MCID: INT103
MIFTS: 36

Intrauterine Infections malady

Summaries for Intrauterine Infections

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63Wikipedia, 32MalaCards
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Wikipedia:63 A vertically transmitted infection is an infection caused by bacteria, viruses or, in rare cases,... more...

MalaCards: Intrauterine Infections is related to hepatitis and hepatitis b. An important gene associated with Intrauterine Infections is CLEC4M (C-type lectin domain family 4, member M), and among its related pathways are Prion diseases and Cytokines and Inflammatory Response. The compounds gabexate mesilate and indomethacin have been mentioned in the context of this disorder. Related mouse phenotypes are respiratory system and integument.

Aliases & Classifications for Intrauterine Infections

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42NIH Rare Diseases
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Aliases & Descriptions:

intrauterine infections 42


Related Diseases for Intrauterine Infections

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Intrauterine Infections:



Diseases related to intrauterine infections

Clinical Features for Intrauterine Infections

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Drugs & Therapeutics for Intrauterine Infections

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Intrauterine Infections

Drug clinical trials:

Search ClinicalTrials for Intrauterine Infections

Search NIH Clinical Center for Intrauterine Infections

Search CenterWatch for Intrauterine Infections

Genetic Tests for Intrauterine Infections

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Anatomical Context for Intrauterine Infections

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Animal Models for Intrauterine Infections or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Intrauterine Infections:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053889.7IL6, IL1R1, TERC
2MP:00107719.7IL6, IL1R1, DKC1, TERC
3MP:00053909.5IL6, IL4, IL1B
4MP:00053919.4EGF, IL1R1, INHBA
5MP:00053798.1TERC, EGF, INHBA, IL1R1, IL4, IL6
6MP:00020068.1MMP8, ELANE, IL6, TERC, IL1B, IL1R1
7MP:00053858.0IL6, IL1B, IL1A, IL10, CRP, IFNG
8MP:00053817.8IL10, TERC, IL6, IL4, INHBA, EGF
9MP:00053767.6LTF, DKC1, CRP, IFNG, TERC, CD209
10MP:00053977.0IFNG, DKC1, LTF, INHBA, IL10, IL1R1
11MP:00107686.6IL1R1, IL4, INHBA, CD209, DKC1, IFNG
12MP:00053876.1IFNG, ELANE, TERC, MMP8, IL6, IL1B

Publications for Intrauterine Infections

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Genetic Variations for Intrauterine Infections

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Expression for genes affiliated with Intrauterine Infections

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Intrauterine Infections

Search GEO for disease gene expression data for Intrauterine Infections.

Pathways for genes affiliated with Intrauterine Infections

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Sources:
29KEGG, 37NCBI BioSystems Database, 52R&D Systems, 53Reactome, 12EMD Millipore, 51QIAGEN, 4Cell Signaling Technology
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Pathways related to Intrauterine Infections according to GeneCards/GeneDecks:

(show top 50)    (show all 58)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2IL1A
210.0HLA-DRB1
3
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9.9IL1R1, IL6
49.8IL1B, IL1A
5
Transcription Role of VDR in regulation of genes involved in osteoporosis
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9.8IFNG, IL1A
69.8IL1B, IL4
79.8MMP8, ELANE, LTF
8
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9.7IL1A, HLA-DRB1
99.7CCL20
10
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9.6IL1R1, IL1A, IL1B
119.6IL8, INHBA
12
Development Thrombopoetin signaling via JAK-STAT pathway
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9.5IFNG, CRP, IL4
13
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9.5IL1A, IL4, IFNG
14
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9.4IL1R1, CCL20
159.4IL6, IL8, IFNG
169.3IFNG, IL4, IL10
17
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9.3CCL20, EGF
18
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9.3CCL20, EGF
19
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9.3IL1R1, IL1A, IL6, IL1B
20
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9.3IL1B, IL1A, IL1R1, IL6
219.2IL4, IL8, IL1B, IL6
229.1IL1A, IFNG, IL1R1, IL1B
239.1IL10, IL1A, IL1B, IL6
249.1IL4, IFNG, IL8, IL6
259.1IL6, IL1B, IFNG, CRP
26
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9.0IL1B, CD209, IL8, IL6, IL1R1
279.0IL4, IFNG, IL10, IL6
289.0IL6, IL1B, IL1R1, IL4, IL1A
298.9IL1A, HLA-DRB1, CD209, CLEC4M, IL10
308.9IL1B, IFNG, IL6, IL10
31
Development PDGF signaling via STATs and NF-kB
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8.9IFNG, IL6, IL1B, IL10
32
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8.9IL1B, IL6, IL10, IFNG
338.8IL6, IL1A, IL1B, IL10, IL8
348.8IL1A, IL8, IL6, IL1B, IL10
358.8IL6, IL8, IL1A, IL1B, IFNG
368.7IL6, IL8, IL4, CCL20
37
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8.6IFNG, IL1B, IL6, IL10, IL8
38
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8.6IL1B, IL1R1, HLA-DRB1, IFNG, IL4
39
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8.5IL1R1, IL6, IFNG, IL1B, IL1A, IL8
408.4IL6, HLA-DRB1, IL1R1, IL4, IL1A, IL1B
41
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8.4IL1A, INHBA, EGF, CCL20
428.4IL10, IL1R1, IL8, IL1B, IFNG, IL6
43
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8.3IL6, IFNG, HLA-DRB1, IL1R1, IL1B, IL1A
448.1IL1A, IL8, IL4, IL10, IFNG, IL6
45
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8.0IFNG, HLA-DRB1, IL1R1, EGF, IL4, IL1A
46
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7.9IFNG, HLA-DRB1, EGF, IL1R1, IL1A, IL1B
47
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7.8IL10, IL1A, HLA-DRB1, IL4, IFNG, IL6
48
Immune response Bacterial infections in normal airways
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7.7IL1A, IL8, IL1R1, IL6, IL1B, IFNG
49
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7.5IL1B, IFNG, IL6, HLA-DRB1, CD209, CLEC4M
50
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7.1IL6, IL1A, IL1R1, IL10, IL4, EGF

Compounds for genes affiliated with Intrauterine Infections

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 2BitterDB, 49PharmGKB, 24HMDB
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Compounds related to Intrauterine Infections according to GeneCards/GeneDecks:

(show top 50)    (show all 190)
idCompoundScoreTop Affiliating Genes
1gabexate mesilate4410.6ELANE
2indomethacin44 59 28 1113.4LTF, IL1R1
3rolipram44 59 2812.2ELANE
4tenidap44 2811.2IL1A, LTF, IL1R1
5hydrocortisone44 2 59 1113.1IL8, ELANE, LTF
6gm-csf44 2811.1IL10, IFNG
7aprotinin44 1110.9LTF, IL8, ELANE
8pentoxifylline44 1110.9ELANE, IL4, IL1R1, LTF
9endotoxin449.9LTF, CCL20
10ivig449.8IFNG, CRP, IL1R1, IL1A
11cyclosporin a44 28 5911.5MMP8, LTF, IL1R1, IFNG, ELANE
12anaphylatoxin449.4IL1B, IL8, IL4, ELANE
13adalimumab44 49 1111.2IL6, IL1R1, IL10, CRP, IFNG
14bucillamine449.2CRP, IFNG, IL1B, IL6
15mip 1alpha449.2IL6, IL10, IL4, IL8, IL1B
16sulfasalazine44 28 49 1112.1IL1R1, CRP, IL8, IL1B, IL1A
17imiquimod44 28 59 1112.1IL6, IL8, IL10, IFNG, IL1A
18dexamethasone44 49 28 1112.1CCL20, IL1R1, IL6, LTF, CD209
19groalpha449.1IL10, IL8, IL1A, IL1B, IL6
20anakinra44 1110.0IL6, IL1B, IL1R1, CRP
21okt3449.0IL6, IFNG, IL10, IL4, CRP
22budesonide44 49 1110.9IFNG, IL1B, IL8, LTF, IL4
23lipoteichoic acid448.9IL6, IL1B, IL10, IL8, IL1R1
24leukotriene b444 59 2410.9LTF, IL1B, IL6, ELANE, IL1A, IL8
25hyaluronic acid44 249.8LTF, IL1R1, IL8, IL1A, IL1B, IL6
26gold sodium thiomalate448.7IFNG, IL1B, IL1A, IL8, IL1R1, HLA-DRB1
27pdtc448.7IL8, IL1A, IL1B, IL6, IFNG, IL4
28thalidomide44 49 59 1111.7IL1B, IL6, IFNG, IL1R1, IL1A, IL10
29fluticasone propionate44 49 59 1111.7IL4, IL1B, IL8, IFNG, ELANE
3015-deoxy-delta-12,14-prostaglandin j2448.6IL6, IL4, IFNG, IL8, IL1B, IL10
31simvastatin44 49 59 28 11 2413.6IFNG, CRP, IL10, IL4, IL8, IL1A
32etanercept44 49 1110.6CRP, IFNG, IL10, IL1R1, IL8, IL1B
33infliximab44 49 1110.6IL10, IL1R1, CRP, IFNG, IL6, IL1B
34polyinosinic-polycytidylic acid448.5IL1A, IL1B, IFNG, IL6, IL4, IL10
35herbimycin a44 599.4IL6, IL1B, IL1A, EGF, IL8, IL4
36peptidoglycan44 289.4IL8, CCL20, IL1B, IL6, IL1R1, IL10
37tarc448.3CCL20, IL10, IL4, IFNG, IL1A, IL8
38il 10448.3IL1B, IL1A, IL4, IL1R1, IL10, IFNG
39polymyxin b448.3IL10, IFNG, LTF, IL4, IL8, IL1A
40calcitriol44 59 11 2411.3IL1A, IL6, IL1B, IL4, IL10, EGF
41poly(i-c)448.2IL1B, CCL20, IFNG, IL6, IL8, IL4
42rantes448.1CCL20, IFNG, IL1R1, IL4, IL1B, IL6
43actinomycin d448.0IL4, IL8, IL1A, IL1B, IFNG, EGF
44allergens448.0IL10, CLEC4M, CD209, HLA-DRB1, IFNG, CCL20
45thymidine44 248.9EGF, IL10, IL1B, IL1A, IL4, IL1R1
46ccl344 288.8IL8, IL1A, IL1R1, CCL20, IFNG, IL10
47il-12447.7IL1R1, IL10, IL6, IL1B, CCL20, IL8
48sb 20358044 598.7IL4, IL10, EGF, CRP, IFNG, IL1A
49neopterin447.6IL1R1, IL10, LTF, CRP, IFNG, IL4
50vegf446.4CCL20, MMP8, IFNG, IL1A, IL8, IL6

GO Terms for genes affiliated with Intrauterine Infections

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16Gene Ontology
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Cellular components related to Intrauterine Infections according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:0301419.6ELANE, IL1B, LTF
2external side of plasma membraneGO:0098978.6IFNG, HLA-DRB1, IL4, IL6
3extracellular spaceGO:0056156.4CCL20, IFNG, CRP, EGF, IL10, IL4
4extracellular regionGO:0055765.4ELANE, CCL20, IFNG, CRP, EGF, LTF

Biological processes related to Intrauterine Infections according to GeneCards/GeneDecks:

(show all 37)
idNameGO IDScoreTop Affiliating Genes
1intracellular virion transportGO:04679510.4CD209, CLEC4M
2viral attachment to host cellGO:01906210.4CD209, CLEC4M
3peptide antigen transportGO:04696810.4CD209, CLEC4M
4cell-cell recognitionGO:00998810.3CD209, CLEC4M
5negative regulation of chemokine biosynthetic processGO:04507910.2IL6, ELANE
6fever generationGO:00166010.1IL1A, IL1B
7regulation of isotype switchingGO:04519110.1IL10, IL4
8viral genome replicationGO:01907910.1CLEC4M, CD209
9negative regulation of lipid storageGO:01088810.0CRP, IL6
10type 2 immune responseGO:04209210.0IL10, IL4
11antigen processing and presentationGO:01988210.0IFNG, CD209, CLEC4M
12neutrophil apoptotic processGO:00178110.0IFNG, IL6
13positive regulation of calcidiol 1-monooxygenase activityGO:0605599.9IFNG, IL1B
14positive regulation of isotype switching to IgG isotypesGO:0483049.9IL4, IFNG
15positive regulation of mitosisGO:0458409.8IL1B, IL1A, EGF
16response to molecule of bacterial originGO:0022379.8IL8, IL10
17defense response to protozoanGO:0428329.8IL6, IL4, IFNG
18negative regulation of growth of symbiont in hostGO:0441309.8IFNG, IL10, ELANE
19positive regulation of interleukin-6 biosynthetic processGO:0454109.8IFNG, IL1B
20positive regulation of MHC class II biosynthetic processGO:0453489.8IFNG, IL10, IL4
21positive regulation of chemokine biosynthetic processGO:0450809.7IL1B, IL4, IFNG
22humoral immune responseGO:0069599.7IFNG, LTF, IL6
23positive regulation of nitric oxide biosynthetic processGO:0454299.6IFNG, IL1B, IL6
24neutrophil chemotaxisGO:0305939.6IL1B, IL8, IFNG
25negative regulation of nitric oxide biosynthetic processGO:0450199.5IL4, IL10
26positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.5IL10, IL4, IL1B, IL6
27cellular response to lipopolysaccharideGO:0712229.4IL8, IL10, IFNG
28positive regulation of T cell proliferationGO:0421029.4IL6, IL1B, IL4, IFNG
29defense response to bacteriumGO:0427428.9IL10, LTF, IFNG, CCL20
30cytokine-mediated signaling pathwayGO:0192218.9IL6, IL1B, IL1A, HLA-DRB1, IFNG
31negative regulation of cell proliferationGO:0082858.8IL6, IL1B, IL1A, IL8, INHBA
32response to drugGO:0424938.8IFNG, INHBA, IL10, IL4, IL6
33positive regulation of transcription, DNA-dependentGO:0458938.5EGF, INHBA, IL10, IL4, IL1B, IL6
34inflammatory responseGO:0069548.2IL6, CCL20, CRP, IL10, IL8, IL1A
35cell-cell signalingGO:0072678.1CCL20, INHBA, IL10, IL1B
36positive regulation of transcription from RNA polymerase II promoterGO:0459448.1IFNG, INHBA, IL10, IL4, IL1A, IL1B
37immune responseGO:0069558.1CCL20, HLA-DRB1, IL1R1, IL4, IL8, IL1A

Molecular functions related to Intrauterine Infections according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1virion bindingGO:04679010.1CLEC4M, CD209
2peptide antigen bindingGO:0426059.3CLEC4M, CD209, HLA-DRB1
3growth factor activityGO:0080838.4EGF, INHBA, IL10, IL4, IL6
4cytokine activityGO:0051257.7IL6, IL1B, IL1A, IL4, IL10, INHBA

Products for genes affiliated with Intrauterine Infections

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  • Antibodies
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Sources for Intrauterine Infections

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet