MCID: INT054
MIFTS: 57

Intraocular Lymphoma malady

Eye diseases, Blood diseases, Cancer diseases, Rare diseases, Immune diseases categories

Summaries for Intraocular Lymphoma

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Wikipedia:65 Intraocular lymphoma is a rare malignant form of eye cancer. Intraocular lymphoma may affect the eye... more...

MalaCards based summary: Intraocular Lymphoma, also known as primary intraocular lymphoma, is related to uveitis and systemic lupus erythematosus. An important gene associated with Intraocular Lymphoma is IL10 (interleukin 10), and among its related pathways are Syndecan-4-mediated signaling events and Signaling by Slit. The compounds cyclam and bicyclam have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and b cells, and related mouse phenotypes are craniofacial and liver/biliary system.

Aliases & Classifications for Intraocular Lymphoma

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Intraocular Lymphoma, Aliases & Descriptions:

Name: Intraocular Lymphoma 32 10 12 45 62
Primary Intraocular Lymphoma 10 49 62
 
Primary Intraocular Non-Hodgkin's Lymphoma 49
Piol 49


Classifications:



Characteristics (Orphanet epidemiological data):

49
primary intraocular lymphoma:
Inheritance: Not applicable; Age of onset: Adult; Age of death: elderly


External Ids:

Disease Ontology10 DOID:775
NCIt40 C9184
Orphanet49 279904

Related Diseases for Intraocular Lymphoma

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Diseases related to Intraocular Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 93)
idRelated DiseaseScoreTop Affiliating Genes
1uveitis30.4IL10, IL4, CXCR5
2systemic lupus erythematosus30.1CXCR5, IL4, IL10
3retinitis10.5
4central nervous system lymphoma10.4
5chorioretinitis10.2
6panuveitis10.2
7cytomegalovirus retinitis10.2
8hyperopia10.1
9testicular lymphoma10.1
10acquired immunodeficiency syndrome10.1
11orbit lymphoma10.1
12retinal vasculitis10.1
13choroiditis10.1
14cerebritis10.1
15cerebral lymphoma10.1
16breast lymphoma10.1
17temporal arteritis10.1
18endophthalmitis10.1
19hypopyon10.1
20lupus erythematosus10.1
21meningitis10.1
22sarcoma10.1
23vasculitis10.1
24multifocal choroiditis10.1
25blindness10.1
26central nervous system lymphoma, primary10.0BCL6, CXCR5
27precursor b-cell acute lymphoblastic leukemia10.0CXCR5, CXCR4
28folic acid deficiency anemia10.0FOLR1, SLC19A1
29whim syndrome10.0CXCL12, CXCR4
30aids dementia complex10.0CXCL12, CXCR4
31plasmacytoma10.0CXCR5, BCL6
32mantle cell lymphoma10.0BCL6, BCL2
33lymphosarcoma10.0BCL6, BCL2
34periodontitis10.0IL10, CXCR4
35burkitt lymphoma10.0BCL2, BCL6
36selective iga deficiency disease10.0IL10, IL4
37lepromatous leprosy10.0IL4, IL10
38visceral leishmaniasis10.0IL10, IL4
39cutaneous leishmaniasis10.0IL4, IL10
40reticulosarcoma10.0BCL6, BCL2
41neural tube defects10.0FOLR1, SLC19A1
42malt lymphoma10.0CXCR5, BCL6, BCL2
43acute graft versus host disease10.0IL10, IL4
44follicular lymphoma10.0CXCR5, BCL6, BCL2
45common variable immunodeficiency10.0IL10, IL4
46diabetes mellitus, insulin-dependent10.0IL10, IL4
47leishmaniasis10.0IL4, IL10
48b-cell lymphomas10.0BCL2, BCL6, CXCR5
49schistosomiasis10.0IL10, IL4
50vascular disease10.0CXCL12, IL10, BCL2

Graphical network of the top 20 diseases related to Intraocular Lymphoma:



Diseases related to intraocular lymphoma

Symptoms for Intraocular Lymphoma

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Drugs & Therapeutics for Intraocular Lymphoma

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Drug clinical trials:

Search ClinicalTrials for Intraocular Lymphoma

Search NIH Clinical Center for Intraocular Lymphoma

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Intraocular Lymphoma cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Intraocular Lymphoma:
Hematopoietic stem cells for treatment of hematologic malignancies
Embryonic/Adult Cultured Cells Related to Intraocular Lymphoma:
Bone marrow-derived hematopoietic stem cells

Genetic Tests for Intraocular Lymphoma

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Anatomical Context for Intraocular Lymphoma

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MalaCards organs/tissues related to Intraocular Lymphoma:

33
Brain, Eye, B cells, Retina, Bone, T cells, Colon, Breast, Hypothalamus

Animal Models for Intraocular Lymphoma or affiliated genes

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Publications for Intraocular Lymphoma

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Articles related to Intraocular Lymphoma:

(show top 50)    (show all 176)
idTitleAuthorsYear
1
Intraocular lymphoma: a clinical perspective. (23196650)
2013
2
Current concepts in diagnosing and managing primary vitreoretinal (intraocular) lymphoma. (23449111)
2013
3
Primary intraocular lymphoma: treatment outcomes with ocular radiation therapy alone. (23822539)
2013
4
Secondary orbital and intraocular lymphoma treated with immunochemotherapy. (25391121)
2013
5
Unilateral retinopathy secondary to occult primary intraocular lymphoma. (24081663)
2013
6
Birdshot retinochoroidopathy masquerading as intraocular lymphoma. (22594959)
2012
7
Retinal optical coherence tomography manifestations of intraocular lymphoma. (22477623)
2012
8
Spontaneous regression of intraocular lymphoma. (22551603)
2012
9
Clinical features and diagnostic significance of the intraocular fluid of 217 patients with intraocular lymphoma. (22661396)
2012
10
Enucleation of painful blind eye for refractory intraocular lymphoma after dose-limiting chemotherapy and radiotherapy. (22450776)
2012
11
Subretinal lymphomatous infiltration in primary intraocular lymphoma revealed by optical coherence tomography. (21509532)
2011
12
Concurrent administration of intravenous systemic and intravitreal methotrexate for intraocular lymphoma with central nervous system involvement. (20464643)
2010
13
Fundus autofluorescence patterns in eyes with primary intraocular lymphoma. (19834356)
2010
14
25-Gauge transconjunctival sutureless vitrectomy for the diagnosis of intraocular lymphoma. (20447965)
2010
15
Diagnosis of intraocular lymphoma by polymerase chain reaction analysis and cytokine profiling of the vitreous fluid. (19484437)
2009
16
Primary intraocular lymphoma. (19653715)
2009
17
Primary intraocular lymphoma: diagnosis and differential diagnosis. (19585354)
2009
18
Ocular tuberculoma mimicking intraocular lymphoma. (19412865)
2009
19
Ifosfamide or trofosfamide in patients with intraocular lymphoma. (19099202)
2009
20
Successful use of semi-nested PCR for the diagnosis of primary intraocular lymphoma. (18608860)
2008
21
Intraocular lymphoma following a primary testicular lymphoma in remission for 10 years. (17985076)
2008
22
IL-10 measurement in aqueous humor for screening patients with suspicion of primary intraocular lymphoma. (17591896)
2007
23
Primary intraocular lymphoma mimicking multifocal choroiditis and panuveitis. (17304253)
2007
24
Ocular masquerade syndrome due to intraocular lymphoma--two forms of retinal pigment epithelium involvement: case reports. (17768564)
2007
25
An Asian patient with intraocular lymphoma treated by intravitreal methotrexate. (17013703)
2006
26
Detection of the bcl-2 t(14;18) translocation and proto-oncogene expression in primary intraocular lymphoma. (16799010)
2006
27
Anterior chamber paracentesis cytology (cytospin technique) for the diagnosis of intraocular lymphoma. (16488933)
2006
28
Intraocular lymphoma 2000-2005: results of a retrospective multicentre trial. (16228920)
2006
29
Primary intraocular lymphoma: current and future perspectives. (17064977)
2006
30
Murine model of primary intraocular lymphoma. (15671263)
2005
31
Molecular pathology of primary intraocular lymphoma. (14971583)
2003
32
Evaluation of vitrectomy specimens and chorioretinal biopsies in the diagnosis of primary intraocular lymphoma in patients with Masquerade syndrome. (14605902)
2003
33
Pseudo-hypopyon as the presenting feature in B-cell and T-cell intraocular lymphoma. (12648051)
2003
34
Variations in the presentation of primary intraocular lymphoma: case reports and a review. (11425352)
2001
35
Primary intraocular lymphoma with a low interleukin 10 to interleukin 6 ratio and heterogeneous IgH gene rearrangement. (10496399)
1999
36
Use of the polymerase chain reaction to detect B- and T-cell gene rearrangements in vitreous specimens from patients with intraocular lymphoma. (10369586)
1999
37
Using interleukin 10 to interleukin 6 ratio to distinguish primary intraocular lymphoma and uveitis. (10476821)
1999
38
Intravitreal chemotherapy for the treatment of recurrent intraocular lymphoma. (10434868)
1999
39
Intraocular Lymphoma. (10761081)
1998
40
Diagnosis of intraocular lymphoma by polymerase chain reaction. (9248839)
1997
41
ECT in a patient receiving prophylactic CNS irradiation for an intraocular lymphoma. (8701020)
1996
42
Interleukin-10 in the vitreous of patients with primary intraocular lymphoma. (7485372)
1995
43
Intraocular lymphoma presenting as retinal vasculitis. (7801221)
1994
44
Intraocular lymphoma invades the optic nerve and orbit. (8427488)
1993
45
Intraocular lymphoma. Clinical and histopathologic diagnosis. (8371930)
1993
46
Presumed intraocular lymphoma in a 60-year-old man with AIDS. (1490092)
1992
47
Intraocular lymphoma: clinical presentations, differential diagnosis and treatment. (2631302)
1989
48
Solitary intraocular lymphoma as an initial presentation of widespread disease. (2647068)
1989
49
Chemotherapy in the management of intraocular lymphoma. (2702565)
1989
50
Treatment of intraocular lymphoma with high-dose Ara-C. (2418934)
1986

Variations for Intraocular Lymphoma

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Cosmic variations for Intraocular Lymphoma:

8
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Conf
143448TNFAIP3haematopoietic and lymphoid tissue,central nervous system,lymphoid neoplasm,primary central nervous system lymphoma1

Expression for genes affiliated with Intraocular Lymphoma

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Search GEO for disease gene expression data for Intraocular Lymphoma.

Pathways for genes affiliated with Intraocular Lymphoma

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Pathways related to Intraocular Lymphoma according to GeneCards/GeneDecks:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CXCR4, CXCL12
29.8CXCR4, CXCL12
3
Show member pathways
S1P2 pathway38
S1P4 pathway38
S1P5 pathway38
S1P1 pathway38
Sphingosine 1-phosphate (S1P) pathway38
9.7CXCR4, ABCC1
49.7IL4, IL10
59.7IL10, IL4
69.6SLC19A1, ABCC1
7
Show member pathways
9.6BCL2, IL10
89.4BCL2, ABCC1
9
Show member pathways
IL2 signaling events mediated by STAT538
9.3BCL2, IL4
109.3BCL2, BCL6
11
Show member pathways
9.3SLC19A1, FOLR1, ABCC1
129.1IL4, IL10, BCL6
13
Show member pathways
Apoptosis and survival BAD phosphorylation60
Development Alpha 2 adrenergic receptor activation of ERK60
Chemotaxis CXCR4 signaling pathway60
9.1BCL2, CXCR4, CXCL12
149.0IL4, IL10, BCL2
15
Show member pathways
9.0IL4, IL10, BCL2
16
Show member pathways
9.0CXCL12, CXCR4, IL4, IL10
17
Show member pathways
8.9CXCR4, CXCL12, CXCR5
18
Show member pathways
8.9CXCR5, CXCL12, CXCR4
198.7BCL6, IL10, IL4, CXCL12
20
Show member pathways
8.3CXCL12, CXCR4, IL4, IL10, BCL2
21
Show member pathways
8.3CXCL12, CXCR4, IL4, IL10, BCL2
22
Show member pathways
8.3CXCL12, CXCR4, IL4, IL10, BCL2
23
Show member pathways
8.3CXCL12, CXCR4, IL4, IL10, BCL2
24
Show member pathways
7.5CXCR5, CXCL12, CXCR4, IL4, IL10, BCL2

Compounds for genes affiliated with Intraocular Lymphoma

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Compounds related to Intraocular Lymphoma according to GeneCards/GeneDecks:

(show top 50)    (show all 105)
idCompoundScoreTop Affiliating Genes
1cyclam4510.1CXCR4, CXCL12
2bicyclam4510.1CXCL12, CXCR4
3plerixafor45 30 1312.1CXCL12, CXCR4
4n-hydroxysuccinimide4510.1FOLR1, SLC19A1
5monomethyl fumarate4510.0IL10, IL4
6lometrexol4510.0FOLR1, SLC19A1
7sdf 1459.9CXCL12, CXCR4
8betaseron459.9IL4, IL10
9mdms459.9IL10, CXCR4, CXCL12
101843u89459.9ABCC1, SLC19A1
11acidophilus459.8IL4, IL10
12ccl345 3010.8IL10, CXCR4, CXCL12
13trimetrexate45 1310.8SLC19A1, FOLR1
14tomudex459.7SLC19A1, FOLR1, ABCC1
15anaphylatoxin459.6CXCL12, CXCR4, IL4
16montelukast45 51 30 1312.6IL10, IL4, ABCC1
17lamivudine45 51 1311.6ABCC1, IL4, IL10
18interferon gamma459.6IL10, IL4
19zidovudine45 51 1311.4IL10, CXCR4, CXCL12, ABCC1
205-aza-2deoxycytidine459.4CXCL12, CXCR4, FOLR1, SLC19A1
21probenecid30 45 61 51 1313.4ABCC1, C19orf48, FOLR1, SLC19A1
22ibuprofen45 30 51 26 1313.4BCL2, IL10, ABCC1
23tarc459.4IL10, IL4, CXCR4, CXCL12
24quinine45 30 3 51 1313.4CXCL12, CXCR4, IL4, IL10
25methotrexate51 45 1311.4ABCC1, FOLR1, IL10, SLC19A1
26daunorubicin45 51 1311.4ABCC1, C19orf48, BCL2
27chloroquine45 3 51 30 1313.3IL10, IL4, ABCC1
28carboplatin45 51 1311.1ABCC1, CXCR4, BCL2, SLC19A1
29rapamycin459.1CXCL12, CXCR4, IL10, BCL2
30rituximab45 51 1311.1CXCL12, IL10, BCL6, BCL2
31cyclosporin a45 30 6111.0ABCC1, C19orf48, CXCR4, IL4, IL10
325fluorouracil459.0SLC19A1, BCL2, CXCL12, ABCC1
33vincristine45 51 1310.9ABCC1, BCL6, BCL2, SLC19A1
34thymidylate458.8ABCC1, FOLR1, IL10, BCL2, SLC19A1
35gemcitabine45 51 1310.8ABCC1, IL10, BCL2
36paclitaxel45 51 1310.8ABCC1, CXCR4, FOLR1, BCL2, SLC19A1
37sb 20358045 619.8CXCL12, CXCR4, IL4, IL10, BCL2
38ly294002458.7CXCL12, CXCR4, IL4, IL10, BCL2
39dexamethasone45 51 30 1311.7CXCL12, CXCR4, IL4, IL10, BCL2
40vegf458.6CXCL12, CXCR4, IL4, IL10, BCL2
41paraffin458.6IL4, IL10, BCL6, BCL2
42actinomycin d458.6ABCC1, CXCL12, CXCR4, IL4, BCL2
43rantes458.6CXCR5, CXCL12, CXCR4, IL4, IL10
44cisplatin45 51 61 1311.5ABCC1, C19orf48, CXCR4, FOLR1, BCL2, SLC19A1
45estrogen458.3BCL2, BCL6, CXCR4, CXCL12, C19orf48
46doxorubicin45 51 1310.3ABCC1, C19orf48, FOLR1, BCL6, BCL2, SLC19A1
47cyclophosphamide45 51 1310.3CXCL12, CXCR4, IL4, IL10, BCL6, BCL2
48cycloheximide458.2CXCL12, CXCR4, IL4, IL10, BCL6, BCL2
49serine458.1CXCL12, CXCR4, FOLR1, BCL6, BCL2, SLC19A1
50imatinib45 51 139.8BCL2, ABCC1, CXCL12, CXCR4, IL4, IL10

GO Terms for genes affiliated with Intraocular Lymphoma

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Cellular components related to Intraocular Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098978.9IL4, CXCR4, CXCL12
2membraneGO:00160208.7SLC19A1, BCL2, FOLR1, ABCC1

Biological processes related to Intraocular Lymphoma according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1ameboidal cell migrationGO:000166710.1CXCR4, CXCL12
2folic acid transportGO:001588410.1FOLR1, SLC19A1
3folic acid metabolic processGO:004665510.1SLC19A1, FOLR1
4germ cell migrationGO:000835410.0CXCL12, CXCR4
5T cell proliferationGO:004209810.0CXCR4, CXCL12
6regulation of isotype switchingGO:004519110.0IL4, IL10
7motor neuron axon guidanceGO:000804510.0CXCR4, CXCL12
8positive regulation of MHC class II biosynthetic processGO:004534810.0IL10, IL4
9chemokine-mediated signaling pathwayGO:007009810.0CXCR4, CXCL12
10negative regulation of nitric oxide biosynthetic processGO:004501910.0IL4, IL10
11germ cell developmentGO:00072819.9CXCL12, CXCR4
12patterning of blood vesselsGO:00015699.9CXCR4, CXCL12
13B cell proliferationGO:00421009.7BCL2, IL10
14regulation of calcium ion transportGO:00519249.7CXCL12, BCL2
15response to radiationGO:00093149.7BCL2, CXCL12
16type 2 immune responseGO:00420929.5BCL6, IL10, IL4
17B cell differentiationGO:00301839.5BCL6, IL10, IL4
18extrinsic apoptotic signaling pathway in absence of ligandGO:00971929.4BCL2, IL4
19inflammatory responseGO:00069549.4BCL6, IL10, CXCR4
20response to cytokineGO:00340979.3BCL2, IL4
21positive regulation of B cell proliferationGO:00308909.2BCL2, BCL6, IL4
22chemotaxisGO:00069359.0IL4, CXCL12, CXCR5
23response to drugGO:00424938.9ABCC1, IL4, IL10, BCL2
24G-protein coupled receptor signaling pathwayGO:00071868.8CXCR5, CXCL12, CXCR4
25immune responseGO:00069558.4IL4, CXCL12, CXCR5

Molecular functions related to Intraocular Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1folic acid transporter activityGO:00085179.8SLC19A1, FOLR1
2folic acid bindingGO:00055429.5SLC19A1, FOLR1
3growth factor activityGO:00080839.3IL10, IL4, CXCL12
4C-X-C chemokine receptor activityGO:00164949.3CXCR4, CXCR5

Products for genes affiliated with Intraocular Lymphoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Intraocular Lymphoma

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet