MCID: INT054
MIFTS: 50

Intraocular Lymphoma malady

Eye diseases, Blood diseases, Cancer diseases, Rare diseases, Immune diseases categories

Aliases & Classifications for Intraocular Lymphoma

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Intraocular Lymphoma, Aliases & Descriptions:

Name: Intraocular Lymphoma 30 9 11 43 60
Primary Intraocular Lymphoma 9 47
Primary Intraocular Non-Hodgkin Malignant Lymphoma 60
 
Primary Intraocular Non-Hodgkin's Lymphoma 47
Piol 47


Classifications:



Characteristics (Orphanet epidemiological data):

47
primary intraocular lymphoma:
Inheritance: Not applicable; Age of onset: Adult; Age of death: elderly


External Ids:

Disease Ontology9 DOID:775
NCIt38 C9184
Orphanet47 279904

Summaries for Intraocular Lymphoma

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Wikipedia:63 Intraocular lymphoma is a rare malignant form of eye cancer. Intraocular lymphoma may affect the eye... more...

MalaCards based summary: Intraocular Lymphoma, also known as primary intraocular lymphoma, is related to uveitis and systemic lupus erythematosus. An important gene associated with Intraocular Lymphoma is IL10 (interleukin 10), and among its related pathways are Syndecan-4-mediated signaling events and Signaling by Slit. The compounds cyclam and bicyclam have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and b cells, and related mouse phenotypes are craniofacial and liver/biliary system.

Related Diseases for Intraocular Lymphoma

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Diseases related to Intraocular Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 92)
idRelated DiseaseScoreTop Affiliating Genes
1uveitis30.5IL4, IL10, CXCR5
2systemic lupus erythematosus29.9IL10, CXCR5, IL4
3retinitis10.5
4central nervous system lymphoma10.3
5central nervous system lymphoma, primary10.3BCL6, CXCR5
6folic acid deficiency anemia10.3SLC19A1, FOLR1
7precursor b-cell acute lymphoblastic leukemia10.3CXCR5, CXCR4
8whim syndrome10.3CXCR4, CXCL12
9aids dementia complex10.3CXCR4, CXCL12
10plasmacytoma10.2BCL6, CXCR5
11mantle cell lymphoma10.2BCL2, BCL6
12lymphosarcoma10.2BCL6, BCL2
13chorioretinitis10.2
14panuveitis10.2
15cytomegalovirus retinitis10.2
16periodontitis10.2IL10, CXCR4
17burkitt lymphoma10.2BCL2, BCL6
18selective iga deficiency disease10.2IL10, IL4
19lepromatous leprosy10.2IL10, IL4
20visceral leishmaniasis10.1IL10, IL4
21reticulosarcoma10.1BCL2, BCL6
22cutaneous leishmaniasis10.1IL4, IL10
23malt lymphoma10.1CXCR5, BCL6, BCL2
24acute graft versus host disease10.1IL10, IL4
25follicular lymphoma10.1BCL2, BCL6, CXCR5
26common variable immunodeficiency10.1IL10, IL4
27hyperopia10.1
28diabetes mellitus, insulin-dependent10.1IL10, IL4
29leishmaniasis10.1IL10, IL4
30neural tube defects10.1FOLR1, SLC19A1
31b-cell lymphomas10.1CXCR5, BCL2, BCL6
32testicular lymphoma10.0
33acquired immunodeficiency syndrome10.0
34orbit lymphoma10.0
35retinal vasculitis10.0
36choroiditis10.0
37cerebritis10.0
38cerebral lymphoma10.0
39breast lymphoma10.0
40temporal arteritis10.0
41endophthalmitis10.0
42hypopyon10.0
43lupus erythematosus10.0
44meningitis10.0
45sarcoma10.0
46vasculitis10.0
47multifocal choroiditis10.0
48blindness10.0
49schistosomiasis10.0IL10, IL4
50vascular disease10.0BCL2, CXCL12, IL10

Graphical network of the top 20 diseases related to Intraocular Lymphoma:



Diseases related to intraocular lymphoma

Symptoms for Intraocular Lymphoma

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Drugs & Therapeutics for Intraocular Lymphoma

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Drug clinical trials:

Search ClinicalTrials for Intraocular Lymphoma

Search NIH Clinical Center for Intraocular Lymphoma

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Intraocular Lymphoma cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Intraocular Lymphoma:
Hematopoietic stem cells for treatment of hematologic malignancies
Embryonic/Adult Cultured Cells Related to Intraocular Lymphoma:
Bone marrow-derived hematopoietic stem cells

Genetic Tests for Intraocular Lymphoma

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Anatomical Context for Intraocular Lymphoma

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MalaCards organs/tissues related to Intraocular Lymphoma:

31
Brain, Eye, B cells, Retina, Bone, T cells, Colon, Breast, Hypothalamus

Animal Models for Intraocular Lymphoma or affiliated genes

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Publications for Intraocular Lymphoma

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Articles related to Intraocular Lymphoma:

(show top 50)    (show all 176)
idTitleAuthorsYear
1
Intraocular lymphoma: a clinical perspective. (23196650)
2013
2
Current concepts in diagnosing and managing primary vitreoretinal (intraocular) lymphoma. (23449111)
2013
3
Primary intraocular lymphoma: treatment outcomes with ocular radiation therapy alone. (23822539)
2013
4
Secondary orbital and intraocular lymphoma treated with immunochemotherapy. (25391121)
2013
5
Unilateral retinopathy secondary to occult primary intraocular lymphoma. (24081663)
2013
6
Birdshot retinochoroidopathy masquerading as intraocular lymphoma. (22594959)
2012
7
Retinal optical coherence tomography manifestations of intraocular lymphoma. (22477623)
2012
8
Spontaneous regression of intraocular lymphoma. (22551603)
2012
9
Clinical features and diagnostic significance of the intraocular fluid of 217 patients with intraocular lymphoma. (22661396)
2012
10
Enucleation of painful blind eye for refractory intraocular lymphoma after dose-limiting chemotherapy and radiotherapy. (22450776)
2012
11
Subretinal lymphomatous infiltration in primary intraocular lymphoma revealed by optical coherence tomography. (21509532)
2011
12
Concurrent administration of intravenous systemic and intravitreal methotrexate for intraocular lymphoma with central nervous system involvement. (20464643)
2010
13
Fundus autofluorescence patterns in eyes with primary intraocular lymphoma. (19834356)
2010
14
25-Gauge transconjunctival sutureless vitrectomy for the diagnosis of intraocular lymphoma. (20447965)
2010
15
Diagnosis of intraocular lymphoma by polymerase chain reaction analysis and cytokine profiling of the vitreous fluid. (19484437)
2009
16
Primary intraocular lymphoma. (19653715)
2009
17
Primary intraocular lymphoma: diagnosis and differential diagnosis. (19585354)
2009
18
Ocular tuberculoma mimicking intraocular lymphoma. (19412865)
2009
19
Ifosfamide or trofosfamide in patients with intraocular lymphoma. (19099202)
2009
20
Successful use of semi-nested PCR for the diagnosis of primary intraocular lymphoma. (18608860)
2008
21
Intraocular lymphoma following a primary testicular lymphoma in remission for 10 years. (17985076)
2008
22
IL-10 measurement in aqueous humor for screening patients with suspicion of primary intraocular lymphoma. (17591896)
2007
23
Primary intraocular lymphoma mimicking multifocal choroiditis and panuveitis. (17304253)
2007
24
Ocular masquerade syndrome due to intraocular lymphoma--two forms of retinal pigment epithelium involvement: case reports. (17768564)
2007
25
An Asian patient with intraocular lymphoma treated by intravitreal methotrexate. (17013703)
2006
26
Detection of the bcl-2 t(14;18) translocation and proto-oncogene expression in primary intraocular lymphoma. (16799010)
2006
27
Anterior chamber paracentesis cytology (cytospin technique) for the diagnosis of intraocular lymphoma. (16488933)
2006
28
Intraocular lymphoma 2000-2005: results of a retrospective multicentre trial. (16228920)
2006
29
Primary intraocular lymphoma: current and future perspectives. (17064977)
2006
30
Murine model of primary intraocular lymphoma. (15671263)
2005
31
Molecular pathology of primary intraocular lymphoma. (14971583)
2003
32
Evaluation of vitrectomy specimens and chorioretinal biopsies in the diagnosis of primary intraocular lymphoma in patients with Masquerade syndrome. (14605902)
2003
33
Pseudo-hypopyon as the presenting feature in B-cell and T-cell intraocular lymphoma. (12648051)
2003
34
Variations in the presentation of primary intraocular lymphoma: case reports and a review. (11425352)
2001
35
Primary intraocular lymphoma with a low interleukin 10 to interleukin 6 ratio and heterogeneous IgH gene rearrangement. (10496399)
1999
36
Use of the polymerase chain reaction to detect B- and T-cell gene rearrangements in vitreous specimens from patients with intraocular lymphoma. (10369586)
1999
37
Using interleukin 10 to interleukin 6 ratio to distinguish primary intraocular lymphoma and uveitis. (10476821)
1999
38
Intravitreal chemotherapy for the treatment of recurrent intraocular lymphoma. (10434868)
1999
39
Intraocular Lymphoma. (10761081)
1998
40
Diagnosis of intraocular lymphoma by polymerase chain reaction. (9248839)
1997
41
ECT in a patient receiving prophylactic CNS irradiation for an intraocular lymphoma. (8701020)
1996
42
Interleukin-10 in the vitreous of patients with primary intraocular lymphoma. (7485372)
1995
43
Intraocular lymphoma presenting as retinal vasculitis. (7801221)
1994
44
Intraocular lymphoma invades the optic nerve and orbit. (8427488)
1993
45
Intraocular lymphoma. Clinical and histopathologic diagnosis. (8371930)
1993
46
Presumed intraocular lymphoma in a 60-year-old man with AIDS. (1490092)
1992
47
Intraocular lymphoma: clinical presentations, differential diagnosis and treatment. (2631302)
1989
48
Solitary intraocular lymphoma as an initial presentation of widespread disease. (2647068)
1989
49
Chemotherapy in the management of intraocular lymphoma. (2702565)
1989
50
Treatment of intraocular lymphoma with high-dose Ara-C. (2418934)
1986

Variations for Intraocular Lymphoma

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Expression for genes affiliated with Intraocular Lymphoma

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Search GEO for disease gene expression data for Intraocular Lymphoma.

Pathways for genes affiliated with Intraocular Lymphoma

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Pathways related to Intraocular Lymphoma according to GeneCards Suite gene sharing:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CXCR4, CXCL12
29.8CXCR4, CXCL12
3
Show member pathways
S1P2 pathway36
S1P4 pathway36
S1P5 pathway36
S1P1 pathway36
Sphingosine 1-phosphate (S1P) pathway36
9.7CXCR4, ABCC1
49.7IL4, IL10
59.7IL10, IL4
69.6SLC19A1, ABCC1
7
Show member pathways
9.6BCL2, IL10
89.4BCL2, ABCC1
9
Show member pathways
IL2 signaling events mediated by STAT536
9.3BCL2, IL4
10
Show member pathways
9.3SLC19A1, FOLR1, ABCC1
119.1IL4, IL10, BCL6
12
Show member pathways
Apoptosis and survival BAD phosphorylation58
Development Alpha 2 adrenergic receptor activation of ERK58
Chemotaxis CXCR4 signaling pathway58
9.1BCL2, CXCR4, CXCL12
139.0IL4, IL10, BCL2
14
Show member pathways
9.0IL4, IL10, BCL2
15
Show member pathways
9.0CXCL12, CXCR4, IL4, IL10
16
Show member pathways
8.9CXCR4, CXCL12, CXCR5
17
Show member pathways
8.9CXCR5, CXCL12, CXCR4
188.7BCL6, IL10, IL4, CXCL12
19
Show member pathways
8.3CXCL12, CXCR4, IL4, IL10, BCL2
20
Show member pathways
8.3CXCL12, CXCR4, IL4, IL10, BCL2
21
Show member pathways
8.3CXCL12, CXCR4, IL4, IL10, BCL2
22
Show member pathways
8.3CXCL12, CXCR4, IL4, IL10, BCL2
23
Show member pathways
7.5CXCR5, CXCL12, CXCR4, IL4, IL10, BCL2

Compounds for genes affiliated with Intraocular Lymphoma

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Compounds related to Intraocular Lymphoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 105)
idCompoundScoreTop Affiliating Genes
1cyclam4310.1CXCR4, CXCL12
2bicyclam4310.1CXCR4, CXCL12
3plerixafor43 28 1212.1CXCR4, CXCL12
4n-hydroxysuccinimide4310.1SLC19A1, FOLR1
5monomethyl fumarate4310.0IL4, IL10
6lometrexol4310.0SLC19A1, FOLR1
7betaseron439.9IL4, IL10
8sdf 1439.9CXCR4, CXCL12
91843u89439.9ABCC1, SLC19A1
10mdms439.9CXCR4, CXCL12, IL10
11acidophilus439.8IL4, IL10
12ccl343 2810.8IL10, CXCL12, CXCR4
13tomudex439.7ABCC1, FOLR1, SLC19A1
14interferon gamma439.7IL4, IL10
15trimetrexate43 1210.7FOLR1, SLC19A1
16anaphylatoxin439.6IL4, CXCL12, CXCR4
17montelukast43 49 28 1212.6IL4, ABCC1, IL10
18lamivudine43 49 1211.6IL10, IL4, ABCC1
19zidovudine43 49 1211.4IL10, CXCR4, CXCL12, ABCC1
205-aza-2deoxycytidine439.4CXCR4, FOLR1, SLC19A1, CXCL12
21probenecid28 43 59 49 1213.4SLC19A1, FOLR1, C19orf48, ABCC1
22ibuprofen43 28 49 24 1213.4IL10, BCL2, ABCC1
23tarc439.4IL4, IL10, CXCL12, CXCR4
24quinine43 28 2 49 1213.4IL10, IL4, CXCR4, CXCL12
25methotrexate49 43 1211.4IL10, SLC19A1, FOLR1, ABCC1
26daunorubicin43 49 1211.4C19orf48, BCL2, ABCC1
27chloroquine43 2 49 28 1213.3IL10, IL4, ABCC1
28carboplatin43 49 1211.1BCL2, SLC19A1, CXCR4, ABCC1
29rapamycin439.1CXCL12, CXCR4, IL10, BCL2
30rituximab43 49 1211.1BCL2, BCL6, IL10, CXCL12
31cyclosporin a43 28 5911.0IL10, C19orf48, IL4, CXCR4, ABCC1
325fluorouracil439.0SLC19A1, BCL2, CXCL12, ABCC1
33vincristine43 49 1210.9BCL2, BCL6, SLC19A1, ABCC1
34thymidylate438.8SLC19A1, BCL2, IL10, FOLR1, ABCC1
35gemcitabine43 49 1210.8ABCC1, IL10, BCL2
36paclitaxel43 49 1210.8BCL2, ABCC1, FOLR1, CXCR4, SLC19A1
37sb 20358043 599.8BCL2, CXCR4, IL4, IL10, CXCL12
38ly294002438.7BCL2, IL10, IL4, CXCL12, CXCR4
39dexamethasone43 49 28 1211.7IL4, CXCL12, IL10, BCL2, CXCR4
40vegf438.6BCL2, CXCL12, IL10, CXCR4, IL4
41paraffin438.6IL10, BCL2, IL4, BCL6
42actinomycin d438.6ABCC1, CXCL12, CXCR4, IL4, BCL2
43rantes438.6IL4, CXCR5, CXCL12, IL10, CXCR4
44cisplatin43 49 59 1211.5C19orf48, FOLR1, BCL2, CXCR4, ABCC1, SLC19A1
45estrogen438.3BCL2, C19orf48, CXCL12, CXCR4, BCL6
46doxorubicin43 49 1210.3SLC19A1, ABCC1, C19orf48, FOLR1, BCL6, BCL2
47cyclophosphamide43 49 1210.3CXCR4, CXCL12, IL4, IL10, BCL6, BCL2
48cycloheximide438.2IL4, CXCL12, CXCR4, IL10, BCL6, BCL2
49serine438.1CXCL12, BCL6, FOLR1, CXCR4, BCL2, SLC19A1
50imatinib43 49 129.8CXCR4, BCL6, IL10, IL4, BCL2, CXCL12

GO Terms for genes affiliated with Intraocular Lymphoma

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Cellular components related to Intraocular Lymphoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098978.9IL4, CXCR4, CXCL12
2membraneGO:00160208.7SLC19A1, BCL2, FOLR1, ABCC1

Biological processes related to Intraocular Lymphoma according to GeneCards Suite gene sharing:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1ameboidal cell migrationGO:000166710.1CXCR4, CXCL12
2folic acid transportGO:001588410.1FOLR1, SLC19A1
3folic acid metabolic processGO:004665510.1SLC19A1, FOLR1
4germ cell migrationGO:000835410.0CXCL12, CXCR4
5T cell proliferationGO:004209810.0CXCR4, CXCL12
6regulation of isotype switchingGO:004519110.0IL4, IL10
7motor neuron axon guidanceGO:000804510.0CXCR4, CXCL12
8positive regulation of MHC class II biosynthetic processGO:004534810.0IL10, IL4
9chemokine-mediated signaling pathwayGO:007009810.0CXCR4, CXCL12
10negative regulation of nitric oxide biosynthetic processGO:004501910.0IL4, IL10
11germ cell developmentGO:00072819.9CXCL12, CXCR4
12patterning of blood vesselsGO:00015699.9CXCR4, CXCL12
13B cell proliferationGO:00421009.7BCL2, IL10
14regulation of calcium ion transportGO:00519249.7CXCL12, BCL2
15response to radiationGO:00093149.7BCL2, CXCL12
16type 2 immune responseGO:00420929.5BCL6, IL10, IL4
17B cell differentiationGO:00301839.5BCL6, IL10, IL4
18extrinsic apoptotic signaling pathway in absence of ligandGO:00971929.4BCL2, IL4
19inflammatory responseGO:00069549.4BCL6, IL10, CXCR4
20response to cytokineGO:00340979.3BCL2, IL4
21positive regulation of B cell proliferationGO:00308909.2BCL2, BCL6, IL4
22chemotaxisGO:00069359.0IL4, CXCL12, CXCR5
23response to drugGO:00424938.9ABCC1, IL4, IL10, BCL2
24G-protein coupled receptor signaling pathwayGO:00071868.8CXCR5, CXCL12, CXCR4
25immune responseGO:00069558.4IL4, CXCL12, CXCR5

Molecular functions related to Intraocular Lymphoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1folic acid transporter activityGO:00085179.8SLC19A1, FOLR1
2folic acid bindingGO:00055429.5SLC19A1, FOLR1
3growth factor activityGO:00080839.3IL10, IL4, CXCL12
4C-X-C chemokine receptor activityGO:00164949.3CXCR4, CXCR5

Products for genes affiliated with Intraocular Lymphoma

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  • Antibodies
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  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Intraocular Lymphoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet