PIOL
MCID: INT054
MIFTS: 58

Intraocular Lymphoma (PIOL) malady

Eye diseases, Blood diseases, Cancer diseases, Immune diseases categories

Summaries for Intraocular Lymphoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Intraocular lymphoma is a rare malignant form of eye cancer. Intraocular lymphoma may affect the eye... more...

MalaCards: Intraocular Lymphoma, also known as primary intraocular lymphoma, is related to central nervous system lymphoma and uveitis. An important gene associated with Intraocular Lymphoma is IL10 (interleukin 10), and among its related pathways are TGF-Beta Pathway and IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds cyclosporin a and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and b cells, and related mouse phenotypes are reproductive system and muscle.

Aliases & Classifications for Intraocular Lymphoma

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8Disease Ontology, 10DISEASES, 44Novoseek, 30LifeMap Discovery™, 60UMLS, 48Orphanet, 39NCIt, 57SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Eye diseases, Blood diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

48
primary intraocular lymphoma:
Inheritance: Sporadic; Age of onset: Adulthood; Age of death: Elderly


Aliases & Descriptions:

intraocular lymphoma 8 10 44 30 60
primary intraocular lymphoma 8 48
primary intraocular non-hodgkin's lymphoma 48
piol 48


External Ids:

Disease Ontology8 DOID:775
NCIt39 C9184
SNOMED-CT via Orphanet57 420788006

Related Diseases for Intraocular Lymphoma

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Intraocular Lymphoma:



Diseases related to intraocular lymphoma

Clinical Features for Intraocular Lymphoma

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Drugs & Therapeutics for Intraocular Lymphoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Intraocular Lymphoma

Drug clinical trials:

Search ClinicalTrials for Intraocular Lymphoma

Search NIH Clinical Center for Intraocular Lymphoma

Search CenterWatch for Intraocular Lymphoma

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Intraocular Lymphoma cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Intraocular Lymphoma:
Hematopoietic stem cells for treatment of hematologic malignancies
Embryonic/Adult Cultured Cells Related to Intraocular Lymphoma:
Bone marrow-derived hematopoietic stem cells

Genetic Tests for Intraocular Lymphoma

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Anatomical Context for Intraocular Lymphoma

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32MalaCards
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MalaCards organs/tissues related to Intraocular Lymphoma:

32
Brain, Eye, B cells, Retina, T cells, Bone, Skin, Breast, Colon, Hypothalamus

Animal Models for Intraocular Lymphoma or affiliated genes

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36MGI
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Publications for Intraocular Lymphoma

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50PubMed
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Articles related to Intraocular Lymphoma:

(show top 50)    (show all 189)
idTitleAuthorsYear
1
Survival Outcomes of Primary Intraocular Lymphoma: A Single-institution Experience. (24390272)
2014
2
Intraocular lymphoma: a clinical perspective. (23196650)
2013
3
Unilateral retinopathy secondary to occult primary intraocular lymphoma. (24081663)
2013
4
Intraocular lymphoma after cardiac transplantation: magnetic resonance imaging findings. (23323042)
2013
5
Longitudinal spectral domain optical coherence tomography changes in eyes with intraocular lymphoma. (24011267)
2013
6
Birdshot retinochoroidopathy masquerading as intraocular lymphoma. (22594959)
2012
7
Clinical features and diagnostic significance of the intraocular fluid of 217 patients with intraocular lymphoma. (22661396)
2012
8
Repeated IL-10 measurement in aqueous humor and OCT imaging are valuable tools to monitor intraocular lymphoma treated with intravitreal injections of methotrexate. (21755434)
2012
9
Secondary intraocular uveal involvement by primary paranasal sinus lymphoma. (22581320)
2012
10
Treatment of primary intraocular lymphoma with rituximab, high dose methotrexate, procarbazine, and vincristine chemotherapy, reduced whole-brain radiotherapy, and local ocular therapy. (22085111)
2012
11
Subretinal lymphomatous infiltration in primary intraocular lymphoma revealed by optical coherence tomography. (21509532)
2011
12
Concurrent administration of intravenous systemic and intravitreal methotrexate for intraocular lymphoma with central nervous system involvement. (20464643)
2010
13
Intraocular lymphoma and central nervous system lymphoma involving the hypothalamus: staging and evaluation of response to therapy with F-18 FDG PET/CT. (21206231)
2010
14
Primary intraocular lymphoma: diagnosis and differential diagnosis. (19585354)
2009
15
Ocular tuberculoma mimicking intraocular lymphoma. (19412865)
2009
16
Ifosfamide or trofosfamide in patients with intraocular lymphoma. (19099202)
2009
17
Intraocular lymphoma: diagnostic approach and immunophenotypic findings in vitrectomy specimens. (19653716)
2009
18
A case of primary intraocular lymphoma treated by intravitreal methotrexate. (19794951)
2009
19
B cell monoclonality of intraocular lymphoma and breast lymphoma. (18227215)
2008
20
Intravitreal methotrexate resistance in a patient with primary intraocular lymphoma. (18379939)
2008
21
IL-10 measurement in aqueous humor for screening patients with suspicion of primary intraocular lymphoma. (17591896)
2007
22
Primary intraocular lymphoma mimicking multifocal choroiditis and panuveitis. (17304253)
2007
23
Protocol for the use of polymerase chain reaction in the detection of intraocular large B-cell lymphoma in ocular samples. (17251344)
2007
24
Treatment outcomes for primary intraocular lymphoma: implications for external beam radiotherapy. (16732210)
2007
25
Diagnosis and management of primary intraocular lymphoma: an update. (19668478)
2007
26
Primary intraocular lymphoma: an International Primary Central Nervous System Lymphoma Collaborative Group Report. (17804469)
2007
27
Intraocular lymphoma. (16770155)
2006
28
Eradication of tumor colonization and invasion by a B cell-specific immunotoxin in a murine model for human primary intraocular lymphoma. (17079483)
2006
29
Expression of immunoglobulin transcription factors in primary intraocular lymphoma and primary central nervous system lymphoma. (16249468)
2005
30
Diagnosis and management of primary intraocular lymphoma. (16083834)
2005
31
The elusive nature of primary intraocular lymphoma. (15756131)
2005
32
Diagnostic value of interleukin-10 and interleukin-6 in the vitreous of intraocular malignant lymphoma patients]. (15242071)
2004
33
Diagnosis of intraocular lymphoma. (15209459)
2004
34
Primary intraocular lymphoma: a review of the clinical, histopathological and molecular biological features. (15565454)
2004
35
Cytologic diagnosis of intraocular lymphoma in vitreous aspirates. (15296338)
2004
36
Intraocular lymphoma: a series of 14 patients with clinicopathological features and treatment outcomes. (12802353)
2003
37
Intraocular lymphoma. (12441846)
2002
38
Interleukin-10 and intraocular-central nervous system lymphoma. (11237883)
2001
39
Improving the diagnostic yield of vitrectomy for intraocular lymphoma. (10721983)
2000
40
Primary Intraocular Lymphoma With a Low Interleukin 10 to Interleukin 6 Ratio and Heterogeneous IgH Gene Arrangement. (10815177)
2000
41
Primary intraocular lymphoma with a low interleukin 10 to interleukin 6 ratio and heterogeneous IgH gene rearrangement. (10496399)
1999
42
Elevated vitreous interleukin-10 level is not diagnostic of intraocular-central nervous system lymphoma. (10599659)
1999
43
Intraocular Lymphoma. (10761081)
1998
44
Chorioretinal biopsy in the diagnosis of intraocular lymphoma: a case report. (7894759)
1994
45
Intraocular lymphoma--a case report. (8485311)
1993
46
Presumed intraocular lymphoma in a 60-year-old man with AIDS. (1490092)
1992
47
Intraocular lymphoma. Immunopathologic analysis of vitreous biopsy specimens. (1417546)
1992
48
Intraocular lymphoma: clinical presentations, differential diagnosis and treatment. (2631302)
1989
49
Intraocular lymphoma: immunological and cytological analysis. (3067746)
1988
50
Treatment of intraocular lymphoma with high-dose Ara-C. (2418934)
1986

Genetic Variations for Intraocular Lymphoma

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Expression for genes affiliated with Intraocular Lymphoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Intraocular Lymphoma

Search GEO for disease gene expression data for Intraocular Lymphoma.

Pathways for genes affiliated with Intraocular Lymphoma

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Sources:
51QIAGEN, 52R&D Systems, 49PharmGKB, 29KEGG, 12EMD Millipore, 37NCBI BioSystems Database, 53Reactome, 4Cell Signaling Technology
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Pathways related to Intraocular Lymphoma according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2CXCR4
210.0IL4
3
Hide members
9.7ABCC1, FOLR1
49.7ABCC1, SLC19A1
5
Hide members
9.3CXCR4, CXCL12, BCL2
6
Development Dopamine D2 receptor transactivation of EGFR
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9.3BCL2, CXCL12, CXCR4
79.2BCL2, IL4, IL10
89.2BCL6, IL4, IL10
99.1IL10, IL4, IL6
10
Hide members
9.1IL6, IL4, IL10
119.1IL6, IL4, IL10
129.1BCL2, IL6, IL10
13
Development PDGF signaling via STATs and NF-kB
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9.1IL10, IL6, BCL2
14
Hide members
9.0CXCR5, IL6
159.0CXCR4, CXCR5, CXCL12
168.9BCL6, IL4, IL10, CXCL12
17
Hide members
8.5CXCR4, CXCL12, IL10, IL4, IL6
18
Hide members
8.0BCL2, IL6, IL4, IL10, CXCL12, CXCR4
19
Hide members
8.0CXCR4, CXCL12, IL10, IL4, IL6, BCL2
20
Hide members
7.1BCL2, IL6, IL4, IL10, CXCL12, CXCR5

Compounds for genes affiliated with Intraocular Lymphoma

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Sources:
44Novoseek, 28IUPHAR, 59Tocris Bioscience, 11DrugBank, 49PharmGKB, 2BitterDB, 24HMDB
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Compounds related to Intraocular Lymphoma according to GeneCards/GeneDecks:

(show top 50)    (show all 97)
idCompoundScoreTop Affiliating Genes
1cyclosporin a44 28 5912.6CXCR4
2cycloheximide4410.5CXCL12
3gm-csf44 2811.5IL10
4anaphylatoxin4410.2CXCR4, IL4
5estrogen4410.2BCL6
6cyclam4410.1CXCL12, CXCR4
7monomethyl fumarate4410.1IL4, IL10
8bicyclam4410.0CXCL12, CXCR4
9mdms449.9IL10, CXCL12, CXCR4
10n-hydroxysuccinimide449.9FOLR1, SLC19A1
11lamivudine44 1110.9ABCC1, IL4
12plerixafor28 44 1111.8CXCL12, CXCR4
13tomudex449.8SLC19A1, FOLR1, ABCC1
14mcp 1449.7IL6, IL10, CXCR4
15montelukast44 49 28 1112.7IL10, IL4, ABCC1
16lipoteichoic acid449.6CXCR4, IL6, IL10
17zidovudine44 1110.5CXCR4, ABCC1, CXCL12, IL10
18probenecid44 28 59 49 1113.5C19orf48, FOLR1, ABCC1, SLC19A1
19mip 1alpha449.5IL6, IL4, IL10
20tarc449.5CXCR4, IL10, IL4, CXCL12
21quinine44 28 2 1112.5IL4, IL10, CXCL12, CXCR4
22groalpha449.5IL6, CXCL12, IL10
23il-12449.5IL4, IL10, IL6
24polymyxin b449.5IL10, IL4, IL6
25okt3449.4IL6, IL4, IL10
265-aza-2deoxycytidine449.4SLC19A1, FOLR1, CXCR4, CXCL12
27polyinosinic-polycytidylic acid449.4IL10, IL4, IL6
28ccl344 2810.3CXCR4, CXCL12, IL10, IL6
29paclitaxel44 49 1111.3CXCR4, FOLR1, BCL2, ABCC1
30dexamethasone44 49 28 1112.3CXCL12, BCL2, IL6
31cyclophosphamide44 49 1111.2BCL6, CXCL12, BCL2, CXCR4
32il 10449.2IL10, IL4, IL6
33pentoxifylline44 1110.1IL6, IL10, IL4
34herbimycin a44 5910.1CXCR4, IL6, IL4, CXCL12
35ibuprofen44 28 49 11 2413.1IL10, BCL2, ABCC1, IL6
36thymidylate449.0SLC19A1, ABCC1, IL10, BCL2, FOLR1
37vincristine44 49 1111.0ABCC1, BCL2, SLC19A1, BCL6
38methotrexate44 49 1110.9FOLR1, IL10, IL6, SLC19A1, ABCC1
39infliximab44 49 1110.8IL4, IL10, IL6
405fluorouracil448.7ABCC1, CXCL12, SLC19A1, BCL2
41cisplatin44 49 59 1111.7SLC19A1, C19orf48, BCL2, FOLR1, CXCR4, ABCC1
42rituximab44 49 1110.6IL6, IL10, CXCL12, BCL2, BCL6
43calcitriol44 59 11 2411.5IL4, IL6, IL10, CXCR5
44doxorubicin44 49 1110.5C19orf48, FOLR1, ABCC1, SLC19A1, BCL6, BCL2
45sb 20358044 599.4IL6, BCL2, CXCR4, IL4, IL10, CXCL12
46ly294002448.4BCL2, IL6, IL4, CXCR4, CXCL12, IL10
47rantes448.4CXCL12, CXCR4, CXCR5, IL6, IL4
48vegf448.3CXCR4, IL6, CXCL12, IL4, IL10, BCL2
49actinomycin d448.2IL6, BCL2, ABCC1, CXCR4, CXCL12, IL4
50imatinib44 49 1110.1ABCC1, CXCR4, CXCL12, IL10, IL4, BCL6

GO Terms for genes affiliated with Intraocular Lymphoma

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16Gene Ontology
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Cellular components related to Intraocular Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.7IL6, IL4, CXCL12, CXCR4

Biological processes related to Intraocular Lymphoma according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1ameboidal cell migrationGO:00166710.1CXCR4, CXCL12
2regulation of isotype switchingGO:04519110.1IL10, IL4
3folic acid transportGO:01588410.0SLC19A1, FOLR1
4folic acid metabolic processGO:04665510.0SLC19A1, FOLR1
5positive regulation of MHC class II biosynthetic processGO:04534810.0IL10, IL4
6germ cell migrationGO:00835410.0CXCR4, CXCL12
7negative regulation of nitric oxide biosynthetic processGO:0450199.9IL4, IL10
8B cell proliferationGO:0421009.8BCL2, IL10
9T cell proliferationGO:0420989.7CXCL12, CXCR4
10type 2 immune responseGO:0420929.6BCL6, IL4, IL10
11B cell differentiationGO:0301839.5BCL6, IL4, IL10
12motor neuron axon guidanceGO:0080459.5CXCR4, CXCL12
13defense response to protozoanGO:0428329.4IL6, IL4
14positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.4IL6, IL4, IL10
15response to glucocorticoid stimulusGO:0513849.3IL10, IL6, BCL2
16positive regulation of B cell proliferationGO:0308909.3BCL2, BCL6, IL4
17chemotaxisGO:0069358.9CXCR5, CXCL12, IL4
18negative regulation of apoptotic processGO:0430668.6BCL2, IL6, IL4, IL10
19response to drugGO:0424938.5IL10, IL4, IL6, ABCC1, BCL2

Molecular functions related to Intraocular Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1folic acid bindingGO:0055429.5SLC19A1, FOLR1
2C-X-C chemokine receptor activityGO:0164949.3CXCR4, CXCR5
3cytokine activityGO:0051259.1IL6, IL4, IL10
4growth factor activityGO:0080838.8IL6, IL4, IL10, CXCL12

Products for genes affiliated with Intraocular Lymphoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Intraocular Lymphoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet