MCID: INV001
MIFTS: 49

Invasive Aspergillosis malady

Summaries for Invasive Aspergillosis

About this section
Sources:
8Disease Ontology, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Disease Ontology:8 An aspergillosis that is a serious fungal infection of the lung with pneumonia caused by aspergillus, which spreads to other parts of the body through bloodstream in patients with acute leukemia and recipients of tissue transplants. clinical symptoms include pulmonary nodules and hemorrhage.

MalaCards: Invasive Aspergillosis, also known as aspergillosis, invasive, is related to aspergillosis and acute leukemia. An important gene associated with Invasive Aspergillosis is CLEC7A (C-type lectin domain family 7, member A), and among its related pathways are Th17 Differentiation and Immune response Bacterial infections in normal airways. The compounds endotoxin and glucose have been mentioned in the context of this disorder. Affiliated tissues include lung, liver and myeloid, and related mouse phenotypes are renal/urinary system and homeostasis/metabolism.

Aliases & Classifications for Invasive Aspergillosis

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS
See all sources

Aliases & Descriptions:

invasive aspergillosis 8 10
aspergillosis, invasive 60
aspergillosis invasive 44


External Ids:

Disease Ontology8 DOID:0050073

Related Diseases for Invasive Aspergillosis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Invasive Aspergillosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 155)
idRelated DiseaseScoreTop Affiliating Genes
1aspergillosis32.0CD79A, MBL2, SFTPD, TLR4
2acute leukemia30.9CSF3, IL17A, TPMT
3leukemia30.8TLR4, MBL2, CSF3, CD79A, HBB, IL17A
4candidiasis30.6CD79A
5neutropenia30.5MBL2, CSF3, CXCL10, TPMT
6pneumonia30.5TLR4, SFTPD, MBL2, CSF3, CD79A, CXCL10
7hepatitis30.4CXCL10
8pancreatitis30.2TPMT
9lupus erythematosus30.2CD79A
10influenza30.2SFTPD, MBL3P, MBL2, CD79A, CXCL10
11cystic fibrosis30.2TLR4, SFTPD, MBL2, HBB, IL17A
12systemic lupus erythematosus30.2TLR4, MBL2, CD79A, CXCL10, IL17A, TPMT
13amyloidosis30.0CD79A
14allergic bronchopulmonary aspergillosis30.0SFTPD, MBL2
15hepatitis c30.0TLR4, CXCL10
16thyroiditis30.0MBL2, CD79A
17adenocarcinoma30.0SFTPD, CXCL10, PLG
18hematologic cancer30.0CSF3
19arthritis30.0TLR4, HBB, CXCL10, IL17A, PLG
20rheumatoid arthritis30.0TLR4, SFTPD, MBL2, CD79A, CXCL10, IL17A
21tuberculosis30.0TLR4, TLR1, SFTPD, MBL2, CD79A, HBB
22chronic granulomatous disease10.5
23acute myeloid leukemia10.4
24myeloid leukemia10.4
25non-hodgkin lymphoma10.2
26hepatitis a10.2
27lymphoblastic leukemia10.2
28ophthalmoplegia10.2
29graft versus host disease10.0
30acute thyroiditis10.0
31pearson syndrome10.0
32acute pancreatitis10.0
33antiphospholipid syndrome10.0
34multidrug-resistant tuberculosis10.0
35toxic megacolon10.0
36dengue shock syndrome10.0
37pulmonary aspergilloma10.0
38cerebritis10.0
39cushing's syndrome10.0
40carotid artery thrombosis10.0
41melas syndrome10.0
42autoimmune hemolytic anemia10.0
43autoimmune hepatitis10.0
44pyoderma gangrenosum10.0
45temporal arteritis10.0
46alcoholic hepatitis10.0
47aortic aneurysm10.0
48aplastic anemia10.0
49autosomal recessive disease10.0
50endocarditis10.0

Graphical network of the top 20 diseases related to Invasive Aspergillosis:



Diseases related to invasive aspergillosis

Clinical Features for Invasive Aspergillosis

About this section

Drugs & Therapeutics for Invasive Aspergillosis

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Invasive Aspergillosis

Drug clinical trials:

Search ClinicalTrials for Invasive Aspergillosis

Search NIH Clinical Center for Invasive Aspergillosis

Search CenterWatch for Invasive Aspergillosis

Genetic Tests for Invasive Aspergillosis

About this section

Anatomical Context for Invasive Aspergillosis

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Invasive Aspergillosis:

32
Lung, Liver, Myeloid, Testes, Bone marrow, Bone, Kidney, T cells, Heart, Colon, Brain, Whole blood, Skin, Breast, Thyroid, Endothelial

Animal Models for Invasive Aspergillosis or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Invasive Aspergillosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.4HBB, IL17A, PLG, TLR4
2MP:00053768.2TPMT, TLR4, SFTPD, MBL2, CD79A, HBB
3MP:00053977.8CD79A, TPMT, IL17A, CXCL10, CSF3, HBB
4MP:00053877.2PLG, CABIN1, TLR4, TLR6, TLR1, SFTPD

Publications for Invasive Aspergillosis

About this section
Sources:
50PubMed
See all sources

Articles related to Invasive Aspergillosis:

(show top 50)    (show all 640)
idTitleAuthorsYear
1
Comparison of a novel Aspergillus lateral-flow device and the PlateliaAr galactomannan assay for the diagnosis of invasive aspergillosis following haematopoietic stem cell transplantation. (23661288)
2013
2
Widespread skin nodules as a manifestation of breakthrough invasive aspergillosis in a bone marrow transplant patient. (23381978)
2013
3
Coinfection of Pneumocystis jirovecii and invasive pulmonary aspergillosis in an immunocompromised patient: a diagnostic challenge. (24107913)
2013
4
Isavuconazole (BAL4815) pharmacodynamic target determination in an in vivo murine model of invasive pulmonary aspergillosis against wild-type and cyp51 mutant isolates of Aspergillus fumigatus. (24100500)
2013
5
Hypothermic endpoint for an intranasal invasive pulmonary aspergillosis mouse model. (24326222)
2013
6
Aspergillus PCR-based investigation of fresh tissue and effusion samples in patients with suspected invasive Aspergillosis enhances diagnostic capabilities. (24108612)
2013
7
New insights into invasive aspergillosis--from the pathogen to the disease. (23278533)
2013
8
Galactomannan and PCR versus culture and histology for directing use of antifungal treatment for invasive aspergillosis in high-risk haematology patients: a randomised controlled trial. (23639612)
2013
9
Aerosolized liposomal amphotericin B: A potential prophylaxis of invasive pulmonary aspergillosis in immunocompromised patients. (23843366)
2013
10
Establishment and application of real-time quantitative PCR for diagnosing invasive aspergillosis via the blood in hematological patients: targeting a specific sequence of Aspergillus 28S-ITS2. (23725402)
2013
11
Pharmacoeconomic assessment of therapy for invasive aspergillosis. (23311989)
2013
12
Impact of in vivo triazole and echinocandin combination therapy for invasive pulmonary aspergillosis: enhanced efficacy against Cyp51 mutant isolates. (23959322)
2013
13
Electronic nose technology for detection of invasive pulmonary aspergillosis in prolonged chemotherapy-induced neutropenia: a proof-of-principle study. (23467602)
2013
14
Combination of voriconazole and anidulafungin for treatment of triazole-resistant aspergillus fumigatus in an in vitro model of invasive pulmonary aspergillosis. (22825124)
2012
15
A nebulized intra-tracheal rat model of invasive pulmonary aspergillosis. (22328399)
2012
16
Importance of elastase production in development of invasive aspergillosis. (23518019)
2012
17
Invasive aspergillosis in a renal transplant recipient successfully treated with interferon-gamma. (23259133)
2012
18
Diagnostic and therapeutic challenges in a liver transplant recipient with central nervous system invasive aspergillosis. (22676861)
2012
19
Influenza A (H1N1) complicated by invasive aspergillosis in non-severely immunocompromised patients. (22521960)
2012
20
Comparison of PCR-ELISA and Real-Time PCR for invasive aspergillosis diagnosis in patients with hematological malignancies. (21108574)
2011
21
Risk factors for invasive aspergillosis in acute myeloid leukemia patients prophylactically treated with posaconazole. (21314250)
2011
22
Usefulness of serial determination of Aspergillus galactomannan in the diagnosis and management of invasive aspergillosis in an AIDS patient with non-Hodgkin lymphoma. (21672046)
2011
23
Twenty-nine cases of invasive aspergillosis in neutropenic patients. (22036518)
2011
24
Hospital costs and outcomes among intravenous antifungal therapies for patients with invasive aspergillosis in the United States. (20557463)
2011
25
Invasive aspergillosis after pandemic (H1N1) 2009. (20507748)
2010
26
Impact of prior invasive aspergillosis on outcome in patients receiving reduced-intensity conditioning allogeneic hematopoietic stem cell transplant. (20629522)
2010
27
TNFR1 mRNA expression level and TNFR1 gene polymorphisms are predictive markers for susceptibility to develop invasive pulmonary aspergillosis. (20646338)
2010
28
The economic impact of invasive aspergillosis in intensive care unit patients. (19713140)
2010
29
Computer tomography in pulmonary invasive aspergillosis in hematological patients with neutropenia: an useful tool for diagnosis and assessment of outcome in clinical trials. (19577873)
2010
30
Risk factors for invasive aspergillosis and related mortality in recipients of allogeneic SCT from alternative donors: an analysis of 306 patients. (19308042)
2009
31
Economic evaluation of voriconazole versus caspofungin for the treatment of invasive aspergillosis in Belgium. (19999386)
2009
32
Impaired interferon-gamma responses, increased interleukin-17 expression, and a tumor necrosis factor-alpha transcriptional program in invasive aspergillosis. (19754306)
2009
33
Treosulfan-based conditioning regimen in a second matched unrelated peripheral blood stem cell transplantation for a pediatric patient with CGD and invasive aspergillosis, who experienced initial graft failure after RIC. (19866337)
2009
34
IL1 gene cluster polymorphisms and its haplotypes may predict the risk to develop invasive pulmonary aspergillosis and modulate C-reactive protein level. (18484169)
2008
35
Primary gastrointestinal aspergillosis after autologous peripheral blood progenitor cell transplantation: an unusual presentation of invasive aspergillosis. (18069930)
2008
36
Therapeutic drug monitoring of voriconazole in a child with invasive aspergillosis requiring extracorporeal membrane oxygenation. (19057370)
2008
37
Methylcitrate synthase from Aspergillus fumigatus is essential for manifestation of invasive aspergillosis. (17973657)
2008
38
Assessment of the lightcycler PCR assay for diagnosis of invasive aspergillosis in paediatric patients with onco-haematological diseases. (18331444)
2008
39
Molecular detection of invasive aspergillosis in hematologic malignancies. (18854937)
2008
40
Galactomannan antigen detection in the diagnosis of invasive aspergillosis. (17187481)
2007
41
Role of Toll-like receptors in lung innate defense against invasive aspergillosis. Distinct impact in immunocompetent and immunocompromized hosts. (17604224)
2007
42
Invasive aspergillosis following hematopoietic cell transplantation: outcomes and prognostic factors associated with mortality. (17243056)
2007
43
Interleukin-10 promoter polymorphism as risk factor to develop invasive pulmonary aspergillosis. (17321603)
2007
44
Increased bone marrow iron stores is an independent risk factor for invasive aspergillosis in patients with high-risk hematologic malignancies and recipients of allogeneic hematopoietic stem cell transplantation. (17614303)
2007
45
Breakthrough invasive aspergillosis in allogeneic haematopoietic stem cell transplant recipients treated with caspofungin. (18029149)
2007
46
Invasive aspergillosis and thrombosis of carotid artery. (16599286)
2006
47
Use of galactomannan enzyme immunoassay for diagnosis of invasive aspergillosis in a tertiary-care center over a 12-month period. (16597909)
2006
48
Granulocyte transfusions in children with chronic granulomatous disease and invasive aspergillosis. (15828925)
2005
49
Invasive aspergillosis in two patients with Pearson syndrome. (10462353)
1999
50
Virulence of Aspergillus fumigatus double mutants lacking restriction and an alkaline protease in a low-dose model of invasive pulmonary aspergillosis. (7960101)
1994

Genetic Variations for Invasive Aspergillosis

About this section

Expression for genes affiliated with Invasive Aspergillosis

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Invasive Aspergillosis

Search GEO for disease gene expression data for Invasive Aspergillosis.

Pathways for genes affiliated with Invasive Aspergillosis

About this section
Sources:
52R&D Systems, 53Reactome, 51QIAGEN, 59Tocris Bioscience, 4Cell Signaling Technology, 29KEGG, 12EMD Millipore, 37NCBI BioSystems Database
See all sources

Pathways related to Invasive Aspergillosis according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.1TLR6, TLR1
2
Immune response Bacterial infections in normal airways
9.8SFTPD, TLR1, TLR4
3
Hide members
9.8TLR1, TLR6, TLR4
49.8TLR4, TLR6, TLR1
59.8TLR4, TLR6, TLR1
69.6CLEC7A, TLR1, TLR6, TLR4
79.6TLR4, TLR6, TLR1, CLEC7A
8
Hide members
9.6TLR4, TLR6, TLR1, CLEC7A
99.6CXCL10, TLR1, TLR6, TLR4
10
Hide members
9.6CXCL10, TLR1, TLR6, TLR4
11
Hide members
9.6TLR4, TLR6, TLR1, IL17A
12
Hide members
9.5CD79A, TLR1, TLR6, TLR4
13
Cytokine production by Th17 cells in CF (Mouse model)
9.4IL17A, CSF3, TLR4
149.4CLEC7A, MBL2, SFTPD, TLR6, TLR4
159.4HBB, CSF3, TLR4
16
Hide members
9.1TLR4, TLR6, TLR1, CSF3, CXCL10

Compounds for genes affiliated with Invasive Aspergillosis

About this section
Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB, 2BitterDB, 24HMDB
See all sources

Compounds related to Invasive Aspergillosis according to GeneCards/GeneDecks:

(show all 48)
idCompoundScoreTop Affiliating Genes
1endotoxin4410.4CSF3
2glucose4410.3CLEC7A, SFTPD
3pam2csk45910.2TLR4, TLR6, TLR1
4pam3csk45910.2TLR4, TLR6, TLR1
5poly(i:c)5910.2TLR4, TLR6, TLR1
6resiquimod44 5911.2TLR4, TLR6, TLR1
7zymosan4410.2TLR4, MBL2, CLEC7A
8flagellin44 2811.2TLR1, TLR6, TLR4
9imiquimod44 28 59 1113.2TLR1, TLR6, TLR4
10lipoteichoic acid4410.1TLR4, TLR1, MBL2
11infliximab44 49 1112.0IL17A, CXCL10, TLR4
12prednisolone44 28 1112.0SFTPD, MBL2, CD79A, TPMT
13peptidoglycan44 2811.0MBL2, TLR1, TLR6, TLR4
14neopterin4410.0CXCL10, CD79A, MBL2
15ifn-alpha4410.0IL17A, CXCL10, TLR4
16tuberculin4410.0CD79A, MBL2
17n-acetylglucosamine4410.0MBL2, MBL3P, SFTPD
18dexamethasone44 49 28 1113.0TLR4, SFTPD, CD79A, CLEC7A
19pneumococcal4410.0CD79A, TLR4
20allergens449.9TLR4, SFTPD, CD79A, CXCL10
21chloroquine44 2 49 28 1113.8TLR4, CD79A, CXCL10
22ribavirin44 49 1111.8MBL2, CSF3, CXCL10
23azathioprine44 49 2 1112.8CABIN1, CD79A, HBB, TPMT
24ccl344 2810.7TLR4, CSF3, CXCL10
25rantes449.7TLR4, MBL2, CSF3, IL17A
26histamine44 28 2411.6TLR4, SFTPD, CD79A, CXCL10, TPMT
27suramin44 28 1111.6PLG, CXCL10, CD79A
28mycophenolate mofetil44 49 1111.6TPMT, CD79A, CSF3, CABIN1
29vitamin d449.6TLR4, MBL2, CD79A, CXCL10
30estrogen449.6MBL2, SSBP3, CD79A
31creatinine449.6MBL2, CD79A, CXCL10, IL17A, TPMT
32polysaccharide449.5TLR4, SFTPD, MBL3P, MBL2, CD79A
33methotrexate44 49 1111.5TPMT, IL17A, CD79A, CSF3
34fibrinogen449.5TLR4, MBL2, CD79A, PLG
35anti-fungal449.4TLR4, SFTPD, MBL2, CSF3, CD79A
36tacrolimus44 49 1111.4CABIN1, TLR4, CD79A, CXCL10, IL17A, TPMT
37mannan449.4IL17A, CD79A, MBL2, MBL3P, SFTPD, TLR4
38mannose449.2TLR4, SFTPD, MBL3P, MBL2, CD79A, CLEC7A
39thymidine44 2410.2SFTPD, CSF3, HBB, CXCL10, IL17A, PLG
40lipid449.1TLR4, TLR6, TLR1, SFTPD, MBL2, CXCL10
41cyclosporin a44 28 5911.1CABIN1, TLR4, CSF3, CD79A, IL17A, TPMT
42steroid449.0CABIN1, SFTPD, MBL2, CD79A, HBB, IL17A
43nitric oxide44 11 2411.0CABIN1, TLR4, SFTPD, MBL2, HBB, CXCL10
44vegf448.9TLR4, MBL2, CSF3, CD79A, CXCL10, IL17A
45atp44 289.8TLR4, MBL2, SSBP3, HBB, CXCL10, PLG
46cysteine448.7TLR4, SFTPD, MBL2, SSBP3, CD79A, HBB
47tyrosine448.5TLR4, MBL2, CSF3, HBB, CLEC7A, CXCL10
48serine448.5TLR4, MBL3P, SSBP3, HBB, PLG

GO Terms for genes affiliated with Invasive Aspergillosis

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Invasive Aspergillosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.0IL17A, CXCL10, CLEC7A, CD79A, TLR4
2extracellular spaceGO:0056158.9MBL2, CSF3, CXCL10, IL17A, PLG, SFTPD

Biological processes related to Invasive Aspergillosis according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1toll-like receptor 6 signaling pathwayGO:03415010.3TLR1, TLR6
2detection of diacyl bacterial lipopeptideGO:04249610.2TLR1, TLR6
3positive regulation of interleukin-6 biosynthetic processGO:04541010.2TLR6, TLR1
4positive regulation of phagocytosisGO:05076610.1CLEC7A, MBL2, SFTPD
5regulation of cytokine secretionGO:05070710.1TLR1, TLR6, TLR4
6T-helper 1 type immune responseGO:04208810.0TLR4, TLR6, TLR1
7macrophage activationGO:04211610.0TLR1, TLR4
8defense response to bacteriumGO:0427429.8MBL2, TLR6, TLR4
9positive regulation of tumor necrosis factor biosynthetic processGO:0425359.7TLR1, TLR4
10MyD88-dependent toll-like receptor signaling pathwayGO:0027559.7TLR4, TLR6, TLR1
11inflammatory responseGO:0069549.6TLR6, TLR1, CLEC7A, CXCL10, IL17A
12innate immune responseGO:0450879.4TLR4, TLR6, TLR1, SFTPD, MBL2, CLEC7A
13immune responseGO:0069559.1TLR4, TLR6, TLR1, CSF3, CXCL10, IL17A

Molecular functions related to Invasive Aspergillosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane signaling receptor activityGO:0048889.5CD79A, TLR1, TLR6, TLR4

Products for genes affiliated with Invasive Aspergillosis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Invasive Aspergillosis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet