MCID: INT051
MIFTS: 53

Intussusception malady

Gastrointestinal diseases, Cancer diseases categories

Aliases & Classifications for Intussusception

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 3CDC, 60UMLS, 55SNOMED-CT, 27ICD9CM, 33MeSH, 25ICD10
See all sources

Intussusception, Aliases & Descriptions:

Name: Intussusception 9 11 43 60
Colon 9 3
Intussusception of Intestine 9
 
Invagination of Intestine 9
Intussusception Nos 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Gastrointestinal diseases


External Ids:

Disease Ontology9 DOID:8446
ICD9CM27 560.0
MeSH33 D007443
ICD1025 K56.1

Summaries for Intussusception

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CDC:3 Of cancers affecting both men and women, colorectal cancer (cancer of the colon and rectum) is the second leading cancer killer in the United States, but it doesn’t have to be. Screening can find precancerous polyps—abnormal growths in the colon or rectum—so they can be removed before turning into cancer. Screening also helps find colorectal cancer at an early stage, when treatment often leads to a cure.

MalaCards based summary: Intussusception, also known as colon, is related to peutz-jeghers syndrome and gastroenteritis, and has symptoms including autosomal dominant inheritanceand intussusception. An important gene associated with Intussusception is STK11 (serine/threonine kinase 11), and among its related pathways are Presenilin action in Notch and Wnt signaling and Jak/Stat Pathway. The compounds refacto and kogenate have been mentioned in the context of this disorder. Affiliated tissues include colon, appendix and small intestine, and related mouse phenotypes are reproductive system and liver/biliary system.

Related Diseases for Intussusception

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Diseases related to Intussusception via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 245)
idRelated DiseaseScoreTop Affiliating Genes
1peutz-jeghers syndrome31.5APC, STK11
2gastroenteritis30.8ZNF185
3intestinal obstruction30.5CFTR, ALB
4cholangitis30.3ALB, CFTR
5acute pancreatitis30.3CRP, IL6, CFTR
6polyposis, juvenile intestinal30.3APC, STK11
7cystic fibrosis30.0CFTR, F8, ALB
8multiple myeloma30.0CCND1, IL6
9pancreatitis29.9ALB, IL6, CRP, CFTR
10peritonitis29.9ALB, CRP, IL6
11crohn's disease29.9ALB, CRP
12deficiency anemia29.7CRP, ALB, IL6
13acquired immunodeficiency syndrome29.7F8, ALB, IL6
14systemic lupus erythematosus29.6CRP, CD40LG, F8, IL6
15colorectal cancer29.5APC, CCND1, STK11
16lung cancer29.5CCND1, ALB, STK11
17diarrhea29.4ALB, ZNF185, CFTR, CRP
18myeloma29.3CCND1, IL6, ALB, CD40LG
19burkitt lymphoma29.2WAS, F8, CD40LG, CCND1, IL6, ALB
20ileocolitis10.7
21lipoma10.6
22meckel's diverticulum10.6
23cardiac tamponade10.5F8
24rectal prolapse10.5
25schnitzler syndrome10.5CD40LG
26hemorrhagic fever10.5CD40LG
27scrub typhus10.5CD40LG
28hepatitis a10.5F8
29thrombophlebitis10.5F8
30adenocarcinoma10.5
31bacteriuria10.5CRP
32pyelonephritis10.4CRP
33aortic aneurysm10.4CRP
34duodenitis10.4
35gastroduodenitis10.4
36adenoma10.4
37primary immunodeficiency disease10.4CD40LG, WAS
38viral hepatitis10.3F8
39gastrointestinal stromal tumor10.3
40intestinal atresia10.3
41melanoma10.3
42vascular disease10.3F8, IL6
43antiphospholipid syndrome10.3CD40LG, F8
44cystadenoma10.2
45inflammatory myofibroblastic tumor10.2
46appendicitis10.2
47lipomatosis10.2
48malaria10.2ALB
49waldenstrom macroglobulinemia10.2CCND1, CD40LG
50spondyloarthropathy 110.2CRP, CD40LG

Graphical network of the top 20 diseases related to Intussusception:



Diseases related to intussusception

Symptoms for Intussusception

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HPO human phenotypes related to Intussusception:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 intussusception HP:0002576

Drugs & Therapeutics for Intussusception

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Drug clinical trials:

Search ClinicalTrials for Intussusception

Search NIH Clinical Center for Intussusception

Genetic Tests for Intussusception

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Anatomical Context for Intussusception

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MalaCards organs/tissues related to Intussusception:

31
Colon, Appendix, Small intestine, Pancreas, Lung, B cells, Breast, Liver, Endothelial, Heart, Skeletal muscle

Animal Models for Intussusception or affiliated genes

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Publications for Intussusception

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Articles related to Intussusception:

(show top 50)    (show all 763)
idTitleAuthorsYear
1
Rare case of adult jejunojejunal intussusception secondary to angiolipoma. (25883255)
2015
2
Jejunojejunal Intussusception. (25858341)
2015
3
Adenomyoma of the small intestine a rare pathological lead point for intussusception in an infant. (25392787)
2014
4
Jejunojejunal intussusception secondary to submucosal lipoma resulting in a 5-year history of intermittent abdominal pain. (25355752)
2014
5
Colo-colic intussusception secondary to lipomatous polyp in an adult. (23462651)
2013
6
Intussusception with complete twisting of mesenteric root after Roux-en-Y gastric bypass. (23522620)
2013
7
Aortic intussusception complicating diagnostic angiography: recognition and management. (23608257)
2013
8
Perspectives on intussusception. (23597529)
2013
9
Colonic intussusception caused by anisakiasis: a case report and review of the literature. (23318852)
2013
10
Jejunal intussusception and polyps with different types of malignant transformation in Peutz-Jeghers syndrome: Report of a case. (23255928)
2013
11
Appendicular intussusception with lymphoid hyperplasia. (23847834)
2013
12
Intussusception risk and disease prevention associated with rotavirus vaccines in Australia's National Immunization Program. (23964090)
2013
13
Management of intussusception in resource-limited settings. (23994003)
2013
14
Intussusception as a presenting feature of Burkitt lymphoma: implications for management and outcome. (21969235)
2012
15
Ileocolic intussusception due to a cecal endometriosis: case report and review of literature. (22676322)
2012
16
Antibiotics administration before enema reduction of intussusception: is it necessary? (22595575)
2012
17
Appendiceal intussusception to the cecum caused by mucocele of the appendix: Laparoscopic approach. (22706297)
2012
18
Japanese guidelines for the management of intussusception in children, 2011. (22748165)
2012
19
Prevalence of severe acute rotavirus gastroenteritis and intussusceptions in Ghanaian children under 5 years of age. (22337844)
2012
20
Sonographically guided enema for intussusception reduction: a safer alternative to fluoroscopy. (23011611)
2012
21
The role of plain radiography in assessing intussusception with vascular compromise in children. (22291835)
2011
22
Intussusception: incidence and treatment-insights from the nationwide German surveillance. (21415671)
2011
23
Prolapsed sigmoid intussusception per anus in an elderly man: a case report. (21849068)
2011
24
Small bowel intussusception caused by a jejunal polyp in Peutz-Jeghers syndrome: a case treated with double balloon enteroscopy. (20658191)
2011
25
Laparoscopy-assisted hydrostatic in situ reduction of intussusception: A reasonable alternative? (21430840)
2011
26
Heterotopic gastric mucosa: a rare cause of jejunal intussusception. (21944611)
2011
27
Adenomyoma of the ileum leading to intussusception. (22110422)
2011
28
Intestinal spirochetosis as a causative factor for colocolic intussusception. (21274545)
2011
29
Incidence of intussusception in early infancy: a capture-recapture estimate for Germany. (21698555)
2011
30
Severe type of adult jejunal intussusception caused by long intestinal tube in a patient with intestinal obstruction due to cecal carcinoma. (22688937)
2011
31
Intussusception: an anatomical perspective with review of the literature. (21268121)
2011
32
Voluminous intussusception involving the whole midgut in a teenager: a unique differentiation from abdominal cocoon. (21512845)
2011
33
Multiple Small Bowel Intussusceptions Caused by Kaposi's Sarcoma: The Radiologist's Point of View. (21572620)
2011
34
Paediatric intussusception caused by acquired immunodeficiency syndrome-associated Kaposi sarcoma. (20535484)
2010
35
A ganglioneuroma of the sigmoid colon presenting as leading point of intussusception in a child: a case report. (19159704)
2009
36
Contents of serum albumin after surgical operation in children with acute intussusception]. (19374811)
2009
37
HoxB5 induces endothelial sprouting in vitro and modifies intussusceptive angiogenesis in vivo involving angiopoietin-2. (19403561)
2009
38
Ileo-ileal intussusception due to inverted Meckel's diverticulum. (19803269)
2009
39
Jejunojejunal intussusception by a known jejunal adenocarcinoma. (18815635)
2008
40
Massive mucinous cystadenoma of the appendix with intussusception in an adult: usefulness of reconstructed computed tomography images. (18301985)
2008
41
Intussusception mimicking rectal prolapse. (18327576)
2008
42
Multiple lipomatosis--a rare cause for small bowel intussusception. (18157202)
2007
43
Delta-F508 cystic fibrosis mutation is not linked to intussusception: implications for rotavirus vaccine. (12969205)
2003
44
Laparoscopic reduction of an ileoileal intussusception and resection of an inverted Meckel's diverticulum in an adult. (12728389)
2003
45
Intestinal intussusception and occlusion caused by small bowel polyps in the Peutz-Jeghers syndrome. Management by combined intraoperative enteroscopy and resection through minimal enterostomy: case report. (11313662)
2000
46
Intussusception-type antireflux valve in the Roux-en-Y loop to prevent ascending cholangitis after hepatic portojejunostomy. (2313499)
1990
47
Small bowel obstruction by intussusception in a bladder diverticulum: complication of inguinal hernia repair. (3122870)
1987
48
Recurrent acute pancreatitis and intussusception complicating an intraluminal duodenal diverticulum. (6786954)
1981
49
Extramedullary plasmacytoma of the colon: a rare cause of intussusception. (889191)
1977
50
ACCESSORY PANCREAS WITH INTUSSUSCEPTION. (17863874)
1918

Variations for Intussusception

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Expression for genes affiliated with Intussusception

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Search GEO for disease gene expression data for Intussusception.

Pathways for genes affiliated with Intussusception

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Pathways related to Intussusception according to GeneCards Suite gene sharing:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7CCND1, APC
2
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway58
9.6CRP, CCND1
39.4CRP, IL6
49.4APC, STK11, CCND1
59.4IL6, CCND1
69.4IL6, CCND1
7
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
9.3CD40LG, IL6, WAS
8
Show member pathways
PLK2 and PLK4 events36
Polo-like kinase signaling events in the cell cycle36
9.1STK11, CCND1, IL6
9
Show member pathways
9.1CD40LG, IL6, CCND1
109.1APC, CCND1, IL6
119.1IL6, CCND1, APC
12
Show member pathways
thioredoxin pathway36
8.9CRP, ALB, IL6

Compounds for genes affiliated with Intussusception

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Compounds related to Intussusception according to GeneCards Suite gene sharing:

(show top 50)    (show all 130)
idCompoundScoreTop Affiliating Genes
1refacto4310.0F8, ALB
2kogenate439.9F8, ALB
3sandoglobulin439.8CD40LG, IL6
4gamma globulin439.7ALB, CD40LG, CRP
5tocilizumab43 1210.7IL6, CRP
6p00001439.7CRP, F8, CCND1
7turpentine439.6CRP, IL6
8ivacaftor49 1210.6ALB, CFTR
9pmma439.5CD40LG, CRP, IL6
10iron sucrose439.5IL6, CRP
11okt3439.5IL6, CRP, CD40LG
12sulindac43 1210.5ALB, CCND1, APC
13fenofibrate43 49 1211.4IL6, CRP, CD40LG
14vitamin b12439.4CRP, CD40LG, ALB
15polyethylene glycol439.3ALB, F8, CD40LG, CRP
16dextran sulfate439.3CD40LG, IL6, ALB
17rituximab43 49 1211.3CD40LG, CRP, F8, IL6
18rosuvastatin43 49 28 1212.2CRP, ALB, IL6
19citrate439.2CRP, CFTR, F8, ALB
20endotoxin439.2CD40LG, IL6, CRP, F8
21aspirin43 49 28 2412.2CD40LG, CRP, APC, CFTR, F8
22paraffin439.1CD40LG, APC, CFTR, STK11, CCND1
23ibuprofen43 28 49 24 1213.1CFTR, IL6, ALB
24ascorbic acid43 2410.0ALB, CFTR, CD40LG, CRP
25neopterin439.0CD40LG, CRP, IL6
26adenylate439.0STK11, CCND1, CD40LG, APC, CFTR
27curcumin439.0IL6, APC, CFTR, CCND1
28prednisolone43 28 1211.0F8, ALB, IL6, CRP
29epinephrine43 24 1210.9IL6, CD40LG, CFTR, F8, APC
30aspartate438.9CFTR, F8, ALB, CRP, CD40LG
31folate438.9CRP, APC, CCND1, ALB, CD40LG
32rosiglitazone28 43 49 24 1212.9CRP, ALB, CCND1, IL6
33rapamycin438.9CRP, CD40LG, CCND1, STK11, WAS, APC
34celecoxib43 59 28 49 24 1213.9APC, CCND1, ALB
35methotrexate49 43 1210.8CCND1, CRP, ALB, IL6
36ivig438.8IL6, ALB, CRP, CD40LG, F8
37n acetylcysteine438.7CD40LG, CFTR, CRP, CCND1, IL6
38indomethacin43 28 59 1211.7CD40LG, ALB, IL6, APC, CFTR
39fibrinogen438.7CD40LG, CRP, ALB, IL6, F8
40lactate438.7IL6, F8, ALB, CRP, CD40LG
41creatinine438.7ALB, F8, CRP, IL6, CD40LG
42vitamin d438.6ALB, IL6, CFTR, APC
43norepinephrine43 24 1210.6APC, F8, CD40LG, CFTR, IL6, CRP
44serine438.5F8, WAS, STK11, APC, CFTR, CD40LG
45vegf438.5STK11, CCND1, CRP, IL6, F8, CD40LG
46estrogen438.4CFTR, APC, CCND1, IL6, F8, CD40LG
47glucose438.3CRP, ALB, F8, IL6, STK11, APC
48lipid438.1F8, IL6, WAS, STK11, ALB, CRP
49alanine438.1CRP, CD40LG, ALB, F8, IL6, STK11
50testosterone43 59 24 1210.9CD40LG, ALB, IL6, CCND1, APC, CFTR

GO Terms for genes affiliated with Intussusception

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Cellular components related to Intussusception according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:00310939.6ALB, F8
2extracellular spaceGO:00056158.0CD40LG, CRP, ALB, F8, IL6

Biological processes related to Intussusception according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of epithelial cell proliferation involved in prostate gland developmentGO:006077010.0APC, STK11
2canonical Wnt signaling pathwayGO:00600709.6CCND1, STK11, APC
3muscle cell cellular homeostasisGO:00467169.6IL6, APC
4negative regulation of lipid storageGO:00108889.6IL6, CRP
5cellular response to DNA damage stimulusGO:00069749.4CCND1, STK11, APC
6acute-phase responseGO:00069539.3CRP, F8, IL6
7defense response to Gram-positive bacteriumGO:00508309.3IL6, CRP
8inflammatory responseGO:00069549.1CD40LG, CRP, IL6
9platelet activationGO:00301688.9IL6, F8, ALB, CD40LG
10response to drugGO:00424938.7IL6, CCND1, CFTR

Molecular functions related to Intussusception according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1enzyme bindingGO:00198999.1ALB, CCND1, CFTR
2protein bindingGO:00055156.6CRP, CFTR, APC, WAS, STK11, CCND1

Products for genes affiliated with Intussusception

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Sources for Intussusception

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet