MCID: INT004
MIFTS: 36

Intraneural Perineurioma

Categories: Rare diseases, Neuronal diseases, Cancer diseases

Aliases & Classifications for Intraneural Perineurioma

MalaCards integrated aliases for Intraneural Perineurioma:

Name: Intraneural Perineurioma 12 49 55 14 69

Classifications:

Orphanet: 55  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:4696
NCIt 46 C6911
SNOMED-CT 64 128795001
Orphanet 55 ORPHA100003
UMLS via Orphanet 70 C1370658
UMLS 69 C1370658

Summaries for Intraneural Perineurioma

MalaCards based summary : Intraneural Perineurioma is related to perineurioma and localized hypertrophic neuropathy. An important gene associated with Intraneural Perineurioma is SLC2A1 (Solute Carrier Family 2 Member 1), and among its related pathways/superpathways are Developmental Biology and Cytoskeletal Signaling. Affiliated tissues include tongue and skin, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 72 An intraneural perineurioma is a rare benign tumor within the sheath of a single nerve that grows but... more...

Related Diseases for Intraneural Perineurioma

Diseases related to Intraneural Perineurioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 183)
# Related Disease Score Top Affiliating Genes
1 perineurioma 32.0 MUC1 S100B SLC2A1
2 localized hypertrophic neuropathy 31.0 MUC1 S100B
3 sclerosing perineurioma 10.7 MUC1 S100B
4 intracranial cysts 10.6 MUC1 S100B
5 reticular perineurioma 10.6 MUC1 S100B
6 malignant iris melanoma 10.6 S100A1 S100B
7 eosinophilic variant of chromophobe renal cell carcinoma 10.6 S100A1 SLC2A1
8 non-functioning pituitary adenoma 10.6 MUC1 S100B
9 papillary tumor of the pineal region 10.6 MUC1 S100A1
10 ossifying fibromyxoid tumor 10.6 MUC1 S100B
11 fibrous meningioma 10.6 MUC1 S100B
12 chordoid meningioma 10.6 MUC1 S100B
13 myxofibrosarcoma 10.5 MUC1 S100B
14 frontal sinus inverted papilloma 10.5 KRT13 KRT5
15 frontal sinus cancer 10.5 KRT13 KRT5
16 syringocystadenoma papilliferum 10.5 MUC1 S100B
17 basal cell carcinoma, infundibulocystic 10.5 KRT10 KRT14
18 polymorphous low-grade adenocarcinoma 10.5 MUC1 S100A1 S100B
19 neurenteric cyst 10.5 KRT18 KRT8
20 aggressive digital papillary adenocarcinoma 10.5 MUC1 S100B
21 endosalpingiosis 10.5 KRT7 MUC1
22 glandular cystitis 10.5 KRT7 MUC1
23 epidermolysis bullosa simplex, autosomal recessive 1 10.5 KRT14 KRT5
24 parachordoma 10.5 KRT7 MUC1
25 ameloblastic carcinoma 10.5 KRT14 SLC2A1
26 epidermolysis bullosa simplex, localized 10.5 KRT14 KRT5
27 pleomorphic liposarcoma 10.5 KRT8 MUC1 S100B
28 lichen planopilaris 10.4 KRT14 KRT5
29 vulvar intraepithelial neoplasia 10.4 KRT10 KRT7
30 endolymphatic sac tumor 10.4 KRT7 KRT8
31 schneiderian carcinoma 10.4 KRT18 KRT5
32 chordoid glioma 10.4 MUC1 S100B
33 malignant mixed mullerian tumor 10.4 KRT7 MUC1
34 epidermolysis bullosa simplex, generalized 10.4 KRT14 KRT5
35 pleomorphic adenoma 10.4 KRT14 MUC1 S100B
36 malignant triton tumor 10.4 NF1 S100B
37 mucinous bronchioloalveolar adenocarcinoma 10.4 KRT7 MUC1
38 inverted transitional papilloma 10.4 KRT5 KRT7
39 primary cutaneous anaplastic large cell lymphoma 10.4 ALK MUC1
40 myxopapillary ependymoma 10.4 MUC1 S100B
41 eccrine porocarcinoma 10.4 KRT7 MUC1 S100B
42 balloon cell malignant melanoma 10.4 KRT5 KRT7
43 alk-positive anaplastic large cell lymphoma 10.4 ALK MUC1
44 monophasic synovial sarcoma 10.4 KRT7 MUC1 S100B
45 spindle cell sarcoma 10.4 KRT7 MUC1 S100B
46 bile duct cystadenocarcinoma 10.4 KRT7 MUC1
47 orbital granuloma 10.4 CD34 MUC1
48 malignant spiradenoma 10.4 KRT5 KRT7
49 oncocytic breast carcinoma 10.4 KRT14 KRT7
50 sensory organ benign neoplasm 10.4 KRT5 KRT7

Graphical network of the top 20 diseases related to Intraneural Perineurioma:



Diseases related to Intraneural Perineurioma

Symptoms & Phenotypes for Intraneural Perineurioma

GenomeRNAi Phenotypes related to Intraneural Perineurioma according to GeneCards Suite gene sharing:

25 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.58 KRT5
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-154 9.58 KRT18
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-17 9.58 KRT18 KRT5
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.58 KRT5 KRT8
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.58 KRT5
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.58 KRT18
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.58 KRT8
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.58 KRT7
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.58 KRT8 KRT18 KRT5 KRT7
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.58 KRT7
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.58 KRT18
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.58 KRT5 KRT7

MGI Mouse Phenotypes related to Intraneural Perineurioma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.56 ALK CD34 KRT14 KRT19 KRT5 NF1
2 neoplasm MP:0002006 9.1 ALK CD34 KRT14 KRT19 NF1 SOX10

Drugs & Therapeutics for Intraneural Perineurioma

Search Clinical Trials , NIH Clinical Center for Intraneural Perineurioma

Genetic Tests for Intraneural Perineurioma

Anatomical Context for Intraneural Perineurioma

MalaCards organs/tissues related to Intraneural Perineurioma:

38
Tongue, Skin

Publications for Intraneural Perineurioma

Articles related to Intraneural Perineurioma:

(show all 45)
# Title Authors Year
1
Genomic analysis reveals frequent TRAF7 mutations in intraneural perineuriomas. ( 28019650 )
2017
2
Teaching NeuroImages: Sonographic detection of intraneural perineurioma in therapy-refractory carpal tunnel syndrome. ( 28265045 )
2017
3
Anesthesia for a parturient with intraneural perineurioma: A case report. ( 29245354 )
2017
4
Case report: Intraneural perineurioma of the sciatic nerve in an adolescent - strategies for revealing the diagnosis. ( 27525083 )
2016
5
Intratemporal Intraneural Perineurioma of the Facial Nerve. ( 27668794 )
2016
6
Nerve ultrasound and 3D-MR neurography suggestive of intraneural perineurioma. ( 27001989 )
2016
7
Intraneural perineurioma of the digital nerve: a case report. ( 26115680 )
2015
8
Intraneural Perineurioma of the Skin. ( 24999546 )
2014
9
Intraneural perineurioma affecting multiple nerves: a case report and literature review. ( 25031759 )
2014
10
Distinctive manifestations of cutaneous intraneural perineurioma of fingers, compared with typical intraneural perineurioma. ( 24685866 )
2014
11
Surgical removal of intraneural perineurioma arising in the brachial plexus using an interfascicular dissection technique. ( 24883285 )
2014
12
Cutaneous intraneural perineurioma: a case report. ( 23221470 )
2013
13
Intraneural perineurioma of the sciatic nerve: An under-recognized nerve neoplasm with characteristic MRI findings. ( 24061494 )
2013
14
Intraneural perineurioma of unilateral radial and median nerves manifesting with long-standing focal amyotrophy in a 14-year-old-boy. ( 24263031 )
2013
15
Hybrid schwannoma/perineurioma of the spinal nerve: multifocal occurrence, and recurrence as an intraneural perineurioma. ( 23865576 )
2013
16
Intraneural perineurioma arising in the lateral border of the tongue. ( 24422960 )
2013
17
MRI of intraneural perineurioma of the brachial plexus. ( 27326273 )
2012
18
Claudin-1 and glucose transporter 1 immunolabelling in a canine intraneural perineurioma. ( 22297071 )
2012
19
Mini-invasive robot-assisted surgery of the brachial plexus: a case of intraneural perineurioma. ( 22638873 )
2012
20
A case of intraneural perineurioma presenting with monomelic atrophy in a child. ( 20004070 )
2010
21
Intraneural perineurioma of the median nerve: case report and literature review. ( 19876692 )
2010
22
Intraneural perineurioma of the sciatic nerve in early childhood. ( 19520281 )
2009
23
Longitudinal study of intraneural perineurioma--a benign, focal hypertrophic neuropathy of youth. ( 19567701 )
2009
24
Oral intraneural perineurioma. Report of two cases. ( 19841714 )
2009
25
Intraneural perineurioma. ( 19766004 )
2009
26
Re: intraneural perineurioma of the median nerve. A rare cause of carpal tunnel syndrome. ( 18332033 )
2008
27
Intraneural perineurioma: a systematic review with illustrative cases. ( 17824794 )
2007
28
Intraneural perineurioma of the radial nerve visualized by 3.0 Tesla MRI. ( 17471567 )
2007
29
Multiple orofacial intraneural perineuriomas in a patient with hemifacial hyperplasia. ( 17449293 )
2007
30
Intraneural perineurioma of the VIIIth cranial nerve: case report. ( 17881938 )
2007
31
Intraneural perineurioma of the oral mucosa. ( 16757071 )
2007
32
Intraneural perineurioma of the third cranial nerve: occurrence and identification. Case report. ( 16703891 )
2006
33
Intraneural perineurioma of the tongue: a case report. ( 16781350 )
2006
34
Canine intraneural perineurioma. ( 16407486 )
2006
35
Intraneural perineurioma of the radial nerve in a child. ( 16039379 )
2005
36
Intraneural perineurioma in a child with Beckwith-Wiedemann syndrome. ( 15750909 )
2005
37
Intraosseous intraneural perineurioma: report of a case with morphological, immunohistochemical and FISH study. ( 14704619 )
2004
38
Radial nerve palsy owing to localized hypertrophic neuropathy (intraneural perineurioma) in early childhood. ( 15032391 )
2004
39
Intraneural perineurioma involving the ulnar nerve. ( 15086844 )
2004
40
Bilateral intraneural perineurioma presenting as ulnar neuropathy at the elbow. ( 15266642 )
2004
41
Intraneural perineurioma--not restricted to major nerves. ( 12931092 )
2003
42
Carpal tunnel syndrome due to an intraneural perineurioma in a 2-year-old child. ( 11281674 )
2001
43
Intraneural perineurioma of the common peroneal nerve. Case report and review of the literature. ( 11354415 )
2001
44
Intraneural perineurioma involving the median nerve. ( 10839408 )
2000
45
Intraneural perineurioma. A clonal neoplasm associated with abnormalities of chromosome 22. ( 7785653 )
1995

Variations for Intraneural Perineurioma

Expression for Intraneural Perineurioma

Search GEO for disease gene expression data for Intraneural Perineurioma.

Pathways for Intraneural Perineurioma

Pathways related to Intraneural Perineurioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.12 KRT10 KRT13 KRT14 KRT18 KRT19 KRT5
2 12.25 KRT10 KRT13 KRT18 KRT19 KRT5 KRT7
3
Show member pathways
12.01 KRT10 KRT13 KRT14 KRT18 KRT19 KRT5
4 11.4 S100B SLC2A1 SOX10
5
Show member pathways
11.2 KRT13 KRT14 KRT18 KRT19 KRT5 KRT7

GO Terms for Intraneural Perineurioma

Cellular components related to Intraneural Perineurioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Z disc GO:0030018 9.62 KRT19 KRT8 S100A1 SLC2A1
2 sarcolemma GO:0042383 9.58 KRT19 KRT8 SLC2A1
3 cell periphery GO:0071944 9.55 CD34 KRT14 KRT18 KRT19 KRT8
4 costamere GO:0043034 9.48 KRT19 KRT8
5 dystrophin-associated glycoprotein complex GO:0016010 9.43 KRT19 KRT8
6 keratin filament GO:0045095 9.43 KRT13 KRT14 KRT18 KRT5 KRT7 KRT8
7 intermediate filament GO:0005882 9.23 KRT10 KRT13 KRT14 KRT18 KRT19 KRT5
8 nucleus GO:0005634 10.27 KRT10 KRT13 KRT14 KRT18 KRT5 KRT7
9 cytoplasm GO:0005737 10.21 CD34 KRT10 KRT14 KRT18 KRT5 KRT7
10 extracellular exosome GO:0070062 10 ALK KRT10 KRT13 KRT14 KRT18 KRT19

Biological processes related to Intraneural Perineurioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.56 KRT10 KRT13 KRT14 KRT18 KRT19 KRT5
2 positive regulation of myelination GO:0031643 9.37 S100B SOX10
3 hemidesmosome assembly GO:0031581 9.32 KRT14 KRT5
4 hepatocyte apoptotic process GO:0097284 9.26 KRT18 KRT8
5 cornification GO:0070268 9.23 KRT10 KRT13 KRT14 KRT18 KRT19 KRT5
6 cell differentiation involved in embryonic placenta development GO:0060706 9.16 KRT19 KRT8

Molecular functions related to Intraneural Perineurioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 9.43 KRT14 KRT19 KRT5
2 S100 protein binding GO:0044548 9.16 S100A1 S100B
3 scaffold protein binding GO:0097110 9.13 KRT18 KRT5 KRT8
4 structural molecule activity GO:0005198 9.02 KRT10 KRT13 KRT18 KRT7 KRT8

Sources for Intraneural Perineurioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
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41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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