ICP
MCID: INT099
MIFTS: 49

Intrahepatic Cholestasis of Pregnancy (ICP) malady

Genetic diseases, Rare diseases, Reproductive diseases, Liver diseases categories
Download this MalaCard

Summaries for Intrahepatic Cholestasis of Pregnancy

About this section
Sources:
21Genetics Home Reference, 65Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard
Genetics Home Reference:21 Intrahepatic cholestasis of pregnancy is a liver disorder that occurs in pregnant women. Cholestasis is a condition that impairs the release of a digestive fluid called bile from liver cells. As a result, bile builds up in the liver, impairing liver function. Because the problems with bile release occur within the liver (intrahepatic), the condition is described as intrahepatic cholestasis. Intrahepatic cholestasis of pregnancy usually becomes apparent in the third trimester of pregnancy. Bile flow returns to normal after delivery of the baby, and the signs and symptoms of the condition disappear. However, they can return during later pregnancies.

MalaCards: Intrahepatic Cholestasis of Pregnancy, also known as recurrent intrahepatic cholestasis of pregnancy, is related to cholestasis and intrahepatic cholestasis. An important gene associated with Intrahepatic Cholestasis of Pregnancy is ABCB4 (ATP-binding cassette, sub-family B (MDR/TAP), member 4), and among its related pathways are Statin Pathway - Generalized, Pharmacokinetics and ABC-family proteins mediated transport. The compounds fusidic acid and gf 120918 have been mentioned in the context of this disorder. Affiliated tissues include placenta, liver and testes, and related mouse phenotypes are liver/biliary system and homeostasis/metabolism.

Wikipedia:65 Intrahepatic cholestasis of pregnancy (ICP), also known as obstetric cholestasis, cholestasis of... more...

Aliases & Classifications for Intrahepatic Cholestasis of Pregnancy

About this section
Sources:
43NIH Rare Diseases, 21Genetics Home Reference, 20GeneTests, 62UMLS
See all sources

Classifications:



Aliases & Descriptions:

intrahepatic cholestasis of pregnancy 43 21
recurrent intrahepatic cholestasis of pregnancy 43 21
familial intrahepatic cholestasis of pregnancy 43 20
familial recurrent intrahepatic cholestasis of pregnancy 43
cholestasis, intrahepatic of pregnancy 43
progressive intrahepatic cholestasis 62
pregnancy related cholestasis 43
pregnancy-related cholestasis 21
cholestasis of pregnancy 62
obstetric cholestasis 21
ricp 43
icp 43


Related Diseases for Intrahepatic Cholestasis of Pregnancy

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Cholestasis, Intrahepatic, of Pregnancy, 1 family:

intrahepatic cholestasis of pregnancy Cholestasis, Intrahepatic, of Pregnancy, 3

Diseases related to Intrahepatic Cholestasis of Pregnancy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 63)
idRelated DiseaseScoreTop Affiliating Genes
1cholestasis32.0ABCB11, ABCB4, NR1H4, NR1I3, ABCC2
2intrahepatic cholestasis32.0ABCB11, ABCB4, NR1H4, HLA-G, NR1I3, ABCC2
3breast cancer30.1ABCB4, NR1H4, ABCB11, ABCC2, HLA-G, NR1I3
4hepatitis10.6
5cholestasis, intrahepatic, of pregnancy, 110.6
6eclampsia10.4
7pre-eclampsia10.4
8viral hepatitis10.4
9benign recurrent intrahepatic cholestasis10.4
10hydrocephalus10.4
11cerebritis10.3
12intracranial hypertension10.3
13choledocholithiasis10.3
14steatorrhea10.3
15gestational diabetes10.3
16impetigo herpetiformis10.3
17diabetes mellitus10.3
18impetigo10.3
19liver disease10.3
20acute fatty liver of pregnancy10.3
21hypoxia10.3
22cholestasis, intrahepatic, of pregnancy, 310.3
23blindness10.3
24aneurysm10.3
25head injury10.2
26normal pressure hydrocephalus10.1
27brain compression10.1
28communicating hydrocephalus10.1
29brain injury10.1
30cerebral aneurysms10.1
31cholangitis10.1ABCB4
32cholestasis, progressive familial intrahepatic 210.1ABCB4, ABCB11
33cholestasis, progressive familial intrahepatic 310.1ABCB4, ABCB11
34cholelithiasis10.1ABCB4, ABCB11
35primary sclerosing cholangitis10.0ABCB4, ABCC2
36hepatitis c10.0ABCB4, ABCC2
37hepatoblastoma10.0ABCC2, NR1H4
38b-cell chronic lymphocytic leukemia10.0HLA-G, ABCB4
39cholestasis, progressive familial intrahepatic 110.0ABCB4, ABCB11, NR1H4
40galactosemia10.0ABCB11, ABCB4, NR1H4
41acute leukemia10.0HLA-G, ABCB4, ABCC2
42endometriosis10.0AHSG, HLA-G
43bilirubin metabolic disorder10.0NR1I3, ABCC2
44ovarian cancer10.0ABCB11, ABCC2, HLA-G
45uremia10.0AHSG, NR1I3
46ipex syndrome10.0ABCB11, ABCC2, HLA-G
47malignant glioma10.0ABCB4, ABCC2, HLA-G
48intracranial aneurysm10.0
49arachnoiditis10.0
50brain edema10.0

Graphical network of the top 20 diseases related to Intrahepatic Cholestasis of Pregnancy:



Diseases related to intrahepatic cholestasis of pregnancy

Symptoms for Intrahepatic Cholestasis of Pregnancy

About this section

Drugs & Therapeutics for Intrahepatic Cholestasis of Pregnancy

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials
See all sources

Drug clinical trials:

Search ClinicalTrials for Intrahepatic Cholestasis of Pregnancy

Search NIH Clinical Center for Intrahepatic Cholestasis of Pregnancy

Genetic Tests for Intrahepatic Cholestasis of Pregnancy

About this section
Sources:
20GeneTests
See all sources

Genetic tests related to Intrahepatic Cholestasis of Pregnancy:

id Genetic test Affiliating Genes
1 Cholestasis, Familial Intrahepatic, of Pregnancy20 ABCB4

Anatomical Context for Intrahepatic Cholestasis of Pregnancy

About this section
Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Intrahepatic Cholestasis of Pregnancy:

33
Placenta, Liver, Testes, Smooth muscle, Breast

Animal Models for Intrahepatic Cholestasis of Pregnancy or affiliated genes

About this section
Sources:
37MGI
See all sources

MGI Mouse Phenotypes related to Intrahepatic Cholestasis of Pregnancy:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053707.8NR1H4, NR1I3, ABCC2, ABCB11, ABCB4
2MP:00053766.4NR1H4, ABCB4, ABCB11, ABCC2, HLA-G, AHSG

Publications for Intrahepatic Cholestasis of Pregnancy

About this section
Sources:
52PubMed
See all sources

Articles related to Intrahepatic Cholestasis of Pregnancy:

(show top 50)    (show all 258)
idTitleAuthorsYear
1
Ursodeoxycholic acid in the treatment of intrahepatic cholestasis of pregnancy: a randomized controlled trial. (23978872)
2013
2
Primary bile acids as potential biomarkers for the clinical grading of intrahepatic cholestasis of pregnancy. (23562588)
2013
3
Study on the regulation of cell adhesion molecule expression and function in placenta from women with intrahepatic cholestasis of pregnancy. (23810461)
2013
4
Menopause after a history of intrahepatic cholestasis of pregnancy. (24149924)
2013
5
Intrahepatic cholestasis of pregnancy: correlation of preterm delivery with bile acids. (22287405)
2011
6
Pregnancy outcome in cases of intrahepatic cholestasis of pregnancy. (21247575)
2011
7
Bile acid signaling in fetal tissues: implications for intrahepatic cholestasis of pregnancy. (21691106)
2011
8
Relationship between umbilical artery Doppler waveform analysis and perinatal prognosis in women with intrahepatic cholestasis of pregnancy. (20705289)
2010
9
High mean platelet volume, low-grade systemic coagulation, and fibrinolytic activation are associated with pre-term delivery and low APGAR score in intrahepatic cholestasis of pregnancy. (20670095)
2010
10
Expression of HLA-G protein in placental tissues and its influence on Th1/Th2 cytokines in peripheral blood in patients with intrahepatic cholestasis of pregnancy]. (20360645)
2010
11
The influence of common gene variants of the xenobiotic receptor (PXR) in genetic susceptibility to intrahepatic cholestasis of pregnancy. (19958310)
2010
12
The c.504T>C (p.Asn168Asn) polymorphism in the ABCB4 gene as a predisposing factor for intrahepatic cholestasis of pregnancy in Greece. (19840247)
2010
13
Combined functional variants of hepatobiliary transporters and FXR aggravate intrahepatic cholestasis of pregnancy. (19490418)
2009
14
Contribution of variant alleles of ABCB11 to susceptibility to intrahepatic cholestasis of pregnancy. (18987030)
2009
15
Hepatobiliary phospholipid transporter ABCB4, MDR3 gene variants in a large cohort of Italian women with intrahepatic cholestasis of pregnancy. (18083082)
2008
16
Association of gene polymorphisms of CYP1B1 with intrahepatic cholestasis of pregnancy]. (18575334)
2008
17
Intrahepatic cholestasis of pregnancy in women with a multiple pregnancy: an analysis of risks and pregnancy outcomes. (19126282)
2008
18
Relationship of the occurrence of fetal distress and change of umbilical cord and expression of vasoactive substance in umbilical vein in intrahepatic cholestasis of pregnancy]. (18683743)
2008
19
Intrahepatic cholestasis of pregnancy: Amelioration of pruritus by UDCA is associated with decreased progesterone disulphates in urine. (17968976)
2008
20
Linkage between a new splicing site mutation in the MDR3 alias ABCB4 gene and intrahepatic cholestasis of pregnancy. (17187437)
2007
21
The importance of serum bile acid level analysis and treatment with ursodeoxycholic acid in intrahepatic cholestasis of pregnancy: a case series from central Europe. (17576942)
2007
22
Association between polymorphisms of CYP17 and CYP3A4 genes and intrahepatic cholestasis of pregnancy in Chengdu]. (16909599)
2006
23
Potential role of trans-inhibition of the bile salt export pump by progesterone metabolites in the etiopathogenesis of intrahepatic cholestasis of pregnancy. (16458994)
2006
24
Plasma lipid profiles of women with intrahepatic cholestasis of pregnancy. (16394047)
2006
25
Intrahepatic cholestasis of pregnancy as an indicator of liver and biliary diseases: a population-based study. (16557542)
2006
26
Intrahepatic cholestasis of pregnancy: Relationships between bile acid levels and fetal complication rates. (15368452)
2004
27
Diagnosis and therapy of intrahepatic cholestasis of pregnancy. (15248112)
2004
28
A second heterozygous MDR3 nonsense mutation associated with intrahepatic cholestasis of pregnancy. (12624161)
2003
29
ABCB4 gene sequence variation in women with intrahepatic cholestasis of pregnancy. (12746424)
2003
30
Intrahepatic cholestasis of pregnancy: review of the literature. (11773831)
2002
31
Intrahepatic cholestasis of pregnancy: what's new. (12224684)
2002
32
Ursodeoxycholic acid for the treatment of intrahepatic cholestasis of pregnancy. (11392594)
2001
33
Oral guar gum, a gel-forming dietary fiber relieves pruritus in intrahepatic cholestasis of pregnancy. (10746839)
2000
34
Intrahepatic cholestasis of pregnancy has no effect on maternal serum second trimester alpha-fetoprotein and hCG. (10929953)
2000
35
Apolipoprotein E alleles in women with intrahepatic cholestasis of pregnancy. (11063158)
2000
36
Bile acids and progesterone metabolites in intrahepatic cholestasis of pregnancy. (10766400)
2000
37
Intrahepatic cholestasis of pregnancy: a critical review. (11249293)
2000
38
Hepatitis G virus infection detected in a woman with intrahepatic cholestasis of pregnancy. (9890225)
1998
39
A randomised placebo-controlled trial of ursodeoxycholic acid and S-adenosylmethionine in the treatment of intrahepatic cholestasis of pregnancy. (9853771)
1998
40
Intrahepatic cholestasis of pregnancy. (9638904)
1998
41
Severe fetal intracranial haemorrhage during treatment with cholestyramine for intrahepatic cholestasis of pregnancy. (7756215)
1995
42
Serum conjugated bile acid profile during intrahepatic cholestasis of pregnancy. (7751589)
1995
43
Intrahepatic cholestasis of pregnancy. (7888831)
1994
44
Intrahepatic cholestasis of pregnancy: a retrospective case-control study of perinatal outcome. (8141222)
1994
45
Ursodeoxycholic acid treatment of intrahepatic cholestasis of pregnancy: observations on efficacy and safety. (8425713)
1993
46
Epomediol ameliorates pruritus in patients with intrahepatic cholestasis of pregnancy. (1484159)
1992
47
Intrahepatic cholestasis of pregnancy and acute fatty liver of pregnancy. An unusual but favorable association? (2001812)
1991
48
Serum copper in intrahepatic cholestasis of pregnancy. (1820694)
1991
49
S-adenosylmethionine for the treatment of intrahepatic cholestasis of pregnancy. Results of a controlled clinical trial. (2083923)
1990
50
Familial recurrent intrahepatic cholestasis of pregnancy: a genetic study providing evidence for transmission of a sex-limited, dominant trait. (6852450)
1983

Variations for Intrahepatic Cholestasis of Pregnancy

About this section
Sources:
1 National Center for Biotechnology Information (Clinvar)
See all sources

Clinvar genetic disease variations for Intrahepatic Cholestasis of Pregnancy:

1 (show all 12)
id Gene Name Type Significance SNP ID Assembly Location
1ATP8B1NM_005603.4(ATP8B1): c.1993G> T (p.Glu665Ter)single nucleotide variantPathogenicrs515726137GRCh37Chr 18, 55336654: 55336654
2ATP8B1NM_005603.4(ATP8B1): c.625C> A (p.Pro209Thr)single nucleotide variantPathogenicrs515726138GRCh38Chr 18, 57697797: 57697797
3ATP8B1NM_005603.4(ATP8B1): c.923G> T (p.Gly308Val)single nucleotide variantPathogenicrs111033609GRCh37Chr 18, 55362420: 55362420
4NM_005603.4(ATP8B1): c.2674G> A (p.Gly892Arg)single nucleotide variantPathogenicrs121909098GRCh37Chr 18, 55328439: 55328439
5ATP8B1NM_005603.4(ATP8B1): c.863T> C (p.Leu288Ser)single nucleotide variantPathogenicrs121909099GRCh37Chr 18, 55362480: 55362480
6ATP8B1NM_005603.4(ATP8B1): c.2097+2T> Csingle nucleotide variantPathogenicrs387906381GRCh37Chr 18, 55336548: 55336548
7ATP8B1NM_005603.4(ATP8B1): c.1982T> C (p.Ile661Thr)single nucleotide variantPathogenicrs121909100GRCh37Chr 18, 55336665: 55336665
8ATP8B1NM_005603.4(ATP8B1): c.1660G> A (p.Asp554Asn)single nucleotide variantPathogenicrs121909101GRCh37Chr 18, 55342225: 55342225
9ATP8B1NM_005603.4(ATP8B1): c.208G> A (p.Asp70Asn)single nucleotide variantPathogenicrs34719006GRCh37Chr 18, 55373793: 55373793
10NM_005603.4(ATP8B1): c.2599C> T (p.Arg867Cys)single nucleotide variantPathogenicrs121909103GRCh37Chr 18, 55328514: 55328514
11ATP8B1NM_005603.4(ATP8B1): c.1367C> T (p.Thr456Met)single nucleotide variantPathogenicrs121909104GRCh37Chr 18, 55355593: 55355593
12ATP8B1NM_005603.4(ATP8B1): c.1804C> T (p.Arg602Ter)single nucleotide variantPathogenicrs121909105GRCh37Chr 18, 55342081: 55342081

Expression for genes affiliated with Intrahepatic Cholestasis of Pregnancy

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Intrahepatic Cholestasis of Pregnancy

Search GEO for disease gene expression data for Intrahepatic Cholestasis of Pregnancy.

Pathways for genes affiliated with Intrahepatic Cholestasis of Pregnancy

About this section
Sources:
50PathCards, 51PharmGKB, 55Reactome, 30KEGG, 53QIAGEN, 38NCBI BioSystems Database
See all sources

Compounds for genes affiliated with Intrahepatic Cholestasis of Pregnancy

About this section
Sources:
45Novoseek, 11DrugBank, 51PharmGKB, 29IUPHAR, 61Tocris Bioscience, 24HMDB, 3BitterDB
See all sources

Compounds related to Intrahepatic Cholestasis of Pregnancy according to GeneCards/GeneDecks:

(show top 50)    (show all 74)
idCompoundScoreTop Affiliating Genes
1fusidic acid45 1111.0ABCC2, ABCB11
2gf 120918459.9ABCB11, ABCC2
3psc-833459.9ABCB11, ABCC2
4ly335979459.9ABCB11, ABCC2
5estradiol-17beta-glucuronide459.9ABCC2, ABCB4
6wort459.9ABCB11, ABCC2
7pluronic f127459.9ABCB11, ABCC2
8ethinyl estradiol51 1110.8ABCC2, ABCB11
9reserpine45 29 1111.8ABCB11, ABCC2
10gw 406461 4510.8NR1H4, ABCC2
11Taurocholic acid24 1110.7ABCC2, ABCB11
12cyclosporine51 1110.7ABCC2, ABCB11
13rifampin51 1110.7ABCB11, ABCC2
14glycocholate459.6ABCB4, ABCB11, ABCC2
15rhodamine 12345 5110.6ABCC2, ABCB11, ABCB4
16daunorubicin45 51 1111.6ABCB4, ABCB11, ABCC2
17vincristine45 51 1111.5ABCC2, ABCB11, ABCB4
18verapamil45 29 51 24 1113.5ABCB4, ABCB11, ABCC2
19adriamycin459.5ABCC2, ABCB11, ABCB4
20hyperforin29 45 1111.5ABCC2, NR1I3
21tacrolimus45 51 1111.5ABCC2, ABCB11, ABCB4
22saquinavir45 1110.4ABCC2, ABCB11
23cholic acid45 29 24 1112.4ABCB11, ABCC2, NR1H4
24etoposide45 51 61 1112.4ABCB4, ABCB11, ABCC2
25methotrexate51 45 1111.4HLA-G, ABCC2, ABCB4
26colchicine45 61 3 29 1113.3NR1I3, ABCB11, ABCB4
27deoxycholic acid45 29 24 1112.2NR1H4, ABCB11
28phospholipid459.2ABCB4, ABCB11, NR1H4
29lithocholic acid45 29 2411.2ABCB11, NR1I3, NR1H4
30phenytoin45 51 29 1112.1NR1I3, ABCC2, ABCB11
31steroidal459.1NR1H4, NR1I3
32rifampicin45 29 6111.1ABCB11, ABCC2, NR1I3
33phenobarbital45 29 51 1112.1NR1I3, ABCC2, ABCB11
34taurocholate459.1ABCB4, ABCB11, ABCC2, NR1H4
35ursodeoxycholic acid45 24 1111.1ABCB4, ABCB11, ABCC2, NR1H4
36androstane459.0NR1H4, NR1I3, ABCC2
37ribonucleic acid459.0NR1I3, HLA-G, ABCB11
38paclitaxel45 51 1110.8ABCB4, ABCB11, ABCC2, NR1I3
39cyclosporin a45 29 6110.7NR1I3, ABCC2, ABCB11, ABCB4
40oligonucleotide458.7NR1I3, HLA-G, ABCB11, ABCB4
41vitamin d458.6NR1H4, NR1I3, AHSG
42sodium45 249.5ABCC2, HLA-G, NR1I3, NR1H4
43retinoic acid45 249.4ABCB11, ABCC2, NR1I3, NR1H4
44cholesterol45 29 24 1111.3ABCB4, ABCB11, HLA-G, NR1I3, NR1H4
45chenodeoxycholic acid45 29 24 1111.3NR1H4, NR1I3, ABCC2, ABCB11, ABCB4
46progesterone45 29 61 24 1112.2NR1H4, NR1I3, HLA-G, ABCC2, ABCB11
47tyrosine457.9ABCB11, ABCC2, AHSG, NR1I3, NR1H4
48dexamethasone45 51 29 1110.8NR1H4, NR1I3, HLA-G, ABCC2, ABCB11, ABCB4
49lipid457.8ABCB4, ABCB11, ABCC2, HLA-G, NR1I3, NR1H4
50estrogen457.6ABCB4, ABCB11, ABCC2, AHSG, NR1I3, NR1H4

GO Terms for genes affiliated with Intrahepatic Cholestasis of Pregnancy

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Intrahepatic Cholestasis of Pregnancy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi membraneGO:0001399.2HLA-G, ABCB11, ABCB4
2intercellular canaliculusGO:0465819.1ABCC2, ABCB11, ABCB4
3apical plasma membraneGO:0163248.9ABCC2, ABCB11, ABCB4

Biological processes related to Intrahepatic Cholestasis of Pregnancy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1bile acid metabolic processGO:0082069.2ABCB11, NR1H4
2transportGO:0068109.2ABCC2, ABCB11, ABCB4
3transmembrane transportGO:0550859.2ABCC2, ABCB11, ABCB4
4intracellular receptor signaling pathwayGO:0305229.0NR1H4, NR1I3

Molecular functions related to Intrahepatic Cholestasis of Pregnancy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityGO:0048799.1NR1H4, NR1I3
2ATPase activity, coupled to transmembrane movement of substancesGO:0426269.1ABCC2, ABCB11, ABCB4
3thyroid hormone receptor activityGO:0048878.8NR1H4, NR1I3

Products for genes affiliated with Intrahepatic Cholestasis of Pregnancy

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Intrahepatic Cholestasis of Pregnancy

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet