MCID: INT103
MIFTS: 41

Intrauterine Infections malady

Summaries for Intrauterine Infections

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 A vertically transmitted infection is an infection caused by bacteria, viruses or, in rare cases,... more...

MalaCards: Intrauterine Infections is related to hepatitis c and pseudo-torch syndrome. An important gene associated with Intrauterine Infections is CLEC4M (C-type lectin domain family 4, member M), and among its related pathways are Prion diseases and Cytokines and Inflammatory Response. The compounds gabexate mesilate and indomethacin have been mentioned in the context of this disorder. Affiliated tissues include ovary and b cells, and related mouse phenotypes are respiratory system and integument.

Aliases & Classifications for Intrauterine Infections

Sources:
43NIH Rare Diseases
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Aliases & Descriptions:

intrauterine infections 43


Related Diseases for Intrauterine Infections

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Intrauterine Infections:



Diseases related to intrauterine infections

Clinical Features for Intrauterine Infections

Drugs & Therapeutics for Intrauterine Infections

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Intrauterine Infections

Drug clinical trials:

Search ClinicalTrials for Intrauterine Infections

Search NIH Clinical Center for Intrauterine Infections

Search CenterWatch for Intrauterine Infections

Genetic Tests for Intrauterine Infections

Anatomical Context for Intrauterine Infections

Sources:
33MalaCards
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MalaCards organs/tissues related to Intrauterine Infections:

33
Ovary, B cells

Animal Models for Intrauterine Infections or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Intrauterine Infections

Sources:
51PubMed
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Articles related to Intrauterine Infections:

(show all 33)
idTitleAuthorsYear
1
Eye manifestations of intrauterine infections and their impact on childhood blindness. (18348876)
2008
2
Fetal manifestations and poor outcomes of congenital cytomegalovirus infections: possible candidates for intrauterine antiviral treatments. (17845318)
2007
3
The possible role of intrauterine infections in unexplained second trimester abortions and macerated stillbirths: a study from a single center. (15254560)
2004
4
Intrauterine infections. (15490912)
2004
5
Intrauterine infections and birth defects. (15745253)
2004
6
Intrauterine infections: a literature review. (15552342)
2004
7
Eye manifestations of intrauterine infections. (11705152)
2001
8
Incidence, clinical spectrum, and outcome of intrauterine infections in neonates. (10893916)
2000
9
Intrauterine infections. I. The role of C-reactive protein, white blood cell count and erythrocyte sedimentation rate in pregnant women in the detection of intrauterine infection after preliminary rupture of membranes]. (9813940)
1998
10
Pathogenesis of intrauterine infections with bovine viral diarrhea virus. (8581858)
1995
11
Low amniotic fluid glucose levels are a specific but not a sensitive marker for subclinical intrauterine infections in patients in preterm labor with intact membranes. (8059814)
1994
12
The TORCH screen and intrauterine infections. (8198407)
1994
13
Intrauterine infections and their association with stillbirth and preterm birth in Maputo, Mozambique. (8449441)
1993
14
CD5+ B cells in normal newborns and infants, and in those with HIV and intrauterine infections. (1376079)
1992
15
IgA-secreting cells in the blood of premature and term infants: normal development and effect of intrauterine infections. (1809028)
1991
16
Erythromycin therapy for subclinical intrauterine infections in threatened preterm delivery--a preliminary report. (3210111)
1988
17
Influence of intrauterine infections and follicular development on the response to GnRH administration in postpartum dairy cows. (16726440)
1988
18
Evidence for a role of intrauterine infections in the pathogenesis of cystic ovaries in postpartum dairy cows. (16726355)
1987
19
Therapeutic effects of imipenem-cilastatin on experimental intrauterine infections in rats. (3111355)
1987
20
Intrauterine infections. (3836968)
1985
21
Intrauterine infections with group B beta-haemolytic streptococci. (6367810)
1984
22
Ascending intrauterine infections in rhesus monkeys. (7174462)
1982
23
Eye findings in intrauterine infections. (6273047)
1981
24
Ampicillin and gemtamicin in the treatment of fetal intrauterine infections. (7365666)
1980
25
Intrauterine infections in nonhuman primates. (119050)
1979
26
Intrauterine infections induced by mumps virus in hamsters. (4602053)
1974
27
Pathogenesis of intrauterine infections in rats due to reovirus type 3. I. Virologic studies. (4349899)
1973
28
Intrauterine infections: problems and prevention. (4123409)
1973
29
Pathogenesis of intrauterine infections in rats due to reovirus type 3. II. Pathologic and fluorescent antibody studies. (4122105)
1973
30
Intrauterine infections: chairman's summary. (4349343)
1972
31
Intrauterine infections: introduction. (4488019)
1972
32
Elevated cord macroglobulins in the diagnosis of intrauterine infections. (4162280)
1966
33
MOUSE CYTOMEGALOVIRUS INFECTION. 3. ATTEMPTS TO PRODUCE INTRAUTERINE INFECTIONS. (14196040)
1964

Genetic Variations for Intrauterine Infections

Expression for genes affiliated with Intrauterine Infections

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Intrauterine Infections

Search GEO for disease gene expression data for Intrauterine Infections.

Pathways for genes affiliated with Intrauterine Infections

Sources:
30KEGG, 38NCBI BioSystems Database, 53R&D Systems, 54Reactome, 12EMD Millipore, 52QIAGEN, 4Cell Signaling Technology
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Pathways related to Intrauterine Infections according to GeneCards/GeneDecks:

(show top 50)    (show all 58)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2IL1A
210.0HLA-DRB1
3
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9.9IL1R1, IL6
49.8IL1B, IL1A
5
Transcription Role of VDR in regulation of genes involved in osteoporosis
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9.8IFNG, IL1A
69.8IL1B, IL4
79.8MMP8, ELANE, LTF
8
Hide members
9.7IL1A, HLA-DRB1
99.7CCL20
10
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9.6IL1R1, IL1A, IL1B
119.6IL8, INHBA
12
Development Thrombopoetin signaling via JAK-STAT pathway
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9.5IFNG, CRP, IL4
13
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9.5IL1A, IL4, IFNG
14
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9.4IL1R1, CCL20
159.4IL6, IL8, IFNG
169.3IFNG, IL4, IL10
17
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9.3CCL20, EGF
18
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9.3CCL20, EGF
19
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9.3IL1R1, IL1A, IL6, IL1B
20
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9.3IL1B, IL1A, IL1R1, IL6
219.2IL4, IL8, IL1B, IL6
229.1IL1A, IFNG, IL1R1, IL1B
239.1IL10, IL1A, IL1B, IL6
249.1IL4, IFNG, IL8, IL6
259.1IL6, IL1B, IFNG, CRP
26
Hide members
9.0IL1B, CD209, IL8, IL6, IL1R1
279.0IL4, IFNG, IL10, IL6
289.0IL6, IL1B, IL1R1, IL4, IL1A
298.9IL1A, HLA-DRB1, CD209, CLEC4M, IL10
308.9IL1B, IFNG, IL6, IL10
31
Development PDGF signaling via STATs and NF-kB
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8.9IFNG, IL6, IL1B, IL10
32
Hide members
8.9IL1B, IL6, IL10, IFNG
338.8IL6, IL1A, IL1B, IL10, IL8
348.8IL1A, IL8, IL6, IL1B, IL10
358.8IL6, IL8, IL1A, IL1B, IFNG
368.7IL6, IL8, IL4, CCL20
37
Hide members
8.6IFNG, IL1B, IL6, IL10, IL8
38
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8.6IL1B, IL1R1, HLA-DRB1, IFNG, IL4
39
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8.5IL1R1, IL6, IFNG, IL1B, IL1A, IL8
408.4IL6, HLA-DRB1, IL1R1, IL4, IL1A, IL1B
41
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8.4IL1A, INHBA, EGF, CCL20
428.4IL10, IL1R1, IL8, IL1B, IFNG, IL6
43
Hide members
8.3IL6, IFNG, HLA-DRB1, IL1R1, IL1B, IL1A
448.1IL1A, IL8, IL4, IL10, IFNG, IL6
45
Hide members
8.0IFNG, HLA-DRB1, IL1R1, EGF, IL4, IL1A
46
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7.9IFNG, HLA-DRB1, EGF, IL1R1, IL1A, IL1B
47
Hide members
7.8IL10, IL1A, HLA-DRB1, IL4, IFNG, IL6
48
Immune response Bacterial infections in normal airways
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7.7IL1A, IL8, IL1R1, IL6, IL1B, IFNG
49
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7.5IL1B, IFNG, IL6, HLA-DRB1, CD209, CLEC4M
50
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7.1IL6, IL1A, IL1R1, IL10, IL4, EGF

Compounds for genes affiliated with Intrauterine Infections

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 2BitterDB, 50PharmGKB, 24HMDB
See all sources

Compounds related to Intrauterine Infections according to GeneCards/GeneDecks:

(show top 50)    (show all 190)
idCompoundScoreTop Affiliating Genes
1gabexate mesilate4510.6ELANE
2indomethacin45 60 29 1113.4LTF, IL1R1
3rolipram45 60 2912.2ELANE
4tenidap45 2911.2IL1A, LTF, IL1R1
5hydrocortisone45 2 60 1113.1IL8, ELANE, LTF
6gm-csf45 2911.1IL10, IFNG
7aprotinin45 1110.9LTF, IL8, ELANE
8pentoxifylline45 1110.9ELANE, IL4, IL1R1, LTF
9endotoxin459.9LTF, CCL20
10ivig459.8IFNG, CRP, IL1R1, IL1A
11cyclosporin a45 29 6011.5MMP8, LTF, IL1R1, IFNG, ELANE
12anaphylatoxin459.4IL1B, IL8, IL4, ELANE
13adalimumab45 50 1111.2IL6, IL1R1, IL10, CRP, IFNG
14bucillamine459.2CRP, IFNG, IL1B, IL6
15mip 1alpha459.2IL6, IL10, IL4, IL8, IL1B
16sulfasalazine45 29 50 1112.1IL1R1, CRP, IL8, IL1B, IL1A
17imiquimod45 29 60 1112.1IL6, IL8, IL10, IFNG, IL1A
18dexamethasone45 50 29 1112.1CCL20, IL1R1, IL6, LTF, CD209
19groalpha459.1IL10, IL8, IL1A, IL1B, IL6
20anakinra45 1110.0IL6, IL1B, IL1R1, CRP
21okt3459.0IL6, IFNG, IL10, IL4, CRP
22budesonide45 50 1110.9IFNG, IL1B, IL8, LTF, IL4
23lipoteichoic acid458.9IL6, IL1B, IL10, IL8, IL1R1
24leukotriene b445 60 2410.9LTF, IL1B, IL6, ELANE, IL1A, IL8
25hyaluronic acid45 249.8LTF, IL1R1, IL8, IL1A, IL1B, IL6
26gold sodium thiomalate458.7IFNG, IL1B, IL1A, IL8, IL1R1, HLA-DRB1
27pdtc458.7IL8, IL1A, IL1B, IL6, IFNG, IL4
28thalidomide45 50 60 1111.7IL1B, IL6, IFNG, IL1R1, IL1A, IL10
29fluticasone propionate45 50 60 1111.7IL4, IL1B, IL8, IFNG, ELANE
3015-deoxy-delta-12,14-prostaglandin j2458.6IL6, IL4, IFNG, IL8, IL1B, IL10
31simvastatin45 50 60 29 11 2413.6IFNG, CRP, IL10, IL4, IL8, IL1A
32etanercept45 50 1110.6CRP, IFNG, IL10, IL1R1, IL8, IL1B
33infliximab45 50 1110.6IL10, IL1R1, CRP, IFNG, IL6, IL1B
34polyinosinic-polycytidylic acid458.5IL1A, IL1B, IFNG, IL6, IL4, IL10
35herbimycin a45 609.4IL6, IL1B, IL1A, EGF, IL8, IL4
36peptidoglycan45 299.4IL8, CCL20, IL1B, IL6, IL1R1, IL10
37tarc458.3CCL20, IL10, IL4, IFNG, IL1A, IL8
38il 10458.3IL1B, IL1A, IL4, IL1R1, IL10, IFNG
39polymyxin b458.3IL10, IFNG, LTF, IL4, IL8, IL1A
40calcitriol45 60 11 2411.3IL1A, IL6, IL1B, IL4, IL10, EGF
41poly(i-c)458.2IL1B, CCL20, IFNG, IL6, IL8, IL4
42rantes458.1CCL20, IFNG, IL1R1, IL4, IL1B, IL6
43actinomycin d458.0IL4, IL8, IL1A, IL1B, IFNG, EGF
44allergens458.0IL10, CLEC4M, CD209, HLA-DRB1, IFNG, CCL20
45thymidine45 248.9EGF, IL10, IL1B, IL1A, IL4, IL1R1
46ccl345 298.8IL8, IL1A, IL1R1, CCL20, IFNG, IL10
47il-12457.7IL1R1, IL10, IL6, IL1B, CCL20, IL8
48sb 20358045 608.7IL4, IL10, EGF, CRP, IFNG, IL1A
49neopterin457.6IL1R1, IL10, LTF, CRP, IFNG, IL4
50vegf456.4CCL20, MMP8, IFNG, IL1A, IL8, IL6

GO Terms for genes affiliated with Intrauterine Infections

Sources:
16Gene Ontology
See all sources

Cellular components related to Intrauterine Infections according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:0301419.6ELANE, IL1B, LTF
2external side of plasma membraneGO:0098978.6IFNG, HLA-DRB1, IL4, IL6
3extracellular spaceGO:0056156.4CCL20, IFNG, CRP, EGF, IL10, IL4
4extracellular regionGO:0055765.4ELANE, CCL20, IFNG, CRP, EGF, LTF

Biological processes related to Intrauterine Infections according to GeneCards/GeneDecks:

(show all 37)
idNameGO IDScoreTop Affiliating Genes
1intracellular virion transportGO:04679510.4CD209, CLEC4M
2viral attachment to host cellGO:01906210.4CD209, CLEC4M
3peptide antigen transportGO:04696810.4CD209, CLEC4M
4cell-cell recognitionGO:00998810.3CD209, CLEC4M
5negative regulation of chemokine biosynthetic processGO:04507910.2IL6, ELANE
6fever generationGO:00166010.1IL1A, IL1B
7regulation of isotype switchingGO:04519110.1IL10, IL4
8viral genome replicationGO:01907910.1CLEC4M, CD209
9negative regulation of lipid storageGO:01088810.0CRP, IL6
10type 2 immune responseGO:04209210.0IL10, IL4
11antigen processing and presentationGO:01988210.0IFNG, CD209, CLEC4M
12neutrophil apoptotic processGO:00178110.0IFNG, IL6
13positive regulation of calcidiol 1-monooxygenase activityGO:0605599.9IFNG, IL1B
14positive regulation of isotype switching to IgG isotypesGO:0483049.9IL4, IFNG
15positive regulation of mitosisGO:0458409.8IL1B, IL1A, EGF
16response to molecule of bacterial originGO:0022379.8IL8, IL10
17defense response to protozoanGO:0428329.8IL6, IL4, IFNG
18negative regulation of growth of symbiont in hostGO:0441309.8IFNG, IL10, ELANE
19positive regulation of interleukin-6 biosynthetic processGO:0454109.8IFNG, IL1B
20positive regulation of MHC class II biosynthetic processGO:0453489.8IFNG, IL10, IL4
21positive regulation of chemokine biosynthetic processGO:0450809.7IL1B, IL4, IFNG
22humoral immune responseGO:0069599.7IFNG, LTF, IL6
23positive regulation of nitric oxide biosynthetic processGO:0454299.6IFNG, IL1B, IL6
24neutrophil chemotaxisGO:0305939.6IL1B, IL8, IFNG
25negative regulation of nitric oxide biosynthetic processGO:0450199.5IL4, IL10
26positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.5IL10, IL4, IL1B, IL6
27cellular response to lipopolysaccharideGO:0712229.4IL8, IL10, IFNG
28positive regulation of T cell proliferationGO:0421029.4IL6, IL1B, IL4, IFNG
29defense response to bacteriumGO:0427428.9IL10, LTF, IFNG, CCL20
30cytokine-mediated signaling pathwayGO:0192218.9IL6, IL1B, IL1A, HLA-DRB1, IFNG
31negative regulation of cell proliferationGO:0082858.8IL6, IL1B, IL1A, IL8, INHBA
32response to drugGO:0424938.8IFNG, INHBA, IL10, IL4, IL6
33positive regulation of transcription, DNA-dependentGO:0458938.5EGF, INHBA, IL10, IL4, IL1B, IL6
34inflammatory responseGO:0069548.2IL6, CCL20, CRP, IL10, IL8, IL1A
35cell-cell signalingGO:0072678.1CCL20, INHBA, IL10, IL1B
36positive regulation of transcription from RNA polymerase II promoterGO:0459448.1IFNG, INHBA, IL10, IL4, IL1A, IL1B
37immune responseGO:0069558.1CCL20, HLA-DRB1, IL1R1, IL4, IL8, IL1A

Molecular functions related to Intrauterine Infections according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1virion bindingGO:04679010.1CLEC4M, CD209
2peptide antigen bindingGO:0426059.3CLEC4M, CD209, HLA-DRB1
3growth factor activityGO:0080838.4EGF, INHBA, IL10, IL4, IL6
4cytokine activityGO:0051257.7IL6, IL1B, IL1A, IL4, IL10, INHBA

Products for genes affiliated with Intrauterine Infections

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Intrauterine Infections

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet