MCID: INV001
MIFTS: 52

Invasive Aspergillosis malady

Infectious diseases category

Summaries for Invasive Aspergillosis

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9Disease Ontology, 34MalaCards
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Disease Ontology:9 An aspergillosis that is a serious fungal infection of the lung with pneumonia caused by aspergillus, which spreads to other parts of the body through bloodstream in patients with acute leukemia and recipients of tissue transplants. clinical symptoms include pulmonary nodules and hemorrhage.

MalaCards: Invasive Aspergillosis, also known as aspergillosis, invasive, is related to aspergillosis and candidiasis. An important gene associated with Invasive Aspergillosis is CLEC7A (C-type lectin domain family 7, member A), and among its related pathways are TRAF Pathway and TNF Signaling. The compounds poly(i:c) and pam3csk4 have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and liver, and related mouse phenotypes are digestive/alimentary and respiratory system.

Aliases & Classifications for Invasive Aspergillosis

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9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

invasive aspergillosis 9 11
aspergillosis, invasive 63
aspergillosis invasive 46


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Disease Ontology9 DOID:0050073

Related Diseases for Invasive Aspergillosis

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18GeneCards, 19GeneDecks
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Diseases related to Invasive Aspergillosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 138)
idRelated DiseaseScoreTop Affiliating Genes
1aspergillosis32.0CD79A, MBL2, IFNG, SFTPD, TLR4
2candidiasis30.7CD79A, PLB1, IFNG
3neutropenia30.6TPMT, CXCL10, CSF3, MBL2
4leukemia30.6TLR4, HBB, TPMT, IFNG, IL17A, PLG
5acute leukemia30.5CSF3, IL17A, TPMT
6pneumonia30.4TLR4, SFTPD, CXCL10, IL17A, CSF3, MBL2
7cystic fibrosis30.3TLR4, SFTPD, HBB, IL17A, MBL2
8thyroiditis30.2MBL2, CD79A
9influenza30.2SFTPD, CXCL10, IFNG, MBL2, MBL3P, CD79A
10sepsis30.1TLR4, TLR1, SFTPD, IL17A, PLG, CSF3
11systemic lupus erythematosus30.1TLR4, TPMT, CXCL10, IFNG, IL17A, MBL2
12septic shock30.1MBL2, CSF3, TLR4
13hepatitis c30.1TLR4, CXCL10, IFNG
14arthritis29.9TLR4, HBB, CXCL10, IFNG, IL17A, PLG
15rheumatoid arthritis29.8TLR4, SFTPD, TPMT, CXCL10, IFNG, IL17A
16tuberculosis29.7TLR4, TLR1, SFTPD, HBB, CLEC7A, CXCL10
17hematopoietic stem cell transplantation10.7
18chronic granulomatous disease10.5
19acute myeloid leukemia10.5
20myeloid leukemia10.5
21hepatitis10.3
22zygomycosis10.3
23sinusitis10.3
24lupus erythematosus10.2
25lymphoblastic leukemia10.2
26non-hodgkin lymphoma10.2
27ophthalmoplegia10.2
28coccidioidomycosis10.1CLEC7A
29toxoplasmosis10.1CD79A
30q fever10.1CD79A
31bronchiolitis10.1TLR4
32allergic bronchopulmonary aspergillosis10.1SFTPD, MBL2
33acute poststreptococcal glomerulonephritis10.1CD79A
34collagen disease10.1MBL2, SFTPD
35cryptosporidiosis10.1CD79A, MBL2
36encephalitis10.1CXCL10, IL17A
37immunoglobulin g deficiency10.1CD79A, MBL2
38mesangial proliferative glomerulonephritis10.1MBL2, CD79A
39immunoglobulin alpha deficiency10.1CD79A, MBL2
40allergic contact dermatitis10.1CXCL10, IL17A
41corneal neovascularization10.1PLG, CXCL10
42membranoproliferative glomerulonephritis10.1CD79A, MBL2
43trichosporonosis10.1IFNG
44interstitial lung disease10.1SFTPD, CD79A
45bronchiectasis10.1MBL2, CD79A
46neisseria meningitidis infection10.1MBL2, TLR4
47otitis media10.1CD79A, MBL2
48conjunctivitis10.1PLG, CD79A
49bronchiolitis obliterans10.1CABIN1, IL17A, CXCL10
50graft versus host disease10.1

Graphical network of the top 20 diseases related to Invasive Aspergillosis:



Diseases related to invasive aspergillosis

Symptoms for Invasive Aspergillosis

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Drugs & Therapeutics for Invasive Aspergillosis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Invasive Aspergillosis

Drug clinical trials:

Search ClinicalTrials for Invasive Aspergillosis

Search NIH Clinical Center for Invasive Aspergillosis

Search CenterWatch for Invasive Aspergillosis

Genetic Tests for Invasive Aspergillosis

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Anatomical Context for Invasive Aspergillosis

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34MalaCards
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MalaCards organs/tissues related to Invasive Aspergillosis:

34
Lung, Testes, Liver, Myeloid, Bone, Bone marrow, Kidney, Brain, T cells, Heart, Colon, Whole blood, Breast, Thyroid, Skin, Endothelial

Animal Models for Invasive Aspergillosis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Invasive Aspergillosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.6PLG, IL17A, IFNG, CLEC7A, TLR4
2MP:00053888.0TLR4, SFTPD, HBB, CLEC7A, IFNG, IL17A
3MP:00053897.9TLR6, TLR4, HBB, TPMT, IFNG, PLG
4MP:00053677.1TLR4, HBB, IFNG, IL17A, PLG, CSF3
5MP:00107687.0TLR4, SFTPD, HBB, TPMT, CLEC7A, CXCL10
6MP:00053766.9TLR4, SFTPD, HBB, TPMT, CLEC7A, CXCL10
7MP:00053875.6CLEC7A, HBB, SFTPD, TLR1, TLR4, TLR6
8MP:00053975.4CD79A, TLR6, TLR4, TLR1, SFTPD, HBB

Publications for Invasive Aspergillosis

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53PubMed
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Articles related to Invasive Aspergillosis:

(show top 50)    (show all 503)
idTitleAuthorsYear
1
Refractory invasive aspergillosis controlled with posaconazole and pulmonary surgery in a patient with chronic granulomatous disease: case report. (24401677)
2014
2
Renal Infarction Secondary to Invasive Aspergillosis in a 5-Year-Old Girl With Acute Lymphoblastic Leukemia. (24136022)
2013
3
Comparison of a novel Aspergillus lateral-flow device and the PlateliaAr galactomannan assay for the diagnosis of invasive aspergillosis following haematopoietic stem cell transplantation. (23661288)
2013
4
TLR5 stop codon polymorphism is associated with invasive aspergillosis after allogeneic stem cell transplantation. (23862689)
2013
5
Widespread skin nodules as a manifestation of breakthrough invasive aspergillosis in a bone marrow transplant patient. (23381978)
2013
6
Characterization of specific immune responses to different Aspergillus antigens during the course of invasive Aspergillosis in hematologic patients. (24023936)
2013
7
Combined real-time PCR and galactomannan surveillance improves diagnosis of invasive aspergillosis in high risk patients with haematological malignancies. (23614624)
2013
8
Performance of serum biomarkers for the early detection of invasive aspergillosis in febrile, neutropenic patients: a multi-state model. (23799048)
2013
9
Clinical epidemiology of 960 patients with invasive aspergillosis from the PATH Alliance registry. (22898389)
2012
10
Invasive aspergillosis: an important risk factor on the short- and long-term survival of acute myeloid leukemia (AML) patients. (21909650)
2012
11
Invasive aspergillosis associated with pulmonary hydatid disease. (22824534)
2012
12
The role of combination antifungal therapy in the treatment of invasive aspergillosis: a systematic review. (22137271)
2012
13
Masaoka approach for invasive aspergillosis: an aggressive approach for an aggressive disease. (22916784)
2012
14
Invasive aspergillosis in children with acquired immunodeficiencies. (22075793)
2012
15
Epidemiology and antifungal resistance in invasive Aspergillosis according to primary disease: review of the literature. (21486729)
2011
16
Comparison of PCR-ELISA and Real-Time PCR for invasive aspergillosis diagnosis in patients with hematological malignancies. (21108574)
2011
17
Immunogenetics of invasive aspergillosis. (20840014)
2011
18
Invasive aspergillosis of orbit in immunocompetent patients: treatment and outcome. (21665281)
2011
19
Risk factors for invasive aspergillosis in acute myeloid leukemia patients prophylactically treated with posaconazole. (21314250)
2011
20
Invasive aspergillosis after pandemic (H1N1) 2009. (20507748)
2010
21
Adherence to international guidelines for the treatment of invasive aspergillosis in acute myeloid leukaemia: feasibility and utility (SEIFEM-2008B study). (20639313)
2010
22
Prophylaxis of invasive aspergillosis with voriconazole or caspofungin during building work in patients with acute leukemia. (20007135)
2010
23
Dectin-1 Y238X polymorphism associates with susceptibility to invasive aspergillosis in hematopoietic transplantation through impairment of both recipient- and donor-dependent mechanisms of antifungal immunity. (20807886)
2010
24
Impact of prior invasive aspergillosis on outcome in patients receiving reduced-intensity conditioning allogeneic hematopoietic stem cell transplant. (20629522)
2010
25
Risk stratification for invasive aspergillosis: early assessment of host susceptibility. (19253143)
2009
26
Aerosol and other novel administrations for prevention and treatment of invasive aspergillosis. (18654913)
2009
27
Invasive aspergillosis of the small bowel in an infant with acute myeloid leukemia and intestinal obstruction. (19206013)
2009
28
Invasive aspergillosis of the brain: radiologic-pathologic correlation. (19325053)
2009
29
Invasive aspergillosis in two liver transplant recipients: diagnosis by SeptiFast. (19210691)
2009
30
Diagnosis of invasive aspergillosis using bronchoalveolar lavage in haematology patients: influence of bronchoalveolar lavage human DNA content on real-time PCR performance. (18763000)
2009
31
Detection of circulating Aspergillus fumigatus DNA by real-time PCR assay of large serum volumes improves early diagnosis of invasive aspergillosis in high-risk adult patients under hematologic surveillance. (18845828)
2008
32
Invasive aspergillosis: diagnosis, prophylaxis and treatment. (18832929)
2008
33
Invasive aspergillosis in hematopoietic stem cell transplant recipients: a retrospective analysis. (19219277)
2008
34
Aortic thrombus during invasive aspergillosis in a kidney transplant recipient. (18296818)
2008
35
Molecular diagnosis of invasive aspergillosis in patients with hematologic malignancies - new answers to a diagnostic challenge? (23495815)
2008
36
Aspergillus galactomannan antigen in the bronchoalveolar lavage fluid for the diagnosis of invasive aspergillosis in lung transplant recipients. (17519782)
2007
37
Images in HIV/AIDS. Invasive aspergillosis presenting as a neck mass in a person with HIV/AIDS. (17672013)
2007
38
Invasive aspergillosis in the ICU: an emerging disease. (17646965)
2007
39
Invasive aspergillosis in chronic granulomatous disease: report of 7 cases. (16804696)
2007
40
Invasive aspergillosis of the brain: improvement with lyposomal amphoterecin B and itraconazole. (17921665)
2007
41
Disseminated invasive aspergillosis with cerebral involvement successfully treated with caspofungin and voriconazole. (17721739)
2007
42
Maintenance of therapeutic concentrations of caspofungin after temporary treatment interruption (48 hours) in a child with invasive aspergillosis. (17646422)
2007
43
Galactomannan antigen detection in the diagnosis of invasive aspergillosis. (17187481)
2007
44
Is combination antifungal therapy for invasive aspergillosis a necessity in hematopoietic stem-cell transplant recipients? (16804386)
2006
45
Hospital-wide prospective mandatory surveillance of invasive aspergillosis in a French teaching hospital (2000-2002). (16257084)
2006
46
Disseminated invasive aspergillosis. (17299570)
2006
47
Combination therapy with terbinafine and amphotericin B in a rabbit model of experimental invasive aspergillosis. (16251321)
2005
48
Efficacy of 2-(3,4-dimethyl-2,5-dihydro-1h-pyrrole-2-yl)-1-methylethyl pentanoate in a murine model of invasive aspergillosis. (16189123)
2005
49
Granulocyte transfusions in children with chronic granulomatous disease and invasive aspergillosis. (15828925)
2005
50
Comparison of galactomannan detection, PCR-enzyme-linked immunosorbent assay, and real-time PCR for diagnosis of invasive aspergillosis in a neutropenic rat model and effect of caspofungin acetate. (16275948)
2005

Variations for Invasive Aspergillosis

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Expression for genes affiliated with Invasive Aspergillosis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Invasive Aspergillosis

Search GEO for disease gene expression data for Invasive Aspergillosis.

Pathways for genes affiliated with Invasive Aspergillosis

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Sources:
51PathCards, 54QIAGEN, 58SinoBiological, 55R&D Systems, 62Tocris Bioscience, 61Thomson Reuters, 5Cell Signaling Technology, 39NCBI BioSystems Database, 31KEGG, 56Reactome
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Pathways related to Invasive Aspergillosis according to GeneCards/GeneDecks:

(show all 26)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.0TLR1, TLR6
2
Show member pathways
9.5TLR1, TLR4, TLR6
3
Show member pathways
9.5TLR1, TLR4, TLR6
49.5TLR6, TLR4, TLR1
5
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways61
Immune response IL 1 signaling pathway61
9.3TLR6, TLR4, TLR1, CLEC7A
69.3CLEC7A, TLR1, TLR4, TLR6
7
Show member pathways
IL23-mediated signaling events39
Immune response IL 10 signaling pathway61
Angiopoietin receptor Tie2-mediated signaling39
Development PDGF signaling via STATs and NF kB61
Development Angiopoietin Tie2 signaling61
9.3IFNG, IL17A, PLG
8
Show member pathways
BCR signaling pathway39
TCR Signaling Pathway39
9.3CD79A, IL17A, IFNG
99.2TLR4, CXCL10, IFNG
10
Show member pathways
thioredoxin pathway39
9.2PLG, IFNG, HBB
119.2TLR4, IFNG, IL17A
12
Show member pathways
9.2TLR4, IFNG, IL17A
139.1CSF3, IFNG
149.1TLR6, TLR4, SFTPD, CLEC7A, MBL2
159.0IFNG, TLR1, TLR4, TLR6
16
Show member pathways
8.9PLG, IFNG, CXCL10, TLR4
17
Show member pathways
8.9CSF3, IL17A, TLR4
188.8TLR6, TLR4, TLR1, CLEC7A, IFNG
19
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
8.8TLR6, TLR4, TLR1, CXCL10, IFNG
20
Show member pathways
8.7TLR6, TLR4, TLR1, IFNG, IL17A
21
Show member pathways
IL27-mediated signaling events39
8.7TLR6, TLR4, TLR1, IFNG, IL17A
22
Show member pathways
8.7TLR6, TLR4, TLR1, IFNG, CD79A
23
Show member pathways
Transcription NF kB signaling pathway61
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response61
8.5IFNG, CXCL10, SFTPD, TLR1, TLR4, TLR6
24
Show member pathways
8.5TLR6, TLR4, TLR1, CXCL10, CSF3
258.3CSF3, IFNG, HBB, TLR4
26
Show member pathways
8.1TLR4, CXCL10, IFNG, IL17A, CSF3

Compounds for genes affiliated with Invasive Aspergillosis

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Sources:
62Tocris Bioscience, 46Novoseek, 30IUPHAR, 12DrugBank, 3BitterDB, 52PharmGKB, 25HMDB
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Compounds related to Invasive Aspergillosis according to GeneCards/GeneDecks:

(show top 50)    (show all 82)
idCompoundScoreTop Affiliating Genes
1poly(i:c)6210.0TLR1, TLR4, TLR6
2pam3csk4629.9TLR1, TLR4, TLR6
3pam2csk4629.9TLR6, TLR1, TLR4
4resiquimod46 6210.9TLR6, TLR4, TLR1
5flagellin46 3010.8TLR6, TLR1, TLR4
6zymosan469.8CLEC7A, MBL2, TLR4
7lipoteichoic acid469.7MBL2, TLR1, TLR4
8peptidoglycan46 3010.7TLR4, TLR1, TLR6, MBL2
9tuberculin469.7IFNG, MBL2, CD79A
10con a469.6IFNG, MBL2, CD79A
111-methyltryptophan469.6IFNG, TLR4
12polymyxin b469.5TLR4, IFNG, MBL2
13imiquimod46 62 30 1212.4TLR6, TLR4, TLR1, IFNG
14polyinosinic-polycytidylic acid469.4TLR4, IFNG, CXCL10
15azathioprine46 3 52 1212.4CABIN1, TPMT, HBB, CD79A
162,5-oligoadenylate469.4IFNG, CXCL10, TLR4
17neopterin469.4CXCL10, IFNG, MBL2, CD79A
18poly(i-c)469.3TLR4, IFNG, CXCL10
19infliximab46 52 1211.3IL17A, IFNG, CXCL10, TLR4
20ifn-alpha469.3TLR4, CXCL10, IL17A, IFNG
21il 10469.1TLR4, CXCL10, IFNG
22creatinine469.1TPMT, CD79A, MBL2, CXCL10, IL17A
23allergens469.1TLR4, SFTPD, CXCL10, IFNG, CD79A
24ribavirin46 52 1211.0IFNG, CXCL10, MBL2, CSF3
25polysaccharide468.9SFTPD, MBL2, MBL3P, CD79A, TLR4
26pge2468.8CD79A, IL17A, IFNG, CXCL10, TLR4
27ccl346 309.8CSF3, TLR4, CXCL10, IFNG
28histamine46 30 2510.8SFTPD, TPMT, CXCL10, IFNG, CD79A, TLR4
29mannan468.7TLR4, MBL2, CD79A, MBL3P, IL17A, SFTPD
30mycophenolate mofetil46 52 1210.6CSF3, TPMT, CABIN1, CD79A, IFNG
31methotrexate52 46 1210.6TLR4, IL17A, CSF3, CD79A, TPMT
32glucose468.5TLR4, CLEC7A, CXCL10, PLG, SFTPD, MBL2
33lipid468.5TLR4, TLR6, MBL2, TLR1, PLG, SFTPD
34mannose468.5TLR4, CD79A, MBL3P, MBL2, IL17A, CLEC7A
35prednisolone46 30 1210.4SFTPD, TPMT, IFNG, CSF3, MBL2, CD79A
36tacrolimus46 52 1210.4TPMT, IFNG, CD79A, TLR4, CABIN1, IL17A
37steroid468.4PLG, SFTPD, HBB, TPMT, IL17A, CABIN1
38endotoxin468.3TLR4, SFTPD, IL17A, CXCL10, IFNG, CSF3
39anti-fungal468.3CD79A, MBL2, IFNG, SFTPD, TLR4, CSF3
40cysteine468.2IFNG, HBB, MBL2, CD79A, SFTPD, TLR4
41atp46 309.2HBB, PLG, TPMT, CXCL10, MBL2, TLR4
42rantes468.0MBL2, IL17A, CSF3, IFNG, CXCL10, TLR6
43cycloheximide468.0TLR4, CXCL10, CSF3, IFNG, HBB
44thymidine46 259.0IFNG, SFTPD, CSF3, HBB, CXCL10, IL17A
45cyclosporin a46 30 629.8TPMT, TLR4, IL17A, CSF3, CABIN1, CD79A
46nitric oxide46 25 129.8MBL2, TLR4, SFTPD, HBB, CXCL10, IL17A
47calcium46 52 25 1210.7PLB1, TLR4, SFTPD, HBB, CXCL10, MBL2
48vegf467.5CSF3, CD79A, PLG, CXCL10, IFNG, TLR4
49tyrosine467.5CLEC7A, IL17A, CSF3, TLR4, HBB, MBL2
50dexamethasone46 52 30 1210.5MBL2, IL17A, IFNG, CXCL10, TLR4, CLEC7A

GO Terms for genes affiliated with Invasive Aspergillosis

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Sources:
17Gene Ontology
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Cellular components related to Invasive Aspergillosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.5MBL2, PLG, IFNG, CXCL10, HBB, SFTPD
2external side of plasma membraneGO:0098978.2CD79A, IL17A, IFNG, CXCL10, CLEC7A, TLR4
3extracellular spaceGO:0056157.4SFTPD, CXCL10, IFNG, IL17A, PLG, CSF3

Biological processes related to Invasive Aspergillosis according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1detection of triacyl bacterial lipopeptideGO:04249510.3TLR1, TLR6
2positive regulation of phagocytosisGO:05076610.1MBL2, CLEC7A, SFTPD
3macrophage activationGO:04211610.0TLR4, TLR1
4positive regulation of tumor necrosis factor biosynthetic processGO:04253510.0TLR4, TLR1
5T-helper 1 type immune responseGO:0420889.9TLR4, TLR6
6positive regulation of interleukin-23 productionGO:0327479.9IFNG, IL17A
7positive regulation of interleukin-6 biosynthetic processGO:0454109.8IFNG, TLR1, TLR6
8negative regulation of growth of symbiont in hostGO:0441309.8MBL2, IFNG
9positive regulation of MHC class II biosynthetic processGO:0453489.8TLR4, IFNG
10positive regulation of interleukin-12 biosynthetic processGO:0450849.8TLR4, IFNG
11defense response to protozoanGO:0428329.7CLEC7A, IFNG
12negative regulation of interleukin-17 productionGO:0327009.7TLR4, IFNG
13toll-like receptor signaling pathwayGO:0022249.7TLR1, TLR4, TLR6
14positive regulation of tumor necrosis factor productionGO:0327609.6TLR4, CLEC7A, IFNG
15inflammatory responseGO:0069549.5TLR6, TLR1, CLEC7A, CXCL10, IL17A
16positive regulation of osteoclast differentiationGO:0456729.5IL17A, IFNG
17positive regulation of interleukin-12 productionGO:0327359.5IFNG, TLR4
18positive regulation of nitric oxide biosynthetic processGO:0454299.4IFNG, HBB, TLR4
19innate immune responseGO:0450879.2TLR6, TLR4, TLR1, SFTPD, CLEC7A, MBL2
20defense response to bacteriumGO:0427429.2MBL2, IFNG, SFTPD, TLR4, TLR6
21cell surface receptor signaling pathwayGO:0071669.1CABIN1, IFNG, CXCL10
22cellular response to lipopolysaccharideGO:0712229.0CSF3, IFNG, TLR4
23immune responseGO:0069558.5TLR6, TLR4, TLR1, CXCL10, IL17A, CSF3
24positive regulation of transcription from RNA polymerase II promoterGO:0459448.3CSF3, IL17A, IFNG, CXCL10, TLR4

Molecular functions related to Invasive Aspergillosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane signaling receptor activityGO:0048888.9CD79A, TLR1, TLR4, TLR6
2cytokine activityGO:0051258.8CSF3, IL17A, IFNG

Products for genes affiliated with Invasive Aspergillosis

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  • Antibodies
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Sources for Invasive Aspergillosis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet