MCID: INT221
MIFTS: 40

Intravascular Large B-Cell Lymphoma malady

Blood diseases, Cancer diseases, Immune diseases categories

Summaries for Intravascular Large B-Cell Lymphoma

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MalaCards: Intravascular Large B-Cell Lymphoma, also known as angioendotheliomatosis proliferans systemisata, is related to prostatitis and central nervous system lymphoma. An important gene associated with Intravascular Large B-Cell Lymphoma is BCL6 (B-cell CLL/lymphoma 6), and among its related pathways are IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types and B Cell Receptor Signaling Pathway. The compounds erythromycin and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include b cells, and related mouse phenotypes are tumorigenesis and reproductive system.

Aliases & Classifications for Intravascular Large B-Cell Lymphoma

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48Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases, Immune diseases


Aliases & Descriptions:

intravascular large b-cell lymphoma 48
angioendotheliomatosis proliferans systemisata 48
malignant angioendotheliomatosis 48
angiotropic large cell lymphoma 48
intravascular lymphomatosis 48
tappeiner-pfleger disease 48


External Ids:

ICD10 via Orphanet26 C83.3
SNOMED-CT via Orphanet57 399648005

Related Diseases for Intravascular Large B-Cell Lymphoma

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Intravascular Large B-Cell Lymphoma:



Diseases related to intravascular large b-cell lymphoma

Clinical Features for Intravascular Large B-Cell Lymphoma

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Drugs & Therapeutics for Intravascular Large B-Cell Lymphoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Intravascular Large B-Cell Lymphoma

Drug clinical trials:

Search ClinicalTrials for Intravascular Large B-Cell Lymphoma

Search NIH Clinical Center for Intravascular Large B-Cell Lymphoma

Search CenterWatch for Intravascular Large B-Cell Lymphoma

Genetic Tests for Intravascular Large B-Cell Lymphoma

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Anatomical Context for Intravascular Large B-Cell Lymphoma

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32MalaCards
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MalaCards organs/tissues related to Intravascular Large B-Cell Lymphoma:

32
B cells

Animal Models for Intravascular Large B-Cell Lymphoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Intravascular Large B-Cell Lymphoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.0KMT2A, CCND1, CXCR3
2MP:00053899.0CCND1, IL2RB, KMT2A, BCL2
3MP:00053768.6B2M, BCL6, KMT2A, CXCR3
4MP:00107718.5ACPP, KMT2A, MME, CCND1, BCL2
5MP:00053708.3IL2RB, MME, KMT2A, BCL6, B2M
6MP:00053857.7BCL6, KMT2A, CXCR3, MPO, B2M, CCND1
7MP:00053847.3CCND1, B2M, CD5, BCL2, BCL6, KMT2A
8MP:00107687.2BCL6, BCL2, KMT2A, IL2RB, IL2RA, CXCR3
9MP:00053976.7BCL2, BCL6, KMT2A, IL2RB, IL2RA, CD5
10MP:00053875.8TNFRSF8, IL2RB, MME, KMT2A, B2M, BCL6

Publications for Intravascular Large B-Cell Lymphoma

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Genetic Variations for Intravascular Large B-Cell Lymphoma

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Expression for genes affiliated with Intravascular Large B-Cell Lymphoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Intravascular Large B-Cell Lymphoma

Search GEO for disease gene expression data for Intravascular Large B-Cell Lymphoma.

Pathways for genes affiliated with Intravascular Large B-Cell Lymphoma

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Sources:
52R&D Systems, 37NCBI BioSystems Database, 12EMD Millipore, 29KEGG, 51QIAGEN, 55SinoBiological, 4Cell Signaling Technology
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Pathways related to Intravascular Large B-Cell Lymphoma according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.9IL2RA, IL2RB
29.7CD5, BCL2, BCL6
39.6IL2RB, BCL2, IL2RA
4
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9.6IL2RA, BCL2, IL2RB
5
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9.6IL2RB, IL2RA, BCL2
69.5BCL6, BCL2, CCND1
7
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9.5BCL6, CCND1, BCL2
89.5MME, CD5, IL2RA
9
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9.4IL2RB, CCND1, IL2RA
109.4CCND1, IL2RB, IL2RA
119.4CCND1, BCL2, MPO
12
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9.4B2M, IL2RB, IL2RA
139.4IL2RB, IL2RA, B2M
149.2IL2RA, IL2RB, CCND1, BCL2
15
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9.2BCL2, IL2RB, IL2RA, CCND1
169.0BCL6, KMT2A, IL2RB, MPO
17
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8.9B2M, BCL2, TNFRSF8
18
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8.5TNFRSF8, CXCR3, IL2RA, BCL2
198.4B2M, IL2RA, IL2RB, MME, BCL6, MPO
20
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8.2BCL2, IL2RB, IL2RA, CXCR3, TNFRSF8
21
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7.8BCL2, IL2RB, CXCR3, TNFRSF8, CCND1, IL2RA
22
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7.8CXCR3, BCL2, IL2RB, IL2RA, TNFRSF8, CCND1

Compounds for genes affiliated with Intravascular Large B-Cell Lymphoma

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Sources:
44Novoseek, 49PharmGKB, 2BitterDB, 11DrugBank, 28IUPHAR, 24HMDB, 59Tocris Bioscience
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Compounds related to Intravascular Large B-Cell Lymphoma according to GeneCards/GeneDecks:

(show top 50)    (show all 87)
idCompoundScoreTop Affiliating Genes
1erythromycin44 49 2 1113.2IL2RA
2cycloheximide4410.2MME, IL2RB
3lentinan4410.2IL2RB, IL2RA
4mycophenolate4410.2IL2RA, IL2RB
5thymoglobulin4410.0IL2RB, IL2RA
6ginsenoside449.9CCND1, BCL2, MME
7cuprophan449.8IL2RA, IL2RB, B2M
8polysulfone449.8IL2RB, IL2RA, B2M
92-chlorodeoxyadenosine449.7BCL2, B2M, IL2RA
102,5-oligoadenylate449.7IL2RB, IL2RA, B2M
11methacholine44 1110.6MME, IL2RB, MPO
12methimazole44 2 1111.6IL2RA, MPO, B2M
13rituximab44 49 1111.6B2M, BCL6, BCL2, IL2RA
14il 10449.5IL2RB, CXCR3, IL2RA
15estrogen449.5KMT2A, BCL6, ACPP
16pentoxifylline44 1110.5MPO, IL2RA, IL2RB
17infliximab44 49 1111.5IL2RB, IL2RA, CXCR3
18ricin449.5IL2RB, CD5, TNFRSF8
19adriamycin449.4B2M, CCND1, MME, BCL2
20prednisolone44 28 1111.3MPO, IL2RA, KMT2A, IL2RB
21formaldehyde44 2410.2MPO, IL2RA, CCND1, B2M
22ifn-alpha449.2CXCR3, IL2RB, IL2RA
23chloride449.2MPO, MME, IL2RB, B2M
24tacrolimus44 49 1111.2IL2RA, IL2RB, CXCR3, CCND1
25n acetylcysteine449.2BCL2, CCND1, IL2RB, IL2RA, MPO
26neopterin449.2ACPP, B2M, IL2RA, IL2RB
27creatinine449.1MME, ACPP, CXCR3, IL2RB
28ricin a449.0TNFRSF8, IL2RA
29histamine44 28 2411.0CXCR3, IL2RA, MME, IL2RB, MPO
30cyclophosphamide44 49 1110.9IL2RB, MPO, BCL2, IL2RA, BCL6, B2M
31aspartate448.8KMT2A, ACPP, B2M, IL2RB
32vincristine44 49 1110.7KMT2A, IL2RA, B2M, BCL6, CCND1, BCL2
33phosphatidylinositol448.6IL2RB, BCL2, IL2RA, CXCR3, CCND1, MME
34genistein44 28 59 2 11 2413.6B2M, IL2RB, BCL2, IL2RA, CCND1, KMT2A
35cyclosporin a44 28 5910.5TNFRSF8, IL2RB, B2M, MME, IL2RA
36lactate448.5MME, ACPP, BCL6, IL2RB, MPO, B2M
37progesterone44 59 28 11 2412.4BCL2, ACPP, MME, IL2RB, CXCR3, CCND1
38doxorubicin44 49 1110.3CCND1, IL2RA, MME, KMT2A, BCL2, BCL6
39testosterone44 59 11 2411.3ACPP, MME, IL2RA, B2M, CCND1
40arginine448.2MME, ACPP, CXCR3, KMT2A, IL2RA, IL2RB
41cisplatin44 49 59 1111.2ACPP, BCL2, CCND1, B2M, MPO, IL2RA
42retinoic acid44 249.0CCND1, B2M, MPO, MME, KMT2A, BCL6
43steroid447.9CXCR3, IL2RA, B2M, MME, ACPP, IL2RB
44serine447.7KMT2A, B2M, MPO, CXCR3, IL2RB, ACPP
45zinc44 248.7IL2RB, BCL6, ACPP, KMT2A, MME, IL2RA
46vegf447.3CCND1, B2M, MPO, CXCR3, IL2RA, IL2RB
47thymidine44 248.1CCND1, TNFRSF8, B2M, CXCR3, ACPP, MME
48calcium44 49 11 2410.0B2M, CD5, CXCR3, IL2RB, ACPP, MME
49paraffin446.8TNFRSF8, ACPP, BCL6, BCL2, MME, IL2RA
50tyrosine446.5TNFRSF8, CD5, MME, CXCR3, IL2RA, IL2RB

GO Terms for genes affiliated with Intravascular Large B-Cell Lymphoma

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16Gene Ontology
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Cellular components related to Intravascular Large B-Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.3B2M, CD5, CXCR3, IL2RA, IL2RB
2plasma membraneGO:0058866.8TNFRSF8, B2M, CD5, CXCR3, IL2RA, IL2RB

Biological processes related to Intravascular Large B-Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to DNA damage stimulusGO:0069749.5BCL2, BCL6, CCND1
2response to iron ionGO:0100399.5BCL2, CCND1

Molecular functions related to Intravascular Large B-Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-2 receptor activityGO:0049119.8IL2RB, IL2RA
2interleukin-2 bindingGO:0199769.6IL2RB, IL2RA
3identical protein bindingGO:0428028.6BCL2, ACPP, KMT2A, B2M

Products for genes affiliated with Intravascular Large B-Cell Lymphoma

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Sources for Intravascular Large B-Cell Lymphoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet