ICP
MCID: INT099
MIFTS: 49

Intrahepatic Cholestasis of Pregnancy (ICP) malady

Genetic diseases, Rare diseases, Reproductive diseases, Liver diseases categories

Summaries for Intrahepatic Cholestasis of Pregnancy

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66Wikipedia, 34MalaCards
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Wikipedia:66 Intrahepatic cholestasis of pregnancy (ICP), also known as obstetric cholestasis, cholestasis of... more...

MalaCards: Intrahepatic Cholestasis of Pregnancy, also known as recurrent intrahepatic cholestasis of pregnancy, is related to cholestasis and intrahepatic cholestasis. An important gene associated with Intrahepatic Cholestasis of Pregnancy is ABCB4 (ATP-binding cassette, sub-family B (MDR/TAP), member 4), and among its related pathways are Statin Pathway - Generalized, Pharmacokinetics and ABC-family proteins mediated transport. The compounds fusidic acid and gf 120918 have been mentioned in the context of this disorder. Affiliated tissues include placenta, liver and testes, and related mouse phenotypes are liver/biliary system and homeostasis/metabolism.

Aliases & Classifications for Intrahepatic Cholestasis of Pregnancy

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44NIH Rare Diseases, 22Genetics Home Reference, 21GeneTests, 63UMLS
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Classifications:



Aliases & Descriptions:

intrahepatic cholestasis of pregnancy 44 22
recurrent intrahepatic cholestasis of pregnancy 44 22
familial intrahepatic cholestasis of pregnancy 44 21
familial recurrent intrahepatic cholestasis of pregnancy 44
cholestasis, intrahepatic of pregnancy 44
progressive intrahepatic cholestasis 63
pregnancy related cholestasis 44
pregnancy-related cholestasis 22
cholestasis of pregnancy 63
obstetric cholestasis 22
ricp 44
icp 44


Related Diseases for Intrahepatic Cholestasis of Pregnancy

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18GeneCards, 19GeneDecks
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Diseases in the Cholestasis, Intrahepatic, of Pregnancy, 1 family:

intrahepatic cholestasis of pregnancy Cholestasis, Intrahepatic, of Pregnancy, 3

Diseases related to Intrahepatic Cholestasis of Pregnancy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 63)
idRelated DiseaseScoreTop Affiliating Genes
1cholestasis32.0ABCB11, ABCB4, NR1H4, NR1I3, ABCC2
2intrahepatic cholestasis32.0ABCB11, ABCB4, NR1H4, HLA-G, NR1I3, ABCC2
3breast cancer30.1ABCB4, NR1H4, ABCB11, ABCC2, HLA-G, NR1I3
4hepatitis10.6
5cholestasis, intrahepatic, of pregnancy, 110.6
6eclampsia10.4
7pre-eclampsia10.4
8viral hepatitis10.4
9benign recurrent intrahepatic cholestasis10.4
10hydrocephalus10.4
11cerebritis10.3
12intracranial hypertension10.3
13choledocholithiasis10.3
14steatorrhea10.3
15gestational diabetes10.3
16impetigo herpetiformis10.3
17diabetes mellitus10.3
18impetigo10.3
19liver disease10.3
20acute fatty liver of pregnancy10.3
21hypoxia10.3
22cholestasis, intrahepatic, of pregnancy, 310.3
23blindness10.3
24aneurysm10.3
25head injury10.2
26normal pressure hydrocephalus10.1
27brain compression10.1
28communicating hydrocephalus10.1
29brain injury10.1
30cerebral aneurysms10.1
31cholangitis10.1ABCB4
32cholestasis, progressive familial intrahepatic 210.1ABCB4, ABCB11
33cholestasis, progressive familial intrahepatic 310.1ABCB4, ABCB11
34cholelithiasis10.1ABCB4, ABCB11
35primary sclerosing cholangitis10.0ABCB4, ABCC2
36hepatitis c10.0ABCB4, ABCC2
37hepatoblastoma10.0ABCC2, NR1H4
38b-cell chronic lymphocytic leukemia10.0HLA-G, ABCB4
39cholestasis, progressive familial intrahepatic 110.0ABCB4, ABCB11, NR1H4
40galactosemia10.0ABCB11, ABCB4, NR1H4
41acute leukemia10.0HLA-G, ABCB4, ABCC2
42endometriosis10.0AHSG, HLA-G
43bilirubin metabolic disorder10.0NR1I3, ABCC2
44ovarian cancer10.0ABCB11, ABCC2, HLA-G
45uremia10.0AHSG, NR1I3
46ipex syndrome10.0ABCB11, ABCC2, HLA-G
47malignant glioma10.0ABCB4, ABCC2, HLA-G
48intracranial aneurysm10.0
49arachnoiditis10.0
50brain edema10.0

Graphical network of the top 20 diseases related to Intrahepatic Cholestasis of Pregnancy:



Diseases related to intrahepatic cholestasis of pregnancy

Symptoms for Intrahepatic Cholestasis of Pregnancy

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Drugs & Therapeutics for Intrahepatic Cholestasis of Pregnancy

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Intrahepatic Cholestasis of Pregnancy

Drug clinical trials:

Search ClinicalTrials for Intrahepatic Cholestasis of Pregnancy

Search NIH Clinical Center for Intrahepatic Cholestasis of Pregnancy

Search CenterWatch for Intrahepatic Cholestasis of Pregnancy

Genetic Tests for Intrahepatic Cholestasis of Pregnancy

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21GeneTests
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Genetic tests related to Intrahepatic Cholestasis of Pregnancy:

id Genetic test Affiliating Genes
1 Cholestasis, Familial Intrahepatic, of Pregnancy21 ABCB4

Anatomical Context for Intrahepatic Cholestasis of Pregnancy

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34MalaCards
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MalaCards organs/tissues related to Intrahepatic Cholestasis of Pregnancy:

34
Placenta, Liver, Testes, Smooth muscle, Breast

Animal Models for Intrahepatic Cholestasis of Pregnancy or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Intrahepatic Cholestasis of Pregnancy:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053707.8NR1H4, NR1I3, ABCC2, ABCB11, ABCB4
2MP:00053766.4NR1H4, ABCB4, ABCB11, ABCC2, HLA-G, AHSG

Publications for Intrahepatic Cholestasis of Pregnancy

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53PubMed
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Articles related to Intrahepatic Cholestasis of Pregnancy:

(show top 50)    (show all 258)
idTitleAuthorsYear
1
Ursodeoxycholic acid in the treatment of intrahepatic cholestasis of pregnancy: a randomized controlled trial. (23978872)
2013
2
Primary bile acids as potential biomarkers for the clinical grading of intrahepatic cholestasis of pregnancy. (23562588)
2013
3
Study on the regulation of cell adhesion molecule expression and function in placenta from women with intrahepatic cholestasis of pregnancy. (23810461)
2013
4
Menopause after a history of intrahepatic cholestasis of pregnancy. (24149924)
2013
5
Intrahepatic cholestasis of pregnancy: correlation of preterm delivery with bile acids. (22287405)
2011
6
Pregnancy outcome in cases of intrahepatic cholestasis of pregnancy. (21247575)
2011
7
Bile acid signaling in fetal tissues: implications for intrahepatic cholestasis of pregnancy. (21691106)
2011
8
Relationship between umbilical artery Doppler waveform analysis and perinatal prognosis in women with intrahepatic cholestasis of pregnancy. (20705289)
2010
9
High mean platelet volume, low-grade systemic coagulation, and fibrinolytic activation are associated with pre-term delivery and low APGAR score in intrahepatic cholestasis of pregnancy. (20670095)
2010
10
Expression of HLA-G protein in placental tissues and its influence on Th1/Th2 cytokines in peripheral blood in patients with intrahepatic cholestasis of pregnancy]. (20360645)
2010
11
The influence of common gene variants of the xenobiotic receptor (PXR) in genetic susceptibility to intrahepatic cholestasis of pregnancy. (19958310)
2010
12
The c.504T>C (p.Asn168Asn) polymorphism in the ABCB4 gene as a predisposing factor for intrahepatic cholestasis of pregnancy in Greece. (19840247)
2010
13
Combined functional variants of hepatobiliary transporters and FXR aggravate intrahepatic cholestasis of pregnancy. (19490418)
2009
14
Contribution of variant alleles of ABCB11 to susceptibility to intrahepatic cholestasis of pregnancy. (18987030)
2009
15
Hepatobiliary phospholipid transporter ABCB4, MDR3 gene variants in a large cohort of Italian women with intrahepatic cholestasis of pregnancy. (18083082)
2008
16
Association of gene polymorphisms of CYP1B1 with intrahepatic cholestasis of pregnancy]. (18575334)
2008
17
Intrahepatic cholestasis of pregnancy in women with a multiple pregnancy: an analysis of risks and pregnancy outcomes. (19126282)
2008
18
Relationship of the occurrence of fetal distress and change of umbilical cord and expression of vasoactive substance in umbilical vein in intrahepatic cholestasis of pregnancy]. (18683743)
2008
19
Intrahepatic cholestasis of pregnancy: Amelioration of pruritus by UDCA is associated with decreased progesterone disulphates in urine. (17968976)
2008
20
Linkage between a new splicing site mutation in the MDR3 alias ABCB4 gene and intrahepatic cholestasis of pregnancy. (17187437)
2007
21
The importance of serum bile acid level analysis and treatment with ursodeoxycholic acid in intrahepatic cholestasis of pregnancy: a case series from central Europe. (17576942)
2007
22
Association between polymorphisms of CYP17 and CYP3A4 genes and intrahepatic cholestasis of pregnancy in Chengdu]. (16909599)
2006
23
Potential role of trans-inhibition of the bile salt export pump by progesterone metabolites in the etiopathogenesis of intrahepatic cholestasis of pregnancy. (16458994)
2006
24
Plasma lipid profiles of women with intrahepatic cholestasis of pregnancy. (16394047)
2006
25
Intrahepatic cholestasis of pregnancy as an indicator of liver and biliary diseases: a population-based study. (16557542)
2006
26
Intrahepatic cholestasis of pregnancy: Relationships between bile acid levels and fetal complication rates. (15368452)
2004
27
Diagnosis and therapy of intrahepatic cholestasis of pregnancy. (15248112)
2004
28
A second heterozygous MDR3 nonsense mutation associated with intrahepatic cholestasis of pregnancy. (12624161)
2003
29
ABCB4 gene sequence variation in women with intrahepatic cholestasis of pregnancy. (12746424)
2003
30
Intrahepatic cholestasis of pregnancy: review of the literature. (11773831)
2002
31
Intrahepatic cholestasis of pregnancy: what's new. (12224684)
2002
32
Ursodeoxycholic acid for the treatment of intrahepatic cholestasis of pregnancy. (11392594)
2001
33
Oral guar gum, a gel-forming dietary fiber relieves pruritus in intrahepatic cholestasis of pregnancy. (10746839)
2000
34
Intrahepatic cholestasis of pregnancy has no effect on maternal serum second trimester alpha-fetoprotein and hCG. (10929953)
2000
35
Apolipoprotein E alleles in women with intrahepatic cholestasis of pregnancy. (11063158)
2000
36
Bile acids and progesterone metabolites in intrahepatic cholestasis of pregnancy. (10766400)
2000
37
Intrahepatic cholestasis of pregnancy: a critical review. (11249293)
2000
38
Hepatitis G virus infection detected in a woman with intrahepatic cholestasis of pregnancy. (9890225)
1998
39
A randomised placebo-controlled trial of ursodeoxycholic acid and S-adenosylmethionine in the treatment of intrahepatic cholestasis of pregnancy. (9853771)
1998
40
Intrahepatic cholestasis of pregnancy. (9638904)
1998
41
Severe fetal intracranial haemorrhage during treatment with cholestyramine for intrahepatic cholestasis of pregnancy. (7756215)
1995
42
Serum conjugated bile acid profile during intrahepatic cholestasis of pregnancy. (7751589)
1995
43
Intrahepatic cholestasis of pregnancy. (7888831)
1994
44
Intrahepatic cholestasis of pregnancy: a retrospective case-control study of perinatal outcome. (8141222)
1994
45
Ursodeoxycholic acid treatment of intrahepatic cholestasis of pregnancy: observations on efficacy and safety. (8425713)
1993
46
Epomediol ameliorates pruritus in patients with intrahepatic cholestasis of pregnancy. (1484159)
1992
47
Intrahepatic cholestasis of pregnancy and acute fatty liver of pregnancy. An unusual but favorable association? (2001812)
1991
48
Serum copper in intrahepatic cholestasis of pregnancy. (1820694)
1991
49
S-adenosylmethionine for the treatment of intrahepatic cholestasis of pregnancy. Results of a controlled clinical trial. (2083923)
1990
50
Familial recurrent intrahepatic cholestasis of pregnancy: a genetic study providing evidence for transmission of a sex-limited, dominant trait. (6852450)
1983

Variations for Intrahepatic Cholestasis of Pregnancy

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1 National Center for Biotechnology Information (Clinvar)
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Clinvar genetic disease variations for Intrahepatic Cholestasis of Pregnancy:

1 (show all 12)
id Gene Name Type Significance SNP ID Assembly Location
1ATP8B1NM_005603.4(ATP8B1): c.1993G> T (p.Glu665Ter)single nucleotide variantPathogenicrs515726137GRCh37Chr 18, 55336654: 55336654
2ATP8B1NM_005603.4(ATP8B1): c.625C> A (p.Pro209Thr)single nucleotide variantPathogenicrs515726138GRCh38Chr 18, 57697797: 57697797
3ATP8B1NM_005603.4(ATP8B1): c.923G> T (p.Gly308Val)single nucleotide variantPathogenicrs111033609GRCh37Chr 18, 55362420: 55362420
4NM_005603.4(ATP8B1): c.2674G> A (p.Gly892Arg)single nucleotide variantPathogenicrs121909098GRCh37Chr 18, 55328439: 55328439
5ATP8B1NM_005603.4(ATP8B1): c.863T> C (p.Leu288Ser)single nucleotide variantPathogenicrs121909099GRCh37Chr 18, 55362480: 55362480
6ATP8B1NM_005603.4(ATP8B1): c.2097+2T> Csingle nucleotide variantPathogenicrs387906381GRCh37Chr 18, 55336548: 55336548
7ATP8B1NM_005603.4(ATP8B1): c.1982T> C (p.Ile661Thr)single nucleotide variantPathogenicrs121909100GRCh37Chr 18, 55336665: 55336665
8ATP8B1NM_005603.4(ATP8B1): c.1660G> A (p.Asp554Asn)single nucleotide variantPathogenicrs121909101GRCh37Chr 18, 55342225: 55342225
9ATP8B1NM_005603.4(ATP8B1): c.208G> A (p.Asp70Asn)single nucleotide variantPathogenicrs34719006GRCh37Chr 18, 55373793: 55373793
10NM_005603.4(ATP8B1): c.2599C> T (p.Arg867Cys)single nucleotide variantPathogenicrs121909103GRCh37Chr 18, 55328514: 55328514
11ATP8B1NM_005603.4(ATP8B1): c.1367C> T (p.Thr456Met)single nucleotide variantPathogenicrs121909104GRCh37Chr 18, 55355593: 55355593
12ATP8B1NM_005603.4(ATP8B1): c.1804C> T (p.Arg602Ter)single nucleotide variantPathogenicrs121909105GRCh37Chr 18, 55342081: 55342081

Expression for genes affiliated with Intrahepatic Cholestasis of Pregnancy

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Intrahepatic Cholestasis of Pregnancy

Search GEO for disease gene expression data for Intrahepatic Cholestasis of Pregnancy.

Pathways for genes affiliated with Intrahepatic Cholestasis of Pregnancy

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51PathCards, 52PharmGKB, 56Reactome, 31KEGG, 54QIAGEN, 39NCBI BioSystems Database
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Compounds for genes affiliated with Intrahepatic Cholestasis of Pregnancy

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46Novoseek, 12DrugBank, 52PharmGKB, 30IUPHAR, 62Tocris Bioscience, 25HMDB, 3BitterDB
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Compounds related to Intrahepatic Cholestasis of Pregnancy according to GeneCards/GeneDecks:

(show top 50)    (show all 74)
idCompoundScoreTop Affiliating Genes
1fusidic acid46 1211.0ABCC2, ABCB11
2gf 120918469.9ABCB11, ABCC2
3psc-833469.9ABCB11, ABCC2
4ly335979469.9ABCB11, ABCC2
5estradiol-17beta-glucuronide469.9ABCC2, ABCB4
6wort469.9ABCB11, ABCC2
7pluronic f127469.9ABCB11, ABCC2
8ethinyl estradiol52 1210.8ABCC2, ABCB11
9reserpine46 30 1211.8ABCB11, ABCC2
10gw 406462 4610.8NR1H4, ABCC2
11Taurocholic acid25 1210.7ABCC2, ABCB11
12cyclosporine52 1210.7ABCC2, ABCB11
13rifampin52 1210.7ABCB11, ABCC2
14glycocholate469.6ABCB4, ABCB11, ABCC2
15rhodamine 12346 5210.6ABCC2, ABCB11, ABCB4
16daunorubicin46 52 1211.6ABCB4, ABCB11, ABCC2
17vincristine46 52 1211.5ABCC2, ABCB11, ABCB4
18verapamil46 30 52 25 1213.5ABCB4, ABCB11, ABCC2
19adriamycin469.5ABCC2, ABCB11, ABCB4
20hyperforin30 46 1211.5ABCC2, NR1I3
21tacrolimus46 52 1211.5ABCC2, ABCB11, ABCB4
22saquinavir46 1210.4ABCC2, ABCB11
23cholic acid46 30 25 1212.4ABCB11, ABCC2, NR1H4
24etoposide46 52 62 1212.4ABCB4, ABCB11, ABCC2
25methotrexate52 46 1211.4HLA-G, ABCC2, ABCB4
26colchicine46 62 3 30 1213.3NR1I3, ABCB11, ABCB4
27deoxycholic acid46 30 25 1212.2NR1H4, ABCB11
28phospholipid469.2ABCB4, ABCB11, NR1H4
29lithocholic acid46 30 2511.2ABCB11, NR1I3, NR1H4
30phenytoin46 52 30 1212.1NR1I3, ABCC2, ABCB11
31steroidal469.1NR1H4, NR1I3
32rifampicin46 30 6211.1ABCB11, ABCC2, NR1I3
33phenobarbital46 30 52 1212.1NR1I3, ABCC2, ABCB11
34taurocholate469.1ABCB4, ABCB11, ABCC2, NR1H4
35ursodeoxycholic acid46 25 1211.1ABCB4, ABCB11, ABCC2, NR1H4
36androstane469.0NR1H4, NR1I3, ABCC2
37ribonucleic acid469.0NR1I3, HLA-G, ABCB11
38paclitaxel46 52 1210.8ABCB4, ABCB11, ABCC2, NR1I3
39cyclosporin a46 30 6210.7NR1I3, ABCC2, ABCB11, ABCB4
40oligonucleotide468.7NR1I3, HLA-G, ABCB11, ABCB4
41vitamin d468.6NR1H4, NR1I3, AHSG
42sodium46 259.5ABCC2, HLA-G, NR1I3, NR1H4
43retinoic acid46 259.4ABCB11, ABCC2, NR1I3, NR1H4
44cholesterol46 30 25 1211.3ABCB4, ABCB11, HLA-G, NR1I3, NR1H4
45chenodeoxycholic acid46 30 25 1211.3NR1H4, NR1I3, ABCC2, ABCB11, ABCB4
46progesterone46 30 62 25 1212.2NR1H4, NR1I3, HLA-G, ABCC2, ABCB11
47tyrosine467.9ABCB11, ABCC2, AHSG, NR1I3, NR1H4
48dexamethasone46 52 30 1210.8NR1H4, NR1I3, HLA-G, ABCC2, ABCB11, ABCB4
49lipid467.8ABCB4, ABCB11, ABCC2, HLA-G, NR1I3, NR1H4
50estrogen467.6ABCB4, ABCB11, ABCC2, AHSG, NR1I3, NR1H4

GO Terms for genes affiliated with Intrahepatic Cholestasis of Pregnancy

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17Gene Ontology
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Cellular components related to Intrahepatic Cholestasis of Pregnancy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi membraneGO:0001399.2HLA-G, ABCB11, ABCB4
2intercellular canaliculusGO:0465819.1ABCC2, ABCB11, ABCB4
3apical plasma membraneGO:0163248.9ABCC2, ABCB11, ABCB4

Biological processes related to Intrahepatic Cholestasis of Pregnancy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1bile acid metabolic processGO:0082069.2ABCB11, NR1H4
2transportGO:0068109.2ABCC2, ABCB11, ABCB4
3transmembrane transportGO:0550859.2ABCC2, ABCB11, ABCB4
4intracellular receptor signaling pathwayGO:0305229.0NR1H4, NR1I3

Molecular functions related to Intrahepatic Cholestasis of Pregnancy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityGO:0048799.1NR1H4, NR1I3
2ATPase activity, coupled to transmembrane movement of substancesGO:0426269.1ABCC2, ABCB11, ABCB4
3thyroid hormone receptor activityGO:0048878.8NR1H4, NR1I3

Products for genes affiliated with Intrahepatic Cholestasis of Pregnancy

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Sources for Intrahepatic Cholestasis of Pregnancy

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet