PIOL
MCID: INT054
MIFTS: 58

Intraocular Lymphoma (PIOL) malady

Eye diseases, Blood diseases, Cancer diseases, Rare diseases, Immune diseases categories
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Summaries for Intraocular Lymphoma

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65Wikipedia, 33MalaCards
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Wikipedia:65 Intraocular lymphoma is a rare malignant form of eye cancer. Intraocular lymphoma may affect the eye... more...

MalaCards: Intraocular Lymphoma, also known as primary intraocular lymphoma, is related to uveitis and systemic lupus erythematosus. An important gene associated with Intraocular Lymphoma is IL10 (interleukin 10), and among its related pathways are Syndecan-4-mediated signaling events and Signaling by Slit. The compounds cyclam and bicyclam have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and b cells, and related mouse phenotypes are craniofacial and liver/biliary system.

Aliases & Classifications for Intraocular Lymphoma

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8Disease Ontology, 10DISEASES, 45Novoseek, 31LifeMap Discovery™, 62UMLS, 49Orphanet, 40NCIt, 59SNOMED-CT via Orphanet
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Classifications:



Characteristics (Orphanet epidemiological data):

49
primary intraocular lymphoma:
Inheritance: Sporadic; Age of onset: Adulthood; Age of death: Elderly


Aliases & Descriptions:

intraocular lymphoma 8 10 45 31 62
primary intraocular lymphoma 8 49
primary intraocular non-hodgkin's lymphoma 49
piol 49


External Ids:

Disease Ontology8 DOID:775
NCIt40 C9184
SNOMED-CT via Orphanet59 420788006

Related Diseases for Intraocular Lymphoma

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17GeneCards, 18GeneDecks
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Diseases related to Intraocular Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 99)
idRelated DiseaseScoreTop Affiliating Genes
1uveitis30.4IL4, IL10, CXCR5
2systemic lupus erythematosus30.0IL10, CXCR5, IL4
3retinitis10.5
4central nervous system lymphoma10.3
5chorioretinitis10.2
6hodgkin's lymphoma10.2
7panuveitis10.2
8cytomegalovirus retinitis10.2
9central nervous system lymphoma, primary10.1BCL6, CXCR5
10hyperopia10.1
11folic acid deficiency anemia10.1SLC19A1, FOLR1
12whim syndrome10.1CXCR4, CXCL12
13leukemia, acute lymphoblastic 310.1CXCR5, CXCR4
14aids dementia complex10.1CXCR4, CXCL12
15plasmacytoma10.1BCL6, CXCR5
16mantle cell lymphoma10.1BCL2, BCL6
17lymphosarcoma10.0BCL6, BCL2
18lymphoma, diffuse large cell10.0BCL6, BCL2
19periodontitis10.0IL10, CXCR4
20burkitt's lymphoma10.0BCL2, BCL6
21selective iga deficiency disease10.0IL10, IL4
22lepromatous leprosy10.0IL10, IL4
23visceral leishmaniasis10.0IL10, IL4
24acquired immunodeficiency syndrome10.0
25orbit lymphoma10.0
26retinal vasculitis10.0
27choroiditis10.0
28cerebritis10.0
29testicular lymphoma10.0
30breast lymphoma10.0
31cerebral lymphoma10.0
32temporal arteritis10.0
33endophthalmitis10.0
34hypopyon10.0
35lupus erythematosus10.0
36meningitis10.0
37sarcoidosis10.0
38sarcoma10.0
39vasculitis10.0
40multifocal choroiditis10.0
41blindness10.0
42lymphomatous meningitis10.0
43cutaneous leishmaniasis10.0IL4, IL10
44reticulosarcoma10.0BCL2, BCL6
45immunodeficiency, common variable, 710.0IL10, IL4
46malt lymphoma10.0CXCR5, BCL6, BCL2
47acute graft versus host disease10.0IL10, IL4
48follicular lymphoma10.0BCL2, BCL6, CXCR5
49common variable immune deficiency10.0IL10, IL4
50sepsis10.0CXCR4, IL10, CXCL12

Graphical network of the top 20 diseases related to Intraocular Lymphoma:



Diseases related to intraocular lymphoma

Symptoms for Intraocular Lymphoma

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Drugs & Therapeutics for Intraocular Lymphoma

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Intraocular Lymphoma

Search NIH Clinical Center for Intraocular Lymphoma

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Intraocular Lymphoma cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Intraocular Lymphoma:
Hematopoietic stem cells for treatment of hematologic malignancies
Embryonic/Adult Cultured Cells Related to Intraocular Lymphoma:
Bone marrow-derived hematopoietic stem cells

Genetic Tests for Intraocular Lymphoma

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Anatomical Context for Intraocular Lymphoma

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33MalaCards
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MalaCards organs/tissues related to Intraocular Lymphoma:

33
Brain, Eye, B cells, Retina, Bone, T cells, Colon, Breast, Hypothalamus

Animal Models for Intraocular Lymphoma or affiliated genes

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Sources:
37MGI
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Publications for Intraocular Lymphoma

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Sources:
52PubMed
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Articles related to Intraocular Lymphoma:

(show top 50)    (show all 166)
idTitleAuthorsYear
1
Intraocular lymphoma: a clinical perspective. (23196650)
2013
2
Current concepts in diagnosing and managing primary vitreoretinal (intraocular) lymphoma. (23449111)
2013
3
Primary intraocular lymphoma: treatment outcomes with ocular radiation therapy alone. (23822539)
2013
4
Unilateral retinopathy secondary to occult primary intraocular lymphoma. (24081663)
2013
5
Birdshot retinochoroidopathy masquerading as intraocular lymphoma. (22594959)
2012
6
Retinal optical coherence tomography manifestations of intraocular lymphoma. (22477623)
2012
7
Spontaneous regression of intraocular lymphoma. (22551603)
2012
8
Clinical features and diagnostic significance of the intraocular fluid of 217 patients with intraocular lymphoma. (22661396)
2012
9
Enucleation of painful blind eye for refractory intraocular lymphoma after dose-limiting chemotherapy and radiotherapy. (22450776)
2012
10
Evaluation of the reactive T-cell infiltrate in uveitis and intraocular lymphoma with flow cytometry of vitreous fluid (an American Ophthalmological Society thesis). (23818738)
2012
11
Subretinal lymphomatous infiltration in primary intraocular lymphoma revealed by optical coherence tomography. (21509532)
2011
12
Primary intraocular lymphoma: a review. (21626069)
2011
13
Concurrent administration of intravenous systemic and intravitreal methotrexate for intraocular lymphoma with central nervous system involvement. (20464643)
2010
14
Fundus autofluorescence patterns in eyes with primary intraocular lymphoma. (19834356)
2010
15
25-Gauge transconjunctival sutureless vitrectomy for the diagnosis of intraocular lymphoma. (20447965)
2010
16
Diagnosis of intraocular lymphoma by polymerase chain reaction analysis and cytokine profiling of the vitreous fluid. (19484437)
2009
17
Primary intraocular lymphoma. (19653715)
2009
18
Primary intraocular lymphoma: diagnosis and differential diagnosis. (19585354)
2009
19
Ocular tuberculoma mimicking intraocular lymphoma. (19412865)
2009
20
Ifosfamide or trofosfamide in patients with intraocular lymphoma. (19099202)
2009
21
Successful use of semi-nested PCR for the diagnosis of primary intraocular lymphoma. (18608860)
2008
22
Intraocular lymphoma following a primary testicular lymphoma in remission for 10 years. (17985076)
2008
23
IL-10 measurement in aqueous humor for screening patients with suspicion of primary intraocular lymphoma. (17591896)
2007
24
Primary intraocular lymphoma mimicking multifocal choroiditis and panuveitis. (17304253)
2007
25
Ocular masquerade syndrome due to intraocular lymphoma--two forms of retinal pigment epithelium involvement: case reports. (17768564)
2007
26
An Asian patient with intraocular lymphoma treated by intravitreal methotrexate. (17013703)
2006
27
Detection of the bcl-2 t(14;18) translocation and proto-oncogene expression in primary intraocular lymphoma. (16799010)
2006
28
Anterior chamber paracentesis cytology (cytospin technique) for the diagnosis of intraocular lymphoma. (16488933)
2006
29
Intraocular lymphoma 2000-2005: results of a retrospective multicentre trial. (16228920)
2006
30
Primary intraocular lymphoma: current and future perspectives. (17064977)
2006
31
Murine model of primary intraocular lymphoma. (15671263)
2005
32
Molecular pathology of primary intraocular lymphoma. (14971583)
2003
33
Evaluation of vitrectomy specimens and chorioretinal biopsies in the diagnosis of primary intraocular lymphoma in patients with Masquerade syndrome. (14605902)
2003
34
Pseudo-hypopyon as the presenting feature in B-cell and T-cell intraocular lymphoma. (12648051)
2003
35
Variations in the presentation of primary intraocular lymphoma: case reports and a review. (11425352)
2001
36
Primary intraocular lymphoma with a low interleukin 10 to interleukin 6 ratio and heterogeneous IgH gene rearrangement. (10496399)
1999
37
Use of the polymerase chain reaction to detect B- and T-cell gene rearrangements in vitreous specimens from patients with intraocular lymphoma. (10369586)
1999
38
Using interleukin 10 to interleukin 6 ratio to distinguish primary intraocular lymphoma and uveitis. (10476821)
1999
39
Intravitreal chemotherapy for the treatment of recurrent intraocular lymphoma. (10434868)
1999
40
Intraocular Lymphoma. (10761081)
1998
41
Diagnosis of intraocular lymphoma by polymerase chain reaction. (9248839)
1997
42
ECT in a patient receiving prophylactic CNS irradiation for an intraocular lymphoma. (8701020)
1996
43
Interleukin-10 in the vitreous of patients with primary intraocular lymphoma. (7485372)
1995
44
Intraocular lymphoma presenting as retinal vasculitis. (7801221)
1994
45
Intraocular lymphoma. Clinical and histopathologic diagnosis. (8371930)
1993
46
Presumed intraocular lymphoma in a 60-year-old man with AIDS. (1490092)
1992
47
Intraocular lymphoma: clinical presentations, differential diagnosis and treatment. (2631302)
1989
48
Solitary intraocular lymphoma as an initial presentation of widespread disease. (2647068)
1989
49
Chemotherapy in the management of intraocular lymphoma. (2702565)
1989
50
Treatment of intraocular lymphoma with high-dose Ara-C. (2418934)
1986

Variations for Intraocular Lymphoma

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Expression for genes affiliated with Intraocular Lymphoma

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Intraocular Lymphoma

Search GEO for disease gene expression data for Intraocular Lymphoma.

Pathways for genes affiliated with Intraocular Lymphoma

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Sources:
50PathCards, 38NCBI BioSystems Database, 53QIAGEN, 30KEGG, 54R&D Systems, 51PharmGKB, 12EMD Millipore, 60Thomson Reuters, 55Reactome, 5Cell Signaling Technology
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Pathways related to Intraocular Lymphoma according to GeneCards/GeneDecks:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CXCR4, CXCL12
29.8CXCR4, CXCL12
3
Show member pathways
S1P2 pathway38
S1P4 pathway38
S1P5 pathway38
S1P1 pathway38
Sphingosine 1-phosphate (S1P) pathway38
9.7CXCR4, ABCC1
49.7IL4, IL10
59.7IL10, IL4
69.6SLC19A1, ABCC1
7
Show member pathways
9.6BCL2, IL10
89.4BCL2, ABCC1
9
Show member pathways
IL2 signaling events mediated by STAT538
9.3BCL2, IL4
109.3BCL2, BCL6
11
Show member pathways
9.3SLC19A1, FOLR1, ABCC1
129.1IL4, IL10, BCL6
13
Show member pathways
Apoptosis and survival BAD phosphorylation60
Development Alpha 2 adrenergic receptor activation of ERK60
Chemotaxis CXCR4 signaling pathway60
9.1BCL2, CXCR4, CXCL12
149.0IL4, IL10, BCL2
15
Show member pathways
9.0IL4, IL10, BCL2
16
Show member pathways
9.0CXCL12, CXCR4, IL4, IL10
17
Show member pathways
8.9CXCR4, CXCL12, CXCR5
18
Show member pathways
8.9CXCR5, CXCL12, CXCR4
198.7BCL6, IL10, IL4, CXCL12
20
Show member pathways
8.3CXCL12, CXCR4, IL4, IL10, BCL2
21
Show member pathways
8.3CXCL12, CXCR4, IL4, IL10, BCL2
22
Show member pathways
8.3CXCL12, CXCR4, IL4, IL10, BCL2
23
Show member pathways
8.3CXCL12, CXCR4, IL4, IL10, BCL2
24
Show member pathways
7.5CXCR5, CXCL12, CXCR4, IL4, IL10, BCL2

Compounds for genes affiliated with Intraocular Lymphoma

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Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 51PharmGKB, 61Tocris Bioscience, 24HMDB, 3BitterDB
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Compounds related to Intraocular Lymphoma according to GeneCards/GeneDecks:

(show top 50)    (show all 105)
idCompoundScoreTop Affiliating Genes
1cyclam4510.1CXCR4, CXCL12
2bicyclam4510.1CXCR4, CXCL12
3plerixafor45 29 1112.1CXCR4, CXCL12
4n-hydroxysuccinimide4510.1SLC19A1, FOLR1
5monomethyl fumarate4510.0IL4, IL10
6lometrexol4510.0SLC19A1, FOLR1
7betaseron459.9IL4, IL10
8sdf 1459.9CXCR4, CXCL12
91843u89459.9ABCC1, SLC19A1
10mdms459.9CXCR4, CXCL12, IL10
11acidophilus459.8IL4, IL10
12ccl345 2910.8IL10, CXCL12, CXCR4
13tomudex459.7ABCC1, FOLR1, SLC19A1
14interferon gamma459.7IL4, IL10
15trimetrexate45 1110.7FOLR1, SLC19A1
16anaphylatoxin459.6IL4, CXCL12, CXCR4
17montelukast45 51 29 1112.6IL4, ABCC1, IL10
18lamivudine45 51 1111.6IL10, IL4, ABCC1
19zidovudine45 51 1111.4IL10, CXCR4, CXCL12, ABCC1
205-aza-2deoxycytidine459.4CXCR4, FOLR1, SLC19A1, CXCL12
21probenecid29 45 61 51 1113.4SLC19A1, FOLR1, C19orf48, ABCC1
22ibuprofen45 29 51 24 1113.4IL10, BCL2, ABCC1
23tarc459.4IL4, IL10, CXCL12, CXCR4
24quinine45 29 3 51 1113.4IL10, IL4, CXCR4, CXCL12
25methotrexate51 45 1111.4IL10, SLC19A1, FOLR1, ABCC1
26daunorubicin45 51 1111.4C19orf48, BCL2, ABCC1
27chloroquine45 3 51 29 1113.3IL10, IL4, ABCC1
28carboplatin45 51 1111.1BCL2, SLC19A1, CXCR4, ABCC1
29rapamycin459.1CXCL12, CXCR4, IL10, BCL2
30rituximab45 51 1111.1BCL2, BCL6, IL10, CXCL12
31cyclosporin a45 29 6111.0IL10, C19orf48, IL4, CXCR4, ABCC1
325fluorouracil459.0SLC19A1, BCL2, CXCL12, ABCC1
33vincristine45 51 1110.9BCL2, BCL6, SLC19A1, ABCC1
34thymidylate458.8SLC19A1, BCL2, IL10, FOLR1, ABCC1
35gemcitabine45 51 1110.8ABCC1, IL10, BCL2
36paclitaxel45 51 1110.8BCL2, ABCC1, FOLR1, CXCR4, SLC19A1
37sb 20358045 619.8BCL2, CXCR4, IL4, IL10, CXCL12
38ly294002458.7BCL2, IL10, IL4, CXCL12, CXCR4
39dexamethasone45 51 29 1111.7IL4, CXCL12, IL10, BCL2, CXCR4
40vegf458.6BCL2, CXCL12, IL10, CXCR4, IL4
41paraffin458.6IL10, BCL2, IL4, BCL6
42actinomycin d458.6ABCC1, CXCL12, CXCR4, IL4, BCL2
43rantes458.6IL4, CXCR5, CXCL12, IL10, CXCR4
44cisplatin45 51 61 1111.5C19orf48, FOLR1, BCL2, CXCR4, ABCC1, SLC19A1
45estrogen458.3BCL2, C19orf48, CXCL12, CXCR4, BCL6
46doxorubicin45 51 1110.3SLC19A1, ABCC1, C19orf48, FOLR1, BCL6, BCL2
47cyclophosphamide45 51 1110.3CXCR4, CXCL12, IL4, IL10, BCL6, BCL2
48cycloheximide458.2IL4, CXCL12, CXCR4, IL10, BCL6, BCL2
49serine458.1CXCL12, BCL6, FOLR1, CXCR4, BCL2, SLC19A1
50imatinib45 51 119.8CXCR4, BCL6, IL10, IL4, BCL2, CXCL12

GO Terms for genes affiliated with Intraocular Lymphoma

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Sources:
16Gene Ontology
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Cellular components related to Intraocular Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.9IL4, CXCR4, CXCL12
2membraneGO:0160208.7SLC19A1, BCL2, FOLR1, ABCC1

Biological processes related to Intraocular Lymphoma according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1ameboidal cell migrationGO:00166710.1CXCR4, CXCL12
2folic acid transportGO:01588410.1FOLR1, SLC19A1
3folic acid metabolic processGO:04665510.1SLC19A1, FOLR1
4germ cell migrationGO:00835410.0CXCL12, CXCR4
5T cell proliferationGO:04209810.0CXCR4, CXCL12
6regulation of isotype switchingGO:04519110.0IL4, IL10
7motor neuron axon guidanceGO:00804510.0CXCR4, CXCL12
8positive regulation of MHC class II biosynthetic processGO:04534810.0IL10, IL4
9chemokine-mediated signaling pathwayGO:07009810.0CXCR4, CXCL12
10negative regulation of nitric oxide biosynthetic processGO:04501910.0IL4, IL10
11germ cell developmentGO:0072819.9CXCL12, CXCR4
12patterning of blood vesselsGO:0015699.9CXCR4, CXCL12
13B cell proliferationGO:0421009.7BCL2, IL10
14regulation of calcium ion transportGO:0519249.7CXCL12, BCL2
15response to radiationGO:0093149.7BCL2, CXCL12
16type 2 immune responseGO:0420929.5BCL6, IL10, IL4
17B cell differentiationGO:0301839.5BCL6, IL10, IL4
18extrinsic apoptotic signaling pathway in absence of ligandGO:0971929.4BCL2, IL4
19inflammatory responseGO:0069549.4BCL6, IL10, CXCR4
20response to cytokineGO:0340979.3BCL2, IL4
21positive regulation of B cell proliferationGO:0308909.2BCL2, BCL6, IL4
22chemotaxisGO:0069359.0IL4, CXCL12, CXCR5
23response to drugGO:0424938.9ABCC1, IL4, IL10, BCL2
24G-protein coupled receptor signaling pathwayGO:0071868.8CXCR5, CXCL12, CXCR4
25immune responseGO:0069558.4IL4, CXCL12, CXCR5

Molecular functions related to Intraocular Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1folic acid transporter activityGO:0085179.8SLC19A1, FOLR1
2folic acid bindingGO:0055429.5SLC19A1, FOLR1
3growth factor activityGO:0080839.3IL10, IL4, CXCL12
4C-X-C chemokine receptor activityGO:0164949.3CXCR4, CXCR5

Products for genes affiliated with Intraocular Lymphoma

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  • Antibodies
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  • Lysates
  • Antibodies

Sources for Intraocular Lymphoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet