PIOL
MCID: INT054
MIFTS: 50

Intraocular Lymphoma (PIOL) malady

Eye, Blood, Cancer, Immune categories

Summaries for Intraocular Lymphoma

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Intraocular lymphoma is a rare malignant form of eye cancer. Intraocular lymphoma may affect the eye... more...

MalaCards: Intraocular Lymphoma, also known as primary intraocular lymphoma, is related to central nervous system lymphoma and central nervous system lymphoma, primary. An important gene associated with Intraocular Lymphoma is IL10 (interleukin 10), and among its related pathways are TGF-Beta Pathway and IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds cyclosporin a and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, brain and retina, and related mouse phenotypes are reproductive system and muscle.

Aliases & Classifications for Intraocular Lymphoma

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 31LifeMap Discovery™, 61UMLS, 49Orphanet, 40NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Eye, Blood, Immune


Characteristics (Orphanet epidemiological data):

49
primary intraocular lymphoma:
Inheritance: Sporadic; Age of onset: Adulthood; Age of death: Elderly


Aliases & Descriptions:

intraocular lymphoma 8 10 45 31 61
primary intraocular lymphoma 8 49
primary intraocular non-hodgkin's lymphoma 49
piol 49


External Ids:

Disease Ontology8 DOID:775
NCIt40 C9184

Related Diseases for Intraocular Lymphoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Intraocular Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 145)
idRelated DiseaseScoreTop Affiliating Genes
1central nervous system lymphoma30.6BCL6
2central nervous system lymphoma, primary30.4CXCR5, BCL6
3uveitis30.4IL4, IL10, CXCR5
4acquired immunodeficiency syndrome30.0IL6, CXCL12
5systemic lupus erythematosus30.0IL6, IL4, IL10, CXCR5
6retina lymphoma10.4
7orbit lymphoma10.2
8cytomegalovirus retinitis10.2
9hyperopia10.0
10colon lymphoma10.0
11choroiditis10.0
12testicular lymphoma10.0
13cerebral lymphoma10.0
14breast lymphoma10.0
15temporal arteritis10.0
16retinal vasculitis10.0
17vasculitis10.0
18multifocal choroiditis10.0
19lymphomatous meningitis10.0
20encephalitis10.0CXCR4
21human immunodeficiency virus infectious disease10.0CXCR4
22malaria10.0IL10
23gastric lymphoma10.0BCL6
24down syndrome10.0SLC19A1
25angioimmunoblastic t-cell lymphoma10.0BCL6
26neutropenia10.0CXCL12
27hepatitis10.0CXCL12
28anaplastic large cell lymphoma10.0BCL6
29oral cancer10.0CXCL12
30kaposi's sarcoma10.0IL6
31rhabdomyosarcoma10.0ABCC1
32peritonitis10.0IL6
33diabetes mellitus10.0IL6
34hyperhomocysteinemia10.0SLC19A1
35cholera10.0CXCR4
36synovitis10.0IL6
37periodontal disease10.0IL6
38endometriosis10.0IL6
39chorioamnionitis10.0IL6
40proliferative diabetic retinopathy10.0CXCL12
41skin disease10.0IL6
42meningitis10.0IL6
43wilms tumor10.0ABCC1
44ischemia10.0CXCL12
45pulmonary disease, chronic obstructive10.0IL6
46graves' disease10.0IL4
47rhinitis10.0IL4
48pulmonary fibrosis10.0CXCL12, CXCR4
49aids dementia complex10.0CXCL12, CXCR4
50myocardial infarction10.0CXCL12, CXCR4

Graphical network of the top 20 diseases related to Intraocular Lymphoma:



Diseases related to intraocular lymphoma

Clinical Features for Intraocular Lymphoma

Drugs & Therapeutics for Intraocular Lymphoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Intraocular Lymphoma

Drug clinical trials:

Search ClinicalTrials for Intraocular Lymphoma

Search NIH Clinical Center for Intraocular Lymphoma

Search CenterWatch for Intraocular Lymphoma

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Intraocular Lymphoma cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Intraocular Lymphoma:
Hematopoietic stem cells for treatment of hematologic malignancies
Embryonic/Adult Cultured Cells Related to Intraocular Lymphoma:
Bone marrow-derived hematopoietic stem cells

Genetic Tests for Intraocular Lymphoma

Anatomical Context for Intraocular Lymphoma

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Intraocular Lymphoma:

33
Bone marrow, Brain, Retina, Colon, Breast, Skin, T cells, B lymphoblasts, B cells, Hypothalamus

Animal Models for Intraocular Lymphoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Intraocular Lymphoma

Sources:
51PubMed
See all sources

Articles related to Intraocular Lymphoma:

(show top 50)    (show all 189)
idTitleAuthorsYear
1
Survival Outcomes of Primary Intraocular Lymphoma: A Single-institution Experience. (24390272)
2014
2
Fundus autofluorescence patterns in primary intraocular lymphoma. (23958842)
2014
3
Intraocular lymphoma: a clinical perspective. (23196650)
2013
4
Preclinical study of Ublituximab, a Glycoengineered anti-human CD20 antibody, in murine models of primary cerebral and intraocular B-cell lymphomas. (23611989)
2013
5
Unilateral retinopathy secondary to occult primary intraocular lymphoma. (24081663)
2013
6
Intravitreal injection of anti-VEGF and diagnosis of primary intraocular central nervous system lymphoma. (23306179)
2013
7
Birdshot retinochoroidopathy masquerading as intraocular lymphoma. (22594959)
2012
8
Enucleation of painful blind eye for refractory intraocular lymphoma after dose-limiting chemotherapy and radiotherapy. (22450776)
2012
9
Intraocular T-cell lymphoma due to mycosis fungoides and response to intravitreal methotrexate. (21770799)
2011
10
Subretinal lymphomatous infiltration in primary intraocular lymphoma revealed by optical coherence tomography. (21509532)
2011
11
Th17 cells are involved in the local control of tumor progression in primary intraocular lymphoma. (21949734)
2011
12
Investigation of kinetics of methotrexate for therapeutic treatment of intraocular lymphoma. (20961217)
2010
13
Intraocular lymphoma diagnosed by fine-needle aspiration biopsy. (19604155)
2010
14
The future of primary intraocular lymphoma (retinal lymphoma). (20001255)
2009
15
Intraocular lymphoma: more questions than answers. (19294566)
2009
16
A case of primary intraocular lymphoma treated by intravitreal methotrexate. (19794951)
2009
17
Positron emission tomography/computed tomography after immunocytochemical and clonal diagnosis of intraocular lymphoma with vitrectomy cell blocks. (19907112)
2009
18
Primary intraocular lymphoma: another great masquerader. (18609476)
2008
19
Cytomegalovirus retinitis mimicking intraocular lymphoma. (19668455)
2008
20
Intensive chemotherapy followed by hematopoietic stem-cell rescue for refractory and recurrent primary CNS and intraocular lymphoma: SociActAc FranAsaise de Greffe de MoA18413641)
2008
21
Protocol for the use of polymerase chain reaction in the detection of intraocular large B-cell lymphoma in ocular samples. (17251344)
2007
22
Ocular masquerade syndrome due to intraocular lymphoma--two forms of retinal pigment epithelium involvement: case reports. (17768564)
2007
23
Somatically mutated immunoglobulin IGHV@ genes without intraclonal heterogeneity indicate a postgerminal centre origin of primary intraocular diffuse large B-cell lymphomas. (17760806)
2007
24
An Asian patient with intraocular lymphoma treated by intravitreal methotrexate. (17013703)
2006
25
Detection of the bcl-2 t(14;18) translocation and proto-oncogene expression in primary intraocular lymphoma. (16799010)
2006
26
Treatment of primary intraocular lymphoma with radiation therapy: a multi-institutional survey in Japan. (17064991)
2006
27
Primary intraocular T-cell-rich large B-cell lymphoma. (16048400)
2005
28
Expression of immunoglobulin transcription factors in primary intraocular lymphoma and primary central nervous system lymphoma. (16249468)
2005
29
Management of primary intraocular lymphoma. (15610690)
2005
30
Pharmacokinetics and efficacy of ifosfamide or trofosfamide in patients with intraocular lymphoma. (16219622)
2005
31
Molecular analysis of immunoglobulin genes in primary intraocular lymphoma. (16186327)
2005
32
Bilaterally identical monoclonality in a case of primary intraocular lymphoma. (15289150)
2004
33
Intravitreal methotrexate injections for intraocular involvement in primary central nervous system lymphoma. (14740803)
2003
34
Intrathecal chemotherapy for recurrent central nervous system intraocular lymphoma. (12799254)
2003
35
Fluorescein angiographic findings in primary intraocular lymphoma. (11884876)
2002
36
Interleukin-10 and intraocular-central nervous system lymphoma. (11237883)
2001
37
Improving the diagnostic yield of vitrectomy for intraocular lymphoma. (10721983)
2000
38
Primary intraocular lymphoma with a low interleukin 10 to interleukin 6 ratio and heterogeneous IgH gene arrangement. (10815178)
2000
39
Primary Intraocular Lymphoma With a Low Interleukin 10 to Interleukin 6 Ratio and Heterogeneous IgH Gene Arrangement. (10815177)
2000
40
Elevated vitreous interleukin-10 level is not diagnostic of intraocular-central nervous system lymphoma. (10599659)
1999
41
Detection of molecular changes in primary intraocular lymphoma by microdissection and polymerase chain reaction. (9646037)
1998
42
ECT in a patient receiving prophylactic CNS irradiation for an intraocular lymphoma. (8701020)
1996
43
Chorioretinal biopsy in the diagnosis of intraocular lymphoma: a case report. (7894759)
1994
44
Intraocular lymphoma developing in a patient with Vogt-Koyanagi-Harada syndrome. (8063475)
1993-1994
45
Intraocular lymphoma: clinical presentations, differential diagnosis and treatment. (2631302)
1989
46
Solitary intraocular lymphoma as an initial presentation of widespread disease. (2647068)
1989
47
Chemotherapy in the management of intraocular lymphoma. (2702565)
1989
48
Intraocular lymphoma. Cytologic diagnosis and the role of immunologic markers. (3264435)
1988
49
Intraocular lymphoma: immunological and cytological analysis. (3067746)
1988
50
Primary intraocular lymphoma (ocular reticulum cell sarcoma) diagnosis and management. (3050698)
1988

Genetic Variations for Intraocular Lymphoma

Expression for genes affiliated with Intraocular Lymphoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Intraocular Lymphoma

Search GEO for disease gene expression data for Intraocular Lymphoma.

Pathways for genes affiliated with Intraocular Lymphoma

Sources:
52QIAGEN, 53R&D Systems, 50PharmGKB, 30KEGG, 12EMD Millipore, 38NCBI BioSystems Database, 54Reactome, 4Cell Signaling Technology
See all sources

Pathways related to Intraocular Lymphoma according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2CXCR4
210.0IL4
3
Hide members
9.7ABCC1, FOLR1
49.7SLC19A1, ABCC1
5
Hide members
9.3CXCR4, CXCL12, BCL2
6
Development Dopamine D2 receptor transactivation of EGFR
Hide members
9.3BCL2, CXCL12, CXCR4
79.2IL10, IL4, BCL2
89.2BCL6, IL4, IL10
99.1IL10, IL6, IL4
10
Hide members
9.1IL6, IL10, IL4
119.1IL10, IL6, IL4
129.1IL6, IL10, BCL2
13
Development PDGF signaling via STATs and NF-kB
Hide members
9.1IL6, IL10, BCL2
14
Hide members
9.0IL6, CXCR5
159.0CXCR4, CXCL12, CXCR5
168.9BCL6, IL4, IL10, CXCL12
17
Hide members
8.5IL10, CXCR4, CXCL12, IL6, IL4
18
Hide members
8.0BCL2, IL6, IL4, IL10, CXCL12, CXCR4
19
Hide members
8.0CXCR4, CXCL12, IL10, IL4, IL6, BCL2
20
Hide members
7.1CXCR4, BCL2, IL6, IL4, IL10, CXCL12

Compounds for genes affiliated with Intraocular Lymphoma

Sources:
45Novoseek, 29IUPHAR, 60Tocris Bioscience, 11DrugBank, 50PharmGKB, 2BitterDB, 24HMDB
See all sources

Compounds related to Intraocular Lymphoma according to GeneCards/GeneDecks:

(show top 50)    (show all 97)
idCompoundScoreTop Affiliating Genes
1cyclosporin a45 29 6012.6CXCR4
2cycloheximide4510.5CXCL12
3gm-csf45 2911.5IL10
4anaphylatoxin4510.2CXCR4, IL4
5estrogen4510.2BCL6
6cyclam4510.1CXCL12, CXCR4
7monomethyl fumarate4510.1IL4, IL10
8bicyclam4510.0CXCL12, CXCR4
9mdms459.9IL10, CXCL12, CXCR4
10n-hydroxysuccinimide459.9FOLR1, SLC19A1
11lamivudine45 1110.9ABCC1, IL4
12plerixafor29 45 1111.8CXCL12, CXCR4
13tomudex459.8SLC19A1, FOLR1, ABCC1
14mcp 1459.7IL6, IL10, CXCR4
15montelukast45 50 29 1112.7IL10, IL4, ABCC1
16lipoteichoic acid459.6CXCR4, IL6, IL10
17zidovudine45 1110.5CXCR4, ABCC1, CXCL12, IL10
18probenecid45 29 60 50 1113.5C19orf48, FOLR1, ABCC1, SLC19A1
19mip 1alpha459.5IL6, IL4, IL10
20tarc459.5CXCR4, IL10, IL4, CXCL12
21quinine45 29 2 1112.5IL4, IL10, CXCL12, CXCR4
22groalpha459.5IL6, CXCL12, IL10
23il-12459.5IL4, IL10, IL6
24polymyxin b459.5IL10, IL4, IL6
25okt3459.4IL6, IL4, IL10
265-aza-2deoxycytidine459.4SLC19A1, FOLR1, CXCR4, CXCL12
27polyinosinic-polycytidylic acid459.4IL10, IL4, IL6
28ccl345 2910.3CXCR4, CXCL12, IL10, IL6
29paclitaxel45 50 1111.3CXCR4, FOLR1, BCL2, ABCC1
30dexamethasone45 50 29 1112.3CXCL12, BCL2, IL6
31cyclophosphamide45 50 1111.2BCL6, CXCL12, BCL2, CXCR4
32il 10459.2IL10, IL4, IL6
33pentoxifylline45 1110.1IL6, IL10, IL4
34herbimycin a45 6010.1CXCR4, IL6, IL4, CXCL12
35ibuprofen45 29 50 11 2413.1IL10, BCL2, ABCC1, IL6
36thymidylate459.0SLC19A1, ABCC1, IL10, BCL2, FOLR1
37vincristine45 50 1111.0ABCC1, BCL2, SLC19A1, BCL6
38methotrexate45 50 1110.9FOLR1, IL10, IL6, SLC19A1, ABCC1
39infliximab45 50 1110.8IL4, IL10, IL6
405fluorouracil458.7ABCC1, CXCL12, SLC19A1, BCL2
41cisplatin45 50 60 1111.7SLC19A1, C19orf48, BCL2, FOLR1, CXCR4, ABCC1
42rituximab45 50 1110.6IL6, IL10, CXCL12, BCL2, BCL6
43calcitriol45 60 11 2411.5IL4, IL6, IL10, CXCR5
44doxorubicin45 50 1110.5C19orf48, FOLR1, ABCC1, SLC19A1, BCL6, BCL2
45sb 20358045 609.4IL6, BCL2, CXCR4, IL4, IL10, CXCL12
46ly294002458.4BCL2, IL6, IL4, CXCR4, CXCL12, IL10
47rantes458.4CXCL12, CXCR4, CXCR5, IL6, IL4
48vegf458.3CXCR4, IL6, CXCL12, IL4, IL10, BCL2
49actinomycin d458.2IL6, BCL2, ABCC1, CXCR4, CXCL12, IL4
50imatinib45 50 1110.1ABCC1, CXCR4, CXCL12, IL10, IL4, BCL6

GO Terms for genes affiliated with Intraocular Lymphoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Intraocular Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.7IL6, IL4, CXCL12, CXCR4

Biological processes related to Intraocular Lymphoma according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1ameboidal cell migrationGO:00166710.1CXCL12, CXCR4
2regulation of isotype switchingGO:04519110.1IL10, IL4
3folic acid transportGO:01588410.0FOLR1, SLC19A1
4folic acid metabolic processGO:04665510.0FOLR1, SLC19A1
5positive regulation of MHC class II biosynthetic processGO:04534810.0IL10, IL4
6germ cell migrationGO:00835410.0CXCL12, CXCR4
7negative regulation of nitric oxide biosynthetic processGO:0450199.9IL10, IL4
8B cell proliferationGO:0421009.8IL10, BCL2
9T cell proliferationGO:0420989.7CXCR4, CXCL12
10type 2 immune responseGO:0420929.6BCL6, IL4, IL10
11B cell differentiationGO:0301839.5IL10, IL4, BCL6
12motor neuron axon guidanceGO:0080459.5CXCL12, CXCR4
13defense response to protozoanGO:0428329.4IL4, IL6
14positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.4IL6, IL10, IL4
15response to glucocorticoid stimulusGO:0513849.3IL6, BCL2, IL10
16positive regulation of B cell proliferationGO:0308909.3IL4, BCL6, BCL2
17chemotaxisGO:0069358.9IL4, CXCL12, CXCR5
18negative regulation of apoptotic processGO:0430668.6BCL2, IL6, IL4, IL10
19response to drugGO:0424938.5ABCC1, BCL2, IL10, IL4, IL6

Molecular functions related to Intraocular Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1folic acid bindingGO:0055429.5FOLR1, SLC19A1
2C-X-C chemokine receptor activityGO:0164949.3CXCR5, CXCR4
3cytokine activityGO:0051259.1IL10, IL4, IL6
4growth factor activityGO:0080838.8IL6, CXCL12, IL10, IL4

Products for genes affiliated with Intraocular Lymphoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Intraocular Lymphoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet