MCID: INV001
MIFTS: 53

Invasive Aspergillosis malady

Infectious diseases category
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Summaries for Invasive Aspergillosis

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Disease Ontology:8 An aspergillosis that is a serious fungal infection of the lung with pneumonia caused by aspergillus, which spreads to other parts of the body through bloodstream in patients with acute leukemia and recipients of tissue transplants. clinical symptoms include pulmonary nodules and hemorrhage.

MalaCards based summary: Invasive Aspergillosis, also known as aspergillosis, invasive, is related to aspergillosis and chronic obstructive pulmonary disease. An important gene associated with Invasive Aspergillosis is CLEC7A (C-type lectin domain family 7, member A), and among its related pathways are TRAF Pathway and MAPK Pathway. The compounds poly(i:c) and pam3csk4 have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and liver, and related mouse phenotypes are digestive/alimentary and respiratory system.

Aliases & Classifications for Invasive Aspergillosis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS
See all sources

Invasive Aspergillosis, Aliases & Descriptions:

Name: Invasive Aspergillosis 8 10
Aspergillosis, Invasive 62
 
Aspergillosis Invasive 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


External Ids:

Disease Ontology8 DOID:0050073

Related Diseases for Invasive Aspergillosis

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Diseases related to Invasive Aspergillosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 142)
idRelated DiseaseScoreTop Affiliating Genes
1aspergillosis31.7TLR4, SFTPD, IFNG, MBL2, CD79A
2chronic obstructive pulmonary disease30.8SFTPD, IL17A, CXCL10
3neutropenia30.7TPMT, CSF3, MBL2, CXCL10
4thyroiditis30.7MBL2, CD79A
5candidiasis30.6IFNG, PLB1, CD79A
6acute leukemia30.4TPMT, IL17A, CSF3
7septic shock30.1CSF3, TLR4, MBL2
8cystic fibrosis30.1MBL2, SFTPD, HBB, IL17A, TLR4
9hepatitis c30.0IFNG, TLR4, CXCL10
10pneumonia29.9CD79A, IL17A, CXCL10, SFTPD, TLR4, MBL2
11influenza29.9SFTPD, CXCL10, IFNG, MBL3P, MBL2, CD79A
12colitis29.8CXCL10, IL17A, IFNG, TLR4
13sepsis29.7PLG, TLR4, CSF3, MBL2, TLR1, SFTPD
14systemic lupus erythematosus29.4TLR4, CD79A, MBL2, IL17A, IFNG, TPMT
15ulcerative colitis29.4TLR4, TPMT, CXCL10, IFNG, IL17A, CD79A
16leukemia29.3CSF3, TPMT, PLG, CD79A, MBL2, IL17A
17arthritis29.3PLG, TLR4, CXCL10, IFNG, HBB, IL17A
18rheumatoid arthritis28.8SFTPD, TPMT, CXCL10, IFNG, IL17A, PLG
19tuberculosis28.7IFNG, SFTPD, HBB, CXCL10, CLEC7A, IL17A
20hematopoietic stem cell transplantation10.7
21coccidioidomycosis10.6CLEC7A
22chronic granulomatous disease10.5
23toxoplasmosis10.5CD79A
24acute myeloid leukemia10.5
25myeloid leukemia10.5
26q fever10.5CD79A
27bronchiolitis10.4TLR4
28allergic bronchopulmonary aspergillosis10.4MBL2, SFTPD
29acute poststreptococcal glomerulonephritis10.4CD79A
30collagen disease10.4SFTPD, MBL2
31cryptosporidiosis10.4CD79A, MBL2
32encephalitis10.4CXCL10, IL17A
33immunoglobulin g deficiency10.4MBL2, CD79A
34mesangial proliferative glomerulonephritis10.4CD79A, MBL2
35immunoglobulin alpha deficiency10.4CD79A, MBL2
36allergic contact dermatitis10.3IL17A, CXCL10
37corneal neovascularization10.3CXCL10, PLG
38membranoproliferative glomerulonephritis10.3MBL2, CD79A
39hepatitis10.3
40sinusitis10.3
41zygomycosis10.3
42trichosporonosis10.3IFNG
43interstitial lung disease10.3CD79A, SFTPD
44bronchiectasis10.3CD79A, MBL2
45neisseria meningitidis infection10.3MBL2, TLR4
46otitis media10.3MBL2, CD79A
47conjunctivitis10.3CD79A, PLG
48common variable immunodeficiency10.3CD79A, MBL2
49bronchiolitis obliterans10.3CXCL10, IL17A, CABIN1
50meningitis10.2CXCL10, MBL2, CD79A

Graphical network of the top 20 diseases related to Invasive Aspergillosis:



Diseases related to invasive aspergillosis

Symptoms for Invasive Aspergillosis

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Drugs & Therapeutics for Invasive Aspergillosis

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Drug clinical trials:

Search ClinicalTrials for Invasive Aspergillosis

Search NIH Clinical Center for Invasive Aspergillosis

Genetic Tests for Invasive Aspergillosis

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Anatomical Context for Invasive Aspergillosis

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MalaCards organs/tissues related to Invasive Aspergillosis:

32
Lung, Testes, Liver, Myeloid, Bone, Bone marrow, Kidney, Brain, Neutrophil, Whole blood, Heart, Colon, T cells, Thyroid, Breast, Skin, Endothelial

Animal Models for Invasive Aspergillosis or affiliated genes

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MGI Mouse Phenotypes related to Invasive Aspergillosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.6PLG, IL17A, CLEC7A, TLR4, IFNG
2MP:00053888.0PLG, IL17A, IFNG, CLEC7A, HBB, SFTPD
3MP:00053897.9TLR6, HBB, TPMT, TLR4, IFNG, PLG
4MP:00053677.1IFNG, TLR4, IL17A, CD79A, MBL2, CSF3
5MP:00107687.0HBB, TPMT, CLEC7A, IFNG, CXCL10, SFTPD
6MP:00053766.9SFTPD, PLG, CD79A, MBL2, IL17A, IFNG
7MP:00053875.6TLR6, TLR4, TLR1, SFTPD, CD79A, MBL2
8MP:00053975.4CSF3, TLR6, CD79A, MBL2, CABIN1, PLG

Publications for Invasive Aspergillosis

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Articles related to Invasive Aspergillosis:

(show top 50)    (show all 523)
idTitleAuthorsYear
1
PCR in diagnosis of invasive aspergillosis: a meta-analysis of diagnostic performance. (25122854)
2014
2
Serum Galactomannan-Based Early Detection of Invasive Aspergillosis in Hematology Patients Receiving Effective Antimold Prophylaxis. (25165088)
2014
3
Refractory invasive aspergillosis controlled with posaconazole and pulmonary surgery in a patient with chronic granulomatous disease: case report. (24401677)
2014
4
Comparison of a novel Aspergillus lateral-flow device and the PlateliaAr galactomannan assay for the diagnosis of invasive aspergillosis following haematopoietic stem cell transplantation. (23661288)
2013
5
TLR5 stop codon polymorphism is associated with invasive aspergillosis after allogeneic stem cell transplantation. (23862689)
2013
6
Widespread skin nodules as a manifestation of breakthrough invasive aspergillosis in a bone marrow transplant patient. (23381978)
2013
7
Characterization of specific immune responses to different Aspergillus antigens during the course of invasive Aspergillosis in hematologic patients. (24023936)
2013
8
Combined real-time PCR and galactomannan surveillance improves diagnosis of invasive aspergillosis in high risk patients with haematological malignancies. (23614624)
2013
9
Performance of serum biomarkers for the early detection of invasive aspergillosis in febrile, neutropenic patients: a multi-state model. (23799048)
2013
10
Clinical epidemiology of 960 patients with invasive aspergillosis from the PATH Alliance registry. (22898389)
2012
11
Invasive aspergillosis: an important risk factor on the short- and long-term survival of acute myeloid leukemia (AML) patients. (21909650)
2012
12
Invasive aspergillosis associated with pulmonary hydatid disease. (22824534)
2012
13
The role of combination antifungal therapy in the treatment of invasive aspergillosis: a systematic review. (22137271)
2012
14
Masaoka approach for invasive aspergillosis: an aggressive approach for an aggressive disease. (22916784)
2012
15
Invasive aspergillosis in children with acquired immunodeficiencies. (22075793)
2012
16
Epidemiology and antifungal resistance in invasive Aspergillosis according to primary disease: review of the literature. (21486729)
2011
17
Comparison of PCR-ELISA and Real-Time PCR for invasive aspergillosis diagnosis in patients with hematological malignancies. (21108574)
2011
18
Immunogenetics of invasive aspergillosis. (20840014)
2011
19
Invasive aspergillosis of orbit in immunocompetent patients: treatment and outcome. (21665281)
2011
20
Risk factors for invasive aspergillosis in acute myeloid leukemia patients prophylactically treated with posaconazole. (21314250)
2011
21
Invasive aspergillosis after pandemic (H1N1) 2009. (20507748)
2010
22
Adherence to international guidelines for the treatment of invasive aspergillosis in acute myeloid leukaemia: feasibility and utility (SEIFEM-2008B study). (20639313)
2010
23
Prophylaxis of invasive aspergillosis with voriconazole or caspofungin during building work in patients with acute leukemia. (20007135)
2010
24
Dectin-1 Y238X polymorphism associates with susceptibility to invasive aspergillosis in hematopoietic transplantation through impairment of both recipient- and donor-dependent mechanisms of antifungal immunity. (20807886)
2010
25
Risk stratification for invasive aspergillosis: early assessment of host susceptibility. (19253143)
2009
26
Aerosol and other novel administrations for prevention and treatment of invasive aspergillosis. (18654913)
2009
27
Invasive aspergillosis of the small bowel in an infant with acute myeloid leukemia and intestinal obstruction. (19206013)
2009
28
Invasive aspergillosis of the brain: radiologic-pathologic correlation. (19325053)
2009
29
Invasive aspergillosis in two liver transplant recipients: diagnosis by SeptiFast. (19210691)
2009
30
Diagnosis of invasive aspergillosis using bronchoalveolar lavage in haematology patients: influence of bronchoalveolar lavage human DNA content on real-time PCR performance. (18763000)
2009
31
Detection of circulating Aspergillus fumigatus DNA by real-time PCR assay of large serum volumes improves early diagnosis of invasive aspergillosis in high-risk adult patients under hematologic surveillance. (18845828)
2008
32
Invasive aspergillosis: diagnosis, prophylaxis and treatment. (18832929)
2008
33
Invasive aspergillosis in hematopoietic stem cell transplant recipients: a retrospective analysis. (19219277)
2008
34
Aortic thrombus during invasive aspergillosis in a kidney transplant recipient. (18296818)
2008
35
Molecular diagnosis of invasive aspergillosis in patients with hematologic malignancies - new answers to a diagnostic challenge? (23495815)
2008
36
Aspergillus galactomannan antigen in the bronchoalveolar lavage fluid for the diagnosis of invasive aspergillosis in lung transplant recipients. (17519782)
2007
37
Images in HIV/AIDS. Invasive aspergillosis presenting as a neck mass in a person with HIV/AIDS. (17672013)
2007
38
Invasive aspergillosis in the ICU: an emerging disease. (17646965)
2007
39
Invasive aspergillosis in chronic granulomatous disease: report of 7 cases. (16804696)
2007
40
Invasive aspergillosis of the brain: improvement with lyposomal amphoterecin B and itraconazole. (17921665)
2007
41
Disseminated invasive aspergillosis with cerebral involvement successfully treated with caspofungin and voriconazole. (17721739)
2007
42
Maintenance of therapeutic concentrations of caspofungin after temporary treatment interruption (48 hours) in a child with invasive aspergillosis. (17646422)
2007
43
Galactomannan antigen detection in the diagnosis of invasive aspergillosis. (17187481)
2007
44
Is combination antifungal therapy for invasive aspergillosis a necessity in hematopoietic stem-cell transplant recipients? (16804386)
2006
45
Hospital-wide prospective mandatory surveillance of invasive aspergillosis in a French teaching hospital (2000-2002). (16257084)
2006
46
Disseminated invasive aspergillosis. (17299570)
2006
47
Combination therapy with terbinafine and amphotericin B in a rabbit model of experimental invasive aspergillosis. (16251321)
2005
48
Efficacy of 2-(3,4-dimethyl-2,5-dihydro-1h-pyrrole-2-yl)-1-methylethyl pentanoate in a murine model of invasive aspergillosis. (16189123)
2005
49
Granulocyte transfusions in children with chronic granulomatous disease and invasive aspergillosis. (15828925)
2005
50
Comparison of galactomannan detection, PCR-enzyme-linked immunosorbent assay, and real-time PCR for diagnosis of invasive aspergillosis in a neutropenic rat model and effect of caspofungin acetate. (16275948)
2005

Variations for Invasive Aspergillosis

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Expression for genes affiliated with Invasive Aspergillosis

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Expression patterns in normal tissues for genes affiliated with Invasive Aspergillosis

Search GEO for disease gene expression data for Invasive Aspergillosis.

Pathways for genes affiliated with Invasive Aspergillosis

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Pathways related to Invasive Aspergillosis according to GeneCards/GeneDecks:

(show all 26)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.0TLR6, TLR1
2
Show member pathways
9.5TLR1, TLR4, TLR6
3
Show member pathways
9.5TLR4, TLR1, TLR6
49.5TLR4, TLR1, TLR6
59.3TLR1, TLR4, TLR6, CLEC7A
6
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
9.3TLR6, CLEC7A, TLR1, TLR4
7
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.3PLG, IFNG, IL17A
8
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
9.3IL17A, IFNG, CD79A
99.2TLR4, CXCL10, IFNG
10
Show member pathways
thioredoxin pathway37
9.2IFNG, HBB, PLG
119.2IFNG, IL17A, TLR4
12
Show member pathways
9.2IL17A, IFNG, TLR4
139.1CSF3, IFNG
149.1SFTPD, CLEC7A, TLR4, TLR6, MBL2
159.0TLR6, TLR4, TLR1, IFNG
16
Show member pathways
8.9PLG, IFNG, CXCL10, TLR4
17
Show member pathways
8.9TLR4, CSF3, IL17A
188.8TLR1, CLEC7A, IFNG, TLR6, TLR4
19
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.8IFNG, CXCL10, TLR1, TLR4, TLR6
20
Show member pathways
8.7IFNG, TLR1, TLR4, TLR6, IL17A
21
Show member pathways
IL27-mediated signaling events37
8.7IL17A, TLR6, TLR4, TLR1, IFNG
22
Show member pathways
8.7CD79A, IFNG, TLR1, TLR4, TLR6
23
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
8.5CXCL10, IFNG, SFTPD, TLR1, TLR6, TLR4
24
Show member pathways
8.5TLR1, TLR6, TLR4, CXCL10, CSF3
258.3CSF3, TLR4, IFNG, HBB
26
Show member pathways
8.1CSF3, IL17A, IFNG, CXCL10, TLR4

Compounds for genes affiliated with Invasive Aspergillosis

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Compounds related to Invasive Aspergillosis according to GeneCards/GeneDecks:

(show top 50)    (show all 82)
idCompoundScoreTop Affiliating Genes
1poly(i:c)6110.0TLR1, TLR4, TLR6
2pam3csk4619.9TLR1, TLR4, TLR6
3pam2csk4619.9TLR6, TLR1, TLR4
4resiquimod44 6110.9TLR6, TLR4, TLR1
5flagellin44 2810.8TLR6, TLR1, TLR4
6zymosan449.8CLEC7A, MBL2, TLR4
7lipoteichoic acid449.7MBL2, TLR1, TLR4
8peptidoglycan44 2810.7TLR4, TLR1, TLR6, MBL2
9tuberculin449.7IFNG, MBL2, CD79A
10con a449.6IFNG, MBL2, CD79A
111-methyltryptophan449.6IFNG, TLR4
12polymyxin b449.5TLR4, IFNG, MBL2
13imiquimod44 61 28 1112.4TLR6, TLR4, TLR1, IFNG
14polyinosinic-polycytidylic acid449.4TLR4, IFNG, CXCL10
15azathioprine44 2 50 1112.4CABIN1, TPMT, HBB, CD79A
162,5-oligoadenylate449.4IFNG, CXCL10, TLR4
17neopterin449.4CXCL10, IFNG, MBL2, CD79A
18poly(i-c)449.3TLR4, IFNG, CXCL10
19infliximab44 50 1111.3IL17A, IFNG, CXCL10, TLR4
20ifn-alpha449.3TLR4, CXCL10, IL17A, IFNG
21il 10449.1TLR4, CXCL10, IFNG
22creatinine449.1TPMT, CD79A, MBL2, CXCL10, IL17A
23allergens449.1TLR4, SFTPD, CXCL10, IFNG, CD79A
24ribavirin44 50 1111.0IFNG, CXCL10, MBL2, CSF3
25polysaccharide448.9SFTPD, MBL2, MBL3P, CD79A, TLR4
26pge2448.8CD79A, IL17A, IFNG, CXCL10, TLR4
27ccl344 289.8CSF3, TLR4, CXCL10, IFNG
28histamine44 28 2410.8SFTPD, TPMT, CXCL10, IFNG, CD79A, TLR4
29mannan448.7TLR4, MBL2, CD79A, MBL3P, IL17A, SFTPD
30mycophenolate mofetil44 50 1110.6CSF3, TPMT, CABIN1, CD79A, IFNG
31methotrexate50 44 1110.6TLR4, IL17A, CSF3, CD79A, TPMT
32glucose448.5TLR4, CLEC7A, CXCL10, PLG, SFTPD, MBL2
33lipid448.5TLR4, TLR6, MBL2, TLR1, PLG, SFTPD
34mannose448.5TLR4, CD79A, MBL3P, MBL2, IL17A, CLEC7A
35prednisolone44 28 1110.4SFTPD, TPMT, IFNG, CSF3, MBL2, CD79A
36tacrolimus44 50 1110.4TPMT, IFNG, CD79A, TLR4, CABIN1, IL17A
37steroid448.4PLG, SFTPD, HBB, TPMT, IL17A, CABIN1
38endotoxin448.3TLR4, SFTPD, IL17A, CXCL10, IFNG, CSF3
39anti-fungal448.3CD79A, MBL2, IFNG, SFTPD, TLR4, CSF3
40cysteine448.2IFNG, HBB, MBL2, CD79A, SFTPD, TLR4
41atp44 289.2HBB, PLG, TPMT, CXCL10, MBL2, TLR4
42rantes448.0MBL2, IL17A, CSF3, IFNG, CXCL10, TLR6
43cycloheximide448.0TLR4, CXCL10, CSF3, IFNG, HBB
44thymidine44 249.0IFNG, SFTPD, CSF3, HBB, CXCL10, IL17A
45cyclosporin a44 28 619.8TPMT, TLR4, IL17A, CSF3, CABIN1, CD79A
46nitric oxide44 24 119.8MBL2, TLR4, SFTPD, HBB, CXCL10, IL17A
47calcium44 50 24 1110.7PLB1, TLR4, SFTPD, HBB, CXCL10, MBL2
48vegf447.5CSF3, CD79A, PLG, CXCL10, IFNG, TLR4
49tyrosine447.5CLEC7A, IL17A, CSF3, TLR4, HBB, MBL2
50dexamethasone44 50 28 1110.5MBL2, IL17A, IFNG, CXCL10, TLR4, CLEC7A

GO Terms for genes affiliated with Invasive Aspergillosis

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Cellular components related to Invasive Aspergillosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.5MBL2, PLG, IFNG, CXCL10, HBB, SFTPD
2external side of plasma membraneGO:0098978.2CD79A, IL17A, IFNG, CXCL10, CLEC7A, TLR4
3extracellular spaceGO:0056157.4SFTPD, CXCL10, IFNG, IL17A, PLG, CSF3

Biological processes related to Invasive Aspergillosis according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1detection of triacyl bacterial lipopeptideGO:04249510.3TLR6, TLR1
2positive regulation of phagocytosisGO:05076610.1SFTPD, CLEC7A, MBL2
3macrophage activationGO:04211610.0TLR1, TLR4
4positive regulation of tumor necrosis factor biosynthetic processGO:04253510.0TLR4, TLR1
5T-helper 1 type immune responseGO:0420889.9TLR4, TLR6
6positive regulation of interleukin-23 productionGO:0327479.9IFNG, IL17A
7positive regulation of interleukin-6 biosynthetic processGO:0454109.8TLR6, IFNG, TLR1
8negative regulation of growth of symbiont in hostGO:0441309.8IFNG, MBL2
9positive regulation of MHC class II biosynthetic processGO:0453489.8IFNG, TLR4
10positive regulation of interleukin-12 biosynthetic processGO:0450849.8IFNG, TLR4
11defense response to protozoanGO:0428329.7CLEC7A, IFNG
12negative regulation of interleukin-17 productionGO:0327009.7IFNG, TLR4
13toll-like receptor signaling pathwayGO:0022249.7TLR6, TLR1, TLR4
14positive regulation of tumor necrosis factor productionGO:0327609.6IFNG, CLEC7A, TLR4
15inflammatory responseGO:0069549.5TLR1, IL17A, CXCL10, CLEC7A, TLR6
16positive regulation of osteoclast differentiationGO:0456729.5IFNG, IL17A
17positive regulation of interleukin-12 productionGO:0327359.5TLR4, IFNG
18positive regulation of nitric oxide biosynthetic processGO:0454299.4TLR4, HBB, IFNG
19innate immune responseGO:0450879.2MBL2, SFTPD, TLR1, TLR4, CLEC7A, TLR6
20defense response to bacteriumGO:0427429.2TLR6, TLR4, IFNG, MBL2, SFTPD
21cell surface receptor signaling pathwayGO:0071669.1CXCL10, IFNG, CABIN1
22cellular response to lipopolysaccharideGO:0712229.0CSF3, IFNG, TLR4
23immune responseGO:0069558.5IL17A, TLR4, TLR1, CXCL10, CSF3, TLR6
24positive regulation of transcription from RNA polymerase II promoterGO:0459448.3IL17A, CSF3, IFNG, CXCL10, TLR4

Molecular functions related to Invasive Aspergillosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane signaling receptor activityGO:0048888.9CD79A, TLR1, TLR4, TLR6
2cytokine activityGO:0051258.8CSF3, IL17A, IFNG

Products for genes affiliated with Invasive Aspergillosis

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Sources for Invasive Aspergillosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet