Aliases & Classifications for Intussusception

MalaCards integrated aliases for Intussusception:

Name: Intussusception 53 12 28 51 41 14
Invagination of Intestine or Colon 12
Intussusception of Intestine 12
Intussusception Nos 12

Characteristics:

OMIM:

53
Inheritance:
autosomal dominant


HPO:

31
intussusception:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 53 147710
Disease Ontology 12 DOID:8446
ICD10 32 K56.1
ICD9CM 34 560.0
MeSH 41 D007443
NCIt 46 C113484
MedGen 39 C0021933
SNOMED-CT via HPO 65 263681008
UMLS 69 C0021933

Summaries for Intussusception

MalaCards based summary : Intussusception, also known as invagination of intestine or colon, is related to gastroduodenitis and intestinal tuberculosis. An important gene associated with Intussusception is STK11 (Serine/Threonine Kinase 11), and among its related pathways/superpathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Vaccines and Citric Acid have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and appendix, and related phenotypes are cardiovascular system and hematopoietic system

Description from OMIM: 147710

Related Diseases for Intussusception

Diseases related to Intussusception via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 404)
# Related Disease Score Top Affiliating Genes
1 gastroduodenitis 30.5 CD40LG CD79A
2 intestinal tuberculosis 30.1 CD79A CRP
3 acalculous cholecystitis 30.1 CD40LG CRP
4 purpura 29.9 CD40LG CD79A CRP
5 typhoid fever 29.8 CFTR CRP IL6
6 cholangitis 29.6 CD40LG CFTR CRP IL6
7 bronchopneumonia 29.5 CD40LG CD79A
8 leptospirosis 29.5 CD40LG CRP IL6
9 jejunoileitis 29.5 CD40LG CD79A
10 coccidiosis 29.3 CD40LG CD79A
11 vasculitis 29.3 CD40LG CD79A CRP
12 acquired immunodeficiency syndrome 29.3 CD40LG CD79A IL6
13 myeloma, multiple 29.2 CD40LG CD79A IL6
14 systemic lupus erythematosus 28.0 CD40LG CD79A CRP ENG IL6
15 thoraco abdominal enteric duplication 11.0
16 cold agglutinin disease 10.5 CRP IL6
17 diabetic foot ulcers 10.5 CRP IL6
18 cryopyrin-associated periodic syndrome 10.5 CRP IL6
19 neutrophilia, hereditary 10.5 CRP IL6
20 acute cholangitis 10.5 CRP IL6
21 cardiogenic shock 10.5 CRP IL6
22 uremic pruritus 10.5 CRP IL6
23 spinal disease 10.5 CRP IL6
24 mononeuritis multiplex 10.5 CD40LG CRP
25 castleman disease 10.5 CRP IL6
26 angina pectoris 10.4 CRP IL6
27 viral pneumonia 10.4 CRP IL6
28 japanese spotted fever 10.4 CD40LG CRP
29 dressler's syndrome 10.4 CD40LG CRP
30 cecal disease 10.4 CRP IL6
31 relapsing polychondritis 10.4 CRP IL6
32 subacute thyroiditis 10.4 CRP IL6
33 louse-borne relapsing fever 10.4 CRP IL6
34 multicentric castleman disease 10.4 CRP IL6
35 transient arthritis 10.4 CD40LG IL6
36 mite infestation 10.3 CD79A CFTR
37 ischemic heart disease 10.3 CRP IL6
38 selective igg deficiency disease 10.3 CD40LG CD79A
39 c1q nephropathy 10.3 CD40LG CD79A
40 critical limb ischemia 10.3 IL6 TEK
41 meningovascular neurosyphilis 10.3 CD40LG CD79A
42 alpha chain disease 10.3 CD40LG CD79A
43 brill-zinsser disease 10.3 CD40LG CD79A
44 exudative glomerulonephritis 10.3 CD40LG CD79A
45 mesenteric lymphadenitis 10.3 CRP IL6
46 cork-handlers' disease 10.3 CD40LG CD79A
47 salpingo-oophoritis 10.3 CD40LG CD79A
48 early yaws 10.3 CD40LG CD79A
49 ventilation pneumonitis 10.3 CD40LG CD79A
50 chronic interstitial cystitis 10.3 CD40LG CD79A

Graphical network of the top 20 diseases related to Intussusception:



Diseases related to Intussusception

Symptoms & Phenotypes for Intussusception

Symptoms via clinical synopsis from OMIM:

53
GI:
intussusception


Clinical features from OMIM:

147710

Human phenotypes related to Intussusception:

31
# Description HPO Frequency HPO Source Accession
1 intussusception 31 HP:0002576

MGI Mouse Phenotypes related to Intussusception:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.92 AIF1 STK11 CD40LG TEK CRP ENG
2 hematopoietic system MP:0005397 9.91 STK11 CD40LG TEK CD79A CFTR ENG
3 homeostasis/metabolism MP:0005376 9.85 STK11 CD40LG TEK CD79A CFTR CRP
4 nervous system MP:0003631 9.56 AIF1 STK11 CD40LG TEK CD79A ENG
5 vision/eye MP:0005391 9.1 AIF1 STK11 TEK CFTR EPB41L5 IL6

Drugs & Therapeutics for Intussusception

Drugs for Intussusception (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 4,Phase 3,Phase 1,Phase 2
2
Citric Acid Approved, Nutraceutical, Vet_approved Phase 3 77-92-9 311
3 Pharmaceutical Solutions Phase 3
4 Citrate Nutraceutical Phase 3
5
Hydrocortisone Approved, Vet_approved 50-23-7 657311 5754
6
Butyric Acid Experimental, Investigational 107-92-6 264
7 Hemostatics
8 Anti-Bacterial Agents
9 Antibiotics, Antitubercular
10 Anti-Inflammatory Agents
11 Cortisol succinate
12 Hydrocortisone 17-butyrate 21-propionate
13 Hydrocortisone acetate
14 Hydrocortisone-17-butyrate

Interventional clinical trials:

(show all 33)

# Name Status NCT ID Phase Drugs
1 RCT: STARR vs Biofeedback Completed NCT00556283 Phase 4
2 Study of Stapled Transanal Rectal Resection (STARR) Surgery in Refractory Constipation Associated With Obstructive Defecation Syndrome (ODS) Completed NCT00256984 Phase 4
3 Stapled Trans Anal Rectal Resection (STARR) for Outlet Obstruction: Functional and Morphological Outcome Completed NCT00521872 Phase 4
4 Potential Mechanisms for Intussusception After Rotavirus Vaccine-Pilot Study Active, not recruiting NCT02542462 Phase 4 Rotarix®,;Rotarix®, with other routine vaccines;RotaTeq®,;RotaTeq®, with other routine vaccines
5 Optimising Rotavirus Vaccine in Aboriginal Children Not yet recruiting NCT02941107 Phase 4 Rotarix (RV1);Placebo
6 A Phase III Clinical Trial to Evaluate the Protective Efficacy of Three Doses of Oral Rotavirus Vaccine (ORV) 116E Unknown status NCT01305109 Phase 3
7 A Study to Test 2 Doses of GSK Biologicals' Oral Live Attenuated Human Rotavirus (HRV) Vaccine in Healthy Infants Completed NCT00197210 Phase 3
8 A Study to Test 2 Doses of the HRV Vaccine in Healthy Infants. Completed NCT00140673 Phase 3
9 Long-term Efficacy and Safety of Subjects Approximately 3 Years After Priming With 2 Doses of GSK Bio's HRV Vaccine. Completed NCT00420316 Phase 3
10 Rotavirus Efficacy and Safety Trial (REST)(V260-006) Completed NCT00090233 Phase 3
11 A Study of the Immunogenicity, Tolerability, and Safety of a New Formulation of RotaTeq™ in Infants (V260-035) Completed NCT01600092 Phase 3
12 Efficacy, Safety, and Immunogenicity of V260 in Healthy Chinese Infants (V260-024) Completed NCT02062385 Phase 3
13 Efficacy and Safety of a Pentavalent Rotavirus Vaccine (BRV-PV) Against Severe Rotavirus Gastroenteritis in Niger Active, not recruiting NCT02145000 Phase 3
14 Dose Escalation Study to Evaluate Oral Rotavirus Vaccine 116E Live Attenuated in Healthy Infants 8 to 20 Weeks Old Unknown status NCT00439660 Phase 1, Phase 2
15 Safety and Immunogenicity of Rotavirus Vaccine (RotaTeq(R)) in Infants With Short Bowel Syndrome Completed NCT00767364 Phase 1
16 Surgical Treatment of Obstructed Defecation Syndrome Unknown status NCT01899209
17 Evaluation of Universal Rotavirus Vaccination Program Unknown status NCT01273077
18 Study to Assess the Incidence of Intussusception in Children < 2 Years of Age in Singapore Completed NCT01177839
19 Intussusception Surveillance After Rotarix Introduction in Mexico Completed NCT00595205
20 Study on the Incidence of Intussusception (IS) in Children Aged < 12 Months in Japan Completed NCT01479491
21 Implementing Hospital-based Active Surveillance Procedures for Vaccine Safety Monitoring at IMSS Hospitals in Mexico Completed NCT00436358
22 Stapled TransAnal Rectal Resection (STARR) With Contour® TranstarTM Completed NCT00673400
23 Children's Surgery in Sub-Saharan Africa Completed NCT03185637
24 Special Drug Use Investigation for ROTARIX® Completed NCT01636739
25 Drug Use Investigation for ROTARIX® Completed NCT01636193
26 Long Term Results of STARR With Contour Transtar Completed NCT02971332
27 Safety Study of GSK Biologicals' Rotavirus Vaccine (Rotarix®) Administered to Children Aged <1 Year in the United States Completed NCT00875641
28 Obstructed Defaecation: Proctography Versus Ultrasound in Symptomatic Patients Completed NCT02239302
29 Gastric Plication in Mexican Patients Completed NCT03210207
30 Point-of-Care Ultrasonography for Intussusception Recruiting NCT03360643
31 Effect of Hydrocortisone on Improving Outcome of Pneumatic Reduction of Infantile Intussusception Recruiting NCT02691858 Hydrocortisone;Saline
32 Correlation of Anal Acoustic Reflectometry Parameters With Degree of Rectal Intussusception and Prolapse Recruiting NCT02774798
33 Does the Stapled Transanal Rectal Resection (STARR Procedure) Has an Effect on Anal Compliance ? Recruiting NCT02052063

Search NIH Clinical Center for Intussusception

Cochrane evidence based reviews: intussusception

Genetic Tests for Intussusception

Genetic tests related to Intussusception:

# Genetic test Affiliating Genes
1 Intussusception 28

Anatomical Context for Intussusception

MalaCards organs/tissues related to Intussusception:

38
Colon, Small Intestine, Appendix, Pancreas, Testes, Lung, B Cells

Publications for Intussusception

Articles related to Intussusception:

(show top 50) (show all 930)
# Title Authors Year
1
Appendiceal intussusception. ( 29316118 )
2018
2
Ileocecal intussusception extending to left colon due to endometriosis. ( 29364012 )
2018
3
Intussusception. ( 29278567 )
2018
4
Contribution of the virtual colonoscopy in a case of intestinal intussusception. ( 29313697 )
2018
5
Incidence and epidemiology of intussusception among children under 2a8^years of age in Chenzhou and Kaifeng, China, 2009-2013. ( 29439864 )
2018
6
Sonographic Evaluation and Monitoring of Pneumoperitoneum After Air Enema Reduction for Intussusception. ( 29438126 )
2018
7
Mantle Cell Lymphoma with a Single Protruding Lesion as the Cause of Intussusception. ( 29434133 )
2018
8
Comparison Between Small and Large Bowel Intussusception in Children: The Experience of a Large Tertiary Care Pediatric Hospital. ( 29337838 )
2018
9
Ileocecal endometriosis as an infrequent cause of intussusception. ( 29278003 )
2018
10
Fever as a Presenting Symptom in Children Evaluated for Ileocolic Intussusception: The Experience of a Large Tertiary Care Pediatric Hospital. ( 29337836 )
2018
11
Gastroduodenal intussusception and pylorus obstruction induced by a c-KIT-negative gastric gastrointestinal stromal tumor: case report and review of the literature. ( 29346826 )
2018
12
Idiopathic adult ileo-colonic intussusception. ( 29264001 )
2017
13
Protein-losing Enteropathy Caused by Spontaneous Reduction of Intussusception with Meckel's Diverticulum. ( 28413865 )
2017
14
Hospitalization rates for intussusception in children aged 0-59A months from 2009 to 2014 in Italy. ( 28075671 )
2017
15
Say What? Bannayan-Riley-Ruvalcaba Syndrome Presenting with Gastrointestinal Bleeding Due to Hamartoma-Induced Intussusception. ( 28168574 )
2017
16
A rare cause of recurrent acute pancreatitis: duodenum intussusception by a fenestrated duodenal web. ( 28342893 )
2017
17
Small Bowel Intussusception in a 16-Month-Old Child With Peutz-Jeghers Syndrome. ( 28929791 )
2017
18
Antegrade jejunogastric intussusception and common bile duct stones at 14 months after gastrectomy and cholecystectomy: A case report. ( 28846944 )
2017
19
Point-of-Care Ultrasound Could Streamline the Emergency Department Workflow of Clinically Nonspecific Intussusception. ( 28926507 )
2017
20
Burkitt lymphoma as a lead point for jejunojejunal intussusception in a human immunodeficiency virus patient. ( 28523628 )
2017
21
Epidemiological Correlation between Fecal Adenovirus Subgroups and Pediatric Intussusception in Korea. ( 28875609 )
2017
22
Unparalleled patterns of intussusception and rotavirus gastroenteritis hospitalization rates among children younger than six years in Italy. ( 28067936 )
2017
23
Effects of esketamine sedation compared to morphine analgesia on hydrostatic reduction of intussusception: A case-cohort comparison study. ( 28940868 )
2017
24
Intussusception due to an Inverted Meckel's Diverticulum Diagnosed by Double-Balloon Enteroscopy. ( 29282383 )
2017
25
Gastroduodenojejunal Intussusception: A Very Rare Complication of a Pedunculated Gastric Harmatomatous Giant Polyp. ( 28050044 )
2017
26
Rare diagnosis of intestinal lipomatosis complicated by intussusception in an adult: A case report. ( 28898799 )
2017
27
Unusual ultrasound appearance of small bowel intussusception and secondary bowel obstruction in a child with Peutz-Jeghers syndrome. ( 28314199 )
2017
28
Incidence of acute intussusception among infants in eastern France: results of the EPIstudy trial. ( 28058530 )
2017
29
Perforated Meckel's Diverticulum causing Intussusception in a Neonate. ( 28920033 )
2017
30
Intussusception in a preterm newborn. ( 28899633 )
2017
31
A Clinical Scoring System to Predict the Clinical Sequelae of Computed Tomography Diagnosed Intussusception. ( 28916884 )
2017
32
BRUNNER GLAND ADENOMA MASQUERADING AS DUODENAL GASTROINTESTINAL STROMAL TUMOR WITH INTUSSUSCEPTION: CASE REPORT. ( 28489176 )
2017
33
Intussusception caused by heterotopic gastric mucosa in small intestine: a case report. ( 28893301 )
2017
34
A case of small intestinal intussusception caused by anisakiasis diagnosed and treated by upper gastrointestinal endoscopy. ( 28781357 )
2017
35
Intussusception in Premature Baby: Unusual Cause of Bowel Obstruction and Perforation. ( 28083499 )
2017
36
Sporadic Jejunal Lateral Spreading Tumor: A Rare Cause of Recurrent Jejunojejunal Intussusception. ( 28848802 )
2017
37
The Role of Laparoscopy in the Management of a Diagnostic Dilemma: Jejunal Ectopic Pancreas Developing into Jejunojejunal Intussusception. ( 28819577 )
2017
38
Adult intussusception involving colonic lipoma: a case study. ( 29266686 )
2017
39
Triple site intussusceptions in Peutz-Jeghers syndrome. ( 28768368 )
2017
40
Epidemiology of childhood intussusception in Bangladesh: Findings from an active national hospital based surveillance system, 2012-2016. ( 28941622 )
2017
41
Transient Adult Jejunojejunal Intussusception: A Case of Conservative Management vs. Surgery. ( 29317946 )
2017
42
Follicular dendritic cell sarcoma presenting as colonic intussusception. ( 29256544 )
2017
43
A randomized trial of pneumatic reduction versus hydrostatic reduction for intussusception in pediatric patients. ( 28827051 )
2017
44
Submucosal Colonic Lipoblastoma Presenting With Colo-colonic Intussusception in an Infant. ( 28420321 )
2017
45
Rare cause of colonic intussusception in an adult. ( 28918406 )
2017
46
Antegrade jejunojejunal intussusception inside a retrograde jejunogastric intussusception (double intussusception)-A rare case report. ( 28881334 )
2017
47
An intestinal carcinoid causing transient jejunal intussusception in an adult-A case report. ( 28092782 )
2017
48
Incidentally Detected Small Intestine Intussusception Caused by Primary Small Intestine Carcinoma on (18)F-FDG PET/CT. ( 28878855 )
2017
49
Implementing ultrasound-guided hydrostatic reduction of intussusception in a low-resource country in Sub-Saharan Africa: our initial experience in Ethiopia. ( 28840373 )
2017
50
Subtle presentation of jejunal lipomata with intussusception in a young adult. ( 29423142 )
2017

Variations for Intussusception

Expression for Intussusception

Search GEO for disease gene expression data for Intussusception.

Pathways for Intussusception

Pathways related to Intussusception according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.2 CD79A ENG IL6
2 10.78 CD79A ENG IL6
3 10.43 CRP IL6

GO Terms for Intussusception

Cellular components related to Intussusception according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 8.92 CD40LG CFTR ENG TEK

Biological processes related to Intussusception according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.71 AIF1 CD40LG IL6 TEK
2 inflammatory response GO:0006954 9.46 AIF1 CD40LG CRP IL6
3 positive regulation of protein phosphorylation GO:0001934 9.43 AIF1 ENG TEK
4 sprouting angiogenesis GO:0002040 9.37 ENG TEK
5 positive regulation of focal adhesion assembly GO:0051894 9.32 EPB41L5 TEK
6 negative regulation of lipid storage GO:0010888 8.96 CRP IL6
7 positive regulation of T cell proliferation GO:0042102 8.8 AIF1 CD40LG IL6

Sources for Intussusception

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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