COLON
MCID: INT051
MIFTS: 57

Intussusception (COLON) malady

Gastrointestinal category

Summaries for Intussusception

Sources:
47OMIM, 33MalaCards
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MalaCards: Intussusception, also known as intussusception of intestine, is related to ulcerative colitis and peutz-jeghers syndrome. An important gene associated with Intussusception is STK11 (serine/threonine kinase 11), and among its related pathways are Immune response Oncostatin M signaling via JAK-Stat in human cells and Platelet degranulation . The compounds estrogen and gamma globulin have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and whole blood, and related mouse phenotypes are renal/urinary system and vision/eye.

Description from OMIM:47 147710

Aliases & Classifications for Intussusception

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 47OMIM, 35MeSH, 57SNOMED-CT, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal


Aliases & Descriptions:

intussusception 8 10 45 61
intussusception of intestine 8
invagination of intestine 8
intussusception nos 8
colon 8


External Ids:

Disease Ontology8 DOID:8446
OMIM47 147710
MeSH35 D007443
ICD9CM27 560.0
ICD1025 K56.1

Related Diseases for Intussusception

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Intussusception via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1020)
idRelated DiseaseScoreTop Affiliating Genes
1ulcerative colitis31.1APC, CFTR, CRP, IL6
2peutz-jeghers syndrome30.9APC, STK11
3vascular cancer30.8F8
4adenocarcinoma30.5CYR61, STK11, ANGPT2, CCND1, VEGFA, APC
5adenoma30.5APC, STK11, ANGPT2, CCND1
6aortic aneurysm30.4CRP
7bacteriuria30.4CRP
8amyloidosis30.3CRP, ALB
9atopic dermatitis30.3FLG2
10acromegaly30.2APC
11tuberculosis30.2ALB, CRP
12thyroid cancer30.2ANGPT2, CCND1, APC
13appendicitis30.2CRP
14cystic fibrosis30.1ALB, F8, CFTR
15acute pancreatitis30.1CFTR, IL6, CRP
16hypercalcemia30.1ALB
17insulin resistance30.1F8, CRP, ALB, IL6
18angiosarcoma30.1ANGPT2
19asthma30.1ANGPT2
20bronchiectasis30.1CFTR
21kaposi's sarcoma30.1IL6, F8
22chorioamnionitis30.0CRP, IL6
23arthritis30.0IL6, CRP, ALB
24crohn's disease29.9CRP, ALB
25deficiency anemia29.9EPO, ALB, IL6, CRP
26burkitt's lymphoma29.9WAS, CD40LG, IL6, ALB, CCND1, F8
27portal vein thrombosis29.8F8
28polymyalgia rheumatica29.8CRP
29juvenile polyposis syndrome29.8STK11, APC
30cholera29.8APC, CFTR
31hepatitis c29.8F8, CD40LG, ALB
32vascular disease29.8CYR61, CRP, VEGFA, ANGPT2
33astrocytoma29.8ANGPT2, VEGFA, IL6, STK11
34thrombocytopenia29.8EPO, WAS, CD40LG, ALB, IL6, F8
35leptospirosis29.7CD40LG
36measles29.7CD40LG
37acute leukemia29.7EPO
38kawasaki disease29.7CRP
39cardiac tamponade29.7F8
40sinusitis29.7CFTR
41familial adenomatous polyposis29.7CCND1, APC, STK11
42acute pyelonephritis29.7CRP
43ankylosing spondylitis29.7CRP
44acquired immunodeficiency syndrome29.7IL6, F8, ALB
45stomach cancer29.7CCND1, ANGPT2, VEGFA, APC
46pulmonary disease, chronic obstructive29.7CRP, IL6
47colorectal cancer29.7APC, STK11, VEGFA, CCND1, ANGPT2
48squamous cell carcinoma29.7VEGFA, ANGPT2, APC, CYR61, CCND1, STK11
49sepsis29.7ANGPT2, CRP, IL6, ALB
50systemic lupus erythematosus29.7CRP, CD40LG, F8, IL6

Graphical network of the top 20 diseases related to Intussusception:



Diseases related to intussusception

Clinical Features for Intussusception

Sources:
47OMIM
See all sources

Clinical features from OMIM:

147710

Drugs & Therapeutics for Intussusception

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Intussusception

Drug clinical trials:

Search ClinicalTrials for Intussusception

Search NIH Clinical Center for Intussusception

Search CenterWatch for Intussusception

Genetic Tests for Intussusception

Anatomical Context for Intussusception

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Intussusception:

33
Liver, Lung, Whole blood, Heart, Skeletal muscle, Small intestine, Colon, Pancreas, Breast, Myeloid, B lymphoblasts, B cells, Appendix

Animal Models for Intussusception or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Intussusception

Sources:
51PubMed
See all sources

Articles related to Intussusception:

(show top 50)    (show all 703)
idTitleAuthorsYear
1
Colo-colic intussusception secondary to lipomatous polyp in an adult. (23462651)
2013
2
Anal protrusion of an ileo-colic intussusception in an adult with persistent ascending and descending mesocolons: a case report. (23375100)
2013
3
A High Incidence of Intussusception Revealed by a Retrospective Hospital-Based Study in Nha Trang, Vietnam between 2009 and 2011. (24155653)
2013
4
Comparison of 2-view abdominal radiographs with ultrasound in children with suspected intussusception. (23364378)
2013
5
Recurrent retrograde intussusception after roux-en-Y gastric bypass: intussusception reduction by the transhepatic approach. (23973034)
2013
6
Pediatric postoperative intussusception in the minimally invasive surgery era: a 13-year, single center experience. (23571141)
2013
7
Total ileocolic intussusception with rectal prolapse presenting in an adult: a case report and review of the literature. (24059349)
2013
8
Transient intussusception: rare cause of abdominal pain in cystic fibrosis. (24225734)
2013
9
Jejunal intussusception associated with lymphoma in a horse. (23629018)
2013
10
Invaginated Meckel's diverticulum: a rare cause of small intestine intussusception in adults. (23552542)
2013
11
Needle decompression to avoid tension pneumoperitoneum and hemodynamic compromise after pneumatic reduction of pediatric intussusception. (23283408)
2013
12
Intussusception secondary to anaphylactic reaction to salmon roe (ikura). (24134755)
2013
13
Reduction of intussusception: defining a better index of successful non-operative treatment. (23254683)
2013
14
Laparoscopic surgery for an intussusception caused by a lipoma in the ascending colon. (23700576)
2013
15
Intussusception secondary to a meckel diverticulum in an adolescent. (23547727)
2013
16
The intussusception in patients with Crohn's disease: the role of the surgeon. (21971920)
2013
17
Sonographically guided enema for intussusception reduction: a safer alternative to fluoroscopy. (23011611)
2012
18
JAMA patient page. Intussusception. (22318285)
2012
19
Predictors of failed enema reduction in childhood intussusception. (22595574)
2012
20
Delayed repeated enema and operative findings after unsuccessful primary enema for intussusception. (22773354)
2012
21
External manual reduction of paediatric idiopathic ileocolic intussusception with ultrasound assistance. (22875207)
2012
22
Unusual cause of adult intussusception: diffuse large B-cell non-Hodgkin's lymphoma: a case report and review. (23242720)
2012
23
Hepatic portal venous gas and "the aquarium sign" due to intussusception in kawasaki disease. (22640014)
2012
24
Heterotopic pancreas leading to ileo-ileal intussusception. (22953306)
2012
25
Colocolic intussusception with rectal prolapse reduced laparoscopically. (23265112)
2012
26
Ileocecal-colonic intussusception caused by cecal adenocarcinoma A case report. (23070265)
2012
27
Case of the month. Intussusception. (22928285)
2012
28
Association of viral isolates from stool samples with intussusception in children. (21757385)
2011
29
Pediatric radiology fellows' experience with intussusception reduction. (21567142)
2011
30
Re: small bowel intussusception in celiac disease: revisiting a classic association. (21164306)
2011
31
Adult intussusception: 5-year experience in Sarawak. (22111440)
2011
32
Small bowel intussusception due to metastatic intestinal carcinosarcoma from a pulmonary primary. (23754896)
2011
33
Complicated Rapunzel syndrome mimicking intussusception. (22696764)
2011
34
Rotavirus vaccine and intussusception:report from an expert consultation. (21800466)
2011
35
Multiple intestinal intussusceptions in Peutz-Jeghers' syndrome: a case report. (20306920)
2010
36
Intussusception of small intestine due to metastasis of large cell carcinoma of the lung with a rhabdoid phenotype. (20956201)
2010
37
Intussusception Caused by Yersinia enterocolitica Enterocolitis in a Patient with Sickle Cell Anemia. (21151549)
2010
38
Non-Hodgkin's lymphoma revealed by an ilio-colic intussusception in a Moroccan patient: a case report. (21119996)
2010
39
Ileo-ileal intussusception due to inverted Meckel's diverticulum. (19803269)
2009
40
Intussusception mimicking rectal prolapse. (18327576)
2008
41
Rectal prolapse, rectal intussusception, rectocele, solitary rectal ulcer syndrome, and enterocele. (18794001)
2008
42
Intestinal schistosomiasis manifesting as colonic intussusception arising from a mucocele of the appendix: report of a case. (18612796)
2008
43
Multiple lipomatosis--a rare cause for small bowel intussusception. (18157202)
2007
44
Meckel's diverticulum induced intrauterine intussusception associated with ileal atresia complicated by meconium peritonitis. (17588844)
2007
45
Intussusception complicating typhoid fever. (16055906)
2005
46
Adult intussusception due to inverted Meckel's diverticulum: laparoscopic approach. (12598757)
2003
47
Intestinal intussusception and occlusion caused by small bowel polyps in the Peutz-Jeghers syndrome. Management by combined intraoperative enteroscopy and resection through minimal enterostomy: case report. (11313662)
2000
48
Intestinal intussusception caused by a jejunal Dieulafoy lesion. (10882976)
2000
49
Sigmoido-anal intussusception presenting as rectal prolapse: role of endoscopic diagnosis. (9647396)
1998
50
Intestinal tuberculosis as an etiological factor in intussusception. (13542195)
1958

Genetic Variations for Intussusception

Expression for genes affiliated with Intussusception

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Intussusception

Search GEO for disease gene expression data for Intussusception.

Pathways for genes affiliated with Intussusception

Sources:
54Reactome, 12EMD Millipore, 38NCBI BioSystems Database, 30KEGG
See all sources

Pathways related to Intussusception according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Immune response Oncostatin M signaling via JAK-Stat in human cells
Hide members
9.5IL6, VEGFA, CCND1
2
Hide members
9.5ALB, VEGFA, F8
39.4VEGFA, STK11, APC, CCND1
49.4ALB, IL6, CRP
59.2VEGFA, ANGPT2, EPO, IL6
69.2ALB, CFTR, CRP, F8
79.1CCND1, APC, CYR61
88.8CCND1, STK11, VEGFA, ANGPT2, EPO, IL6

Compounds for genes affiliated with Intussusception

Sources:
45Novoseek, 29IUPHAR, 60Tocris Bioscience, 11DrugBank, 24HMDB, 50PharmGKB
See all sources

Compounds related to Intussusception according to GeneCards/GeneDecks:

(show top 50)    (show all 106)
idCompoundScoreTop Affiliating Genes
1estrogen4510.7F8
2gamma globulin4510.6CRP
3pge24510.5VEGFA
4triamcinolone acetonide45 2911.2CFTR, EPO
5indomethacin45 60 29 1113.1APC, CFTR
6ivig4510.1CRP, CD40LG, F8
7norepinephrine45 11 2412.1APC, F8, CFTR
8citrate phosphate dextrose4510.1F8, EPO
9epinephrine45 11 2412.0CD40LG, CFTR, F8
10tween 80459.9ALB, EPO, F8
11refacto459.9F8, ALB
12iron sucrose459.9IL6, EPO, CRP
13cyclosporin a45 29 6011.9F8, CD40LG, CFTR, ANGPT2
14phenylbutyrate459.9CFTR, EPO, CCND1
15bucillamine459.9IL6, CRP, VEGFA
16rosiglitazone45 50 29 11 2413.8CCND1, IL6
17progestin459.7F8, CCND1, VEGFA, ANGPT2
18pmma459.7CRP, IL6, CD40LG
19heparin45 29 11 2412.7CD40LG, APC, F8, VEGFA
20rituximab45 50 1111.7CD40LG, IL6, CRP, F8
21polysulfone459.7ALB, EPO
22perindopril45 50 1111.7ALB, VEGFA, CRP
23aspartate459.6F8, CD40LG, CFTR, ALB
24infliximab45 50 1111.6CRP, VEGFA, ANGPT2, IL6
25bortezomib45 1110.6VEGFA, CCND1, CD40LG, IL6
26polyethylene glycol459.6CRP, CD40LG, ALB, F8
27vitamin b12459.6EPO, CRP, ALB, CD40LG
28aspirin45 50 29 2412.5CD40LG, F8, CRP, CFTR, APC
29creatinine459.4F8, CRP, ANGPT2, EPO, ALB
30thalidomide45 50 60 1112.4CCND1, CD40LG, EPO, IL6, VEGFA
31ascorbic acid45 2410.4CRP, ALB, CFTR, EPO
32curcumin459.3CFTR, CCND1, APC, VEGFA, IL6
33atorvastatin45 50 29 11 2413.2CD40LG, CRP, IL6, VEGFA
34methotrexate45 50 1111.2IL6, ALB, CCND1, EPO, CRP
35celecoxib45 60 29 50 11 2414.1EPO, ALB, ANGPT2, VEGFA, CCND1, APC
36paraffin459.1CD40LG, CFTR, VEGFA, STK11, APC, CCND1
37fibrinogen459.1CRP, CD40LG, ANGPT2, F8, IL6, ALB
38n acetylcysteine459.1CRP, CCND1, CD40LG, IL6, VEGFA, CFTR
39ly294002459.1IL6, CRP, EPO, ANGPT2, CCND1, VEGFA
40lactate458.9EPO, CRP, ALB, F8, IL6, CD40LG
41vitamin d458.9APC, EPO, IL6, CFTR, ALB
42prostacyclin458.9CRP, F8, APC, VEGFA, CYR61
43prednisolone45 29 1110.8F8, ALB, IL6, CRP
44rapamycin458.8CD40LG, WAS, EPO, CCND1, APC, CRP
45alanine458.7CFTR, ALB, IL6, CD40LG, STK11, F8
46testosterone45 60 11 2411.5CCND1, APC, CRP, CD40LG, EPO, IL6
47folate458.3EPO, CYR61, ALB, APC, CCND1, CRP
48lipid457.9APC, STK11, WAS, CRP, ALB, IL6
49tyrosine457.7APC, WAS, F8, VEGFA, ANGPT2, EPO
50vegf457.6EPO, STK11, VEGFA, ANGPT2, F8, CCND1

GO Terms for genes affiliated with Intussusception

Sources:
16Gene Ontology
See all sources

Cellular components related to Intussusception according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.5ALB, VEGFA, F8
2extracellular spaceGO:0056157.9ALB, F8, CRP, VEGFA, ANGPT2, CD40LG
3extracellular regionGO:0055766.9F8, CRP, PRB3, VEGFA, ANGPT2, EPO

Biological processes related to Intussusception according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of epithelial cell proliferation involved in prostate gland developmentGO:06077010.2APC, STK11
2negative regulation of lipid storageGO:0108889.9CRP, IL6
3canonical Wnt receptor signaling pathwayGO:0600709.8STK11, APC, CCND1
4response to estrogen stimulusGO:0436279.8CFTR, EPO, CCND1
5acute-phase responseGO:0069539.8F8, CRP, IL6
6positive regulation of focal adhesion assemblyGO:0518949.6EPB41L5, VEGFA
7platelet degranulationGO:0025769.5F8, VEGFA, ALB
8blood coagulationGO:0075969.2WAS, F8, VEGFA, ANGPT2, ALB
9agingGO:0075689.2IL6, EPO, CRP
10platelet activationGO:0301689.1ALB, IL6, CD40LG, VEGFA, F8
11positive regulation of protein phosphorylationGO:0019348.9CYR61, VEGFA, CCND1
12negative regulation of apoptotic processGO:0430668.3APC, VEGFA, CD40LG, CYR61, IL6, ALB

Products for genes affiliated with Intussusception

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Intussusception

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet