Intrauterine Infections malady

Wikipedia: TORCH complex (also known as STORCH, TORCHES or the TORCH infections) is a medical acronym for a set of...⁴⁴ more...

MalaCards: Intrauterine Infections, also known as intrauterine infection, is related to hepatitis and hepatitis b. An important gene associated with Intrauterine Infections is INHBA (inhibin, beta A), and among its related pathways are Bacterial infections in CF airways and RAR-Gamma-RXR-Alpha Degradation. The compounds ivig and budesonide have been mentioned in the context of this disorder. Affiliated tissues include lung, placenta and cervix, and related mouse phenotypes are respiratory system and hematopoietic system.

intrauterine infections 30 intrauterine infection 43

Diseases related to intrauterine infections by text searches and GeneDecks gene sharing:

(show top 50)    (show all 731)

id	Related Disease	Score	Top Affiliating Genes
1	hepatitis	30.6	CCL20, HLA-DRB1, LTF
2	hepatitis b	29.7	IL10, IFNG, HLA-DRB1
3	torch syndrome	29.2	TERC, DKC1
4	cervicitis	20.6	MMP8, INHBA, IL10, IL1A, IL1B, IL1R1
5	dyskeratosis congenita	13.5	TERC, DKC1
6	dyskeratosis congenita autosomal dominant	13.5	TERC, DKC1
7	aggressive periodontitis	13.3	MMP8, IL1A, LTF
8	aspiration pneumonia	13.3	CRP, ELANE
9	chronic ulcer of skin	13.3	MMP8, EGF, ELANE
10	reactive arthritis	13.2	MMP8, CRP, LTF
11	cinca syndrome	13.2	IL1B, IL1R1
12	pustulosis of palm and sole	13.2	TNF, ELANE
13	perinatal necrotizing enterocolitis	13.2	LTF, EGF
14	aneurysm disease	13.2	MMP8, CRP, ELANE
15	rheumatoid arthritis	13.1	IL1R1, HLA-DRB1, CRP
16	immunodysregulation	13.1	IL10, HLA-DRB1
17	punctate inner choroidopathy	13.1	IL10, TNF
18	slow-channel congenital myasthenic syndrome	13.1	IL8, CRP
19	familial cold autoinflammatory syndrome	13.1	IL1B, IL1R1
20	central nervous system leukemia	13.1	IL1B, TNF
21	chronic infantile neurological cutaneous articular syndrome	13.1	IL1B, IL1R1, CRP
22	epidural abscess	13.1	TNF, CRP
23	selective iga deficiency disease	13.1	IL10, IL4
24	keratoconjunctivitis sicca	13.1	IL1A, IL4, LTF
25	cough variant asthma	13.1	IL10, IL4
26	euthyroid sick syndrome	13.1	IL1B, IL6
27	cryptosporidiosis	13.1	IL1A, IL4, LTF
28	cystic fibrosis lung disease	13.0	IL8, ELANE
29	panuveitis	13.0	IL10, TNF
30	sepsis	13.0	IL10, TNF
31	specific granule deficiency	13.0	IL8, LTF
32	hyper-igd syndrome	13.0	TNF, CRP
33	eosinophilic meningitis	13.0	IL10, IL4
34	staphylococcal toxic shock syndrome	13.0	IL1B, TNF
35	rapidly progressive glomerulonephritis	13.0	TNF, CRP, ELANE
36	stenotrophomonas maltophilia	13.0	IL10, IL8
37	endotoxin hyporesponsiveness	13.0	IL1B, TNF
38	adult-onset still's disease	13.0	IL1R1, IL6, CRP
39	radiculopathy	13.0	IL1A, IL1R1, IL6
40	viral meningitis	12.9	IL6, CRP
41	ulceration of vulva	12.9	MMP8, LTF, EGF
42	rheumatoid vasculitis	12.9	HLA-DRB1, TNF, LTF
43	ankylosing spondylitis	12.9	IL1R1, TNF, CRP
44	vulvovaginitis	12.9	IL10, IL4, LTF
45	charcot-marie-tooth neuropathy type 2a	12.9	IL6, TNF
46	cellulitis	12.9	IL1R1, TNF, CRP
47	vulvar vestibulitis syndrome	12.9	IL1B, IL1R1, TNF
48	bronchitis	12.9	IL8, LTF, ELANE
49	malignant histiocytosis	12.9	IL1A, IL1B, IL1R1, CRP
50	chronic venous leg ulcers	12.9	HLA-DRB1, TNF, ELANE

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to intrauterine infections:

²²

MGI Mouse Phenotypes related to intrauterine infections:

²⁵ (show all 16)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.5	DKC1
2	hematopoietic system phenotype	MP:0005397	10.3	DKC1, TERC
3	endocrine/exocrine gland phenotype	MP:0005379	9.9	IFNG
4	skeleton phenotype	MP:0005390	9.7	IL1R1, IL6, INHBA, TERC
5	liver/biliary system phenotype	MP:0005370	9.1	IL6, IL1R1, IFNG
6	digestive/alimentary phenotype	MP:0005381	9.0	EGF, TERC, IFNG, INHBA
7	homeostasis/metabolism phenotype	MP:0005376	9.0	DKC1, ELANE, LTF, CRP, INHBA, IL1A
8	growth/size phenotype	MP:0005378	8.8	INHBA, IL6, EGF, DKC1, TERC
9	integument phenotype	MP:0010771	8.3	INHBA, IL4, IFNG, TERC, EGF, DKC1
10	immune system phenotype	MP:0005387	7.9	IL6, IFNG, TNF, LTF, ELANE, TERC
11	mortality/aging	MP:0010768	7.8	IL1B, IL6, IFNG, ELANE, DKC1, INHBA
12	muscle phenotype	MP:0005369	7.5	TERC, TNF, IFNG, INHBA, IL10, IL1R1
13	reproductive system phenotype	MP:0005389	7.4	INHBA, IL10, DKC1, TERC, TNF, IFNG
14	vision/eye phenotype	MP:0005391	7.1	TERC, TNF, EGF, IFNG, IL6, IL4
15	tumorigenesis	MP:0002006	6.8	ELANE, IL6, MMP8, DKC1, TERC, TNF
16	cardiovascular system phenotype	MP:0005385	6.6	IL1B, TERC, IL10, TNF, IFNG, IL6

Articles related to intrauterine infections:

(show all 22)

id	Title	Authors	Year	Affiliating Genes
1	Activin A as a marker of intrauterine infection in wo men with preterm prelabour rupture of membranes. (19641514)	Hodges R.... Wallace E.M.	2010	INHBA
2	Procalcitonin, neopterin and C-reactive protein in di agnostics of intrauterine infection and preterm delivery. (20017453)	Greksova K.... Borovsky M.	2009	CRP
3	Association between the frequency of class II HLA antigens and the susceptibility to intrauterine infection of hepatitis B virus. (18463715)	Xu Y.Y.... Li Q.	2008	HLA-DRB1
4	Exodus-1 (CCL20): evidence for the participation of this chemokine in spontaneous labor at term, preterm labor, and intrauterine infection. (18576931)	Hamill N.... Hassan S.S.	2008	CCL20
5	The Alabama preterm birth study: corticosteroids and neonatal outcomes in 23- to 32-week newborns with various markers of intrauterine infection. (17000235)	Goldenberg R.L.... Hauth J.C.	2006	IL6
6	Evaluation levels of cytokines in amniotic fluid of women with intrauterine infection in the early second trimester. (16354974)	Suzuki Y.... Suzumori K.	2006	IL6
7	Relationship between cytokine gene polymorphism and susceptibility to hepatitis B virus intrauterine infection (15941525)	Zhu Q.R.... Fei L.E.	2005	TNF, IL4, IFNG
8	Relationship between cytokines gene polymorphism and susceptibility to hepatitis B virus intrauterine infection. (16232344)	Zhu Q.R.... Dong Z.Q.	2005	TNF, IL4, IFNG
9	Two brothers with findings resembling congenital intrauterine infection-like syndrome (pseudo-TORCH syndrome). (12833411)	Knoblauch H.... Tinschert S.	2003	DKC1, TERC
10	Usefulness of determination of granulocyte elastase plasma level, c-reactive protein and white blood cell count in prediction in intrauterine infection in pregnant women after PROM (14669391)	BaA8kowska E.M.... PawA8owska A.	2003	CRP
11	Maternal serum and amniotic fluid cytokines in patients with preterm premature rupture of membranes with and without intrauterine infection. (12445984)	Shobokshi A.... Shaarawy M.	2002	EGF
12	Human neutrophil collagenase (matrix metalloproteinase 8) in parturition, premature rupture of the membranes, and intrauterine infection. (10920315)	Maymon E.... Yoon B.H.	2000	MMP8
13	Amniotic fluid lactoferrin in intrauterine infection. (10195738)	Otsuki K.... Yanaihara T.	1999	IL6, LTF
14	Cytokine release from placental endothelial cells, a process associated with preterm labour in the absence of intrauterine infection. (10080881)	Steinborn A.... Kaufmann M.	1999	IL6, IL1B
15	Ultrasonographic assessment of the uterine cervix and interleukin-8 concentrations in cervical secretions predict intrauterine infection in patients with preterm labor and intact membranes. (9744050)	Rizzo G.... Romanini C.	1998	IL8
16	Intrauterine infections. I. The role of C-reactive protein, white blood cell count and erythrocyte sedimentation rate in pregnant women in the detection of intrauterine infection after preliminary rupture of membranes (9813940)	Nowak M.... MacioA8ek-Blewniewska G.	1998	CRP
17	Interleukin 8 and granulocyte elastase in the tracheobronchial aspirate of infants without respiratory distress syndrome or intrauterine infection and development of chronic lung disease. (9316287)	Takasaki J.... Ogawa Y.	1997	IL8, ELANE
18	Intrauterine infection and the effects of inflammatory mediators on prostaglandin production by myometrial cells from pregnant women. (8623807)	Pollard J.K.... Mitchell M.D.	1996	EGF
19	A model of intrauterine infection and preterm delivery in mice. (7538729)	Hirsch E.... Hirsh D.	1995	IL1B, IL1A
20	The natural interleukin-1 receptor antagonist in the fetal, maternal, and amniotic fluid compartments: the effect of gestational age, fetal gender, and intrauterine infection. (7943101)	Romero R.... Cotton D.B.	1994	IL1R1
21	Placental interleukin-6 production is enhanced in intrauterine infection but not in labor. (8420357)	Matsuzaki N.... Tanizawa O.	1993	IL6
22	Human placenta constitutively produces interleukin-8 during pregnancy and enhances its production in intrauterine infection. (1391327)	Shimoya K.... Tanizawa O.	1992	IL8

Genes related to intrauterine infections according to GeneCards:

(show all 19)

id	Symbol	Description	Score	GeneCards Section Context
1	INHBA	inhibin, beta A	11.0	Publications
2	DKC1	dyskeratosis congenita 1, dyskerin	11.0	Publications
3	MMP8	matrix metallopeptidase 8 (neutrophil collagenase)	11.0	Publications
4	TERC	telomerase RNA component	11.0	Publications
5	CCL20	chemokine (C-C motif) ligand 20	11.0	Publications
6	IL1R1	interleukin 1 receptor, type I	11.0	Publications
7	IL1A	interleukin 1, alpha	11.0	Publications
8	LTF	lactotransferrin	11.0	Publications
9	ELANE	elastase, neutrophil expressed	11.0	Publications
10	IL8	interleukin 8	11.0	Publications
11	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications
12	IL4	interleukin 4	11.0	Publications
13	CRP	C-reactive protein, pentraxin-related	11.0	Publications
14	EGF	epidermal growth factor	11.0	Publications
15	HLA-DRB1	major histocompatibility complex, class II, DR beta 1	11.0	Publications
16	IL10	interleukin 10	11.0	Publications
17	IL1B	interleukin 1, beta	11.0	Publications
18	IFNG	interferon, gamma	11.0	Publications
19	TNF	tumor necrosis factor	11.0	Publications

Pathways related to intrauterine infections according to GeneDecks:

(show top 50)    (show all 89)

id	Pathway	Score	Top Affiliating Genes
1	Bacterial infections in CF airways41	10.7	IL1R1
2	RAR-Gamma-RXR-Alpha Degradation36	10.6	CCL20
3	Graft-versus-host disease20	10.6	IL1A
4	NFAT Signaling and Lymphocyte Interactions36	10.0	IL1A, CCL20, IL4
5	Molecular Mechanisms of Cancer36	9.6	IL1R1, IL6, EGF, CCL20
6	Regulation of eIF4 and p70S6K36	9.5	EGF, IL6, IL4, IL1A
7	IL-6 Pathway36	9.5	IL10, IL4, IL8, CCL20
8	Akt Signaling36	9.2	IL4, IL10, IL6, TNF
9	PGC1Alpha Pathway36	8.9	IL1A, IL1B, IL1R1, IL4, IL8, CCL20
10	Tec Kinases Signaling36	8.8	CCL20, IL8, IL6, IL4, IL10, EGF
11	Immune response_Bacterial infections in normal airways41	8.7	IFNG, IL1B, IL1R1
12	Immune response IL-1 signaling pathway10	8.6	IL1A, IL8, IL6, IL1R1, IL1B, TNF
13	Immune response_IL-1 signaling pathway41	8.6	IL1A, IL8, TNF, IL6, IL1R1, IL1B
14	Rho Family GTPases36	8.5	IL8, IL4, IL1B, IL1A, IL10, CCL20
15	IL-10 Pathway36	8.5	IL1B, IL6, TNF, IL10, IL1A
16	Pertussis20	8.3	IL10, IL1A, TNF, IL1B, IL8, IL6
17	Hematopoietic cell lineage20	8.1	IL1B, IL1R1, TNF, HLA-DRB1, IL6, IL4
18	Allograft rejection20	8.0	IFNG, TNF, HLA-DRB1, IL4, IL10
19	Immune response MIF in innate immunity response10	8.0	IL1B, IL8, IFNG, TNF, IL6
20	THC Differentiation Pathway36	8.0	IFNG, IL4, TNF, HLA-DRB1, IL10
21	Glucocorticoid Receptor Signaling36	8.0	IL10, IL1B, IL1R1, IL8, IL4, IL6
22	Immune response_MIF in innate immunity response41	8.0	IL1B, IL6, IL8, IFNG, TNF
23	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	7.9	IL1A, IL1B, IL6, IFNG, TNF
24	Transcription Role of VDR in regulation of genes involved in osteoporosis10	7.9	IFNG, IL1A, IL1B, IL6, TNF
25	African trypanosomiasis20	7.9	IL6, TNF, IL10, IL1B, IFNG
26	SOCS Pathway36	7.9	EGF, CCL20, IL8, IL10, IL4, IL6
27	Type I diabetes mellitus20	7.9	IL1A, TNF, HLA-DRB1, IFNG, IL1B
28	MIF Mediated Glucocorticoid Regulation36	7.8	IL4, IL10, IL1B, IL6, IL1A, CCL20
29	MIF Regulation of Innate Immune Cells36	7.8	CCL20, TNF, IL8, IL6, IL4, IL1B
30	all-trans-Retinoic Acid Signaling in Brain36	7.8	IL1B, IL1A, IL10, TNF, IL6, CCL20
31	PEDF Induced Signaling36	7.8	IL1B, TNF, CCL20, IL8, IL6, IL4
32	Malaria20	7.7	TNF, IFNG, IL6, IL1B, IL10, IL8
33	HMGB1 Pathway36	7.7	IL1A, TNF, IFNG, IL1R1, IL1B
34	Endothelin-1 Signaling Pathway36	7.7	IL1A, IL8, IL1B, TNF, CCL20, IL6
35	PAK Pathway36	7.7	IL1A, IL10, IL6, IL8, CCL20, TNF
36	TGF-Beta Pathway36	7.6	CCL20, IL8, IL6, IL1R1, IL1B, IL1A
37	STAT3 Pathway36	7.6	IL1R1, IL4, IL6, IL1B, CCL20, TNF
38	Chagas disease (American trypanosomiasis)20	7.5	IL1B, IL10, TNF, IFNG, IL8, IL6
39	Amoebiasis20	7.5	TNF, IL10, IL1B, IL1R1, IL6, IL8
40	Influenza A20	7.5	TNF, IL1A, IL1B, IL6, IL8, IFNG
41	Rheumatoid arthritis20	7.4	CCL20, IL1B, TNF, HLA-DRB1, IFNG, IL8
42	Leishmaniasis20	7.4	IFNG, IL10, HLA-DRB1, IL1A, IL1B, IL4
43	Tuberculosis20	7.2	IL10, IL1A, IL1B, IL6, IFNG, HLA-DRB1
44	Cytokine Network36	7.2	TNF, IL1B, IL10, IL1A, IL4, IL6
45	ERK Signaling36	7.1	IL1B, IL1A, IL10, IL6, IL8, CCL20
46	MAPK Family Pathway36	7.1	IL4, EGF, IL1A, IL10, IL1B, IL6
47	Antioxidant Action of Vitamin-C36	7.1	IL4, IL1R1, IL1B, IL1A, IL6, IL8
48	p38 Signaling36	7.1	TNF, IL1R1, CCL20, IL1A, EGF, IL8
49	JAK-STAT Pathway36	6.8	IL1B, IL1A, IL1R1, IL4, IL8, CCL20
50	Cytokine-cytokine receptor interaction20	6.1	TNF, IFNG, CCL20, IL8, IL6, IL4

Compounds related to intrauterine infections according to GeneDecks:

(show top 50)    (show all 191)

id	Compound	Score	Top Affiliating Genes
1	ivig32	10.5	CRP
2	budesonide32 42 9 9	13.4	LTF
3	calcitriol32 42 9 18 9	14.1	EGF
4	n acetylcysteine32	9.7	LTF, IL1R1
5	pge232	9.5	EGF, LTF, IL1R1, IL1A, MMP8
6	endotoxin32	9.5	ELANE, LTF, CRP, CCL20, IL1R1
7	okt332	9.0	IL6, TNF, CRP, IL10
8	groalpha32	8.8	IL1B, IL10, TNF, IL1A
9	cdp57132	8.7	IL10, IL6, TNF, CRP
10	vegf32	8.7	LTF, MMP8, CRP, CCL20, IL1R1, IL1B
11	rantes32	8.7	IL4, IL1A, IL6, CCL20, IL1R1, IFNG
12	cyclosporin a32 42	9.7	ELANE, IL8, IL1A, LTF, IL4, IL10
13	sulfasalazine32 9 9	10.6	IL1B, IL1A, IL1R1, TNF, CRP
14	anakinra32 9 9	10.6	TNF, IL6, IL1R1, CRP, IL1B
15	polyinosinic-polycytidylic acid32	8.6	IL10, IFNG, IL8, IL6, IL4
16	gabexate mesilate32	8.5	TNF, ELANE, IL10, CRP, IL6, IL8
17	ulinastatin32	8.4	IL10, ELANE, IL8, TNF, IL6
18	mip 1alpha32	8.2	IL8, IL10, IL6, IL1B, TNF, IL4
19	sb 20358032 42	9.2	IL1R1, IL6, IFNG, TNF, CRP, EGF
20	imiquimod32 42 9 9	11.1	IL10, IFNG, IL8, TNF, IL6, IL1A
21	peptidoglycan32	8.1	TNF, CCL20, IL8, IL6, IL1B, IL10
22	lipoteichoic acid32	8.1	IL1R1, TNF, IL8, IL6, IL1B, IL10
23	leukotriene b432 42 18	10.0	IL6, IL8, IL1R1, IL1B, IL1A, TNF
24	adalimumab32 9 9	10.0	IFNG, CRP, IL1R1, IL10, TNF, IL6
25	tenidap42 32	9.0	IL6, TNF, CRP, LTF, ELANE, IL1R1
26	rolipram32 42	9.0	TNF, IL10, IL4, IL8, IFNG, ELANE
27	taurine chloramine32	8.0	TNF, IL8, IL1B, IL6, IFNG
28	tarc32	7.8	CCL20, IL8, IL4, IL10, IL1A, IFNG
29	fluticasone propionate32 42 9 9	10.8	IL1B, IL4, ELANE, TNF, IFNG, IL8
30	poly(i-c)32	7.7	TNF, IFNG, IL8, IL6, IL4, IL1B
31	gold sodium thiomalate32	7.7	TNF, HLA-DRB1, IFNG, IL8, IL1R1, IL1B
32	pdtc32	7.6	IL6, IL1A, IL1B, TNF, IFNG, IL8
33	simvastatin32 34 42 9 18 9	12.3	IL4, IFNG, IL6, CRP, TNF, IL8
34	15-deoxy-delta-12,14-prostaglandin j232	7.3	TNF, IL8, IL6, IL1B, IL10, IFNG
35	herbimycin a32 42	8.2	TNF, IFNG, IL8, IL6, IL4, IL1A
36	etanercept32 9 9	9.2	IL10, IL1B, CRP, TNF, IFNG, IL6
37	infliximab32 9 9	9.1	CRP, TNF, IFNG, IL6, IL1R1, IL1B
38	ccl332	7.0	TNF, IFNG, CCL20, IL8, IL1R1, IL10
39	indomethacin32 9 9	9.0	LTF, EGF, TNF, IFNG, IL6, IL4
40	il-1232	7.0	IL6, IL8, IL1R1, IL1B, TNF, IFNG
41	il 1032	7.0	IL10, IL1A, IL1B, IL1R1, IL4, IL6
42	gm-csf32	6.9	IFNG, IL8, IL6, IL1B, IL1A, IL10
43	polymyxin b32	6.9	LTF, TNF, IFNG, IL8, IL6, IL4
44	actinomycin d32	6.7	IL1A, LTF, TNF, IL8, IL6, IFNG
45	pentoxifylline32 9 9	8.4	ELANE, LTF, TNF, IFNG, IL8, IL6
46	thymidine32 18	7.3	IL1A, IL4, EGF, IL6, IFNG, IL1B
47	neopterin32	6.0	CRP, TNF, IFNG, IL8, IL6, IL4
48	hydrocortisone32 9 9	8.0	IL4, IL1R1, IL1B, IL1A, IL10, IL6
49	dexamethasone32 42 34 9 9	10.0	IL1A, LTF, TNF, IFNG, CCL20, IL8
50	cycloheximide32	5.9	IL10, INHBA, IL1B, IL6, IL8, IFNG

Cellular components related to intrauterine infections according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	secretory granule	GO:030141	9.3	IL1B, LTF, ELANE
2	external side of plasma membrane	GO:009897	8.0	TNF, HLA-DRB1, IFNG, IL4
3	extracellular region	GO:005576	5.8	MMP8, ELANE, INHBA, IL1A, IL1B, IL1R1
4	extracellular space	GO:005615	5.5	IL1B, IL10, IL1A, IL4, IL6, IL8

Biological processes related to intrauterine infections according to GeneDecks:

(show all 49)

id	Name	GO ID	Score	Top Affiliating Genes
1	neutrophil apoptotic process	GO:001781	10.5	IL6
2	negative regulation of chemokine biosynthetic process	GO:045079	10.2	ELANE, IL6
3	chronic inflammatory response to antigenic stimulus	GO:002439	10.2	IL1B
4	regulation of isotype switching	GO:045191	10.0	IL4, IL10
5	fever generation	GO:001660	10.0	IL1A, IL1B
6	type 2 immune response	GO:042092	9.9	IL10, IL4
7	response to ozone	GO:010193	9.9	IL1A, IL1B
8	response to L-ascorbic acid	GO:033591	9.8	IL1A, IL1B
9	receptor biosynthetic process	GO:032800	9.8	TNF, IL10
10	positive regulation of interleukin-8 biosynthetic process	GO:045416	9.7	TNF, ELANE
11	negative regulation of lipid storage	GO:010888	9.7	TNF, CRP, IL6
12	negative regulation of cytokine secretion involved in immune response	GO:002740	9.7	IL10, TNF
13	positive regulation of smooth muscle cell proliferation	GO:048661	9.7	ELANE, IL6, TNF
14	sequestering of triglyceride	GO:030730	9.7	IL1B, TNF
15	response to molecule of bacterial origin	GO:002237	9.7	IL8, IL10
16	positive regulation of heterotypic cell-cell adhesion	GO:034116	9.6	TNF, IL1B
17	positive regulation of MAP kinase activity	GO:043406	9.6	EGF, ELANE, TNF
18	positive regulation of cytokine secretion	GO:050715	9.6	IL1A, TNF, IL10
19	positive regulation of vitamin D biosynthetic process	GO:060557	9.5	TNF, IFNG
20	ovulation	GO:030728	9.5	IL1R1, IL1B
21	positive regulation of isotype switching to IgG isotypes	GO:048304	9.5	IL4, IFNG
22	positive regulation of fever generation	GO:031622	9.5	IL1B, TNF
23	positive regulation of JNK cascade	GO:046330	9.4	IL1A, IL1B, TNF
24	negative regulation of nitric oxide biosynthetic process	GO:045019	9.3	IL10, IL4
25	positive regulation of MHC class II biosynthetic process	GO:045348	9.2	IL4, IL10, IFNG
26	positive regulation of interleukin-6 production	GO:032755	9.2	IL1A, TNF, IL6, IL1B
27	positive regulation of interleukin-6 biosynthetic process	GO:045410	9.2	IL1B, IFNG
28	positive regulation of mitosis	GO:045840	9.1	IL1A, IL1B, TNF, EGF
29	neutrophil chemotaxis	GO:030593	9.1	IFNG, IL8, IL1B
30	immune response	GO:006955	9.1	HLA-DRB1, IL8, CCL20, IL1A, IL4, IL1R1
31	cellular response to lipopolysaccharide	GO:071222	9.1	IL10, IFNG, IL8
32	defense response to bacterium	GO:042742	9.0	LTF, IFNG, CCL20, IL10
33	response to hypoxia	GO:001666	9.0	IL1A, IL1B, CRP, TNF
34	humoral immune response	GO:006959	9.0	IFNG, IL6, LTF, TNF
35	positive regulation of calcidiol 1-monooxygenase activity	GO:060559	9.0	TNF, IFNG, IL1B
36	positive regulation of membrane protein ectodomain proteolysis	GO:051044	8.9	TNF, IFNG, IL1B
37	response to glucocorticoid stimulus	GO:051384	8.9	IL10, IL1B, IL6, TNF
38	positive regulation of nitric oxide biosynthetic process	GO:045429	8.9	IFNG, TNF, IL1B
39	positive regulation of T cell proliferation	GO:042102	8.8	IL4, IL6, IL1B, IFNG
40	negative regulation of growth of symbiont in host	GO:044130	8.8	ELANE, TNF, IFNG, IL10
41	negative regulation of cell proliferation	GO:008285	8.7	IL8, IL1B, IL6, TNF, IL1A, INHBA
42	anti-apoptosis	GO:006916	8.7	IL1B, TNF, IL10, IL1A
43	positive regulation of chemokine biosynthetic process	GO:045080	8.6	TNF, IFNG, IL4, IL1B
44	positive regulation of sequence-specific DNA binding transcription factor activity	GO:051091	8.6	TNF, IL6, IL4, IL1B, IL10
45	regulation of insulin secretion	GO:050796	8.5	TNF, IL1B, IFNG
46	cytokine-mediated signaling pathway	GO:019221	8.4	IL1A, IL1B, IL6, IFNG, HLA-DRB1
47	positive regulation of transcription, DNA-dependent	GO:045893	8.0	EGF, IL10, IL1B, IL4, IL6, TNF
48	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.8	IL1B, IL1A, IL4, IL6, INHBA, IFNG
49	inflammatory response	GO:006954	7.8	IL6, IL10, IL1A, IL1B, IL8, CCL20

Molecular functions related to intrauterine infections according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	protease binding	GO:002020	9.4	ELANE, TNF, IL1R1
2	growth factor activity	GO:008083	7.8	IL1B, IL4, IL6, IL10, INHBA, EGF
3	cytokine activity	GO:005125	6.8	IL6, TNF, IFNG, IL4, IL1B, IL1A