MCID: INV001
MIFTS: 51

Invasive Aspergillosis malady

Summaries for Invasive Aspergillosis

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Disease Ontology:10 An aspergillosis that is a serious fungal infection of the lung with pneumonia caused by aspergillus, which spreads to other parts of the body through bloodstream in patients with acute leukemia and recipients of tissue transplants. clinical symptoms include pulmonary nodules and hemorrhage.

MalaCards based summary: Invasive Aspergillosis, also known as aspergillosis, invasive, is related to aspergillosis and leukemia. An important gene associated with Invasive Aspergillosis is CLEC7A (C-type lectin domain family 7, member A), and among its related pathways are TRAF Pathway and TNF Signaling. The compounds poly(i:c) and pam3csk4 have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and liver, and related mouse phenotypes are digestive/alimentary and respiratory system.

Aliases & Classifications for Invasive Aspergillosis

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Sources:
10Disease Ontology, 12DISEASES, 45Novoseek, 62UMLS
See all sources

Invasive Aspergillosis, Aliases & Descriptions:

Name: Invasive Aspergillosis 10 12
Aspergillosis, Invasive 62
 
Aspergillosis Invasive 45


External Ids:

Disease Ontology10 DOID:0050073

Related Diseases for Invasive Aspergillosis

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Diseases related to Invasive Aspergillosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 134)
idRelated DiseaseScoreTop Affiliating Genes
1aspergillosis32.1CD79A, MBL2, IFNG, SFTPD, TLR4
2leukemia30.8TLR4, HBB, TPMT, IFNG, IL17A, PLG
3candidiasis30.8CD79A, PLB1, IFNG
4neutropenia30.7TPMT, CXCL10, CSF3, MBL2
5acute leukemia30.5CSF3, IL17A, TPMT
6pneumonia30.5TLR4, SFTPD, CXCL10, IL17A, CSF3, MBL2
7cystic fibrosis30.3TLR4, SFTPD, HBB, IL17A, MBL2
8colitis30.3IL17A, IFNG, CXCL10, TLR4
9influenza30.3SFTPD, CXCL10, IFNG, MBL2, MBL3P, CD79A
10systemic lupus erythematosus30.2TLR4, TPMT, CXCL10, IFNG, IL17A, MBL2
11thyroiditis30.2MBL2, CD79A
12liver disease30.1TLR4, CABIN1, CD79A
13acute respiratory distress syndrome30.1PLG, SFTPD
14acute graft versus host disease30.1IFNG, CSF3
15hepatitis c30.1TLR4, CXCL10, IFNG
16ulcerative colitis30.0TLR4, TPMT, CXCL10, IFNG, IL17A, CD79A
17arthritis30.0TLR4, HBB, CXCL10, IFNG, IL17A, PLG
18rheumatoid arthritis29.9TLR4, SFTPD, TPMT, CXCL10, IFNG, IL17A
19tuberculosis29.9TLR4, TLR1, SFTPD, HBB, CLEC7A, CXCL10
20hematopoietic stem cell transplantation10.8
21chronic granulomatous disease10.6
22myeloid leukemia10.5
23hepatitis10.3
24sinusitis10.3
25zygomycosis10.3
26hodgkin lymphoma10.2
27lupus erythematosus10.2
28lymphoblastic leukemia10.2
29ophthalmoplegia10.2
30pancreatitis10.2
31myelodysplastic syndrome10.1
32aplastic anemia10.1
33alcoholic hepatitis10.1
34hematologic cancer10.1
35hemolytic anemia10.1
36pearson syndrome10.1
37toxic megacolon10.1
38multidrug-resistant tuberculosis10.1
39antiphospholipid syndrome10.1
40clostridium difficile colitis10.1
41autoimmune hemolytic anemia10.1
42pyoderma gangrenosum10.1
43toxocariasis10.1
44dengue shock syndrome10.1
45pulmonary aspergilloma10.1
46cerebritis10.1
47cushing's syndrome10.1
48melas syndrome10.1
49temporal arteritis10.1
50acute thyroiditis10.1

Graphical network of the top 20 diseases related to Invasive Aspergillosis:



Diseases related to invasive aspergillosis

Symptoms for Invasive Aspergillosis

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Drugs & Therapeutics for Invasive Aspergillosis

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Drug clinical trials:

Search ClinicalTrials for Invasive Aspergillosis

Search NIH Clinical Center for Invasive Aspergillosis

Genetic Tests for Invasive Aspergillosis

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Anatomical Context for Invasive Aspergillosis

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MalaCards organs/tissues related to Invasive Aspergillosis:

33
Lung, Testes, Liver, Myeloid, Bone, Bone marrow, Kidney, Brain, T cells, Neutrophil, Whole blood, Heart, Colon, Thyroid, Breast, Skin, Endothelial

Animal Models for Invasive Aspergillosis or affiliated genes

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MGI Mouse Phenotypes related to Invasive Aspergillosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.6PLG, IL17A, IFNG, CLEC7A, TLR4
2MP:00053888.0TLR4, SFTPD, HBB, CLEC7A, IFNG, IL17A
3MP:00053897.9TLR6, TLR4, HBB, TPMT, IFNG, PLG
4MP:00053677.1TLR4, HBB, IFNG, IL17A, PLG, CSF3
5MP:00107687.0TLR4, SFTPD, HBB, TPMT, CLEC7A, CXCL10
6MP:00053766.9TLR4, SFTPD, HBB, TPMT, CLEC7A, CXCL10
7MP:00053875.6CLEC7A, HBB, SFTPD, TLR1, TLR4, TLR6
8MP:00053975.4CD79A, TLR6, TLR4, TLR1, SFTPD, HBB

Publications for Invasive Aspergillosis

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Articles related to Invasive Aspergillosis:

(show top 50)    (show all 544)
idTitleAuthorsYear
1
Genomic analysis for single nucleotide polymorphisms (Asp299Gly and Thr399lle) in Japanese patients with invasive aspergillosis. (25766605)
2015
2
PCR in diagnosis of invasive aspergillosis: a meta-analysis of diagnostic performance. (25122854)
2014
3
Serum Galactomannan-Based Early Detection of Invasive Aspergillosis in Hematology Patients Receiving Effective Antimold Prophylaxis. (25165088)
2014
4
Refractory invasive aspergillosis controlled with posaconazole and pulmonary surgery in a patient with chronic granulomatous disease: case report. (24401677)
2014
5
Renal Infarction Secondary to Invasive Aspergillosis in a 5-Year-Old Girl With Acute Lymphoblastic Leukemia. (24136022)
2013
6
Comparison of a novel Aspergillus lateral-flow device and the PlateliaAr galactomannan assay for the diagnosis of invasive aspergillosis following haematopoietic stem cell transplantation. (23661288)
2013
7
TLR5 stop codon polymorphism is associated with invasive aspergillosis after allogeneic stem cell transplantation. (23862689)
2013
8
Widespread skin nodules as a manifestation of breakthrough invasive aspergillosis in a bone marrow transplant patient. (23381978)
2013
9
Characterization of specific immune responses to different Aspergillus antigens during the course of invasive Aspergillosis in hematologic patients. (24023936)
2013
10
Combined real-time PCR and galactomannan surveillance improves diagnosis of invasive aspergillosis in high risk patients with haematological malignancies. (23614624)
2013
11
Performance of serum biomarkers for the early detection of invasive aspergillosis in febrile, neutropenic patients: a multi-state model. (23799048)
2013
12
Clinical epidemiology of 960 patients with invasive aspergillosis from the PATH Alliance registry. (22898389)
2012
13
Invasive aspergillosis: an important risk factor on the short- and long-term survival of acute myeloid leukemia (AML) patients. (21909650)
2012
14
Invasive aspergillosis associated with pulmonary hydatid disease. (22824534)
2012
15
The role of combination antifungal therapy in the treatment of invasive aspergillosis: a systematic review. (22137271)
2012
16
Masaoka approach for invasive aspergillosis: an aggressive approach for an aggressive disease. (22916784)
2012
17
Invasive aspergillosis in children with acquired immunodeficiencies. (22075793)
2012
18
Epidemiology and antifungal resistance in invasive Aspergillosis according to primary disease: review of the literature. (21486729)
2011
19
Comparison of PCR-ELISA and Real-Time PCR for invasive aspergillosis diagnosis in patients with hematological malignancies. (21108574)
2011
20
Immunogenetics of invasive aspergillosis. (20840014)
2011
21
Invasive aspergillosis of orbit in immunocompetent patients: treatment and outcome. (21665281)
2011
22
Risk factors for invasive aspergillosis in acute myeloid leukemia patients prophylactically treated with posaconazole. (21314250)
2011
23
Invasive aspergillosis after pandemic (H1N1) 2009. (20507748)
2010
24
Adherence to international guidelines for the treatment of invasive aspergillosis in acute myeloid leukaemia: feasibility and utility (SEIFEM-2008B study). (20639313)
2010
25
Prophylaxis of invasive aspergillosis with voriconazole or caspofungin during building work in patients with acute leukemia. (20007135)
2010
26
Dectin-1 Y238X polymorphism associates with susceptibility to invasive aspergillosis in hematopoietic transplantation through impairment of both recipient- and donor-dependent mechanisms of antifungal immunity. (20807886)
2010
27
Risk stratification for invasive aspergillosis: early assessment of host susceptibility. (19253143)
2009
28
Aerosol and other novel administrations for prevention and treatment of invasive aspergillosis. (18654913)
2009
29
Invasive aspergillosis of the small bowel in an infant with acute myeloid leukemia and intestinal obstruction. (19206013)
2009
30
Invasive aspergillosis of the brain: radiologic-pathologic correlation. (19325053)
2009
31
Invasive aspergillosis in two liver transplant recipients: diagnosis by SeptiFast. (19210691)
2009
32
Diagnosis of invasive aspergillosis using bronchoalveolar lavage in haematology patients: influence of bronchoalveolar lavage human DNA content on real-time PCR performance. (18763000)
2009
33
Detection of circulating Aspergillus fumigatus DNA by real-time PCR assay of large serum volumes improves early diagnosis of invasive aspergillosis in high-risk adult patients under hematologic surveillance. (18845828)
2008
34
Invasive aspergillosis: diagnosis, prophylaxis and treatment. (18832929)
2008
35
Invasive aspergillosis in hematopoietic stem cell transplant recipients: a retrospective analysis. (19219277)
2008
36
Aortic thrombus during invasive aspergillosis in a kidney transplant recipient. (18296818)
2008
37
Molecular diagnosis of invasive aspergillosis in patients with hematologic malignancies - new answers to a diagnostic challenge? (23495815)
2008
38
Aspergillus galactomannan antigen in the bronchoalveolar lavage fluid for the diagnosis of invasive aspergillosis in lung transplant recipients. (17519782)
2007
39
Images in HIV/AIDS. Invasive aspergillosis presenting as a neck mass in a person with HIV/AIDS. (17672013)
2007
40
Invasive aspergillosis in the ICU: an emerging disease. (17646965)
2007
41
Invasive aspergillosis in chronic granulomatous disease: report of 7 cases. (16804696)
2007
42
Invasive aspergillosis of the brain: improvement with lyposomal amphoterecin B and itraconazole. (17921665)
2007
43
Disseminated invasive aspergillosis with cerebral involvement successfully treated with caspofungin and voriconazole. (17721739)
2007
44
Is combination antifungal therapy for invasive aspergillosis a necessity in hematopoietic stem-cell transplant recipients? (16804386)
2006
45
Hospital-wide prospective mandatory surveillance of invasive aspergillosis in a French teaching hospital (2000-2002). (16257084)
2006
46
Disseminated invasive aspergillosis. (17299570)
2006
47
Combination therapy with terbinafine and amphotericin B in a rabbit model of experimental invasive aspergillosis. (16251321)
2005
48
Efficacy of 2-(3,4-dimethyl-2,5-dihydro-1h-pyrrole-2-yl)-1-methylethyl pentanoate in a murine model of invasive aspergillosis. (16189123)
2005
49
Granulocyte transfusions in children with chronic granulomatous disease and invasive aspergillosis. (15828925)
2005
50
Comparison of galactomannan detection, PCR-enzyme-linked immunosorbent assay, and real-time PCR for diagnosis of invasive aspergillosis in a neutropenic rat model and effect of caspofungin acetate. (16275948)
2005

Variations for Invasive Aspergillosis

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Expression for genes affiliated with Invasive Aspergillosis

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Search GEO for disease gene expression data for Invasive Aspergillosis.

Pathways for genes affiliated with Invasive Aspergillosis

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Pathways related to Invasive Aspergillosis according to GeneCards/GeneDecks:

(show all 26)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.0TLR1, TLR6
2
Show member pathways
9.5TLR1, TLR4, TLR6
3
Show member pathways
9.5TLR1, TLR4, TLR6
49.5TLR6, TLR4, TLR1
5
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
9.3TLR6, TLR4, TLR1, CLEC7A
69.3CLEC7A, TLR1, TLR4, TLR6
7
Show member pathways
IL23-mediated signaling events38
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling38
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.3IFNG, IL17A, PLG
8
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
9.3CD79A, IL17A, IFNG
99.2TLR4, CXCL10, IFNG
10
Show member pathways
thioredoxin pathway38
9.2PLG, IFNG, HBB
119.2TLR4, IFNG, IL17A
12
Show member pathways
9.2TLR4, IFNG, IL17A
139.1CSF3, IFNG
149.1TLR6, TLR4, SFTPD, CLEC7A, MBL2
159.0IFNG, TLR1, TLR4, TLR6
16
Show member pathways
8.9PLG, IFNG, CXCL10, TLR4
17
Show member pathways
8.9CSF3, IL17A, TLR4
188.8TLR6, TLR4, TLR1, CLEC7A, IFNG
19
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
8.8TLR6, TLR4, TLR1, CXCL10, IFNG
20
Show member pathways
8.7TLR6, TLR4, TLR1, IFNG, IL17A
21
Show member pathways
IL27-mediated signaling events38
8.7TLR6, TLR4, TLR1, IFNG, IL17A
22
Show member pathways
8.7TLR6, TLR4, TLR1, IFNG, CD79A
23
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
8.5IFNG, CXCL10, SFTPD, TLR1, TLR4, TLR6
24
Show member pathways
8.5TLR6, TLR4, TLR1, CXCL10, CSF3
258.3CSF3, IFNG, HBB, TLR4
26
Show member pathways
8.1TLR4, CXCL10, IFNG, IL17A, CSF3

Compounds for genes affiliated with Invasive Aspergillosis

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Compounds related to Invasive Aspergillosis according to GeneCards/GeneDecks:

(show top 50)    (show all 82)
idCompoundScoreTop Affiliating Genes
1poly(i:c)6110.0TLR1, TLR4, TLR6
2pam3csk4619.9TLR1, TLR4, TLR6
3pam2csk4619.9TLR6, TLR1, TLR4
4resiquimod45 6110.9TLR6, TLR4, TLR1
5flagellin45 3010.8TLR6, TLR1, TLR4
6zymosan459.8CLEC7A, MBL2, TLR4
7lipoteichoic acid459.7MBL2, TLR1, TLR4
8peptidoglycan45 3010.7TLR4, TLR1, TLR6, MBL2
9tuberculin459.7IFNG, MBL2, CD79A
10con a459.6IFNG, MBL2, CD79A
111-methyltryptophan459.6IFNG, TLR4
12polymyxin b459.5TLR4, IFNG, MBL2
13imiquimod45 61 30 1312.4TLR6, TLR4, TLR1, IFNG
14polyinosinic-polycytidylic acid459.4TLR4, IFNG, CXCL10
15azathioprine45 3 51 1312.4CABIN1, TPMT, HBB, CD79A
162,5-oligoadenylate459.4IFNG, CXCL10, TLR4
17neopterin459.4CXCL10, IFNG, MBL2, CD79A
18poly(i-c)459.3TLR4, IFNG, CXCL10
19infliximab45 51 1311.3IL17A, IFNG, CXCL10, TLR4
20ifn-alpha459.3TLR4, CXCL10, IL17A, IFNG
21il 10459.1TLR4, CXCL10, IFNG
22creatinine459.1TPMT, CD79A, MBL2, CXCL10, IL17A
23allergens459.1TLR4, SFTPD, CXCL10, IFNG, CD79A
24ribavirin45 51 1311.0IFNG, CXCL10, MBL2, CSF3
25polysaccharide458.9SFTPD, MBL2, MBL3P, CD79A, TLR4
26pge2458.8CD79A, IL17A, IFNG, CXCL10, TLR4
27ccl345 309.8CSF3, TLR4, CXCL10, IFNG
28histamine45 30 2610.8SFTPD, TPMT, CXCL10, IFNG, CD79A, TLR4
29mannan458.7TLR4, MBL2, CD79A, MBL3P, IL17A, SFTPD
30mycophenolate mofetil45 51 1310.6CSF3, TPMT, CABIN1, CD79A, IFNG
31methotrexate51 45 1310.6TLR4, IL17A, CSF3, CD79A, TPMT
32glucose458.5TLR4, CLEC7A, CXCL10, PLG, SFTPD, MBL2
33lipid458.5TLR4, TLR6, MBL2, TLR1, PLG, SFTPD
34mannose458.5TLR4, CD79A, MBL3P, MBL2, IL17A, CLEC7A
35prednisolone45 30 1310.4SFTPD, TPMT, IFNG, CSF3, MBL2, CD79A
36tacrolimus45 51 1310.4TPMT, IFNG, CD79A, TLR4, CABIN1, IL17A
37steroid458.4PLG, SFTPD, HBB, TPMT, IL17A, CABIN1
38endotoxin458.3TLR4, SFTPD, IL17A, CXCL10, IFNG, CSF3
39anti-fungal458.3CD79A, MBL2, IFNG, SFTPD, TLR4, CSF3
40cysteine458.2IFNG, HBB, MBL2, CD79A, SFTPD, TLR4
41atp45 309.2HBB, PLG, TPMT, CXCL10, MBL2, TLR4
42rantes458.0MBL2, IL17A, CSF3, IFNG, CXCL10, TLR6
43cycloheximide458.0TLR4, CXCL10, CSF3, IFNG, HBB
44thymidine45 269.0IFNG, SFTPD, CSF3, HBB, CXCL10, IL17A
45cyclosporin a45 30 619.8TPMT, TLR4, IL17A, CSF3, CABIN1, CD79A
46nitric oxide45 26 139.8MBL2, TLR4, SFTPD, HBB, CXCL10, IL17A
47calcium45 51 26 1310.7PLB1, TLR4, SFTPD, HBB, CXCL10, MBL2
48vegf457.5CSF3, CD79A, PLG, CXCL10, IFNG, TLR4
49tyrosine457.5CLEC7A, IL17A, CSF3, TLR4, HBB, MBL2
50dexamethasone45 51 30 1310.5MBL2, IL17A, IFNG, CXCL10, TLR4, CLEC7A

GO Terms for genes affiliated with Invasive Aspergillosis

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Cellular components related to Invasive Aspergillosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.5MBL2, PLG, IFNG, CXCL10, HBB, SFTPD
2external side of plasma membraneGO:00098978.2CD79A, IL17A, IFNG, CXCL10, CLEC7A, TLR4
3extracellular spaceGO:00056157.4SFTPD, CXCL10, IFNG, IL17A, PLG, CSF3

Biological processes related to Invasive Aspergillosis according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1detection of triacyl bacterial lipopeptideGO:004249510.3TLR1, TLR6
2positive regulation of phagocytosisGO:005076610.1MBL2, CLEC7A, SFTPD
3macrophage activationGO:004211610.0TLR4, TLR1
4positive regulation of tumor necrosis factor biosynthetic processGO:004253510.0TLR4, TLR1
5T-helper 1 type immune responseGO:00420889.9TLR4, TLR6
6positive regulation of interleukin-23 productionGO:00327479.9IFNG, IL17A
7positive regulation of interleukin-6 biosynthetic processGO:00454109.8IFNG, TLR1, TLR6
8negative regulation of growth of symbiont in hostGO:00441309.8MBL2, IFNG
9positive regulation of MHC class II biosynthetic processGO:00453489.8TLR4, IFNG
10positive regulation of interleukin-12 biosynthetic processGO:00450849.8TLR4, IFNG
11defense response to protozoanGO:00428329.7CLEC7A, IFNG
12negative regulation of interleukin-17 productionGO:00327009.7TLR4, IFNG
13toll-like receptor signaling pathwayGO:00022249.7TLR1, TLR4, TLR6
14positive regulation of tumor necrosis factor productionGO:00327609.6TLR4, CLEC7A, IFNG
15inflammatory responseGO:00069549.5TLR6, TLR1, CLEC7A, CXCL10, IL17A
16positive regulation of osteoclast differentiationGO:00456729.5IL17A, IFNG
17positive regulation of interleukin-12 productionGO:00327359.5IFNG, TLR4
18positive regulation of nitric oxide biosynthetic processGO:00454299.4IFNG, HBB, TLR4
19innate immune responseGO:00450879.2TLR6, TLR4, TLR1, SFTPD, CLEC7A, MBL2
20defense response to bacteriumGO:00427429.2MBL2, IFNG, SFTPD, TLR4, TLR6
21cell surface receptor signaling pathwayGO:00071669.1CABIN1, IFNG, CXCL10
22cellular response to lipopolysaccharideGO:00712229.0CSF3, IFNG, TLR4
23immune responseGO:00069558.5TLR6, TLR4, TLR1, CXCL10, IL17A, CSF3
24positive regulation of transcription from RNA polymerase II promoterGO:00459448.3CSF3, IL17A, IFNG, CXCL10, TLR4

Molecular functions related to Invasive Aspergillosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane signaling receptor activityGO:00048888.9CD79A, TLR1, TLR4, TLR6
2cytokine activityGO:00051258.8CSF3, IL17A, IFNG

Products for genes affiliated with Invasive Aspergillosis

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Sources for Invasive Aspergillosis

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet