MCID: INV004
MIFTS: 38

Invasive Bladder Transitional Cell Carcinoma malady

Cancer diseases, Nephrological diseases categories

Summaries for Invasive Bladder Transitional Cell Carcinoma

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34MalaCards
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MalaCards: Invasive Bladder Transitional Cell Carcinoma, also known as infiltrating bladder urothelial carcinoma, is related to bladder transitional cell carcinoma and transitional cell carcinoma. An important gene associated with Invasive Bladder Transitional Cell Carcinoma is NOTCH1 (notch 1), and among its related pathways are Notch signaling pathway and Cell cycle Regulation of G1 S transition part 1 . The compounds acnu and 10-hydroxycamptothecin have been mentioned in the context of this disorder. Related mouse phenotypes are craniofacial and tumorigenesis.

Aliases & Classifications for Invasive Bladder Transitional Cell Carcinoma

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9Disease Ontology, 63UMLS, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Nephrological diseases


Aliases & Descriptions:

invasive bladder transitional cell carcinoma 9
infiltrating bladder urothelial carcinoma 63
invasive bladder urothelial carcinoma 9


External Ids:

Disease Ontology9 DOID:6477
NCIt41 C27885

Related Diseases for Invasive Bladder Transitional Cell Carcinoma

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18GeneCards, 19GeneDecks
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Diseases related to Invasive Bladder Transitional Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 42)
idRelated DiseaseScoreTop Affiliating Genes
1bladder transitional cell carcinoma31.2IFI27, TP53
2transitional cell carcinoma31.1TP53, IFI27, CDKN1A
3non-invasive bladder urothelial carcinoma10.5
4laryngeal benign neoplasm10.0TP53, IFI27
5esophageal cancer10.0IFI27, TP53
6cervical adenocarcinoma10.0CDKN1A, IFI27
7li-fraumeni syndrome10.0CDKN1A, TP53
8breast cancer, invasive ductal10.0CDKN1A, TP53
9thyroid cancer, anaplastic10.0CDKN1A, TP53
10breast cancer10.0NOTCH1, IFI27
11oligodendroglioma10.0CDKN1A, TP53
12ataxia telangiectasia10.0CDKN1A, TP53
13thyroid cancer10.0CDKN1A, TP53
14laryngeal squamous cell carcinoma10.0CDKN1A, IFI27, TP53
15papilloma10.0TP53, IFI27, CDKN1A
16oral cancer10.0CDKN1A, IFI27, TP53
17b-cell lymphomas10.0TP53, IFI27, CDKN1A
18endometrial carcinoma10.0TP53, IFI27, CDKN1A
19bladder carcinoma10.0CDKN1A, TP53
20lung cancer10.0TP53, IFI27, CDKN1A
21astrocytoma10.0CDKN1A, IFI27, TP53
22retinoblastoma10.0TP53, IFI27, CDKN1A
23ovarian cancer10.0CDKN1A, IFI27, TP53
24non-small cell lung carcinoma9.9TP53, IFI27, CDKN1A
25malignant glioma9.9CDKN1A, NOTCH1, TP53
26myeloma9.9IFI27, NOTCH1, CDKN1A
27adenoma9.9CDKN1A, IFI27, TP53
28brain cancer9.9TP53, NOTCH1, CDKN1A
29stomach cancer9.9TP53, IFI27, CDKN1A
30glioblastoma multiforme9.9CDKN1A, TP53
31osteosarcoma9.9CDKN1A, NOTCH1, TP53
32colorectal cancer9.9TP53, IFI27, CDKN1A
33cervical cancer9.9TP53, IFI27, NOTCH1, CDKN1A
34pancreatic cancer9.9CDKN1A, NOTCH1, IFI27, TP53
35colon cancer9.9CDKN1A, NOTCH1, IFI27, TP53
36burkitt's lymphoma9.9TP53, IFI27, NOTCH1, CDKN1A
37hepatocellular carcinoma9.9TP53, IFI27, NOTCH1, CDKN1A
38tongue squamous cell carcinoma9.9CDKN1A, NOTCH1, IFI27, TP53
39adenocarcinoma9.9TP53, IFI27, NOTCH1, CDKN1A
40melanoma9.9CDKN1A, NOTCH1, IFI27, TP53
41prostate cancer9.9TP53, IFI27, NOTCH1, CDKN1A
42leukemia9.9CDKN1A, NOTCH1, IFI27, TP53

Graphical network of the top 20 diseases related to Invasive Bladder Transitional Cell Carcinoma:



Diseases related to invasive bladder transitional cell carcinoma

Symptoms for Invasive Bladder Transitional Cell Carcinoma

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Drugs & Therapeutics for Invasive Bladder Transitional Cell Carcinoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Invasive Bladder Transitional Cell Carcinoma

Drug clinical trials:

Search ClinicalTrials for Invasive Bladder Transitional Cell Carcinoma

Search NIH Clinical Center for Invasive Bladder Transitional Cell Carcinoma

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Genetic Tests for Invasive Bladder Transitional Cell Carcinoma

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Anatomical Context for Invasive Bladder Transitional Cell Carcinoma

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Animal Models for Invasive Bladder Transitional Cell Carcinoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Invasive Bladder Transitional Cell Carcinoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053828.9CDKN1A, NOTCH1, TP53
2MP:00020068.8CDKN1A, NOTCH1, TP53
3MP:00053808.4CDKN1A, RBX1, NOTCH1, TP53
4MP:00053848.1TP53, NOTCH1, RBX1, CDKN1A

Publications for Invasive Bladder Transitional Cell Carcinoma

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53PubMed
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Articles related to Invasive Bladder Transitional Cell Carcinoma:

idTitleAuthorsYear
1
Detection of specific chromosomal aberrations in urine using BCA-1 (oligo-CGH-array) enhances diagnostic sensitivity and predicts the aggressiveness of non-muscle-invasive bladder transitional cell carcinoma. (24196429)
2013
2
Parallel proteomic analysis in muscle-invasive bladder transitional cell carcinoma and cancer-related stroma. (23479173)
2013
3
Overexpression of RING box protein-1 (RBX1) associated with poor prognosis of non-muscle-invasive bladder transitional cell carcinoma. (23609182)
2013
4
Expression analysis of NOTCH1/HES1/PTEN signaling pathway in invasive bladder transitional cell carcinoma]. (22781569)
2012
5
Proteomics research on muscle-invasive bladder transitional cell carcinoma. (21645413)
2011
6
Predictive value of cell cycle biomarkers in nonmuscle invasive bladder transitional cell carcinoma. (17222615)
2007
7
Efficacy and tolerability of concurrent weekly low dose cisplatin during radiation treatment of localised muscle invasive bladder transitional cell carcinoma: a report of two sequential Phase II studies from the Trans Tasman Radiation Oncology Group. (17011058)
2006
8
Structural alteration of p53 protein in patients with muscle invasive bladder transitional cell carcinoma. (11696726)
2001

Variations for Invasive Bladder Transitional Cell Carcinoma

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Expression for genes affiliated with Invasive Bladder Transitional Cell Carcinoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Invasive Bladder Transitional Cell Carcinoma

Search GEO for disease gene expression data for Invasive Bladder Transitional Cell Carcinoma.

Pathways for genes affiliated with Invasive Bladder Transitional Cell Carcinoma

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Sources:
51PathCards, 31KEGG, 39NCBI BioSystems Database, 61Thomson Reuters, 56Reactome, 54QIAGEN, 55R&D Systems, 13EMD Millipore, 52PharmGKB, 58SinoBiological
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Pathways related to Invasive Bladder Transitional Cell Carcinoma according to GeneCards/GeneDecks:

(show all 45)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Notch signaling pathway39
9.5NOTCH1, CDKN1A
2
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation61
9.4CDKN1A, RBX1
39.4CDKN1A, RBX1
4
Show member pathways
Cell cycle ESR1 regulation of G1 S transition61
Immune response MIF JAB1 signaling61
Cell cycle Cell cycle generic schema 61
9.4CDKN1A, RBX1
59.4NOTCH1, TP53
6
Show member pathways
9.4NOTCH1, TP53
79.3TP53, CDKN1A
8
Show member pathways
9.3CDKN1A, TP53
99.3TP53, CDKN1A
109.3CDKN1A, TP53
11
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways61
9.3TP53, CDKN1A
129.3TP53, CDKN1A
13
Show member pathways
9.3TP53, CDKN1A
14
Show member pathways
DNA damage response39
9.3CDKN1A, TP53
15
Show member pathways
Immune response IL 4 signaling pathway61
Signal transduction AKT signaling61
9.3CDKN1A, TP53
169.3CDKN1A, TP53
179.3CDKN1A, TP53
18
Show member pathways
9.3CDKN1A, TP53
199.3TP53, CDKN1A
20
Show member pathways
Signal transduction PTEN pathway61
9.3CDKN1A, TP53
21
Show member pathways
ErbB receptor signaling network39
ErbB signaling pathway39
9.3CDKN1A, TP53
22
Show member pathways
9.3TP53, CDKN1A
239.3TP53, CDKN1A
249.3CDKN1A, TP53
259.3CDKN1A, TP53
269.3CDKN1A, TP53
279.3TP53, CDKN1A
289.3CDKN1A, TP53
29
Show member pathways
ATM Signaling Pathway39
9.3TP53, CDKN1A
309.3CDKN1A, TP53
319.3CDKN1A, TP53
32
Show member pathways
9.3CDKN1A, TP53
33
Show member pathways
9.3TP53, CDKN1A
349.3RBX1, TP53
359.3RBX1, TP53
368.9CDKN1A, NOTCH1, TP53
37
Show member pathways
8.9CDKN1A, NOTCH1, TP53
38
Show member pathways
Delta-Notch Signaling Pathway39
Notch Signaling Pathway39
8.9RBX1, NOTCH1, TP53
39
Show member pathways
8.9TP53, NOTCH1, RBX1
40
Show member pathways
8.8CDKN1A, RBX1, TP53
41
Show member pathways
Proteasome Degradation39
Immune response Antigen presentation by MHC class I61
8.8CDKN1A, RBX1, TP53
42
Show member pathways
Cell cycle39
8.8CDKN1A, RBX1, TP53
438.8TP53, RBX1, CDKN1A
448.8TP53, RBX1, CDKN1A
45
Show member pathways
8.4TP53, NOTCH1, RBX1, CDKN1A

Compounds for genes affiliated with Invasive Bladder Transitional Cell Carcinoma

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Sources:
46Novoseek, 12DrugBank, 30IUPHAR, 62Tocris Bioscience, 25HMDB, 52PharmGKB, 3BitterDB
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Compounds related to Invasive Bladder Transitional Cell Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 72)
idCompoundScoreTop Affiliating Genes
1acnu469.8TP53, CDKN1A
210-hydroxycamptothecin469.7CDKN1A, TP53
37-hydroxystaurosporine46 1210.7TP53, CDKN1A
4tomudex469.7TP53, CDKN1A
5hpvs469.7CDKN1A, TP53
63,3-diindolylmethane469.7CDKN1A, TP53
7olomoucine46 1210.7CDKN1A, TP53
8temozolomide46 1210.7CDKN1A, TP53
9taxane469.7TP53, CDKN1A
10noxa469.6CDKN1A, TP53
11cd 437469.6CDKN1A, TP53
12aphidicolin469.6CDKN1A, TP53
13p00048469.6IFI27, CDKN1A
14optimax469.6IFI27, CDKN1A
15depsipeptide469.6CDKN1A, TP53
16mevastatin46 30 1211.5IFI27, CDKN1A
17methylmethanesulfonate469.5CDKN1A, TP53
18suberoylanilide hydroxamic acid469.5TP53, CDKN1A
19n-(4-hydroxyphenyl)retinamide469.5CDKN1A, TP53
20eb 108946 6210.5CDKN1A, IFI27
212-methoxyestradiol46 62 2511.4CDKN1A, TP53
22benzo(a)pyrene469.4CDKN1A, TP53
23leptomycin b46 6210.3TP53, CDKN1A
24oxaliplatin46 52 1211.2CDKN1A, TP53
25flavopiridol46 1210.0CDKN1A, TP53
26rapamycin469.0CDKN1A, NOTCH1, IFI27
27hmba469.0CDKN1A, IFI27, TP53
28indole-3-carbinol469.0CDKN1A, IFI27, TP53
29sulindac46 1210.0TP53, IFI27, CDKN1A
30roscovitine469.0CDKN1A, IFI27, TP53
31genistein46 30 62 3 25 1213.9CDKN1A, NOTCH1, IFI27
32adpribose468.9CDKN1A, IFI27, TP53
33thymidylate468.9CDKN1A, IFI27, TP53
34cytarabine46 52 1210.9TP53, IFI27, CDKN1A
35resveratrol46 62 25 1211.9CDKN1A, IFI27, TP53
36mg 13246 629.9CDKN1A, IFI27, TP53
37retinoid468.9TP53, IFI27, CDKN1A
38n acetylcysteine468.9CDKN1A, IFI27, TP53
39butyrate468.9TP53, IFI27, CDKN1A
40tamoxifen46 52 30 1211.9CDKN1A, IFI27, TP53
41paclitaxel46 52 1210.9TP53, IFI27, CDKN1A
42paraffin468.8TP53, IFI27, CDKN1A
43thymidine46 259.8TP53, IFI27, CDKN1A
44cisplatin46 52 62 1211.8CDKN1A, IFI27, TP53
45progesterone46 30 62 25 1212.5CDKN1A, IFI27, TP53
46ly294002468.5CDKN1A, NOTCH1, IFI27, TP53
47doxorubicin46 52 1210.5TP53, IFI27, NOTCH1, CDKN1A
48vegf468.5CDKN1A, NOTCH1, IFI27, TP53
49estrogen468.5CDKN1A, NOTCH1, IFI27, TP53
50retinoic acid46 259.4CDKN1A, NOTCH1, IFI27, TP53

GO Terms for genes affiliated with Invasive Bladder Transitional Cell Carcinoma

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17Gene Ontology
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Cellular components related to Invasive Bladder Transitional Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:0058298.4CDKN1A, RBX1, NOTCH1, TP53
2nucleoplasmGO:0056548.1CDKN1A, RBX1, NOTCH1, TP53

Biological processes related to Invasive Bladder Transitional Cell Carcinoma according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1mitotic cell cycle arrestGO:0718509.6CDKN1A, TP53
2cellular response to ionizing radiationGO:0714799.6TP53, CDKN1A
3positive regulation of reactive oxygen species metabolic processGO:20003799.5CDKN1A, TP53
4intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGO:0427719.5CDKN1A, TP53
5intrinsic apoptotic signaling pathwayGO:0971939.4CDKN1A, TP53
6DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:0069779.4CDKN1A, TP53
7Ras protein signal transductionGO:0072659.3TP53, CDKN1A
8cell cycle arrestGO:0070509.3CDKN1A, TP53
9cellular response to hypoxiaGO:0714569.2RBX1, TP53
10Notch signaling pathwayGO:0072199.1RBX1, NOTCH1, TP53
11negative regulation of cell growthGO:0303089.0CDKN1A, TP53
12negative regulation of cell proliferationGO:0082859.0TP53, NOTCH1, CDKN1A

Products for genes affiliated with Invasive Bladder Transitional Cell Carcinoma

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Sources for Invasive Bladder Transitional Cell Carcinoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet