MCID: INV001
MIFTS: 47

Invasive Aspergillosis malady

Summaries for Invasive Aspergillosis

Sources:
8Disease Ontology, 33MalaCards
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Disease Ontology:8 An aspergillosis that is a serious fungal infection of the lung with pneumonia caused by aspergillus, which spreads to other parts of the body through bloodstream in patients with acute leukemia and recipients of tissue transplants. clinical symptoms include pulmonary nodules and hemorrhage.

MalaCards: Invasive Aspergillosis, also known as aspergillosis, invasive, is related to aspergillosis and acute leukemia. An important gene associated with Invasive Aspergillosis is CLEC7A (C-type lectin domain family 7, member A), and among its related pathways are Th17 Differentiation and Immune response Bacterial infections in normal airways. The compounds endotoxin and glucose have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and brain, and related mouse phenotypes are renal/urinary system and homeostasis/metabolism.

Aliases & Classifications for Invasive Aspergillosis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS
See all sources

Aliases & Descriptions:

invasive aspergillosis 8 10
aspergillosis, invasive 61
aspergillosis invasive 45


External Ids:

Disease Ontology8 DOID:0050073

Related Diseases for Invasive Aspergillosis

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Invasive Aspergillosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 155)
idRelated DiseaseScoreTop Affiliating Genes
1aspergillosis32.1CD79A, MBL2, SFTPD, TLR4
2acute leukemia30.9CSF3, IL17A, TPMT
3pulmonary disease, chronic obstructive30.4IL17A, CXCL10, SFTPD
4cystic fibrosis30.3TLR4, SFTPD, MBL2, HBB, IL17A
5systemic lupus erythematosus30.2TLR4, MBL2, CD79A, CXCL10, IL17A, TPMT
6sepsis30.2TLR4, TLR1, SFTPD, MBL2, CSF3, IL17A
7sinusitis30.0CD79A
8amyloidosis30.0CD79A
9hepatitis c30.0TLR4, CXCL10
10thyroiditis30.0MBL2, CD79A
11adenocarcinoma30.0SFTPD, CXCL10, PLG
12septic shock30.0TLR4, MBL2, CSF3
13arthritis30.0TLR4, HBB, CXCL10, IL17A, PLG
14tuberculosis30.0TLR4, TLR1, SFTPD, MBL2, CD79A, HBB
15hematopoietic stem cell transplantation10.6
16invasive mole10.6
17chronic granulomatous disease10.5
18acute myeloid leukemia10.5
19zygomycosis10.3
20hepatitis a10.2
21influenza, severe10.2
22graft versus host disease10.0
23acute thyroiditis10.0
24pearson syndrome10.0
25acute pancreatitis10.0
26antiphospholipid syndrome10.0
27multidrug-resistant tuberculosis10.0
28toxic megacolon10.0
29dengue shock syndrome10.0
30pulmonary aspergilloma10.0
31cushing's syndrome10.0
32carotid artery thrombosis10.0
33acute t cell leukemia10.0
34melas syndrome10.0
35autoimmune hemolytic anemia10.0
36autoimmune hepatitis10.0
37hepatitis d10.0
38pyoderma gangrenosum10.0
39temporal arteritis10.0
40alcoholic hepatitis10.0
41aortic aneurysm10.0
42aplastic anemia10.0
43autosomal recessive disease10.0
44t-cell leukemia10.0
45catastrophic antiphospholipid syndrome10.0
46tracheoesophageal fistula10.0
47swyer syndrome10.0
48toxic epidermal necrolysis10.0
49mycetoma10.0
50swyer-james syndrome10.0

Graphical network of the top 20 diseases related to Invasive Aspergillosis:



Diseases related to invasive aspergillosis

Clinical Features for Invasive Aspergillosis

Drugs & Therapeutics for Invasive Aspergillosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Invasive Aspergillosis

Drug clinical trials:

Search ClinicalTrials for Invasive Aspergillosis

Search NIH Clinical Center for Invasive Aspergillosis

Search CenterWatch for Invasive Aspergillosis

Genetic Tests for Invasive Aspergillosis

Anatomical Context for Invasive Aspergillosis

Sources:
33MalaCards
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MalaCards organs/tissues related to Invasive Aspergillosis:

33
Skin, Liver, Brain, Kidney, Lung, Bone marrow, Whole blood, Heart, Small intestine, Colon, Thyroid, Breast, Myeloid, Monocytes, Nk cells, T cells, B lymphoblasts, B cells, Endothelial, Temporal lobe

Animal Models for Invasive Aspergillosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Invasive Aspergillosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.4TLR4, HBB, IL17A, PLG
2MP:00053768.2SFTPD, MBL2, CD79A, HBB, CLEC7A, CXCL10
3MP:00053977.8TLR4, SFTPD, MBL2, CSF3, CD79A, HBB
4MP:00053877.2PLG, CABIN1, TLR4, TLR6, TLR1, SFTPD

Publications for Invasive Aspergillosis

Sources:
51PubMed
See all sources

Articles related to Invasive Aspergillosis:

(show top 50)    (show all 638)
idTitleAuthorsYear
1
Initial voriconazole trough blood levels and clinical outcomes of invasive aspergillosis in patients with hematologic malignancies. (22712456)
2013
2
Interlaboratory and interstudy reproducibility of a novel lateral-flow device and influence of antifungal therapy on detection of invasive pulmonary aspergillosis. (23175252)
2013
3
Population pharmacokinetics of escalating doses of caspofungin in a phase II study of patients with invasive aspergillosis. (23335740)
2013
4
Retrospective assessment of secondary prophylaxis for invasive aspergillosis in neutropenic hematology patients and identification of risk factors for relapse of fungal disease. (23565772)
2013
5
Interleukin-12 and interleukin-2 alone or in combination against the infection in invasive pulmonary aspergillosis mouse model. (22834482)
2013
6
Evaluation of MycAssaya8c Aspergillus for diagnosis of invasive pulmonary aspergillosis in patients without hematological cancer. (23620764)
2013
7
Successful pneumonectomy for invasive pulmonary aspergillosis and advanced non-small cell-lung cancer. (23505081)
2013
8
Utility of bronchoalveolar lavage fluid galactomannan alone or in combination with PCR for the diagnosis of invasive aspergillosis in adult hematology patients: A systematic review and meta-analysis. (23799871)
2013
9
Screening with serum galactomannan might be associated with better outcome than symptom-triggered galactomannan testing in allogeneic HSCT recipients with invasive aspergillosis. (24046295)
2013
10
Clinical epidemiology of 960 patients with invasive aspergillosis from the PATH Alliance registry. (22898389)
2012
11
Detection of invasive pulmonary aspergillosis in haematological malignancy patients by using lateral-flow technology. (22473419)
2012
12
Invasive aspergillosis involving the lungs and brain after short period of steroid injection: a case report. (23101010)
2012
13
Fulminant invasive aspergillosis of the mediastinum in an immunocompetent host: a case report. (22989346)
2012
14
Overtreating or underdiagnosing invasive pulmonary aspergillosis (IPA) in critically ill H1N1 patients: who is right? (22895827)
2012
15
A novel extraction method combining plasma with a whole-blood fraction shows excellent sensitivity and reproducibility for patients at high risk for invasive aspergillosis. (22593600)
2012
16
In vivo and in situ imaging of experimental invasive pulmonary aspergillosis using fibered confocal fluorescence microscopy. (22004362)
2012
17
Impact of galactomannan testing on the prevalence of invasive aspergillosis in patients with hematological malignancies. (21905944)
2012
18
Seven-year surveillance of nosocomial invasive aspergillosis in a French University Hospital. (22902944)
2012
19
What should be the optimal cut-off of serum 1,3-I^-D-glucan for the detection of invasive pulmonary aspergillosis in patients with haematological malignancies? (22188426)
2012
20
Invasive pulmonary aspergillosis is a frequent complication of critically ill H1N1 patients: a retrospective study. (22895826)
2012
21
Dectin-1 and DC-SIGN polymorphisms associated with invasive pulmonary Aspergillosis infection. (22384201)
2012
22
Pathogen-specific DNA enrichment does not increase sensitivity of PCR for diagnosis of invasive aspergillosis in neutropenic patients. (21191054)
2011
23
Invasive rhino-orbital aspergillosis. (23024936)
2011
24
Diagnosis of invasive aspergillosis by a commercial real-time PCR assay for Aspergillus DNA in bronchoalveolar lavage fluid samples from high-risk patients compared to a galactomannan enzyme immunoassay. (22012015)
2011
25
Invasive aspergillosis osteomyelitis in children--a case report and review of the literature. (20512571)
2010
26
What makes Aspergillus fumigatus a successful pathogen? Genes and molecules involved in invasive aspergillosis. (20974273)
2010
27
High rate of breakthrough invasive aspergillosis among patients receiving caspofungin for persistent fever and neutropenia. (19735276)
2010
28
Chest computed tomography versus serum galactomannan enzyme immunoassay for the diagnosis of probable invasive aspergillosis: to be decided. (21034201)
2010
29
Development of an HPTLC-based diagnostic method for invasive aspergillosis. (20033890)
2010
30
Risk stratification for invasive aspergillosis: early assessment of host susceptibility. (19253143)
2009
31
Predicting survival in adults with invasive aspergillosis during therapy for hematological malignancies or after hematopoietic stem cell transplantation: Single-center analysis and validation of the Seattle, French, and Strasbourg prognostic indexes. (19676118)
2009
32
Value of serial quantification of fungal DNA by a real-time PCR-based technique for early diagnosis of invasive Aspergillosis in patients with febrile neutropenia. (19109479)
2009
33
Successful treatment of ascending aortic graft and valve endocarditis after debulking splenectomy for invasive aspergillosis and mucor. (19999923)
2009
34
A case of invasive aspergillosis in a patient with no identifiable immunodeficiencies. (21516164)
2008
35
Multidrug resistant tuberculosis co-existing with aspergilloma and invasive aspergillosis in a 50 year old diabetic woman: a case report. (18992166)
2008
36
Invasive aspergillosis in paediatric oncology patients. (19803305)
2008
37
Comparison of the use of administrative data and an active system for surveillance of invasive aspergillosis . (18171183)
2008
38
Invasive aspergillosis in chronic granulomatous disease: report of 7 cases. (16804696)
2007
39
Maintenance of therapeutic concentrations of caspofungin after temporary treatment interruption (48 hours) in a child with invasive aspergillosis. (17646422)
2007
40
Potential of lung surfactant proteins, SP-A and SP-D, and mannan binding lectin for therapy and genetic predisposition to allergic and invasive aspergillosis. (19075981)
2007
41
Invasive aspergillosis: epidemiology, diagnosis and management in immunocompromised patients. (17661528)
2007
42
Serum Aspergillus galactomannan antigen values strongly correlate with outcome of invasive aspergillosis: a study of 56 patients with hematologic cancer. (17607669)
2007
43
Effects of Aspergillus fumigatus gliotoxin and methylprednisolone on human neutrophils: implications for the pathogenesis of invasive aspergillosis. (17626149)
2007
44
Hospital-wide prospective mandatory surveillance of invasive aspergillosis in a French teaching hospital (2000-2002). (16257084)
2006
45
Disseminated invasive aspergillosis. (17299570)
2006
46
Molecular diagnosis of invasive aspergillosis: the long and winding road. (17661641)
2006
47
Comparison of galactomannan detection, PCR-enzyme-linked immunosorbent assay, and real-time PCR for diagnosis of invasive aspergillosis in a neutropenic rat model and effect of caspofungin acetate. (16275948)
2005
48
Prospects of vaccines for invasive aspergillosis. (16396243)
2005
49
Cavernous sinus thrombosis secondary to non-invasive sphenoid aspergillosis. (16008074)
2005
50
Lack of vessel wall elastolysis in human invasive pulmonary aspergillosis. (1452348)
1992

Genetic Variations for Invasive Aspergillosis

Expression for genes affiliated with Invasive Aspergillosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Invasive Aspergillosis

Search GEO for disease gene expression data for Invasive Aspergillosis.

Pathways for genes affiliated with Invasive Aspergillosis

Sources:
53R&D Systems, 54Reactome, 52QIAGEN, 60Tocris Bioscience, 4Cell Signaling Technology, 30KEGG, 12EMD Millipore, 38NCBI BioSystems Database
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Pathways related to Invasive Aspergillosis according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.1TLR6, TLR1
2
Immune response Bacterial infections in normal airways
9.8SFTPD, TLR1, TLR4
3
Hide members
9.8TLR1, TLR6, TLR4
49.8TLR4, TLR6, TLR1
59.8TLR4, TLR6, TLR1
69.6CLEC7A, TLR1, TLR6, TLR4
79.6TLR4, TLR6, TLR1, CLEC7A
8
Hide members
9.6TLR4, TLR6, TLR1, CLEC7A
99.6CXCL10, TLR1, TLR6, TLR4
10
Hide members
9.6CXCL10, TLR1, TLR6, TLR4
11
Hide members
9.6TLR4, TLR6, TLR1, IL17A
12
Hide members
9.5CD79A, TLR1, TLR6, TLR4
13
Cytokine production by Th17 cells in CF (Mouse model)
9.4IL17A, CSF3, TLR4
149.4CLEC7A, MBL2, SFTPD, TLR6, TLR4
159.4HBB, CSF3, TLR4
16
Hide members
9.1TLR4, TLR6, TLR1, CSF3, CXCL10

Compounds for genes affiliated with Invasive Aspergillosis

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 50PharmGKB, 2BitterDB, 24HMDB
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Compounds related to Invasive Aspergillosis according to GeneCards/GeneDecks:

(show all 48)
idCompoundScoreTop Affiliating Genes
1endotoxin4510.4CSF3
2glucose4510.3CLEC7A, SFTPD
3pam2csk46010.2TLR4, TLR6, TLR1
4pam3csk46010.2TLR4, TLR6, TLR1
5poly(i:c)6010.2TLR4, TLR6, TLR1
6resiquimod45 6011.2TLR4, TLR6, TLR1
7zymosan4510.2TLR4, MBL2, CLEC7A
8flagellin45 2911.2TLR1, TLR6, TLR4
9imiquimod45 29 60 1113.2TLR1, TLR6, TLR4
10lipoteichoic acid4510.1TLR4, TLR1, MBL2
11infliximab45 50 1112.0IL17A, CXCL10, TLR4
12prednisolone45 29 1112.0SFTPD, MBL2, CD79A, TPMT
13peptidoglycan45 2911.0MBL2, TLR1, TLR6, TLR4
14neopterin4510.0CXCL10, CD79A, MBL2
15ifn-alpha4510.0IL17A, CXCL10, TLR4
16tuberculin4510.0CD79A, MBL2
17n-acetylglucosamine4510.0MBL2, MBL3P, SFTPD
18dexamethasone45 50 29 1113.0TLR4, SFTPD, CD79A, CLEC7A
19pneumococcal4510.0CD79A, TLR4
20allergens459.9TLR4, SFTPD, CD79A, CXCL10
21chloroquine45 2 50 29 1113.8TLR4, CD79A, CXCL10
22ribavirin45 50 1111.8MBL2, CSF3, CXCL10
23azathioprine45 50 2 1112.8CABIN1, CD79A, HBB, TPMT
24ccl345 2910.7TLR4, CSF3, CXCL10
25rantes459.7TLR4, MBL2, CSF3, IL17A
26histamine45 29 2411.6TLR4, SFTPD, CD79A, CXCL10, TPMT
27suramin45 29 1111.6PLG, CXCL10, CD79A
28mycophenolate mofetil45 50 1111.6TPMT, CD79A, CSF3, CABIN1
29vitamin d459.6TLR4, MBL2, CD79A, CXCL10
30estrogen459.6MBL2, SSBP3, CD79A
31creatinine459.6MBL2, CD79A, CXCL10, IL17A, TPMT
32polysaccharide459.5TLR4, SFTPD, MBL3P, MBL2, CD79A
33methotrexate45 50 1111.5TPMT, IL17A, CD79A, CSF3
34fibrinogen459.5TLR4, MBL2, CD79A, PLG
35anti-fungal459.4TLR4, SFTPD, MBL2, CSF3, CD79A
36tacrolimus45 50 1111.4CABIN1, TLR4, CD79A, CXCL10, IL17A, TPMT
37mannan459.4IL17A, CD79A, MBL2, MBL3P, SFTPD, TLR4
38mannose459.2TLR4, SFTPD, MBL3P, MBL2, CD79A, CLEC7A
39thymidine45 2410.2SFTPD, CSF3, HBB, CXCL10, IL17A, PLG
40lipid459.1TLR4, TLR6, TLR1, SFTPD, MBL2, CXCL10
41cyclosporin a45 29 6011.1CABIN1, TLR4, CSF3, CD79A, IL17A, TPMT
42steroid459.0CABIN1, SFTPD, MBL2, CD79A, HBB, IL17A
43nitric oxide45 11 2411.0CABIN1, TLR4, SFTPD, MBL2, HBB, CXCL10
44vegf458.9TLR4, MBL2, CSF3, CD79A, CXCL10, IL17A
45atp45 299.8TLR4, MBL2, SSBP3, HBB, CXCL10, PLG
46cysteine458.7TLR4, SFTPD, MBL2, SSBP3, CD79A, HBB
47tyrosine458.5TLR4, MBL2, CSF3, HBB, CLEC7A, CXCL10
48serine458.5TLR4, MBL3P, SSBP3, HBB, PLG

GO Terms for genes affiliated with Invasive Aspergillosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Invasive Aspergillosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.0IL17A, CXCL10, CLEC7A, CD79A, TLR4
2extracellular spaceGO:0056158.9MBL2, CSF3, CXCL10, IL17A, PLG, SFTPD

Biological processes related to Invasive Aspergillosis according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1toll-like receptor 6 signaling pathwayGO:03415010.3TLR1, TLR6
2detection of diacyl bacterial lipopeptideGO:04249610.2TLR1, TLR6
3positive regulation of interleukin-6 biosynthetic processGO:04541010.2TLR6, TLR1
4positive regulation of phagocytosisGO:05076610.1CLEC7A, MBL2, SFTPD
5regulation of cytokine secretionGO:05070710.1TLR1, TLR6, TLR4
6T-helper 1 type immune responseGO:04208810.0TLR4, TLR6, TLR1
7macrophage activationGO:04211610.0TLR1, TLR4
8defense response to bacteriumGO:0427429.8MBL2, TLR6, TLR4
9positive regulation of tumor necrosis factor biosynthetic processGO:0425359.7TLR1, TLR4
10MyD88-dependent toll-like receptor signaling pathwayGO:0027559.7TLR4, TLR6, TLR1
11inflammatory responseGO:0069549.6TLR6, TLR1, CLEC7A, CXCL10, IL17A
12innate immune responseGO:0450879.4TLR4, TLR6, TLR1, SFTPD, MBL2, CLEC7A
13immune responseGO:0069559.1TLR4, TLR6, TLR1, CSF3, CXCL10, IL17A

Molecular functions related to Invasive Aspergillosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane signaling receptor activityGO:0048889.5CD79A, TLR1, TLR6, TLR4

Products for genes affiliated with Invasive Aspergillosis

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Sources for Invasive Aspergillosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet