Intussusception malady

MalaCards: Intussusception, also known as intussusception (morphologic abnormality), is related to colon carcinoma and colon cancer. An important gene associated with Intussusception is STK11 (serine/threonine kinase 11), and among its related pathways is Selected targets of HNF1. The compounds polyethylene glycol and gamma globulin have been mentioned in the context of this disorder. Affiliated tissues include colon and endothelial, and related mouse phenotypes are endocrine/exocrine gland and renal/urinary system.

Aliases & Descriptions:

intussusception 6 8 32 43 intussusception (morphologic abnormality) 6 intussusception of intestine (disorder) 6

intussusception nos (disorder) 6 invagination of intestine 6 colon 6

Diseases related to intussusception by text searches and GeneDecks gene sharing:

(show top 50)    (show all 636)

id	Related Disease	Score	Top Affiliating Genes
1	colon carcinoma	36.7	VEGFA, CFTR, IL6, APC, ANGPT2, CCND1
2	colon cancer	36.7	VEGFA, CFTR, CD40LG, IL6, APC, ANGPT2
3	ulcerative colitis	33.2	CFTR, IL6, APC, CRP
4	carcinoma	32.8	VEGFA, CFTR, CD40LG, FLG2, IL6, APC
5	adenocarcinoma	30.8	VEGFA, CFTR, CD40LG, IL6, APC, ANGPT2
6	breast cancer	30.8	VEGFA, IL6, CCND1, STK11
7	inflammatory bowel disease	29.0	WAS, VEGFA, CD40LG, IL6, APC, ANGPT2
8	colorectal cancer	28.6	VEGFA, IL6, APC, ANGPT2, CCND1, F8
9	lung carcinoma	28.1	VEGFA, CFTR, ANGPT2, CCND1, CYR61, STK11
10	crohn's disease	28.1	VEGFA, CFTR, CD40LG, IL6, ANGPT2, ALB
11	peutz-jeghers syndrome	28.0	APC, STK11, EPB41L5
12	familial adenomatous polyposis	27.4	CD40LG, APC, CCND1, STK11
13	neuronitis	26.8	WAS, VEGFA, CFTR, CD40LG, IL6, APC
14	duodenitis	26.8	CFTR, CD40LG, IL6, APC, CCND1, ALB
15	hypercalcemia	26.6	IL6, CCND1, ALB, CRP
16	hypoxia	26.6	VEGFA, CFTR, CD40LG, IL6, APC, ANGPT2
17	appendicitis	26.5	IL6, ALB, CRP
18	juvenile polyposis syndrome	26.4	APC, STK11
19	hemophilia	26.3	CD40LG, IL6, F8, ALB
20	alpha 1-antitrypsin deficiency	26.3	VEGFA, CFTR, CRP
21	atopic dermatitis	26.3	VEGFA, CD40LG, FLG2, IL6, ALB, EPO
22	dermatitis	26.2	VEGFA, CD40LG, FLG2, IL6, ALB, EPO
23	prostatitis	26.2	ZNF185, VEGFA, CFTR, CD40LG, IL6, APC
24	gastric cancer	26.2	VEGFA, CD40LG, IL6, APC, ANGPT2, CCND1
25	endometrial carcinoma	26.1	VEGFA, IL6, ANGPT2, CCND1, CYR61, EPO
26	acromegaly	26.0	VEGFA, IL6, APC, ALB, CRP
27	ovarian carcinoma	25.7	VEGFA, IL6, APC, ANGPT2, CCND1, ALB
28	prostate carcinoma	25.7	VEGFA, IL6, APC, ANGPT2, CCND1, CYR61
29	pancreatitis	25.7	WAS, VEGFA, CFTR, CD40LG, IL6, APC
30	gastritis	25.7	VEGFA, CD40LG, IL6, ALB
31	papillary thyroid carcinoma	25.7	APC, ANGPT2, CCND1
32	hepatitis	25.6	VEGFA, CFTR, CD40LG, IL6, APC, ANGPT2
33	aldosteronism	25.6	VEGFA, IL6, APC, ALB, EPO
34	lymphedema	25.5	VEGFA, CD40LG, ANGPT2
35	diarrhea	25.5	ZNF185, WAS, VEGFA, CFTR, CD40LG, IL6
36	ovarian cancer	25.5	VEGFA, IL6, APC, ANGPT2, CCND1, ALB
37	peritonitis	25.3	VEGFA, CD40LG, IL6, ANGPT2, ALB, CYR61
38	thrombophlebitis	25.3	F8, CRP, EPO
39	ischemia	25.3	VEGFA, CD40LG, IL6, ANGPT2, CCND1, ALB
40	herpes simplex	25.2	VEGFA, CFTR, CD40LG, IL6, APC, CCND1
41	immunodeficiency	25.2	WAS, VEGFA, CD40LG, IL6, ANGPT2, F8
42	pancreatic carcinoma	25.2	VEGFA, CFTR, IL6, CCND1, STK11
43	pancreatic cancer	25.1	WAS, VEGFA, CFTR, IL6, APC, CCND1
44	esophagitis	25.0	VEGFA, CFTR, IL6, APC, ANGPT2, CCND1
45	osteosarcoma	24.9	VEGFA, CD40LG, IL6, CCND1, CYR61, STK11
46	noma	24.8	VEGFA, IL6, APC, CCND1, ALB, CRP
47	gastrointestinal stromal tumor	24.8	VEGFA, ANGPT2, CCND1, ALB
48	hepatocellular carcinoma	24.8	VEGFA, IL6, APC, ANGPT2, CCND1, F8
49	infectious mononucleosis	24.7	CD40LG, IL6, CRP
50	liver cancer	24.6	VEGFA, IL6, APC, ANGPT2, CCND1, ALB

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to intussusception:

²²

MGI Mouse Phenotypes related to intussusception:

²⁵ (show all 13)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	9.7	PPT2, CD40LG, WAS
2	renal/urinary system phenotype	MP:0005367	9.6	STK11, APC, WAS
3	integument phenotype	MP:0010771	9.3	APC, ANGPT2, CCND1, STK11
4	liver/biliary system phenotype	MP:0005370	8.6	EPO, PPT2, IL6, CFTR, VEGFA
5	immune system phenotype	MP:0005387	8.3	STK11, PPT2, F8, CCND1, IL6, CFTR
6	digestive/alimentary phenotype	MP:0005381	8.3	WAS, EPB41L5, STK11, PPT2, ANGPT2, APC
7	reproductive system phenotype	MP:0005389	8.1	VEGFA, IL6, APC, CCND1, F8, STK11
8	vision/eye phenotype	MP:0005391	7.5	STK11, CCND1, ANGPT2, APC, IL6, CFTR
9	mortality/aging	MP:0010768	7.0	EPB41L5, STK11, PPT2, CYR61, F8, CCND1
10	hematopoietic system phenotype	MP:0005397	6.8	EPO, STK11, PPT2, F8, CCND1, APC
11	cardiovascular system phenotype	MP:0005385	6.6	EPO, EPB41L5, STK11, CRP, CYR61, CCND1
12	cellular phenotype	MP:0005384	6.6	CYR61, PPT2, STK11, EPB41L5, EPO, CCND1
13	homeostasis/metabolism phenotype	MP:0005376	5.3	EPO, STK11, CRP, ALB, F8, CCND1

Articles related to intussusception:

(show all 12)

id	Title	Authors	Year	Affiliating Genes
1	Intussusceptive microvascular growth in human glioma. (19882213)	Nico B.... Ribatti D.	2010	VEGFA
2	Contents of serum albumin after surgical operation in children with acute intussusception. (19374811)	Xia C.... He S.J.	2009	ALB
3	HoxB5 induces endothelial sprouting in vitro and modi fies intussusceptive angiogenesis in vivo involving angiopoietin-2. (19403561)	Winnik S.... Moser M.	2009	ANGPT2
4	Mantle cell lymphoma of the gastrointestinal tract pr esenting with multiple intussusceptions--case report and review of literature. (19646237)	Kella V.K.... King S.	2009	CCND1
5	Burkitt lymphoma-induced ileocolic intussusception in Wiskott-Aldrich syndrome. (16394894)	Pasic S.... Grujic B.	2006	WAS
6	STK11 status and intussusception risk in Peutz-Jeghers syndrome. (16882735)	Hearle N.... Houlston R.S.	2006	STK11
7	Intramural hematoma of the cecum as the lead point of intussusception in an elderly patient with hemophilia A: report of a case. (16715431)	Nakayama Y.... Itoh H.	2006	F8
8	Microvascular density, vascular endothelial growth factor immunoreactivity in tumor cells, vessel diameter and intussusceptive microvascular growth in primary melanoma. (15944771)	Ribatti D.... Sirigu P.	2005	VEGFA
9	Recombinant human erythropoietin induces intussusceptive microvascular growth in vivo. (14671634)	Crivellato E.... Ribatti D.	2004	EPO
10	Delta-F508 cystic fibrosis mutation is not linked to intussusception: implications for rotavirus vaccine. (12969205)	Barnes G.... Francis I.	2003	CFTR
11	APC gene mutations in a jejunal adenoma causing intussusception in a patient with familial adenomatous polyposis. (12522539)	Ishida H.... Miyaki M.	2002	APC
12	Endotoxin, cytokines and lipid peroxides in children with intussusception. (11412262)	Willetts I.E.... Stringer M.D.	2001	IL6, CD40LG, CRP

Genes related to intussusception according to GeneCards:

(show all 19)

id	Symbol	Description	Score	GeneCards Section Context
1	STK11	serine/threonine kinase 11	11.0	Publications
2	PRB3	proline-rich protein BstNI subfamily 3	11.0
3	FLG2	filaggrin family member 2	11.0
4	PPT2	palmitoyl-protein thioesterase 2	11.0
5	CYR61	cysteine-rich, angiogenic inducer, 61	11.0	Pathways & Interactions
6	ZNF185	zinc finger protein 185 (LIM domain)	11.0
7	WAS	Wiskott-Aldrich syndrome	11.0	Publications
8	ANGPT2	angiopoietin 2	11.0	Publications
9	EPB41L5	erythrocyte membrane protein band 4.1 like 5	11.0	Disorders
10	APC	adenomatous polyposis coli	11.0	Publications
11	CD40LG	CD40 ligand	11.0	Publications
12	F8	coagulation factor VIII, procoagulant component	11.0	Publications
13	EPO	erythropoietin	11.0	Publications
14	CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	11.0	Publications
15	CCND1	cyclin D1	11.0	Publications
16	VEGFA	vascular endothelial growth factor A	11.0	Publications
17	ALB	albumin	11.0	Publications
18	CRP	C-reactive protein, pentraxin-related	11.0	Publications
19	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications

Pathways related to intussusception according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Selected targets of HNF110	8.3	CFTR, F8, ALB, CRP

Compounds related to intussusception according to GeneDecks:

(show top 50)    (show all 87)

id	Compound	Score	Top Affiliating Genes
1	polyethylene glycol32	10.5	F8
2	gamma globulin32	10.3	ALB
3	citrate phosphate dextrose32	10.0	EPO, F8
4	rapamycin32 42	11.0	STK11, WAS, VEGFA
5	pge232	9.9	APC, ANGPT2, CFTR
6	refacto32	9.8	F8, ALB
7	ivig32	9.8	CRP, F8
8	epinephrine32 9 18 9	12.7	CFTR, APC, F8
9	aspartate32	9.7	CFTR, CD40LG, F8
10	pmma32	9.6	CRP, CD40LG
11	ascorbic acid32 18	10.6	CD40LG, EPO, CFTR
12	tween 8032	9.6	F8, ALB, EPO
13	phenylbutyrate32	9.6	EPO, CFTR, CCND1
14	heparin32 9 18 9	12.5	CYR61, F8, ALB
15	kogenate32	9.5	F8, ALB
16	triamcinolone acetonide32	9.5	EPO, VEGFA, CFTR
17	progestin32	9.5	F8, VEGFA, CCND1
18	estrogen32	9.4	APC, ANGPT2, F8, CYR61, CFTR
19	iron sucrose32	9.2	IL6, CRP, EPO
20	bucillamine32	9.0	IL6, CRP, VEGFA
21	bortezomib32 9 9	11.0	CD40LG, VEGFA, IL6, CCND1
22	celecoxib32 42 34 9 18 9	14.0	EPO, CCND1, ANGPT2, APC, VEGFA
23	p0000132	8.9	CRP, CCND1
24	perindopril32 34 9 9	11.9	VEGFA, CRP, ALB
25	rituximab32 34 9 9	11.8	CRP, CD40LG, IL6, F8
26	polysulfone32	8.8	EPO, CRP, ALB
27	infliximab32 9 9	10.7	IL6, VEGFA, CRP, ANGPT2
28	vitamin b1232	8.7	CRP, EPO, CD40LG, ALB
29	thalidomide32 42 9 9	11.7	EPO, IL6, CCND1, CD40LG, VEGFA
30	curcumin32	8.7	CCND1, CFTR, IL6, VEGFA, APC
31	aspirin32 34 18	10.7	CFTR, CD40LG, APC, F8, CRP
32	prostacyclin32	8.6	VEGFA, CRP, CYR61, F8, APC
33	cyclosporin a32 42	9.6	CFTR, CD40LG, IL6, F8, EPO, ANGPT2
34	ly29400232	8.6	CRP, CCND1, VEGFA, IL6
35	atorvastatin32 34 9 18 9	12.5	CD40LG, VEGFA, CRP, IL6
36	indomethacin32 9 9	10.5	CFTR, APC, CD40LG, ALB, IL6
37	paraffin32	8.4	VEGFA, ANGPT2, STK11, CCND1, APC, CD40LG
38	fibrinogen32	8.3	ANGPT2, CRP, IL6, CD40LG, ALB
39	vitamin d32	8.3	IL6, APC, EPO, ALB, CFTR
40	norepinephrine32 9 18 9	11.2	IL6, CRP, CD40LG, F8, CFTR, APC
41	prednisolone32 9 9	10.1	F8, CRP, ALB, IL6
42	n acetylcysteine32	7.8	CRP, CD40LG, CCND1, CFTR, IL6, VEGFA
43	lactate32	7.8	EPO, CRP, CD40LG, ALB, F8, IL6
44	folate32	7.8	CRP, CD40LG, APC, CCND1, ALB, CYR61
45	creatinine32	7.6	ALB, F8, EPO, IL6, ANGPT2, CRP
46	alanine32	7.4	ALB, CFTR, CD40LG, IL6, F8, CRP
47	lipid32	7.3	STK11, CRP, CYR61, ALB, F8, APC
48	tyrosine32	7.2	WAS, CYR61, IL6, CCND1, ANGPT2, APC
49	testosterone32 9 18 9	10.1	APC, CCND1, CRP, ALB, CD40LG, CFTR
50	vegf32	6.9	F8, CYR61, CCND1, STK11, ANGPT2, IL6

Cellular components related to intussusception according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	platelet alpha granule lumen	GO:031093	9.0	VEGFA, F8, ALB
2	extracellular space	GO:005615	6.6	VEGFA, EPO, CRP, ALB, F8, ANGPT2
3	extracellular region	GO:005576	6.3	EPO, PRB3, CRP, CYR61, ALB, F8

Biological processes related to intussusception according to GeneDecks:

(show all 10)

id	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of epithelial cell proliferation involved in prostate gland development	GO:060770	10.1	STK11, APC
2	positive regulation of focal adhesion assembly	GO:051894	9.7	VEGFA, EPB41L5
3	canonical Wnt receptor signaling pathway	GO:060070	9.6	APC, CCND1, STK11
4	negative regulation of lipid storage	GO:010888	9.2	CRP, IL6
5	positive regulation of protein phosphorylation	GO:001934	9.2	VEGFA, CCND1, CYR61
6	acute-phase response	GO:006953	9.0	IL6, F8, CRP
7	platelet degranulation	GO:002576	8.7	ALB, F8, VEGFA
8	blood coagulation	GO:007596	8.5	ALB, F8, ANGPT2, VEGFA, WAS
9	platelet activation	GO:030168	8.3	ALB, F8, IL6, CD40LG, VEGFA
10	negative regulation of apoptotic process	GO:043066	8.1	VEGFA, IL6, APC, ALB, CYR61, EPO