COLON
MCID: INT051
MIFTS: 59

Intussusception (COLON) malady

Gastrointestinal diseases category

Summaries for Intussusception

About this section
Sources:
46OMIM, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Intussusception, also known as intussusception of intestine, is related to ulcerative colitis and inflammatory bowel disease. An important gene associated with Intussusception is STK11 (serine/threonine kinase 11), and among its related pathways are Immune response Oncostatin M signaling via JAK-Stat in human cells and Platelet degranulation . The compounds estrogen and gamma globulin have been mentioned in the context of this disorder. Affiliated tissues include colon, appendix and small intestine, and related mouse phenotypes are renal/urinary system and vision/eye.

Description from OMIM:46 147710

Aliases & Classifications for Intussusception

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 46OMIM, 34MeSH, 56SNOMED-CT, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

intussusception 8 10 44 60
intussusception of intestine 8
invagination of intestine 8
intussusception nos 8
colon 8


External Ids:

Disease Ontology8 DOID:8446
OMIM46 147710
MeSH34 D007443
ICD9CM27 560.0
ICD1025 K56.1

Related Diseases for Intussusception

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Intussusception via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1043)
idRelated DiseaseScoreTop Affiliating Genes
1ulcerative colitis31.1CFTR, IL6, CRP, APC
2inflammatory bowel disease30.9IL6
3peutz-jeghers syndrome30.9APC, STK11
4breast cancer30.9CCND1, STK11, VEGFA, ANGPT2, CYR61
5vascular cancer30.8F8
6adenocarcinoma30.5CCND1, APC, STK11, VEGFA, ANGPT2, CYR61
7pneumonia30.4CRP, IL6, CFTR
8adenoma30.4ANGPT2, STK11, APC, CCND1
9prostate cancer30.4CCND1, APC, VEGFA, ANGPT2, CYR61, IL6
10pancreatic cancer30.4CCND1, STK11, VEGFA, CFTR
11aortic aneurysm30.4CRP
12hepatocellular carcinoma30.4CCND1, APC, F8, STK11, VEGFA, ANGPT2
13ovarian cancer30.4ANGPT2, VEGFA, CCND1
14bacteriuria30.3CRP
15melanoma30.3CCND1, STK11, VEGFA, ANGPT2, CYR61, CFTR
16amyloidosis30.3ALB, CRP
17pancreatitis30.3ALB, CFTR, IL6, CRP
18atopic dermatitis30.2FLG2
19hepatitis a30.2F8
20acromegaly30.2APC
21esophageal cancer30.2CCND1
22neuropathy30.2ALB
23sarcoma30.2F8, ANGPT2
24tuberculosis30.2CRP, ALB
25thyroid cancer30.1ANGPT2, APC, CCND1
26appendicitis30.1CRP
27cholangitis30.1ALB, CFTR
28cystic fibrosis30.1ALB, CFTR, F8
29acute pancreatitis30.1CRP, IL6, CFTR
30colon cancer30.1CCND1, APC, STK11, VEGFA, CFTR
31endometriosis30.1IL6, CYR61, ANGPT2, VEGFA
32burkitt's lymphoma30.1ALB, IL6, CD40LG, F8, WAS, CCND1
33hypercalcemia30.1ALB
34juvenile polyposis syndrome30.1STK11, APC
35angiosarcoma30.0ANGPT2
36bronchiectasis30.0CFTR
37gastroenteritis30.0ZNF185, PPT2
38hepatitis30.0CD40LG, F8
39plasmacytoma30.0IL6
40chorioamnionitis30.0IL6, CRP
41endometrial carcinoma30.0CCND1, VEGFA, ANGPT2, CYR61
42obesity30.0CRP, IL6
43peritonitis30.0CRP, IL6, ALB
44diabetes mellitus30.0F8, CRP, VEGFA, ANGPT2, CD40LG, IL6
45asthma30.0ANGPT2
46pyelonephritis30.0CRP
47arthritis29.9ALB, IL6, CRP
48kidney cancer29.9VEGFA
49papillary thyroid carcinoma29.9CCND1, APC, ANGPT2
50hypertension29.9CRP, ALB

Graphical network of the top 20 diseases related to Intussusception:



Diseases related to intussusception

Clinical Features for Intussusception

About this section
Sources:
46OMIM
See all sources

Clinical features from OMIM:

147710

Drugs & Therapeutics for Intussusception

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Intussusception

Drug clinical trials:

Search ClinicalTrials for Intussusception

Search NIH Clinical Center for Intussusception

Search CenterWatch for Intussusception

Genetic Tests for Intussusception

About this section

Anatomical Context for Intussusception

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Intussusception:

32
Colon, Appendix, Small intestine, Pancreas, Lung, B cells, Breast, Liver, Endothelial, Skeletal muscle, Myeloid, Heart

Animal Models for Intussusception or affiliated genes

About this section
Sources:
36MGI
See all sources

Publications for Intussusception

About this section
Sources:
50PubMed
See all sources

Articles related to Intussusception:

(show top 50)    (show all 715)
idTitleAuthorsYear
1
Small bowel intussusception in adults. (24417823)
2014
2
Perspectives on intussusception. (23597529)
2013
3
Ileal duplication mimicking intestinal intussusception: a congenital condition rarely reported in adult. (24151372)
2013
4
Colocolic intussusception in an older child: a rare case report and a literature review. (23533908)
2013
5
Laparoscopic reduction of ileoileal intussusception in Henoch-Schonlein purpura. (23904434)
2013
6
Osteosarcoma metastasis causing ileo-ileal intussusception. (23938137)
2013
7
What is your diagnosis? Gastroesophageal intussusception. (23363277)
2013
8
Ileocolic intussusception secondary to a type II low-grade appendiceal mucinous neoplasm. (23351140)
2013
9
Colon angiolipoma with intussusception: a case report and literature review. (23497239)
2013
10
Double intussusceptions with small intestinal adenoma in pregnancy. (24021318)
2013
11
Intussusception: as the cause of mechanical bowel obstruction in adults. (23354345)
2013
12
Strangulating ileocolic intussusception in pregnancy. (24293856)
2012
13
Jejunal intussusception: a cause of upper gastrointestinal bleeding? (23175009)
2012
14
Accuracy of plain radiographs to exclude the diagnosis of intussusception. (22929143)
2012
15
Ileocolic intussusception due to an inverted Meckel's diverticulum. (21752739)
2012
16
Adult intussusception with cecal adenocarcinoma: Successful treatment by laparoscopy-assisted surgery following preoperative reduction. (22655128)
2012
17
Heterotopic pancreas as a lead point for ileoileal intussusception. (22524758)
2012
18
Tuberculosis in a renal allograft recipient presenting with intussusception. (22279345)
2012
19
Circumferential intimal tear in type A aortic dissection with intimo-intimal intussusception into left ventricle and left main coronary artery occlusion. (22676981)
2012
20
Intussusception and metastatic colon cancer in an adult with cystic fibrosis. (22688367)
2012
21
Postoperative intussusception in infants and children: a report of seven cases. (23554732)
2012
22
Post-transplant lymphoproliferative disorder presented as small bowel intussusception in adult liver transplant patient. (22324047)
2012
23
Gastroduodenal intussusception resulting from large hyperplastic polyp. (23094233)
2012
24
Intussusception of the small intestine caused by a primary melanoma? (22379466)
2012
25
Ultrasonographic diagnosis and surgical management of double intestinal intussusception in 3 dogs. (23372193)
2012
26
Incidence of intussusception in early infancy: a capture-recapture estimate for Germany. (21698555)
2011
27
Intussusception in children: cost-effectiveness of ultrasound vs diagnostic contrast enema. (21683206)
2011
28
Air encircling the intussusceptum on air enema for intussusception reduction: an indication for surgery? (21081577)
2011
29
Intussusception: a disease with usually delayed presentation. (22248906)
2011
30
Pneumatic reduction of intussusception in children at Korle Bu Teaching Hospital: an initial experience. (22005360)
2011
31
A case of hemolytic uremic syndrome preceded by intussusception. (21738552)
2011
32
Ileal perineurioma as a cause of intussusception. (21437510)
2011
33
Adult intussusception caused by an appendiceal mucocele and reduced by colonoscopy. (22741125)
2011
34
Interloop fluid in intussusception. (21928048)
2011
35
Endoscopic image of an ileo-colonic intussusception. (21736399)
2011
36
Recurrent endometrial stromal sarcoma in the cecum causing intussusception. (20464405)
2011
37
Appendicular mucocele as cause of intestinal intussusception: diagnostic by computer tomography. (21039071)
2010
38
Systematic review on ventral rectopexy for rectal prolapse and intussusception. (19438880)
2010
39
A ganglioneuroma of the sigmoid colon presenting as leading point of intussusception in a child: a case report. (19159704)
2009
40
Jejunal small ectopic pancreas developing into jejunojejunal intussusception: a rare cause of ileus. (19701981)
2009
41
Severe pulmonary tuberculosis complicating Ileocecal intussusception due to intestinal tuberculosis: a case report. (18620597)
2008
42
Asymptomatic small bowel intussusception associated with post-transplant lymphoproliferative disease. (15049803)
2004
43
Delta-F508 cystic fibrosis mutation is not linked to intussusception: implications for rotavirus vaccine. (12969205)
2003
44
Peutz-Jeghers syndrome associated with intestinal intussusception: a case report. (12575811)
2002
45
Lipomatosis of the small intestine and colon associated with intussusception in the ileocecal region. (9869738)
1999
46
Postnatal intussusception in a premature infant, causing jejunal atresia. (8861489)
1996
47
Large-cell carcinoma of the lung. With major bleeding and intussusception. (1328355)
1992
48
Small bowel obstruction by intussusception in a bladder diverticulum: complication of inguinal hernia repair. (3122870)
1987
49
Jejunal atresia secondary to intrauterine intussusception, presenting as acute perforation. (3580981)
1987
50
Prevention of intussusception in Peutz-Jeghers syndrome. (467186)
1979

Genetic Variations for Intussusception

About this section

Expression for genes affiliated with Intussusception

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Intussusception

Search GEO for disease gene expression data for Intussusception.

Pathways for genes affiliated with Intussusception

About this section
Sources:
53Reactome, 12EMD Millipore, 37NCBI BioSystems Database, 29KEGG
See all sources

Pathways related to Intussusception according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Immune response Oncostatin M signaling via JAK-Stat in human cells
Hide members
9.5IL6, VEGFA, CCND1
2
Hide members
9.5ALB, VEGFA, F8
39.4VEGFA, STK11, APC, CCND1
49.4ALB, IL6, CRP
59.2VEGFA, ANGPT2, EPO, IL6
69.2ALB, CFTR, CRP, F8
79.1CCND1, APC, CYR61
88.8CCND1, STK11, VEGFA, ANGPT2, EPO, IL6

Compounds for genes affiliated with Intussusception

About this section
Sources:
44Novoseek, 28IUPHAR, 59Tocris Bioscience, 11DrugBank, 24HMDB, 49PharmGKB
See all sources

Compounds related to Intussusception according to GeneCards/GeneDecks:

(show top 50)    (show all 106)
idCompoundScoreTop Affiliating Genes
1estrogen4410.7F8
2gamma globulin4410.6CRP
3pge24410.5VEGFA
4triamcinolone acetonide44 2811.2CFTR, EPO
5indomethacin44 59 28 1113.1APC, CFTR
6ivig4410.1CRP, CD40LG, F8
7norepinephrine44 11 2412.1APC, F8, CFTR
8citrate phosphate dextrose4410.1F8, EPO
9epinephrine44 11 2412.0CD40LG, CFTR, F8
10tween 80449.9ALB, EPO, F8
11refacto449.9F8, ALB
12iron sucrose449.9IL6, EPO, CRP
13cyclosporin a44 28 5911.9F8, CD40LG, CFTR, ANGPT2
14phenylbutyrate449.9CFTR, EPO, CCND1
15bucillamine449.9IL6, CRP, VEGFA
16rosiglitazone44 49 28 11 2413.8CCND1, IL6
17progestin449.7F8, CCND1, VEGFA, ANGPT2
18pmma449.7CRP, IL6, CD40LG
19heparin44 28 11 2412.7CD40LG, APC, F8, VEGFA
20rituximab44 49 1111.7CD40LG, IL6, CRP, F8
21polysulfone449.7ALB, EPO
22perindopril44 49 1111.7ALB, VEGFA, CRP
23aspartate449.6F8, CD40LG, CFTR, ALB
24infliximab44 49 1111.6CRP, VEGFA, ANGPT2, IL6
25bortezomib44 1110.6VEGFA, CCND1, CD40LG, IL6
26polyethylene glycol449.6CRP, CD40LG, ALB, F8
27vitamin b12449.6EPO, CRP, ALB, CD40LG
28aspirin44 49 28 2412.5CD40LG, F8, CRP, CFTR, APC
29creatinine449.4F8, CRP, ANGPT2, EPO, ALB
30thalidomide44 49 59 1112.4CCND1, CD40LG, EPO, IL6, VEGFA
31ascorbic acid44 2410.4CRP, ALB, CFTR, EPO
32curcumin449.3CFTR, CCND1, APC, VEGFA, IL6
33atorvastatin44 49 28 11 2413.2CD40LG, CRP, IL6, VEGFA
34methotrexate44 49 1111.2IL6, ALB, CCND1, EPO, CRP
35celecoxib44 59 28 49 11 2414.1EPO, ALB, ANGPT2, VEGFA, CCND1, APC
36paraffin449.1CD40LG, CFTR, VEGFA, STK11, APC, CCND1
37fibrinogen449.1CRP, CD40LG, ANGPT2, F8, IL6, ALB
38n acetylcysteine449.1CRP, CCND1, CD40LG, IL6, VEGFA, CFTR
39ly294002449.1IL6, CRP, EPO, ANGPT2, CCND1, VEGFA
40lactate448.9EPO, CRP, ALB, F8, IL6, CD40LG
41vitamin d448.9APC, EPO, IL6, CFTR, ALB
42prostacyclin448.9CRP, F8, APC, VEGFA, CYR61
43prednisolone44 28 1110.8F8, ALB, IL6, CRP
44rapamycin448.8CD40LG, WAS, EPO, CCND1, APC, CRP
45alanine448.7CFTR, ALB, IL6, CD40LG, STK11, F8
46testosterone44 59 11 2411.5CCND1, APC, CRP, CD40LG, EPO, IL6
47folate448.3EPO, CYR61, ALB, APC, CCND1, CRP
48lipid447.9APC, STK11, WAS, CRP, ALB, IL6
49tyrosine447.7APC, WAS, F8, VEGFA, ANGPT2, EPO
50vegf447.6EPO, STK11, VEGFA, ANGPT2, F8, CCND1

GO Terms for genes affiliated with Intussusception

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Intussusception according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.5ALB, VEGFA, F8
2extracellular spaceGO:0056157.9ALB, F8, CRP, VEGFA, ANGPT2, CD40LG
3extracellular regionGO:0055766.9F8, CRP, PRB3, VEGFA, ANGPT2, EPO

Biological processes related to Intussusception according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of epithelial cell proliferation involved in prostate gland developmentGO:06077010.2APC, STK11
2negative regulation of lipid storageGO:0108889.9CRP, IL6
3canonical Wnt receptor signaling pathwayGO:0600709.8STK11, APC, CCND1
4response to estrogen stimulusGO:0436279.8CFTR, EPO, CCND1
5acute-phase responseGO:0069539.8F8, CRP, IL6
6positive regulation of focal adhesion assemblyGO:0518949.6EPB41L5, VEGFA
7platelet degranulationGO:0025769.5F8, VEGFA, ALB
8blood coagulationGO:0075969.2WAS, F8, VEGFA, ANGPT2, ALB
9agingGO:0075689.2IL6, EPO, CRP
10platelet activationGO:0301689.1ALB, IL6, CD40LG, VEGFA, F8
11positive regulation of protein phosphorylationGO:0019348.9CYR61, VEGFA, CCND1
12negative regulation of apoptotic processGO:0430668.3APC, VEGFA, CD40LG, CYR61, IL6, ALB

Products for genes affiliated with Intussusception

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Intussusception

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet