COLON
MCID: INT051
MIFTS: 60

Intussusception (COLON) malady

Gastrointestinal diseases category

Summaries for Intussusception

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MalaCards based summary: Intussusception, also known as intussusception of intestine, is related to peutz-jeghers syndrome and gastroenteritis, and has symptoms including autosomal dominant inheritanceand intussusception. An important gene associated with Intussusception is STK11 (serine/threonine kinase 11), and among its related pathways are Presenilin action in Notch and Wnt signaling and Jak/Stat Pathway. The compounds refacto and kogenate have been mentioned in the context of this disorder. Affiliated tissues include colon, appendix and small intestine, and related mouse phenotypes are reproductive system and liver/biliary system.

Description from OMIM:46 147710

Aliases & Classifications for Intussusception

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Sources:
9Disease Ontology, 11DISEASES, 44Novoseek, 61UMLS, 46OMIM, 56SNOMED-CT, 34MeSH, 28ICD9CM, 26ICD10
See all sources

Intussusception, Aliases & Descriptions:

Name: Intussusception 9 11 44 61
Intussusception of Intestine 9 61
Invagination of Intestine 9 61
 
Intussusception Nos 9
Colon 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


External Ids:

Disease Ontology9 DOID:8446
OMIM46 147710
MeSH34 D007443
ICD9CM28 560.0
ICD1026 K56.1

Related Diseases for Intussusception

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Diseases related to Intussusception via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 252)
idRelated DiseaseScoreTop Affiliating Genes
1peutz-jeghers syndrome31.5STK11, APC
2gastroenteritis30.9ZNF185
3intestinal obstruction30.6CFTR, ALB
4cholangitis30.3CFTR, ALB
5acute pancreatitis30.2CRP, IL6, CFTR
6crohn's disease30.1ALB, CRP
7kaposi's sarcoma30.1IL6, F8
8cystic fibrosis30.0CFTR, F8, ALB
9multiple myeloma30.0CCND1, IL6
10peritonitis29.9IL6, ALB, CRP
11pancreatitis29.9CFTR, IL6, ALB, CRP
12familial adenomatous polyposis29.9APC, STK11, CCND1
13deficiency anemia29.7IL6, ALB, CRP
14acquired immunodeficiency syndrome29.7IL6, F8, ALB
15systemic lupus erythematosus29.7IL6, F8, CRP, CD40LG
16colorectal cancer29.6APC, STK11, CCND1
17lung cancer29.5STK11, CCND1, ALB
18sepsis29.5IL6, ALB, CRP
19diarrhea29.4CRP, ALB, ZNF185, CFTR
20burkitt's lymphoma29.3WAS, CCND1, IL6, F8, ALB, CD40LG
21myeloma29.3CCND1, IL6, ALB, CD40LG
22leukemia29.3CD40LG, F8, IL6, CCND1, CFTR
23ileocolitis10.7
24meckel's diverticulum10.6
25lipoma10.6
26cardiac tamponade10.5F8
27schnitzler syndrome10.5CD40LG
28rectal prolapse10.5
29hemorrhagic fever10.5CD40LG
30scrub typhus10.5CD40LG
31hepatitis a10.5F8
32thrombophlebitis10.5F8
33bacteriuria10.5CRP
34adenocarcinoma10.4
35pyelonephritis10.4CRP
36aortic aneurysm10.4CRP
37primary immunodeficiency disease10.4WAS, CD40LG
38duodenitis10.4
39gastroduodenitis10.4
40adenoma10.4
41juvenile polyposis syndrome10.4STK11, APC
42pregnancy loss10.3CD40LG, F8
43viral hepatitis10.3F8
44vascular disease10.3F8, IL6
45gastrointestinal stromal tumor10.3
46intestinal atresia10.3
47melanoma10.3
48antiphospholipid syndrome10.3F8, CD40LG
49malaria10.2ALB
50macroglobulinemia, waldenstrom, somatic10.2CCND1, CD40LG

Graphical network of the top 20 diseases related to Intussusception:



Diseases related to intussusception

Symptoms for Intussusception

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Clinical features from OMIM:

147710

HPO human phenotypes related to Intussusception:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 intussusception HP:0002576

Drugs & Therapeutics for Intussusception

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Drug clinical trials:

Search ClinicalTrials for Intussusception

Search NIH Clinical Center for Intussusception

Genetic Tests for Intussusception

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Anatomical Context for Intussusception

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MalaCards organs/tissues related to Intussusception:

32
Colon, Appendix, Small intestine, Pancreas, Lung, B cells, Breast, Liver, Endothelial, Heart, Skeletal muscle, Myeloid

Animal Models for Intussusception or affiliated genes

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Publications for Intussusception

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Articles related to Intussusception:

(show top 50)    (show all 739)
idTitleAuthorsYear
1
Adenomyoma of the small intestine a rare pathological lead point for intussusception in an infant. (25392787)
2014
2
Jejunojejunal intussusception secondary to submucosal lipoma resulting in a 5-year history of intermittent abdominal pain. (25355752)
2014
3
Postoperative intussusception in a neonate with congenital cutis laxa and huge hiatal hernia. (24834384)
2014
4
Colo-colic intussusception secondary to lipomatous polyp in an adult. (23462651)
2013
5
Intussusception with complete twisting of mesenteric root after Roux-en-Y gastric bypass. (23522620)
2013
6
Perspectives on intussusception. (23597529)
2013
7
Colonic intussusception caused by anisakiasis: a case report and review of the literature. (23318852)
2013
8
Jejunal intussusception and polyps with different types of malignant transformation in Peutz-Jeghers syndrome: Report of a case. (23255928)
2013
9
Appendicular intussusception with lymphoid hyperplasia. (23847834)
2013
10
Intussusception risk and disease prevention associated with rotavirus vaccines in Australia's National Immunization Program. (23964090)
2013
11
Management of intussusception in resource-limited settings. (23994003)
2013
12
Intussusception as a presenting feature of Burkitt lymphoma: implications for management and outcome. (21969235)
2012
13
Ileocolic intussusception due to a cecal endometriosis: case report and review of literature. (22676322)
2012
14
Antibiotics administration before enema reduction of intussusception: is it necessary? (22595575)
2012
15
Appendiceal intussusception to the cecum caused by mucocele of the appendix: Laparoscopic approach. (22706297)
2012
16
Japanese guidelines for the management of intussusception in children, 2011. (22748165)
2012
17
Prevalence of severe acute rotavirus gastroenteritis and intussusceptions in Ghanaian children under 5 years of age. (22337844)
2012
18
Sonographically guided enema for intussusception reduction: a safer alternative to fluoroscopy. (23011611)
2012
19
The role of plain radiography in assessing intussusception with vascular compromise in children. (22291835)
2011
20
Intussusception: incidence and treatment-insights from the nationwide German surveillance. (21415671)
2011
21
Prolapsed sigmoid intussusception per anus in an elderly man: a case report. (21849068)
2011
22
Small bowel intussusception caused by a jejunal polyp in Peutz-Jeghers syndrome: a case treated with double balloon enteroscopy. (20658191)
2011
23
Laparoscopy-assisted hydrostatic in situ reduction of intussusception: A reasonable alternative? (21430840)
2011
24
Heterotopic gastric mucosa: a rare cause of jejunal intussusception. (21944611)
2011
25
Adenomyoma of the ileum leading to intussusception. (22110422)
2011
26
Intestinal spirochetosis as a causative factor for colocolic intussusception. (21274545)
2011
27
Incidence of intussusception in early infancy: a capture-recapture estimate for Germany. (21698555)
2011
28
Severe type of adult jejunal intussusception caused by long intestinal tube in a patient with intestinal obstruction due to cecal carcinoma. (22688937)
2011
29
Intussusception: an anatomical perspective with review of the literature. (21268121)
2011
30
Voluminous intussusception involving the whole midgut in a teenager: a unique differentiation from abdominal cocoon. (21512845)
2011
31
Multiple Small Bowel Intussusceptions Caused by Kaposi's Sarcoma: The Radiologist's Point of View. (21572620)
2011
32
Paediatric intussusception caused by acquired immunodeficiency syndrome-associated Kaposi sarcoma. (20535484)
2010
33
A ganglioneuroma of the sigmoid colon presenting as leading point of intussusception in a child: a case report. (19159704)
2009
34
Contents of serum albumin after surgical operation in children with acute intussusception]. (19374811)
2009
35
HoxB5 induces endothelial sprouting in vitro and modifies intussusceptive angiogenesis in vivo involving angiopoietin-2. (19403561)
2009
36
Ileo-ileal intussusception due to inverted Meckel's diverticulum. (19803269)
2009
37
Massive mucinous cystadenoma of the appendix with intussusception in an adult: usefulness of reconstructed computed tomography images. (18301985)
2008
38
Intussusception mimicking rectal prolapse. (18327576)
2008
39
Multiple lipomatosis--a rare cause for small bowel intussusception. (18157202)
2007
40
Intussusception due to intestinal anisakiasis: a case report. (15160751)
2004
41
Delta-F508 cystic fibrosis mutation is not linked to intussusception: implications for rotavirus vaccine. (12969205)
2003
42
Laparoscopic reduction of an ileoileal intussusception and resection of an inverted Meckel's diverticulum in an adult. (12728389)
2003
43
Intestinal intussusception and occlusion caused by small bowel polyps in the Peutz-Jeghers syndrome. Management by combined intraoperative enteroscopy and resection through minimal enterostomy: case report. (11313662)
2000
44
Intussusception secondary to Meckel's diverticulum detection with Tc-99m monoclonal antibodies to granulocytes (Leukoscan). (8922842)
1996
45
Large-cell carcinoma of the lung. With major bleeding and intussusception. (1328355)
1992
46
Intussusception-type antireflux valve in the Roux-en-Y loop to prevent ascending cholangitis after hepatic portojejunostomy. (2313499)
1990
47
Small bowel obstruction by intussusception in a bladder diverticulum: complication of inguinal hernia repair. (3122870)
1987
48
Recurrent acute pancreatitis and intussusception complicating an intraluminal duodenal diverticulum. (6786954)
1981
49
Extramedullary plasmacytoma of the colon: a rare cause of intussusception. (889191)
1977
50
ACCESSORY PANCREAS WITH INTUSSUSCEPTION. (17863874)
1918

Variations for Intussusception

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Expression for genes affiliated with Intussusception

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Expression patterns in normal tissues for genes affiliated with Intussusception

Search GEO for disease gene expression data for Intussusception.

Pathways for genes affiliated with Intussusception

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Pathways related to Intussusception according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7CCND1, APC
2
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway59
9.6CRP, CCND1
39.4CRP, IL6
49.4APC, STK11, CCND1
59.4IL6, CCND1
69.4IL6, CCND1
7
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
9.3CD40LG, IL6, WAS
8
Show member pathways
PLK2 and PLK4 events37
Polo-like kinase signaling events in the cell cycle37
9.1STK11, CCND1, IL6
9
Show member pathways
9.1CD40LG, IL6, CCND1
109.1APC, CCND1, IL6
119.1IL6, CCND1, APC
12
Show member pathways
thioredoxin pathway37
8.9CRP, ALB, IL6
138.9CRP, ALB, F8, CFTR

Compounds for genes affiliated with Intussusception

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Compounds related to Intussusception according to GeneCards/GeneDecks:

(show top 50)    (show all 130)
idCompoundScoreTop Affiliating Genes
1refacto4410.0ALB, F8
2kogenate449.9ALB, F8
3sandoglobulin449.8CD40LG, IL6
4gamma globulin449.7ALB, CD40LG, CRP
5tocilizumab44 1210.7CRP, IL6
6p00001449.7CRP, F8, CCND1
7turpentine449.6IL6, CRP
8pmma449.5CD40LG, CRP, IL6
9iron sucrose449.5IL6, CRP
10okt3449.5IL6, CRP, CD40LG
11sulindac44 1210.5CCND1, APC, ALB
12vitamin b12449.4ALB, CD40LG, CRP
13fenofibrate44 50 1211.4IL6, CRP, CD40LG
14polyethylene glycol449.3ALB, F8, CD40LG, CRP
15dextran sulfate449.3IL6, ALB, CD40LG
16rituximab44 50 1211.3CD40LG, CRP, F8, IL6
17rosuvastatin44 50 29 1212.2ALB, CRP, IL6
18citrate449.2CRP, CFTR, F8, ALB
19endotoxin449.2CD40LG, IL6, CRP, F8
20aspirin44 50 29 2512.2CD40LG, CRP, APC, CFTR, F8
21celecoxib44 60 29 50 25 1214.2CCND1, APC, ALB
22cdp571449.1CRP, IL6
23paraffin449.1CD40LG, APC, CFTR, STK11, CCND1
24ibuprofen44 29 50 25 1213.1ALB, IL6, CFTR
25ascorbic acid44 2510.0ALB, CFTR, CD40LG, CRP
26neopterin449.0IL6, CRP, CD40LG
27adenylate449.0CCND1, CD40LG, CFTR, APC, STK11
28curcumin449.0IL6, APC, CFTR, CCND1
29prednisolone44 29 1211.0F8, ALB, IL6, CRP
30epinephrine44 25 1210.9IL6, CD40LG, CFTR, F8, APC
31aspartate448.9CFTR, F8, ALB, CRP, CD40LG
32folate448.9CRP, APC, CCND1, ALB, CD40LG
33rosiglitazone29 44 50 25 1212.9CRP, ALB, CCND1, IL6
34rapamycin448.9CRP, CD40LG, CCND1, STK11, WAS, APC
35methotrexate50 44 1210.8CRP, IL6, ALB, CCND1
36ivig448.8IL6, ALB, CRP, CD40LG, F8
37n acetylcysteine448.7CD40LG, CFTR, CRP, CCND1, IL6
38indomethacin44 29 60 1211.7CD40LG, ALB, IL6, APC, CFTR
39fibrinogen448.7CD40LG, CRP, ALB, IL6, F8
40lactate448.7IL6, F8, ALB, CRP, CD40LG
41creatinine448.7ALB, F8, CRP, IL6, CD40LG
42vitamin d448.6APC, IL6, ALB, CFTR
43norepinephrine44 25 1210.6APC, F8, CD40LG, CFTR, IL6, CRP
44serine448.5F8, WAS, STK11, APC, CFTR, CD40LG
45vegf448.5STK11, CCND1, CRP, IL6, F8, CD40LG
46estrogen448.4CFTR, APC, CCND1, IL6, F8, CD40LG
47glucose448.3CRP, ALB, F8, IL6, STK11, APC
48lipid448.1F8, IL6, WAS, STK11, ALB, CRP
49alanine448.1CRP, CD40LG, ALB, F8, IL6, STK11
50testosterone44 60 25 1210.9CD40LG, ALB, IL6, CCND1, APC, CFTR

GO Terms for genes affiliated with Intussusception

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Cellular components related to Intussusception according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.6ALB, F8
2extracellular spaceGO:0056158.0CD40LG, CRP, ALB, F8, IL6

Biological processes related to Intussusception according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of epithelial cell proliferation involved in prostate gland developmentGO:06077010.0APC, STK11
2canonical Wnt signaling pathwayGO:0600709.6CCND1, STK11, APC
3muscle cell cellular homeostasisGO:0467169.6IL6, APC
4negative regulation of lipid storageGO:0108889.6IL6, CRP
5cellular response to DNA damage stimulusGO:0069749.4CCND1, STK11, APC
6acute-phase responseGO:0069539.3CRP, F8, IL6
7defense response to Gram-positive bacteriumGO:0508309.3IL6, CRP
8inflammatory responseGO:0069549.1CD40LG, CRP, IL6
9platelet activationGO:0301688.9IL6, F8, ALB, CD40LG
10response to drugGO:0424938.7IL6, CCND1, CFTR

Molecular functions related to Intussusception according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1enzyme bindingGO:0198999.1ALB, CCND1, CFTR
2protein bindingGO:0055156.6CRP, CFTR, APC, WAS, STK11, CCND1

Products for genes affiliated with Intussusception

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Sources for Intussusception

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet