MCID: INV001
MIFTS: 47

Invasive Aspergillosis malady

Categories: Infectious diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Invasive Aspergillosis

Aliases & Descriptions for Invasive Aspergillosis:

Name: Invasive Aspergillosis 12 14 69
Aspergillosis Invasive 52

Classifications:



External Ids:

Disease Ontology 12 DOID:0050073

Summaries for Invasive Aspergillosis

Disease Ontology : 12 An aspergillosis that is a serious fungal infection of the lung with pneumonia caused by Aspergillus, which spreads to other parts of the body through bloodstream in patients with acute leukemia and recipients of tissue transplants. Clinical symptoms include pulmonary nodules and hemorrhage.

MalaCards based summary : Invasive Aspergillosis, also known as aspergillosis invasive, is related to rheumatoid arthritis and aspergillosis. An important gene associated with Invasive Aspergillosis is CLEC7A (C-Type Lectin Domain Containing 7A), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Amphotericin B and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and liver, and related phenotypes are hematopoietic system and immune system

Related Diseases for Invasive Aspergillosis

Diseases in the Aspergillosis family:

Invasive Aspergillosis

Diseases related to Invasive Aspergillosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 170)
id Related Disease Score Top Affiliating Genes
1 rheumatoid arthritis 29.0 CD79A CXCL8 IFNG TLR2 TLR4
2 aspergillosis 11.7
3 paralytic poliomyelitis 10.3 IFNG TLR4
4 malignant renovascular hypertension 10.2 CD79A IFNG
5 hematopoietic stem cell transplantation 10.2
6 gonococcal synovitis 10.2 CLEC7A MBL2 TLR4
7 leukemia 10.2
8 indomethacin antenatal infection 10.2 CD79A MBL2
9 mesangial proliferative glomerulonephritis 10.2 CD79A CXCL8
10 coronary arterial fistulas 10.2 CXCL8 TLR4
11 parkinson disease 11 10.2 CXCL8 IFNG TLR4
12 myiasis 10.2 CXCL8 IFNG TLR4
13 gonadal disease 10.2 CD79A CLEC7A MBL2
14 motor peripheral neuropathy 10.2 CD79A CLEC7A IFNG
15 myeloid proliferations related to down syndrome 10.2 CXCL8 TLR2
16 benign eccrine breast spiradenoma 10.2 CXCL8 IFNG TLR4
17 ritscher-schinzel syndrome 1 10.1 CD79A CXCL8
18 plantar wart 10.1 CD79A CXCL8 IFNG
19 bare lymphocyte syndrome, type i 10.1 CXCL8 IFNG TLR4
20 myoclonic astatic epilepsy 10.1 CXCL8 TLR2
21 omsk hemorrhagic fever 10.1 CD79A CXCL8 TLR4
22 polyarteritis nodosa 10.1 IFNG TLR2 TLR4
23 pseudoainhum 10.1 MBL2 TLR2 TLR4
24 nasopharyngitis 10.1 CD79A CXCL8 IFNG
25 tracheitis 10.1 CD79A CXCL8 IFNG
26 oral cavity carcinoma in situ 10.1 IFNG MBL2 TLR2
27 nephropathy familial with hyperuricemia 10.1 MBL2 TLR2 TLR4
28 handl syndrome 10.1 CLEC7A CXCL8 TLR2
29 dengue hemorrhagic fever 10.1 IFNG TLR2 TLR4
30 liver inflammatory pseudotumor 10.1 IFNG TLR2 TLR4
31 appendiceal l-cell glucagon-like peptide producing tumor 10.1 CXCL8 TLR2 TLR4
32 bone angioendothelial sarcoma 10.1 CD79A CXCL8 IFNG
33 metachronous kidney wilms' tumor 10.1 CABIN1 CD79A
34 inappropriate adh syndrome 10.1 CXCL8 TLR2 TLR4
35 chronic gonorrhea of cervix 10.1 CD79A CLEC7A IFNG MBL2
36 dengue disease 10.1 CD79A IFNG TLR4
37 spotted fever 10.1 TLR2 TLR4
38 wagr syndrome 10.1 CXCL8 IFNG TLR4
39 disease of mental health 10.1 CD79A IFNG TLR2
40 periarthritis 10.1 IFNG MBL2 TLR2
41 unilateral hypoactive labyrinth 10.1 CXCL8 TLR2 TLR4
42 pulmonary tuberculosis 10.1 CXCL8 IFNG TLR4 TLR6
43 fallopian tube carcinoma 10.1 CD79A CXCL8
44 malignant neoplasm of acoustic nerve 10.0 CXCL8 IFNG SFTPD
45 fasciitis 10.0 CXCL8 MBL2 TLR2
46 sclerosing adenosis of breast 10.0 CXCL8 IFNG TLR2
47 immunodeficiency due to a late component of complement deficiency 10.0 CXCL10 CXCL8 IFNG
48 pigmentation disease 10.0 CXCL8 IFNG TLR2
49 mixed mineral dust pneumoconiosis 10.0 CXCL10 CXCL8 IFNG
50 nguyen syndrome 10.0 TLR1 TLR2 TLR6

Graphical network of the top 20 diseases related to Invasive Aspergillosis:



Diseases related to Invasive Aspergillosis

Symptoms & Phenotypes for Invasive Aspergillosis

MGI Mouse Phenotypes related to Invasive Aspergillosis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.93 CABIN1 CD79A CLEC7A CXCL10 IFNG IL12B
2 immune system MP:0005387 9.73 MBL2 SFTPD TLR1 TLR2 TLR4 TLR6
3 respiratory system MP:0005388 9.1 CLEC7A IFNG IL12B SFTPD TLR2 TLR4

Drugs & Therapeutics for Invasive Aspergillosis

Drugs for Invasive Aspergillosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 90)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amphotericin B Approved, Investigational Phase 4,Phase 2,Phase 3 1397-89-3 14956 5280965
2
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
3
Voriconazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 137234-62-9 71616
4
Caspofungin Approved Phase 4,Phase 3,Phase 2,Phase 1 179463-17-3, 162808-62-0 468682 2826718
5
Anidulafungin Approved, Investigational Phase 4,Phase 3,Phase 2 166663-25-8 166548
6
Posaconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 171228-49-2 147912
7
Micafungin Approved, Investigational Phase 4,Phase 3,Phase 2 235114-32-6 3081921 477468
8
Itraconazole Approved, Investigational Phase 4,Phase 2 84625-61-6 55283
9
Mycophenolate mofetil Approved, Investigational Phase 4 128794-94-5 5281078
10
Mycophenolic acid Approved Phase 4 24280-93-1 446541
11
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
12 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2
13 Antifungal Agents Phase 4,Phase 3,Phase 2,Phase 1
14 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
15 Antiparasitic Agents Phase 4,Phase 2,Phase 3,Phase 1
16 Antiprotozoal Agents Phase 4,Phase 2,Phase 3,Phase 1
17 Liposomal amphotericin B Phase 4,Phase 2,Phase 3
18 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
19 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
20 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
21 Hormones Phase 4,Phase 3,Phase 2,Phase 1
22 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
23 Steroid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
24 Echinocandins Phase 4,Phase 3,Phase 2,Phase 1
25 Pharmaceutical Solutions Phase 4,Phase 3
26 Cytochrome P-450 CYP2C9 Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
27 glucocorticoids Phase 4,Phase 3
28 Hydroxyitraconazole Phase 4,Phase 2
29 Immunosuppressive Agents Phase 4,Phase 1
30
Midazolam Approved, Illicit Phase 2, Phase 3,Phase 1 59467-70-8 4192
31
deoxycholic acid Approved Phase 3 83-44-3 222528
32
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
33
Fluconazole Approved Phase 3,Phase 1 86386-73-4 3365
34 Amphotericin B, deoxycholate drug combination Phase 3
35 Cholagogues and Choleretics Phase 3
36 Gastrointestinal Agents Phase 3,Phase 1
37 Antiemetics Phase 3
38 Anti-Inflammatory Agents Phase 3
39 Antineoplastic Agents, Hormonal Phase 3
40 Autonomic Agents Phase 3
41 BB 1101 Phase 3
42 Dexamethasone 21-phosphate Phase 3
43 Dexamethasone acetate Phase 3 1177-87-3
44 HIV Protease Inhibitors Phase 3
45 Peripheral Nervous System Agents Phase 3
46
protease inhibitors Phase 3
47 Liver Extracts Phase 2
48 Antiviral Agents Phase 2
49 Interferon-gamma Phase 2
50 interferons Phase 2

Interventional clinical trials:

(show top 50) (show all 117)
id Name Status NCT ID Phase
1 Aspergillus PCR Early Detection in High Risk Oncohematological Patients Unknown status NCT01742026 Phase 4
2 Value of Amphotericin B Inhalation for Prophylaxis of Invasive Pulmonary Aspergillosis After Renal Transplantation Unknown status NCT00986713 Phase 4
3 Voriconazole for IPA in Chinese Patients With COPD Unknown status NCT02234739 Phase 4
4 Efficacy and Safety of Caspofungin for Invasive Pulmonary Aspergillosis Underlying Chronic Obstructive Pulmonary Disease Unknown status NCT01499433 Phase 4
5 COMBISTRAT: AmBisome® in Combination With Caspofungin for the Treatment of Invasive Aspergillosis Completed NCT00334412 Phase 4
6 Acetato de Caspofungin (Cancidas®) in the Treatment of Fungal Infection Completed NCT00388167 Phase 4
7 A Study of the Efficacy and Safety of Voriconazole for the Treatment of Fungal Infections Completed NCT00647907 Phase 4
8 A Study To Assess The Anidulafungin And Voriconazole Concentration In Lung Following Intravenous Administration In Healthy Subjects Completed NCT00940017 Phase 4
9 King's Invasive Aspergillosis Study II Not yet recruiting NCT02875743 Phase 4
10 Study to Test the Combination of Voriconazole and Anidulafungin in Patients Who Have, or Are Thought to Have, Invasive Aspergillosis and Who Are Unable to Take a Common Antifungal Therapy (Polyene) Terminated NCT00620074 Phase 4
11 Post Marketing Study to Evaluate the Efficacy and Safety of Micafungin Treatment on Invasive Aspergillosis Terminated NCT02646774 Phase 4
12 Evaluation of Antifungal Prophylaxis on Graft-versus-host Disease (GVHD) Patients Terminated NCT01282879 Phase 4
13 A Study to Evaluate the Effectiveness of Voriconazole + Micafungin Versus Voriconazole Alone for Invasive Aspergillosis Withdrawn NCT00423163 Phase 4
14 Posaconazole as Salvage Therapy for Aspergillus Pulmonary Infection. Withdrawn NCT02020213 Phase 4
15 A Multicentre Randomised Controlled Trial Comparing Two Strategies for the Diagnosis of Invasive Aspergillosis in High-risk Haematology Patients Completed NCT00163722 Phase 3
16 Anidulafungin Plus Voriconazole Versus Voriconazole For The Treatment Of Invasive Aspergillosis Completed NCT00531479 Phase 3
17 A Safety & Effectiveness Study of Intravenous Anidulafungin With AmBisome® for Treatment of Invasive Aspergillosis (IA). Completed NCT00037206 Phase 2, Phase 3
18 Voriconazole vs. Amphotericin B in the Treatment of Invasive Aspergillosis Completed NCT00001646 Phase 3
19 Study Safety/Efficacy of AmBisome Loading Dose Regimen Versus Standard AmBisome Regimen for Initial Treatment Completed NCT00158730 Phase 3
20 Isavuconazole (BAL8557) for Primary Treatment of Invasive Aspergillosis Completed NCT00412893 Phase 3
21 Inhalation of Liposomal Amphotericin B to Prevent Invasive Aspergillosis Completed NCT00263315 Phase 2, Phase 3
22 Comparison of Voriconazole and Amphotericin B in Treating Patients With Aspergillosis Completed NCT00003031 Phase 3
23 Pharmacokinetic Profiles of Inhaled Lipid Complex Amphotericin B (Abelcet ®) Completed NCT00177684 Phase 3
24 Safety and Effectiveness of Granulocyte Transfusions in Resolving Infection in People With Neutropenia (The RING Study) Completed NCT00627393 Phase 3
25 Isavuconazole in the Treatment of Renally Impaired Aspergillosis and Rare Fungi Completed NCT00634049 Phase 3
26 An Open Label, Non-Comparative, Multicenter, Phase III Trial of the Efficacy, Safety and Toleration of Voriconazole in the Primary or Secondary Treatment of Invasive Fungal Infections Completed NCT00001810 Phase 3
27 Open Label Study of Posaconazole in the Treatment of Invasive Fungal Infections (Study P00041) Completed NCT00034658 Phase 3
28 Study of Posaconazole in the Treatment of Invasive Fungal Infections (Study P02095) Completed NCT00034632 Phase 3
29 An Open Label, Non-Comparative, Multicenter, Phase III Trial of the Efficacy, Safety and Toleration of Voriconazole in the Primary or Secondary Treatment of Invasive Fungal Infections Completed NCT00001757 Phase 3
30 Voriconazole to Treat Fungal Infections Completed NCT00001940 Phase 3
31 A Clinical Study of MK0991 (Caspofungin) in Japanese Patients With Deep-seated Candida or Aspergillus Infections (0991-062)(COMPLETED) Completed NCT00717860 Phase 3
32 A Study of the Safety and Efficacy of Posaconazole Versus Voriconazole for the Treatment of Invasive Aspergillosis (MK-5592-069) Recruiting NCT01782131 Phase 3
33 Assessing the Safety and Efficacy of MK-5592 (Posaconazole) in Japanese Participants With Fungal Infection (MK-5592-101) Recruiting NCT02180165 Phase 3
34 Caspofungin Acetate or Fluconazole in Preventing Invasive Fungal Infections in Patients With Acute Myeloid Leukemia Who Are Undergoing Chemotherapy Active, not recruiting NCT01307579 Phase 3
35 A Study To Evaluate The Safety Of Voriconazole As Treatment Of Invasive Aspergillosis (Fungal Infection) And Other Rare Molds In Children Terminated NCT00836875 Phase 3
36 To Determine Whether Galactomannan Test Will Help to Detect Fungal Infections Early and Hence Start Treatment Early Terminated NCT00361517 Phase 3
37 Voriconazole And Anidulafungin Combination For Invasive Aspergillosis In Pediatric Subjects Withdrawn NCT01188759 Phase 3
38 Prophylaxis With Caspofungin in High-Risk Liver Transplantation Unknown status NCT00333645 Phase 2
39 Caspofungin Maximum Tolerated Dose in Patients With Invasive Aspergillosis Completed NCT00404092 Phase 2
40 MK0991 in Combination With Standard Antifungal Agent(s) for the Treatment of Salvage Invasive Aspergillosis (0991-037) Completed NCT00076869 Phase 2
41 Study of FK463 for the Treatment of Invasive Aspergillosis Completed NCT00036166 Phase 2
42 Voriconazole With or Without Interferon Gamma in Treating Patients With Aspergillosis or Other Fungal Infections Completed NCT00059878 Phase 2
43 Caspofungin Acetate in Treating Aspergillosis in Patients With Hematologic Cancer or in Patients Who Have Undergone a Stem Cell Transplant Completed NCT00110045 Phase 2
44 Prophylaxis of Fungal Invasive Infections in Leukemia Completed NCT00501098 Phase 2
45 Nebulized Liposomal Amphotericin B Ambisome for Prophylaxis of Invasive Pulmonary Aspergillosis Completed NCT00391014 Phase 2
46 Nebulized Amphotericin B Lipid Complex in Invasive Pulmonary Aspergillosis in Paediatric Patients With Acute Leukaemia Completed NCT01615809 Phase 2
47 A Study of Caspofungin (MK-0991) in Japanese Children and Adolescents With Documented Candida or Aspergillus Infections (MK-0991-074) Completed NCT01165320 Phase 2
48 PK/PD Study of Posaconazole for Empiric Treatment of Invasive Fungal Infections in Neutropenic Patients or Treatment of Refractory Invasive Fungal Infections (Study P01893) Completed NCT00034671 Phase 2
49 Itraconazole for the Prevention of Fungal Infections in Chronic Granulomatous Disease Completed NCT00001280 Phase 2
50 Pharmacokinetic, Safety and Efficacy of Intermittent Application of Caspofungin for Antifungal Prophylaxis Completed NCT01318148 Phase 2

Search NIH Clinical Center for Invasive Aspergillosis

Genetic Tests for Invasive Aspergillosis

Anatomical Context for Invasive Aspergillosis

MalaCards organs/tissues related to Invasive Aspergillosis:

39
Lung, Testes, Liver, Myeloid, Bone, Kidney, Bone Marrow

Publications for Invasive Aspergillosis

Articles related to Invasive Aspergillosis:

(show top 50) (show all 628)
id Title Authors Year
1
Utility of the serum galactomannan assay for the diagnosis of invasive aspergillosis in children with acute lymphoblastic leukemia. ( 27815226 )
2017
2
Prospective Biomarker Screening for Diagnosis of Invasive Aspergillosis in High-Risk Pediatric Patients. ( 27795339 )
2017
3
Cost-Effectiveness Analysis of Isavuconazole vs. Voriconazole as First-Line Treatment for Invasive Aspergillosis. ( 27913989 )
2017
4
Nosocomial legionellosis and invasive aspergillosis in a child with T-lymphoblastic leukemia. ( 28529020 )
2017
5
Invasive aspergillosis in acute myeloid leukemia: Are we making progress in reducing mortality? ( 27915304 )
2017
6
PCR-based detection of Aspergillus fumigatus Cyp51A mutations on bronchoalveolar lavage: a multicentre validation of the AsperGenius assayAr in 201 patients with haematological disease suspected for invasive aspergillosis. ( 27530755 )
2016
7
New therapeutic strategies for invasive aspergillosis in the era of azole resistance: how should the prevalence of azole resistance be defined? ( 27494830 )
2016
8
Sequential Sonographic Features of Primary Invasive Aspergillosis Involving Only the Thyroid Gland: A Case Report and Literature Review. ( 27110341 )
2016
9
Invasive Aspergillosis Mimicking Sphenoid Wing Meningioma. ( 27977495 )
2016
10
Neonatal Cutaneous Invasive Aspergillosis Accompanied by Hemophagocytic Lymphohistocytosis. ( 27977554 )
2016
11
The influence of the control group characteristics for the diagnostic performance of 1,3-beta-D-glucan in invasive aspergillosis. ( 27663204 )
2016
12
Invasive Aspergillosis of the Stomach and Co-infection With Candida krusei in a Patient With Terminal Liver Failure: A Case Report. ( 27932169 )
2016
13
Safety, Efficacy, and Exposure-Response of Voriconazole in Pediatric Patients with Invasive Aspergillosis, Invasive Candidiasis, or Esophageal Candidiasis. ( 27636722 )
2016
14
Combination Antifungal Therapy for Invasive Aspergillosis Revisited. ( 27441304 )
2016
15
Blood Aspergillus RNA is a promising alternative biomarker for invasive aspergillosis. ( 27335056 )
2016
16
Invasive aspergillosis successfully treated by combined antifungal therapy and immunosuppressive monotherapy two months following heart transplantation. ( 27516796 )
2016
17
Polymorphisms in Host Immunity-Modulating Genes and Risk of Invasive Aspergillosis: Results from the AspBIOmics Consortium. ( 26667837 )
2016
18
Invasive aspergillosis presenting as an intracardiac mass in an immunocompetent host. ( 26944369 )
2016
19
Aspergillus PCR in serum for the diagnosis, follow-up and prognosis of invasive aspergillosis in neutropenic and nonneutropenic patients. ( 26899830 )
2016
20
Cutaneous invasive aspergillosis in a patient with glioblastoma receiving long-term temozolomide and corticosteroid therapy. ( 27889247 )
2016
21
Guideline recommendations for the prophylaxis of invasive aspergillosis in AML. ( 27930638 )
2016
22
Galactomannan in bronchoalveolar lavage fluid for diagnosis of invasive aspergillosis in non-hematological patients. ( 27025205 )
2016
23
Common Genetic Polymorphisms within NFI_B-Related Genes and the Risk of Developing Invasive Aspergillosis. ( 27570521 )
2016
24
A rare case of invasive aspergillosis as a cause of superior vena cava syndrome. ( 27728645 )
2016
25
Management of invasive Aspergillosis in acute myelogenous leukemia. ( 27379944 )
2016
26
A rare disease mimics postoperative bile leakage: Invasive aspergillosis. ( 27849329 )
2016
27
Changes of serum aspergillus galactomannan during hematopoietic stem cell transplantation in children with prior invasive aspergillosis. ( 26960808 )
2016
28
Development and evaluation of enzyme-linked immunosorbent assay of nucleic acid sequence-based amplification for diagnosis of invasive aspergillosis. ( 27714704 )
2016
29
A prospective observational study of CYP2C19 polymorphisms and voriconazole plasma level in adult Thai patients with invasive aspergillosis. ( 26861072 )
2016
30
An unusual presentation of invasive Aspergillosis; diagnostic and management dilemmas. ( 27728425 )
2016
31
New advances in invasive aspergillosis immunobiology leading the way towards personalized therapeutic approaches. ( 27253487 )
2016
32
Galactomannan testing and Aspergillus PCR in same-day bronchoalveolar lavage and blood samples for diagnosis of invasive aspergillosis. ( 27744310 )
2016
33
Invasive Aspergillosis in Hematological Patients. ( 27251320 )
2016
34
Proteomic Profiling of Serological Responses to Aspergillus fumigatus Antigens in Patients with Invasive Aspergillosis. ( 26974881 )
2016
35
Clinical Features and Survival Outcomes of Invasive Aspergillosis in Pediatric Patients at a Medical School in Thailand. ( 27249894 )
2016
36
Comparison of galactomannan, beta-D-glucan, and Aspergillus DNA in sera of high-risk adult patients with hematological malignancies for the diagnosis of invasive aspergillosis. ( 27511494 )
2016
37
The Plasmair Decontamination System Is Protective Against Invasive Aspergillosis in Neutropenic Patients. ( 27340735 )
2016
38
Isavuconazole for the treatment of invasive aspergillosis and mucormycosis: current evidence, safety, efficacy, and clinical recommendations. ( 27994475 )
2016
39
Tacrolimus successfully used to control refractory eosinophilic granulomatosis with polyangiitis complicated by invasive aspergillosis and chronic hepatitis B. ( 27125472 )
2016
40
Isavuconazole: A Review in Invasive Aspergillosis and Mucormycosis. ( 27766566 )
2016
41
Prognosis of Invasive Aspergillosis in Kidney Transplant Recipients: A Case-Control Study. ( 27819031 )
2016
42
Improving case finding of invasive aspergillosis in children using string searches. ( 27375058 )
2016
43
Orbital Apex Syndrome Caused by Invasive Aspergillosis as an Adverse Effect of Systemic Chemotherapy for Metastatic Colorectal Cancer: a Case Report. ( 26851046 )
2016
44
Correction: Detection of a Serum Siderophore by LC-MS/ MS as a Potential Biomarker of Invasive Aspergillosis. ( 27163443 )
2016
45
Invasive Aspergillosis: Current Strategies for Diagnosis and Management. ( 26897064 )
2016
46
Detection of a Serum Siderophore by LC-MS/MS as a Potential Biomarker of Invasive Aspergillosis. ( 26974544 )
2016
47
Invasive aspergillosis in a paediatric allogeneic stem cell transplantation recipient owing to a susceptible Aspergillus fumigatus: Treatment failure with high doses of voriconazole and influence of CYP2C19 polymorphisms. ( 27056297 )
2016
48
Domestic mould exposure and invasive aspergillosis-air sampling of Aspergillus spp. spores in homes of hematological patients, a pilot study. ( 26941254 )
2016
49
A retrospective study of the epidemiology and clinical manifestation of invasive aspergillosis in a major tertiary care hospital in Bahrain. ( 27033677 )
2016
50
A CONSORT analysis of randomised controlled trials for the treatment of invasive aspergillosis. ( 27915306 )
2016

Variations for Invasive Aspergillosis

Expression for Invasive Aspergillosis

Search GEO for disease gene expression data for Invasive Aspergillosis.

Pathways for Invasive Aspergillosis

Pathways related to Invasive Aspergillosis according to GeneCards Suite gene sharing:

(show all 38)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.9 CD79A CLEC7A CXCL10 CXCL8 IFNG IL12B
2
Show member pathways
13.32 CXCL10 CXCL8 IL12B TLR1 TLR2 TLR4
3
Show member pathways
13.1 CD79A IFNG TLR1 TLR2 TLR4 TLR6
4
Show member pathways
12.92 CLEC7A CXCL8 TLR1 TLR2 TLR4 TLR6
5
Show member pathways
12.72 CXCL10 CXCL8 IFNG IL12B TLR2 TLR4
6
Show member pathways
12.62 CXCL10 CXCL8 IFNG IL12B
7
Show member pathways
12.59 TLR1 TLR2 TLR4 TLR6
8
Show member pathways
12.55 IL12B TLR1 TLR2 TLR4 TLR6
9
Show member pathways
12.5 IFNG IL12B TLR2 TLR4
10
Show member pathways
12.43 CXCL10 CXCL8 IFNG IL12B MBL2 SFTPD
11 12.41 CABIN1 CD79A CXCL10 IFNG TLR1 TLR2
12
Show member pathways
12.4 TLR1 TLR2 TLR4 TLR6
13
Show member pathways
12.27 CXCL10 CXCL8 IFNG TLR2
14
Show member pathways
12.21 CXCL8 TLR1 TLR2 TLR4 TLR6
15
Show member pathways
12.19 IFNG IL12B TLR2 TLR4
16
Show member pathways
12.15 CXCL8 IFNG TLR4
17 12.14 IFNG TLR1 TLR2 TLR4 TLR6
18 12.06 CLEC7A MBL2 SFTPD TLR2 TLR4 TLR6
19
Show member pathways
12.05 CXCL8 IFNG IL12B
20 12.03 TLR1 TLR2 TLR4 TLR6
21
Show member pathways
11.99 TLR1 TLR2 TLR4 TLR6
22 11.96 CXCL10 CXCL8 IFNG TLR4
23 11.95 CLEC7A IFNG IL12B TLR1 TLR2 TLR4
24 11.84 CXCL8 IFNG IL12B TLR2 TLR4
25
Show member pathways
11.83 IFNG IL12B TLR1 TLR2 TLR4 TLR6
26 11.81 CXCL8 IFNG TLR2 TLR4
27
Show member pathways
11.8 CXCL8 IL12B TLR4
28 11.77 CXCL8 IFNG TLR4
29 11.76 CLEC7A TLR1 TLR2 TLR4 TLR6
30
Show member pathways
11.74 IFNG IL12B TLR1 TLR2 TLR4 TLR6
31
Show member pathways
11.7 CABIN1 CXCL8 IFNG
32 11.7 CXCL8 IL12B TLR4
33 11.55 CXCL8 IL12B TLR2 TLR4
34 11.49 CXCL8 IFNG TLR2 TLR4
35 11.48 CXCL10 CXCL8 IL12B
36 11.46 IFNG IL12B TLR2 TLR4
37
Show member pathways
11.44 CXCL10 CXCL8 IFNG SFTPD TLR1 TLR2
38 11.15 IFNG TLR1 TLR2

GO Terms for Invasive Aspergillosis

Cellular components related to Invasive Aspergillosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.8 CXCL10 CXCL8 IFNG IL12B MBL2 SFTPD
2 external side of plasma membrane GO:0009897 9.56 CD79A CXCL10 IFNG TLR4
3 phagocytic vesicle membrane GO:0030670 9.33 TLR1 TLR2 TLR6
4 membrane raft GO:0045121 9.26 CD79A TLR1 TLR2 TLR6
5 Toll-like receptor 1-Toll-like receptor 2 protein complex GO:0035354 8.62 TLR1 TLR2

Biological processes related to Invasive Aspergillosis according to GeneCards Suite gene sharing:

(show all 48)
id Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.98 CABIN1 CD79A CXCL10 IFNG IL12B
2 immune response GO:0006955 9.98 CXCL10 CXCL8 IFNG TLR1 TLR2 TLR4
3 cellular response to lipopolysaccharide GO:0071222 9.88 CXCL10 CXCL8 IFNG IL12B TLR4
4 cell cycle arrest GO:0007050 9.87 CXCL8 IFNG IL12B
5 defense response GO:0006952 9.87 CXCL10 CXCL8 TLR1
6 defense response to bacterium GO:0042742 9.85 IFNG MBL2 SFTPD TLR1 TLR4 TLR6
7 positive regulation of inflammatory response GO:0050729 9.82 IL12B TLR2 TLR4
8 positive regulation of tumor necrosis factor production GO:0032760 9.81 IFNG IL12B TLR2 TLR4
9 inflammatory response GO:0006954 9.8 CLEC7A CXCL10 CXCL8 TLR1 TLR2 TLR4
10 positive regulation of interleukin-10 production GO:0032733 9.77 IL12B TLR2 TLR4
11 positive regulation of NF-kappaB import into nucleus GO:0042346 9.75 IL12B TLR2 TLR4
12 defense response to protozoan GO:0042832 9.74 CLEC7A IFNG IL12B
13 negative regulation of growth of symbiont in host GO:0044130 9.73 IFNG IL12B MBL2
14 cell activation GO:0001775 9.72 TLR1 TLR2 TLR6
15 T-helper 1 type immune response GO:0042088 9.71 IL12B TLR4 TLR6
16 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.71 TLR1 TLR2 TLR4 TLR6
17 positive regulation of interferon-beta production GO:0032728 9.7 TLR2 TLR4
18 positive regulation of interleukin-8 production GO:0032757 9.7 TLR2 TLR4
19 positive regulation of osteoclast differentiation GO:0045672 9.7 IFNG IL12B
20 negative regulation of interleukin-17 production GO:0032700 9.7 IFNG IL12B TLR4
21 positive regulation of chemokine production GO:0032722 9.69 TLR2 TLR4
22 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.69 TLR2 TLR4
23 microglial cell activation GO:0001774 9.68 TLR2 TLR6
24 response to molecule of bacterial origin GO:0002237 9.68 CXCL8 TLR2
25 I-kappaB phosphorylation GO:0007252 9.68 TLR2 TLR4
26 positive regulation of tumor necrosis factor biosynthetic process GO:0042535 9.68 TLR1 TLR4
27 macrophage activation GO:0042116 9.67 TLR1 TLR4
28 positive regulation of smooth muscle cell apoptotic process GO:0034393 9.67 IFNG IL12B
29 cellular response to lipoteichoic acid GO:0071223 9.67 TLR2 TLR4
30 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.67 IFNG TLR1 TLR6
31 interleukin-1 beta secretion GO:0050702 9.66 TLR4 TLR6
32 positive regulation of lymphocyte proliferation GO:0050671 9.66 IL12B TLR4
33 positive regulation of MHC class II biosynthetic process GO:0045348 9.65 IFNG TLR4
34 positive regulation of interleukin-12 biosynthetic process GO:0045084 9.65 IFNG TLR4
35 positive regulation of NLRP3 inflammasome complex assembly GO:1900227 9.64 TLR4 TLR6
36 cellular response to diacyl bacterial lipopeptide GO:0071726 9.64 TLR2 TLR6
37 toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 9.63 TLR2 TLR6
38 cellular response to triacyl bacterial lipopeptide GO:0071727 9.63 TLR1 TLR2
39 nitric oxide metabolic process GO:0046209 9.62 TLR2 TLR6
40 toll-like receptor TLR1:TLR2 signaling pathway GO:0038123 9.62 TLR1 TLR2
41 positive regulation of interleukin-12 production GO:0032735 9.62 IFNG IL12B TLR2 TLR4
42 detection of diacyl bacterial lipopeptide GO:0042496 9.61 TLR2 TLR6
43 detection of triacyl bacterial lipopeptide GO:0042495 9.61 TLR1 TLR2
44 response to bacterial lipoprotein GO:0032493 9.6 TLR2 TLR6
45 regulation of cytokine secretion GO:0050707 9.46 TLR1 TLR2 TLR4 TLR6
46 toll-like receptor signaling pathway GO:0002224 9.35 SFTPD TLR1 TLR2 TLR4 TLR6
47 immune system process GO:0002376 9.23 CD79A CLEC7A MBL2 SFTPD TLR1 TLR2
48 innate immune response GO:0045087 10 CLEC7A MBL2 SFTPD TLR1 TLR2 TLR4

Molecular functions related to Invasive Aspergillosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 receptor activity GO:0004872 9.67 TLR1 TLR2 TLR4 TLR6
2 cytokine activity GO:0005125 9.62 CXCL10 CXCL8 IFNG IL12B
3 lipopolysaccharide binding GO:0001530 9.43 TLR2 TLR4
4 signaling pattern recognition receptor activity GO:0008329 9.4 CLEC7A TLR2
5 transmembrane signaling receptor activity GO:0004888 9.35 CD79A TLR1 TLR2 TLR4 TLR6
6 lipopolysaccharide receptor activity GO:0001875 9.26 TLR2 TLR4
7 Toll-like receptor 2 binding GO:0035663 9.16 TLR1 TLR6
8 lipopeptide binding GO:0071723 8.8 TLR1 TLR2 TLR6

Sources for Invasive Aspergillosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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