COLON
MCID: INT051
MIFTS: 59

Intussusception (COLON) malady

Gastrointestinal diseases category

Summaries for Intussusception

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46OMIM, 32MalaCards
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MalaCards: Intussusception, also known as intussusception of intestine, is related to ulcerative colitis and inflammatory bowel disease. An important gene associated with Intussusception is STK11 (serine/threonine kinase 11), and among its related pathways are Immune response Oncostatin M signaling via JAK-Stat in human cells and Platelet degranulation . The compounds estrogen and gamma globulin have been mentioned in the context of this disorder. Affiliated tissues include colon, appendix and small intestine, and related mouse phenotypes are renal/urinary system and vision/eye.

Description from OMIM:46 147710

Aliases & Classifications for Intussusception

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 46OMIM, 34MeSH, 56SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

intussusception 8 10 44 60
intussusception of intestine 8
invagination of intestine 8
intussusception nos 8
colon 8


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Disease Ontology8 DOID:8446
OMIM46 147710
MeSH34 D007443
ICD9CM27 560.0
ICD1025 K56.1

Related Diseases for Intussusception

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Intussusception via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1043)
idRelated DiseaseScoreTop Affiliating Genes
1ulcerative colitis31.1CFTR, IL6, CRP, APC
2inflammatory bowel disease30.9IL6
3peutz-jeghers syndrome30.9APC, STK11
4breast cancer30.9CCND1, STK11, VEGFA, ANGPT2, CYR61
5vascular cancer30.8F8
6adenocarcinoma30.5CCND1, APC, STK11, VEGFA, ANGPT2, CYR61
7pneumonia30.4CRP, IL6, CFTR
8adenoma30.4ANGPT2, STK11, APC, CCND1
9prostate cancer30.4CCND1, APC, VEGFA, ANGPT2, CYR61, IL6
10pancreatic cancer30.4CCND1, STK11, VEGFA, CFTR
11aortic aneurysm30.4CRP
12hepatocellular carcinoma30.4CCND1, APC, F8, STK11, VEGFA, ANGPT2
13ovarian cancer30.4ANGPT2, VEGFA, CCND1
14bacteriuria30.3CRP
15melanoma30.3CCND1, STK11, VEGFA, ANGPT2, CYR61, CFTR
16amyloidosis30.3ALB, CRP
17pancreatitis30.3ALB, CFTR, IL6, CRP
18atopic dermatitis30.2FLG2
19hepatitis a30.2F8
20acromegaly30.2APC
21esophageal cancer30.2CCND1
22neuropathy30.2ALB
23sarcoma30.2F8, ANGPT2
24tuberculosis30.2CRP, ALB
25thyroid cancer30.1ANGPT2, APC, CCND1
26appendicitis30.1CRP
27cholangitis30.1ALB, CFTR
28cystic fibrosis30.1ALB, CFTR, F8
29acute pancreatitis30.1CRP, IL6, CFTR
30colon cancer30.1CCND1, APC, STK11, VEGFA, CFTR
31endometriosis30.1IL6, CYR61, ANGPT2, VEGFA
32burkitt's lymphoma30.1ALB, IL6, CD40LG, F8, WAS, CCND1
33hypercalcemia30.1ALB
34juvenile polyposis syndrome30.1STK11, APC
35angiosarcoma30.0ANGPT2
36bronchiectasis30.0CFTR
37gastroenteritis30.0ZNF185, PPT2
38hepatitis30.0CD40LG, F8
39plasmacytoma30.0IL6
40chorioamnionitis30.0IL6, CRP
41endometrial carcinoma30.0CCND1, VEGFA, ANGPT2, CYR61
42obesity30.0CRP, IL6
43peritonitis30.0CRP, IL6, ALB
44diabetes mellitus30.0F8, CRP, VEGFA, ANGPT2, CD40LG, IL6
45asthma30.0ANGPT2
46pyelonephritis30.0CRP
47arthritis29.9ALB, IL6, CRP
48kidney cancer29.9VEGFA
49papillary thyroid carcinoma29.9CCND1, APC, ANGPT2
50hypertension29.9CRP, ALB

Graphical network of the top 20 diseases related to Intussusception:



Diseases related to intussusception

Clinical Features for Intussusception

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46OMIM
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Clinical features from OMIM:

147710

Drugs & Therapeutics for Intussusception

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Intussusception

Search CenterWatch for Intussusception

Genetic Tests for Intussusception

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Anatomical Context for Intussusception

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32MalaCards
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MalaCards organs/tissues related to Intussusception:

32
Colon, Appendix, Small intestine, Pancreas, Lung, B cells, Breast, Liver, Endothelial, Skeletal muscle, Myeloid, Heart

Animal Models for Intussusception or affiliated genes

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36MGI
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Publications for Intussusception

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50PubMed
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Articles related to Intussusception:

(show top 50)    (show all 715)
idTitleAuthorsYear
1
Sigmoid malignancy presenting as recto-sigmoid intussusception. (24165414)
2013
2
ALK-positive large B-cell lymphoma presenting with jejunal intussusception. (23171433)
2013
3
Clinical outcomes following bowel resection versus reduction of intussusception. (23611718)
2013
4
Pediatric postoperative intussusception in the minimally invasive surgery era: a 13-year, single center experience. (23571141)
2013
5
Recurrent intussusception. (23736072)
2013
6
Unusual intussusception within a hiatal hernia sac, reduced endoscopically. (23582533)
2013
7
Interhospital transport of children with confirmed or suspected intussusception: experience at the New South Wales newborn and paediatric emergency transport service over 10 years. (24168884)
2013
8
Validation of diagnostic codes for intussusception and quantification of childhood intussusception incidence in Ontario, Canada: a population-based study. (23809052)
2013
9
Retrograde colon intussusception in an adult due to adenoma: treatment by combined laparoscopic and endoscopic approach. (24308592)
2013
10
Peutz-Jeghers syndrome complicated with intussusception: enteroscopic polyps resections through laparotomy. (23697287)
2013
11
Intussusception as a presenting feature of Burkitt lymphoma: implications for management and outcome. (21969235)
2012
12
Ileocolic intussusception due to a cecal endometriosis: case report and review of literature. (22676322)
2012
13
Potential intussusception risk versus health benefits from rotavirus vaccination in Latin America. (22431803)
2012
14
Trends in intussusception-associated deaths among US infants from 1979-2007. (21925681)
2012
15
Duodenal intussusception due to a giant neuroendocrine carcinoma in a patient with Peutz-Jeghers syndrome: case report and systematic review. (22356785)
2012
16
Workshop on intussusception in African countries--meeting report. (22520130)
2012
17
Small Intestinal Obstruction with Intussusception due to Acute Myeloid Leukemia: A Case Report. (22928122)
2012
18
Intussusception after laparoscopic gastric bypass surgery: an underrecognized complication. (22991661)
2012
19
Gastrointestinal stromal tumour presenting as gastroduodenal intussusception. (22927285)
2012
20
Postmarketing surveillance of intussusception following mass introduction of the attenuated human rotavirus vaccine in Mexico. (22695189)
2012
21
Neglected intussusception presenting as transanal prolapse of small bowel. (22323102)
2012
22
Acute pancreatitis secondary to duodenoduodenal intussusception in duodenal adenoma. (22679401)
2012
23
Ileoileal intussusception secondary to an ileal fibroma. (23275765)
2012
24
Mucinous adenocarcinoma of the appendix presenting as intussusception in 27 year old female. (23205315)
2012
25
Intussusception: an anatomical perspective with review of the literature. (21268121)
2011
26
An infant with intussusception. (22206138)
2011
27
Gastrointestinal stromal tumour presenting acutely as gastroduodenal intussusception. (22191138)
2011
28
Splenogonadal fusion: exceptional association with Moebius syndrome and intestinal intussusception. (21345046)
2011
29
Endoscopic reduction of a jejunogastric intussusception. (21287456)
2011
30
Extremely localized aortic dissection and intussusception of the intimal flap into the left ventricle. (21881338)
2011
31
Endoscopic diagnosis of a pylorogastric intussusception with spontaneous resolution. (22058364)
2011
32
Colocolonic intussusception with a leading point. (21070875)
2011
33
Acute adult intussusception caused by primary cecal non Hodgkin lymphoma. (22103053)
2011
34
Luminal view of an intussusception captured by capsule endoscopy. (21788752)
2011
35
Nephrectomy plus endoscopy-assisted intussusception ureterectomy for patients with renal pelvic cancer: long-term oncologic outcomes in comparison with nephroureterectomy plus bladder cuff removal. (21434766)
2011
36
Paediatric intussusception caused by acquired immunodeficiency syndrome-associated Kaposi sarcoma. (20535484)
2010
37
FDG PET/CT detection of intussusception caused by aggressive fibromatosis. (20395719)
2010
38
Prolapse of Intussusception through the Anus as a Result of Sigmoid Colon Cancer. (21060698)
2010
39
Clinical challenges and images in GI. Peutz-Jeghers syndrome with gastroduodenal intussusception secondary to gastric cancer. (19167388)
2009
40
Intestinal intussusception due to a pyogenic granuloma. (19227429)
2008
41
Intussusception and bleeding of a Meckel's diverticulum diagnosed by colonoscopy. (17173915)
2007
42
Ileoileal intussusception due to an inverted Meckel's diverticulum in a child. (18074745)
2007
43
Recombinant human erythropoietin induces intussusceptive microvascular growth in vivo. (14671634)
2004
44
Gastroduodenal intussusception due to Peutz-Jeghers syndrome in infancy. (11956792)
2002
45
Defaeco-peritoneography in the diagnosis of rectal intussusception and rectal prolapse. (9240681)
1997
46
Intussusceptive microvascular growth in a human colon adenocarcinoma xenograft: a novel mechanism of tumor angiogenesis. (8778579)
1996
47
Retrograde intussusception as a complication of Roux-en-Y anastomosis for choledochal cyst--report of one case. (7831989)
1994
48
Intussusception-type antireflux valve in the Roux-en-Y loop to prevent ascending cholangitis after hepatic portojejunostomy. (2313499)
1990
49
Histological study of intestinal atresia due to intrauterine intussusception. (6730716)
1984
50
Extramedullary plasmacytoma of the colon: a rare cause of intussusception. (889191)
1977

Genetic Variations for Intussusception

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Expression for genes affiliated with Intussusception

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Intussusception

Search GEO for disease gene expression data for Intussusception.

Pathways for genes affiliated with Intussusception

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53Reactome, 12EMD Millipore, 37NCBI BioSystems Database, 29KEGG
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Pathways related to Intussusception according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Immune response Oncostatin M signaling via JAK-Stat in human cells
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9.5IL6, VEGFA, CCND1
2
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9.5ALB, VEGFA, F8
39.4VEGFA, STK11, APC, CCND1
49.4ALB, IL6, CRP
59.2VEGFA, ANGPT2, EPO, IL6
69.2ALB, CFTR, CRP, F8
79.1CCND1, APC, CYR61
88.8CCND1, STK11, VEGFA, ANGPT2, EPO, IL6

Compounds for genes affiliated with Intussusception

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44Novoseek, 28IUPHAR, 59Tocris Bioscience, 11DrugBank, 24HMDB, 49PharmGKB
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Compounds related to Intussusception according to GeneCards/GeneDecks:

(show top 50)    (show all 106)
idCompoundScoreTop Affiliating Genes
1estrogen4410.7F8
2gamma globulin4410.6CRP
3pge24410.5VEGFA
4triamcinolone acetonide44 2811.1EPO, CFTR
5indomethacin44 59 28 1113.1APC, CFTR
6ivig4410.1CD40LG, CRP, F8
7norepinephrine44 11 2412.1APC, F8, CFTR
8citrate phosphate dextrose4410.1F8, EPO
9epinephrine44 11 2412.0F8, CD40LG, CFTR
10tween 80449.9ALB, EPO, F8
11refacto449.9F8, ALB
12iron sucrose449.9CRP, EPO, IL6
13phenylbutyrate449.9CCND1, EPO, CFTR
14cyclosporin a44 28 5911.9CFTR, CD40LG, ANGPT2, F8
15bucillamine449.8CRP, VEGFA, IL6
16rosiglitazone44 49 28 11 2413.8IL6, CCND1
17progestin449.7CCND1, F8, VEGFA, ANGPT2
18pmma449.7IL6, CD40LG, CRP
19heparin44 28 11 2412.7APC, F8, VEGFA, CD40LG
20rituximab44 49 1111.7F8, CRP, CD40LG, IL6
21polysulfone449.7EPO, ALB
22perindopril44 49 1111.6CRP, VEGFA, ALB
23aspartate449.6ALB, CFTR, CD40LG, F8
24infliximab44 49 1111.6CRP, VEGFA, ANGPT2, IL6
25bortezomib44 1110.6CCND1, VEGFA, CD40LG, IL6
26polyethylene glycol449.6ALB, CD40LG, CRP, F8
27vitamin b12449.6ALB, EPO, CD40LG, CRP
28aspirin44 49 28 2412.5APC, F8, CRP, CD40LG, CFTR
29creatinine449.4F8, CRP, ANGPT2, EPO, ALB
30thalidomide44 49 59 1112.4CCND1, VEGFA, CD40LG, EPO, IL6
31ascorbic acid44 2410.4ALB, CFTR, EPO, CRP
32curcumin449.3CCND1, APC, VEGFA, IL6, CFTR
33atorvastatin44 49 28 11 2413.2IL6, CD40LG, VEGFA, CRP
34methotrexate44 49 1111.2CCND1, CRP, EPO, IL6, ALB
35celecoxib44 59 28 49 11 2414.1CCND1, APC, VEGFA, ANGPT2, EPO, ALB
36paraffin449.1CCND1, APC, STK11, VEGFA, ANGPT2, CD40LG
37fibrinogen449.1F8, CRP, ANGPT2, CD40LG, IL6, ALB
38n acetylcysteine449.1CFTR, IL6, CD40LG, VEGFA, CRP, CCND1
39ly294002449.1CCND1, CRP, VEGFA, ANGPT2, EPO, IL6
40lactate448.9F8, CRP, CD40LG, EPO, IL6, ALB
41vitamin d448.9APC, EPO, IL6, CFTR, ALB
42prostacyclin448.9APC, F8, CRP, VEGFA, CYR61
43prednisolone44 28 1110.8ALB, IL6, CRP, F8
44rapamycin448.8CCND1, APC, WAS, CRP, STK11, VEGFA
45alanine448.7F8, CRP, STK11, CD40LG, IL6, CFTR
46testosterone44 59 11 2411.5CCND1, APC, CRP, CD40LG, EPO, IL6
47folate448.3CCND1, APC, CRP, CD40LG, EPO, CYR61
48lipid447.9APC, WAS, F8, CRP, STK11, CYR61
49tyrosine447.7CCND1, APC, WAS, F8, VEGFA, ANGPT2
50vegf447.6IL6, CCND1, F8, CRP, STK11, VEGFA

GO Terms for genes affiliated with Intussusception

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16Gene Ontology
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Cellular components related to Intussusception according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.5ALB, VEGFA, F8
2extracellular spaceGO:0056157.9ALB, F8, CRP, VEGFA, ANGPT2, CD40LG
3extracellular regionGO:0055766.9F8, CRP, PRB3, VEGFA, ANGPT2, EPO

Biological processes related to Intussusception according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of epithelial cell proliferation involved in prostate gland developmentGO:06077010.2APC, STK11
2negative regulation of lipid storageGO:0108889.9CRP, IL6
3canonical Wnt receptor signaling pathwayGO:0600709.8STK11, APC, CCND1
4response to estrogen stimulusGO:0436279.8CFTR, EPO, CCND1
5acute-phase responseGO:0069539.8F8, CRP, IL6
6positive regulation of focal adhesion assemblyGO:0518949.6EPB41L5, VEGFA
7platelet degranulationGO:0025769.5F8, VEGFA, ALB
8blood coagulationGO:0075969.2WAS, F8, VEGFA, ANGPT2, ALB
9agingGO:0075689.2IL6, EPO, CRP
10platelet activationGO:0301689.1ALB, IL6, CD40LG, VEGFA, F8
11positive regulation of protein phosphorylationGO:0019348.9CYR61, VEGFA, CCND1
12negative regulation of apoptotic processGO:0430668.3APC, VEGFA, CD40LG, CYR61, IL6, ALB

Products for genes affiliated with Intussusception

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Sources for Intussusception

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet