ICP
MCID: INT099
MIFTS: 53

Intrahepatic Cholestasis of Pregnancy (ICP) malady

Genetic diseases, Rare diseases, Reproductive diseases, Liver diseases categories
Download this MalaCard

Summaries for Intrahepatic Cholestasis of Pregnancy

About this section


Fully expand this MalaCard
Genetics Home Reference:21 Intrahepatic cholestasis of pregnancy is a liver disorder that occurs in pregnant women. Cholestasis is a condition that impairs the release of a digestive fluid called bile from liver cells. As a result, bile builds up in the liver, impairing liver function. Because the problems with bile release occur within the liver (intrahepatic), the condition is described as intrahepatic cholestasis. Intrahepatic cholestasis of pregnancy usually becomes apparent in the third trimester of pregnancy. Bile flow returns to normal after delivery of the baby, and the signs and symptoms of the condition disappear. However, they can return during later pregnancies.

MalaCards based summary: Intrahepatic Cholestasis of Pregnancy, also known as recurrent intrahepatic cholestasis of pregnancy, is related to cholestasis and benign recurrent intrahepatic cholestasis. An important gene associated with Intrahepatic Cholestasis of Pregnancy is ATP8B1 (ATPase, aminophospholipid transporter, class I, type 8B, member 1), and among its related pathways are Synthesis of bile acids and bile salts and Methotrexate Pathway, Pharmacokinetics. The compounds fusidic acid and glycochenodeoxycholic acid have been mentioned in the context of this disorder. Affiliated tissues include liver, placenta and testes, and related mouse phenotypes are liver/biliary system and homeostasis/metabolism.

Wikipedia:65 Intrahepatic cholestasis of pregnancy (ICP), also known as obstetric cholestasis, cholestasis of... more...

Aliases & Classifications for Intrahepatic Cholestasis of Pregnancy

About this section

Intrahepatic Cholestasis of Pregnancy, Aliases & Descriptions:

Name: Intrahepatic Cholestasis of Pregnancy 42 21 62
Recurrent Intrahepatic Cholestasis of Pregnancy 42 21 62
Familial Recurrent Intrahepatic Cholestasis of Pregnancy 42 62
Familial Intrahepatic Cholestasis of Pregnancy 42 20
Pregnancy-Related Cholestasis 21 62
Obstetric Cholestasis 21 62
 
Ricp 42 62
Cholestasis, Intrahepatic of Pregnancy 42
Progressive Intrahepatic Cholestasis 62
Pregnancy Related Cholestasis 42
Cholestasis of Pregnancy 62
Icp 42


Classifications:



Related Diseases for Intrahepatic Cholestasis of Pregnancy

About this section

Diseases in the Cholestasis, Intrahepatic, of Pregnancy, 1 family:

intrahepatic cholestasis of pregnancy Cholestasis, Intrahepatic, of Pregnancy, 3

Diseases related to Intrahepatic Cholestasis of Pregnancy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 60)
idRelated DiseaseScoreTop Affiliating Genes
1cholestasis31.2NR1I3, ABCB4, ATP8B1, ABCB11, ABCC2, NR1H4
2benign recurrent intrahepatic cholestasis31.0ABCB11, ATP8B1
3intrahepatic cholestasis30.9ATP8B1, NR1H4, NR1I3, NR1I2, ABCB4, ABCB11
4breast cancer29.4ABCC2, ABCB11, ABCB4, NR1I2, NR1I3, NR1H4
5hepatitis10.7
6cholestasis, intrahepatic, of pregnancy, 110.7
7cholangitis10.5ABCB4
8eclampsia10.4
9pre-eclampsia10.4
10viral hepatitis10.4
11hypoxia10.4
12hydrocephalus10.4
13cerebritis10.3
14intracranial hypertension10.3
15diabetes mellitus10.3
16hepatitis b10.3
17liver disease10.3
18hellp syndrome10.3
19choledocholithiasis10.3
20gestational diabetes10.3
21steatorrhea10.3
22impetigo herpetiformis10.3
23impetigo10.3
24acute fatty liver of pregnancy10.3
25hepatitis b virus infection10.3
26cholestasis, intrahepatic, of pregnancy, 310.3
27blindness10.3
28aneurysm10.3
29cholelithiasis10.2ABCB4, ABCB11
30head injury10.2
31low gamma-gt familial intrahepatic cholestasis10.2ABCB11, ATP8B1
32alagille syndrome10.2ABCB4, ATP8B1
33brain injury10.1
34normal pressure hydrocephalus10.1
35brain compression10.1
36communicating hydrocephalus10.1
37cerebral aneurysms10.1
38cerebrotendinous xanthomatosis10.1NR1I2, NR1H4
39cholestasis, progressive familial intrahepatic 210.1ABCB4, ABCB11, ATP8B1
40cholestasis, progressive familial intrahepatic 310.1ABCB4, ABCB11, ATP8B1
41biliary atresia10.1ATP8B1, NR1H4
42bilirubin metabolic disorder10.0NR1I3, ABCC2
43craniosynostosis10.0
44hypertension10.0
45traumatic brain injury10.0
46arachnoiditis10.0
47intracranial hypotension10.0
48brain edema10.0
49intracranial aneurysm10.0
50arachnoid cysts10.0

Graphical network of the top 20 diseases related to Intrahepatic Cholestasis of Pregnancy:



Diseases related to intrahepatic cholestasis of pregnancy

Symptoms for Intrahepatic Cholestasis of Pregnancy

About this section

Drugs & Therapeutics for Intrahepatic Cholestasis of Pregnancy

About this section

Drug clinical trials:

Search ClinicalTrials for Intrahepatic Cholestasis of Pregnancy

Search NIH Clinical Center for Intrahepatic Cholestasis of Pregnancy

Genetic Tests for Intrahepatic Cholestasis of Pregnancy

About this section

Genetic tests related to Intrahepatic Cholestasis of Pregnancy:

id Genetic test Affiliating Genes
1 Cholestasis, Familial Intrahepatic, of Pregnancy20 ABCB4

Anatomical Context for Intrahepatic Cholestasis of Pregnancy

About this section

MalaCards organs/tissues related to Intrahepatic Cholestasis of Pregnancy:

32
Liver, Placenta, Testes, Smooth muscle, Breast, Neutrophil

Animal Models for Intrahepatic Cholestasis of Pregnancy or affiliated genes

About this section

MGI Mouse Phenotypes related to Intrahepatic Cholestasis of Pregnancy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053706.8NR1H4, ABCB4, ABCB11, ABCC2, ATP8B1, NR1I2
2MP:00053766.3ABCB11, ABCC2, ATP8B1, HLA-G, AHSG, NR1I2

Publications for Intrahepatic Cholestasis of Pregnancy

About this section

Articles related to Intrahepatic Cholestasis of Pregnancy:

(show top 50)    (show all 279)
idTitleAuthorsYear
1
Placental gene-expression profiles of intrahepatic cholestasis of pregnancy reveal involvement of multiple molecular pathways in blood vessel formation and inflammation. (25001852)
2014
2
Effect of taurocholic acid on fetoplacental arterial pressures in a dual perfusion placental cotyledon model: a novel approach to intrahepatic cholestasis of pregnancy. (25098026)
2014
3
Intrahepatic Cholestasis of Pregnancy: mRNAs for LIPF and ELOVL4 Genes Are Not Detectable in Circulating Maternal Plasma. (25059952)
2014
4
Fetal complications due to intrahepatic cholestasis of pregnancy. (25153210)
2014
5
Impaired fetal myocardial deformation in intrahepatic cholestasis of pregnancy. (24958403)
2014
6
Intrahepatic cholestasis of pregnancy: maternal and fetal outcomes associated with elevated bile acid levels. (25046809)
2014
7
Reduced Plasma Corticotropin-Releasing Hormone Levels during Late Gestation in Patients with Intrahepatic Cholestasis of Pregnancy. (25059485)
2014
8
Ursodeoxycholic acid in the treatment of intrahepatic cholestasis of pregnancy: a randomized controlled trial. (23978872)
2013
9
Primary bile acids as potential biomarkers for the clinical grading of intrahepatic cholestasis of pregnancy. (23562588)
2013
10
Study on the regulation of cell adhesion molecule expression and function in placenta from women with intrahepatic cholestasis of pregnancy. (23810461)
2013
11
Menopause after a history of intrahepatic cholestasis of pregnancy. (24149924)
2013
12
Intrahepatic cholestasis of pregnancy: correlation of preterm delivery with bile acids. (22287405)
2011
13
Pregnancy outcome in cases of intrahepatic cholestasis of pregnancy. (21247575)
2011
14
Relationship between umbilical artery Doppler waveform analysis and perinatal prognosis in women with intrahepatic cholestasis of pregnancy. (20705289)
2010
15
High mean platelet volume, low-grade systemic coagulation, and fibrinolytic activation are associated with pre-term delivery and low APGAR score in intrahepatic cholestasis of pregnancy. (20670095)
2010
16
Expression of HLA-G protein in placental tissues and its influence on Th1/Th2 cytokines in peripheral blood in patients with intrahepatic cholestasis of pregnancy]. (20360645)
2010
17
The influence of common gene variants of the xenobiotic receptor (PXR) in genetic susceptibility to intrahepatic cholestasis of pregnancy. (19958310)
2010
18
Combined functional variants of hepatobiliary transporters and FXR aggravate intrahepatic cholestasis of pregnancy. (19490418)
2009
19
Contribution of variant alleles of ABCB11 to susceptibility to intrahepatic cholestasis of pregnancy. (18987030)
2009
20
Hepatobiliary phospholipid transporter ABCB4, MDR3 gene variants in a large cohort of Italian women with intrahepatic cholestasis of pregnancy. (18083082)
2008
21
Association of gene polymorphisms of CYP1B1 with intrahepatic cholestasis of pregnancy]. (18575334)
2008
22
Intrahepatic cholestasis of pregnancy in women with a multiple pregnancy: an analysis of risks and pregnancy outcomes. (19126282)
2008
23
Linkage between a new splicing site mutation in the MDR3 alias ABCB4 gene and intrahepatic cholestasis of pregnancy. (17187437)
2007
24
The importance of serum bile acid level analysis and treatment with ursodeoxycholic acid in intrahepatic cholestasis of pregnancy: a case series from central Europe. (17576942)
2007
25
Association between polymorphisms of CYP17 and CYP3A4 genes and intrahepatic cholestasis of pregnancy in Chengdu]. (16909599)
2006
26
Potential role of trans-inhibition of the bile salt export pump by progesterone metabolites in the etiopathogenesis of intrahepatic cholestasis of pregnancy. (16458994)
2006
27
Plasma lipid profiles of women with intrahepatic cholestasis of pregnancy. (16394047)
2006
28
Intrahepatic cholestasis of pregnancy: Relationships between bile acid levels and fetal complication rates. (15368452)
2004
29
Diagnosis and therapy of intrahepatic cholestasis of pregnancy. (15248112)
2004
30
A second heterozygous MDR3 nonsense mutation associated with intrahepatic cholestasis of pregnancy. (12624161)
2003
31
Intrahepatic cholestasis of pregnancy: review of the literature. (11773831)
2002
32
Intrahepatic cholestasis of pregnancy: what's new. (12224684)
2002
33
Ursodeoxycholic acid for the treatment of intrahepatic cholestasis of pregnancy. (11392594)
2001
34
Oral guar gum, a gel-forming dietary fiber relieves pruritus in intrahepatic cholestasis of pregnancy. (10746839)
2000
35
Intrahepatic cholestasis of pregnancy has no effect on maternal serum second trimester alpha-fetoprotein and hCG. (10929953)
2000
36
Apolipoprotein E alleles in women with intrahepatic cholestasis of pregnancy. (11063158)
2000
37
Bile acids and progesterone metabolites in intrahepatic cholestasis of pregnancy. (10766400)
2000
38
Hepatitis G virus infection detected in a woman with intrahepatic cholestasis of pregnancy. (9890225)
1998
39
A randomised placebo-controlled trial of ursodeoxycholic acid and S-adenosylmethionine in the treatment of intrahepatic cholestasis of pregnancy. (9853771)
1998
40
Intrahepatic cholestasis of pregnancy. (9638904)
1998
41
Severe fetal intracranial haemorrhage during treatment with cholestyramine for intrahepatic cholestasis of pregnancy. (7756215)
1995
42
Serum conjugated bile acid profile during intrahepatic cholestasis of pregnancy. (7751589)
1995
43
Intrahepatic cholestasis of pregnancy. (7888831)
1994
44
Intrahepatic cholestasis of pregnancy: a retrospective case-control study of perinatal outcome. (8141222)
1994
45
Ursodeoxycholic acid treatment of intrahepatic cholestasis of pregnancy: observations on efficacy and safety. (8425713)
1993
46
Epomediol ameliorates pruritus in patients with intrahepatic cholestasis of pregnancy. (1484159)
1992
47
Intrahepatic cholestasis of pregnancy and acute fatty liver of pregnancy. An unusual but favorable association? (2001812)
1991
48
Serum copper in intrahepatic cholestasis of pregnancy. (1820694)
1991
49
S-adenosylmethionine for the treatment of intrahepatic cholestasis of pregnancy. Results of a controlled clinical trial. (2083923)
1990
50
Familial recurrent intrahepatic cholestasis of pregnancy: a genetic study providing evidence for transmission of a sex-limited, dominant trait. (6852450)
1983

Variations for Intrahepatic Cholestasis of Pregnancy

About this section

Clinvar genetic disease variations for Intrahepatic Cholestasis of Pregnancy:

6
id Gene Name Type Significance SNP ID Assembly Location
1ATP8B1NM_005603.4(ATP8B1): c.1993G> T (p.Glu665Ter)single nucleotide variantPathogenicrs515726137GRCh37Chr 18, 55336654: 55336654
2ATP8B1NM_005603.4(ATP8B1): c.625C> A (p.Pro209Thr)single nucleotide variantPathogenicrs515726138GRCh38Chr 18, 57697797: 57697797
3ATP8B1NM_005603.4(ATP8B1): c.923G> T (p.Gly308Val)single nucleotide variantPathogenicrs111033609GRCh37Chr 18, 55362420: 55362420
4NM_005603.4(ATP8B1): c.2674G> A (p.Gly892Arg)single nucleotide variantPathogenicrs121909098GRCh37Chr 18, 55328439: 55328439
5ATP8B1NM_005603.4(ATP8B1): c.863T> C (p.Leu288Ser)single nucleotide variantPathogenicrs121909099GRCh37Chr 18, 55362480: 55362480
6ATP8B1NM_005603.4(ATP8B1): c.2097+2T> Csingle nucleotide variantPathogenicrs387906381GRCh37Chr 18, 55336548: 55336548
7ATP8B1NM_005603.4(ATP8B1): c.1982T> C (p.Ile661Thr)single nucleotide variantPathogenicrs121909100GRCh37Chr 18, 55336665: 55336665
8ATP8B1NM_005603.4(ATP8B1): c.1660G> A (p.Asp554Asn)single nucleotide variantPathogenicrs121909101GRCh37Chr 18, 55342225: 55342225
9ATP8B1NM_005603.4(ATP8B1): c.1367C> T (p.Thr456Met)single nucleotide variantPathogenicrs121909104GRCh37Chr 18, 55355593: 55355593
10ATP8B1NM_005603.4(ATP8B1): c.1804C> T (p.Arg602Ter)single nucleotide variantPathogenicrs121909105GRCh37Chr 18, 55342081: 55342081

Expression for genes affiliated with Intrahepatic Cholestasis of Pregnancy

About this section
Expression patterns in normal tissues for genes affiliated with Intrahepatic Cholestasis of Pregnancy

Search GEO for disease gene expression data for Intrahepatic Cholestasis of Pregnancy.

Pathways for genes affiliated with Intrahepatic Cholestasis of Pregnancy

About this section

Pathways related to Intrahepatic Cholestasis of Pregnancy according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6SLCO1A2, ABCB11
2
Show member pathways
9.3ABCC2, SLCO1A2
3
Show member pathways
9.2ABCB4, ABCB11, ABCC2
4
Show member pathways
9.0NR1I2, ABCC2
5
Show member pathways
9.0SLCO1A2, ABCC2, ABCB11
6
Show member pathways
Nuclear Receptors37
8.7NR1H4, NR1I3, NR1I2
7
Show member pathways
8.7ABCB4, ABCB11, ABCC2, SLCO1A2
88.5NR1I3, NR1I2, ABCC2
98.3SLCO1A2, NR1H4, ABCC2, ABCB11, ABCB4
107.8ABCB11, ABCC2, NR1I2, NR1I3, NR1H4
117.4NR1H4, NR1I3, NR1I2, ABCC2, ABCB11, ABCB4

Compounds for genes affiliated with Intrahepatic Cholestasis of Pregnancy

About this section

Compounds related to Intrahepatic Cholestasis of Pregnancy according to GeneCards/GeneDecks:

(show top 50)    (show all 171)
idCompoundScoreTop Affiliating Genes
1fusidic acid44 1110.7ABCB11, ABCC2
2glycochenodeoxycholic acid44 1110.6ABCB11, SLCO1A2
3glycocholate449.6ABCB4, ABCC2, ABCB11
4rhodamine 12344 5010.5ABCB4, ABCC2, ABCB11
5deoxycholic acid44 28 24 1112.5SLCO1A2, NR1H4, ABCB11
6androstanol449.4NR1I2, NR1I3
7pregnanedione289.4NR1I2, NR1I3
8Taurocholic acid24 1110.3SLCO1A2, ABCC2, ABCB11
9cyclosporine50 1110.3SLCO1A2, ABCB11, ABCC2
10saquinavir44 1110.3SLCO1A2, ABCC2, ABCB11
11rosuvastatin44 50 28 1112.3ABCB11, SLCO1A2, ABCC2
12gf 120918449.2ABCB11, ABCC2
13quinidine44 28 50 1112.2SLCO1A2, ABCC2, ABCB11
14erythromycin44 2 50 1112.1ABCC2, SLCO1A2, ABCB11
15quinine44 28 2 50 1113.1ABCC2, ABCB11, SLCO1A2
16wort449.1NR1I2, ABCC2, ABCB11
17ethinyl estradiol50 1110.1ABCB11, ABCC2, NR1I2
18androstenol449.0NR1I2, NR1I3
19verapamil44 28 50 24 1113.0ABCB4, SLCO1A2, ABCC2, ABCB11
20gw 406461 4410.0NR1I2, ABCC2, NR1H4
21hyperforin28 44 1110.9ABCC2, NR1I2, NR1I3
22colchicine44 61 2 28 1112.8ABCB4, ABCB11, NR1I2, NR1I3
23indinavir44 50 1110.8SLCO1A2, NR1I2, ABCC2
24omeprazole44 50 28 24 1112.8NR1I3, ABCC2, NR1I2
25clotrimazole28 44 24 1111.8NR1I3, NR1I2, ABCC2
26dhea448.7NR1I2, NR1H4, NR1I3
27tacrolimus44 50 1110.7ABCB4, NR1I2, ABCC2, ABCB11
28rifampin50 119.6NR1I2, ABCC2, ABCB11, SLCO1A2
29digoxin44 61 50 24 1112.6SLCO1A2, ABCC2, ABCB11, NR1I2
30ritonavir44 50 1110.6ABCC2, ABCB11, SLCO1A2, NR1I2
31ketoconazole44 28 24 1111.6ABCB11, ABCC2, SLCO1A2, NR1I2
32phenytoin44 50 28 1111.6NR1I2, ABCB11, ABCC2, NR1I3
33phenobarbital44 28 50 1111.5NR1I2, NR1I3, ABCC2, ABCB11
34androstane448.5NR1H4, NR1I3, NR1I2, ABCC2
35taurocholate448.4ABCB4, ABCB11, ABCC2, ATP8B1, NR1H4, SLCO1A2
36vitamin d448.3NR1I3, NR1H4, AHSG, NR1I2
37lithocholic acid44 28 2410.3SLCO1A2, NR1H4, NR1I3, NR1I2, ABCB11
38oligonucleotide448.3NR1I2, NR1I3, ABCB4, HLA-G, ABCB11
39paclitaxel44 50 1110.2ABCB4, ABCB11, ABCC2, NR1I2, NR1I3
40methotrexate50 44 1110.2HLA-G, SLCO1A2, NR1I2, ABCB4, ABCC2
41cyclosporin a44 28 6110.2ABCB4, ABCB11, ABCC2, NR1I2, NR1I3
42cholic acid44 28 24 1111.2NR1I2, NR1H4, ABCC2, SLCO1A2, ABCB11
43rifampicin44 28 6110.1NR1I2, ABCC2, ABCB11, SLCO1A2, NR1I3
44ursodeoxycholic acid44 24 119.9ABCB11, ABCC2, NR1I2, SLCO1A2, NR1H4, ABCB4
45progesterone44 28 61 24 1111.8ABCC2, ABCB11, HLA-G, NR1I2, NR1I3, NR1H4
46estrogen447.4AHSG, NR1I2, ABCB11, ABCB4, NR1I3, NR1H4
47chenodeoxycholic acid44 28 24 1110.4ABCB4, SLCO1A2, NR1H4, NR1I3, NR1I2, ABCC2
48cholesterol44 28 24 1110.3SLCO1A2, NR1H4, NR1I2, HLA-G, ATP8B1, ABCB11
49lipid447.2ATP8B1, HLA-G, NR1I2, NR1I3, NR1H4, ABCB11
50dexamethasone44 50 28 1110.0HLA-G, SLCO1A2, NR1I3, NR1I2, ABCC2, ABCB11

GO Terms for genes affiliated with Intrahepatic Cholestasis of Pregnancy

About this section

Cellular components related to Intrahepatic Cholestasis of Pregnancy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intercellular canaliculusGO:0465818.9ABCC2, ABCB11, ABCB4
2apical plasma membraneGO:0163248.9ATP8B1, ABCC2, ABCB11, ABCB4

Biological processes related to Intrahepatic Cholestasis of Pregnancy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1bile acid and bile salt transportGO:0157219.3SLCO1A2, ATP8B1, ABCB11
2bile acid metabolic processGO:0082069.0SLCO1A2, NR1H4, ATP8B1, ABCB11
3transcription initiation from RNA polymerase II promoterGO:0063678.7NR1H4, NR1I3, NR1I2
4intracellular receptor signaling pathwayGO:0305228.6NR1I2, NR1I3, NR1H4
5transmembrane transportGO:0550858.1SLCO1A2, ATP8B1, ABCC2, ABCB11, ABCB4

Molecular functions related to Intrahepatic Cholestasis of Pregnancy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1thyroid hormone receptor activityGO:0048879.4NR1I3, NR1H4
2ATPase activity, coupled to transmembrane movement of substancesGO:0426269.3ABCC2, ABCB11, ABCB4
3organic anion transmembrane transporter activityGO:0085149.0SLCO1A2, ABCC2
4ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityGO:0048798.7NR1H4, NR1I3, NR1I2
5transcription coactivator activityGO:0037138.7NR1H4, NR1I3, NR1I2

Products for genes affiliated with Intrahepatic Cholestasis of Pregnancy

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Intrahepatic Cholestasis of Pregnancy

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet