MCID: INV001
MIFTS: 49

Invasive Aspergillosis malady

Summaries for Invasive Aspergillosis

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 An aspergillosis that is a serious fungal infection of the lung with pneumonia caused by aspergillus, which spreads to other parts of the body through bloodstream in patients with acute leukemia and recipients of tissue transplants. clinical symptoms include pulmonary nodules and hemorrhage.

MalaCards: Invasive Aspergillosis, also known as aspergillosis, invasive, is related to aspergillosis and acute leukemia. An important gene associated with Invasive Aspergillosis is CLEC7A (C-type lectin domain family 7, member A), and among its related pathways are Th17 Differentiation and Immune response Bacterial infections in normal airways. The compounds endotoxin and glucose have been mentioned in the context of this disorder. Affiliated tissues include lung, liver and myeloid, and related mouse phenotypes are renal/urinary system and homeostasis/metabolism.

Aliases & Classifications for Invasive Aspergillosis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS
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Aliases & Descriptions:

invasive aspergillosis 8 10
aspergillosis, invasive 60
aspergillosis invasive 44


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Disease Ontology8 DOID:0050073

Related Diseases for Invasive Aspergillosis

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17GeneCards, 18GeneDecks
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Diseases related to Invasive Aspergillosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 155)
idRelated DiseaseScoreTop Affiliating Genes
1aspergillosis32.0CD79A, MBL2, SFTPD, TLR4
2acute leukemia30.9CSF3, IL17A, TPMT
3leukemia30.8TLR4, MBL2, CSF3, CD79A, HBB, IL17A
4candidiasis30.6CD79A
5neutropenia30.5MBL2, CSF3, CXCL10, TPMT
6pneumonia30.5TLR4, SFTPD, MBL2, CSF3, CD79A, CXCL10
7hepatitis30.4CXCL10
8pancreatitis30.2TPMT
9lupus erythematosus30.2CD79A
10influenza30.2SFTPD, MBL3P, MBL2, CD79A, CXCL10
11cystic fibrosis30.2TLR4, SFTPD, MBL2, HBB, IL17A
12systemic lupus erythematosus30.2TLR4, MBL2, CD79A, CXCL10, IL17A, TPMT
13amyloidosis30.0CD79A
14allergic bronchopulmonary aspergillosis30.0SFTPD, MBL2
15hepatitis c30.0TLR4, CXCL10
16thyroiditis30.0MBL2, CD79A
17adenocarcinoma30.0SFTPD, CXCL10, PLG
18hematologic cancer30.0CSF3
19arthritis30.0TLR4, HBB, CXCL10, IL17A, PLG
20rheumatoid arthritis30.0TLR4, SFTPD, MBL2, CD79A, CXCL10, IL17A
21tuberculosis30.0TLR4, TLR1, SFTPD, MBL2, CD79A, HBB
22chronic granulomatous disease10.5
23acute myeloid leukemia10.4
24myeloid leukemia10.4
25non-hodgkin lymphoma10.2
26hepatitis a10.2
27lymphoblastic leukemia10.2
28ophthalmoplegia10.2
29graft versus host disease10.0
30acute thyroiditis10.0
31pearson syndrome10.0
32acute pancreatitis10.0
33antiphospholipid syndrome10.0
34multidrug-resistant tuberculosis10.0
35toxic megacolon10.0
36dengue shock syndrome10.0
37pulmonary aspergilloma10.0
38cerebritis10.0
39cushing's syndrome10.0
40carotid artery thrombosis10.0
41melas syndrome10.0
42autoimmune hemolytic anemia10.0
43autoimmune hepatitis10.0
44pyoderma gangrenosum10.0
45temporal arteritis10.0
46alcoholic hepatitis10.0
47aortic aneurysm10.0
48aplastic anemia10.0
49autosomal recessive disease10.0
50endocarditis10.0

Graphical network of the top 20 diseases related to Invasive Aspergillosis:



Diseases related to invasive aspergillosis

Clinical Features for Invasive Aspergillosis

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Drugs & Therapeutics for Invasive Aspergillosis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Invasive Aspergillosis

Drug clinical trials:

Search ClinicalTrials for Invasive Aspergillosis

Search NIH Clinical Center for Invasive Aspergillosis

Search CenterWatch for Invasive Aspergillosis

Genetic Tests for Invasive Aspergillosis

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Anatomical Context for Invasive Aspergillosis

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32MalaCards
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MalaCards organs/tissues related to Invasive Aspergillosis:

32
Lung, Liver, Myeloid, Testes, Bone marrow, Bone, Kidney, T cells, Heart, Colon, Brain, Whole blood, Skin, Breast, Thyroid, Endothelial

Animal Models for Invasive Aspergillosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Invasive Aspergillosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.4TLR4, HBB, IL17A, PLG
2MP:00053768.2SFTPD, MBL2, CD79A, HBB, CLEC7A, CXCL10
3MP:00053977.8TLR4, SFTPD, MBL2, CSF3, CD79A, HBB
4MP:00053877.2PLG, CABIN1, TLR4, TLR6, TLR1, SFTPD

Publications for Invasive Aspergillosis

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50PubMed
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Articles related to Invasive Aspergillosis:

(show top 50)    (show all 640)
idTitleAuthorsYear
1
Performance of serum biomarkers for the early detection of invasive aspergillosis in febrile, neutropenic patients: a multi-state model. (23799048)
2013
2
Therapeutic drug monitoring of voriconazole and posaconazole for invasive aspergillosis. (24053274)
2013
3
Successful treatment of acute thyroiditis due to Aspergillus spp. in the context of disseminated invasive aspergillosis in a kidney transplant patient. (23897207)
2013
4
Efficacy of liposomal amphotericin B for prophylaxis of acute or reactivation models of invasive pulmonary aspergillosis. (22998025)
2013
5
Concomitant occurrence of pulmonary invasive aspergillosis and Pneumocystis pneumonia during FOLFIRINOX chemotherapy for pancreatic carcinoma. (23254917)
2013
6
Serum galactomannan assay for diagnosis of probable invasive Aspergillosis in acute leukemia and hematopoietic stem cell transplantation. (24049291)
2013
7
Invasive pulmonary aspergillosis in patients with chronic obstructive pulmonary disease. (24135224)
2013
8
Invasive aspergillosis associated with pulmonary hydatid disease. (22824534)
2012
9
Persistent poor long-term prognosis of allogeneic hematopoietic stem cell transplant recipients surviving invasive aspergillosis. (22371177)
2012
10
Real-time nucleic acid sequence-based amplification to predict the clinical outcome of invasive aspergillosis. (22219607)
2012
11
Remarkably efficient inhaled antifungal monotherapy for invasive pulmonary aspergillosis. (22753838)
2012
12
Immunoproteomics based identification of thioredoxin reductase GliT and novel Aspergillus fumigatus antigens for serologic diagnosis of invasive aspergillosis. (22251604)
2012
13
The strategy for the diagnosis of invasive pulmonary aspergillosis should depend on both the underlying condition and the leukocyte count of patients with hematologic malignancies. (22010103)
2012
14
Prolonged use of extracorporeal membrane oxygenation combined with prone positioning in patients with acute respiratory distress syndrome and invasive Aspergillosis. (22438221)
2012
15
Detection of urinary excreted fungal galactomannan-like antigens for diagnosis of invasive aspergillosis. (22900046)
2012
16
Drosophila melanogaster as a model organism for invasive aspergillosis. (22328395)
2012
17
Initial computed tomography findings of invasive pulmonary aspergillosis in non-hematological patients. (22932167)
2012
18
Combined lateral orbitotomy and endoscopic transnasal orbital decompression in a case of orbital aspergillosis with impending intracranial invasion. (23341818)
2012
19
Immunogenetics of invasive aspergillosis. (20840014)
2011
20
Spontaneous Pneumothorax in an Allogeneic Cell Transplant Recipient with Invasive Pulmonary Aspergillosis and Antecedent RSV Pneumonitis. (21625303)
2011
21
Pulmonary carcinosarcoma initially presenting as invasive aspergillosis: a case report of previously unreported combination. (20181054)
2010
22
Invasive aspergillosis of the brain: radiologic-pathologic correlation. (19325053)
2009
23
Successful voriconazole treatment of invasive pulmonary aspergillosis in a patient with acute biphenotypic leukemia. (19727206)
2009
24
Invasive aspergillosis due to Neosartorya udagawae. (19489714)
2009
25
Micafungin alone or in combination with other systemic antifungal therapies in hematopoietic stem cell transplant recipients with invasive aspergillosis. (18983417)
2009
26
Susceptibility of mice to invasive aspergillosis correlates with delayed cell influx into the lungs. (19744035)
2009
27
Detection of circulating Aspergillus fumigatus DNA by real-time PCR assay of large serum volumes improves early diagnosis of invasive aspergillosis in high-risk adult patients under hematologic surveillance. (18845828)
2008
28
Fatal outcome of disseminated invasive aspergillosis in kidney allograft recipients. (18686167)
2008
29
Invasive aspergillosis and allogeneic hematopoietic stem cell transplantation in children: a 15-year experience. (18331389)
2008
30
Factors associated with overall and attributable mortality in invasive aspergillosis. (18808352)
2008
31
Microsatellite typing of Aspergillus fumigatus isolates recovered from deep organ samples of patients with invasive aspergillosis. (18501550)
2008
32
Invasive aspergillosis in severely immunosuppressed patients: significant progress, but many unresolved problems. (18489674)
2008
33
Combination therapeutic approaches for the management of invasive aspergillosis in organ transplant recipients. (18254745)
2008
34
Using the galactomannan assay in the diagnosis of invasive aspergillosis. (18623894)
2008
35
Invasive aspergillosis in the ICU: an emerging disease. (17646965)
2007
36
Caspofungin as salvage monotherapy for invasive aspergillosis in patients with haematological malignancies or following allogeneic stem cell transplantation: efficacy and concomitant cyclosporin A. (17394607)
2007
37
Economic evaluation of voriconazole versus caspofungin for the treatment of invasive aspergillosis in Spain. (17305414)
2007
38
Diagnosis of invasive aspergillosis by tracking Aspergillus-specific T cells in hematologic patients with pulmonary infiltrates. (17215858)
2007
39
The role of CC chemokine receptor 6 in host defense in a model of invasive pulmonary aspergillosis. (17379855)
2007
40
The debate: a case for randomized controls in invasive aspergillosis. (17050456)
2006
41
Life-threatening toxic epidermal necrolysis during voriconazole therapy for invasive aspergillosis after chemotherapy. (16410362)
2006
42
Prognostic factors for death due to invasive aspergillosis after hematopoietic stem cell transplantation: a 1-year retrospective study of consecutive patients at French transplantation centers. (16511759)
2006
43
Invasive aspergillosis in association with criminal arsenic poisoning. (16356753)
2006
44
Prospective evaluation of a polymerase chain reaction-ELISA targeted to Aspergillus fumigatus and Aspergillus flavus for the early diagnosis of invasive aspergillosis in patients with hematological malignancies. (16453271)
2006
45
Epidemiology, outcomes, and costs of invasive aspergillosis in immunocompromised children in the United States, 2000. (16533892)
2006
46
Strategy of following voriconazole versus amphotericin B therapy with other licensed antifungal therapy for primary treatment of invasive aspergillosis: impact of other therapies on outcome. (16231256)
2005
47
Invasive aspergillosis in an immunocompetent host. (17278668)
2005
48
Simultaneous legionellosis and invasive aspergillosis in an immunocompetent patient newly treated with corticosteroids. (8252995)
1993
49
Prolonged granulocytopenia: the major risk factor for invasive pulmonary aspergillosis in patients with acute leukemia. (6696356)
1984
50
Invasive aspergillosis complicating resection of a pulmonary aspergilloma in a nonimmunocompromised host. (7181232)
1982

Genetic Variations for Invasive Aspergillosis

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Expression for genes affiliated with Invasive Aspergillosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Invasive Aspergillosis

Search GEO for disease gene expression data for Invasive Aspergillosis.

Pathways for genes affiliated with Invasive Aspergillosis

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52R&D Systems, 53Reactome, 51QIAGEN, 59Tocris Bioscience, 4Cell Signaling Technology, 29KEGG, 12EMD Millipore, 37NCBI BioSystems Database
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Pathways related to Invasive Aspergillosis according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.1TLR6, TLR1
2
Immune response Bacterial infections in normal airways
9.8SFTPD, TLR1, TLR4
3
Hide members
9.8TLR1, TLR6, TLR4
49.8TLR4, TLR6, TLR1
59.8TLR4, TLR6, TLR1
69.6CLEC7A, TLR1, TLR6, TLR4
79.6TLR4, TLR6, TLR1, CLEC7A
8
Hide members
9.6TLR4, TLR6, TLR1, CLEC7A
99.6CXCL10, TLR1, TLR6, TLR4
10
Hide members
9.6CXCL10, TLR1, TLR6, TLR4
11
Hide members
9.6TLR4, TLR6, TLR1, IL17A
12
Hide members
9.5CD79A, TLR1, TLR6, TLR4
13
Cytokine production by Th17 cells in CF (Mouse model)
9.4IL17A, CSF3, TLR4
149.4CLEC7A, MBL2, SFTPD, TLR6, TLR4
159.4HBB, CSF3, TLR4
16
Hide members
9.1TLR4, TLR6, TLR1, CSF3, CXCL10

Compounds for genes affiliated with Invasive Aspergillosis

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB, 2BitterDB, 24HMDB
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Compounds related to Invasive Aspergillosis according to GeneCards/GeneDecks:

(show all 48)
idCompoundScoreTop Affiliating Genes
1endotoxin4410.4CSF3
2glucose4410.3CLEC7A, SFTPD
3pam2csk45910.2TLR4, TLR6, TLR1
4pam3csk45910.2TLR4, TLR6, TLR1
5poly(i:c)5910.2TLR4, TLR6, TLR1
6resiquimod44 5911.2TLR4, TLR6, TLR1
7zymosan4410.2TLR4, MBL2, CLEC7A
8flagellin44 2811.2TLR1, TLR6, TLR4
9imiquimod44 28 59 1113.2TLR1, TLR6, TLR4
10lipoteichoic acid4410.1TLR4, TLR1, MBL2
11infliximab44 49 1112.0IL17A, CXCL10, TLR4
12prednisolone44 28 1112.0SFTPD, MBL2, CD79A, TPMT
13peptidoglycan44 2811.0MBL2, TLR1, TLR6, TLR4
14neopterin4410.0CXCL10, CD79A, MBL2
15ifn-alpha4410.0IL17A, CXCL10, TLR4
16tuberculin4410.0CD79A, MBL2
17n-acetylglucosamine4410.0MBL2, MBL3P, SFTPD
18dexamethasone44 49 28 1113.0TLR4, SFTPD, CD79A, CLEC7A
19pneumococcal4410.0CD79A, TLR4
20allergens449.9TLR4, SFTPD, CD79A, CXCL10
21chloroquine44 2 49 28 1113.8TLR4, CD79A, CXCL10
22ribavirin44 49 1111.8MBL2, CSF3, CXCL10
23azathioprine44 49 2 1112.8CABIN1, CD79A, HBB, TPMT
24ccl344 2810.7TLR4, CSF3, CXCL10
25rantes449.7TLR4, MBL2, CSF3, IL17A
26histamine44 28 2411.6TLR4, SFTPD, CD79A, CXCL10, TPMT
27suramin44 28 1111.6PLG, CXCL10, CD79A
28mycophenolate mofetil44 49 1111.6TPMT, CD79A, CSF3, CABIN1
29vitamin d449.6TLR4, MBL2, CD79A, CXCL10
30estrogen449.6MBL2, SSBP3, CD79A
31creatinine449.6MBL2, CD79A, CXCL10, IL17A, TPMT
32polysaccharide449.5TLR4, SFTPD, MBL3P, MBL2, CD79A
33methotrexate44 49 1111.5TPMT, IL17A, CD79A, CSF3
34fibrinogen449.5TLR4, MBL2, CD79A, PLG
35anti-fungal449.4TLR4, SFTPD, MBL2, CSF3, CD79A
36tacrolimus44 49 1111.4CABIN1, TLR4, CD79A, CXCL10, IL17A, TPMT
37mannan449.4IL17A, CD79A, MBL2, MBL3P, SFTPD, TLR4
38mannose449.2TLR4, SFTPD, MBL3P, MBL2, CD79A, CLEC7A
39thymidine44 2410.2SFTPD, CSF3, HBB, CXCL10, IL17A, PLG
40lipid449.1TLR4, TLR6, TLR1, SFTPD, MBL2, CXCL10
41cyclosporin a44 28 5911.1CABIN1, TLR4, CSF3, CD79A, IL17A, TPMT
42steroid449.0CABIN1, SFTPD, MBL2, CD79A, HBB, IL17A
43nitric oxide44 11 2411.0CABIN1, TLR4, SFTPD, MBL2, HBB, CXCL10
44vegf448.9TLR4, MBL2, CSF3, CD79A, CXCL10, IL17A
45atp44 289.8TLR4, MBL2, SSBP3, HBB, CXCL10, PLG
46cysteine448.7TLR4, SFTPD, MBL2, SSBP3, CD79A, HBB
47tyrosine448.5TLR4, MBL2, CSF3, HBB, CLEC7A, CXCL10
48serine448.5TLR4, MBL3P, SSBP3, HBB, PLG

GO Terms for genes affiliated with Invasive Aspergillosis

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16Gene Ontology
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Cellular components related to Invasive Aspergillosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.0IL17A, CXCL10, CLEC7A, CD79A, TLR4
2extracellular spaceGO:0056158.9MBL2, CSF3, CXCL10, IL17A, PLG, SFTPD

Biological processes related to Invasive Aspergillosis according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1toll-like receptor 6 signaling pathwayGO:03415010.3TLR1, TLR6
2detection of diacyl bacterial lipopeptideGO:04249610.2TLR1, TLR6
3positive regulation of interleukin-6 biosynthetic processGO:04541010.2TLR6, TLR1
4positive regulation of phagocytosisGO:05076610.1CLEC7A, MBL2, SFTPD
5regulation of cytokine secretionGO:05070710.1TLR1, TLR6, TLR4
6T-helper 1 type immune responseGO:04208810.0TLR4, TLR6, TLR1
7macrophage activationGO:04211610.0TLR1, TLR4
8defense response to bacteriumGO:0427429.8MBL2, TLR6, TLR4
9positive regulation of tumor necrosis factor biosynthetic processGO:0425359.7TLR1, TLR4
10MyD88-dependent toll-like receptor signaling pathwayGO:0027559.7TLR4, TLR6, TLR1
11inflammatory responseGO:0069549.6TLR6, TLR1, CLEC7A, CXCL10, IL17A
12innate immune responseGO:0450879.4TLR4, TLR6, TLR1, SFTPD, MBL2, CLEC7A
13immune responseGO:0069559.1TLR4, TLR6, TLR1, CSF3, CXCL10, IL17A

Molecular functions related to Invasive Aspergillosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane signaling receptor activityGO:0048889.5CD79A, TLR1, TLR6, TLR4

Products for genes affiliated with Invasive Aspergillosis

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Sources for Invasive Aspergillosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet