MCID: INV001
MIFTS: 49

Invasive Aspergillosis malady

Summaries for Invasive Aspergillosis

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 An aspergillosis that is a serious fungal infection of the lung with pneumonia caused by aspergillus, which spreads to other parts of the body through bloodstream in patients with acute leukemia and recipients of tissue transplants. clinical symptoms include pulmonary nodules and hemorrhage.

MalaCards: Invasive Aspergillosis, also known as aspergillosis, invasive, is related to aspergillosis and acute leukemia. An important gene associated with Invasive Aspergillosis is CLEC7A (C-type lectin domain family 7, member A), and among its related pathways are Th17 Differentiation and Immune response Bacterial infections in normal airways. The compounds endotoxin and glucose have been mentioned in the context of this disorder. Affiliated tissues include lung, liver and myeloid, and related mouse phenotypes are renal/urinary system and homeostasis/metabolism.

Aliases & Classifications for Invasive Aspergillosis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS
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Aliases & Descriptions:

invasive aspergillosis 8 10
aspergillosis, invasive 60
aspergillosis invasive 44


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Disease Ontology8 DOID:0050073

Related Diseases for Invasive Aspergillosis

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17GeneCards, 18GeneDecks
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Diseases related to Invasive Aspergillosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 155)
idRelated DiseaseScoreTop Affiliating Genes
1aspergillosis32.0CD79A, MBL2, SFTPD, TLR4
2acute leukemia30.9CSF3, IL17A, TPMT
3leukemia30.8TLR4, MBL2, CSF3, CD79A, HBB, IL17A
4candidiasis30.6CD79A
5neutropenia30.5MBL2, CSF3, CXCL10, TPMT
6pneumonia30.5TLR4, SFTPD, MBL2, CSF3, CD79A, CXCL10
7hepatitis30.4CXCL10
8pancreatitis30.2TPMT
9lupus erythematosus30.2CD79A
10influenza30.2SFTPD, MBL3P, MBL2, CD79A, CXCL10
11cystic fibrosis30.2TLR4, SFTPD, MBL2, HBB, IL17A
12systemic lupus erythematosus30.2TLR4, MBL2, CD79A, CXCL10, IL17A, TPMT
13amyloidosis30.0CD79A
14allergic bronchopulmonary aspergillosis30.0SFTPD, MBL2
15hepatitis c30.0TLR4, CXCL10
16thyroiditis30.0MBL2, CD79A
17adenocarcinoma30.0SFTPD, CXCL10, PLG
18hematologic cancer30.0CSF3
19arthritis30.0TLR4, HBB, CXCL10, IL17A, PLG
20rheumatoid arthritis30.0TLR4, SFTPD, MBL2, CD79A, CXCL10, IL17A
21tuberculosis30.0TLR4, TLR1, SFTPD, MBL2, CD79A, HBB
22chronic granulomatous disease10.5
23acute myeloid leukemia10.4
24myeloid leukemia10.4
25non-hodgkin lymphoma10.2
26hepatitis a10.2
27lymphoblastic leukemia10.2
28ophthalmoplegia10.2
29graft versus host disease10.0
30acute thyroiditis10.0
31pearson syndrome10.0
32acute pancreatitis10.0
33antiphospholipid syndrome10.0
34multidrug-resistant tuberculosis10.0
35toxic megacolon10.0
36dengue shock syndrome10.0
37pulmonary aspergilloma10.0
38cerebritis10.0
39cushing's syndrome10.0
40carotid artery thrombosis10.0
41melas syndrome10.0
42autoimmune hemolytic anemia10.0
43autoimmune hepatitis10.0
44pyoderma gangrenosum10.0
45temporal arteritis10.0
46alcoholic hepatitis10.0
47aortic aneurysm10.0
48aplastic anemia10.0
49autosomal recessive disease10.0
50endocarditis10.0

Graphical network of the top 20 diseases related to Invasive Aspergillosis:



Diseases related to invasive aspergillosis

Clinical Features for Invasive Aspergillosis

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Drugs & Therapeutics for Invasive Aspergillosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Invasive Aspergillosis

Drug clinical trials:

Search ClinicalTrials for Invasive Aspergillosis

Search NIH Clinical Center for Invasive Aspergillosis

Search CenterWatch for Invasive Aspergillosis

Genetic Tests for Invasive Aspergillosis

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Anatomical Context for Invasive Aspergillosis

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32MalaCards
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MalaCards organs/tissues related to Invasive Aspergillosis:

32
Lung, Liver, Myeloid, Testes, Bone marrow, Bone, Kidney, T cells, Heart, Colon, Brain, Whole blood, Skin, Breast, Thyroid, Endothelial

Animal Models for Invasive Aspergillosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Invasive Aspergillosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.4TLR4, HBB, IL17A, PLG
2MP:00053768.2SFTPD, MBL2, CD79A, HBB, CLEC7A, CXCL10
3MP:00053977.8TLR4, SFTPD, MBL2, CSF3, CD79A, HBB
4MP:00053877.2PLG, CABIN1, TLR4, TLR6, TLR1, SFTPD

Publications for Invasive Aspergillosis

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50PubMed
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Articles related to Invasive Aspergillosis:

(show top 50)    (show all 640)
idTitleAuthorsYear
1
Renal Infarction Secondary to Invasive Aspergillosis in a 5-Year-Old Girl With Acute Lymphoblastic Leukemia. (24136022)
2013
2
Early diagnosis of invasive pulmonary aspergillosis in hematologic patients: an opportunity to improve the outcome. (24186309)
2013
3
Combined real-time PCR and galactomannan surveillance improves diagnosis of invasive aspergillosis in high risk patients with haematological malignancies. (23614624)
2013
4
Atypical presentation of invasive pulmonary aspergillosis in a liver transplant recipient. (23792526)
2013
5
Invasive aspergillosis in intensive care unit patients in Iran. (24069658)
2013
6
Serum galactomannan assay for the diagnosis of invasive aspergillosis in children with haematological malignancies. (23369047)
2013
7
Acute Chiasmal Abscess Resulting from Perineural Extension of Invasive Sino-Orbital Aspergillosis in an Immunocompetent Patient. (23973515)
2013
8
Current treatment options for invasive aspergillosis. (23527325)
2013
9
Early diagnosis and treatment of invasive pulmonary aspergillosis in a patient with cystic fibrosis. (24248318)
2013
10
The role of combination antifungal therapy in the treatment of invasive aspergillosis: a systematic review. (22137271)
2012
11
A near fatal case of invasive aspergillosis. (23569520)
2012
12
Voriconazole-induced pancreatitis in a patient of acute myeloid leukemia and invasive aspergillosis. (22713708)
2012
13
Pharmacodynamics of voriconazole in a dynamic in vitro model of invasive pulmonary aspergillosis: implications for in vitro susceptibility breakpoints. (22634880)
2012
14
Surgical excision of invasive aspergillosis of the right ventricle presenting as intractable ventricular arrhythmia and right ventricular mass. (22958999)
2012
15
Azole-resistant invasive aspergillosis in a patient with acute myeloid leukaemia in Germany. (22971327)
2012
16
Pulseless right upper limb: an unusual manifestation of invasive pulmonary aspergillosis in acute myeloid leukemia. (22715561)
2012
17
Early diagnosis of invasive pulmonary aspergillosis in a young immunocompetent patient. (22378557)
2012
18
Prospective evaluation of clinical and biological markers to predict the outcome of invasive pulmonary aspergillosis in hematological patients. (22170907)
2012
19
Early serum galactomannan trend as a predictor of outcome of invasive aspergillosis. (22553232)
2012
20
Impact of the revised (2008) EORTC/MSG definitions for invasive fungal disease on the rates of diagnosis of invasive aspergillosis. (22074309)
2012
21
Therapy with antifungals decreases the diagnostic performance of PCR for diagnosing invasive aspergillosis in bronchoalveolar lavage samples of patients with haematological malignancies. (22740590)
2012
22
DIGE enables the detection of a putative serum biomarker of fungal origin in a mouse model of invasive aspergillosis. (22370163)
2012
23
Breakthrough lung Scedosporium prolificans infection with multiple cavity lesions in a patient receiving voriconazole for probable invasive aspergillosis associated with monoclonal gammopathy of undetermined significance (MGUS). (21441711)
2011
24
Design issues in a randomized controlled trial of a pre-emptive versus empiric antifungal strategy for invasive aspergillosis in patients with high-risk hematologic malignancies. (21281234)
2011
25
Current issues in the clinical management of invasive aspergillosis--the AGIHO, DMykG, A9GMM and PEG web-based survey and expert consensus conference 2009. (21518025)
2011
26
Prophylaxis and treatment of invasive aspergillosis with voriconazole, posaconazole and caspofungin: review of the literature. (21486728)
2011
27
Invasive aspergillosis in developing countries. (20718613)
2011
28
Invasive aspergillosis promotes tumor growth and severity in a tumor-bearing mouse model. (20921987)
2010
29
Invasive aspergillosis in two liver transplant recipients: diagnosis by SeptiFast. (19210691)
2009
30
How invasive aspergillosis may have a beneficial effect after single lung transplantation. (19670566)
2009
31
Detection of Aspergillus DNA by a nested PCR assay is able to improve the diagnosis of invasive aspergillosis in paediatric patients. (19541789)
2009
32
The role of bronchoalveolar lavage galactomannan in the diagnosis of pediatric invasive aspergillosis. (19238113)
2009
33
Correlation between high-resolution computed tomography and galactomannan antigenemia in adult hematologic patients at risk for invasive aspergillosis. (18468830)
2009
34
Invasive aspergillosis of pulmonary hydatid cyst. (19139611)
2009
35
Clinical trial design for invasive aspergillosis: time to cast a different mold. (19253146)
2009
36
Invasive pulmonary infection due to Trichoderma longibrachiatum mimicking invasive Aspergillosis in a neutropenic patient successfully treated with voriconazole combined with caspofungin. (18419477)
2008
37
Images in HIV/AIDS. Invasive aspergillosis presenting as a neck mass in a person with HIV/AIDS. (17672013)
2007
38
Disseminated invasive aspergillosis with cerebral involvement successfully treated with caspofungin and voriconazole. (17721739)
2007
39
Invasive aspergillosis localised to the colon presenting as toxic megacolon. (17328784)
2007
40
Invasive nosocomial aspergillosis associated with heart failure and complete heart block following recovery from dengue shock syndrome. (17545933)
2007
41
Invasive aspergillosis associated with bevacizumab, a vascular endothelial growth factor inhibitor. (17336567)
2007
42
Invasive aspergillosis in a tertiary-care hospital in Thailand. (17596043)
2007
43
Survival after disseminated invasive aspergillosis in a multivisceral transplant recipient. (17275530)
2007
44
Protective role of mannan-binding lectin in a murine model of invasive pulmonary aspergillosis. (17335555)
2007
45
Invasive aspergillosis of the paranasal sinuses and the skull base. (17534639)
2007
46
Primary invasive aspergillosis of the digestive tract: report of two cases and review of the literature. (17180588)
2006
47
Invasive aspergillosis causing small bowel infarction in a patient of carcinoma breast undergoing chemotherapy. (16753069)
2006
48
Sequential or combination antifungal therapy with voriconazole and liposomal amphotericin B in a Guinea pig model of invasive aspergillosis. (16569887)
2006
49
Can combination salvage therapy for invasive aspergillosis improve patient outcome? (16264929)
2005
50
Invasive aspergillosis producing painful ophthalmoplegia. (16459537)
2005

Genetic Variations for Invasive Aspergillosis

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Expression for genes affiliated with Invasive Aspergillosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Invasive Aspergillosis

Search GEO for disease gene expression data for Invasive Aspergillosis.

Pathways for genes affiliated with Invasive Aspergillosis

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52R&D Systems, 53Reactome, 51QIAGEN, 59Tocris Bioscience, 4Cell Signaling Technology, 29KEGG, 12EMD Millipore, 37NCBI BioSystems Database
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Pathways related to Invasive Aspergillosis according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.1TLR6, TLR1
2
Immune response Bacterial infections in normal airways
9.8SFTPD, TLR1, TLR4
3
Hide members
9.8TLR1, TLR6, TLR4
49.8TLR4, TLR6, TLR1
59.8TLR4, TLR6, TLR1
69.6CLEC7A, TLR1, TLR6, TLR4
79.6TLR4, TLR6, TLR1, CLEC7A
8
Hide members
9.6TLR4, TLR6, TLR1, CLEC7A
99.6CXCL10, TLR1, TLR6, TLR4
10
Hide members
9.6CXCL10, TLR1, TLR6, TLR4
11
Hide members
9.6TLR4, TLR6, TLR1, IL17A
12
Hide members
9.5CD79A, TLR1, TLR6, TLR4
13
Cytokine production by Th17 cells in CF (Mouse model)
9.4IL17A, CSF3, TLR4
149.4CLEC7A, MBL2, SFTPD, TLR6, TLR4
159.4HBB, CSF3, TLR4
16
Hide members
9.1TLR4, TLR6, TLR1, CSF3, CXCL10

Compounds for genes affiliated with Invasive Aspergillosis

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB, 2BitterDB, 24HMDB
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Compounds related to Invasive Aspergillosis according to GeneCards/GeneDecks:

(show all 48)
idCompoundScoreTop Affiliating Genes
1endotoxin4410.4CSF3
2glucose4410.3CLEC7A, SFTPD
3pam2csk45910.2TLR4, TLR6, TLR1
4pam3csk45910.2TLR4, TLR6, TLR1
5poly(i:c)5910.2TLR4, TLR6, TLR1
6resiquimod44 5911.2TLR4, TLR6, TLR1
7zymosan4410.2TLR4, MBL2, CLEC7A
8flagellin44 2811.2TLR1, TLR6, TLR4
9imiquimod44 28 59 1113.2TLR1, TLR6, TLR4
10lipoteichoic acid4410.1TLR4, TLR1, MBL2
11infliximab44 49 1112.0IL17A, CXCL10, TLR4
12prednisolone44 28 1112.0SFTPD, MBL2, CD79A, TPMT
13peptidoglycan44 2811.0MBL2, TLR1, TLR6, TLR4
14neopterin4410.0CXCL10, CD79A, MBL2
15ifn-alpha4410.0IL17A, CXCL10, TLR4
16tuberculin4410.0CD79A, MBL2
17n-acetylglucosamine4410.0MBL2, MBL3P, SFTPD
18dexamethasone44 49 28 1113.0TLR4, SFTPD, CD79A, CLEC7A
19pneumococcal4410.0CD79A, TLR4
20allergens449.9TLR4, SFTPD, CD79A, CXCL10
21chloroquine44 2 49 28 1113.8TLR4, CD79A, CXCL10
22ribavirin44 49 1111.8MBL2, CSF3, CXCL10
23azathioprine44 49 2 1112.8CABIN1, CD79A, HBB, TPMT
24ccl344 2810.7TLR4, CSF3, CXCL10
25rantes449.7TLR4, MBL2, CSF3, IL17A
26histamine44 28 2411.6TLR4, SFTPD, CD79A, CXCL10, TPMT
27suramin44 28 1111.6PLG, CXCL10, CD79A
28mycophenolate mofetil44 49 1111.6TPMT, CD79A, CSF3, CABIN1
29vitamin d449.6TLR4, MBL2, CD79A, CXCL10
30estrogen449.6MBL2, SSBP3, CD79A
31creatinine449.6MBL2, CD79A, CXCL10, IL17A, TPMT
32polysaccharide449.5TLR4, SFTPD, MBL3P, MBL2, CD79A
33methotrexate44 49 1111.5TPMT, IL17A, CD79A, CSF3
34fibrinogen449.5TLR4, MBL2, CD79A, PLG
35anti-fungal449.4TLR4, SFTPD, MBL2, CSF3, CD79A
36tacrolimus44 49 1111.4CABIN1, TLR4, CD79A, CXCL10, IL17A, TPMT
37mannan449.4IL17A, CD79A, MBL2, MBL3P, SFTPD, TLR4
38mannose449.2TLR4, SFTPD, MBL3P, MBL2, CD79A, CLEC7A
39thymidine44 2410.2SFTPD, CSF3, HBB, CXCL10, IL17A, PLG
40lipid449.1TLR4, TLR6, TLR1, SFTPD, MBL2, CXCL10
41cyclosporin a44 28 5911.1CABIN1, TLR4, CSF3, CD79A, IL17A, TPMT
42steroid449.0CABIN1, SFTPD, MBL2, CD79A, HBB, IL17A
43nitric oxide44 11 2411.0CABIN1, TLR4, SFTPD, MBL2, HBB, CXCL10
44vegf448.9TLR4, MBL2, CSF3, CD79A, CXCL10, IL17A
45atp44 289.8TLR4, MBL2, SSBP3, HBB, CXCL10, PLG
46cysteine448.7TLR4, SFTPD, MBL2, SSBP3, CD79A, HBB
47tyrosine448.5TLR4, MBL2, CSF3, HBB, CLEC7A, CXCL10
48serine448.5TLR4, MBL3P, SSBP3, HBB, PLG

GO Terms for genes affiliated with Invasive Aspergillosis

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16Gene Ontology
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Cellular components related to Invasive Aspergillosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.0IL17A, CXCL10, CLEC7A, CD79A, TLR4
2extracellular spaceGO:0056158.9MBL2, CSF3, CXCL10, IL17A, PLG, SFTPD

Biological processes related to Invasive Aspergillosis according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1toll-like receptor 6 signaling pathwayGO:03415010.3TLR1, TLR6
2detection of diacyl bacterial lipopeptideGO:04249610.2TLR1, TLR6
3positive regulation of interleukin-6 biosynthetic processGO:04541010.2TLR6, TLR1
4positive regulation of phagocytosisGO:05076610.1CLEC7A, MBL2, SFTPD
5regulation of cytokine secretionGO:05070710.1TLR1, TLR6, TLR4
6T-helper 1 type immune responseGO:04208810.0TLR4, TLR6, TLR1
7macrophage activationGO:04211610.0TLR1, TLR4
8defense response to bacteriumGO:0427429.8MBL2, TLR6, TLR4
9positive regulation of tumor necrosis factor biosynthetic processGO:0425359.7TLR1, TLR4
10MyD88-dependent toll-like receptor signaling pathwayGO:0027559.7TLR4, TLR6, TLR1
11inflammatory responseGO:0069549.6TLR6, TLR1, CLEC7A, CXCL10, IL17A
12innate immune responseGO:0450879.4TLR4, TLR6, TLR1, SFTPD, MBL2, CLEC7A
13immune responseGO:0069559.1TLR4, TLR6, TLR1, CSF3, CXCL10, IL17A

Molecular functions related to Invasive Aspergillosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane signaling receptor activityGO:0048889.5CD79A, TLR1, TLR6, TLR4

Products for genes affiliated with Invasive Aspergillosis

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Sources for Invasive Aspergillosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet