MCID: INV004
MIFTS: 38

Invasive Bladder Transitional Cell Carcinoma malady

Cancer diseases, Nephrological diseases categories
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Summaries for Invasive Bladder Transitional Cell Carcinoma

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33MalaCards
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MalaCards: Invasive Bladder Transitional Cell Carcinoma, also known as infiltrating bladder urothelial carcinoma, is related to bladder transitional cell carcinoma and transitional cell carcinoma. An important gene associated with Invasive Bladder Transitional Cell Carcinoma is NOTCH1 (notch 1), and among its related pathways are Notch signaling pathway and Cell cycle Regulation of G1 S transition part 1 . The compounds acnu and 10-hydroxycamptothecin have been mentioned in the context of this disorder. Related mouse phenotypes are craniofacial and tumorigenesis.

Aliases & Classifications for Invasive Bladder Transitional Cell Carcinoma

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8Disease Ontology, 62UMLS, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Nephrological diseases


Aliases & Descriptions:

invasive bladder transitional cell carcinoma 8
infiltrating bladder urothelial carcinoma 62
invasive bladder urothelial carcinoma 8


External Ids:

Disease Ontology8 DOID:6477
NCIt40 C27885

Related Diseases for Invasive Bladder Transitional Cell Carcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Invasive Bladder Transitional Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 42)
idRelated DiseaseScoreTop Affiliating Genes
1bladder transitional cell carcinoma31.2IFI27, TP53
2transitional cell carcinoma31.1TP53, IFI27, CDKN1A
3non-invasive bladder urothelial carcinoma10.5
4laryngeal benign neoplasm10.0TP53, IFI27
5esophageal cancer10.0IFI27, TP53
6cervical adenocarcinoma10.0CDKN1A, IFI27
7li-fraumeni syndrome10.0CDKN1A, TP53
8breast cancer, invasive ductal10.0CDKN1A, TP53
9thyroid cancer, anaplastic10.0CDKN1A, TP53
10breast cancer10.0NOTCH1, IFI27
11oligodendroglioma10.0CDKN1A, TP53
12ataxia telangiectasia10.0CDKN1A, TP53
13thyroid cancer10.0CDKN1A, TP53
14laryngeal squamous cell carcinoma10.0CDKN1A, IFI27, TP53
15papilloma10.0TP53, IFI27, CDKN1A
16oral cancer10.0CDKN1A, IFI27, TP53
17b-cell lymphomas10.0TP53, IFI27, CDKN1A
18endometrial carcinoma10.0TP53, IFI27, CDKN1A
19bladder carcinoma10.0CDKN1A, TP53
20lung cancer10.0TP53, IFI27, CDKN1A
21astrocytoma10.0CDKN1A, IFI27, TP53
22retinoblastoma10.0TP53, IFI27, CDKN1A
23ovarian cancer10.0CDKN1A, IFI27, TP53
24non-small cell lung carcinoma9.9TP53, IFI27, CDKN1A
25malignant glioma9.9CDKN1A, NOTCH1, TP53
26myeloma9.9IFI27, NOTCH1, CDKN1A
27adenoma9.9CDKN1A, IFI27, TP53
28brain cancer9.9TP53, NOTCH1, CDKN1A
29stomach cancer9.9TP53, IFI27, CDKN1A
30glioblastoma multiforme9.9CDKN1A, TP53
31osteosarcoma9.9CDKN1A, NOTCH1, TP53
32colorectal cancer9.9TP53, IFI27, CDKN1A
33cervical cancer9.9TP53, IFI27, NOTCH1, CDKN1A
34pancreatic cancer9.9CDKN1A, NOTCH1, IFI27, TP53
35colon cancer9.9CDKN1A, NOTCH1, IFI27, TP53
36burkitt's lymphoma9.9TP53, IFI27, NOTCH1, CDKN1A
37hepatocellular carcinoma9.9TP53, IFI27, NOTCH1, CDKN1A
38tongue squamous cell carcinoma9.9CDKN1A, NOTCH1, IFI27, TP53
39adenocarcinoma9.9TP53, IFI27, NOTCH1, CDKN1A
40melanoma9.9CDKN1A, NOTCH1, IFI27, TP53
41prostate cancer9.9TP53, IFI27, NOTCH1, CDKN1A
42leukemia9.9CDKN1A, NOTCH1, IFI27, TP53

Graphical network of the top 20 diseases related to Invasive Bladder Transitional Cell Carcinoma:



Diseases related to invasive bladder transitional cell carcinoma

Symptoms for Invasive Bladder Transitional Cell Carcinoma

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Drugs & Therapeutics for Invasive Bladder Transitional Cell Carcinoma

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Invasive Bladder Transitional Cell Carcinoma

Search NIH Clinical Center for Invasive Bladder Transitional Cell Carcinoma

Genetic Tests for Invasive Bladder Transitional Cell Carcinoma

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Anatomical Context for Invasive Bladder Transitional Cell Carcinoma

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Animal Models for Invasive Bladder Transitional Cell Carcinoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Invasive Bladder Transitional Cell Carcinoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053828.9CDKN1A, NOTCH1, TP53
2MP:00020068.8CDKN1A, NOTCH1, TP53
3MP:00053808.4CDKN1A, RBX1, NOTCH1, TP53
4MP:00053848.1TP53, NOTCH1, RBX1, CDKN1A

Publications for Invasive Bladder Transitional Cell Carcinoma

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52PubMed
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Articles related to Invasive Bladder Transitional Cell Carcinoma:

idTitleAuthorsYear
1
Detection of specific chromosomal aberrations in urine using BCA-1 (oligo-CGH-array) enhances diagnostic sensitivity and predicts the aggressiveness of non-muscle-invasive bladder transitional cell carcinoma. (24196429)
2013
2
Parallel proteomic analysis in muscle-invasive bladder transitional cell carcinoma and cancer-related stroma. (23479173)
2013
3
Overexpression of RING box protein-1 (RBX1) associated with poor prognosis of non-muscle-invasive bladder transitional cell carcinoma. (23609182)
2013
4
Expression analysis of NOTCH1/HES1/PTEN signaling pathway in invasive bladder transitional cell carcinoma]. (22781569)
2012
5
Proteomics research on muscle-invasive bladder transitional cell carcinoma. (21645413)
2011
6
Predictive value of cell cycle biomarkers in nonmuscle invasive bladder transitional cell carcinoma. (17222615)
2007
7
Efficacy and tolerability of concurrent weekly low dose cisplatin during radiation treatment of localised muscle invasive bladder transitional cell carcinoma: a report of two sequential Phase II studies from the Trans Tasman Radiation Oncology Group. (17011058)
2006
8
Structural alteration of p53 protein in patients with muscle invasive bladder transitional cell carcinoma. (11696726)
2001

Variations for Invasive Bladder Transitional Cell Carcinoma

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Expression for genes affiliated with Invasive Bladder Transitional Cell Carcinoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Invasive Bladder Transitional Cell Carcinoma

Search GEO for disease gene expression data for Invasive Bladder Transitional Cell Carcinoma.

Pathways for genes affiliated with Invasive Bladder Transitional Cell Carcinoma

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Sources:
50PathCards, 30KEGG, 38NCBI BioSystems Database, 60Thomson Reuters, 55Reactome, 53QIAGEN, 54R&D Systems, 12EMD Millipore, 51PharmGKB, 57SinoBiological
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Pathways related to Invasive Bladder Transitional Cell Carcinoma according to GeneCards/GeneDecks:

(show all 45)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Notch signaling pathway38
9.5NOTCH1, CDKN1A
2
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation60
9.4CDKN1A, RBX1
39.4CDKN1A, RBX1
4
Show member pathways
Cell cycle ESR1 regulation of G1 S transition60
Immune response MIF JAB1 signaling60
Cell cycle Cell cycle generic schema 60
9.4CDKN1A, RBX1
59.4NOTCH1, TP53
6
Show member pathways
9.4NOTCH1, TP53
79.3TP53, CDKN1A
8
Show member pathways
9.3CDKN1A, TP53
99.3TP53, CDKN1A
109.3CDKN1A, TP53
11
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways60
9.3TP53, CDKN1A
129.3TP53, CDKN1A
13
Show member pathways
9.3TP53, CDKN1A
14
Show member pathways
DNA damage response38
9.3CDKN1A, TP53
15
Show member pathways
Immune response IL 4 signaling pathway60
Signal transduction AKT signaling60
9.3CDKN1A, TP53
169.3CDKN1A, TP53
179.3CDKN1A, TP53
18
Show member pathways
9.3CDKN1A, TP53
199.3TP53, CDKN1A
20
Show member pathways
Signal transduction PTEN pathway60
9.3CDKN1A, TP53
21
Show member pathways
ErbB receptor signaling network38
ErbB signaling pathway38
9.3CDKN1A, TP53
22
Show member pathways
9.3TP53, CDKN1A
239.3TP53, CDKN1A
249.3CDKN1A, TP53
259.3CDKN1A, TP53
269.3CDKN1A, TP53
279.3TP53, CDKN1A
289.3CDKN1A, TP53
29
Show member pathways
ATM Signaling Pathway38
9.3TP53, CDKN1A
309.3CDKN1A, TP53
319.3CDKN1A, TP53
32
Show member pathways
9.3CDKN1A, TP53
33
Show member pathways
9.3TP53, CDKN1A
349.3RBX1, TP53
359.3RBX1, TP53
368.9CDKN1A, NOTCH1, TP53
37
Show member pathways
8.9CDKN1A, NOTCH1, TP53
38
Show member pathways
Delta-Notch Signaling Pathway38
Notch Signaling Pathway38
8.9RBX1, NOTCH1, TP53
39
Show member pathways
8.9TP53, NOTCH1, RBX1
40
Show member pathways
8.8CDKN1A, RBX1, TP53
41
Show member pathways
Proteasome Degradation38
Immune response Antigen presentation by MHC class I60
8.8CDKN1A, RBX1, TP53
42
Show member pathways
Cell cycle38
8.8CDKN1A, RBX1, TP53
438.8TP53, RBX1, CDKN1A
448.8TP53, RBX1, CDKN1A
45
Show member pathways
8.4TP53, NOTCH1, RBX1, CDKN1A

Compounds for genes affiliated with Invasive Bladder Transitional Cell Carcinoma

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Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 61Tocris Bioscience, 24HMDB, 51PharmGKB, 3BitterDB
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Compounds related to Invasive Bladder Transitional Cell Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 72)
idCompoundScoreTop Affiliating Genes
1acnu459.8TP53, CDKN1A
210-hydroxycamptothecin459.7CDKN1A, TP53
37-hydroxystaurosporine45 1110.7TP53, CDKN1A
4tomudex459.7TP53, CDKN1A
5hpvs459.7CDKN1A, TP53
63,3-diindolylmethane459.7CDKN1A, TP53
7olomoucine45 1110.7CDKN1A, TP53
8temozolomide45 1110.7CDKN1A, TP53
9taxane459.7TP53, CDKN1A
10noxa459.6CDKN1A, TP53
11cd 437459.6CDKN1A, TP53
12aphidicolin459.6CDKN1A, TP53
13p00048459.6IFI27, CDKN1A
14optimax459.6IFI27, CDKN1A
15depsipeptide459.6CDKN1A, TP53
16mevastatin45 29 1111.5IFI27, CDKN1A
17methylmethanesulfonate459.5CDKN1A, TP53
18suberoylanilide hydroxamic acid459.5TP53, CDKN1A
19n-(4-hydroxyphenyl)retinamide459.5CDKN1A, TP53
20eb 108945 6110.5CDKN1A, IFI27
212-methoxyestradiol45 61 2411.4CDKN1A, TP53
22benzo(a)pyrene459.4CDKN1A, TP53
23leptomycin b45 6110.3TP53, CDKN1A
24oxaliplatin45 51 1111.2CDKN1A, TP53
25flavopiridol45 1110.0CDKN1A, TP53
26rapamycin459.0CDKN1A, NOTCH1, IFI27
27hmba459.0CDKN1A, IFI27, TP53
28indole-3-carbinol459.0CDKN1A, IFI27, TP53
29sulindac45 1110.0TP53, IFI27, CDKN1A
30roscovitine459.0CDKN1A, IFI27, TP53
31genistein45 29 61 3 24 1113.9CDKN1A, NOTCH1, IFI27
32adpribose458.9CDKN1A, IFI27, TP53
33thymidylate458.9CDKN1A, IFI27, TP53
34cytarabine45 51 1110.9TP53, IFI27, CDKN1A
35resveratrol45 61 24 1111.9CDKN1A, IFI27, TP53
36mg 13245 619.9CDKN1A, IFI27, TP53
37retinoid458.9TP53, IFI27, CDKN1A
38n acetylcysteine458.9CDKN1A, IFI27, TP53
39butyrate458.9TP53, IFI27, CDKN1A
40tamoxifen45 51 29 1111.9CDKN1A, IFI27, TP53
41paclitaxel45 51 1110.9TP53, IFI27, CDKN1A
42paraffin458.8TP53, IFI27, CDKN1A
43thymidine45 249.8TP53, IFI27, CDKN1A
44cisplatin45 51 61 1111.8CDKN1A, IFI27, TP53
45progesterone45 29 61 24 1112.5CDKN1A, IFI27, TP53
46ly294002458.5CDKN1A, NOTCH1, IFI27, TP53
47doxorubicin45 51 1110.5TP53, IFI27, NOTCH1, CDKN1A
48vegf458.5CDKN1A, NOTCH1, IFI27, TP53
49estrogen458.5CDKN1A, NOTCH1, IFI27, TP53
50retinoic acid45 249.4CDKN1A, NOTCH1, IFI27, TP53

GO Terms for genes affiliated with Invasive Bladder Transitional Cell Carcinoma

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16Gene Ontology
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Cellular components related to Invasive Bladder Transitional Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:0058298.4CDKN1A, RBX1, NOTCH1, TP53
2nucleoplasmGO:0056548.1CDKN1A, RBX1, NOTCH1, TP53

Biological processes related to Invasive Bladder Transitional Cell Carcinoma according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1mitotic cell cycle arrestGO:0718509.6CDKN1A, TP53
2cellular response to ionizing radiationGO:0714799.6TP53, CDKN1A
3positive regulation of reactive oxygen species metabolic processGO:20003799.5CDKN1A, TP53
4intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGO:0427719.5CDKN1A, TP53
5intrinsic apoptotic signaling pathwayGO:0971939.4CDKN1A, TP53
6DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:0069779.4CDKN1A, TP53
7Ras protein signal transductionGO:0072659.3TP53, CDKN1A
8cell cycle arrestGO:0070509.3CDKN1A, TP53
9cellular response to hypoxiaGO:0714569.2RBX1, TP53
10Notch signaling pathwayGO:0072199.1RBX1, NOTCH1, TP53
11negative regulation of cell growthGO:0303089.0CDKN1A, TP53
12negative regulation of cell proliferationGO:0082859.0TP53, NOTCH1, CDKN1A

Products for genes affiliated with Invasive Bladder Transitional Cell Carcinoma

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Sources for Invasive Bladder Transitional Cell Carcinoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet