Aliases & Classifications for Intussusception

MalaCards integrated aliases for Intussusception:

Name: Intussusception 12 29 52 42 14
Invagination of Intestine or Colon 12
Intussusception of Intestine 12
Intussusception Nos 12

Characteristics:

HPO:

32
intussusception:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

Disease Ontology 12 DOID:8446
ICD10 33 K56.1
ICD9CM 35 560.0
MeSH 42 D007443
NCIt 47 C113484
SNOMED-CT via HPO 65 263681008 35327006 49723003
UMLS 69 C0021933

Summaries for Intussusception

MalaCards based summary : Intussusception, also known as invagination of intestine or colon, is related to ileocolitis and lymphoma. An important gene associated with Intussusception is STK11 (Serine/Threonine Kinase 11), and among its related pathways/superpathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Vaccines and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and appendix, and related phenotypes are hematopoietic system and cardiovascular system

Related Diseases for Intussusception

Diseases related to Intussusception via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 381)
id Related Disease Score Top Affiliating Genes
1 ileocolitis 30.8 CD40LG CD79A
2 lymphoma 30.4 CD40LG CD79A IL6
3 leiomyosarcoma 29.3 CD40LG CD79A CRP
4 bladder diverticulum 29.2 CD40LG CD79A
5 kaposi sarcoma 28.8 CD40LG CD79A CRP IL6
6 systemic lupus erythematosus 28.6 CD40LG CD79A CRP IL6
7 thoraco abdominal enteric duplication 10.9
8 collagenopathy type 2 alpha 1 10.7 CRP IL6
9 crystal arthropathies 10.7 CRP IL6
10 shoulder impingement syndrome 10.7 CRP IL6
11 brachydactyly-distal symphalangism syndrome 10.7 CRP IL6
12 epstein-barr virus hepatitis 10.7 CRP IL6
13 x-linked dominant intellectual disability-epilepsy syndrome 10.7 CRP IL6
14 acquired polycythemia 10.7 CD40LG CRP
15 erythema elevatum diutinum 10.7 CRP IL6
16 cataract congenital autosomal dominant 10.7 CRP IL6
17 cannabis dependence 10.7 CD40LG CRP
18 chronic diarrhea due to guanylate cyclase 2c overactivity 10.7 CRP IL6
19 hypertensive heart disease 10.7 CD40LG CRP
20 malignant gastric granular cell tumor 10.7 CRP IL6
21 rocky mountain spotted fever 10.7 CD40LG CRP
22 beach ear 10.6 CD40LG CRP
23 nodular nonsuppurative panniculitis 10.6 CRP IL6
24 hemangioma of spleen 10.6 CRP IL6
25 lung occult large cell carcinoma 10.6 CRP IL6
26 cicatricial lagophthalmos 10.6 CRP IL6
27 multiple congenital anomalies mental retardation, growth failure and cleft lip palate 10.6 CRP IL6
28 vulvar sarcoma 10.6 CD40LG IL6
29 intracranial chondrosarcoma 10.6 CD79A CFTR
30 diphtheritic cystitis 10.5 CD79A CRP
31 islet cell tumor 10.5 CRP IL6
32 queensland tick typhus 10.5 CRP IL6
33 alcoholic neuropathy 10.5 CD40LG CD79A
34 calloso-genital dysplasia 10.5 CD40LG CD79A
35 variola major 10.5 CD40LG CD79A
36 mu chain disease 10.5 CD40LG CD79A
37 rabies 10.5 CD40LG CD79A
38 familial retinoblastoma 10.5 CD40LG CD79A
39 anti-basement membrane glomerulonephritis 10.5 CD40LG CD79A
40 microinvasive cervical squamous cell carcinoma 10.5 CD40LG CD79A
41 fetal erythroblastosis 10.5 CD40LG CD79A
42 spinal canal and spinal cord meningioma 10.5 CD40LG CD79A
43 trichostrongyloidiasis 10.5 CD40LG CD79A
44 leukodystrophy 10.5 CD40LG CD79A
45 retinal microaneurysm 10.5 CD40LG CD79A
46 heart septal defect 10.5 CD40LG CD79A
47 cryptorchidism arachnodactyly mental retardation 10.5 CD40LG CD79A
48 acute kidney tubular necrosis 10.5 CD40LG CD79A
49 secretory meningioma 10.5 CD40LG CD79A
50 hodgkin's lymphoma, nodular sclerosis 10.5 CD40LG CD79A

Graphical network of the top 20 diseases related to Intussusception:



Diseases related to Intussusception

Symptoms & Phenotypes for Intussusception

Human phenotypes related to Intussusception:

32
id Description HPO Frequency HPO Source Accession
1 intussusception 32 HP:0002576

MGI Mouse Phenotypes related to Intussusception:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.91 AIF1 CAMP CD40LG CD79A CFTR ENG
2 cardiovascular system MP:0005385 9.87 AIF1 CD40LG CRP ENG IL6 STK11
3 homeostasis/metabolism MP:0005376 9.81 TEK AIF1 CD40LG CD79A CFTR CRP
4 immune system MP:0005387 9.56 AIF1 CAMP CD40LG CD79A CFTR CRP
5 vision/eye MP:0005391 9.1 AIF1 CAMP CFTR IL6 STK11 TEK

Drugs & Therapeutics for Intussusception

Drugs for Intussusception (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 4,Phase 3,Phase 1,Phase 2
2 Pharmaceutical Solutions Phase 3
3 Citrate Nutraceutical Phase 3
4
Citric Acid Nutraceutical, Vet_approved Phase 3 77-92-9 311
5
Hydrocortisone Approved, Vet_approved 50-23-7 5754 657311
6
Butyric Acid Experimental 107-92-6 264
7 Hemostatics
8 Anti-Bacterial Agents
9 Antibiotics, Antitubercular
10 Anti-Inflammatory Agents
11 Cortisol succinate
12 Hydrocortisone 17-butyrate 21-propionate
13 Hydrocortisone acetate
14 Hydrocortisone-17-butyrate

Interventional clinical trials:

(show all 32)

id Name Status NCT ID Phase Drugs
1 RCT: STARR vs Biofeedback Completed NCT00556283 Phase 4
2 Study of Stapled Transanal Rectal Resection (STARR) Surgery in Refractory Constipation Associated With Obstructive Defecation Syndrome (ODS) Completed NCT00256984 Phase 4
3 Stapled Trans Anal Rectal Resection (STARR) for Outlet Obstruction: Functional and Morphological Outcome Completed NCT00521872 Phase 4
4 Potential Mechanisms for Intussusception After Rotavirus Vaccine-Pilot Study Active, not recruiting NCT02542462 Phase 4 Rotarix®,;Rotarix®, with other routine vaccines;RotaTeq®,;RotaTeq®, with other routine vaccines
5 Optimising Rotavirus Vaccine in Aboriginal Children Not yet recruiting NCT02941107 Phase 4 Rotarix (RV1);Placebo
6 A Phase III Clinical Trial to Evaluate the Protective Efficacy of Three Doses of Oral Rotavirus Vaccine (ORV) 116E Unknown status NCT01305109 Phase 3
7 A Study to Test 2 Doses of GSK Biologicals' Oral Live Attenuated Human Rotavirus (HRV) Vaccine in Healthy Infants Completed NCT00197210 Phase 3
8 A Study to Test 2 Doses of the HRV Vaccine in Healthy Infants. Completed NCT00140673 Phase 3
9 Long-term Efficacy and Safety of Subjects Approximately 3 Years After Priming With 2 Doses of GSK Bio's HRV Vaccine. Completed NCT00420316 Phase 3
10 Rotavirus Efficacy and Safety Trial (REST)(V260-006) Completed NCT00090233 Phase 3
11 A Study of the Immunogenicity, Tolerability, and Safety of a New Formulation of RotaTeq™ in Infants (V260-035) Completed NCT01600092 Phase 3
12 Efficacy, Safety, and Immunogenicity of V260 in Healthy Chinese Infants (V260-024) Completed NCT02062385 Phase 3
13 Efficacy and Safety of a Pentavalent Rotavirus Vaccine (BRV-PV) Against Severe Rotavirus Gastroenteritis in Niger Recruiting NCT02145000 Phase 3
14 Dose Escalation Study to Evaluate Oral Rotavirus Vaccine 116E Live Attenuated in Healthy Infants 8 to 20 Weeks Old Unknown status NCT00439660 Phase 1, Phase 2
15 Safety and Immunogenicity of Rotavirus Vaccine (RotaTeq(R)) in Infants With Short Bowel Syndrome Completed NCT00767364 Phase 1
16 Surgical Treatment of Obstructed Defecation Syndrome Unknown status NCT01899209
17 Evaluation of Universal Rotavirus Vaccination Program Unknown status NCT01273077
18 Study to Assess the Incidence of Intussusception in Children < 2 Years of Age in Singapore Completed NCT01177839
19 Intussusception Surveillance After Rotarix Introduction in Mexico Completed NCT00595205
20 Study on the Incidence of Intussusception (IS) in Children Aged < 12 Months in Japan Completed NCT01479491
21 Implementing Hospital-based Active Surveillance Procedures for Vaccine Safety Monitoring at IMSS Hospitals in Mexico Completed NCT00436358
22 Stapled TransAnal Rectal Resection (STARR) With Contour® TranstarTM Completed NCT00673400
23 Children's Surgery in Sub-Saharan Africa Completed NCT03185637
24 Special Drug Use Investigation for ROTARIX® Completed NCT01636739
25 Drug Use Investigation for ROTARIX® Completed NCT01636193
26 Long Term Results of STARR With Contour Transtar Completed NCT02971332
27 Safety Study of GSK Biologicals' Rotavirus Vaccine (Rotarix®) Administered to Children Aged <1 Year in the United States Completed NCT00875641
28 Obstructed Defaecation: Proctography Versus Ultrasound in Symptomatic Patients Completed NCT02239302
29 Gastric Plication in Mexican Patients Completed NCT03210207
30 Effect of Hydrocortisone on Improving Outcome of Pneumatic Reduction of Infantile Intussusception Recruiting NCT02691858 Hydrocortisone;Saline
31 Correlation of Anal Acoustic Reflectometry Parameters With Degree of Rectal Intussusception and Prolapse Recruiting NCT02774798
32 Does the Stapled Transanal Rectal Resection (STARR Procedure) Has an Effect on Anal Compliance ? Recruiting NCT02052063

Search NIH Clinical Center for Intussusception

Cochrane evidence based reviews: intussusception

Genetic Tests for Intussusception

Genetic tests related to Intussusception:

id Genetic test Affiliating Genes
1 Intussusception 29

Anatomical Context for Intussusception

MalaCards organs/tissues related to Intussusception:

39
Colon, Small Intestine, Appendix, Pancreas, Testes, Lung, B Cells

Publications for Intussusception

Articles related to Intussusception:

(show top 50) (show all 909)
id Title Authors Year
1
A rare cause of recurrent acute pancreatitis: duodenum intussusception by a fenestrated duodenal web. ( 28342893 )
2017
2
Unusual ultrasound appearance of small bowel intussusception and secondary bowel obstruction in a child with Peutz-Jeghers syndrome. ( 28314199 )
2017
3
Intussusception caused by heterotopic gastric mucosa in small intestine: a case report. ( 28893301 )
2017
4
Incidence of acute intussusception among infants in eastern France: results of the EPIstudy trial. ( 28058530 )
2017
5
Small Bowel Intussusception in a 16-Month-Old Child With Peutz-Jeghers Syndrome. ( 28929791 )
2017
6
Epidemiology of childhood intussusception in Bangladesh: Findings from an active national hospital based surveillance system, 2012-2016. ( 28941622 )
2017
7
Submucosal Colonic Lipoblastoma Presenting With Colo-colonic Intussusception in an Infant. ( 28420321 )
2017
8
Triple site intussusceptions in Peutz-Jeghers syndrome. ( 28768368 )
2017
9
Implementing ultrasound-guided hydrostatic reduction of intussusception in a low-resource country in Sub-Saharan Africa: our initial experience in Ethiopia. ( 28840373 )
2017
10
Say What? Bannayan-Riley-Ruvalcaba Syndrome Presenting with Gastrointestinal Bleeding Due to Hamartoma-Induced Intussusception. ( 28168574 )
2017
11
Burkitt lymphoma as a lead point for jejunojejunal intussusception in a human immunodeficiency virus patient. ( 28523628 )
2017
12
An intestinal carcinoid causing transient jejunal intussusception in an adult-A case report. ( 28092782 )
2017
13
Rectal axis and enterocele on proctogram may predict laparoscopic ventral mesh rectopexy outcomes for rectal intussusception. ( 28674947 )
2017
14
Perforated Meckel's Diverticulum causing Intussusception in a Neonate. ( 28920033 )
2017
15
Intussusception in Premature Baby: Unusual Cause of Bowel Obstruction and Perforation. ( 28083499 )
2017
16
Unparalleled patterns of intussusception and rotavirus gastroenteritis hospitalization rates among children younger than six years in Italy. ( 28067936 )
2017
17
Incidentally Detected Small Intestine Intussusception Caused by Primary Small Intestine Carcinoma on (18)F-FDG PET/CT. ( 28878855 )
2017
18
Rare diagnosis of intestinal lipomatosis complicated by intussusception in an adult: A case report. ( 28898799 )
2017
19
Sporadic Jejunal Lateral Spreading Tumor: A Rare Cause of Recurrent Jejunojejunal Intussusception. ( 28848802 )
2017
20
Intussusception in a preterm newborn. ( 28899633 )
2017
21
Antegrade jejunojejunal intussusception inside a retrograde jejunogastric intussusception (double intussusception)-A rare case report. ( 28881334 )
2017
22
A randomized trial of pneumatic reduction versus hydrostatic reduction for intussusception in pediatric patients. ( 28827051 )
2017
23
Effects of esketamine sedation compared to morphine analgesia on hydrostatic reduction of intussusception: A case-cohort comparison study. ( 28940868 )
2017
24
Epidemiological Correlation between Fecal Adenovirus Subgroups and Pediatric Intussusception in Korea. ( 28875609 )
2017
25
A case of small intestinal intussusception caused by anisakiasis diagnosed and treated by upper gastrointestinal endoscopy. ( 28781357 )
2017
26
Antegrade jejunogastric intussusception and common bile duct stones at 14 months after gastrectomy and cholecystectomy: A case report. ( 28846944 )
2017
27
Intussusception of the bowel in adults: two different cases. ( 28944338 )
2017
28
Gastroduodenojejunal Intussusception: A Very Rare Complication of a Pedunculated Gastric Harmatomatous Giant Polyp. ( 28050044 )
2017
29
Laparoscopic ventral rectopexy for rectal prolapse and rectal intussusception using a biological mesh. ( 28371010 )
2017
30
Point-of-Care Ultrasound Could Streamline the Emergency Department Workflow of Clinically Nonspecific Intussusception. ( 28926507 )
2017
31
BRUNNER GLAND ADENOMA MASQUERADING AS DUODENAL GASTROINTESTINAL STROMAL TUMOR WITH INTUSSUSCEPTION: CASE REPORT. ( 28489176 )
2017
32
A Clinical Scoring System to Predict the Clinical Sequelae of Computed Tomography Diagnosed Intussusception. ( 28916884 )
2017
33
Rare cause of colonic intussusception in an adult. ( 28918406 )
2017
34
Protein-losing Enteropathy Caused by Spontaneous Reduction of Intussusception with Meckel's Diverticulum. ( 28413865 )
2017
35
Hospitalization rates for intussusception in children aged 0-59A months from 2009 to 2014 in Italy. ( 28075671 )
2017
36
The Role of Laparoscopy in the Management of a Diagnostic Dilemma: Jejunal Ectopic Pancreas Developing into Jejunojejunal Intussusception. ( 28819577 )
2017
37
Dacron Graft Intussusception Technique for Treatment of Type A Aortic Dissections: Technical Notes and Preliminary Results. ( 27556309 )
2016
38
Successful endoscopic submucosal dissection of a rectal laterally spreading tumor causing intussusception. ( 27102831 )
2016
39
Risk of Intussusception with Rotavirus Vaccine. ( 27641974 )
2016
40
Ileo-colic intussusception by ileo-cecal valve lipoma - an infrequent ultrasonographic occurrence. A case report. ( 27622418 )
2016
41
Inverted Meckel's Diverticulum with Intussusception and Ulceration Diagnosed after Rectal Double-Balloon Enteroscopy. ( 28008404 )
2016
42
Intussusception in Children Aged Less than Five years. ( 27211600 )
2016
43
Trapped among the waves: massive jejunojejunal intussusception after gastric bypass. ( 27154782 )
2016
44
Colonoscopic reduction of colo-colic intussusception in an adult with immunoglobulin A vasculitis (Henoch-SchAPnlein purpura). ( 26418752 )
2016
45
Enteric duplication cyst as a leading point for ileoileal intussusception in an adult: A rare cause of complete small intestinal obstruction. ( 27358681 )
2016
46
Intussusception and perforation due to an inflammatory fibroid polyp located in the ileum. ( 27637204 )
2016
47
Prognostic indicators for failed nonsurgical reduction of intussusception. ( 27563245 )
2016
48
Adult Intussusception Caused by Inverted Meckel's Diverticulum Containing Mesenteric Heterotopic Pancreas and Smooth Muscle Bundles. ( 27498547 )
2016
49
A case of small bowel metastasis from spinal Ewing sarcoma causing intussusception in an adult female. ( 27083867 )
2016
50
Rotavirus Vaccine and Intussusception Hospitalizations. ( 27558937 )
2016

Variations for Intussusception

Expression for Intussusception

Search GEO for disease gene expression data for Intussusception.

Pathways for Intussusception

Pathways related to Intussusception according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.2 CD79A ENG IL6
2 10.78 CD79A ENG IL6
3 10.43 CRP IL6

GO Terms for Intussusception

Cellular components related to Intussusception according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.92 CD40LG CD79A ENG IL6

Biological processes related to Intussusception according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.73 AIF1 CD40LG IL6 TEK
2 inflammatory response GO:0006954 9.62 AIF1 CD40LG CRP IL6
3 positive regulation of protein phosphorylation GO:0001934 9.54 AIF1 ENG TEK
4 response to electrical stimulus GO:0051602 9.46 AIF1 IL6
5 positive regulation of angiogenesis GO:0045766 9.43 CAMP ENG TEK
6 sprouting angiogenesis GO:0002040 9.4 ENG TEK
7 defense response to Gram-positive bacterium GO:0050830 9.33 CAMP CRP IL6
8 negative regulation of lipid storage GO:0010888 8.96 CRP IL6
9 positive regulation of T cell proliferation GO:0042102 8.8 AIF1 CD40LG IL6

Sources for Intussusception

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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