MCID: INV001
MIFTS: 46

Invasive Aspergillosis

Categories: Infectious diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Invasive Aspergillosis

MalaCards integrated aliases for Invasive Aspergillosis:

Name: Invasive Aspergillosis 12 14 69
Aspergillosis Invasive 52

Classifications:



External Ids:

Disease Ontology 12 DOID:0050073

Summaries for Invasive Aspergillosis

Disease Ontology : 12 An aspergillosis that is a serious fungal infection of the lung with pneumonia caused by Aspergillus, which spreads to other parts of the body through bloodstream in patients with acute leukemia and recipients of tissue transplants. Clinical symptoms include pulmonary nodules and hemorrhage.

MalaCards based summary : Invasive Aspergillosis, also known as aspergillosis invasive, is related to lymphoma and legionellosis. An important gene associated with Invasive Aspergillosis is CLEC7A (C-Type Lectin Domain Containing 7A), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Amphotericin B and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and myeloid, and related phenotypes are hematopoietic system and immune system

Related Diseases for Invasive Aspergillosis

Diseases in the Aspergillosis family:

Invasive Aspergillosis

Diseases related to Invasive Aspergillosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 207)
id Related Disease Score Top Affiliating Genes
1 lymphoma 29.4 CD79A IFNG TLR9
2 legionellosis 28.8 CD79A CXCL8 IFNG TLR9
3 rheumatoid arthritis 28.5 CD79A CXCL8 IFNG TLR2 TLR4
4 aspergillosis 11.7
5 bulbospinal polio 10.7 IFNG TLR4
6 ethmoid sinus cancer 10.6 IFNG TLR4
7 malignant renovascular hypertension 10.6 CD79A IFNG
8 total internal ophthalmoplegia 10.6 CLEC7A CXCL8
9 congenital insensitivity to pain with hyperhidrosis 10.6 CXCL8 TLR4
10 lymph node palisaded myofibroblastoma 10.6 CXCL8 MBL2
11 hypercalcinuria macular coloboma 10.6 IFNG TLR4
12 imperforate oropharynx-costo vetebral anomalies 10.6 CD79A MBL2
13 dumping syndrome 10.6 CD79A IFNG
14 gerstmann syndrome 10.6 CABIN1 IFNG
15 gonococcal synovitis 10.5 CLEC7A MBL2 TLR4
16 anti-basement membrane glomerulonephritis 10.5 CD79A CXCL8
17 cholesteatoma of middle ear 10.5 CD79A IFNG
18 chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids 10.5 CD79A IFNG
19 vaginal endometrial stromal sarcoma 10.5 CABIN1 CD79A
20 cardiac tuberculosis 10.5 CD79A CXCL8
21 rickettsialpox 10.5 TLR2 TLR4
22 fallopian tube carcinoma 10.5 CD79A CXCL8
23 mycobacterium malmoense 10.4 CXCL8 TLR2
24 antigen-peptide-transporter 2 deficiency 10.4 TLR2 TLR4
25 esophagus melanoma 10.4 CXCL8 IFNG TLR4
26 oropharyngeal cancer, childhood 10.4 CD79A IFNG
27 basilar artery occlusion 10.4 CD79A TLR6
28 hypertensive heart disease 10.4 TLR2 TLR4
29 amyotrophic lateral sclerosis type 10 10.4 CXCL8 IFNG
30 benign eccrine breast spiradenoma 10.4 CXCL8 IFNG TLR4
31 ragweed sensitivity 10.4 CXCL8 IFNG TLR4
32 blue toe syndrome 10.4 CXCL8 IFNG TLR4
33 mycobacterium xenopi 10.4 CXCL8 TLR2
34 chronic gonorrhea of cervix 10.4 CD79A CLEC7A IFNG
35 b cell linker protein deficiency 10.4 CD79A MBL2
36 plantar wart 10.3 CD79A CXCL8 IFNG
37 alkhurma hemorrhagic fever 10.3 CLEC7A TLR2 TLR4
38 follicular mucinosis 10.3 CD79A CXCL8 TLR4
39 lymphocytic colitis 10.3 CD79A IFNG
40 vocal cord scarring 10.3 CXCL8 IFNG TLR4
41 pasteurellosis 10.3 CXCL8 IFNG
42 dental pulp necrosis 10.3 CXCL10 IFNG
43 prothrombin thrombophilia 10.3 MBL2 TLR2 TLR4
44 askin's tumor 10.3 IFNG MBL2 TLR2
45 neonatal meningitis 10.3 MBL2 TLR2 TLR4
46 leukemia 10.2
47 pellagra 10.2 TLR4 TLR6
48 hematopoietic stem cell transplantation 10.2
49 vulvovaginal candidiasis 10.2 CD79A CXCL8
50 halal setton wang syndrome 10.2 CLEC7A CXCL8 TLR2

Graphical network of the top 20 diseases related to Invasive Aspergillosis:



Diseases related to Invasive Aspergillosis

Symptoms & Phenotypes for Invasive Aspergillosis

MGI Mouse Phenotypes related to Invasive Aspergillosis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.93 SFTPD TLR1 TLR2 TLR4 TLR6 TLR9
2 immune system MP:0005387 9.73 CABIN1 CD79A CLEC7A CXCL10 IFNG MBL2
3 renal/urinary system MP:0005367 9.1 CD79A IFNG MBL2 TLR2 TLR4 TLR9

Drugs & Therapeutics for Invasive Aspergillosis

Drugs for Invasive Aspergillosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 78)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amphotericin B Approved, Investigational Phase 4,Phase 2,Phase 3 1397-89-3 14956 5280965
2
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
3
Voriconazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 137234-62-9 71616
4
Caspofungin Approved Phase 4,Phase 3,Phase 2,Phase 1 179463-17-3, 162808-62-0 468682 2826718
5
Posaconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 171228-49-2 147912
6
Anidulafungin Approved, Investigational Phase 4,Phase 3,Phase 2 166663-25-8 166548
7
Micafungin Approved, Investigational Phase 4,Phase 2 235114-32-6 3081921 477468
8
Itraconazole Approved, Investigational Phase 4 84625-61-6 55283
9
Mycophenolate mofetil Approved, Investigational Phase 4 128794-94-5 5281078
10
Mycophenolic acid Approved Phase 4 24280-93-1 446541
11
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
12 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2
13 Antifungal Agents Phase 4,Phase 3,Phase 2,Phase 1
14 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
15 Antiparasitic Agents Phase 4,Phase 2,Phase 3,Phase 1
16 Antiprotozoal Agents Phase 4,Phase 2,Phase 3,Phase 1
17 Liposomal amphotericin B Phase 4,Phase 2,Phase 3
18 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
19 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
20 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
21 Hormones Phase 4,Phase 3,Phase 2,Phase 1
22 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
23 Steroid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
24 Echinocandins Phase 4,Phase 3,Phase 2,Phase 1
25 Pharmaceutical Solutions Phase 4,Phase 3
26 Cytochrome P-450 CYP2C9 Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
27 glucocorticoids Phase 4,Phase 3
28 Immunosuppressive Agents Phase 4,Phase 1
29 Hydroxyitraconazole Phase 4
30
Midazolam Approved, Illicit Phase 2, Phase 3,Phase 1 59467-70-8 4192
31
deoxycholic acid Approved Phase 3 83-44-3 222528
32
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
33
Fluconazole Approved Phase 3,Phase 1 86386-73-4 3365
34 Amphotericin B, deoxycholate drug combination Phase 3
35 Cholagogues and Choleretics Phase 3
36 Gastrointestinal Agents Phase 3,Phase 1
37 Antiemetics Phase 3
38 Anti-Inflammatory Agents Phase 3
39 Antineoplastic Agents, Hormonal Phase 3
40 Autonomic Agents Phase 3
41 BB 1101 Phase 3
42 Dexamethasone acetate Phase 3 1177-87-3
43 HIV Protease Inhibitors Phase 3
44 Peripheral Nervous System Agents Phase 3
45
protease inhibitors Phase 3
46 Liver Extracts Phase 2
47 Antiviral Agents Phase 2
48 Interferon-gamma Phase 2
49 interferons Phase 2
50 Antibiotics, Antitubercular Phase 2

Interventional clinical trials:

(show top 50) (show all 107)

id Name Status NCT ID Phase Drugs
1 Aspergillus PCR Early Detection in High Risk Oncohematological Patients Unknown status NCT01742026 Phase 4
2 Value of Amphotericin B Inhalation for Prophylaxis of Invasive Pulmonary Aspergillosis After Renal Transplantation Unknown status NCT00986713 Phase 4 Amphotericin B
3 Voriconazole for IPA in Chinese Patients With COPD Unknown status NCT02234739 Phase 4 Voriconazole
4 Efficacy and Safety of Caspofungin for Invasive Pulmonary Aspergillosis Underlying Chronic Obstructive Pulmonary Disease Unknown status NCT01499433 Phase 4 caspofungin
5 COMBISTRAT: AmBisome® in Combination With Caspofungin for the Treatment of Invasive Aspergillosis Completed NCT00334412 Phase 4 Ambisome;caspofungin
6 Acetato de Caspofungin (Cancidas®) in the Treatment of Fungal Infection Completed NCT00388167 Phase 4 Caspofungin
7 A Study of the Efficacy and Safety of Voriconazole for the Treatment of Fungal Infections Completed NCT00647907 Phase 4 Voriconazole
8 King's Invasive Aspergillosis Study II Not yet recruiting NCT02875743 Phase 4 Posaconazole
9 Study to Test the Combination of Voriconazole and Anidulafungin in Patients Who Have, or Are Thought to Have, Invasive Aspergillosis and Who Are Unable to Take a Common Antifungal Therapy (Polyene) Terminated NCT00620074 Phase 4 voriconazole;anidulafungin
10 Post Marketing Study to Evaluate the Efficacy and Safety of Micafungin Treatment on Invasive Aspergillosis Terminated NCT02646774 Phase 4 Micafungin
11 Evaluation of Antifungal Prophylaxis on Graft-versus-host Disease (GVHD) Patients Terminated NCT01282879 Phase 4 Itraconazole
12 A Study to Evaluate the Effectiveness of Voriconazole + Micafungin Versus Voriconazole Alone for Invasive Aspergillosis Withdrawn NCT00423163 Phase 4 micafungin;voriconazole
13 A Multicentre Randomised Controlled Trial Comparing Two Strategies for the Diagnosis of Invasive Aspergillosis in High-risk Haematology Patients Completed NCT00163722 Phase 3
14 Anidulafungin Plus Voriconazole Versus Voriconazole For The Treatment Of Invasive Aspergillosis Completed NCT00531479 Phase 3 voriconazole;anidulafungin;voriconazole
15 A Safety & Effectiveness Study of Intravenous Anidulafungin With AmBisome® for Treatment of Invasive Aspergillosis (IA). Completed NCT00037206 Phase 2, Phase 3 Anidulafungin, VER002
16 Voriconazole vs. Amphotericin B in the Treatment of Invasive Aspergillosis Completed NCT00001646 Phase 3 Voriconazole;Amphotericin B
17 Study Safety/Efficacy of AmBisome Loading Dose Regimen Versus Standard AmBisome Regimen for Initial Treatment Completed NCT00158730 Phase 3 AmBisome
18 Isavuconazole (BAL8557) for Primary Treatment of Invasive Aspergillosis Completed NCT00412893 Phase 3 Isavuconazole;Voriconazole
19 Inhalation of Liposomal Amphotericin B to Prevent Invasive Aspergillosis Completed NCT00263315 Phase 2, Phase 3 nebulised liposomal amphotericin B
20 Comparison of Voriconazole and Amphotericin B in Treating Patients With Aspergillosis Completed NCT00003031 Phase 3 amphotericin B deoxycholate;voriconazole
21 Pharmacokinetic Profiles of Inhaled Lipid Complex Amphotericin B (Abelcet ®) Completed NCT00177684 Phase 3 Amphotericin B
22 Safety and Effectiveness of Granulocyte Transfusions in Resolving Infection in People With Neutropenia (The RING Study) Completed NCT00627393 Phase 3 Standard antimicrobial therapy;G-CSF/dexamethasone
23 Isavuconazole in the Treatment of Renally Impaired Aspergillosis and Rare Fungi Completed NCT00634049 Phase 3 isavuconazole
24 An Open Label, Non-Comparative, Multicenter, Phase III Trial of the Efficacy, Safety and Toleration of Voriconazole in the Primary or Secondary Treatment of Invasive Fungal Infections Completed NCT00001810 Phase 3 Voriconazole
25 Open Label Study of Posaconazole in the Treatment of Invasive Fungal Infections (Study P00041) Completed NCT00034658 Phase 3 Posaconazole
26 Study of Posaconazole in the Treatment of Invasive Fungal Infections (Study P02095) Completed NCT00034632 Phase 3 Posaconazole oral suspension
27 An Open Label, Non-Comparative, Multicenter, Phase III Trial of the Efficacy, Safety and Toleration of Voriconazole in the Primary or Secondary Treatment of Invasive Fungal Infections Completed NCT00001757 Phase 3 Voriconazole
28 A Study of the Safety and Efficacy of Posaconazole Versus Voriconazole for the Treatment of Invasive Aspergillosis (MK-5592-069) Recruiting NCT01782131 Phase 3 Posaconazole;Voriconazole
29 Assessing the Safety and Efficacy of MK-5592 (Posaconazole) in Japanese Participants With Fungal Infection (MK-5592-101) Recruiting NCT02180165 Phase 3 Posaconazole;Voriconazole
30 Caspofungin Acetate or Fluconazole in Preventing Invasive Fungal Infections in Patients With Acute Myeloid Leukemia Who Are Undergoing Chemotherapy Active, not recruiting NCT01307579 Phase 3 caspofungin acetate;fluconazole
31 A Study To Evaluate The Safety Of Voriconazole As Treatment Of Invasive Aspergillosis (Fungal Infection) And Other Rare Molds In Children Terminated NCT00836875 Phase 3 Voriconazole
32 To Determine Whether Galactomannan Test Will Help to Detect Fungal Infections Early and Hence Start Treatment Early Terminated NCT00361517 Phase 3 Amphotericin-B deoxycholate
33 Voriconazole And Anidulafungin Combination For Invasive Aspergillosis In Pediatric Subjects Withdrawn NCT01188759 Phase 3 Voriconazole;Anidulafungin;Voriconazole
34 Prophylaxis With Caspofungin in High-Risk Liver Transplantation Unknown status NCT00333645 Phase 2 Caspofungin
35 Caspofungin Maximum Tolerated Dose in Patients With Invasive Aspergillosis Completed NCT00404092 Phase 2 caspofungin
36 MK0991 in Combination With Standard Antifungal Agent(s) for the Treatment of Salvage Invasive Aspergillosis (0991-037) Completed NCT00076869 Phase 2 MK0991, caspofungin acetate;Comparator: amphotericin B;Comparator: lipid formulation of amphotericin B and/or azole
37 Study of FK463 for the Treatment of Invasive Aspergillosis Completed NCT00036166 Phase 2 FK463
38 Voriconazole With or Without Interferon Gamma in Treating Patients With Aspergillosis or Other Fungal Infections Completed NCT00059878 Phase 2 voriconazole
39 Caspofungin Acetate in Treating Aspergillosis in Patients With Hematologic Cancer or in Patients Who Have Undergone a Stem Cell Transplant Completed NCT00110045 Phase 2 caspofungin acetate
40 Prophylaxis of Fungal Invasive Infections in Leukemia Completed NCT00501098 Phase 2 Caspofungin
41 Nebulized Liposomal Amphotericin B Ambisome for Prophylaxis of Invasive Pulmonary Aspergillosis Completed NCT00391014 Phase 2 liposomal Amphotericine B
42 Nebulized Amphotericin B Lipid Complex in Invasive Pulmonary Aspergillosis in Paediatric Patients With Acute Leukaemia Completed NCT01615809 Phase 2 AMPHOTERICIN B
43 A Study of Caspofungin (MK-0991) in Japanese Children and Adolescents With Documented Candida or Aspergillus Infections (MK-0991-074) Completed NCT01165320 Phase 2 Caspofungin
44 PK/PD Study of Posaconazole for Empiric Treatment of Invasive Fungal Infections in Neutropenic Patients or Treatment of Refractory Invasive Fungal Infections (Study P01893) Completed NCT00034671 Phase 2 Posaconazole oral suspension
45 Study of Isavuconazole Prophylaxis in Adults With Acute Myeloid Leukemia/Myelodysplastic Syndrome (AML/MDS) and Neutropenia Recruiting NCT03019939 Phase 2 Isavuconazole
46 Study on Safety and Pharmacokinetics of Intravenous F901318 for Fungal Prophylaxis in AML Patients Not yet recruiting NCT02856178 Phase 1, Phase 2 F901318;Caspofungin
47 Micafungin Salvage Mono-therapy in Invasive Aspergillosis Terminated NCT00376337 Phase 2 Micafungin;Systemic antifungal therapy
48 Trial of Micafungin (FK463) in Combination With Liposomal Amphotericin B (AmBisome) for Aspergillosis Terminated NCT00047827 Phase 2 Micafungin;Liposomal Amphotericin B
49 Trial of Combination Antifungal Therapy (Vori+Mica vs. Vori+Placebo) in Invasive Aspergillosis Withdrawn NCT01207128 Phase 2 Voriconazole, micafungin
50 F901318 Multiple Ascending Dose Study Completed NCT02342574 Phase 1 F901318;Placebo

Search NIH Clinical Center for Invasive Aspergillosis

Genetic Tests for Invasive Aspergillosis

Anatomical Context for Invasive Aspergillosis

MalaCards organs/tissues related to Invasive Aspergillosis:

39
Lung, Testes, Myeloid, Liver, Bone, Kidney, Bone Marrow

Publications for Invasive Aspergillosis

Articles related to Invasive Aspergillosis:

(show top 50) (show all 648)
id Title Authors Year
1
Cart before the horse: use of Aspergillus PCR to increase the diagnostic yield from BAL in hematological patients at risk of invasive aspergillosis. ( 28573907 )
2017
2
Utility of the serum galactomannan assay for the diagnosis of invasive aspergillosis in children with acute lymphoblastic leukemia. ( 27815226 )
2017
3
Ergot alkaloids contribute to virulence in an insect model of invasive aspergillosis. ( 28827626 )
2017
4
Triazole resistance is still not emerging in A fumigatus isolates causing invasive aspergillosis in Brazilian patients. ( 28893772 )
2017
5
Host immune status-specific production of gliotoxin and bis-methyl-gliotoxin during invasive aspergillosis in mice. ( 28887465 )
2017
6
Long-term follow up of invasive aspergillosis in allogeneic stem cell transplantation recipients and leukemia patients: Differences in risk factors and outcomes. ( 28689016 )
2017
7
The evolving landscape of new diagnostic tests for invasive aspergillosis in hematology patients: strengths and weaknesses. ( 28938246 )
2017
8
Invasive aspergillosis due to Neosartorya aureola in a recipient of kidney transplantation. ( 28705415 )
2017
9
Nosocomial legionellosis and invasive aspergillosis in a child with T-lymphoblastic leukemia. ( 28529020 )
2017
10
Fatal invasive aspergillosis caused by Aspergillus niger after bilateral lung transplantation. ( 28560131 )
2017
11
Invasive Aspergillosis with Disseminated Skin Involvement in a Patient with Acute Myeloid Leukemia: A Rare Case. ( 28626542 )
2017
12
Invasive aspergillosis in a patient with end stage renal disease. ( 28761803 )
2017
13
Voriconazole-refractory invasive aspergillosis. ( 28835093 )
2017
14
Molecular diagnosis of invasive aspergillosis and detection of azole resistance by a newly commercialized PCR kit. ( 28814586 )
2017
15
Cost-Effectiveness Analysis of Isavuconazole vs. Voriconazole as First-Line Treatment for Invasive Aspergillosis. ( 27913989 )
2017
16
Caspofungin Increases Fungal Chitin and Eosinophil and I^I' T Cell-Dependent Pathology in Invasive Aspergillosis. ( 28566368 )
2017
17
Exposure-Response Relationships for Isavuconazole in Patients with Invasive Aspergillosis and Other Filamentous Fungi. ( 28923872 )
2017
18
Effect of involved Aspergillus species on galactomannan in bronchoalveolar lavage of patients with invasive aspergillosis. ( 28693685 )
2017
19
Prospective Biomarker Screening for Diagnosis of Invasive Aspergillosis in High-Risk Pediatric Patients. ( 27795339 )
2017
20
Progressive Dispersion of Azole Resistance in Aspergillus fumigatus: Fatal Invasive Aspergillosis in a Patient with Acute Myeloid Leukemia Infected with an A. fumigatus Strain with a cyp51A TR46 Y121F M172I T289A Allele. ( 28743702 )
2017
21
Drug-drug interactions between triazole antifungal agents used to treat invasive aspergillosis and immunosuppressants metabolized by cytochrome P450 3A4. ( 28722255 )
2017
22
Invasive aspergillosis in acute myeloid leukemia: Are we making progress in reducing mortality? ( 27915304 )
2017
23
Evaluation of serum galactomannan enzyme immunoassay at two different cut-offs for the diagnosis of invasive aspergillosis in patients with febrile neutropenia. ( 28681812 )
2017
24
Invasive Aspergillosis of the Abdominal Aorta with Multiple Peripheral Embolic Lesions. ( 28567096 )
2017
25
Lateral Flow Assays for the Diagnosis of Invasive Aspergillosis: Current Status. ( 28680526 )
2017
26
A computational model of invasive aspergillosis in the lung and the role of iron. ( 27098278 )
2016
27
Invasive Aspergillosis in Hematological Patients. ( 27251320 )
2016
28
Invasive aspergillosis successfully treated by combined antifungal therapy and immunosuppressive monotherapy two months following heart transplantation. ( 27516796 )
2016
29
Delay of antifungal therapy influences the outcome of invasive aspergillosis in experimental models of infection. ( 27231274 )
2016
30
A retrospective study of the epidemiology and clinical manifestation of invasive aspergillosis in a major tertiary care hospital in Bahrain. ( 27033677 )
2016
31
Aspergillus march: from ABPA to aspergilloma to subacute invasive aspergillosis. ( 27980539 )
2016
32
Orbital Apex Syndrome Caused by Invasive Aspergillosis as an Adverse Effect of Systemic Chemotherapy for Metastatic Colorectal Cancer: a Case Report. ( 26851046 )
2016
33
Proteomic Profiling of Serological Responses to Aspergillus fumigatus Antigens in Patients with Invasive Aspergillosis. ( 26974881 )
2016
34
Improving case finding of invasive aspergillosis in children using string searches. ( 27375058 )
2016
35
Prognosis of Invasive Aspergillosis in Kidney Transplant Recipients: A Case-Control Study. ( 27819031 )
2016
36
Guideline recommendations for the prophylaxis of invasive aspergillosis in AML. ( 27930638 )
2016
37
The Plasmair Decontamination System Is Protective Against Invasive Aspergillosis in Neutropenic Patients. ( 27340735 )
2016
38
Invasive Aspergillosis of the Stomach and Co-infection With Candida krusei in a Patient With Terminal Liver Failure: A Case Report. ( 27932169 )
2016
39
Common Genetic Polymorphisms within NFI_B-Related Genes and the Risk of Developing Invasive Aspergillosis. ( 27570521 )
2016
40
Development and evaluation of enzyme-linked immunosorbent assay of nucleic acid sequence-based amplification for diagnosis of invasive aspergillosis. ( 27714704 )
2016
41
Galactomannan testing and Aspergillus PCR in same-day bronchoalveolar lavage and blood samples for diagnosis of invasive aspergillosis. ( 27744310 )
2016
42
Neonatal Cutaneous Invasive Aspergillosis Accompanied by Hemophagocytic Lymphohistocytosis. ( 27977554 )
2016
43
Management of invasive Aspergillosis in acute myelogenous leukemia. ( 27379944 )
2016
44
Isavuconazonium sulfate: a new agent for the treatment of invasive aspergillosis and invasive mucormycosis. ( 27160418 )
2016
45
Aspergillus PCR in serum for the diagnosis, follow-up and prognosis of invasive aspergillosis in neutropenic and nonneutropenic patients. ( 26899830 )
2016
46
Sequential Sonographic Features of Primary Invasive Aspergillosis Involving Only the Thyroid Gland: A Case Report and Literature Review. ( 27110341 )
2016
47
Domestic mould exposure and invasive aspergillosis-air sampling of Aspergillus spp. spores in homes of hematological patients, a pilot study. ( 26941254 )
2016
48
Polymorphisms in Host Immunity-Modulating Genes and Risk of Invasive Aspergillosis: Results from the AspBIOmics Consortium. ( 26667837 )
2016
49
Isavuconazole: A Review in Invasive Aspergillosis and Mucormycosis. ( 27766566 )
2016
50
Isavuconazole in the treatment of invasive aspergillosis and mucormycosis infections. ( 27330318 )
2016

Variations for Invasive Aspergillosis

Expression for Invasive Aspergillosis

Search GEO for disease gene expression data for Invasive Aspergillosis.

Pathways for Invasive Aspergillosis

Pathways related to Invasive Aspergillosis according to GeneCards Suite gene sharing:

(show all 30)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.89 CD79A CLEC7A CXCL10 CXCL8 IFNG MBL2
2
Show member pathways
13.31 CXCL10 CXCL8 TLR1 TLR2 TLR4 TLR6
3
Show member pathways
13.12 CD79A IFNG TLR1 TLR2 TLR4 TLR6
4
Show member pathways
12.91 CLEC7A CXCL8 TLR1 TLR2 TLR4 TLR6
5
Show member pathways
12.71 CXCL10 CXCL8 IFNG TLR2 TLR4 TLR9
6
Show member pathways
12.61 TLR1 TLR2 TLR4 TLR6 TLR9
7
Show member pathways
12.54 TLR1 TLR2 TLR4 TLR6 TLR9
8
Show member pathways
12.43 CXCL10 CXCL8 IFNG MBL2 SFTPD TLR1
9
Show member pathways
12.39 TLR1 TLR2 TLR4 TLR6
10
Show member pathways
12.26 CXCL10 CXCL8 IFNG TLR2
11 12.25 CABIN1 CD79A CXCL10 IFNG TLR1 TLR2
12 12.17 IFNG TLR1 TLR2 TLR4 TLR6 TLR9
13 12.12 CLEC7A MBL2 SFTPD TLR2 TLR4 TLR6
14 12.05 CLEC7A IFNG TLR1 TLR2 TLR4 TLR6
15 12.04 TLR1 TLR2 TLR4 TLR6 TLR9
16
Show member pathways
11.99 TLR1 TLR2 TLR4 TLR6 TLR9
17 11.96 CXCL10 CXCL8 IFNG TLR4
18
Show member pathways
11.91 IFNG TLR1 TLR2 TLR4 TLR6 TLR9
19 11.85 CXCL8 IFNG TLR2 TLR4
20
Show member pathways
11.85 IFNG TLR1 TLR2 TLR4 TLR6 TLR9
21 11.8 CXCL8 IFNG TLR2 TLR4
22 11.76 CXCL8 IFNG TLR4
23 11.73 CLEC7A TLR1 TLR2 TLR4 TLR6 TLR9
24
Show member pathways
11.69 CABIN1 CXCL8 IFNG
25 11.65 TLR2 TLR4 TLR9
26 11.54 CXCL8 TLR2 TLR4
27 11.52 CXCL8 IFNG TLR2 TLR4 TLR9
28
Show member pathways
11.49 CXCL10 CXCL8 IFNG SFTPD TLR1 TLR2
29 11.46 IFNG TLR2 TLR4
30 11.15 IFNG TLR1 TLR2

GO Terms for Invasive Aspergillosis

Cellular components related to Invasive Aspergillosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.56 CD79A CXCL10 IFNG TLR4
2 phagocytic vesicle membrane GO:0030670 9.33 TLR1 TLR2 TLR6
3 membrane raft GO:0045121 9.26 CD79A TLR1 TLR2 TLR6
4 Toll-like receptor 1-Toll-like receptor 2 protein complex GO:0035354 8.62 TLR1 TLR2

Biological processes related to Invasive Aspergillosis according to GeneCards Suite gene sharing:

(show top 50) (show all 54)
id Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.99 CABIN1 CD79A CXCL10 IFNG
2 positive regulation of gene expression GO:0010628 9.93 IFNG TLR2 TLR4 TLR9
3 cellular response to lipopolysaccharide GO:0071222 9.92 CXCL10 CXCL8 IFNG TLR4
4 inflammatory response GO:0006954 9.92 CLEC7A CXCL10 CXCL8 TLR1 TLR2 TLR4
5 defense response to bacterium GO:0042742 9.91 IFNG MBL2 SFTPD TLR1 TLR4 TLR6
6 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.89 TLR4 TLR6 TLR9
7 defense response GO:0006952 9.89 CXCL10 CXCL8 TLR1
8 positive regulation of inflammatory response GO:0050729 9.85 TLR2 TLR4 TLR9
9 positive regulation of interleukin-6 production GO:0032755 9.85 TLR2 TLR4 TLR9
10 immune system process GO:0002376 9.81 CD79A CLEC7A MBL2 SFTPD TLR1 TLR2
11 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.8 TLR2 TLR4 TLR9
12 positive regulation of tumor necrosis factor production GO:0032760 9.8 IFNG TLR2 TLR4 TLR9
13 positive regulation of interleukin-8 production GO:0032757 9.77 TLR2 TLR4 TLR9
14 positive regulation of interferon-beta production GO:0032728 9.76 TLR2 TLR4 TLR9
15 positive regulation of interleukin-10 production GO:0032733 9.75 TLR2 TLR4 TLR9
16 positive regulation of NF-kappaB import into nucleus GO:0042346 9.74 TLR2 TLR4 TLR9
17 positive regulation of chemokine production GO:0032722 9.73 TLR2 TLR4 TLR9
18 positive regulation of interleukin-12 production GO:0032735 9.73 IFNG TLR2 TLR4 TLR9
19 cell activation GO:0001775 9.72 TLR1 TLR2 TLR6
20 defense response to protozoan GO:0042832 9.71 CLEC7A IFNG
21 negative regulation of growth of symbiont in host GO:0044130 9.71 IFNG MBL2
22 microglial cell activation GO:0001774 9.71 TLR2 TLR6
23 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.71 TLR2 TLR4 TLR9
24 T-helper 1 type immune response GO:0042088 9.7 TLR4 TLR6
25 positive regulation of tumor necrosis factor biosynthetic process GO:0042535 9.7 TLR1 TLR4
26 negative regulation of interleukin-17 production GO:0032700 9.7 IFNG TLR4
27 cellular response to lipoteichoic acid GO:0071223 9.7 TLR2 TLR4
28 response to molecule of bacterial origin GO:0002237 9.7 CXCL8 TLR2 TLR9
29 macrophage activation GO:0042116 9.69 TLR1 TLR4
30 interleukin-1 beta secretion GO:0050702 9.69 TLR4 TLR6
31 I-kappaB phosphorylation GO:0007252 9.69 TLR2 TLR4 TLR9
32 positive regulation of MHC class II biosynthetic process GO:0045348 9.68 IFNG TLR4
33 positive regulation of interferon-beta biosynthetic process GO:0045359 9.68 TLR4 TLR9
34 positive regulation of interleukin-12 biosynthetic process GO:0045084 9.68 IFNG TLR4
35 positive regulation of NLRP3 inflammasome complex assembly GO:1900227 9.67 TLR4 TLR6
36 positive regulation of interleukin-18 production GO:0032741 9.67 TLR2 TLR9
37 toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 9.66 TLR2 TLR6
38 positive regulation of toll-like receptor signaling pathway GO:0034123 9.65 TLR2 TLR9
39 cellular response to diacyl bacterial lipopeptide GO:0071726 9.65 TLR2 TLR6
40 positive regulation of nitric oxide biosynthetic process GO:0045429 9.65 IFNG TLR4
41 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.65 IFNG TLR1 TLR6
42 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.65 TLR1 TLR2 TLR4 TLR6 TLR9
43 cellular response to triacyl bacterial lipopeptide GO:0071727 9.64 TLR1 TLR2
44 toll-like receptor TLR1:TLR2 signaling pathway GO:0038123 9.64 TLR1 TLR2
45 nitric oxide metabolic process GO:0046209 9.63 TLR2 TLR6
46 detection of triacyl bacterial lipopeptide GO:0042495 9.61 TLR1 TLR2
47 detection of diacyl bacterial lipopeptide GO:0042496 9.61 TLR2 TLR6
48 response to bacterial lipoprotein GO:0032493 9.6 TLR2 TLR6
49 toll-like receptor signaling pathway GO:0002224 9.43 SFTPD TLR1 TLR2 TLR4 TLR6 TLR9
50 tumor necrosis factor production GO:0032640 9.36 TLR9

Molecular functions related to Invasive Aspergillosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 receptor activity GO:0004872 9.62 TLR1 TLR2 TLR4 TLR6
2 receptor binding GO:0005102 9.4 CXCL10 MBL2
3 signaling pattern recognition receptor activity GO:0008329 9.37 CLEC7A TLR2
4 transmembrane signaling receptor activity GO:0004888 9.35 CD79A TLR1 TLR4 TLR6 TLR9
5 lipopolysaccharide receptor activity GO:0001875 9.26 TLR2 TLR4
6 Toll-like receptor 2 binding GO:0035663 9.16 TLR1 TLR6
7 lipopeptide binding GO:0071723 8.8 TLR1 TLR2 TLR6

Sources for Invasive Aspergillosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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