PIOL
MCID: INT054
MIFTS: 58

Intraocular Lymphoma (PIOL) malady

Eye diseases, Blood diseases, Cancer diseases, Rare diseases, Immune diseases categories
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Summaries for Intraocular Lymphoma

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Wikipedia:65 Intraocular lymphoma is a rare malignant form of eye cancer. Intraocular lymphoma may affect the eye... more...

MalaCards based summary: Intraocular Lymphoma, also known as primary intraocular lymphoma, is related to uveitis and systemic lupus erythematosus. An important gene associated with Intraocular Lymphoma is IL10 (interleukin 10), and among its related pathways are Syndecan-4-mediated signaling events and Signaling by Slit. The compounds cyclam and bicyclam have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and b cells, and related mouse phenotypes are craniofacial and liver/biliary system.

Aliases & Classifications for Intraocular Lymphoma

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Intraocular Lymphoma, Aliases & Descriptions:

Name: Intraocular Lymphoma 30 8 10 44 62
Primary Intraocular Lymphoma 8 48 62
 
Primary Intraocular Non-Hodgkin's Lymphoma 48
Piol 48


Classifications:



Characteristics (Orphanet epidemiological data):

48
primary intraocular lymphoma:
Inheritance: Sporadic; Age of onset: Adulthood; Age of death: Elderly


External Ids:

Disease Ontology8 DOID:775
NCIt39 C9184

Related Diseases for Intraocular Lymphoma

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Diseases related to Intraocular Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 97)
idRelated DiseaseScoreTop Affiliating Genes
1uveitis30.5IL10, IL4, CXCR5
2systemic lupus erythematosus29.9CXCR5, IL4, IL10
3retinitis10.5
4central nervous system lymphoma10.3
5central nervous system lymphoma, primary10.3BCL6, CXCR5
6leukemia, acute lymphoblastic 310.3CXCR5, CXCR4
7folic acid deficiency anemia10.3FOLR1, SLC19A1
8whim syndrome10.3CXCL12, CXCR4
9aids dementia complex10.3CXCL12, CXCR4
10plasmacytoma10.2CXCR5, BCL6
11mantle cell lymphoma10.2BCL6, BCL2
12lymphosarcoma10.2BCL6, BCL2
13hodgkin's lymphoma10.2
14chorioretinitis10.2
15panuveitis10.2
16cytomegalovirus retinitis10.2
17periodontitis10.2IL10, CXCR4
18burkitt's lymphoma10.2BCL2, BCL6
19selective iga deficiency disease10.2IL10, IL4
20lepromatous leprosy10.2IL4, IL10
21visceral leishmaniasis10.2IL10, IL4
22cutaneous leishmaniasis10.1IL4, IL10
23reticulosarcoma10.1BCL6, BCL2
24spina bifida10.1FOLR1, SLC19A1
25malt lymphoma10.1CXCR5, BCL6, BCL2
26acute graft versus host disease10.1IL10, IL4
27follicular lymphoma10.1CXCR5, BCL6, BCL2
28common variable immunodeficiency10.1IL10, IL4
29sepsis10.1CXCL12, CXCR4, IL10
30type 1 diabetes mellitus10.1IL10, IL4
31leishmaniasis10.1IL4, IL10
32hyperopia10.1
33b-cell lymphomas10.1BCL2, BCL6, CXCR5
34schistosomiasis10.1IL10, IL4
35testicular lymphoma10.0
36acquired immunodeficiency syndrome10.0
37cerebral lymphoma10.0
38breast lymphoma10.0
39temporal arteritis10.0
40orbit lymphoma10.0
41retinal vasculitis10.0
42choroiditis10.0
43cerebritis10.0
44endophthalmitis10.0
45hypopyon10.0
46lupus erythematosus10.0
47meningitis10.0
48sarcoidosis10.0
49sarcoma10.0
50vasculitis10.0

Graphical network of the top 20 diseases related to Intraocular Lymphoma:



Diseases related to intraocular lymphoma

Symptoms for Intraocular Lymphoma

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Drugs & Therapeutics for Intraocular Lymphoma

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Drug clinical trials:

Search ClinicalTrials for Intraocular Lymphoma

Search NIH Clinical Center for Intraocular Lymphoma

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Intraocular Lymphoma cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Intraocular Lymphoma:
Hematopoietic stem cells for treatment of hematologic malignancies
Embryonic/Adult Cultured Cells Related to Intraocular Lymphoma:
Bone marrow-derived hematopoietic stem cells

Genetic Tests for Intraocular Lymphoma

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Anatomical Context for Intraocular Lymphoma

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MalaCards organs/tissues related to Intraocular Lymphoma:

32
Brain, Eye, B cells, Retina, Bone, T cells, Colon, Breast, Hypothalamus

Animal Models for Intraocular Lymphoma or affiliated genes

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Publications for Intraocular Lymphoma

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Articles related to Intraocular Lymphoma:

(show top 50)    (show all 176)
idTitleAuthorsYear
1
Intraocular lymphoma: a clinical perspective. (23196650)
2013
2
Current concepts in diagnosing and managing primary vitreoretinal (intraocular) lymphoma. (23449111)
2013
3
Primary intraocular lymphoma: treatment outcomes with ocular radiation therapy alone. (23822539)
2013
4
Secondary orbital and intraocular lymphoma treated with immunochemotherapy. (25391121)
2013
5
Unilateral retinopathy secondary to occult primary intraocular lymphoma. (24081663)
2013
6
Birdshot retinochoroidopathy masquerading as intraocular lymphoma. (22594959)
2012
7
Retinal optical coherence tomography manifestations of intraocular lymphoma. (22477623)
2012
8
Spontaneous regression of intraocular lymphoma. (22551603)
2012
9
Clinical features and diagnostic significance of the intraocular fluid of 217 patients with intraocular lymphoma. (22661396)
2012
10
Enucleation of painful blind eye for refractory intraocular lymphoma after dose-limiting chemotherapy and radiotherapy. (22450776)
2012
11
Subretinal lymphomatous infiltration in primary intraocular lymphoma revealed by optical coherence tomography. (21509532)
2011
12
Concurrent administration of intravenous systemic and intravitreal methotrexate for intraocular lymphoma with central nervous system involvement. (20464643)
2010
13
Fundus autofluorescence patterns in eyes with primary intraocular lymphoma. (19834356)
2010
14
25-Gauge transconjunctival sutureless vitrectomy for the diagnosis of intraocular lymphoma. (20447965)
2010
15
Diagnosis of intraocular lymphoma by polymerase chain reaction analysis and cytokine profiling of the vitreous fluid. (19484437)
2009
16
Primary intraocular lymphoma. (19653715)
2009
17
Primary intraocular lymphoma: diagnosis and differential diagnosis. (19585354)
2009
18
Ocular tuberculoma mimicking intraocular lymphoma. (19412865)
2009
19
Ifosfamide or trofosfamide in patients with intraocular lymphoma. (19099202)
2009
20
Successful use of semi-nested PCR for the diagnosis of primary intraocular lymphoma. (18608860)
2008
21
Intraocular lymphoma following a primary testicular lymphoma in remission for 10 years. (17985076)
2008
22
IL-10 measurement in aqueous humor for screening patients with suspicion of primary intraocular lymphoma. (17591896)
2007
23
Primary intraocular lymphoma mimicking multifocal choroiditis and panuveitis. (17304253)
2007
24
Ocular masquerade syndrome due to intraocular lymphoma--two forms of retinal pigment epithelium involvement: case reports. (17768564)
2007
25
An Asian patient with intraocular lymphoma treated by intravitreal methotrexate. (17013703)
2006
26
Detection of the bcl-2 t(14;18) translocation and proto-oncogene expression in primary intraocular lymphoma. (16799010)
2006
27
Anterior chamber paracentesis cytology (cytospin technique) for the diagnosis of intraocular lymphoma. (16488933)
2006
28
Intraocular lymphoma 2000-2005: results of a retrospective multicentre trial. (16228920)
2006
29
Primary intraocular lymphoma: current and future perspectives. (17064977)
2006
30
Murine model of primary intraocular lymphoma. (15671263)
2005
31
Molecular pathology of primary intraocular lymphoma. (14971583)
2003
32
Evaluation of vitrectomy specimens and chorioretinal biopsies in the diagnosis of primary intraocular lymphoma in patients with Masquerade syndrome. (14605902)
2003
33
Pseudo-hypopyon as the presenting feature in B-cell and T-cell intraocular lymphoma. (12648051)
2003
34
Variations in the presentation of primary intraocular lymphoma: case reports and a review. (11425352)
2001
35
Primary intraocular lymphoma with a low interleukin 10 to interleukin 6 ratio and heterogeneous IgH gene rearrangement. (10496399)
1999
36
Use of the polymerase chain reaction to detect B- and T-cell gene rearrangements in vitreous specimens from patients with intraocular lymphoma. (10369586)
1999
37
Using interleukin 10 to interleukin 6 ratio to distinguish primary intraocular lymphoma and uveitis. (10476821)
1999
38
Intravitreal chemotherapy for the treatment of recurrent intraocular lymphoma. (10434868)
1999
39
Intraocular Lymphoma. (10761081)
1998
40
Diagnosis of intraocular lymphoma by polymerase chain reaction. (9248839)
1997
41
ECT in a patient receiving prophylactic CNS irradiation for an intraocular lymphoma. (8701020)
1996
42
Interleukin-10 in the vitreous of patients with primary intraocular lymphoma. (7485372)
1995
43
Intraocular lymphoma presenting as retinal vasculitis. (7801221)
1994
44
Intraocular lymphoma invades the optic nerve and orbit. (8427488)
1993
45
Intraocular lymphoma. Clinical and histopathologic diagnosis. (8371930)
1993
46
Presumed intraocular lymphoma in a 60-year-old man with AIDS. (1490092)
1992
47
Intraocular lymphoma: clinical presentations, differential diagnosis and treatment. (2631302)
1989
48
Solitary intraocular lymphoma as an initial presentation of widespread disease. (2647068)
1989
49
Chemotherapy in the management of intraocular lymphoma. (2702565)
1989
50
Treatment of intraocular lymphoma with high-dose Ara-C. (2418934)
1986

Variations for Intraocular Lymphoma

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Expression for genes affiliated with Intraocular Lymphoma

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Expression patterns in normal tissues for genes affiliated with Intraocular Lymphoma

Search GEO for disease gene expression data for Intraocular Lymphoma.

Pathways for genes affiliated with Intraocular Lymphoma

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Pathways related to Intraocular Lymphoma according to GeneCards/GeneDecks:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CXCR4, CXCL12
29.8CXCR4, CXCL12
3
Show member pathways
S1P2 pathway37
S1P4 pathway37
S1P5 pathway37
S1P1 pathway37
Sphingosine 1-phosphate (S1P) pathway37
9.7CXCR4, ABCC1
49.7IL4, IL10
59.7IL10, IL4
69.6SLC19A1, ABCC1
7
Show member pathways
9.6BCL2, IL10
89.4BCL2, ABCC1
9
Show member pathways
IL2 signaling events mediated by STAT537
9.3BCL2, IL4
109.3BCL2, BCL6
11
Show member pathways
9.3SLC19A1, FOLR1, ABCC1
129.1IL4, IL10, BCL6
13
Show member pathways
Apoptosis and survival BAD phosphorylation60
Development Alpha 2 adrenergic receptor activation of ERK60
Chemotaxis CXCR4 signaling pathway60
9.1BCL2, CXCR4, CXCL12
149.0IL4, IL10, BCL2
15
Show member pathways
9.0IL4, IL10, BCL2
16
Show member pathways
9.0CXCL12, CXCR4, IL4, IL10
17
Show member pathways
8.9CXCR4, CXCL12, CXCR5
18
Show member pathways
8.9CXCR5, CXCL12, CXCR4
198.7BCL6, IL10, IL4, CXCL12
20
Show member pathways
8.3CXCL12, CXCR4, IL4, IL10, BCL2
21
Show member pathways
8.3CXCL12, CXCR4, IL4, IL10, BCL2
22
Show member pathways
8.3CXCL12, CXCR4, IL4, IL10, BCL2
23
Show member pathways
8.3CXCL12, CXCR4, IL4, IL10, BCL2
24
Show member pathways
7.5CXCR5, CXCL12, CXCR4, IL4, IL10, BCL2

Compounds for genes affiliated with Intraocular Lymphoma

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Compounds related to Intraocular Lymphoma according to GeneCards/GeneDecks:

(show top 50)    (show all 105)
idCompoundScoreTop Affiliating Genes
1cyclam4410.1CXCR4, CXCL12
2bicyclam4410.1CXCL12, CXCR4
3plerixafor44 28 1112.1CXCL12, CXCR4
4n-hydroxysuccinimide4410.1FOLR1, SLC19A1
5monomethyl fumarate4410.0IL10, IL4
6lometrexol4410.0FOLR1, SLC19A1
7sdf 1449.9CXCL12, CXCR4
8betaseron449.9IL4, IL10
9mdms449.9IL10, CXCR4, CXCL12
101843u89449.9ABCC1, SLC19A1
11acidophilus449.8IL4, IL10
12ccl344 2810.8IL10, CXCR4, CXCL12
13trimetrexate44 1110.8SLC19A1, FOLR1
14tomudex449.7SLC19A1, FOLR1, ABCC1
15anaphylatoxin449.6CXCL12, CXCR4, IL4
16montelukast44 50 28 1112.6IL10, IL4, ABCC1
17lamivudine44 50 1111.6ABCC1, IL4, IL10
18interferon gamma449.6IL10, IL4
19zidovudine44 50 1111.4IL10, CXCR4, CXCL12, ABCC1
205-aza-2deoxycytidine449.4CXCL12, CXCR4, FOLR1, SLC19A1
21probenecid28 44 61 50 1113.4ABCC1, C19orf48, FOLR1, SLC19A1
22ibuprofen44 28 50 24 1113.4BCL2, IL10, ABCC1
23tarc449.4IL10, IL4, CXCR4, CXCL12
24quinine44 28 2 50 1113.4CXCL12, CXCR4, IL4, IL10
25methotrexate50 44 1111.4ABCC1, FOLR1, IL10, SLC19A1
26daunorubicin44 50 1111.4ABCC1, C19orf48, BCL2
27chloroquine44 2 50 28 1113.3IL10, IL4, ABCC1
28carboplatin44 50 1111.1ABCC1, CXCR4, BCL2, SLC19A1
29rapamycin449.1CXCL12, CXCR4, IL10, BCL2
30rituximab44 50 1111.1CXCL12, IL10, BCL6, BCL2
31cyclosporin a44 28 6111.0ABCC1, C19orf48, CXCR4, IL4, IL10
325fluorouracil449.0SLC19A1, BCL2, CXCL12, ABCC1
33vincristine44 50 1110.9ABCC1, BCL6, BCL2, SLC19A1
34thymidylate448.8ABCC1, FOLR1, IL10, BCL2, SLC19A1
35gemcitabine44 50 1110.8ABCC1, IL10, BCL2
36paclitaxel44 50 1110.8ABCC1, CXCR4, FOLR1, BCL2, SLC19A1
37sb 20358044 619.8CXCL12, CXCR4, IL4, IL10, BCL2
38ly294002448.7CXCL12, CXCR4, IL4, IL10, BCL2
39dexamethasone44 50 28 1111.7CXCL12, CXCR4, IL4, IL10, BCL2
40vegf448.6CXCL12, CXCR4, IL4, IL10, BCL2
41paraffin448.6IL4, IL10, BCL6, BCL2
42actinomycin d448.6ABCC1, CXCL12, CXCR4, IL4, BCL2
43rantes448.6CXCR5, CXCL12, CXCR4, IL4, IL10
44cisplatin44 50 61 1111.5ABCC1, C19orf48, CXCR4, FOLR1, BCL2, SLC19A1
45estrogen448.3BCL2, BCL6, CXCR4, CXCL12, C19orf48
46doxorubicin44 50 1110.3ABCC1, C19orf48, FOLR1, BCL6, BCL2, SLC19A1
47cyclophosphamide44 50 1110.3CXCL12, CXCR4, IL4, IL10, BCL6, BCL2
48cycloheximide448.2CXCL12, CXCR4, IL4, IL10, BCL6, BCL2
49serine448.1CXCL12, CXCR4, FOLR1, BCL6, BCL2, SLC19A1
50imatinib44 50 119.8BCL2, ABCC1, CXCL12, CXCR4, IL4, IL10

GO Terms for genes affiliated with Intraocular Lymphoma

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Cellular components related to Intraocular Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.9IL4, CXCR4, CXCL12
2membraneGO:0160208.7SLC19A1, BCL2, FOLR1, ABCC1

Biological processes related to Intraocular Lymphoma according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1ameboidal cell migrationGO:00166710.1CXCR4, CXCL12
2folic acid transportGO:01588410.1FOLR1, SLC19A1
3folic acid metabolic processGO:04665510.1SLC19A1, FOLR1
4germ cell migrationGO:00835410.0CXCL12, CXCR4
5T cell proliferationGO:04209810.0CXCR4, CXCL12
6regulation of isotype switchingGO:04519110.0IL4, IL10
7motor neuron axon guidanceGO:00804510.0CXCR4, CXCL12
8positive regulation of MHC class II biosynthetic processGO:04534810.0IL10, IL4
9chemokine-mediated signaling pathwayGO:07009810.0CXCR4, CXCL12
10negative regulation of nitric oxide biosynthetic processGO:04501910.0IL4, IL10
11germ cell developmentGO:0072819.9CXCL12, CXCR4
12patterning of blood vesselsGO:0015699.9CXCR4, CXCL12
13B cell proliferationGO:0421009.7BCL2, IL10
14regulation of calcium ion transportGO:0519249.7CXCL12, BCL2
15response to radiationGO:0093149.7BCL2, CXCL12
16type 2 immune responseGO:0420929.5BCL6, IL10, IL4
17B cell differentiationGO:0301839.5BCL6, IL10, IL4
18extrinsic apoptotic signaling pathway in absence of ligandGO:0971929.4BCL2, IL4
19inflammatory responseGO:0069549.4BCL6, IL10, CXCR4
20response to cytokineGO:0340979.3BCL2, IL4
21positive regulation of B cell proliferationGO:0308909.2BCL2, BCL6, IL4
22chemotaxisGO:0069359.0IL4, CXCL12, CXCR5
23response to drugGO:0424938.9ABCC1, IL4, IL10, BCL2
24G-protein coupled receptor signaling pathwayGO:0071868.8CXCR5, CXCL12, CXCR4
25immune responseGO:0069558.4IL4, CXCL12, CXCR5

Molecular functions related to Intraocular Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1folic acid transporter activityGO:0085179.8SLC19A1, FOLR1
2folic acid bindingGO:0055429.5SLC19A1, FOLR1
3growth factor activityGO:0080839.3IL10, IL4, CXCL12
4C-X-C chemokine receptor activityGO:0164949.3CXCR4, CXCR5

Products for genes affiliated with Intraocular Lymphoma

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  • Antibodies
  • Proteins
  • Lysates

Sources for Intraocular Lymphoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet