MCID: INT051
MIFTS: 50

Intussusception malady

Categories: Gastrointestinal diseases

Aliases & Classifications for Intussusception

Aliases & Descriptions for Intussusception:

Name: Intussusception 12 29 52 42 14
Invagination of Intestine or Colon 12
Intussusception of Intestine 12
Intussusception Nos 12

Characteristics:

HPO:

32
intussusception:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

Disease Ontology 12 DOID:8446
ICD10 33 K56.1
ICD9CM 35 560.0
MeSH 42 D007443
NCIt 47 C113484
UMLS 69 C0021933

Summaries for Intussusception

MalaCards based summary : Intussusception, also known as invagination of intestine or colon, is related to celiac disease and colon adenocarcinoma. An important gene associated with Intussusception is STK11 (Serine/Threonine Kinase 11), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Vaccines and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include colon, appendix and small intestine, and related phenotypes are homeostasis/metabolism and hematopoietic system

Related Diseases for Intussusception

Diseases related to Intussusception via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 331)
id Related Disease Score Top Affiliating Genes
1 celiac disease 29.7 CD40LG CD79A CRP
2 colon adenocarcinoma 29.4 BAG6 CRP IL6
3 typhoid fever 29.4 CD40LG CD79A CFTR
4 histiocytosis 29.4 CD79A CRP IL6
5 leiomyosarcoma 29.2 CD40LG CD79A CRP
6 coloboma of iris 10.3 CRP IL6
7 polycythemia due to hypoxia 10.3 CD40LG CRP
8 cannabis dependence 10.3 CD40LG CRP
9 cutaneous sclerosis 10.3 CRP IL6
10 shoulder impingement syndrome 10.3 CRP IL6
11 unilateral multicystic dysplastic kidney 10.2 CRP IL6
12 alcoholic neuropathy 10.2 CD40LG CD79A
13 camptodactyly vertebral fusion 10.2 CD40LG CD79A
14 spinal polio 10.2 CD40LG CD79A
15 rabies 10.2 CD40LG CD79A
16 unilateral retinoblastoma 10.2 CD40LG CD79A
17 mesangial proliferative glomerulonephritis 10.2 CD40LG CD79A
18 delta chain disease 10.2 CD40LG CD79A
19 discitis 10.2 CD40LG CD79A
20 spinal canal and spinal cord meningioma 10.2 CD40LG CD79A
21 trichostrongyloidiasis 10.2 CD40LG CD79A
22 colloid adenoma 10.2 CD40LG CD79A
23 heart septal defect 10.2 CD40LG CD79A
24 neutrophilia, hereditary 10.2 CRP IL6
25 cutaneous polyarteritis nodosa 10.2 CD40LG CD79A
26 mild pre-eclampsia 10.2 CD40LG CD79A
27 retinal microaneurysm 10.2 CD40LG CD79A
28 pediatric meningioma 10.2 CD40LG CD79A
29 tonsil cancer 10.2 CD40LG CD79A
30 indomethacin antenatal infection 10.2 CD40LG CD79A
31 postcricoid region cancer 10.2 CD40LG CD79A
32 beach ear 10.2 CD40LG CD79A
33 acute kidney tubular necrosis 10.2 CD40LG CD79A
34 atheroembolism of kidney 10.2 CD40LG CD79A
35 partial sensory epilepsy 10.2 CD40LG CD79A
36 swine influenza 10.2 CRP IL6
37 ritscher-schinzel syndrome 1 10.2 CD40LG CD79A
38 diabetic angiopathy 10.2 CD40LG CD79A
39 endocarditis 10.2 CD40LG CD79A
40 muscular dystrophy 10.2 CD40LG CD79A
41 dumping syndrome 10.2 CD40LG CD79A
42 striatonigral degeneration 10.2 CD40LG CD79A
43 ciliary body spindle cell melanoma 10.2 CD40LG CD79A
44 purulent endophthalmitis 10.2 CD40LG CD79A
45 mu chain disease 10.2 CD40LG CD79A
46 peutz-jeghers syndrome 10.2
47 bursitis 10.2 CD40LG CD79A
48 benign mediastinal neurilemmoma 10.2 CD79A CFTR
49 syphilis 10.2 CD40LG CD79A
50 inner ear disease 10.2 CD40LG IL6

Graphical network of the top 20 diseases related to Intussusception:



Diseases related to Intussusception

Symptoms & Phenotypes for Intussusception

Human phenotypes related to Intussusception:

32
id Description HPO Frequency HPO Source Accession
1 intussusception 32 HP:0002576

MGI Mouse Phenotypes related to Intussusception:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.96 BAG6 CD40LG CD79A CFTR CRP ENG
2 hematopoietic system MP:0005397 9.92 CD40LG CD79A CFTR ENG IL6 STK11
3 cardiovascular system MP:0005385 9.91 CD40LG CRP ENG IL6 STK11 TEK
4 nervous system MP:0003631 9.76 BAG6 CD40LG CD79A ENG IL6 STK11
5 renal/urinary system MP:0005367 9.43 BAG6 CD40LG CD79A IL6 STK11 VEGFA
6 respiratory system MP:0005388 9.1 IL6 STK11 VEGFA BAG6 CFTR ENG

Drugs & Therapeutics for Intussusception

Drugs for Intussusception (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 4,Phase 3,Phase 1,Phase 2
2 Pharmaceutical Solutions Phase 3
3 Citrate Nutraceutical Phase 3
4
Citric Acid Nutraceutical, Vet_approved Phase 3 77-92-9 311
5
Hydrocortisone Approved, Vet_approved 50-23-7 5754 657311
6
Butyric Acid Experimental 107-92-6 264
7 Hemostatics
8 Cortisol succinate
9 Hydrocortisone 17-butyrate 21-propionate
10 Hydrocortisone acetate
11 Hydrocortisone-17-butyrate
12 Anti-Inflammatory Agents

Interventional clinical trials:

(show all 30)
id Name Status NCT ID Phase
1 RCT: STARR vs Biofeedback Completed NCT00556283 Phase 4
2 Study of Stapled Transanal Rectal Resection (STARR) Surgery in Refractory Constipation Associated With Obstructive Defecation Syndrome (ODS) Completed NCT00256984 Phase 4
3 Stapled Trans Anal Rectal Resection (STARR) for Outlet Obstruction: Functional and Morphological Outcome Completed NCT00521872 Phase 4
4 Potential Mechanisms for Intussusception After Rotavirus Vaccine-Pilot Study Active, not recruiting NCT02542462 Phase 4
5 Optimising Rotavirus Vaccine in Aboriginal Children Not yet recruiting NCT02941107 Phase 4
6 A Phase III Clinical Trial to Evaluate the Protective Efficacy of Three Doses of Oral Rotavirus Vaccine (ORV) 116E Unknown status NCT01305109 Phase 3
7 A Study to Test 2 Doses of GSK Biologicals' Oral Live Attenuated Human Rotavirus (HRV) Vaccine in Healthy Infants Completed NCT00197210 Phase 3
8 A Study to Test 2 Doses of the HRV Vaccine in Healthy Infants. Completed NCT00140673 Phase 3
9 Long-term Efficacy and Safety of Subjects Approximately 3 Years After Priming With 2 Doses of GSK Bio's HRV Vaccine. Completed NCT00420316 Phase 3
10 Rotavirus Efficacy and Safety Trial (REST)(V260-006) Completed NCT00090233 Phase 3
11 A Study of the Immunogenicity, Tolerability, and Safety of a New Formulation of RotaTeq™ in Infants (V260-035) Completed NCT01600092 Phase 3
12 Efficacy, Safety, and Immunogenicity of V260 in Healthy Chinese Infants (V260-024) Completed NCT02062385 Phase 3
13 Efficacy and Safety of a Pentavalent Rotavirus Vaccine (BRV-PV) Against Severe Rotavirus Gastroenteritis in Niger Recruiting NCT02145000 Phase 3
14 Dose Escalation Study to Evaluate Oral Rotavirus Vaccine 116E Live Attenuated in Healthy Infants 8 to 20 Weeks Old Unknown status NCT00439660 Phase 1, Phase 2
15 Safety and Immunogenicity of Rotavirus Vaccine (RotaTeq(R)) in Infants With Short Bowel Syndrome Completed NCT00767364 Phase 1
16 Surgical Treatment of Obstructed Defecation Syndrome Unknown status NCT01899209
17 Evaluation of Universal Rotavirus Vaccination Program Unknown status NCT01273077
18 Study to Assess the Incidence of Intussusception in Children < 2 Years of Age in Singapore Completed NCT01177839
19 Intussusception Surveillance After Rotarix Introduction in Mexico Completed NCT00595205
20 Study on the Incidence of Intussusception (IS) in Children Aged < 12 Months in Japan Completed NCT01479491
21 Implementing Hospital-based Active Surveillance Procedures for Vaccine Safety Monitoring at IMSS Hospitals in Mexico Completed NCT00436358
22 Stapled TransAnal Rectal Resection (STARR) With Contour® TranstarTM Completed NCT00673400
23 Special Drug Use Investigation for ROTARIX® Completed NCT01636739
24 Drug Use Investigation for ROTARIX® Completed NCT01636193
25 Long Term Results of STARR With Contour Transtar Completed NCT02971332
26 Safety Study of GSK Biologicals' Rotavirus Vaccine (Rotarix®) Administered to Children Aged <1 Year in the United States Completed NCT00875641
27 Obstructed Defaecation: Proctography Versus Ultrasound in Symptomatic Patients Completed NCT02239302
28 Effect of Hydrocortisone on Improving Outcome of Pneumatic Reduction of Infantile Intussusception Recruiting NCT02691858
29 Correlation of Anal Acoustic Reflectometry Parameters With Degree of Rectal Intussusception and Prolapse Recruiting NCT02774798
30 Does the Stapled Transanal Rectal Resection (STARR Procedure) Has an Effect on Anal Compliance ? Recruiting NCT02052063

Search NIH Clinical Center for Intussusception

Cochrane evidence based reviews: intussusception

Genetic Tests for Intussusception

Genetic tests related to Intussusception:

id Genetic test Affiliating Genes
1 Intussusception 29

Anatomical Context for Intussusception

MalaCards organs/tissues related to Intussusception:

39
Colon, Appendix, Small Intestine, Pancreas, Lung, B Cells, Breast

Publications for Intussusception

Articles related to Intussusception:

(show top 50) (show all 881)
id Title Authors Year
1
Intussusception in Premature Baby: Unusual Cause of Bowel Obstruction and Perforation. ( 28083499 )
2017
2
Incidence of acute intussusception among infants in eastern France: results of the EPIstudy trial. ( 28058530 )
2017
3
Unparalleled patterns of intussusception and rotavirus gastroenteritis hospitalization rates among children younger than six years in Italy. ( 28067936 )
2017
4
Hospitalization rates for intussusception in children aged 0-59A months from 2009 to 2014 in Italy. ( 28075671 )
2017
5
Unusual ultrasound appearance of small bowel intussusception and secondary bowel obstruction in a child with Peutz-Jeghers syndrome. ( 28314199 )
2017
6
An intestinal carcinoid causing transient jejunal intussusception in an adult-A case report. ( 28092782 )
2017
7
Say What? Bannayan-Riley-Ruvalcaba Syndrome Presenting with Gastrointestinal Bleeding Due to Hamartoma-Induced Intussusception. ( 28168574 )
2017
8
BRUNNER GLAND ADENOMA MASQUERADING AS DUODENAL GASTROINTESTINAL STROMAL TUMOR WITH INTUSSUSCEPTION: CASE REPORT. ( 28489176 )
2017
9
Gastroduodenojejunal Intussusception: A Very Rare Complication of a Pedunculated Gastric Harmatomatous Giant Polyp. ( 28050044 )
2017
10
Burkitt lymphoma as a lead point for jejunojejunal intussusception in a human immunodeficiency virus patient. ( 28523628 )
2017
11
Appendiceal intussusception from endometriosis: endoscopic and laparoscopic approach. ( 27551900 )
2016
12
Transverse Colon Submucosal Lipoma Presenting With Colocolic Intussusception. ( 27144190 )
2016
13
Successful management of adult lymphoma-associated intussusception by laparoscopic reduction and appendectomy. ( 27217710 )
2016
14
Ileo-ileal Intussusception and Bowel Obstruction Caused by Plasmablastic Lymphoma of Small Bowel- A Rare Entity in Rare Location. ( 27134931 )
2016
15
A Case of Intussusception Associated with Pneumatosis Cystoides Intestinalis. ( 27721738 )
2016
16
Acute Pancreatitis and Gastroduodenal Intussusception Induced by an Underlying Gastric Gastrointestinal Stromal Tumor: A Case Report. ( 27104028 )
2016
17
Giant ileocolic intussusception in an adult induced by a double ileal lipoma: a case report with pathologic correlation. ( 27594938 )
2016
18
Retrograde Jejunogastric Intussusception: A Rare Cause of Abdominal Pain. ( 27144188 )
2016
19
A case of small bowel metastasis from spinal Ewing sarcoma causing intussusception in an adult female. ( 27083867 )
2016
20
Two Cases of Aortic Intimal Intussusception During Endovascular Repair of an Acute Type B Dissection. ( 27099283 )
2016
21
Synovial sarcoma presenting as colonic intussusception in a child. ( 27572305 )
2016
22
Trapped among the waves: massive jejunojejunal intussusception after gastric bypass. ( 27154782 )
2016
23
Enteric duplication cyst as a leading point for ileoileal intussusception in an adult: A rare cause of complete small intestinal obstruction. ( 27358681 )
2016
24
Colonic Adenocarcinoma Presenting as Sigmoidorectal Intussusception: A Consideration for Intussusception Reduction. ( 27657559 )
2016
25
Jejunojejunostomy intussusception after gastric bypass: Case report of a rare but serious complication. ( 28006717 )
2016
26
Total duodenal necrosis with retroperitoneal perforation in an adolescent with jejunal intussusception. ( 27206647 )
2016
27
A review of intussusception cases involving failed pneumatic reduction and re-intussusception. ( 27598590 )
2016
28
An Unusual Intussusception. ( 27179551 )
2016
29
Rotavirus Vaccine and Intussusception Hospitalizations. ( 27558937 )
2016
30
Simultaneous occurrence of intussusception and duodenal haematoma in a patient with Glanzmann's thrombasthenia. ( 28051053 )
2016
31
Risk of Intussusception with Rotavirus Vaccine. ( 27641974 )
2016
32
Mixed Adenoneuroendocrine Carcinoma Causing Colonic Intussusception. ( 27525153 )
2016
33
Aortic Root Intussusception During Transcatheter Aortic Valve Replacement. ( 27639901 )
2016
34
Multiple Intussusceptions in Peutz-Jeghers Syndrome: Detection through Multidetector Computerized Tomography Enterography. ( 27270555 )
2016
35
Systematic review shows that pathological lead points are important and frequent in intussusception and are not limited to infants. ( 27588829 )
2016
36
Lipoma-induced colonic intussusception in mobile cecum syndrome. ( 28007681 )
2016
37
Clinics in diagnostic imaging (172). Colocolic intussusception with a lipoma as the lead point. ( 27995264 )
2016
38
Laparoscopic Treatment of Intussusception after Roux-en-Y Gastric Bypass. ( 27919833 )
2016
39
Appendix Invagination Mimicking Ileocecal Intussusception in a PediatricA Patient: A Case Report. ( 27623217 )
2016
40
Epidemiology of intussusception in New Zealand pre-rotavirus vaccination. ( 27657157 )
2016
41
Ileocecal Intussusception Caused by an Appendiceal Neoplasm. ( 26831058 )
2016
42
Dacron Graft Intussusception Technique for Treatment of Type A Aortic Dissections: Technical Notes and Preliminary Results. ( 27556309 )
2016
43
Terminal ilial intussusception in an adult due to endometriosis. ( 27112327 )
2016
44
Inverted Meckel diverticulum as a lead point of small bowel intussusception: misinterpreting case as a lipoma. ( 27179156 )
2016
45
A Case of Giant Colonic Muco-submucosal Elongated Polyps Associated with Intussusception. ( 27214574 )
2016
46
Peutz-Jeghers syndrome complicated with small bowel intussusception managed by laparoscopy-assisted transoral single-balloon enteroscopy. ( 27352980 )
2016
47
PATTERNS AND SEASONAL VARIATION OF INTUSSUSCEPTION IN CHILDREN: A RETROSPECTIVE ANALYSIS OF CASES OPERATED IN A TERTIARY HOSPITAL IN ETHIOPIA. ( 27191025 )
2016
48
Childhood intussusception: Impact of delay in presentation in a developing country. ( 28051044 )
2016
49
Intestinal plasmacytoma causing colocolic double intussusception in an adult dog. ( 27925660 )
2016
50
Mesenteric Meckel's diverticulum: an unusual cause of small bowel intussusception. ( 27060074 )
2016

Variations for Intussusception

Expression for Intussusception

Search GEO for disease gene expression data for Intussusception.

Pathways for Intussusception

GO Terms for Intussusception

Cellular components related to Intussusception according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.26 CD40LG CD79A ENG IL6
2 cell surface GO:0009986 9.02 CD40LG CFTR ENG TEK VEGFA

Biological processes related to Intussusception according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.56 CRP ENG IL6 VEGFA
2 positive regulation of protein phosphorylation GO:0001934 9.54 ENG TEK VEGFA
3 positive regulation of angiogenesis GO:0045766 9.5 ENG TEK VEGFA
4 branching involved in blood vessel morphogenesis GO:0001569 9.48 ENG VEGFA
5 sprouting angiogenesis GO:0002040 9.46 ENG TEK
6 positive regulation of focal adhesion assembly GO:0051894 9.43 TEK VEGFA
7 artery morphogenesis GO:0048844 9.4 ENG VEGFA
8 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.33 IL6 STK11 VEGFA
9 negative regulation of apoptotic process GO:0043066 9.02 BAG6 CD40LG IL6 TEK VEGFA
10 negative regulation of lipid storage GO:0010888 8.96 CRP IL6

Sources for Intussusception

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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