MCID: INV004
MIFTS: 37

Invasive Bladder Transitional Cell Carcinoma malady

Cancer diseases, Nephrological diseases categories

Summaries for Invasive Bladder Transitional Cell Carcinoma

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MalaCards based summary: Invasive Bladder Transitional Cell Carcinoma, also known as infiltrating bladder urothelial carcinoma, is related to bladder transitional cell carcinoma and transitional cell carcinoma. An important gene associated with Invasive Bladder Transitional Cell Carcinoma is NOTCH1 (notch 1), and among its related pathways are Notch signaling pathway and Cell cycle Regulation of G1 S transition part 1 . The compounds acnu and 10-hydroxycamptothecin have been mentioned in the context of this disorder. Related mouse phenotypes are craniofacial and tumorigenesis.

Aliases & Classifications for Invasive Bladder Transitional Cell Carcinoma

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Invasive Bladder Transitional Cell Carcinoma, Aliases & Descriptions:

Name: Invasive Bladder Transitional Cell Carcinoma 9 61
Infiltrating Bladder Urothelial Carcinoma 61
 
Invasive Bladder Urothelial Carcinoma 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Nephrological diseases


External Ids:

Disease Ontology9 DOID:6477
NCIt39 C27885

Related Diseases for Invasive Bladder Transitional Cell Carcinoma

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Diseases related to Invasive Bladder Transitional Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 44)
idRelated DiseaseScoreTop Affiliating Genes
1bladder transitional cell carcinoma31.5IFI27, TP53
2transitional cell carcinoma31.0IFI27, TP53, CDKN1A
3non-invasive bladder urothelial carcinoma10.6
4laryngeal benign neoplasm10.2TP53, IFI27
5esophageal cancer10.1IFI27, TP53
6cervical adenocarcinoma10.1IFI27, CDKN1A
7li-fraumeni syndrome10.1CDKN1A, TP53
8breast cancer, invasive ductal10.0CDKN1A, TP53
9thyroid cancer, anaplastic10.0TP53, CDKN1A
10breast cancer10.0NOTCH1, IFI27
11oligodendroglioma10.0TP53, CDKN1A
12ataxia telangiectasia9.9TP53, CDKN1A
13squamous cell carcinoma of the head and neck9.9CDKN1A, TP53
14laryngeal squamous cell carcinoma9.9CDKN1A, IFI27, TP53
15thyroid hurthle cell carcinoma9.9TP53, CDKN1A
16papilloma9.9CDKN1A, IFI27, TP53
17oral cancer9.9IFI27, CDKN1A, TP53
18b-cell lymphomas9.9CDKN1A, TP53, IFI27
19endometrial carcinoma9.9IFI27, CDKN1A, TP53
20bladder carcinoma9.8CDKN1A, TP53
21lung cancer9.8CDKN1A, IFI27, TP53
22astrocytoma9.8TP53, IFI27, CDKN1A
23retinoblastoma9.8CDKN1A, TP53, IFI27
24ovarian cancer9.8IFI27, CDKN1A, TP53
25glioblastoma9.8IFI27, CDKN1A, TP53
26non-small cell lung carcinoma9.8IFI27, TP53, CDKN1A
27adenoma9.8CDKN1A, TP53, IFI27
28myeloma9.8CDKN1A, IFI27, NOTCH1
29malignant glioma9.8NOTCH1, CDKN1A, TP53
30stomach cancer9.8TP53, IFI27, CDKN1A
31brain cancer9.8NOTCH1, TP53, CDKN1A
32osteosarcoma9.8CDKN1A, NOTCH1, TP53
33glioblastoma multiforme9.8CDKN1A, TP53
34colorectal cancer9.7CDKN1A, IFI27, TP53
35cervical cancer9.6NOTCH1, IFI27, TP53, CDKN1A
36pancreatic cancer9.6TP53, IFI27, NOTCH1, CDKN1A
37colonic benign neoplasm9.6CDKN1A, IFI27, TP53, NOTCH1
38burkitt's lymphoma9.6NOTCH1, CDKN1A, IFI27, TP53
39liver cancer9.6CDKN1A, IFI27, NOTCH1, TP53
40tongue squamous cell carcinoma9.6NOTCH1, TP53, CDKN1A, IFI27
41adenocarcinoma9.6CDKN1A, IFI27, TP53, NOTCH1
42melanoma9.6TP53, NOTCH1, CDKN1A, IFI27
43prostate cancer9.6TP53, NOTCH1, CDKN1A, IFI27
44leukemia9.6TP53, IFI27, NOTCH1, CDKN1A

Graphical network of the top 20 diseases related to Invasive Bladder Transitional Cell Carcinoma:



Diseases related to invasive bladder transitional cell carcinoma

Symptoms for Invasive Bladder Transitional Cell Carcinoma

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Drugs & Therapeutics for Invasive Bladder Transitional Cell Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Invasive Bladder Transitional Cell Carcinoma

Search NIH Clinical Center for Invasive Bladder Transitional Cell Carcinoma

Genetic Tests for Invasive Bladder Transitional Cell Carcinoma

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Anatomical Context for Invasive Bladder Transitional Cell Carcinoma

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Animal Models for Invasive Bladder Transitional Cell Carcinoma or affiliated genes

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MGI Mouse Phenotypes related to Invasive Bladder Transitional Cell Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053828.9CDKN1A, NOTCH1, TP53
2MP:00020068.8CDKN1A, NOTCH1, TP53
3MP:00053808.4CDKN1A, RBX1, NOTCH1, TP53
4MP:00053848.1TP53, NOTCH1, RBX1, CDKN1A

Publications for Invasive Bladder Transitional Cell Carcinoma

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Articles related to Invasive Bladder Transitional Cell Carcinoma:

idTitleAuthorsYear
1
Detection of specific chromosomal aberrations in urine using BCA-1 (oligo-CGH-array) enhances diagnostic sensitivity and predicts the aggressiveness of non-muscle-invasive bladder transitional cell carcinoma. (24196429)
2013
2
Parallel proteomic analysis in muscle-invasive bladder transitional cell carcinoma and cancer-related stroma. (23479173)
2013
3
Overexpression of RING box protein-1 (RBX1) associated with poor prognosis of non-muscle-invasive bladder transitional cell carcinoma. (23609182)
2013
4
Expression analysis of NOTCH1/HES1/PTEN signaling pathway in invasive bladder transitional cell carcinoma]. (22781569)
2012
5
Predictive value of cell cycle biomarkers in nonmuscle invasive bladder transitional cell carcinoma. (17222615)
2007
6
Efficacy and tolerability of concurrent weekly low dose cisplatin during radiation treatment of localised muscle invasive bladder transitional cell carcinoma: a report of two sequential Phase II studies from the Trans Tasman Radiation Oncology Group. (17011058)
2006
7
Structural alteration of p53 protein in patients with muscle invasive bladder transitional cell carcinoma. (11696726)
2001

Variations for Invasive Bladder Transitional Cell Carcinoma

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Expression for genes affiliated with Invasive Bladder Transitional Cell Carcinoma

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Expression patterns in normal tissues for genes affiliated with Invasive Bladder Transitional Cell Carcinoma

Search GEO for disease gene expression data for Invasive Bladder Transitional Cell Carcinoma.

Pathways for genes affiliated with Invasive Bladder Transitional Cell Carcinoma

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Pathways related to Invasive Bladder Transitional Cell Carcinoma according to GeneCards/GeneDecks:

(show all 45)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Notch signaling pathway37
9.5NOTCH1, CDKN1A
2
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation59
9.4CDKN1A, RBX1
39.4CDKN1A, RBX1
4
Show member pathways
Cell cycle ESR1 regulation of G1 S transition59
Immune response MIF JAB1 signaling59
Cell cycle Cell cycle generic schema 59
9.4CDKN1A, RBX1
59.4NOTCH1, TP53
6
Show member pathways
9.4NOTCH1, TP53
79.3TP53, CDKN1A
8
Show member pathways
9.3CDKN1A, TP53
99.3TP53, CDKN1A
109.3CDKN1A, TP53
11
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways59
9.3TP53, CDKN1A
129.3TP53, CDKN1A
13
Show member pathways
9.3TP53, CDKN1A
14
Show member pathways
DNA damage response37
9.3CDKN1A, TP53
15
Show member pathways
Immune response IL 4 signaling pathway59
Signal transduction AKT signaling59
9.3CDKN1A, TP53
169.3CDKN1A, TP53
179.3CDKN1A, TP53
18
Show member pathways
9.3CDKN1A, TP53
199.3TP53, CDKN1A
20
Show member pathways
Signal transduction PTEN pathway59
9.3CDKN1A, TP53
21
Show member pathways
ErbB receptor signaling network37
ErbB signaling pathway37
9.3CDKN1A, TP53
22
Show member pathways
9.3TP53, CDKN1A
239.3TP53, CDKN1A
249.3CDKN1A, TP53
259.3CDKN1A, TP53
269.3CDKN1A, TP53
279.3TP53, CDKN1A
289.3CDKN1A, TP53
29
Show member pathways
ATM Signaling Pathway37
9.3TP53, CDKN1A
309.3CDKN1A, TP53
319.3CDKN1A, TP53
32
Show member pathways
9.3CDKN1A, TP53
33
Show member pathways
9.3TP53, CDKN1A
349.3RBX1, TP53
359.3RBX1, TP53
368.9CDKN1A, NOTCH1, TP53
37
Show member pathways
8.9CDKN1A, NOTCH1, TP53
38
Show member pathways
Delta-Notch Signaling Pathway37
Notch Signaling Pathway37
8.9RBX1, NOTCH1, TP53
39
Show member pathways
8.9TP53, NOTCH1, RBX1
40
Show member pathways
8.8CDKN1A, RBX1, TP53
41
Show member pathways
Proteasome Degradation37
Immune response Antigen presentation by MHC class I59
8.8CDKN1A, RBX1, TP53
42
Show member pathways
Cell cycle37
8.8CDKN1A, RBX1, TP53
438.8TP53, RBX1, CDKN1A
448.8TP53, RBX1, CDKN1A
45
Show member pathways
8.4TP53, NOTCH1, RBX1, CDKN1A

Compounds for genes affiliated with Invasive Bladder Transitional Cell Carcinoma

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Compounds related to Invasive Bladder Transitional Cell Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 72)
idCompoundScoreTop Affiliating Genes
1acnu449.8TP53, CDKN1A
210-hydroxycamptothecin449.7CDKN1A, TP53
37-hydroxystaurosporine44 1210.7TP53, CDKN1A
4tomudex449.7TP53, CDKN1A
5hpvs449.7CDKN1A, TP53
63,3-diindolylmethane449.7CDKN1A, TP53
7olomoucine44 1210.7CDKN1A, TP53
8temozolomide44 1210.7CDKN1A, TP53
9taxane449.7TP53, CDKN1A
10noxa449.6CDKN1A, TP53
11cd 437449.6CDKN1A, TP53
12aphidicolin449.6CDKN1A, TP53
13p00048449.6IFI27, CDKN1A
14optimax449.6IFI27, CDKN1A
15depsipeptide449.6CDKN1A, TP53
16mevastatin44 29 1211.5IFI27, CDKN1A
17methylmethanesulfonate449.5CDKN1A, TP53
18suberoylanilide hydroxamic acid449.5TP53, CDKN1A
19n-(4-hydroxyphenyl)retinamide449.5CDKN1A, TP53
20eb 108944 6010.5CDKN1A, IFI27
212-methoxyestradiol44 60 2511.4CDKN1A, TP53
22benzo(a)pyrene449.4CDKN1A, TP53
23leptomycin b44 6010.3TP53, CDKN1A
24oxaliplatin44 50 1211.2CDKN1A, TP53
25flavopiridol44 1210.0CDKN1A, TP53
26rapamycin449.0CDKN1A, NOTCH1, IFI27
27hmba449.0CDKN1A, IFI27, TP53
28indole-3-carbinol449.0CDKN1A, IFI27, TP53
29sulindac44 1210.0TP53, IFI27, CDKN1A
30roscovitine449.0CDKN1A, IFI27, TP53
31genistein44 29 60 3 25 1213.9CDKN1A, NOTCH1, IFI27
32adpribose448.9CDKN1A, IFI27, TP53
33thymidylate448.9CDKN1A, IFI27, TP53
34cytarabine44 50 1210.9TP53, IFI27, CDKN1A
35resveratrol44 60 25 1211.9CDKN1A, IFI27, TP53
36mg 13244 609.9CDKN1A, IFI27, TP53
37retinoid448.9TP53, IFI27, CDKN1A
38n acetylcysteine448.9CDKN1A, IFI27, TP53
39butyrate448.9TP53, IFI27, CDKN1A
40tamoxifen44 50 29 1211.9CDKN1A, IFI27, TP53
41paclitaxel44 50 1210.9TP53, IFI27, CDKN1A
42paraffin448.8TP53, IFI27, CDKN1A
43thymidine44 259.8TP53, IFI27, CDKN1A
44cisplatin44 50 60 1211.8CDKN1A, IFI27, TP53
45progesterone44 29 60 25 1212.5CDKN1A, IFI27, TP53
46ly294002448.5CDKN1A, NOTCH1, IFI27, TP53
47doxorubicin44 50 1210.5TP53, IFI27, NOTCH1, CDKN1A
48vegf448.5CDKN1A, NOTCH1, IFI27, TP53
49estrogen448.5CDKN1A, NOTCH1, IFI27, TP53
50retinoic acid44 259.4CDKN1A, NOTCH1, IFI27, TP53

GO Terms for genes affiliated with Invasive Bladder Transitional Cell Carcinoma

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Cellular components related to Invasive Bladder Transitional Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:0058298.4CDKN1A, RBX1, NOTCH1, TP53
2nucleoplasmGO:0056548.1CDKN1A, RBX1, NOTCH1, TP53

Biological processes related to Invasive Bladder Transitional Cell Carcinoma according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1mitotic cell cycle arrestGO:0718509.6CDKN1A, TP53
2cellular response to ionizing radiationGO:0714799.6TP53, CDKN1A
3positive regulation of reactive oxygen species metabolic processGO:20003799.5CDKN1A, TP53
4intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGO:0427719.5CDKN1A, TP53
5intrinsic apoptotic signaling pathwayGO:0971939.4CDKN1A, TP53
6DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:0069779.4CDKN1A, TP53
7Ras protein signal transductionGO:0072659.3TP53, CDKN1A
8cell cycle arrestGO:0070509.3CDKN1A, TP53
9cellular response to hypoxiaGO:0714569.2RBX1, TP53
10Notch signaling pathwayGO:0072199.1RBX1, NOTCH1, TP53
11negative regulation of cell growthGO:0303089.0CDKN1A, TP53
12negative regulation of cell proliferationGO:0082859.0TP53, NOTCH1, CDKN1A

Products for genes affiliated with Invasive Bladder Transitional Cell Carcinoma

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Sources for Invasive Bladder Transitional Cell Carcinoma

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4CDC
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23GTR
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26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
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46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet