PIOL
MCID: INT054
MIFTS: 58

Intraocular Lymphoma (PIOL) malady

Eye diseases, Blood diseases, Cancer diseases, Immune diseases categories

Summaries for Intraocular Lymphoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Intraocular lymphoma is a rare malignant form of eye cancer. Intraocular lymphoma may affect the eye... more...

MalaCards: Intraocular Lymphoma, also known as primary intraocular lymphoma, is related to central nervous system lymphoma and uveitis. An important gene associated with Intraocular Lymphoma is IL10 (interleukin 10), and among its related pathways are TGF-Beta Pathway and IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds cyclosporin a and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and b cells, and related mouse phenotypes are reproductive system and muscle.

Aliases & Classifications for Intraocular Lymphoma

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8Disease Ontology, 10DISEASES, 44Novoseek, 48Orphanet, 30LifeMap Discovery™, 60UMLS, 39NCIt, 57SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Eye diseases, Blood diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

48
primary intraocular lymphoma:
Inheritance: Sporadic; Age of onset: Adulthood; Age of death: Elderly


Aliases & Descriptions:

intraocular lymphoma 8 10 44 30 60
primary intraocular lymphoma 8 48
primary intraocular non-hodgkin's lymphoma 48
piol 48


External Ids:

Disease Ontology8 DOID:775
NCIt39 C9184
SNOMED-CT via Orphanet57 420788006

Related Diseases for Intraocular Lymphoma

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Intraocular Lymphoma:



Diseases related to intraocular lymphoma

Clinical Features for Intraocular Lymphoma

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Drugs & Therapeutics for Intraocular Lymphoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Intraocular Lymphoma

Drug clinical trials:

Search ClinicalTrials for Intraocular Lymphoma

Search NIH Clinical Center for Intraocular Lymphoma

Search CenterWatch for Intraocular Lymphoma

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Intraocular Lymphoma cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Intraocular Lymphoma:
Hematopoietic stem cells for treatment of hematologic malignancies
Embryonic/Adult Cultured Cells Related to Intraocular Lymphoma:
Bone marrow-derived hematopoietic stem cells

Genetic Tests for Intraocular Lymphoma

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Anatomical Context for Intraocular Lymphoma

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32MalaCards
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MalaCards organs/tissues related to Intraocular Lymphoma:

32
Brain, Eye, B cells, Retina, T cells, Bone, Colon, Skin, Breast, Hypothalamus

Animal Models for Intraocular Lymphoma or affiliated genes

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36MGI
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Publications for Intraocular Lymphoma

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50PubMed
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Articles related to Intraocular Lymphoma:

(show top 50)    (show all 189)
idTitleAuthorsYear
1
Preliminary results of radiotherapy for primary intraocular non-Hodgkin lymphoma. (23343177)
2013
2
A possible coincidence of cytomegalovirus retinitis and intraocular lymphoma in a patient with systemic non-Hodgkin's lymphoma. (23295015)
2013
3
Cytokine profile in human eyes: contribution of a new cytokine combination for differential diagnosis between intraocular lymphoma or uveitis. (23405064)
2013
4
Spontaneous regression of intraocular lymphoma. (22551603)
2012
5
Retrospective cytological study of intraocular lymphoma using vitreous and intraocular perfusion fluid. (22707324)
2012
6
Intraocular T-cell lymphoma due to mycosis fungoides and response to intravitreal methotrexate. (21770799)
2011
7
Primary intraocular lymphoma: a review. (21626069)
2011
8
Fundus autofluorescence patterns in eyes with primary intraocular lymphoma. (19834356)
2010
9
Analyses of ERG in a patient with intraocular lymphoma. (20463797)
2010
10
Intraocular lymphoma diagnosed by fine-needle aspiration biopsy. (19604155)
2010
11
Diagnostic vitrectomy (25-gauge) in a case with intraocular lymphoma masquerading as bilateral granulomatous panuveitis. (20099241)
2010
12
The future of primary intraocular lymphoma (retinal lymphoma). (20001255)
2009
13
Epidemiology and clinical features of intraocular lymphoma. (19412864)
2009
14
Controversies in intraocular lymphoma. (19294565)
2009
15
Intraocular lymphoma: more questions than answers. (19294566)
2009
16
Cytokine and molecular analyses of intraocular lymphoma. (19585355)
2009
17
Rituximab for intraocular lymphoma. (19202422)
2009
18
Treatment of primary intraocular lymphoma with intravitreal methotrexate. (18661266)
2008
19
Cytopathological analysis of vitreous in intraocular lymphoma. (17767143)
2008
20
Ocular masquerade syndrome due to intraocular lymphoma--two forms of retinal pigment epithelium involvement: case reports. (17768564)
2007
21
Somatically mutated immunoglobulin IGHV@ genes without intraclonal heterogeneity indicate a postgerminal centre origin of primary intraocular diffuse large B-cell lymphomas. (17760806)
2007
22
Intraocular lymphoma metastasis from larynx. (17294396)
2007
23
Primary intraocular lymphoma: improving the diagnostic procedure. (17324466)
2007
24
Detection of the bcl-2 t(14;18) translocation and proto-oncogene expression in primary intraocular lymphoma. (16799010)
2006
25
Anterior chamber paracentesis cytology (cytospin technique) for the diagnosis of intraocular lymphoma. (16488933)
2006
26
Intraocular lymphoma 2000-2005: results of a retrospective multicentre trial. (16228920)
2006
27
Treatment of primary intraocular lymphoma with radiation therapy: a multi-institutional survey in Japan. (17064991)
2006
28
Primary intraocular T-cell-rich large B-cell lymphoma. (16048400)
2005
29
Primary intraocular lymphoma arising during methotrexate treatment of temporal arteritis. (16391621)
2005
30
Management of primary intraocular lymphoma. (15610690)
2005
31
Pathology and genetics of primary central nervous system and intraocular lymphoma. (16083831)
2005
32
Molecular analysis of immunoglobulin genes in primary intraocular lymphoma. (16186327)
2005
33
Intraocular lymphoma as a masquerade syndrome complicating cerebral lymphoma of the corpus callosum. (15558282)
2005
34
Isolated, bilateral intraocular lymphoma in a 15-year-old girl. (15805919)
2005
35
Treatment of primary intraocular lymphoma with oral trofosfamide: report of two cases and review of the literature. (15349786)
2004
36
Primary intraocular lymphoma: clinical, cytologic, and flow cytometric analysis. (15350334)
2004
37
Intravitreal methotrexate injections for intraocular involvement in primary central nervous system lymphoma. (14740803)
2003
38
Molecular pathology of primary intraocular lymphoma. (14971583)
2003
39
Pseudo-hypopyon as the presenting feature in B-cell and T-cell intraocular lymphoma. (12648051)
2003
40
Intrathecal chemotherapy for recurrent central nervous system intraocular lymphoma. (12799254)
2003
41
Primary intraocular lymphoma: clinical features, diagnosis, and treatment. (12837151)
2003
42
Expression of chemokine receptors, CXCR4 and CXCR5, and chemokines, BLC and SDF-1, in the eyes of patients with primary intraocular lymphoma. (12578791)
2003
43
Variations in the presentation of primary intraocular lymphoma: case reports and a review. (11425352)
2001
44
Using interleukin 10 to interleukin 6 ratio to distinguish primary intraocular lymphoma and uveitis. (10476821)
1999
45
Utility of microdissection and polymerase chain reaction for the detection of immunoglobulin gene rearrangement and translocation in primary intraocular lymphoma. (9754175)
1998
46
Diagnosis of intraocular lymphoma by polymerase chain reaction. (9248839)
1997
47
Primary intraocular lymphoma mimicking late postoperative endophthalmitis. (8751342)
1995
48
Intraocular lymphoma presenting as retinal vasculitis. (7801221)
1994
49
Primary intraocular lymphoma with lymphomatous meningitis. (2304056)
1990
50
Chemotherapy in the management of intraocular lymphoma. (2702565)
1989

Genetic Variations for Intraocular Lymphoma

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Expression for genes affiliated with Intraocular Lymphoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Intraocular Lymphoma

Search GEO for disease gene expression data for Intraocular Lymphoma.

Pathways for genes affiliated with Intraocular Lymphoma

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Sources:
51QIAGEN, 52R&D Systems, 49PharmGKB, 29KEGG, 12EMD Millipore, 37NCBI BioSystems Database, 53Reactome, 4Cell Signaling Technology
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Pathways related to Intraocular Lymphoma according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2CXCR4
210.0IL4
3
Hide members
9.7ABCC1, FOLR1
49.7ABCC1, SLC19A1
5
Hide members
9.3CXCR4, CXCL12, BCL2
6
Development Dopamine D2 receptor transactivation of EGFR
Hide members
9.3BCL2, CXCL12, CXCR4
79.2BCL2, IL4, IL10
89.2BCL6, IL4, IL10
99.1IL10, IL4, IL6
10
Hide members
9.1IL6, IL4, IL10
119.1IL6, IL4, IL10
129.1BCL2, IL6, IL10
13
Development PDGF signaling via STATs and NF-kB
Hide members
9.1IL10, IL6, BCL2
14
Hide members
9.0CXCR5, IL6
159.0CXCR4, CXCR5, CXCL12
168.9BCL6, IL4, IL10, CXCL12
17
Hide members
8.5CXCR4, CXCL12, IL10, IL4, IL6
18
Hide members
8.0BCL2, IL6, IL4, IL10, CXCL12, CXCR4
19
Hide members
8.0CXCR4, CXCL12, IL10, IL4, IL6, BCL2
20
Hide members
7.1BCL2, IL6, IL4, IL10, CXCL12, CXCR5

Compounds for genes affiliated with Intraocular Lymphoma

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Sources:
44Novoseek, 28IUPHAR, 59Tocris Bioscience, 11DrugBank, 49PharmGKB, 2BitterDB, 24HMDB
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Compounds related to Intraocular Lymphoma according to GeneCards/GeneDecks:

(show top 50)    (show all 97)
idCompoundScoreTop Affiliating Genes
1cyclosporin a44 28 5912.6CXCR4
2cycloheximide4410.5CXCL12
3gm-csf44 2811.5IL10
4anaphylatoxin4410.2CXCR4, IL4
5estrogen4410.2BCL6
6cyclam4410.1CXCR4, CXCL12
7monomethyl fumarate4410.1IL10, IL4
8bicyclam449.9CXCR4, CXCL12
9mdms449.9IL10, CXCL12, CXCR4
10lamivudine44 1110.9ABCC1, IL4
11n-hydroxysuccinimide449.9FOLR1, SLC19A1
12plerixafor28 44 1111.8CXCR4, CXCL12
13tomudex449.8FOLR1, ABCC1, SLC19A1
14mcp 1449.7CXCR4, IL10, IL6
15montelukast44 49 28 1112.7IL10, IL4, ABCC1
16lipoteichoic acid449.6CXCR4, IL10, IL6
17zidovudine44 1110.5CXCR4, CXCL12, IL10, ABCC1
18probenecid44 28 59 49 1113.5C19orf48, FOLR1, ABCC1, SLC19A1
19mip 1alpha449.5IL6, IL4, IL10
20groalpha449.5CXCL12, IL10, IL6
21tarc449.5CXCR4, CXCL12, IL10, IL4
22quinine44 28 2 1112.5IL4, IL10, CXCL12, CXCR4
23il-12449.5IL10, IL4, IL6
24polymyxin b449.5IL6, IL4, IL10
25okt3449.4IL10, IL4, IL6
265-aza-2deoxycytidine449.4SLC19A1, CXCL12, CXCR4, FOLR1
27polyinosinic-polycytidylic acid449.4IL10, IL4, IL6
28ccl344 2810.3CXCR4, CXCL12, IL10, IL6
29paclitaxel44 49 1111.3FOLR1, CXCR4, ABCC1, BCL2
30dexamethasone44 49 28 1112.3BCL2, IL6, CXCL12
31il 10449.3IL10, IL4, IL6
32cyclophosphamide44 49 1111.2BCL2, BCL6, CXCL12, CXCR4
33pentoxifylline44 1110.1IL6, IL4, IL10
34herbimycin a44 5910.1CXCR4, CXCL12, IL4, IL6
35ibuprofen44 28 49 11 2413.1BCL2, ABCC1, IL6, IL10
36thymidylate449.0BCL2, SLC19A1, ABCC1, IL10, FOLR1
37vincristine44 49 1111.0ABCC1, SLC19A1, BCL6, BCL2
38methotrexate44 49 1110.9FOLR1, IL10, IL6, ABCC1, SLC19A1
39infliximab44 49 1110.8IL6, IL4, IL10
405fluorouracil448.7CXCL12, ABCC1, SLC19A1, BCL2
41cisplatin44 49 59 1111.7C19orf48, FOLR1, CXCR4, ABCC1, SLC19A1, BCL2
42rituximab44 49 1110.6CXCL12, IL10, IL6, BCL6, BCL2
43calcitriol44 59 11 2411.5CXCR5, IL10, IL4, IL6
44doxorubicin44 49 1110.5C19orf48, FOLR1, ABCC1, SLC19A1, BCL6, BCL2
45sb 20358044 599.4CXCR4, CXCL12, IL10, IL4, IL6, BCL2
46ly294002448.4CXCR4, CXCL12, IL10, IL4, IL6, BCL2
47rantes448.4CXCR4, CXCR5, CXCL12, IL4, IL6
48vegf448.3CXCR4, CXCL12, IL10, IL4, IL6, BCL2
49actinomycin d448.2CXCR4, CXCL12, IL4, IL6, ABCC1, BCL2
50imatinib44 49 1110.1BCL2, CXCR4, CXCL12, IL10, IL4, ABCC1

GO Terms for genes affiliated with Intraocular Lymphoma

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16Gene Ontology
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Cellular components related to Intraocular Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.7IL6, IL4, CXCL12, CXCR4

Biological processes related to Intraocular Lymphoma according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1ameboidal cell migrationGO:00166710.1CXCR4, CXCL12
2regulation of isotype switchingGO:04519110.1IL10, IL4
3folic acid transportGO:01588410.0SLC19A1, FOLR1
4folic acid metabolic processGO:04665510.0SLC19A1, FOLR1
5positive regulation of MHC class II biosynthetic processGO:04534810.0IL10, IL4
6germ cell migrationGO:00835410.0CXCR4, CXCL12
7negative regulation of nitric oxide biosynthetic processGO:0450199.9IL4, IL10
8B cell proliferationGO:0421009.8BCL2, IL10
9T cell proliferationGO:0420989.7CXCL12, CXCR4
10type 2 immune responseGO:0420929.6BCL6, IL4, IL10
11B cell differentiationGO:0301839.5BCL6, IL4, IL10
12motor neuron axon guidanceGO:0080459.5CXCR4, CXCL12
13defense response to protozoanGO:0428329.4IL6, IL4
14positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.4IL6, IL4, IL10
15response to glucocorticoid stimulusGO:0513849.3IL10, IL6, BCL2
16positive regulation of B cell proliferationGO:0308909.3BCL2, BCL6, IL4
17chemotaxisGO:0069358.9CXCR5, CXCL12, IL4
18negative regulation of apoptotic processGO:0430668.6BCL2, IL6, IL4, IL10
19response to drugGO:0424938.5IL10, IL4, IL6, ABCC1, BCL2

Molecular functions related to Intraocular Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1folic acid bindingGO:0055429.5SLC19A1, FOLR1
2C-X-C chemokine receptor activityGO:0164949.3CXCR4, CXCR5
3cytokine activityGO:0051259.1IL6, IL4, IL10
4growth factor activityGO:0080838.8IL6, IL4, IL10, CXCL12

Products for genes affiliated with Intraocular Lymphoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Intraocular Lymphoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet