MCID: INT221
MIFTS: 46

Intravascular Large B-Cell Lymphoma malady

Blood diseases, Cancer diseases, Rare diseases, Immune diseases categories

Aliases & Classifications for Intravascular Large B-Cell Lymphoma

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Sources:
48Orphanet, 61UMLS, 26ICD10 via Orphanet
See all sources

Aliases & Descriptions for Intravascular Large B-Cell Lymphoma:

Name: Intravascular Large B-Cell Lymphoma 48
Angioendotheliomatosis Proliferans Systemisata 48
Malignant Angioendotheliomatosis 48
Angiotropic Large Cell Lymphoma 48
 
Intravascular Lymphomatosis 48
Tappeiner-Pfleger Disease 48
Angioendotheliomatosis 61


Classifications:



External Ids:

Orphanet48 98839
ICD10 via Orphanet26 C83.3

Summaries for Intravascular Large B-Cell Lymphoma

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MalaCards based summary: Intravascular Large B-Cell Lymphoma, also known as angioendotheliomatosis proliferans systemisata, is related to pancytopenia and b-cell lymphomas. An important gene associated with Intravascular Large B-Cell Lymphoma is BCL6 (B-cell CLL/lymphoma 6), and among its related pathways are Inflammatory Response Pathway and B Cell Receptor Signaling Pathway. The compounds lentinan and mycophenolate have been mentioned in the context of this disorder. Affiliated tissues include b cells, bone and lung, and related mouse phenotypes are tumorigenesis and liver/biliary system.

Related Diseases for Intravascular Large B-Cell Lymphoma

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Diseases related to Intravascular Large B-Cell Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 144)
idRelated DiseaseScoreTop Affiliating Genes
1pancytopenia31.2IL2RA, KMT2A
2b-cell lymphomas30.7CCND1, ACPP, BCL6, BCL2, CD5, CXCR3
3breast cancer30.7CCND1, BCL2
4systemic lupus erythematosus30.6MPO, CXCR3, IL2RA, IL2RB
5plasmacytoma30.4B2M, TNFRSF8, BCL6
6anaplastic large cell lymphoma30.1TNFRSF8, CXCR3, IL2RA, IL2RB, BCL6
7hodgkin lymphoma29.8TNFRSF8, KMT2A, IL2RA, IL2RB, BCL6, BCL2
8prostatitis10.8
9cerebritis10.7
10hemangioma10.6
11diffuse large b-cell lymphoma10.6
12senile angioma10.6
13cholecystitis10.6
14hepatitis10.5
15thrombocytopenia10.5
16dementia10.5
17hypopituitarism10.5
18interstitial lung disease10.5
19meningitis10.5
20panniculitis10.5
21proteinuria10.5
22malaria10.4IL2RB
23oral candidiasis10.4B2M
24uveitis10.4IL2RA, CXCR3
25intermediate uveitis10.4IL2RA, CXCR3
26posterior uveitis10.4IL2RB, IL2RA
27lymphomatoid papulosis10.4CXCR3, TNFRSF8
28benign breast phyllodes tumor10.4MME, ACPP
29malignant histiocytosis10.3
30histiocytosis10.3
31pfeiffer syndrome10.3TNFRSF8, IL2RB
32aspergillosis10.3
33hemolytic anemia10.3
34myoma10.3
35splenic infarction10.3
36hypercalcemia10.3
37cauda equina syndrome10.3
38choroiditis10.3
39sagittal sinus thrombosis10.3
40colitis10.3
41ischemia10.3
42lupus erythematosus10.3
43mononeuropathy10.3
44myopathy10.3
45thyroiditis10.3
46ring chromosome 1110.3
47syndrome of inappropriate antidiuretic hormone10.3
48aneurysm10.3
49blindness10.3
50alk-positive anaplastic large cell lymphoma10.3

Graphical network of the top 20 diseases related to Intravascular Large B-Cell Lymphoma:



Diseases related to intravascular large b-cell lymphoma

Symptoms for Intravascular Large B-Cell Lymphoma

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Drugs & Therapeutics for Intravascular Large B-Cell Lymphoma

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Drug clinical trials:

Search ClinicalTrials for Intravascular Large B-Cell Lymphoma

Search NIH Clinical Center for Intravascular Large B-Cell Lymphoma

Genetic Tests for Intravascular Large B-Cell Lymphoma

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Anatomical Context for Intravascular Large B-Cell Lymphoma

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MalaCards organs/tissues related to Intravascular Large B-Cell Lymphoma:

31
B cells, Bone, Lung, Skin, Bone marrow, Prostate, Uterus, Liver, Breast, Brain, Colon, Kidney, Spleen, Thyroid

Animal Models for Intravascular Large B-Cell Lymphoma or affiliated genes

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MGI Mouse Phenotypes related to Intravascular Large B-Cell Lymphoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020067.9BCL2, CCND1, CXCR3, KMT2A, B2M
2MP:00053707.8KMT2A, MME, IL2RB, BCL6, B2M
3MP:00053897.5IL2RB, BCL6, CCND1, KMT2A, B2M, BCL2
4MP:00107717.4CCND1, BCL2, MME, KMT2A, B2M, ACPP
5MP:00053857.3CXCR3, MPO, KMT2A, CCND1, BCL6, BCL2
6MP:00053787.3CCND1, B2M, IL2RA, IL2RB, BCL6, BCL2
7MP:00053766.9CCND1, BCL2, CXCR3, MME, KMT2A, MPO
8MP:00107686.6BCL2, BCL6, IL2RB, CCND1, CXCR3, KMT2A
9MP:00053975.9BCL2, B2M, TNFRSF8, MPO, KMT2A, CXCR3
10MP:00053875.5CCND1, BCL6, IL2RB, IL2RA, B2M, TNFRSF8

Publications for Intravascular Large B-Cell Lymphoma

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Articles related to Intravascular Large B-Cell Lymphoma:

(show top 50)    (show all 196)
idTitleAuthorsYear
1
Antemortem diagnosis with multiple random skin biopsies and transbronchial lung biopsy in a patient with intravascular large B-cell lymphoma, the so-called Asian variant lymphoma. (24632902)
2014
2
Synchronous invasive ductal carcinoma and intravascular large B-cell lymphoma of the breast: a case report and review of the literature. (24708809)
2014
3
Tandem triplication of the BCL2 gene in CD5-positive intravascular large B cell lymphoma with bone marrow involvement. (24577512)
2014
4
Simultaneous thrombosis of the mesenteric artery and vein as a novel clinical manifestation of intravascular large B-cell lymphoma. (24525901)
2014
5
Benefits of skin biopsy of senile hemangioma in intravascular large B-cell lymphoma: A case report and review of the literature. (24932279)
2014
6
Intravascular large B-cell lymphoma presenting as cauda equina syndrome and showing aberrant cytokeratin expression: a diagnostic challenge. (24614706)
2014
7
Intravascular large B-cell lymphoma confirmed by brain biopsy: a case report. (23420723)
2013
8
Intravascular large B-cell lymphoma presenting with anasarca-type edema and acute renal failure. (23885711)
2013
9
Liver dysfunction and thrombocytopenia diagnosed as intravascular large B-cell lymphoma using a timely and accurate transjugular liver biopsy. (23994980)
2013
10
Intravascular large B-cell lymphoma presenting as acute hemorrhagic cerebral infarct with delirium. (23884226)
2013
11
Mild proteinuria in a patient with glomerularlimited intravascular large B-cell lymphoma. (22541680)
2013
12
Generalized telangiectasia revealing intravascular large B-cell lymphoma. (23406023)
2013
13
Intravascular large B cell lymphoma presenting as cholecystitis: diagnostic challenges persist. (24288109)
2013
14
SIADH and partial hypopituitarism in a patient with intravascular large B-cell lymphoma: a rare cause of a common presentation. (23362070)
2013
15
Intravascular large B-cell lymphoma with hemophagocytic syndrome (Asian variant) in a Caucasian patient. (22808298)
2012
16
Indication for random skin biopsy for the diagnosis of intravascular large B cell lymphoma. (22414723)
2012
17
A fatal case of hemoperitoneum after ultrasound-guided liver biopsy in a patient with intravascular large B-cell lymphoma. (21377915)
2011
18
Progressive multifocal cerebral infarction from intravascular large B cell lymphoma presenting in a man: a case report. (21251318)
2011
19
Haemophagocytosis-related intravascular large B-cell lymphoma associated with skin eruption. (21279301)
2011
20
Intravascular large B-cell lymphoma of the uterus: a case with favorable clinical outcome. (19948641)
2011
21
Frequency of intravascular large B-cell lymphoma in Japan: study of the Osaka Lymphoma Study Group. (21481222)
2011
22
18F-FDG PET/CT in a case of intravascular large B-cell lymphoma. (20607536)
2010
23
Intravascular large B-cell lymphoma, an exclusively small vessel disease? A case report and review of literature. (20542564)
2010
24
Central nervous system involvement in intravascular large B-cell lymphoma: a retrospective analysis of 109 patients. (20412122)
2010
25
Neurolymphomatosis involving the trigeminal nerve and deep peroneal nerve in a patient with relapsed intravascular large B-cell lymphoma. (20528901)
2010
26
Fluorodeoxyglucose-PET/CT for diagnosis of intravascular large B-cell lymphoma. (20675506)
2010
27
Intravascular large B cell lymphoma: an elusive cause of pyrexia of unknown origin diagnosed postmortem. (20868278)
2010
28
Intravascular large B-cell lymphoma within a subcutaneous cavernous haemangioma. (20735401)
2010
29
Intravascular large B-cell lymphoma of the skin: typical clinical manifestations and a favourable response to rituximab-containing therapy. (19590171)
2009
30
Intravascular large B cell lymphoma: proposed of the strategy for early diagnosis and treatment of patients with rapid deteriorating condition. (19363707)
2009
31
Gallium scan-prompted skin biopsy revealed intravascular large B-cell lymphoma in a patient who presented with fever of unknown origin. (19387217)
2009
32
Intravascular large B cell lymphoma: when lymphoma is suspected but routine diagnostic work-up is negative. (19883320)
2009
33
Intravascular large B-cell lymphoma: remission after rituximab-cyclophosphamide, doxorubicin, vincristine, and prednisolone chemotherapy. (19632742)
2009
34
Intravascular large B-cell lymphoma presenting in subcutaneous fat tissue and simulating panniculitis clinically. (20415677)
2009
35
Analysis of CXCL9 and CXCR3 expression in a case of intravascular large B-cell lymphoma. (19766346)
2009
36
The addition of rituximab to anthracycline-based chemotherapy significantly improves outcome in 'Western' patients with intravascular large B-cell lymphoma. (18699850)
2008
37
Sustained remission after rituximab-containing chemotherapy for intravascular large B-cell lymphoma. (18434690)
2008
38
Definition, diagnosis, and management of intravascular large B-cell lymphoma: proposals and perspectives from an international consensus meeting. (17577023)
2007
39
Intravascular large B-cell lymphoma presenting as cerebellar and cerebral infarction. (17502477)
2007
40
Asian variant of intravascular large B-cell lymphoma diagnosed by bone marrow biopsy]. (17313078)
2007
41
Intravascular large B-cell lymphoma of the uterus presenting as fever of unknown origin (FUO) and revealed by FDG-PET. (17672184)
2007
42
Intravascular large B-cell lymphoma with multisystem involvement. (16966288)
2006
43
Intravascular large B-cell lymphoma associated with a near-tetraploid karyotype, rearrangement of BCL6, and a t(11;14)(q13;q32). (17116487)
2006
44
Primary bilateral adrenal intravascular large B-cell lymphoma associated with adrenal failure. (12879956)
2003
45
A case of intravascular large B-cell lymphoma with multiple organ involvement. (14739519)
2003
46
Intravascular large B-cell lymphoma presenting as cutaneous panniculitis. (14677722)
2003
47
Intravascular large B-cell lymphoma with a fulminant clinical course: a case report with definite diagnosis post mortem. (12196378)
2002
48
Myeloperoxidase-positive intravascular large B-cell lymphoma. (11419984)
2001
49
Unusual sites of involvement by hematologic malignancies. Case 1. Intravascular large B-cell lymphoma presenting with CNS symptoms. (11579120)
2001
50
Primary cutaneous large B-cell lymphoma of the leg relapsing as cutaneous intravascular large B-cell lymphoma. (11735727)
2001

Variations for Intravascular Large B-Cell Lymphoma

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Expression for genes affiliated with Intravascular Large B-Cell Lymphoma

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Search GEO for disease gene expression data for Intravascular Large B-Cell Lymphoma.

Pathways for genes affiliated with Intravascular Large B-Cell Lymphoma

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Pathways related to Intravascular Large B-Cell Lymphoma according to GeneCards Suite gene sharing:

(show all 25)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8IL2RA, IL2RB
29.7CD5, BCL2, BCL6
3
Show member pathways
9.5IL2RB, IL2RA, BCL2
4
Show member pathways
IL-2 Signaling pathway36
9.5BCL2, IL2RB, IL2RA
5
Show member pathways
Immune response IL 22 signaling pathway59
G protein signaling N RAS regulation pathway59
9.5BCL2, IL2RB, IL2RA
6
Show member pathways
IL2 signaling events mediated by STAT536
9.5IL2RA, BCL2, IL2RB
79.4CD5, IL2RA, MME
8
Show member pathways
DNA damage response (only ATM dependent)36
Wnt Signaling Pathway and Pluripotency36
9.3BCL6, BCL2, CCND1
99.3BCL2, BCL6, CCND1
10
Show member pathways
Ras signaling in the CD4+ TCR pathway36
9.2IL2RB, IL2RA, B2M
11
Show member pathways
Immune response IL 12 induced IFN gamma production59
9.2IL2RA, B2M, IL2RB
12
Show member pathways
9.2TNFRSF8, BCL2, B2M
13
Show member pathways
Type III interferon signaling36
9.1IL2RB, IL2RA, CCND1
14
Show member pathways
IL-9 Signaling Pathway36
Development Thrombopoietin regulated cell processes59
IL-7 Signaling Pathway36
Immune response IL 9 signaling pathway59
9.1CCND1, IL2RA, IL2RB
159.1CCND1, IL2RB, IL2RA
169.1MPO, CCND1, BCL2
17
Show member pathways
9.0CCND1, B2M, IL2RA
188.9BCL2, CCND1, IL2RA, IL2RB
19
Show member pathways
8.9CCND1, IL2RB, IL2RA, BCL2
20
Show member pathways
8.6IL2RB, TNFRSF8, BCL2, CXCR3, IL2RA
21
Show member pathways
8.6CXCR3, TNFRSF8, IL2RA, IL2RB, BCL2
228.6BCL6, KMT2A, MPO, IL2RB
238.1MME, MPO, B2M, IL2RA, IL2RB, BCL6
24
Show member pathways
8.0TNFRSF8, CXCR3, CCND1, IL2RA, BCL2, IL2RB
25
Show member pathways
8.0IL2RA, CCND1, CXCR3, IL2RB, TNFRSF8, BCL2

Compounds for genes affiliated with Intravascular Large B-Cell Lymphoma

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Compounds related to Intravascular Large B-Cell Lymphoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 121)
idCompoundScoreTop Affiliating Genes
1lentinan4410.1IL2RA, IL2RB
2mycophenolate4410.0IL2RB, IL2RA
3ricin449.7IL2RB, CD5, TNFRSF8
4il 10449.6IL2RA, IL2RB, CXCR3
52-chlorodeoxyadenosine449.6IL2RA, BCL2, B2M
6cuprophan449.6IL2RB, B2M, IL2RA
7ginsenoside449.6MME, CCND1, BCL2
8polysulfone449.6IL2RB, IL2RA, B2M
9infliximab44 50 1111.5IL2RB, CXCR3, IL2RA
102,5-oligoadenylate449.5B2M, IL2RA, IL2RB
11rituximab44 50 1111.5IL2RA, BCL2, B2M, BCL6
12ifn-alpha449.4CXCR3, IL2RB, IL2RA
13methacholine44 50 1111.4MME, IL2RB, MPO
14methimazole44 1 1111.4IL2RA, B2M, MPO
15neopterin449.3ACPP, B2M, IL2RA, IL2RB
16erythromycin44 1 50 1112.3IL2RA, MPO, IL2RB
17pentoxifylline44 1110.2MPO, IL2RB, IL2RA
18tacrolimus44 50 1111.1CCND1, IL2RB, IL2RA, CXCR3
19adriamycin449.0CCND1, B2M, MME, BCL2
20chloride448.9MME, B2M, IL2RB, MPO
21histamine44 28 2410.9CXCR3, MME, MPO, IL2RA, IL2RB
22prednisolone44 28 1110.8MPO, IL2RB, IL2RA, KMT2A
23formaldehyde44 249.8B2M, MPO, CCND1, IL2RA
24n acetylcysteine448.8IL2RB, BCL2, CCND1, MPO, IL2RA
25cyclophosphamide44 50 1110.7IL2RA, IL2RB, B2M, BCL2, BCL6, MPO
26cyclosporin a44 28 6010.6MME, IL2RA, B2M, IL2RB, TNFRSF8
27progesterone44 28 60 24 1112.6MME, CCND1, BCL2, IL2RB, ACPP, CXCR3
28lactate448.6IL2RB, MME, ACPP, MPO, B2M, BCL6
29phosphatidylinositol448.5MME, CXCR3, CCND1, IL2RA, IL2RB, BCL2
30pge2448.5IL2RB, IL2RA, MME, MPO, B2M, CXCR3
31cycloheximide448.5IL2RB, B2M, BCL6, MME, CCND1, BCL2
32indomethacin44 28 60 1111.4B2M, IL2RA, MPO, MME
33aspartate448.4KMT2A, IL2RA, IL2RB, ACPP, B2M
34testosterone44 60 24 1111.3MME, CCND1, ACPP, B2M, IL2RA
35arginine448.3CXCR3, ACPP, IL2RA, IL2RB, MME, KMT2A
36creatinine448.2B2M, MME, CXCR3, ACPP, IL2RB, MPO
37vincristine44 50 1110.1KMT2A, IL2RA, BCL6, B2M, BCL2, CCND1
38cisplatin44 50 60 1111.0IL2RB, IL2RA, ACPP, MPO, BCL2, CCND1
39steroid448.0CXCR3, CCND1, ACPP, IL2RA, IL2RB, MME
40genistein44 28 60 1 24 1112.9IL2RB, B2M, BCL2, KMT2A, CCND1, IL2RA
41zinc44 248.9MME, TNFRSF8, BCL6, KMT2A, IL2RB, IL2RA
42calcium44 50 24 1110.7CXCR3, IL2RB, CD5, MME, ACPP, B2M
43doxorubicin44 50 119.6B2M, KMT2A, MME, CCND1, IL2RA, BCL2
44thymidine44 248.5B2M, MME, TNFRSF8, IL2RB, IL2RA, ACPP
45vegf447.3ACPP, BCL2, B2M, MPO, MME, CXCR3
46retinoic acid44 248.2BCL6, B2M, MPO, KMT2A, MME, BCL2
47estrogen447.0B2M, BCL2, IL2RA, BCL6, ACPP, CCND1
48paraffin446.9BCL6, ACPP, CD5, BCL2, IL2RA, B2M
49tyrosine446.7MME, KMT2A, CD5, CXCR3, BCL6, ACPP
50serine446.1MPO, KMT2A, CXCR3, CCND1, ACPP, IL2RB

GO Terms for genes affiliated with Intravascular Large B-Cell Lymphoma

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Cellular components related to Intravascular Large B-Cell Lymphoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098978.5CD5, IL2RB, IL2RA, CXCR3, B2M
2extracellular vesicular exosomeGO:00700628.3ACPP, MME, MPO, TNFRSF8, B2M
3plasma membraneGO:00058867.1B2M, TNFRSF8, MME, CXCR3, ACPP, IL2RA

Biological processes related to Intravascular Large B-Cell Lymphoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of B cell proliferationGO:003089010.0BCL2, BCL6
2response to iron ionGO:00100399.7BCL2, CCND1
3T cell differentiation in thymusGO:00330779.4BCL2, B2M
4cellular response to DNA damage stimulusGO:00069749.3BCL2, BCL6, CCND1
5apoptotic processGO:00069158.6KMT2A, CXCR3, IL2RA, BCL2

Molecular functions related to Intravascular Large B-Cell Lymphoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1interleukin-2 receptor activityGO:00049119.7IL2RB, IL2RA
2interleukin-2 bindingGO:00199769.5IL2RB, IL2RA
3identical protein bindingGO:00428028.6BCL2, ACPP, KMT2A, B2M

Sources for Intravascular Large B-Cell Lymphoma

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet