5	11.0	Publications
27	HLA-DRB1	major histocompatibility complex, class II, DR beta 1	11.0	Publications
28	CYP3A4	cytochrome P450, family 3, subfamily A, polypeptide 4	11.0	Publications
29	CYP1A1	cytochrome P450, family 1, subfamily A, polypeptide 1	11.0	Publications
30	BAX	BCL2-associated X protein	11.0	Publications
31	ABCC1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	11.0	Publications
32	EDN1	endothelin 1	11.0	Publications
33	HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	11.0	Publications
34	HLA-DQB1	major histocompatibility complex, class II, DQ beta 1	11.0	Publications
35	ESR2	estrogen receptor 2 (ER beta)	11.0	Publications
36	APOE	apolipoprotein E	11.0	Publications
37	TP53	tumor protein p53	11.0	Publications
38	ESR1	estrogen receptor 1	11.0	Publications
39	BCL2	B-cell CLL/lymphoma 2	11.0	Publications
40	F2	coagulation factor II (thrombin)	11.0	Publications

Pathways related to intrahepatic cholestasis of pregnancy according to GeneDecks:

(show top 50)    (show all 67)

id	Pathway	Score	Top Affiliating Genes
1	Cell adhesion molecules (CAMs)20	10.5	HLA-G, HLA-DPA1, HLA-E
2	Pravastatin Pathway, Pharmacokinetics34	10.4	ABCC2, ABCB11, SLCO1B3
3	Graft-versus-host disease20	10.3	HLA-G, HLA-DQA1, HLA-E, HLA-DPA1
4	Methotrexate Pathway, Pharmacokinetics34	10.3	SLCO1A2, ABCC1, ABCC2
5	Colorectal cancer20	10.3	TGFB2
6	Mycophenolic acid Pathway, Pharmacokinetics34	10.2	SLCO1B3, ABCC2, CYP3A4, CES1
7	Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics34	10.2	ABCC2, SLCO1B3, CYP3A4
8	ABC transporters20	10.1	ABCB11, ABCB4, ABCB7, ABCC2, ABCC1
9	Statin Pathway - Generalized, Pharmacokinetics34	10.1	ABCB11, CYP3A4, SLCO1B3, SLCO1A2, ABCC2
10	Irinotecan Pathway, Pharmacokinetics34	10.1	CES1, CYP3A4, ABCC2, ABCC1
11	Benzo[a]pyrene metabolism41	10.1	CYP3A4, CYP1A1, CYP1B1
12	Benzo[a]pyrene metabolism10	10.1	CYP1A1, CYP1B1, CYP3A4
13	Carbamazepine Pathway, Pharmacokinetics34	10.0	NR1I2, CYP3A4, ABCC2
14	MHC class II antigen presentation38	9.9	HLA-DQA1, HLA-DRB1, HLA-DQB1, HLA-DPA1
15	Etoposide Pathway, Pharmacokinetics/Pharmacodynamics34	9.9	ABCC1, CYP3A4, NR1I2
16	Asthma20	9.9	HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DPA1
17	Immune response Antigen presentation by MHC class II10	9.9	HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRB1
18	Immune response_Antigen presentation by MHC class II41	9.9	HLA-DQA1, HLA-DPA1, HLA-DRB1, HLA-DQB1
19	Bile secretion20	9.8	ABCB11, ABCB4, SLCO1B3, CYP3A4, SLC4A2, ABCC2
20	Intestinal immune network for IgA production20	9.8	HLA-DQA1, HLA-DRB1, HLA-DQB1, HLA-DPA1
21	Calcium Mediated T-Cell Apoptosis36	9.8	HLA-DPA1, HLA-DQA1, HLA-DRB1, HLA-DQB1
22	G-protein signaling N-RAS regulation pathway10	9.8	HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRB1
23	Estradiol metabolism10	9.8	CYP3A4, CYP1B1, CYP1A1
24	Taxane Pathway, Pharmacokinetics34	9.8	CYP3A4, SLCO1B3, ABCC2, ABCC1, NR1I2, CYP1B1
25	G-protein signaling_N-RAS regulation pathway41	9.7	HLA-DQB1, HLA-DPA1, HLA-DQA1, HLA-DRB1
26	Leishmaniasis20	9.7	HLA-DQA1, TGFB2, HLA-DQB1, HLA-DRB1, HLA-DPA1
27	THC Differentiation Pathway36	9.7	HLA-DPA1, IL2RA, HLA-DRB1, HLA-DQA1, HLA-DQB1
28	Steroid hormone biosynthesis20	9.7	CYP17A1, CYP1B1, CYP1A1, CYP3A4
29	CTL Mediated Apoptosis36	9.7	HLA-DRB1, HLA-G, HLA-E, HLA-DQB1, HLA-DQA1, HLA-DPA1
30	Staphylococcus aureus infection20	9.7	HLA-DQB1, HLA-DQA1, HLA-DPA1, HLA-DRB1
31	Allograft rejection20	9.7	HLA-DPA1, HLA-DQA1, HLA-DRB1, HLA-E, HLA-DQB1, HLA-G
32	Type I diabetes mellitus20	9.7	HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-E, HLA-G
33	Autoimmune thyroid disease20	9.7	HLA-DPA1, HLA-E, HLA-DRB1, HLA-G, HLA-DQB1, HLA-DQA1
34	Viral myocarditis20	9.7	HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-E, HLA-G, HLA-DPA1
35	Antigen processing and presentation20	9.7	HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-E, HLA-G, HLA-DPA1
36	Rheumatoid arthritis20	9.7	HLA-DPA1, HLA-DRB1, TGFB2, HLA-DQA1, HLA-DQB1
37	ICos-ICosL Pathway in T-Helper Cell36	9.7	HLA-DQA1, HLA-DPA1, HLA-DQB1, HLA-DRB1, IL2RA
38	Phagosome20	9.6	HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-E, HLA-G
39	CDC42 Pathway36	9.6	HLA-E, HLA-DQA1, HLA-DRB1, HLA-DPA1, HLA-G, HLA-DQB1
40	Estradiol metabolism41	9.5	CYP1B1, CYP1A1, CYP3A4
41	Doxorubicin Pathway (Cancer Cell), Pharmacodynamics34	9.4	ABCC2, ABCC1, TP53
42	Metabolism of lipids and lipoproteins38	9.3	ABCB11, ABCC1, SLCO1A2, CYP17A1, APOE, GGT1
43	Vinka Alkaloid Pathway, Pharmacokinetics34	9.1	BCL2, BAX, CYP3A4, ABCC1, ABCC2
44	IL-4 Pathway36	9.1	HLA-DRB1, HLA-DQB1, HLA-DQA1, BCL2, HLA-DPA1
45	Immune response IL-22 signaling pathway10	8.9	HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPA1, IL2RA, BCL2
46	Toxoplasmosis20	8.9	HLA-DRB1, TGFB2, HLA-DQB1, HLA-DQA1, BCL2, HLA-DPA1
47	Immune response_IL-22 signaling pathway41	8.9	IL2RA, HLA-DRB1, HLA-DQA1, HLA-DPA1, BCL2, HLA-DQB1
48	Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR210	8.7	ESR1, BAX, BCL2, ESR2
49	Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR241	8.7	ESR2, BCL2, BAX, ESR1
50	Tuberculosis20	8.7	HLA-DRB1, HLA-DQB1, HLA-DQA1, BAX, BCL2, HLA-DPA1

Compounds related to intrahepatic cholestasis of pregnancy according to GeneDecks:

(show top 50)    (show all 353)

id	Compound	Score	Top Affiliating Genes
1	vincristine32 34 9 9	13.7	ABCB4, ABCB11
2	egcg32	10.3	TGFB2
3	glycocholate32	9.7	ABCC1, ABCB4, SLC17A5, ABCC2, ABCB11, GPT
4	taurocholate32	9.7	ATP8B1, SLCO1B3, ABCC2, ABCC1, ABCB4, ABCB11
5	cholic acid32 9 18 9	12.6	SLCO1B3, SLCO1A2, ABCC1, ABCC2, CES1, ABCB11
6	rifampin34 9 9	11.6	ABCB11, SLCO1B3, SLCO1A2, ABCC2, ABCC1, CYP3A4
7	chenodeoxycholic acid32 9 18 9	12.5	GPT, NR1H4, NR1I2, ABCB11, ABCB4, SLCO1B3
8	ketoconazole32 42 9 18 9	13.3	NR1I2, SHBG, SLCO1A2, ABCC2, CYP17A1, ABCB11
9	creatinine32	9.2	LAP3, SHBG, HLA-G, GGT1, IL2RA, ABCC2
10	estrone sulfate32 18	10.0	ESR1, CYP1B1, CYP17A1, SHBG, ABCC1, ABCC2
11	ritonavir32 34 9 9	11.9	NR1I2, SLCO1A2, ABCC2, ABCB11, CYP3A4, APOE
12	rifampicin32	8.9	GPT, CYP1A1, CYP3A4, NR1I2, ABCB11, ABCC1
13	phenobarbital32 9 9	10.9	ABCC2, NR1I2, GPT, GGT1, SLCO1A2, ABCC1
14	flutamide32 9 9	10.8	SLC17A5, GPT, ESR1, CYP1A1, CYP1B1, CYP3A4
15	tacrolimus32 34 9 9	11.8	NR1I2, GPT, CYP3A4, HIF1A, GGT1, ABCB11
16	verapamil32 34 9 18 9	12.7	IL2RA, GPT, CYP3A4, EDN1, ABCB11, ABCB4
17	bezafibrate32 9 9	10.7	GGT1, SLC17A5, ABCB4, CYP3A4, CYP1A1, GPT
18	acetaminophen32 34 9 18 9	12.6	CYP3A4, CYP1A1, F2, GPT, NR1I2, ABCC2
19	digoxin32 42 34 9 18 9	13.6	SLCO1B3, SLC17A5, HIF1A, ABCC2, ABCC1, ABCB11
20	daunorubicin32 9 9	10.4	ABCC2, ABCC1, ABCB4, ABCB11, CYP3A4, CYP1B1
21	atorvastatin32 34 9 18 9	12.4	SHBG, CYP3A4, CES1, IL2RA, SLC17A5, SLCO1A2
22	n acetylcysteine32	8.3	SLC17A5, HIF1A, IL2RA, APOE, GPT, F2
23	estrone32 9 18 9	11.3	IL2RA, ESR1, ESR2, CYP1A1, CYP1B1, CYP3A4
24	ursodeoxycholic acid32 9 18 9	11.3	SLCO1A2, ABCC2, ABCB7, ABCB4, ABCB11, NR1I2
25	cholesterol32 9 18 9	11.2	GGT1, GPT, ATP8B1, CES1, NR1I2, SLC17A5
26	troglitazone32 42 9 9	11.2	ABCB11, NR1I2, CYP1A1, CYP3A4, GPT, BAX
27	etoposide32 42 9 9	10.8	BCL2, BAX, ESR2, TP53, ABCB11, ABCB4
28	vitamin d32	7.8	IL2RA, ESR2, NR1H4, NR1I2, SHBG, AHSG
29	progesterone32 42 9 18 9	11.7	NR1H4, CYP17A1, CYP1B1, ESR2, ESR1, CES1
30	lipid32	7.7	SHBG, CES1, GGT1, SLC17A5, ABCC2, ABCB7
31	indole-3-carbinol32	7.7	BCL2, BAX, ESR1, TP53, CYP1A1, CYP1B1
32	arginine32	7.6	GGT1, CYP17A1, CYP1A1, HLA-DRB1, HLA-DQA1, ESR2
33	arsenite32 18	8.6	GGT1, BCL2, HIF1A, BAX, TP53, CYP1A1
34	testosterone32 9 18 9	10.5	CES1, IL2RA, CYP17A1, HIF1A, TGFB2, SLCO1A2
35	quercetin32 42 9 18 9	11.5	GGT1, HIF1A, NR1I2, BCL2, BAX, ESR2
36	cyclosporin a32 42	8.2	GPT, APOE, IL2RA, F2, CYP3A4, SLCO1B3
37	methotrexate32 34 42 9 9	11.2	ABCC1, HIF1A, SLCO1A2, SLC17A5, SLCO1B3, ABCC2
38	docetaxel32 34 9 9	10.1	TP53, ESR1, BAX, BCL2, CYP1B1, CYP3A4
39	estrogen32	7.1	TGFB2, F2, HIF1A, ABCB4, ABCB11, SHBG
40	5fluorouracil32	7.1	CYP1B1, ESR1, IL2RA, CES1, BAX, BCL2
41	resveratrol32 9 18 9	9.9	CYP3A4, HIF1A, CYP1B1, TP53, ESR2, ESR1
42	dexamethasone32 42 34 9 9	10.8	NR1H4, CYP17A1, CYP3A4, CYP1B1, CYP1A1, HLA-G
43	paclitaxel32 34 9 9	9.6	CYP3A4, ABCB4, ABCC1, ABCC2, HIF1A, ABCB11
44	oligonucleotide32	6.5	HLA-DQA1, CES1, BCL2, HLA-G, CYP17A1, TGFB2
45	doxorubicin32 34 9 9	9.5	BAX, BCL2, HIF1A, ABCC2, ABCC1, ABCB4
46	genistein32 9 18 9	9.4	ABCC1, BAX, IL2RA, ESR1, TGFB2, EDN1
47	actinomycin d32	6.1	BAX, APOE, HIF1A, ABCC1, ABCB11, BCL2
48	cycloheximide32	5.9	EDN1, NR1I2, CYP17A1, CYP1B1, CYP1A1, TP53
49	retinoic acid32 42 18	7.9	HIF1A, TGFB2, ABCC2, ABCB11, BCL2, BAX
50	tamoxifen32 34 9 9	8.4	GGT1, SLC17A5, TGFB2, HIF1A, ABCB11, SHBG

Cellular components related to intrahepatic cholestasis of pregnancy according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	MHC class II protein complex	GO:042613	9.7	HLA-DQA1, HLA-DPA1, HLA-DRB1, HLA-DQB1
2	clathrin-coated endocytic vesicle membrane	GO:030669	9.7	HLA-DRB1, HLA-DPA1, HLA-DQB1, HLA-DQA1
3	trans-Golgi network membrane	GO:032588	9.6	HLA-DQB1, HLA-DQA1, HLA-DPA1, HLA-DRB1
4	transport vesicle membrane	GO:030658	9.5	HLA-DQA1, HLA-DPA1, HLA-DRB1, HLA-DQB1
5	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	9.5	HLA-E, HLA-G, HLA-DPA1, HLA-DQA1, HLA-DQB1, HLA-DRB1
6	ER to Golgi transport vesicle membrane	GO:012507	9.5	HLA-DPA1, HLA-DQB1, HLA-DRB1, HLA-G, HLA-E, HLA-DQA1
7	endocytic vesicle membrane	GO:030666	9.4	HLA-DQB1, HLA-DQA1, HLA-DPA1, HLA-DRB1
8	lysosomal membrane	GO:005765	9.0	HLA-DQA1, HLA-DQB1, HLA-DRB1, SLC17A5, HLA-DPA1
9	integral to plasma membrane	GO:005887	8.8	HLA-DPA1, ABCC2, ABCB4, ABCC1, HLA-DRB1, SLC17A5
10	membrane	GO:016020	7.5	SLC17A5, BCL2, ESR1, HLA-DQB1, HLA-DRB1, ABCB11
11	plasma membrane	GO:005886	6.2	SLCO1B3, SLCO1A2, ABCC2, ABCB4, ABCB11, F2

Biological processes related to intrahepatic cholestasis of pregnancy according to GeneDecks:

(show all 23)

id	Name	GO ID	Score	Top Affiliating Genes
1	organic anion transport	GO:015711	10.3	ABCC2, SLCO1A2, SLCO1B3
2	bile acid and bile salt transport	GO:015721	10.3	ATP8B1, SLCO1A2, ABCB11, SLCO1B3
3	bile acid metabolic process	GO:008206	10.2	SLCO1A2, ABCB11, NR1H4, ATP8B1, SLCO1B3
4	drug export	GO:046618	10.2	NR1I2, ABCC1
5	positive regulation of chemokine-mediated signaling pathway	GO:070101	10.0	EDN1, HIF1A
6	blood vessel remodeling	GO:001974	9.9	BAX, EPAS1, TGFB2
7	T cell costimulation	GO:031295	9.8	HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPA1
8	T cell receptor signaling pathway	GO:050852	9.7	HLA-DQA1, HLA-DRB1, HLA-DQB1, HLA-DPA1
9	interferon-gamma-mediated signaling pathway	GO:060333	9.6	HLA-DQA1, HLA-G, HLA-E, HLA-DRB1, HLA-DQB1, HLA-DPA1
10	xenobiotic metabolic process	GO:006805	9.6	CYP17A1, GGT1, CYP1B1, NR1I2, CYP3A4, CYP1A1
11	cytokine-mediated signaling pathway	GO:019221	9.6	HLA-E, HLA-DRB1, HLA-G, HLA-DQB1, HLA-DPA1, HLA-DQA1
12	regulation of nitrogen utilization	GO:006808	9.6	BAX, BCL2
13	transmembrane transport	GO:055085	9.5	ABCC1, SLC4A2, ABCC2, SLC17A5, SLCO1A2, ABCB7
14	positive regulation of nitric-oxide synthase activity	GO:051000	9.4	ESR1, APOE, HIF1A
15	response to toxin	GO:009636	9.3	BCL2, CES1, CYP1B1, BAX
16	antigen processing and presentation of exogenous peptide antigen via MHC class II	GO:019886	9.2	HLA-DPA1, HLA-DQB1, HLA-DRB1, HLA-DQA1
17	release of cytochrome c from mitochondria	GO:001836	8.9	TP53, BAX, BCL2
18	neuron apoptotic process	GO:051402	8.9	BCL2, TP53, BAX
19	response to drug	GO:042493	8.8	ABCC1, EDN1, ABCB4, CYP17A1, BCL2, TGFB2
20	response to hypoxia	GO:001666	8.8	BCL2, EPAS1, HIF1A, TGFB2, EDN1
21	response to gamma radiation	GO:010332	8.8	TP53, BAX, BCL2
22	negative regulation of cell growth	GO:030308	8.7	ESR2, AHSG, BCL2, TP53, TGFB2
23	small molecule metabolic process	GO:044281	8.5	ABCB4, GPT, CYP1A1, CYP1B1, GGT1, CYP3A4

Molecular functions related to intrahepatic cholestasis of pregnancy according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	organic anion transmembrane transporter activity	GO:008514	10.1	SLCO1A2, ABCC2, SLCO1B3
2	oxygen binding	GO:019825	9.8	CYP1B1, CYP17A1, CYP3A4, CYP1A1
3	MHC class II receptor activity	GO:032395	9.7	HLA-DQA1, HLA-DQB1, HLA-DPA1, HLA-DRB1
4	vitamin D 24-hydroxylase activity	GO:070576	9.7	CYP1A1, CYP3A4
5	histone acetyltransferase binding	GO:035035	9.4	TP53, HIF1A, EPAS1
6	steroid binding	GO:005496	9.2	ESR2, CYP3A4, ESR1
7	steroid hormone receptor activity	GO:003707	9.2	ESR1, ESR2, NR1H4, NR1I2
8	protein heterodimerization activity	GO:046982	7.8	EPAS1, BCL2, TGFB2, TP53, HIF1A, BAX