MCID: INT221
MIFTS: 44

Intravascular Large B-Cell Lymphoma malady

Blood, Cancer, Immune categories

Summaries for Intravascular Large B-Cell Lymphoma

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33MalaCards
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MalaCards: Intravascular Large B-Cell Lymphoma, also known as angioendotheliomatosis proliferans systemisata, is related to lymphoma, diffuse large cell and central nervous system lymphoma. An important gene associated with Intravascular Large B-Cell Lymphoma is BCL6 (B-cell CLL/lymphoma 6), and among its related pathways are IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types and B Cell Receptor Signaling Pathway. The compounds erythromycin and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, spleen and brain, and related mouse phenotypes are tumorigenesis and reproductive system.

Aliases & Classifications for Intravascular Large B-Cell Lymphoma

Sources:
49Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Blood, Immune


Aliases & Descriptions:

intravascular large b-cell lymphoma 49
angioendotheliomatosis proliferans systemisata 49
malignant angioendotheliomatosis 49
angiotropic large cell lymphoma 49
intravascular lymphomatosis 49
tappeiner-pfleger disease 49


External Ids:

ICD10 via Orphanet26 C83.3
SNOMED-CT via Orphanet58 399648005

Related Diseases for Intravascular Large B-Cell Lymphoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Intravascular Large B-Cell Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 175)
idRelated DiseaseScoreTop Affiliating Genes
1lymphoma, diffuse large cell30.9BCL2, BCL6, MME, TNFRSF8
2central nervous system lymphoma30.8BCL6
3systemic lupus erythematosus30.4IL2RB, IL2RA, CXCR3, MPO
4anaplastic large cell lymphoma30.4TNFRSF8, CXCR3, IL2RA, IL2RB, BCL6
5bone lymphoma10.8
6lung lymphoma10.7
7cerebral lymphoma10.7
8liver lymphoma10.5
9senile angioma10.5
10prostate lymphoma10.5
11colon lymphoma10.5
12pancytopenia10.5
13breast lymphoma10.5
14malignant histiocytosis10.3
15mononeuritis multiplex10.3
16protein-losing enteropathy10.3
17vasculitis10.3
18superior vena cava syndrome10.3
19myoma10.3
20thyroid lymphoma10.3
21testicular lymphoma10.3
22sagittal sinus thrombosis10.3
23west syndrome10.3
24splenic infarction10.3
25n syndrome10.3
26thrombocytopenia10.3
27adult respiratory distress syndrome10.2
28acute disseminated encephalomyelitis10.2
29kaposi's sarcoma10.2
30pseudobulbar palsy10.2
31cauda equina syndrome10.2
32adult syndrome10.2
33adult lymphoma10.2
34central nervous system lymphoma, primary10.2
35mycobacterium marinum10.2
36primary malignant lymphoma10.2
37hepatitis10.0IL2RB
38mastocytosis10.0IL2RA
39prostatitis10.0ACPP
40thymoma10.0CD5
41malaria10.0IL2RB
42inflammatory bowel disease10.0MPO
43hepatitis b10.0TNFRSF8
44myocardial infarction10.0MME
45osteosarcoma10.0TNFRSF8
46cystadenoma10.0MME
47pancreatitis10.0MPO
48giant cell tumor10.0ACPP
49leiomyoma10.0MME
50acute pancreatitis10.0MPO

Graphical network of the top 20 diseases related to Intravascular Large B-Cell Lymphoma:



Diseases related to intravascular large b-cell lymphoma

Clinical Features for Intravascular Large B-Cell Lymphoma

Drugs & Therapeutics for Intravascular Large B-Cell Lymphoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Intravascular Large B-Cell Lymphoma

Drug clinical trials:

Search ClinicalTrials for Intravascular Large B-Cell Lymphoma

Search NIH Clinical Center for Intravascular Large B-Cell Lymphoma

Search CenterWatch for Intravascular Large B-Cell Lymphoma

Genetic Tests for Intravascular Large B-Cell Lymphoma

Anatomical Context for Intravascular Large B-Cell Lymphoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Intravascular Large B-Cell Lymphoma:

33
Bone marrow, Spleen, Brain, Liver, Lung, Breast, Skin, Uterus, Prostate, Nk cells, T cells, B cells

Animal Models for Intravascular Large B-Cell Lymphoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Intravascular Large B-Cell Lymphoma

Sources:
51PubMed
See all sources

Articles related to Intravascular Large B-Cell Lymphoma:

(show all 41)
idTitleAuthorsYear
1
Potential utility of serum soluble LR11 as a diagnostic biomarker for intravascular large B-cell lymphoma. (24401112)
2014
2
Intravascular large B-cell lymphoma confirmed by brain biopsy: a case report. (23420723)
2013
3
Liver dysfunction and thrombocytopenia diagnosed as intravascular large B-cell lymphoma using a timely and accurate transjugular liver biopsy. (23994980)
2013
4
Management of an unusual case of intravascular large B-cell lymphoma of the penis, prostate, and bones with CNS relapse. (23650410)
2013
5
Asian-type intravascular large B-cell lymphoma of the spleen and bone marrow with Hodgkin-like morphology and immunophenotype. (23961992)
2013
6
Indication for random skin biopsy for the diagnosis of intravascular large B cell lymphoma. (22414723)
2012
7
PET-negative pulmonary intravascular large B cell lymphoma diagnosed by a random transbronchial lung biopsy. (21909695)
2012
8
Generalized telangiectasia as the manifestation of intravascular large B-cell lymphoma complicated with breast cancer. (22735172)
2012
9
Random skin biopsy of intravascular large B-cell lymphoma: a case report. (23032248)
2012
10
Peripheral bone involvement of intravascular large B-cell lymphoma on 99mTc-MDP bone scan and 18F-FDG PET/CT. (22785520)
2012
11
A fatal case of hemoperitoneum after ultrasound-guided liver biopsy in a patient with intravascular large B-cell lymphoma. (21377915)
2011
12
Random skin biopsy and bone marrow biopsy for diagnosis of intravascular large B cell lymphoma. (20957365)
2011
13
Intravascular large B-cell lymphoma diagnosed by FDG-PET/CT and endometrial biopsy. (22185801)
2011
14
A blind skin biopsy diagnosing an intravascular large B-cell lymphoma. (21233067)
2011
15
Intravascular large B-cell lymphoma cells in the bone marrow smear preparation. (21105866)
2011
16
Disseminated intravascular large-cell lymphoma with initial presentation mimicking Guillain-BarrAc syndrome. (20544922)
2010
17
Involvement of bone marrow with intravascular large B-cell lymphoma. (20231812)
2010
18
Intravascular large B-cell lymphoma involving mainly the uterus: report of a case using liquid-based cytology of the endometrium. (21053541)
2010
19
A case of intravascular large B-cell lymphoma (IVLBCL) with no abnormal findings on chest computed tomography diagnosed by random transbronchial lung biopsy. (21173545)
2010
20
Gallium scan-prompted skin biopsy revealed intravascular large B-cell lymphoma in a patient who presented with fever of unknown origin. (19387217)
2009
21
Intravascular ALK-positive anaplastic large-cell lymphoma mimicking inflammatory breast carcinoma. (19364961)
2009
22
Intravascular large B-cell lymphoma: successful therapy with bendamustine and rituximab. (19688165)
2009
23
Renal intravascular large B-cell lymphoma with early diagnosis by renal biopsy: a case report and review of the literature. (19036442)
2009
24
Intravascular large B cell lymphoma with neurological symptoms diagnosed on the basis of a senile angioma-like eruption. (21686374)
2009
25
The addition of rituximab to anthracycline-based chemotherapy significantly improves outcome in 'Western' patients with intravascular large B-cell lymphoma. (18699850)
2008
26
Intravascular large T-cell or NK-cell lymphoma: a rare variant of intravascular large cell lymphoma with frequent cytotoxic phenotype and association with Epstein-Barr virus infection. (18425045)
2008
27
Asian variant of intravascular large B-cell lymphoma diagnosed by bone marrow biopsy]. (17313078)
2007
28
Use of random skin biopsy for diagnosis of intravascular large B-cell lymphoma. (18053461)
2007
29
Intravascular large B-cell lymphoma associated with a near-tetraploid karyotype, rearrangement of BCL6, and a t(11;14)(q13;q32). (17116487)
2006
30
Intravascular large B-cell lymphoma following a relapsing stroke with temporary fever: a brain biopsy case. (16778343)
2006
31
Intravascular large B-Cell lymphoma with bone marrow involvement and superior sagittal sinus thrombosis: report of a case successfully treated with a CHOP/rituximab combination regimen. (15989707)
2005
32
Intravascular large B-cell lymphoma of the breast. (15695087)
2005
33
CD5+ Epstein-Barr virus-positive intravascular large B-cell lymphoma in the uterus co-existing with huge myoma. (15726593)
2005
34
Primary bilateral adrenal intravascular large B-cell lymphoma associated with adrenal failure. (12879956)
2003
35
Intravascular large B cell lymphoma diagnosed by senile angioma biopsy. (12583632)
2003
36
Prevalence of intravascular large B-cell lymphoma with bone marrow involvement at initial presentation. (12627851)
2003
37
Uncommon presentations of non-Hodgkin's lymphoma: case 1. Intravascular large B-cell lymphoma: diagnosis on prostate biopsy. (12560450)
2003
38
Intravascular large B-cell lymphoma or intravascular lymphomatosis: report of a case diagnosed by testicle biopsy. (11446739)
2001
39
A case of intravascular large B-cell lymphoma mimicking erythema nodosum: the importance of multiple skin biopsies. (10955689)
2000
40
Intravascular large B-cell lymphoma with bone marrow involvement at presentation and haemophagocytic syndrome: two Western cases in favour of a specific variant. (11122432)
2000
41
Intravascular large B-cell lymphoma. A report of five cases initially diagnosed by bone marrow biopsy. (10439806)
1999

Genetic Variations for Intravascular Large B-Cell Lymphoma

Expression for genes affiliated with Intravascular Large B-Cell Lymphoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Intravascular Large B-Cell Lymphoma

Search GEO for disease gene expression data for Intravascular Large B-Cell Lymphoma.

Pathways for genes affiliated with Intravascular Large B-Cell Lymphoma

Sources:
53R&D Systems, 38NCBI BioSystems Database, 12EMD Millipore, 30KEGG, 52QIAGEN, 56SinoBiological, 4Cell Signaling Technology
See all sources

Pathways related to Intravascular Large B-Cell Lymphoma according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.9IL2RB, IL2RA
29.7BCL2, BCL6, CD5
39.6BCL2, IL2RB, IL2RA
4
Hide members
9.6BCL2, IL2RB, IL2RA
5
Hide members
9.6BCL2, IL2RB, IL2RA
6
Hide members
9.5BCL2, BCL6, CCND1
79.5CCND1, BCL6, BCL2
89.5MME, IL2RA, CD5
99.4CCND1, IL2RA, IL2RB
10
Hide members
9.4IL2RB, IL2RA, CCND1
119.4CCND1, MPO, BCL2
12
Hide members
9.4IL2RB, IL2RA, B2M
139.4B2M, IL2RA, IL2RB
149.2CCND1, IL2RA, IL2RB, BCL2
15
Hide members
9.2CCND1, IL2RA, IL2RB, BCL2
169.0MPO, IL2RB, KMT2A, BCL6
17
Hide members
8.9BCL2, B2M, TNFRSF8
18
Hide members
8.5TNFRSF8, CXCR3, IL2RA, BCL2
198.4BCL6, MME, IL2RB, IL2RA, MPO, B2M
20
Hide members
8.2TNFRSF8, CXCR3, IL2RA, IL2RB, BCL2
21
Hide members
7.8CCND1, TNFRSF8, CXCR3, IL2RA, IL2RB, BCL2
22
Hide members
7.8CCND1, TNFRSF8, CXCR3, IL2RA, IL2RB, BCL2

Compounds for genes affiliated with Intravascular Large B-Cell Lymphoma

Sources:
45Novoseek, 50PharmGKB, 2BitterDB, 11DrugBank, 29IUPHAR, 24HMDB, 60Tocris Bioscience
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Compounds related to Intravascular Large B-Cell Lymphoma according to GeneCards/GeneDecks:

(show top 50)    (show all 87)
idCompoundScoreTop Affiliating Genes
1erythromycin45 50 2 1113.2IL2RA
2cycloheximide4510.2MME, IL2RB
3mycophenolate4510.2IL2RA, IL2RB
4lentinan4510.2IL2RA, IL2RB
5thymoglobulin4510.0IL2RA, IL2RB
6ginsenoside459.9BCL2, MME, CCND1
7cuprophan459.8B2M, IL2RA, IL2RB
8polysulfone459.8IL2RB, IL2RA, B2M
92-chlorodeoxyadenosine459.7B2M, IL2RA, BCL2
102,5-oligoadenylate459.7B2M, IL2RA, IL2RB
11methacholine45 1110.6MME, IL2RB, MPO
12methimazole45 2 1111.6B2M, MPO, IL2RA
13rituximab45 50 1111.6B2M, IL2RA, BCL6, BCL2
14il 10459.5CXCR3, IL2RA, IL2RB
15estrogen459.5BCL6, ACPP, KMT2A
16pentoxifylline45 1110.5IL2RB, IL2RA, MPO
17infliximab45 50 1111.5IL2RB, IL2RA, CXCR3
18ricin459.5TNFRSF8, CD5, IL2RB
19adriamycin459.4BCL2, MME, B2M, CCND1
20prednisolone45 29 1111.3MPO, IL2RA, IL2RB, KMT2A
21formaldehyde45 2410.2CCND1, B2M, MPO, IL2RA
22ifn-alpha459.2CXCR3, IL2RA, IL2RB
23chloride459.2MME, IL2RB, MPO, B2M
24tacrolimus45 50 1111.2IL2RB, IL2RA, CXCR3, CCND1
25n acetylcysteine459.2CCND1, MPO, IL2RA, IL2RB, BCL2
26neopterin459.2ACPP, IL2RB, IL2RA, B2M
27creatinine459.1CXCR3, IL2RB, MME, ACPP
28ricin a459.0IL2RA, TNFRSF8
29histamine45 29 2411.0MPO, CXCR3, IL2RA, IL2RB, MME
30cyclophosphamide45 50 1110.9B2M, MPO, IL2RA, IL2RB, BCL6, BCL2
31aspartate458.8B2M, IL2RB, KMT2A, ACPP
32vincristine45 50 1110.7CCND1, B2M, IL2RA, KMT2A, BCL6, BCL2
33phosphatidylinositol458.6CCND1, CXCR3, IL2RA, IL2RB, MME, BCL2
34genistein45 29 60 2 11 2413.6CCND1, B2M, IL2RA, IL2RB, KMT2A, BCL2
35cyclosporin a45 29 6010.5MME, IL2RB, IL2RA, B2M, TNFRSF8
36lactate458.5B2M, MPO, IL2RB, MME, ACPP, BCL6
37progesterone45 60 29 11 2412.4CCND1, CXCR3, IL2RB, MME, ACPP, BCL2
38doxorubicin45 50 1110.3CCND1, B2M, IL2RA, MME, KMT2A, BCL6
39testosterone45 60 11 2411.3ACPP, MME, IL2RA, B2M, CCND1
40arginine458.2CXCR3, IL2RA, IL2RB, MME, KMT2A, ACPP
41cisplatin45 50 60 1111.2CCND1, B2M, MPO, IL2RA, IL2RB, ACPP
42retinoic acid45 249.0CCND1, B2M, MPO, IL2RB, MME, KMT2A
43steroid457.9CCND1, B2M, CXCR3, IL2RA, IL2RB, MME
44serine457.7CCND1, B2M, MPO, CXCR3, IL2RB, KMT2A
45zinc45 248.7TNFRSF8, IL2RA, IL2RB, MME, KMT2A, ACPP
46vegf457.3CCND1, B2M, MPO, CXCR3, IL2RA, IL2RB
47thymidine45 248.1CCND1, TNFRSF8, B2M, CXCR3, IL2RA, IL2RB
48calcium45 50 11 2410.0TNFRSF8, B2M, MPO, CD5, CXCR3, IL2RB
49paraffin456.8BCL2, CCND1, TNFRSF8, B2M, MPO, CD5
50tyrosine456.5CCND1, TNFRSF8, CD5, CXCR3, IL2RA, IL2RB

GO Terms for genes affiliated with Intravascular Large B-Cell Lymphoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Intravascular Large B-Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.3B2M, CD5, CXCR3, IL2RA, IL2RB
2plasma membraneGO:0058866.8TNFRSF8, B2M, CD5, CXCR3, IL2RA, IL2RB

Biological processes related to Intravascular Large B-Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to DNA damage stimulusGO:0069749.5BCL2, BCL6, CCND1
2response to iron ionGO:0100399.5BCL2, CCND1

Molecular functions related to Intravascular Large B-Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-2 receptor activityGO:0049119.8IL2RB, IL2RA
2interleukin-2 bindingGO:0199769.6IL2RB, IL2RA
3identical protein bindingGO:0428028.6BCL2, ACPP, KMT2A, B2M

Products for genes affiliated with Intravascular Large B-Cell Lymphoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Intravascular Large B-Cell Lymphoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet