ICP
MCID: INT099
MIFTS: 37

Intrahepatic Cholestasis of Pregnancy (ICP) malady

Reproductive, Genetic categories

Summaries for Intrahepatic Cholestasis of Pregnancy

Sources:
21Genetics Home Reference, 64Wikipedia, 33MalaCards
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Genetics Home Reference:21 Intrahepatic cholestasis of pregnancy is a liver disorder that occurs in pregnant women. Cholestasis is a condition that impairs the release of a digestive fluid called bile from liver cells. As a result, bile builds up in the liver, impairing liver function. Because the problems with bile release occur within the liver (intrahepatic), the condition is described as intrahepatic cholestasis. Intrahepatic cholestasis of pregnancy usually becomes apparent in the third trimester of pregnancy. Bile flow returns to normal after delivery of the baby, and the signs and symptoms of the condition disappear. However, they can return during later pregnancies.

MalaCards: Intrahepatic Cholestasis of Pregnancy, also known as familial intrahepatic cholestasis of pregnancy, is related to intrahepatic cholestasis and hepatitis c. An important gene associated with Intrahepatic Cholestasis of Pregnancy is ABCB4 (ATP-binding cassette, sub-family B (MDR/TAP), member 4), and among its related pathways are Pravastatin Pathway, Pharmacokinetics and Endosomal/Vacuolar pathway. The compounds wort and bromosulfophthalein have been mentioned in the context of this disorder. Affiliated tissues include liver, and related mouse phenotypes are liver/biliary system and immune system.

Wikipedia:64 Intrahepatic cholestasis of pregnancy (ICP), termed obstetric cholestasis in the United Kingdom, (also... more...

Aliases & Classifications for Intrahepatic Cholestasis of Pregnancy

Sources:
43NIH Rare Diseases, 21Genetics Home Reference, 20GeneTests, 61UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic
Anatomical: Reproductive


Aliases & Descriptions:

intrahepatic cholestasis of pregnancy 43 21
familial intrahepatic cholestasis of pregnancy 43 20
familial recurrent intrahepatic cholestasis of pregnancy 43
recurrent intrahepatic cholestasis of pregnancy 21
cholestasis, intrahepatic of pregnancy 43
progressive intrahepatic cholestasis 61
pregnancy related cholestasis 43
pregnancy-related cholestasis 21
cholestasis of pregnancy 61
obstetric cholestasis 21
icp 43


Related Diseases for Intrahepatic Cholestasis of Pregnancy

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the cholestasis, intrahepatic, of pregnancy, 1 family:

intrahepatic cholestasis of pregnancy cholestasis, intrahepatic, of pregnancy, 3

Diseases related to Intrahepatic Cholestasis of Pregnancy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 94)
idRelated DiseaseScoreTop Affiliating Genes
1intrahepatic cholestasis32.2ABCC2, ABCB11, ABCB4, GGT1, NR1I2, ATP8B1
2hepatitis c30.7IL12B, GPT, ABCC2, ABCB7, GGT1, ABCB4
3benign recurrent intrahepatic cholestasis30.6ABCB11, ATP8B1
4viral hepatitis30.6GGT1, ABCB7, GPT
5choledocholithiasis30.4GPT, GGT1
6hepatitis b30.4IL12B, ABCB7, GPT, GGT1
7low gamma-gt familial intrahepatic cholestasis30.3ATP8B1, ABCB11
8cholestasis, progressive familial intrahepatic 330.3ATP8B1, ABCB11, ABCB4
9cholestasis, progressive familial intrahepatic 130.3GGT1, ATP8B1, ABCB11, ABCB4, NR1H4
10fatty liver disease30.1GGT1
11cholelithiasis30.1GPT, ABCB11, ABCB4, GGT1
12cholestasis, intrahepatic, of pregnancy, 110.6
13eclampsia10.4
14hepatitis d10.4
15n syndrome10.4
16normal pressure hydrocephalus10.3
17impetigo herpetiformis10.3
18steatorrhea10.3
19gestational diabetes10.3
20drug-induced hepatitis10.3
21hypoxia10.3
22hepatitis c virus10.3
23cholestasis, intrahepatic, of pregnancy, 310.3
24estrogen resistance10.2
25intracranial aneurysm10.2
26brain injury10.2
27head injury10.2
28pregnancy loss, recurrent 110.2
29brain compression10.1
30cerebral aneurysms10.1
31lip disease10.1
32primary biliary cirrhosis10.0SLC4A2
33arthritis10.0ESR2
34myocardial infarction10.0ABCB7
35severe pre-eclampsia10.0HLA-G
36pancreatitis10.0ABCB4, GGT1
37hypertension10.0GGT1
38colon cancer10.0ESR2
39cholestasis, progressive familial intrahepatic 210.0ABCB4, ABCB11, ATP8B1
40acute pancreatitis10.0GPT, ABCB7
41alagille syndrome10.0ATP8B1, ABCB4
42celiac disease10.0HLA-DPA1, HLA-G
43malaria10.0IL12B
44leukopenia10.0ABCB7, GPT, HLA-G
45myeloma10.0HLA-G, HLA-E
46infertility10.0HLA-G, ESR2, AHSG
47substance abuse10.0GGT1
48cholangitis10.0GGT1, GPT, ABCB4
49sarcoma10.0ABCB11
50cerebrotendinous xanthomatosis10.0NR1I2, NR1H4

Graphical network of the top 20 diseases related to Intrahepatic Cholestasis of Pregnancy:



Diseases related to intrahepatic cholestasis of pregnancy

Clinical Features for Intrahepatic Cholestasis of Pregnancy

Drugs & Therapeutics for Intrahepatic Cholestasis of Pregnancy

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Intrahepatic Cholestasis of Pregnancy

Drug clinical trials:

Search ClinicalTrials for Intrahepatic Cholestasis of Pregnancy

Search NIH Clinical Center for Intrahepatic Cholestasis of Pregnancy

Search CenterWatch for Intrahepatic Cholestasis of Pregnancy

Genetic Tests for Intrahepatic Cholestasis of Pregnancy

Sources:
20GeneTests
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Genetic tests related to Intrahepatic Cholestasis of Pregnancy:

id Genetic test Affiliating Genes
1 Cholestasis, Familial Intrahepatic, Of Pregnancy20 ABCB4

Anatomical Context for Intrahepatic Cholestasis of Pregnancy

Sources:
33MalaCards
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MalaCards organs/tissues related to Intrahepatic Cholestasis of Pregnancy:

33
Liver

Animal Models for Intrahepatic Cholestasis of Pregnancy or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Intrahepatic Cholestasis of Pregnancy:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053709.4ESR2, ABCB4, ABCB11, ABCC2, NR1H4, NR1I2
2MP:00053879.3LAP3, GGT1, SLCO1A2, SLC4A2, ABCB4, IL12B
3MP:00053768.7ABCC2, SLC4A2, ABCB4, ABCB7, ABCB11, ATP8B1

Publications for Intrahepatic Cholestasis of Pregnancy

Genetic Variations for Intrahepatic Cholestasis of Pregnancy

Expression for genes affiliated with Intrahepatic Cholestasis of Pregnancy

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Intrahepatic Cholestasis of Pregnancy

Search GEO for disease gene expression data for Intrahepatic Cholestasis of Pregnancy.

Pathways for genes affiliated with Intrahepatic Cholestasis of Pregnancy

Sources:
50PharmGKB, 54Reactome, 38NCBI BioSystems Database, 12EMD Millipore, 52QIAGEN, 30KEGG
See all sources

Pathways related to Intrahepatic Cholestasis of Pregnancy according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3ABCB11, ABCC2
210.3HLA-E, HLA-G
3
Hide members
10.2NR1H4, ESR2, NR1I2
410.2SLC4A2, NR1I2, NR1H4
510.1ABCB4, ABCC2, ABCB11, SLCO1A2
610.1ABCC2, NR1I2, NR1H4, ABCB11
7
Hide members
10.1ABCC2, ABCB11, ABCB7, ABCB4
8
Hide members
10.0CES1, ABCC2, CYP1B1, NR1I2
910.0NR1I2, NR1H4, ABCC2, ABCB4, ABCB11
10
Hide members
10.0HLA-DPA1, HLA-E, HLA-G, IL12B
11
Hide members
10.0HLA-DPA1, IL12B, HLA-G, HLA-E
12
Hide members
9.9ATP8B1, ABCC2, ABCB7, SLC4A2, SLCO1A2
139.9SLC4A2, SLCO1A2, ABCB4, ABCB11, ABCC2, NR1H4
14
Hide members
9.6SLCO1A2, GPT, GGT1, LAP3, CES1, ABCB11

Compounds for genes affiliated with Intrahepatic Cholestasis of Pregnancy

Sources:
45Novoseek, 29IUPHAR, 24HMDB, 60Tocris Bioscience, 50PharmGKB, 11DrugBank, 2BitterDB
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Compounds related to Intrahepatic Cholestasis of Pregnancy according to GeneCards/GeneDecks:

(show top 50)    (show all 135)
idCompoundScoreTop Affiliating Genes
1wort4510.5NR1I2, ABCB11, ABCC2
2bromosulfophthalein4510.5GPT, ABCC2, SLCO1A2
3lithocholic acid45 29 2412.5NR1I2, ABCB11, SLCO1A2, NR1H4
4glycocholate4510.5ABCB4, ABCB11, ABCC2, GPT
5gw 406445 6011.5NR1I2, ABCC2, NR1H4
6ethinyl estradiol50 1111.5ABCC2, ABCB11, NR1I2
7rifampin50 1111.5ABCC2, ABCB11, SLCO1A2, NR1I2
8paclitaxel45 50 1112.5ABCC2, IL12B, CYP1B1
9estrogen4510.4CES1, ABCB4, ABCC2, AHSG
10digoxin45 50 60 11 2414.4NR1I2, ABCC2, ABCB11, SLCO1A2
11rosuvastatin45 50 29 1113.4ABCC2, ABCB11, SLCO1A2, GPT
12flavonoid4510.4CES1, ABCC2, LAP3, CYP1B1
13ketoconazole45 29 11 2413.4SLCO1A2, ABCC2, CYP1B1, NR1I2, ABCB11
14taurocholate4510.4ABCB11, ATP8B1, NR1H4, ABCB4, SLCO1A2, ABCC2
15ritonavir45 50 1112.4SLCO1A2, ABCB11, ABCC2, NR1I2
16cholic acid45 29 11 2413.3ABCC2, NR1H4, SLCO1A2, CES1, NR1I2, ABCB11
17glucose4510.3NR1I2, LAP3, NR1H4, ABCB11, AHSG
18pravastatin45 50 29 11 2414.3CES1, SLCO1A2, ABCB11, ABCC2, GPT, ABCB7
19phenytoin45 50 29 1113.3ABCC2, ABCB11, NR1I2, GGT1
20mycophenolate mofetil45 50 1112.3CES1, GGT1, ABCC2, GPT
21phosphorus4510.3LAP3, GPT, GGT1, ABCB7
22vitamin-e4510.3GPT, ABCB7, NR1I2, CES1, GGT1
23rifampicin45 29 6012.3SLCO1A2, ABCC2, NR1I2, ABCB11, GGT1, GPT
24daunorubicin45 50 1112.3ABCC2, CYP1B1, ABCB4, ABCB11
25dexamethasone45 50 29 1113.2NR1I2, GGT1, ABCC2, ABCB4, SLCO1A2, CYP1B1
26verapamil45 50 29 11 2414.2ABCB11, GGT1, GPT, ABCC2, SLCO1A2, ABCB4
27chenodeoxycholic acid45 29 11 2413.2GPT, NR1I2, ABCC2, NR1H4, SLCO1A2, ABCB4
28tacrolimus45 50 1112.2GPT, GGT1, ABCB4, ABCB11, ABCC2, NR1I2
29phenobarbital45 29 1112.2NR1I2, ABCB11, CYP1B1, GGT1, GPT, ABCC2
30lovastatin45 50 60 29 1114.2ABCC2, GPT, NR1I2, GGT1, CES1, SLCO1A2
31urea45 11 2412.2HLA-G, GPT, ABCC2, CES1, ABCB7, GGT1
32cyclosporine50 1111.2ABCB11, ABCC2, SLCO1A2
33methotrexate45 50 1112.2HLA-G, GPT, ABCC2, ABCB4, SLCO1A2, GGT1
34vitamin d4510.1NR1H4, NR1I2, ESR2, GPT, IL12B, AHSG
35quercetin45 60 11 2413.1ABCC2, GGT1, ESR2, NR1I2, CYP1B1
36acetaminophen45 2 50 11 2414.1GGT1, NR1I2, GPT, ABCC2
37rhodamine 12345 5011.1ABCC2, ABCB11, ABCB4
38tamoxifen45 50 29 1113.1CYP1B1, CES1, ESR2, GGT1, ABCB11, NR1I2
39doxorubicin45 50 1112.1ABCC2, NR1I2, ABCB11, CYP1B1, ABCB4, ESR2
40chloride4510.1ABCB11, SLC4A2, ABCB7, GPT, ABCC2
41arsenite45 2411.1SLC4A2, NR1I2, CYP1B1, ABCC2, GGT1
42ethanol45 50 11 2413.0CES1, LAP3, GGT1, ABCB7, GPT, AHSG
43ursodeoxycholic acid45 11 2412.0ABCB4, SLCO1A2, GGT1, NR1H4, NR1I2, GPT
44progesterone45 60 29 11 2414.0HLA-G, ABCC2, CES1, ESR2, ABCB7, ABCB11
45testosterone45 60 11 2413.0NR1H4, CYP1B1, ABCB7, NR1I2, SLCO1A2, CES1
46sodium45 2410.9NR1H4, ABCB7, HLA-G, ABCC2, GPT, SLC4A2
47cholesterol45 29 11 2412.8ATP8B1, ABCB4, GPT, NR1I2, ABCB7, SLCO1A2
48nevirapine45 50 1111.8GPT, ABCB7, GGT1
49creatinine459.8GGT1, LAP3, ABCC2, GPT, HLA-G, ABCB7
50lipid459.4ABCB4, CYP1B1, HLA-G, ABCB11, GGT1, NR1H4

GO Terms for genes affiliated with Intrahepatic Cholestasis of Pregnancy

Sources:
16Gene Ontology
See all sources

Cellular components related to Intrahepatic Cholestasis of Pregnancy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intercellular canaliculusGO:04658110.4ABCB4, ABCB11, ABCC2
2integral to lumenal side of endoplasmic reticulum membraneGO:07155610.2HLA-G, HLA-E, HLA-DPA1
3ER to Golgi transport vesicle membraneGO:01250710.2HLA-DPA1, HLA-E, HLA-G
4apical plasma membraneGO:01632410.0ATP8B1, ABCC2, ABCB11, ABCB4
5MHC class I protein complexGO:04261210.0HLA-G, HLA-E
6Golgi membraneGO:00013910.0ABCB4, ABCB11, HLA-G, HLA-E, HLA-DPA1
7plasma membraneGO:0058869.4HLA-E, HLA-G, ATP8B1, ABCC2, ABCB11, ABCB4

Biological processes related to Intrahepatic Cholestasis of Pregnancy according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1bile acid and bile salt transportGO:01572110.3ATP8B1, ABCB11, SLCO1A2
2bile acid metabolic processGO:00820610.3SLCO1A2, ATP8B1, NR1H4, ABCB11
3positive regulation of T cell mediated cytotoxicityGO:00191610.2HLA-E, HLA-G, IL12B
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independentGO:00248010.2HLA-G, HLA-E
5interferon-gamma-mediated signaling pathwayGO:06033310.1HLA-E, HLA-G, HLA-DPA1
6transportGO:00681010.1ABCB11, ABCB7, ABCB4, ABCC2
7transmembrane transportGO:0550859.9SLC4A2, ABCB4, SLCO1A2, ABCB7, ABCB11, ABCC2
8small molecule metabolic processGO:0442819.4ABCB7, GGT1, SLCO1A2, ABCB4, CYP1B1, GPT

Molecular functions related to Intrahepatic Cholestasis of Pregnancy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1organic anion transmembrane transporter activityGO:00851410.3SLCO1A2, ABCC2
2ATPase activity, coupled to transmembrane movement of substancesGO:04262610.1ABCB4, ABCB7, ABCB11, ABCC2
3ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityGO:00487910.1NR1I2, NR1H4, ESR2
4steroid hormone receptor activityGO:0037079.9ESR2, NR1H4, NR1I2

Products for genes affiliated with Intrahepatic Cholestasis of Pregnancy

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Sources for Intrahepatic Cholestasis of Pregnancy

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet