COLON
MCID: INT051
MIFTS: 58

Intussusception (COLON) malady

Gastrointestinal diseases category

Summaries for Intussusception

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48OMIM, 34MalaCards
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MalaCards: Intussusception, also known as intussusception of intestine, is related to peutz-jeghers syndrome and intestinal obstruction. An important gene associated with Intussusception is STK11 (serine/threonine kinase 11), and among its related pathways are Presenilin action in Notch and Wnt signaling and Jak/Stat Pathway. The compounds refacto and kogenate have been mentioned in the context of this disorder. Affiliated tissues include colon, appendix and small intestine, and related mouse phenotypes are reproductive system and liver/biliary system.

Description from OMIM:48 147710

Aliases & Classifications for Intussusception

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 28ICD9CM, 59SNOMED-CT, 36MeSH, 48OMIM, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

intussusception 9 11 46 63
intussusception of intestine 9
invagination of intestine 9
intussusception nos 9
colon 9


External Ids:

Disease Ontology9 DOID:8446
ICD9CM28 560.0
MeSH36 D007443
OMIM48 147710
ICD1026 K56.1

Related Diseases for Intussusception

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Intussusception via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 240)
idRelated DiseaseScoreTop Affiliating Genes
1peutz-jeghers syndrome31.1STK11, APC
2intestinal obstruction30.5CFTR, ALB
3gastroenteritis30.3ZNF185
4pancreatitis30.3CFTR, IL6, ALB, CRP
5cholangitis30.2CFTR, ALB
6acute pancreatitis30.2CRP, IL6, CFTR
7colon cancer30.2CFTR, APC, STK11, CCND1
8cystic fibrosis30.1CFTR, F8, ALB
9peritonitis30.1IL6, ALB, CRP
10crohn's disease30.0ALB, CRP
11kaposi's sarcoma30.0IL6, F8
12burkitt's lymphoma30.0WAS, CCND1, IL6, F8, ALB, CD40LG
13deficiency anemia29.9IL6, ALB, CRP
14multiple myeloma29.8CCND1, IL6
15familial adenomatous polyposis29.8APC, STK11, CCND1
16acquired immunodeficiency syndrome29.7IL6, F8, ALB
17systemic lupus erythematosus29.7IL6, F8, CRP, CD40LG
18colorectal cancer29.7APC, STK11, CCND1
19lung cancer29.7STK11, CCND1, ALB
20sepsis29.7IL6, ALB, CRP
21diarrhea29.7CRP, ALB, ZNF185, CFTR
22myeloma29.6CCND1, IL6, ALB, CD40LG
23leukemia29.6CD40LG, F8, IL6, CCND1, CFTR
24meckel's diverticulum10.5
25lipoma10.5
26rectal prolapse10.5
27adenocarcinoma10.4
28duodenitis10.4
29gastroduodenitis10.4
30adenoma10.4
31gastrointestinal stromal tumor10.3
32intestinal atresia10.3
33melanoma10.3
34cystadenoma10.2
35lipomatosis10.2
36sarcoma10.2
37tuberculosis10.2
38gastric outlet obstruction10.2
39anisakiasis10.1
40appendicitis10.1
41celiac disease10.1
42ascending cholangitis10.1
43pneumatosis cystoides intestinalis10.1
44endometriosis10.1
45hodgkin's lymphoma10.1
46lymphangioma10.1
47purpura10.1
48inflammatory myofibroblastic tumor10.1
49jejunal atresia10.1
50cardiac tamponade10.1F8

Graphical network of the top 20 diseases related to Intussusception:



Diseases related to intussusception

Symptoms for Intussusception

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48OMIM
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Clinical features from OMIM:

147710

Drugs & Therapeutics for Intussusception

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Intussusception

Drug clinical trials:

Search ClinicalTrials for Intussusception

Search NIH Clinical Center for Intussusception

Search CenterWatch for Intussusception

Genetic Tests for Intussusception

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Anatomical Context for Intussusception

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34MalaCards
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MalaCards organs/tissues related to Intussusception:

34
Colon, Appendix, Small intestine, Pancreas, Lung, B cells, Breast, Liver, Endothelial, Skeletal muscle, Myeloid, Heart

Animal Models for Intussusception or affiliated genes

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Sources:
38MGI
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Publications for Intussusception

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Sources:
53PubMed
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Articles related to Intussusception:

(show top 50)    (show all 710)
idTitleAuthorsYear
1
Colo-colic intussusception secondary to lipomatous polyp in an adult. (23462651)
2013
2
Intussusception with complete twisting of mesenteric root after Roux-en-Y gastric bypass. (23522620)
2013
3
Aortic intussusception complicating diagnostic angiography: recognition and management. (23608257)
2013
4
Perspectives on intussusception. (23597529)
2013
5
Colonic intussusception caused by anisakiasis: a case report and review of the literature. (23318852)
2013
6
Jejunal intussusception and polyps with different types of malignant transformation in Peutz-Jeghers syndrome: Report of a case. (23255928)
2013
7
Appendicular intussusception with lymphoid hyperplasia. (23847834)
2013
8
Intussusception risk and disease prevention associated with rotavirus vaccines in Australia's National Immunization Program. (23964090)
2013
9
Management of intussusception in resource-limited settings. (23994003)
2013
10
Intussusception as a presenting feature of Burkitt lymphoma: implications for management and outcome. (21969235)
2012
11
Ileocolic intussusception due to a cecal endometriosis: case report and review of literature. (22676322)
2012
12
Antibiotics administration before enema reduction of intussusception: is it necessary? (22595575)
2012
13
Appendiceal intussusception to the cecum caused by mucocele of the appendix: Laparoscopic approach. (22706297)
2012
14
Japanese guidelines for the management of intussusception in children, 2011. (22748165)
2012
15
Prevalence of severe acute rotavirus gastroenteritis and intussusceptions in Ghanaian children under 5 years of age. (22337844)
2012
16
Sonographically guided enema for intussusception reduction: a safer alternative to fluoroscopy. (23011611)
2012
17
Strangulating ileocolic intussusception in pregnancy. (24293856)
2012
18
Intussusception: edematous ileocecal valve mimicking incomplete reduction. (22391932)
2012
19
The role of plain radiography in assessing intussusception with vascular compromise in children. (22291835)
2011
20
Intussusception: incidence and treatment-insights from the nationwide German surveillance. (21415671)
2011
21
Prolapsed sigmoid intussusception per anus in an elderly man: a case report. (21849068)
2011
22
Small bowel intussusception caused by a jejunal polyp in Peutz-Jeghers syndrome: a case treated with double balloon enteroscopy. (20658191)
2011
23
Laparoscopy-assisted hydrostatic in situ reduction of intussusception: A reasonable alternative? (21430840)
2011
24
Heterotopic gastric mucosa: a rare cause of jejunal intussusception. (21944611)
2011
25
Adenomyoma of the ileum leading to intussusception. (22110422)
2011
26
Intestinal spirochetosis as a causative factor for colocolic intussusception. (21274545)
2011
27
Incidence of intussusception in early infancy: a capture-recapture estimate for Germany. (21698555)
2011
28
Severe type of adult jejunal intussusception caused by long intestinal tube in a patient with intestinal obstruction due to cecal carcinoma. (22688937)
2011
29
Intussusception: an anatomical perspective with review of the literature. (21268121)
2011
30
Voluminous intussusception involving the whole midgut in a teenager: a unique differentiation from abdominal cocoon. (21512845)
2011
31
Multiple Small Bowel Intussusceptions Caused by Kaposi's Sarcoma: The Radiologist's Point of View. (21572620)
2011
32
Postoperative ileo-ileal intussusception following surgical resection of patent omphalomesenteric duct. (21484814)
2011
33
Paediatric intussusception caused by acquired immunodeficiency syndrome-associated Kaposi sarcoma. (20535484)
2010
34
A ganglioneuroma of the sigmoid colon presenting as leading point of intussusception in a child: a case report. (19159704)
2009
35
Contents of serum albumin after surgical operation in children with acute intussusception]. (19374811)
2009
36
HoxB5 induces endothelial sprouting in vitro and modifies intussusceptive angiogenesis in vivo involving angiopoietin-2. (19403561)
2009
37
Ileo-ileal intussusception due to inverted Meckel's diverticulum. (19803269)
2009
38
Massive mucinous cystadenoma of the appendix with intussusception in an adult: usefulness of reconstructed computed tomography images. (18301985)
2008
39
Intussusception mimicking rectal prolapse. (18327576)
2008
40
Multiple lipomatosis--a rare cause for small bowel intussusception. (18157202)
2007
41
Intussusception due to intestinal anisakiasis: a case report. (15160751)
2004
42
Delta-F508 cystic fibrosis mutation is not linked to intussusception: implications for rotavirus vaccine. (12969205)
2003
43
Laparoscopic reduction of an ileoileal intussusception and resection of an inverted Meckel's diverticulum in an adult. (12728389)
2003
44
Intestinal intussusception and occlusion caused by small bowel polyps in the Peutz-Jeghers syndrome. Management by combined intraoperative enteroscopy and resection through minimal enterostomy: case report. (11313662)
2000
45
Large-cell carcinoma of the lung. With major bleeding and intussusception. (1328355)
1992
46
Intussusception-type antireflux valve in the Roux-en-Y loop to prevent ascending cholangitis after hepatic portojejunostomy. (2313499)
1990
47
Small bowel obstruction by intussusception in a bladder diverticulum: complication of inguinal hernia repair. (3122870)
1987
48
Recurrent acute pancreatitis and intussusception complicating an intraluminal duodenal diverticulum. (6786954)
1981
49
Extramedullary plasmacytoma of the colon: a rare cause of intussusception. (889191)
1977
50
ACCESSORY PANCREAS WITH INTUSSUSCEPTION. (17863874)
1918

Variations for Intussusception

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Expression for genes affiliated with Intussusception

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Intussusception

Search GEO for disease gene expression data for Intussusception.

Pathways for genes affiliated with Intussusception

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Sources:
51PathCards, 39NCBI BioSystems Database, 5Cell Signaling Technology, 61Thomson Reuters, 54QIAGEN, 31KEGG, 13EMD Millipore
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Pathways related to Intussusception according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7CCND1, APC
2
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway61
9.6CRP, CCND1
39.4CRP, IL6
49.4APC, STK11, CCND1
59.4IL6, CCND1
69.4IL6, CCND1
7
Show member pathways
BCR signaling pathway39
TCR Signaling Pathway39
9.3CD40LG, IL6, WAS
8
Show member pathways
PLK2 and PLK4 events39
Polo-like kinase signaling events in the cell cycle39
9.1STK11, CCND1, IL6
9
Show member pathways
9.1CD40LG, IL6, CCND1
109.1APC, CCND1, IL6
119.1IL6, CCND1, APC
12
Show member pathways
thioredoxin pathway39
8.9CRP, ALB, IL6
138.9CRP, ALB, F8, CFTR

Compounds for genes affiliated with Intussusception

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Sources:
46Novoseek, 12DrugBank, 52PharmGKB, 30IUPHAR, 25HMDB, 62Tocris Bioscience
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Compounds related to Intussusception according to GeneCards/GeneDecks:

(show top 50)    (show all 130)
idCompoundScoreTop Affiliating Genes
1refacto4610.0ALB, F8
2kogenate469.9ALB, F8
3sandoglobulin469.8CD40LG, IL6
4gamma globulin469.7ALB, CD40LG, CRP
5tocilizumab46 1210.7CRP, IL6
6p00001469.7CRP, F8, CCND1
7turpentine469.6IL6, CRP
8pmma469.5CD40LG, CRP, IL6
9iron sucrose469.5IL6, CRP
10okt3469.5IL6, CRP, CD40LG
11sulindac46 1210.5CCND1, APC, ALB
12vitamin b12469.4ALB, CD40LG, CRP
13fenofibrate46 52 1211.4IL6, CRP, CD40LG
14polyethylene glycol469.3ALB, F8, CD40LG, CRP
15dextran sulfate469.3IL6, ALB, CD40LG
16rituximab46 52 1211.3CD40LG, CRP, F8, IL6
17rosuvastatin46 52 30 1212.2ALB, CRP, IL6
18citrate469.2CRP, CFTR, F8, ALB
19endotoxin469.2CD40LG, IL6, CRP, F8
20aspirin46 52 30 2512.2CD40LG, CRP, APC, CFTR, F8
21celecoxib46 62 30 52 25 1214.2CCND1, APC, ALB
22cdp571469.1CRP, IL6
23paraffin469.1CD40LG, APC, CFTR, STK11, CCND1
24ibuprofen46 30 52 25 1213.1ALB, IL6, CFTR
25ascorbic acid46 2510.0ALB, CFTR, CD40LG, CRP
26neopterin469.0IL6, CRP, CD40LG
27adenylate469.0CCND1, CD40LG, CFTR, APC, STK11
28curcumin469.0IL6, APC, CFTR, CCND1
29prednisolone46 30 1211.0F8, ALB, IL6, CRP
30epinephrine46 25 1210.9IL6, CD40LG, CFTR, F8, APC
31aspartate468.9CFTR, F8, ALB, CRP, CD40LG
32folate468.9CRP, APC, CCND1, ALB, CD40LG
33rosiglitazone30 46 52 25 1212.9CRP, ALB, CCND1, IL6
34rapamycin468.9CRP, CD40LG, CCND1, STK11, WAS, APC
35methotrexate52 46 1210.8CRP, IL6, ALB, CCND1
36ivig468.8IL6, ALB, CRP, CD40LG, F8
37n acetylcysteine468.7CD40LG, CFTR, CRP, CCND1, IL6
38indomethacin46 30 62 1211.7CD40LG, ALB, IL6, APC, CFTR
39fibrinogen468.7CD40LG, CRP, ALB, IL6, F8
40lactate468.7IL6, F8, ALB, CRP, CD40LG
41creatinine468.7ALB, F8, CRP, IL6, CD40LG
42vitamin d468.6APC, IL6, ALB, CFTR
43norepinephrine46 25 1210.6APC, F8, CD40LG, CFTR, IL6, CRP
44serine468.5F8, WAS, STK11, APC, CFTR, CD40LG
45vegf468.5STK11, CCND1, CRP, IL6, F8, CD40LG
46estrogen468.4CFTR, APC, CCND1, IL6, F8, CD40LG
47glucose468.3CRP, ALB, F8, IL6, STK11, APC
48lipid468.1F8, IL6, WAS, STK11, ALB, CRP
49alanine468.1CRP, CD40LG, ALB, F8, IL6, STK11
50testosterone46 62 25 1210.9CD40LG, ALB, IL6, CCND1, APC, CFTR

GO Terms for genes affiliated with Intussusception

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17Gene Ontology
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Cellular components related to Intussusception according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.6ALB, F8
2extracellular spaceGO:0056158.0CD40LG, CRP, ALB, F8, IL6

Biological processes related to Intussusception according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of epithelial cell proliferation involved in prostate gland developmentGO:06077010.0APC, STK11
2canonical Wnt signaling pathwayGO:0600709.6CCND1, STK11, APC
3muscle cell cellular homeostasisGO:0467169.6IL6, APC
4negative regulation of lipid storageGO:0108889.6IL6, CRP
5cellular response to DNA damage stimulusGO:0069749.4CCND1, STK11, APC
6acute-phase responseGO:0069539.3CRP, F8, IL6
7defense response to Gram-positive bacteriumGO:0508309.3IL6, CRP
8inflammatory responseGO:0069549.1CD40LG, CRP, IL6
9platelet activationGO:0301688.9IL6, F8, ALB, CD40LG
10response to drugGO:0424938.7IL6, CCND1, CFTR

Molecular functions related to Intussusception according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1enzyme bindingGO:0198999.1ALB, CCND1, CFTR
2protein bindingGO:0055156.6CRP, CFTR, APC, WAS, STK11, CCND1

Products for genes affiliated with Intussusception

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Intussusception

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet