Aliases & Classifications for Invasive Aspergillosis

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS
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Invasive Aspergillosis, Aliases & Descriptions:

Name: Invasive Aspergillosis 9 11
Aspergillosis, Invasive 60
 
Aspergillosis Invasive 43


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Disease Ontology9 DOID:0050073

Summaries for Invasive Aspergillosis

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Disease Ontology:9 An aspergillosis that is a serious fungal infection of the lung with pneumonia caused by aspergillus, which spreads to other parts of the body through bloodstream in patients with acute leukemia and recipients of tissue transplants. clinical symptoms include pulmonary nodules and hemorrhage.

MalaCards based summary: Invasive Aspergillosis, also known as aspergillosis, invasive, is related to aspergillosis and neutropenia. An important gene associated with Invasive Aspergillosis is CLEC7A (C-type lectin domain family 7, member A), and among its related pathways are TRAF Pathway and TNF Signaling. The compounds poly(i:c) and pam3csk4 have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and liver, and related mouse phenotypes are digestive/alimentary and respiratory system.

Related Diseases for Invasive Aspergillosis

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Diseases related to Invasive Aspergillosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 133)
idRelated DiseaseScoreTop Affiliating Genes
1aspergillosis31.7CD79A, MBL2, IFNG, SFTPD, TLR4
2neutropenia30.7TPMT, CXCL10, CSF3, MBL2
3thyroiditis30.7MBL2, CD79A
4candidiasis30.6CD79A, PLB1, IFNG
5acute leukemia30.4CSF3, IL17A, TPMT
6liver disease30.2TLR4, CABIN1, CD79A
7acute respiratory distress syndrome30.2PLG, SFTPD
8cystic fibrosis30.1TLR4, SFTPD, HBB, IL17A, MBL2
9acute graft versus host disease30.0IFNG, CSF3
10colitis30.0IL17A, IFNG, CXCL10, TLR4
11hepatitis c30.0TLR4, CXCL10, IFNG
12pneumonia29.9TLR4, SFTPD, CXCL10, IL17A, CSF3, MBL2
13influenza29.9SFTPD, CXCL10, IFNG, MBL2, MBL3P, CD79A
14systemic lupus erythematosus29.4TLR4, TPMT, CXCL10, IFNG, IL17A, MBL2
15ulcerative colitis29.4TLR4, TPMT, CXCL10, IFNG, IL17A, CD79A
16leukemia29.3TLR4, HBB, TPMT, IFNG, IL17A, PLG
17arthritis29.3TLR4, HBB, CXCL10, IFNG, IL17A, PLG
18rheumatoid arthritis28.8TLR4, SFTPD, TPMT, CXCL10, IFNG, IL17A
19tuberculosis28.6TLR4, TLR1, SFTPD, HBB, CLEC7A, CXCL10
20hematopoietic stem cell transplantation10.8
21coccidioidomycosis10.6CLEC7A
22chronic granulomatous disease10.5
23myeloid leukemia10.5
24toxoplasmosis10.5CD79A
25q fever10.5CD79A
26bronchiolitis10.4TLR4
27allergic bronchopulmonary aspergillosis10.4SFTPD, MBL2
28acute poststreptococcal glomerulonephritis10.4CD79A
29collagen disease10.4MBL2, SFTPD
30cryptosporidiosis10.4CD79A, MBL2
31encephalitis10.4CXCL10, IL17A
32immunoglobulin g deficiency10.4CD79A, MBL2
33mesangial proliferative glomerulonephritis10.3MBL2, CD79A
34immunoglobulin alpha deficiency10.3CD79A, MBL2
35allergic contact dermatitis10.3CXCL10, IL17A
36corneal neovascularization10.3PLG, CXCL10
37membranoproliferative glomerulonephritis10.3CD79A, MBL2
38hepatitis10.3
39sinusitis10.3
40zygomycosis10.3
41interstitial lung disease10.3SFTPD, CD79A
42trichosporonosis10.3IFNG
43bronchiectasis10.3MBL2, CD79A
44neisseria meningitidis infection10.3MBL2, TLR4
45otitis media10.3CD79A, MBL2
46conjunctivitis10.3PLG, CD79A
47common variable immunodeficiency10.3CD79A, MBL2
48bronchiolitis obliterans10.3CABIN1, IL17A, CXCL10
49pulmonary disease, chronic obstructive10.2SFTPD, CXCL10, IL17A
50meningitis10.2CXCL10, MBL2, CD79A

Graphical network of the top 20 diseases related to Invasive Aspergillosis:



Diseases related to invasive aspergillosis

Symptoms for Invasive Aspergillosis

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Drugs & Therapeutics for Invasive Aspergillosis

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Drug clinical trials:

Search ClinicalTrials for Invasive Aspergillosis

Search NIH Clinical Center for Invasive Aspergillosis

Genetic Tests for Invasive Aspergillosis

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Anatomical Context for Invasive Aspergillosis

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MalaCards organs/tissues related to Invasive Aspergillosis:

31
Lung, Testes, Liver, Myeloid, Bone, Bone marrow, Kidney, Brain, T cells, Neutrophil, Whole blood, Heart, Colon, Thyroid, Breast, Skin, Endothelial

Animal Models for Invasive Aspergillosis or affiliated genes

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MGI Mouse Phenotypes related to Invasive Aspergillosis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.6PLG, IL17A, IFNG, CLEC7A, TLR4
2MP:00053888.0TLR4, SFTPD, HBB, CLEC7A, IFNG, IL17A
3MP:00053897.9TLR6, TLR4, HBB, TPMT, IFNG, PLG
4MP:00053677.1TLR4, HBB, IFNG, IL17A, PLG, CSF3
5MP:00107687.0TLR4, SFTPD, HBB, TPMT, CLEC7A, CXCL10
6MP:00053766.9TLR4, SFTPD, HBB, TPMT, CLEC7A, CXCL10
7MP:00053875.6CLEC7A, HBB, SFTPD, TLR1, TLR4, TLR6
8MP:00053975.4CD79A, TLR6, TLR4, TLR1, SFTPD, HBB

Publications for Invasive Aspergillosis

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Articles related to Invasive Aspergillosis:

(show top 50)    (show all 544)
idTitleAuthorsYear
1
Genomic analysis for single nucleotide polymorphisms (Asp299Gly and Thr399lle) in Japanese patients with invasive aspergillosis. (25766605)
2015
2
PCR in diagnosis of invasive aspergillosis: a meta-analysis of diagnostic performance. (25122854)
2014
3
Serum Galactomannan-Based Early Detection of Invasive Aspergillosis in Hematology Patients Receiving Effective Antimold Prophylaxis. (25165088)
2014
4
Refractory invasive aspergillosis controlled with posaconazole and pulmonary surgery in a patient with chronic granulomatous disease: case report. (24401677)
2014
5
Renal Infarction Secondary to Invasive Aspergillosis in a 5-Year-Old Girl With Acute Lymphoblastic Leukemia. (24136022)
2013
6
Comparison of a novel Aspergillus lateral-flow device and the PlateliaAr galactomannan assay for the diagnosis of invasive aspergillosis following haematopoietic stem cell transplantation. (23661288)
2013
7
TLR5 stop codon polymorphism is associated with invasive aspergillosis after allogeneic stem cell transplantation. (23862689)
2013
8
Widespread skin nodules as a manifestation of breakthrough invasive aspergillosis in a bone marrow transplant patient. (23381978)
2013
9
Characterization of specific immune responses to different Aspergillus antigens during the course of invasive Aspergillosis in hematologic patients. (24023936)
2013
10
Combined real-time PCR and galactomannan surveillance improves diagnosis of invasive aspergillosis in high risk patients with haematological malignancies. (23614624)
2013
11
Performance of serum biomarkers for the early detection of invasive aspergillosis in febrile, neutropenic patients: a multi-state model. (23799048)
2013
12
Clinical epidemiology of 960 patients with invasive aspergillosis from the PATH Alliance registry. (22898389)
2012
13
Invasive aspergillosis: an important risk factor on the short- and long-term survival of acute myeloid leukemia (AML) patients. (21909650)
2012
14
Invasive aspergillosis associated with pulmonary hydatid disease. (22824534)
2012
15
The role of combination antifungal therapy in the treatment of invasive aspergillosis: a systematic review. (22137271)
2012
16
Masaoka approach for invasive aspergillosis: an aggressive approach for an aggressive disease. (22916784)
2012
17
Invasive aspergillosis in children with acquired immunodeficiencies. (22075793)
2012
18
Epidemiology and antifungal resistance in invasive Aspergillosis according to primary disease: review of the literature. (21486729)
2011
19
Comparison of PCR-ELISA and Real-Time PCR for invasive aspergillosis diagnosis in patients with hematological malignancies. (21108574)
2011
20
Immunogenetics of invasive aspergillosis. (20840014)
2011
21
Invasive aspergillosis of orbit in immunocompetent patients: treatment and outcome. (21665281)
2011
22
Risk factors for invasive aspergillosis in acute myeloid leukemia patients prophylactically treated with posaconazole. (21314250)
2011
23
Invasive aspergillosis after pandemic (H1N1) 2009. (20507748)
2010
24
Adherence to international guidelines for the treatment of invasive aspergillosis in acute myeloid leukaemia: feasibility and utility (SEIFEM-2008B study). (20639313)
2010
25
Prophylaxis of invasive aspergillosis with voriconazole or caspofungin during building work in patients with acute leukemia. (20007135)
2010
26
Dectin-1 Y238X polymorphism associates with susceptibility to invasive aspergillosis in hematopoietic transplantation through impairment of both recipient- and donor-dependent mechanisms of antifungal immunity. (20807886)
2010
27
Risk stratification for invasive aspergillosis: early assessment of host susceptibility. (19253143)
2009
28
Aerosol and other novel administrations for prevention and treatment of invasive aspergillosis. (18654913)
2009
29
Invasive aspergillosis of the small bowel in an infant with acute myeloid leukemia and intestinal obstruction. (19206013)
2009
30
Invasive aspergillosis of the brain: radiologic-pathologic correlation. (19325053)
2009
31
Invasive aspergillosis in two liver transplant recipients: diagnosis by SeptiFast. (19210691)
2009
32
Diagnosis of invasive aspergillosis using bronchoalveolar lavage in haematology patients: influence of bronchoalveolar lavage human DNA content on real-time PCR performance. (18763000)
2009
33
Detection of circulating Aspergillus fumigatus DNA by real-time PCR assay of large serum volumes improves early diagnosis of invasive aspergillosis in high-risk adult patients under hematologic surveillance. (18845828)
2008
34
Invasive aspergillosis: diagnosis, prophylaxis and treatment. (18832929)
2008
35
Invasive aspergillosis in hematopoietic stem cell transplant recipients: a retrospective analysis. (19219277)
2008
36
Aortic thrombus during invasive aspergillosis in a kidney transplant recipient. (18296818)
2008
37
Molecular diagnosis of invasive aspergillosis in patients with hematologic malignancies - new answers to a diagnostic challenge? (23495815)
2008
38
Aspergillus galactomannan antigen in the bronchoalveolar lavage fluid for the diagnosis of invasive aspergillosis in lung transplant recipients. (17519782)
2007
39
Images in HIV/AIDS. Invasive aspergillosis presenting as a neck mass in a person with HIV/AIDS. (17672013)
2007
40
Invasive aspergillosis in the ICU: an emerging disease. (17646965)
2007
41
Invasive aspergillosis in chronic granulomatous disease: report of 7 cases. (16804696)
2007
42
Invasive aspergillosis of the brain: improvement with lyposomal amphoterecin B and itraconazole. (17921665)
2007
43
Disseminated invasive aspergillosis with cerebral involvement successfully treated with caspofungin and voriconazole. (17721739)
2007
44
Is combination antifungal therapy for invasive aspergillosis a necessity in hematopoietic stem-cell transplant recipients? (16804386)
2006
45
Hospital-wide prospective mandatory surveillance of invasive aspergillosis in a French teaching hospital (2000-2002). (16257084)
2006
46
Disseminated invasive aspergillosis. (17299570)
2006
47
Combination therapy with terbinafine and amphotericin B in a rabbit model of experimental invasive aspergillosis. (16251321)
2005
48
Efficacy of 2-(3,4-dimethyl-2,5-dihydro-1h-pyrrole-2-yl)-1-methylethyl pentanoate in a murine model of invasive aspergillosis. (16189123)
2005
49
Granulocyte transfusions in children with chronic granulomatous disease and invasive aspergillosis. (15828925)
2005
50
Comparison of galactomannan detection, PCR-enzyme-linked immunosorbent assay, and real-time PCR for diagnosis of invasive aspergillosis in a neutropenic rat model and effect of caspofungin acetate. (16275948)
2005

Variations for Invasive Aspergillosis

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Expression for genes affiliated with Invasive Aspergillosis

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Search GEO for disease gene expression data for Invasive Aspergillosis.

Pathways for genes affiliated with Invasive Aspergillosis

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Pathways related to Invasive Aspergillosis according to GeneCards Suite gene sharing:

(show all 26)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.0TLR1, TLR6
2
Show member pathways
9.5TLR1, TLR4, TLR6
3
Show member pathways
9.5TLR1, TLR4, TLR6
49.5TLR6, TLR4, TLR1
5
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways58
Immune response IL 1 signaling pathway58
9.3TLR6, TLR4, TLR1, CLEC7A
69.3CLEC7A, TLR1, TLR4, TLR6
7
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway58
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB58
Development Angiopoietin Tie2 signaling58
9.3IFNG, IL17A, PLG
8
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
9.3CD79A, IL17A, IFNG
99.2TLR4, CXCL10, IFNG
10
Show member pathways
thioredoxin pathway36
9.2PLG, IFNG, HBB
119.2TLR4, IFNG, IL17A
12
Show member pathways
9.2TLR4, IFNG, IL17A
139.1CSF3, IFNG
149.1TLR6, TLR4, SFTPD, CLEC7A, MBL2
159.0IFNG, TLR1, TLR4, TLR6
16
Show member pathways
8.9PLG, IFNG, CXCL10, TLR4
17
Show member pathways
8.9CSF3, IL17A, TLR4
188.8TLR6, TLR4, TLR1, CLEC7A, IFNG
19
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.8TLR6, TLR4, TLR1, CXCL10, IFNG
20
Show member pathways
8.7TLR6, TLR4, TLR1, IFNG, IL17A
21
Show member pathways
IL27-mediated signaling events36
8.7TLR6, TLR4, TLR1, IFNG, IL17A
22
Show member pathways
8.7TLR6, TLR4, TLR1, IFNG, CD79A
23
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
8.5IFNG, CXCL10, SFTPD, TLR1, TLR4, TLR6
24
Show member pathways
8.5TLR6, TLR4, TLR1, CXCL10, CSF3
258.3CSF3, IFNG, HBB, TLR4
26
Show member pathways
8.1TLR4, CXCL10, IFNG, IL17A, CSF3

Compounds for genes affiliated with Invasive Aspergillosis

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Compounds related to Invasive Aspergillosis according to GeneCards Suite gene sharing:

(show top 50)    (show all 82)
idCompoundScoreTop Affiliating Genes
1poly(i:c)5910.0TLR1, TLR4, TLR6
2pam3csk4599.9TLR1, TLR4, TLR6
3pam2csk4599.9TLR6, TLR1, TLR4
4resiquimod43 5910.9TLR6, TLR4, TLR1
5flagellin43 2810.8TLR6, TLR1, TLR4
6zymosan439.8CLEC7A, MBL2, TLR4
7lipoteichoic acid439.7MBL2, TLR1, TLR4
8peptidoglycan43 2810.7TLR4, TLR1, TLR6, MBL2
9tuberculin439.7IFNG, MBL2, CD79A
10con a439.6IFNG, MBL2, CD79A
111-methyltryptophan439.6IFNG, TLR4
12polymyxin b439.5TLR4, IFNG, MBL2
13imiquimod43 59 28 1212.4TLR6, TLR4, TLR1, IFNG
14polyinosinic-polycytidylic acid439.4TLR4, IFNG, CXCL10
15azathioprine43 2 49 1212.4CABIN1, TPMT, HBB, CD79A
162,5-oligoadenylate439.4IFNG, CXCL10, TLR4
17neopterin439.4CXCL10, IFNG, MBL2, CD79A
18poly(i-c)439.3TLR4, IFNG, CXCL10
19infliximab43 49 1211.3IL17A, IFNG, CXCL10, TLR4
20ifn-alpha439.3TLR4, CXCL10, IL17A, IFNG
21il 10439.1TLR4, CXCL10, IFNG
22creatinine439.1TPMT, CD79A, MBL2, CXCL10, IL17A
23allergens439.1TLR4, SFTPD, CXCL10, IFNG, CD79A
24ribavirin43 49 1211.0IFNG, CXCL10, MBL2, CSF3
25polysaccharide438.9SFTPD, MBL2, MBL3P, CD79A, TLR4
26pge2438.8CD79A, IL17A, IFNG, CXCL10, TLR4
27ccl343 289.8CSF3, TLR4, CXCL10, IFNG
28histamine43 28 2410.8SFTPD, TPMT, CXCL10, IFNG, CD79A, TLR4
29mannan438.7TLR4, MBL2, CD79A, MBL3P, IL17A, SFTPD
30mycophenolate mofetil43 49 1210.6CSF3, TPMT, CABIN1, CD79A, IFNG
31methotrexate49 43 1210.6TLR4, IL17A, CSF3, CD79A, TPMT
32glucose438.5TLR4, CLEC7A, CXCL10, PLG, SFTPD, MBL2
33lipid438.5TLR4, TLR6, MBL2, TLR1, PLG, SFTPD
34mannose438.5TLR4, CD79A, MBL3P, MBL2, IL17A, CLEC7A
35prednisolone43 28 1210.4SFTPD, TPMT, IFNG, CSF3, MBL2, CD79A
36tacrolimus43 49 1210.4TPMT, IFNG, CD79A, TLR4, CABIN1, IL17A
37steroid438.4PLG, SFTPD, HBB, TPMT, IL17A, CABIN1
38endotoxin438.3TLR4, SFTPD, IL17A, CXCL10, IFNG, CSF3
39anti-fungal438.3CD79A, MBL2, IFNG, SFTPD, TLR4, CSF3
40cysteine438.2IFNG, HBB, MBL2, CD79A, SFTPD, TLR4
41atp43 289.2HBB, PLG, TPMT, CXCL10, MBL2, TLR4
42rantes438.0MBL2, IL17A, CSF3, IFNG, CXCL10, TLR6
43cycloheximide438.0TLR4, CXCL10, CSF3, IFNG, HBB
44thymidine43 249.0IFNG, SFTPD, CSF3, HBB, CXCL10, IL17A
45cyclosporin a43 28 599.8TPMT, TLR4, IL17A, CSF3, CABIN1, CD79A
46nitric oxide43 24 129.8MBL2, TLR4, SFTPD, HBB, CXCL10, IL17A
47calcium43 49 24 1210.7PLB1, TLR4, SFTPD, HBB, CXCL10, MBL2
48vegf437.5CSF3, CD79A, PLG, CXCL10, IFNG, TLR4
49tyrosine437.5CLEC7A, IL17A, CSF3, TLR4, HBB, MBL2
50dexamethasone43 49 28 1210.5MBL2, IL17A, IFNG, CXCL10, TLR4, CLEC7A

GO Terms for genes affiliated with Invasive Aspergillosis

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Cellular components related to Invasive Aspergillosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.5MBL2, PLG, IFNG, CXCL10, HBB, SFTPD
2external side of plasma membraneGO:00098978.2CD79A, IL17A, IFNG, CXCL10, CLEC7A, TLR4
3extracellular spaceGO:00056157.4SFTPD, CXCL10, IFNG, IL17A, PLG, CSF3

Biological processes related to Invasive Aspergillosis according to GeneCards Suite gene sharing:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1detection of triacyl bacterial lipopeptideGO:004249510.3TLR6, TLR1
2positive regulation of phagocytosisGO:005076610.1SFTPD, CLEC7A, MBL2
3macrophage activationGO:004211610.0TLR1, TLR4
4positive regulation of tumor necrosis factor biosynthetic processGO:004253510.0TLR4, TLR1
5T-helper 1 type immune responseGO:00420889.9TLR4, TLR6
6positive regulation of interleukin-23 productionGO:00327479.9IFNG, IL17A
7positive regulation of interleukin-6 biosynthetic processGO:00454109.8TLR6, IFNG, TLR1
8negative regulation of growth of symbiont in hostGO:00441309.8IFNG, MBL2
9positive regulation of MHC class II biosynthetic processGO:00453489.8IFNG, TLR4
10positive regulation of interleukin-12 biosynthetic processGO:00450849.8IFNG, TLR4
11defense response to protozoanGO:00428329.7CLEC7A, IFNG
12negative regulation of interleukin-17 productionGO:00327009.7IFNG, TLR4
13toll-like receptor signaling pathwayGO:00022249.7TLR6, TLR1, TLR4
14positive regulation of tumor necrosis factor productionGO:00327609.6IFNG, CLEC7A, TLR4
15inflammatory responseGO:00069549.5TLR1, IL17A, CXCL10, CLEC7A, TLR6
16positive regulation of osteoclast differentiationGO:00456729.5IFNG, IL17A
17positive regulation of interleukin-12 productionGO:00327359.5TLR4, IFNG
18positive regulation of nitric oxide biosynthetic processGO:00454299.4TLR4, HBB, IFNG
19innate immune responseGO:00450879.2MBL2, SFTPD, TLR1, TLR4, CLEC7A, TLR6
20defense response to bacteriumGO:00427429.2TLR6, TLR4, IFNG, MBL2, SFTPD
21cell surface receptor signaling pathwayGO:00071669.1CXCL10, IFNG, CABIN1
22cellular response to lipopolysaccharideGO:00712229.0CSF3, IFNG, TLR4
23immune responseGO:00069558.5IL17A, TLR4, TLR1, CXCL10, CSF3, TLR6
24positive regulation of transcription from RNA polymerase II promoterGO:00459448.3IL17A, CSF3, IFNG, CXCL10, TLR4

Molecular functions related to Invasive Aspergillosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1transmembrane signaling receptor activityGO:00048888.9CD79A, TLR1, TLR4, TLR6
2cytokine activityGO:00051258.8CSF3, IL17A, IFNG

Products for genes affiliated with Invasive Aspergillosis

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Sources for Invasive Aspergillosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet