COLON
MCID: INT051
MIFTS: 58

Intussusception (COLON) malady

Gastrointestinal diseases category
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Summaries for Intussusception

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47OMIM, 33MalaCards
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MalaCards: Intussusception, also known as intussusception of intestine, is related to peutz-jeghers syndrome and intestinal obstruction. An important gene associated with Intussusception is STK11 (serine/threonine kinase 11), and among its related pathways are Presenilin action in Notch and Wnt signaling and Jak/Stat Pathway. The compounds refacto and kogenate have been mentioned in the context of this disorder. Affiliated tissues include colon, appendix and small intestine, and related mouse phenotypes are reproductive system and liver/biliary system.

Description from OMIM:47 147710

Aliases & Classifications for Intussusception

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Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 27ICD9CM, 58SNOMED-CT, 35MeSH, 47OMIM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

intussusception 8 10 45 62
intussusception of intestine 8
invagination of intestine 8
intussusception nos 8
colon 8


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Disease Ontology8 DOID:8446
ICD9CM27 560.0
MeSH35 D007443
OMIM47 147710
ICD1025 K56.1

Related Diseases for Intussusception

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17GeneCards, 18GeneDecks
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Diseases related to Intussusception via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 240)
idRelated DiseaseScoreTop Affiliating Genes
1peutz-jeghers syndrome31.1STK11, APC
2intestinal obstruction30.5CFTR, ALB
3gastroenteritis30.3ZNF185
4pancreatitis30.3CFTR, IL6, ALB, CRP
5cholangitis30.2CFTR, ALB
6acute pancreatitis30.2CRP, IL6, CFTR
7colon cancer30.2CFTR, APC, STK11, CCND1
8cystic fibrosis30.1CFTR, F8, ALB
9peritonitis30.1IL6, ALB, CRP
10crohn's disease30.0ALB, CRP
11kaposi's sarcoma30.0IL6, F8
12burkitt's lymphoma30.0WAS, CCND1, IL6, F8, ALB, CD40LG
13deficiency anemia29.9IL6, ALB, CRP
14multiple myeloma29.8CCND1, IL6
15familial adenomatous polyposis29.8APC, STK11, CCND1
16acquired immunodeficiency syndrome29.7IL6, F8, ALB
17systemic lupus erythematosus29.7IL6, F8, CRP, CD40LG
18colorectal cancer29.7APC, STK11, CCND1
19lung cancer29.7STK11, CCND1, ALB
20sepsis29.7IL6, ALB, CRP
21diarrhea29.7CRP, ALB, ZNF185, CFTR
22myeloma29.6CCND1, IL6, ALB, CD40LG
23leukemia29.6CD40LG, F8, IL6, CCND1, CFTR
24meckel's diverticulum10.5
25lipoma10.5
26rectal prolapse10.5
27adenocarcinoma10.4
28duodenitis10.4
29gastroduodenitis10.4
30adenoma10.4
31gastrointestinal stromal tumor10.3
32intestinal atresia10.3
33melanoma10.3
34cystadenoma10.2
35lipomatosis10.2
36sarcoma10.2
37tuberculosis10.2
38gastric outlet obstruction10.2
39anisakiasis10.1
40appendicitis10.1
41celiac disease10.1
42ascending cholangitis10.1
43pneumatosis cystoides intestinalis10.1
44endometriosis10.1
45hodgkin's lymphoma10.1
46lymphangioma10.1
47purpura10.1
48inflammatory myofibroblastic tumor10.1
49jejunal atresia10.1
50cardiac tamponade10.1F8

Graphical network of the top 20 diseases related to Intussusception:



Diseases related to intussusception

Symptoms for Intussusception

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47OMIM
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Clinical features from OMIM:

147710

Drugs & Therapeutics for Intussusception

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Intussusception

Search NIH Clinical Center for Intussusception

Genetic Tests for Intussusception

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Anatomical Context for Intussusception

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33MalaCards
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MalaCards organs/tissues related to Intussusception:

33
Colon, Appendix, Small intestine, Pancreas, Lung, B cells, Breast, Liver, Endothelial, Skeletal muscle, Myeloid, Heart

Animal Models for Intussusception or affiliated genes

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Sources:
37MGI
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Publications for Intussusception

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Sources:
52PubMed
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Articles related to Intussusception:

(show top 50)    (show all 710)
idTitleAuthorsYear
1
Colo-colic intussusception secondary to lipomatous polyp in an adult. (23462651)
2013
2
Intussusception with complete twisting of mesenteric root after Roux-en-Y gastric bypass. (23522620)
2013
3
Aortic intussusception complicating diagnostic angiography: recognition and management. (23608257)
2013
4
Perspectives on intussusception. (23597529)
2013
5
Colonic intussusception caused by anisakiasis: a case report and review of the literature. (23318852)
2013
6
Jejunal intussusception and polyps with different types of malignant transformation in Peutz-Jeghers syndrome: Report of a case. (23255928)
2013
7
Appendicular intussusception with lymphoid hyperplasia. (23847834)
2013
8
Intussusception risk and disease prevention associated with rotavirus vaccines in Australia's National Immunization Program. (23964090)
2013
9
Management of intussusception in resource-limited settings. (23994003)
2013
10
Intussusception as a presenting feature of Burkitt lymphoma: implications for management and outcome. (21969235)
2012
11
Ileocolic intussusception due to a cecal endometriosis: case report and review of literature. (22676322)
2012
12
Antibiotics administration before enema reduction of intussusception: is it necessary? (22595575)
2012
13
Appendiceal intussusception to the cecum caused by mucocele of the appendix: Laparoscopic approach. (22706297)
2012
14
Japanese guidelines for the management of intussusception in children, 2011. (22748165)
2012
15
Prevalence of severe acute rotavirus gastroenteritis and intussusceptions in Ghanaian children under 5 years of age. (22337844)
2012
16
Sonographically guided enema for intussusception reduction: a safer alternative to fluoroscopy. (23011611)
2012
17
Strangulating ileocolic intussusception in pregnancy. (24293856)
2012
18
Intussusception: edematous ileocecal valve mimicking incomplete reduction. (22391932)
2012
19
The role of plain radiography in assessing intussusception with vascular compromise in children. (22291835)
2011
20
Intussusception: incidence and treatment-insights from the nationwide German surveillance. (21415671)
2011
21
Prolapsed sigmoid intussusception per anus in an elderly man: a case report. (21849068)
2011
22
Small bowel intussusception caused by a jejunal polyp in Peutz-Jeghers syndrome: a case treated with double balloon enteroscopy. (20658191)
2011
23
Laparoscopy-assisted hydrostatic in situ reduction of intussusception: A reasonable alternative? (21430840)
2011
24
Heterotopic gastric mucosa: a rare cause of jejunal intussusception. (21944611)
2011
25
Adenomyoma of the ileum leading to intussusception. (22110422)
2011
26
Intestinal spirochetosis as a causative factor for colocolic intussusception. (21274545)
2011
27
Incidence of intussusception in early infancy: a capture-recapture estimate for Germany. (21698555)
2011
28
Severe type of adult jejunal intussusception caused by long intestinal tube in a patient with intestinal obstruction due to cecal carcinoma. (22688937)
2011
29
Intussusception: an anatomical perspective with review of the literature. (21268121)
2011
30
Voluminous intussusception involving the whole midgut in a teenager: a unique differentiation from abdominal cocoon. (21512845)
2011
31
Multiple Small Bowel Intussusceptions Caused by Kaposi's Sarcoma: The Radiologist's Point of View. (21572620)
2011
32
Postoperative ileo-ileal intussusception following surgical resection of patent omphalomesenteric duct. (21484814)
2011
33
Paediatric intussusception caused by acquired immunodeficiency syndrome-associated Kaposi sarcoma. (20535484)
2010
34
A ganglioneuroma of the sigmoid colon presenting as leading point of intussusception in a child: a case report. (19159704)
2009
35
Contents of serum albumin after surgical operation in children with acute intussusception]. (19374811)
2009
36
HoxB5 induces endothelial sprouting in vitro and modifies intussusceptive angiogenesis in vivo involving angiopoietin-2. (19403561)
2009
37
Ileo-ileal intussusception due to inverted Meckel's diverticulum. (19803269)
2009
38
Massive mucinous cystadenoma of the appendix with intussusception in an adult: usefulness of reconstructed computed tomography images. (18301985)
2008
39
Intussusception mimicking rectal prolapse. (18327576)
2008
40
Multiple lipomatosis--a rare cause for small bowel intussusception. (18157202)
2007
41
Intussusception due to intestinal anisakiasis: a case report. (15160751)
2004
42
Delta-F508 cystic fibrosis mutation is not linked to intussusception: implications for rotavirus vaccine. (12969205)
2003
43
Laparoscopic reduction of an ileoileal intussusception and resection of an inverted Meckel's diverticulum in an adult. (12728389)
2003
44
Intestinal intussusception and occlusion caused by small bowel polyps in the Peutz-Jeghers syndrome. Management by combined intraoperative enteroscopy and resection through minimal enterostomy: case report. (11313662)
2000
45
Large-cell carcinoma of the lung. With major bleeding and intussusception. (1328355)
1992
46
Intussusception-type antireflux valve in the Roux-en-Y loop to prevent ascending cholangitis after hepatic portojejunostomy. (2313499)
1990
47
Small bowel obstruction by intussusception in a bladder diverticulum: complication of inguinal hernia repair. (3122870)
1987
48
Recurrent acute pancreatitis and intussusception complicating an intraluminal duodenal diverticulum. (6786954)
1981
49
Extramedullary plasmacytoma of the colon: a rare cause of intussusception. (889191)
1977
50
ACCESSORY PANCREAS WITH INTUSSUSCEPTION. (17863874)
1918

Variations for Intussusception

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Expression for genes affiliated with Intussusception

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Intussusception

Search GEO for disease gene expression data for Intussusception.

Pathways for genes affiliated with Intussusception

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Sources:
50PathCards, 38NCBI BioSystems Database, 5Cell Signaling Technology, 60Thomson Reuters, 53QIAGEN, 30KEGG, 12EMD Millipore
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Pathways related to Intussusception according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7CCND1, APC
2
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway60
9.6CRP, CCND1
39.4CRP, IL6
49.4APC, STK11, CCND1
59.4IL6, CCND1
69.4IL6, CCND1
7
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
9.3CD40LG, IL6, WAS
8
Show member pathways
PLK2 and PLK4 events38
Polo-like kinase signaling events in the cell cycle38
9.1STK11, CCND1, IL6
9
Show member pathways
9.1CD40LG, IL6, CCND1
109.1APC, CCND1, IL6
119.1IL6, CCND1, APC
12
Show member pathways
thioredoxin pathway38
8.9CRP, ALB, IL6
138.9CRP, ALB, F8, CFTR

Compounds for genes affiliated with Intussusception

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Sources:
45Novoseek, 11DrugBank, 51PharmGKB, 29IUPHAR, 24HMDB, 61Tocris Bioscience
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Compounds related to Intussusception according to GeneCards/GeneDecks:

(show top 50)    (show all 130)
idCompoundScoreTop Affiliating Genes
1refacto4510.0ALB, F8
2kogenate459.9ALB, F8
3sandoglobulin459.8CD40LG, IL6
4gamma globulin459.7ALB, CD40LG, CRP
5tocilizumab45 1110.7CRP, IL6
6p00001459.7CRP, F8, CCND1
7turpentine459.6IL6, CRP
8pmma459.5CD40LG, CRP, IL6
9iron sucrose459.5IL6, CRP
10okt3459.5IL6, CRP, CD40LG
11sulindac45 1110.5CCND1, APC, ALB
12vitamin b12459.4ALB, CD40LG, CRP
13fenofibrate45 51 1111.4IL6, CRP, CD40LG
14polyethylene glycol459.3ALB, F8, CD40LG, CRP
15dextran sulfate459.3IL6, ALB, CD40LG
16rituximab45 51 1111.3CD40LG, CRP, F8, IL6
17rosuvastatin45 51 29 1112.2ALB, CRP, IL6
18citrate459.2CRP, CFTR, F8, ALB
19endotoxin459.2CD40LG, IL6, CRP, F8
20aspirin45 51 29 2412.2CD40LG, CRP, APC, CFTR, F8
21celecoxib45 61 29 51 24 1114.2CCND1, APC, ALB
22cdp571459.1CRP, IL6
23paraffin459.1CD40LG, APC, CFTR, STK11, CCND1
24ibuprofen45 29 51 24 1113.1ALB, IL6, CFTR
25ascorbic acid45 2410.0ALB, CFTR, CD40LG, CRP
26neopterin459.0IL6, CRP, CD40LG
27adenylate459.0CCND1, CD40LG, CFTR, APC, STK11
28curcumin459.0IL6, APC, CFTR, CCND1
29prednisolone45 29 1111.0F8, ALB, IL6, CRP
30epinephrine45 24 1110.9IL6, CD40LG, CFTR, F8, APC
31aspartate458.9CFTR, F8, ALB, CRP, CD40LG
32folate458.9CRP, APC, CCND1, ALB, CD40LG
33rosiglitazone29 45 51 24 1112.9CRP, ALB, CCND1, IL6
34rapamycin458.9CRP, CD40LG, CCND1, STK11, WAS, APC
35methotrexate51 45 1110.8CRP, IL6, ALB, CCND1
36ivig458.8IL6, ALB, CRP, CD40LG, F8
37n acetylcysteine458.7CD40LG, CFTR, CRP, CCND1, IL6
38indomethacin45 29 61 1111.7CD40LG, ALB, IL6, APC, CFTR
39fibrinogen458.7CD40LG, CRP, ALB, IL6, F8
40lactate458.7IL6, F8, ALB, CRP, CD40LG
41creatinine458.7ALB, F8, CRP, IL6, CD40LG
42vitamin d458.6APC, IL6, ALB, CFTR
43norepinephrine45 24 1110.6APC, F8, CD40LG, CFTR, IL6, CRP
44serine458.5F8, WAS, STK11, APC, CFTR, CD40LG
45vegf458.5STK11, CCND1, CRP, IL6, F8, CD40LG
46estrogen458.4CFTR, APC, CCND1, IL6, F8, CD40LG
47glucose458.3CRP, ALB, F8, IL6, STK11, APC
48lipid458.1F8, IL6, WAS, STK11, ALB, CRP
49alanine458.1CRP, CD40LG, ALB, F8, IL6, STK11
50testosterone45 61 24 1110.9CD40LG, ALB, IL6, CCND1, APC, CFTR

GO Terms for genes affiliated with Intussusception

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16Gene Ontology
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Cellular components related to Intussusception according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.6ALB, F8
2extracellular spaceGO:0056158.0CD40LG, CRP, ALB, F8, IL6

Biological processes related to Intussusception according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of epithelial cell proliferation involved in prostate gland developmentGO:06077010.0APC, STK11
2canonical Wnt signaling pathwayGO:0600709.6CCND1, STK11, APC
3muscle cell cellular homeostasisGO:0467169.6IL6, APC
4negative regulation of lipid storageGO:0108889.6IL6, CRP
5cellular response to DNA damage stimulusGO:0069749.4CCND1, STK11, APC
6acute-phase responseGO:0069539.3CRP, F8, IL6
7defense response to Gram-positive bacteriumGO:0508309.3IL6, CRP
8inflammatory responseGO:0069549.1CD40LG, CRP, IL6
9platelet activationGO:0301688.9IL6, F8, ALB, CD40LG
10response to drugGO:0424938.7IL6, CCND1, CFTR

Molecular functions related to Intussusception according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1enzyme bindingGO:0198999.1ALB, CCND1, CFTR
2protein bindingGO:0055156.6CRP, CFTR, APC, WAS, STK11, CCND1

Products for genes affiliated with Intussusception

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Intussusception

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet