ICP
MCID: INT099
MIFTS: 41

Intrahepatic Cholestasis of Pregnancy (ICP) malady

Reproductive diseases, Genetic diseases categories

Summaries for Intrahepatic Cholestasis of Pregnancy

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21Genetics Home Reference, 63Wikipedia, 32MalaCards
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Genetics Home Reference:21 Intrahepatic cholestasis of pregnancy is a liver disorder that occurs in pregnant women. Cholestasis is a condition that impairs the release of a digestive fluid called bile from liver cells. As a result, bile builds up in the liver, impairing liver function. Because the problems with bile release occur within the liver (intrahepatic), the condition is described as intrahepatic cholestasis. Intrahepatic cholestasis of pregnancy usually becomes apparent in the third trimester of pregnancy. Bile flow returns to normal after delivery of the baby, and the signs and symptoms of the condition disappear. However, they can return during later pregnancies.

MalaCards: Intrahepatic Cholestasis of Pregnancy, also known as familial intrahepatic cholestasis of pregnancy, is related to intrahepatic cholestasis and cholestasis. An important gene associated with Intrahepatic Cholestasis of Pregnancy is ABCB4 (ATP-binding cassette, sub-family B (MDR/TAP), member 4), and among its related pathways are Pravastatin Pathway, Pharmacokinetics and Endosomal/Vacuolar pathway. The compounds wort and bromosulfophthalein have been mentioned in the context of this disorder. Affiliated tissues include liver, and related mouse phenotypes are liver/biliary system and immune system.

Wikipedia:63 Intrahepatic cholestasis of pregnancy (ICP), also known as obstetric cholestasis, cholestasis of... more...

Aliases & Classifications for Intrahepatic Cholestasis of Pregnancy

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42NIH Rare Diseases, 20GeneTests, 21Genetics Home Reference, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases
Anatomical: Reproductive diseases


Aliases & Descriptions:

intrahepatic cholestasis of pregnancy 42 21
familial intrahepatic cholestasis of pregnancy 42 20
familial recurrent intrahepatic cholestasis of pregnancy 42
recurrent intrahepatic cholestasis of pregnancy 21
cholestasis, intrahepatic of pregnancy 42
progressive intrahepatic cholestasis 60
pregnancy related cholestasis 42
pregnancy-related cholestasis 21
cholestasis of pregnancy 60
obstetric cholestasis 21
icp 42


Related Diseases for Intrahepatic Cholestasis of Pregnancy

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17GeneCards, 18GeneDecks
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Diseases in the Cholestasis, Intrahepatic, of Pregnancy, 1 family:

intrahepatic cholestasis of pregnancy Cholestasis, Intrahepatic, of Pregnancy, 3

Diseases related to Intrahepatic Cholestasis of Pregnancy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 94)
idRelated DiseaseScoreTop Affiliating Genes
1intrahepatic cholestasis32.1ABCC2, ABCB11, ABCB4, GGT1, NR1I2, ATP8B1
2cholestasis32.1ATP8B1, ABCB7, NR1I2, NR1H4, LAP3, GGT1
3hepatitis30.8ABCC2, ABCB7, GGT1, AHSG, GPT
4viral hepatitis30.5GGT1, ABCB7, GPT
5choledocholithiasis30.3GPT, GGT1
6diabetes mellitus30.3ESR2, NR1H4, GPT, AHSG, GGT1
7breast cancer30.3ABCC2, NR1H4, NR1I2, HLA-G, CYP1B1, ABCB11
8low gamma-gt familial intrahepatic cholestasis30.2ATP8B1, ABCB11
9benign recurrent intrahepatic cholestasis30.2ABCB11, ATP8B1
10cholestasis, progressive familial intrahepatic 330.2ATP8B1, ABCB11, ABCB4
11cholestasis, progressive familial intrahepatic 130.2GGT1, ATP8B1, ABCB11, ABCB4, NR1H4
12fatty liver disease30.1GGT1
13cholelithiasis30.1GPT, ABCB11, ABCB4, GGT1
14hypertension29.9GGT1
15cholestasis, intrahepatic, of pregnancy, 110.5
16eclampsia10.4
17liver disease10.4
18pre-eclampsia10.4
19hydrocephalus10.3
20cerebritis10.3
21intracranial hypertension10.3
22impetigo herpetiformis10.2
23steatorrhea10.2
24gestational diabetes10.2
25drug-induced hepatitis10.2
26hepatitis a10.2
27impetigo10.2
28cholestasis, intrahepatic, of pregnancy, 310.2
29pregnancy loss, recurrent 110.2
30intracranial aneurysm10.2
31normal pressure hydrocephalus10.1
32brain compression10.1
33intracranial embolism10.1
34communicating hydrocephalus10.1
35gallbladder disease10.1
36primary biliary cirrhosis10.0SLC4A2
37arthritis10.0ESR2
38myocardial infarction10.0ABCB7
39severe pre-eclampsia10.0HLA-G
40pancreatitis10.0ABCB4, GGT1
41colon cancer10.0ESR2
42cholestasis, progressive familial intrahepatic 210.0ABCB4, ABCB11, ATP8B1
43acute pancreatitis10.0GPT, ABCB7
44alagille syndrome10.0ATP8B1, ABCB4
45celiac disease10.0HLA-DPA1, HLA-G
46malaria10.0IL12B
47leukopenia10.0ABCB7, GPT, HLA-G
48myeloma10.0HLA-G, HLA-E
49infertility10.0HLA-G, ESR2, AHSG
50substance abuse10.0GGT1

Graphical network of the top 20 diseases related to Intrahepatic Cholestasis of Pregnancy:



Diseases related to intrahepatic cholestasis of pregnancy

Clinical Features for Intrahepatic Cholestasis of Pregnancy

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Drugs & Therapeutics for Intrahepatic Cholestasis of Pregnancy

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Intrahepatic Cholestasis of Pregnancy

Drug clinical trials:

Search ClinicalTrials for Intrahepatic Cholestasis of Pregnancy

Search NIH Clinical Center for Intrahepatic Cholestasis of Pregnancy

Search CenterWatch for Intrahepatic Cholestasis of Pregnancy

Genetic Tests for Intrahepatic Cholestasis of Pregnancy

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20GeneTests
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Genetic tests related to Intrahepatic Cholestasis of Pregnancy:

id Genetic test Affiliating Genes
1 Cholestasis, Familial Intrahepatic, of Pregnancy20 ABCB4

Anatomical Context for Intrahepatic Cholestasis of Pregnancy

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32MalaCards
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MalaCards organs/tissues related to Intrahepatic Cholestasis of Pregnancy:

32
Liver

Animal Models for Intrahepatic Cholestasis of Pregnancy or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Intrahepatic Cholestasis of Pregnancy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053709.4ATP8B1, NR1I2, NR1H4, ABCC2, ABCB11, ABCB7
2MP:00053879.3HLA-G, NR1H4, IL12B, ABCB4, SLC4A2, SLCO1A2
3MP:00053768.7ESR2, HLA-E, HLA-G, ATP8B1, NR1I2, NR1H4

Publications for Intrahepatic Cholestasis of Pregnancy

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Genetic Variations for Intrahepatic Cholestasis of Pregnancy

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Expression for genes affiliated with Intrahepatic Cholestasis of Pregnancy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Intrahepatic Cholestasis of Pregnancy

Search GEO for disease gene expression data for Intrahepatic Cholestasis of Pregnancy.

Pathways for genes affiliated with Intrahepatic Cholestasis of Pregnancy

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Sources:
49PharmGKB, 53Reactome, 37NCBI BioSystems Database, 12EMD Millipore, 51QIAGEN, 29KEGG
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Pathways related to Intrahepatic Cholestasis of Pregnancy according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3ABCB11, ABCC2
210.3HLA-E, HLA-G
3
Hide members
10.2NR1H4, ESR2, NR1I2
410.2SLC4A2, NR1I2, NR1H4
510.1ABCB4, ABCC2, ABCB11, SLCO1A2
610.1ABCC2, NR1I2, NR1H4, ABCB11
7
Hide members
10.1ABCC2, ABCB11, ABCB7, ABCB4
8
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10.0CES1, ABCC2, CYP1B1, NR1I2
910.0NR1I2, NR1H4, ABCC2, ABCB4, ABCB11
10
Hide members
10.0HLA-DPA1, HLA-E, HLA-G, IL12B
11
Hide members
10.0HLA-DPA1, IL12B, HLA-G, HLA-E
12
Hide members
9.9ATP8B1, ABCC2, ABCB7, SLC4A2, SLCO1A2
139.9SLC4A2, SLCO1A2, ABCB4, ABCB11, ABCC2, NR1H4
14
Hide members
9.6SLCO1A2, GPT, GGT1, LAP3, CES1, ABCB11

Compounds for genes affiliated with Intrahepatic Cholestasis of Pregnancy

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44Novoseek, 28IUPHAR, 24HMDB, 59Tocris Bioscience, 49PharmGKB, 11DrugBank, 2BitterDB
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Compounds related to Intrahepatic Cholestasis of Pregnancy according to GeneCards/GeneDecks:

(show top 50)    (show all 135)
idCompoundScoreTop Affiliating Genes
1wort4410.5NR1I2, ABCB11, ABCC2
2bromosulfophthalein4410.5GPT, ABCC2, SLCO1A2
3lithocholic acid44 28 2412.5NR1I2, ABCB11, SLCO1A2, NR1H4
4glycocholate4410.5ABCB4, ABCB11, ABCC2, GPT
5gw 406444 5911.5NR1I2, ABCC2, NR1H4
6ethinyl estradiol49 1111.5ABCC2, ABCB11, NR1I2
7rifampin49 1111.5ABCC2, ABCB11, SLCO1A2, NR1I2
8paclitaxel44 49 1112.5ABCC2, IL12B, CYP1B1
9estrogen4410.4CES1, ABCB4, ABCC2, AHSG
10digoxin44 49 59 11 2414.4NR1I2, ABCC2, ABCB11, SLCO1A2
11rosuvastatin44 49 28 1113.4ABCC2, ABCB11, SLCO1A2, GPT
12flavonoid4410.4CES1, ABCC2, LAP3, CYP1B1
13ketoconazole44 28 11 2413.4SLCO1A2, ABCC2, CYP1B1, NR1I2, ABCB11
14taurocholate4410.4ABCB11, ATP8B1, NR1H4, ABCB4, SLCO1A2, ABCC2
15ritonavir44 49 1112.4SLCO1A2, ABCB11, ABCC2, NR1I2
16cholic acid44 28 11 2413.3ABCC2, NR1H4, SLCO1A2, CES1, NR1I2, ABCB11
17glucose4410.3NR1I2, LAP3, NR1H4, ABCB11, AHSG
18pravastatin44 49 28 11 2414.3CES1, SLCO1A2, ABCB11, ABCC2, GPT, ABCB7
19phenytoin44 49 28 1113.3ABCC2, ABCB11, NR1I2, GGT1
20mycophenolate mofetil44 49 1112.3CES1, GGT1, ABCC2, GPT
21phosphorus4410.3LAP3, GPT, GGT1, ABCB7
22vitamin-e4410.3GPT, ABCB7, NR1I2, CES1, GGT1
23rifampicin44 28 5912.3SLCO1A2, ABCC2, NR1I2, ABCB11, GGT1, GPT
24daunorubicin44 49 1112.3ABCC2, CYP1B1, ABCB4, ABCB11
25dexamethasone44 49 28 1113.2NR1I2, GGT1, ABCC2, ABCB4, SLCO1A2, CYP1B1
26verapamil44 49 28 11 2414.2ABCB11, GGT1, GPT, ABCC2, SLCO1A2, ABCB4
27chenodeoxycholic acid44 28 11 2413.2GPT, NR1I2, ABCC2, NR1H4, SLCO1A2, ABCB4
28tacrolimus44 49 1112.2GPT, GGT1, ABCB4, ABCB11, ABCC2, NR1I2
29phenobarbital44 28 1112.2NR1I2, ABCB11, CYP1B1, GGT1, GPT, ABCC2
30lovastatin44 49 59 28 1114.2ABCC2, GPT, NR1I2, GGT1, CES1, SLCO1A2
31urea44 11 2412.2HLA-G, GPT, ABCC2, CES1, ABCB7, GGT1
32cyclosporine49 1111.2ABCB11, ABCC2, SLCO1A2
33methotrexate44 49 1112.2HLA-G, GPT, ABCC2, ABCB4, SLCO1A2, GGT1
34vitamin d4410.1NR1H4, NR1I2, ESR2, GPT, IL12B, AHSG
35quercetin44 59 11 2413.1ABCC2, GGT1, ESR2, NR1I2, CYP1B1
36acetaminophen44 2 49 11 2414.1GGT1, NR1I2, GPT, ABCC2
37rhodamine 12344 4911.1ABCC2, ABCB11, ABCB4
38tamoxifen44 49 28 1113.1CYP1B1, CES1, ESR2, GGT1, ABCB11, NR1I2
39doxorubicin44 49 1112.1ABCC2, NR1I2, ABCB11, CYP1B1, ABCB4, ESR2
40chloride4410.1ABCB11, SLC4A2, ABCB7, GPT, ABCC2
41arsenite44 2411.1SLC4A2, NR1I2, CYP1B1, ABCC2, GGT1
42ethanol44 49 11 2413.0CES1, LAP3, GGT1, ABCB7, GPT, AHSG
43ursodeoxycholic acid44 11 2412.0ABCB4, SLCO1A2, GGT1, NR1H4, NR1I2, GPT
44progesterone44 59 28 11 2414.0HLA-G, ABCC2, CES1, ESR2, ABCB7, ABCB11
45testosterone44 59 11 2413.0NR1H4, CYP1B1, ABCB7, NR1I2, SLCO1A2, CES1
46sodium44 2410.9NR1H4, ABCB7, HLA-G, ABCC2, GPT, SLC4A2
47cholesterol44 28 11 2412.8ATP8B1, ABCB4, GPT, NR1I2, ABCB7, SLCO1A2
48nevirapine44 49 1111.8GPT, ABCB7, GGT1
49creatinine449.8GGT1, LAP3, ABCC2, GPT, HLA-G, ABCB7
50lipid449.4ABCB4, CYP1B1, HLA-G, ABCB11, GGT1, NR1H4

GO Terms for genes affiliated with Intrahepatic Cholestasis of Pregnancy

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16Gene Ontology
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Cellular components related to Intrahepatic Cholestasis of Pregnancy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intercellular canaliculusGO:04658110.4ABCC2, ABCB11, ABCB4
2integral to lumenal side of endoplasmic reticulum membraneGO:07155610.2HLA-DPA1, HLA-E, HLA-G
3ER to Golgi transport vesicle membraneGO:01250710.2HLA-DPA1, HLA-E, HLA-G
4apical plasma membraneGO:01632410.0ATP8B1, ABCC2, ABCB11, ABCB4
5MHC class I protein complexGO:04261210.0HLA-G, HLA-E
6Golgi membraneGO:00013910.0ABCB4, ABCB11, HLA-G, HLA-E, HLA-DPA1
7plasma membraneGO:0058869.4SLCO1A2, ABCC2, ATP8B1, HLA-G, HLA-E, GGT1

Biological processes related to Intrahepatic Cholestasis of Pregnancy according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1bile acid and bile salt transportGO:01572110.3SLCO1A2, ABCB11, ATP8B1
2bile acid metabolic processGO:00820610.3SLCO1A2, ABCB11, NR1H4, ATP8B1
3positive regulation of T cell mediated cytotoxicityGO:00191610.2HLA-E, HLA-G, IL12B
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independentGO:00248010.2HLA-G, HLA-E
5interferon-gamma-mediated signaling pathwayGO:06033310.1HLA-G, HLA-E, HLA-DPA1
6transportGO:00681010.1ABCB4, ABCB7, ABCB11, ABCC2
7transmembrane transportGO:0550859.9ATP8B1, ABCC2, ABCB11, ABCB7, ABCB4, SLC4A2
8small molecule metabolic processGO:0442819.4CYP1B1, GPT, ABCB11, ABCB7, ABCB4, SLCO1A2

Molecular functions related to Intrahepatic Cholestasis of Pregnancy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1organic anion transmembrane transporter activityGO:00851410.3SLCO1A2, ABCC2
2ATPase activity, coupled to transmembrane movement of substancesGO:04262610.1ABCB4, ABCB7, ABCB11, ABCC2
3ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityGO:00487910.1NR1I2, NR1H4, ESR2
4steroid hormone receptor activityGO:0037079.9ESR2, NR1H4, NR1I2

Products for genes affiliated with Intrahepatic Cholestasis of Pregnancy

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Sources for Intrahepatic Cholestasis of Pregnancy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet