MCID: INV004
MIFTS: 37

Invasive Bladder Transitional Cell Carcinoma

Categories: Cancer diseases, Nephrological diseases

Aliases & Classifications for Invasive Bladder Transitional Cell Carcinoma

MalaCards integrated aliases for Invasive Bladder Transitional Cell Carcinoma:

Name: Invasive Bladder Transitional Cell Carcinoma 12 14
Infiltrating Bladder Urothelial Carcinoma 69
Invasive Bladder Urothelial Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6477
NCIt 46 C27885
UMLS 69 C1334281

Summaries for Invasive Bladder Transitional Cell Carcinoma

MalaCards based summary : Invasive Bladder Transitional Cell Carcinoma, also known as infiltrating bladder urothelial carcinoma, is related to transitional cell carcinoma and bladder urothelial carcinoma, and has symptoms including dysuria An important gene associated with Invasive Bladder Transitional Cell Carcinoma is NOTCH1 (Notch 1), and among its related pathways/superpathways are Gastric cancer and Relaxin signaling pathway. The drugs Cisplatin and Gemcitabine have been mentioned in the context of this disorder. Affiliated tissues include endothelial, prostate and kidney, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Invasive Bladder Transitional Cell Carcinoma

Diseases related to Invasive Bladder Transitional Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
# Related Disease Score Top Affiliating Genes
1 transitional cell carcinoma 29.9 TP53 UPK3A
2 bladder urothelial carcinoma 29.9 TP53 UPK3A
3 non-invasive bladder urothelial carcinoma 12.3
4 splenic diffuse red pulp small b-cell lymphoma 10.2 NOTCH1 TP53
5 tetraploidy 10.2 NOTCH1 TP53
6 bone squamous cell carcinoma 10.2 NOTCH1 TP53
7 spinal cord astrocytoma 10.2 NOTCH1 TP53
8 richter's syndrome 10.2 NOTCH1 TP53
9 actinic cheilitis 10.2 CDKN1A TP53
10 non-invasive bladder papillary urothelial neoplasm 10.2 TP53 UPK3A
11 bladder transitional cell papilloma 10.2 CDKN1A TP53
12 atypical follicular adenoma 10.2 CDKN1A TP53
13 lip cancer 10.2 CDKN1A TP53
14 suppressor of tumorigenicity 3 10.1 CDKN1A TP53
15 cheilitis 10.1 CDKN1A TP53
16 vulva cancer 10.1 TP53 UPK3A
17 malignant mesenchymoma 10.1 CDKN1A TP53
18 serous cystadenocarcinoma 10.1 CDKN1A TP53
19 keratoacanthoma 10.1 CDKN1A TP53
20 retinal cancer 10.1 CDKN1A TP53
21 sensory system cancer 10.1 CDKN1A TP53
22 cystadenocarcinoma 10.1 CDKN1A TP53
23 tongue cancer 10.1 CDKN1A TP53
24 cervical adenocarcinoma 10.1 CDKN1A TP53
25 ocular cancer 10.1 CDKN1A TP53
26 skin melanoma 10.1 CDKN1A TP53
27 testicular germ cell tumor 10.0 CDKN1A TP53
28 cystitis 10.0 TP53 UPK3A
29 intrahepatic cholangiocarcinoma 10.0 NOTCH1 TP53
30 nervous system cancer 10.0 CDKN1A TP53
31 breast adenocarcinoma 10.0 CDKN1A TP53
32 li-fraumeni syndrome 10.0 CDKN1A TP53
33 acute lymphocytic leukemia 9.9 NOTCH1 TP53
34 blood group, i system 9.9
35 gastrointestinal system cancer 9.9 CDKN1A TP53
36 cervical cancer 9.8 CDKN1A NOTCH1 TP53
37 squamous cell carcinoma 9.8 CDKN1A NOTCH1 TP53
38 bladder cancer 9.5 CDKN1A TP53 UPK3A

Graphical network of the top 20 diseases related to Invasive Bladder Transitional Cell Carcinoma:



Diseases related to Invasive Bladder Transitional Cell Carcinoma

Symptoms & Phenotypes for Invasive Bladder Transitional Cell Carcinoma

UMLS symptoms related to Invasive Bladder Transitional Cell Carcinoma:


dysuria

GenomeRNAi Phenotypes related to Invasive Bladder Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

25 (show all 17)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-108 9.62 CDKN1A
2 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.62 TP53
3 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.62 TP53
4 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.62 TP53
5 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.62 TP53
6 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.62 HOXA13
7 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.62 HOXA13
8 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.62 HOXA13 TP53
9 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.62 TP53
10 Increased shRNA abundance (Z-score > 2) GR00366-A-210 9.62 HOXA13
11 Increased shRNA abundance (Z-score > 2) GR00366-A-22 9.62 HOXA13
12 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.62 CDKN1A
13 Increased shRNA abundance (Z-score > 2) GR00366-A-35 9.62 TP53
14 Increased shRNA abundance (Z-score > 2) GR00366-A-39 9.62 CDKN1A HOXA13 TP53
15 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.62 CDKN1A
16 Increased shRNA abundance (Z-score > 2) GR00366-A-76 9.62 CDKN1A
17 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.62 CDKN1A

MGI Mouse Phenotypes related to Invasive Bladder Transitional Cell Carcinoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.26 NOTCH1 TP53 CDKN1A HOXA13
2 renal/urinary system MP:0005367 9.02 TP53 UPK3A CDKN1A HOXA13 NOTCH1

Drugs & Therapeutics for Invasive Bladder Transitional Cell Carcinoma

Drugs for Invasive Bladder Transitional Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 3,Phase 2 15663-27-1 2767 441203 84093
2
Gemcitabine Approved Phase 3,Phase 2 95058-81-4 60750
3
Bevacizumab Approved, Investigational Phase 3 216974-75-3
4 Anti-Infective Agents Phase 3,Phase 2
5 Immunosuppressive Agents Phase 3,Phase 2
6 Antimetabolites Phase 3,Phase 2
7 Antimetabolites, Antineoplastic Phase 3,Phase 2
8 Antiviral Agents Phase 3,Phase 2
9 Mitogens Phase 3
10 Angiogenesis Inhibitors Phase 3
11 Angiogenesis Modulating Agents Phase 3
12 Antibodies, Monoclonal Phase 3
13 Endothelial Growth Factors Phase 3
14 Immunoglobulins Phase 3
15 Antibodies Phase 3
16
Pembrolizumab Approved Phase 2 1374853-91-4
17
Altretamine Approved Phase 1 645-05-6 2123

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Gemcitabine Hydrochloride and Cisplatin With or Without Bevacizumab in Treating Patients With Advanced Urinary Tract Cancer Active, not recruiting NCT00942331 Phase 3 Cisplatin;Gemcitabine Hydrochloride
2 Bristol Bladder Trial Recruiting NCT01616875 Phase 2 Cabazitaxel + Cisplatin chemotherapy
3 A Phase II Trial Evaluating an Organ-conserving Strategy by Radiochemotherapy for Muscle-infiltrative Bladder Cancer Recruiting NCT01495676 Phase 2
4 Radiation Therapy and Pembrolizumab in Treating Patients With Localized Urothelial Bladder Cancer Not yet recruiting NCT03419130 Phase 2
5 sEphB4-HSA Before Surgery in Treating Patients With Bladder Cancer, Prostate Cancer, or Kidney Cancer Recruiting NCT02767921 Phase 1
6 Talimogene Laherparepvec in Treating Patients With Non-Muscle Invasive Bladder Transitional Cell Carcinoma Not yet recruiting NCT03430687 Phase 1
7 Quality of Life After Bladder-Preservation Chemotherapy and Radiation Therapy in Patients With Muscle-Invasive Bladder Cancer Recruiting NCT02688348
8 Robot-Assisted Laparoscopic High-Intensity Focused Ultrasound and Radical Cystectomy for Thermal Ablation of Muscle Invasive Cells in Patients With Bladder Tumors Withdrawn NCT03238664
9 Gemcitabine Hydrochloride, Cisplatin, and AGS-003-BLD in Treating Patients With Muscle-Invasive Bladder Cancer Undergoing Surgery Withdrawn NCT02944357 Cisplatin;Gemcitabine Hydrochloride

Search NIH Clinical Center for Invasive Bladder Transitional Cell Carcinoma

Genetic Tests for Invasive Bladder Transitional Cell Carcinoma

Anatomical Context for Invasive Bladder Transitional Cell Carcinoma

MalaCards organs/tissues related to Invasive Bladder Transitional Cell Carcinoma:

38
Endothelial, Prostate, Kidney

Publications for Invasive Bladder Transitional Cell Carcinoma

Articles related to Invasive Bladder Transitional Cell Carcinoma:

# Title Authors Year
1
Overexpression of RING box protein-1 (RBX1) associated with poor prognosis of non-muscle-invasive bladder transitional cell carcinoma. ( 23609182 )
2013
2
Parallel proteomic analysis in muscle-invasive bladder transitional cell carcinoma and cancer-related stroma. ( 23479173 )
2013
3
Detection of specific chromosomal aberrations in urine using BCA-1 (oligo-CGH-array) enhances diagnostic sensitivity and predicts the aggressiveness of non-muscle-invasive bladder transitional cell carcinoma. ( 24196429 )
2013
4
[Expression analysis of NOTCH1/HES1/PTEN signaling pathway in invasive bladder transitional cell carcinoma]. ( 22781569 )
2012
5
Proteomics research on muscle-invasive bladder transitional cell carcinoma. ( 21645413 )
2011
6
Predictive value of cell cycle biomarkers in nonmuscle invasive bladder transitional cell carcinoma. ( 17222615 )
2007
7
Efficacy and tolerability of concurrent weekly low dose cisplatin during radiation treatment of localised muscle invasive bladder transitional cell carcinoma: a report of two sequential Phase II studies from the Trans Tasman Radiation Oncology Group. ( 17011058 )
2006
8
Structural alteration of p53 protein in patients with muscle invasive bladder transitional cell carcinoma. ( 11696726 )
2001

Variations for Invasive Bladder Transitional Cell Carcinoma

Cosmic variations for Invasive Bladder Transitional Cell Carcinoma:

9 (show top 50) (show all 450)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1 COSM5946008 TSC1 urinary tract,bladder,carcinoma,transitional cell carcinoma c.2495C>T p.S832F 10
2 COSM1600408 TSC1 urinary tract,bladder,carcinoma,transitional cell carcinoma c.663+1G>A p.fs*? 10
3 COSM5946010 TSC1 urinary tract,bladder,carcinoma,transitional cell carcinoma c.1579C>G p.Q527E 10
4 COSM5946009 TSC1 urinary tract,bladder,carcinoma,transitional cell carcinoma c.1753C>G p.P585A 10
5 COSM1600406 TSC1 urinary tract,bladder,carcinoma,transitional cell carcinoma c.235T>C p.Y79H 10
6 COSM44225 TP53 urinary tract,bladder,carcinoma,transitional cell carcinoma c.859G>A p.E287K 10
7 COSM10812 TP53 urinary tract,bladder,carcinoma,transitional cell carcinoma c.722C>T p.S241F 10
8 COSM10814 TP53 urinary tract,bladder,carcinoma,transitional cell carcinoma c.832C>G p.P278A 10
9 COSM10660 TP53 urinary tract,bladder,carcinoma,transitional cell carcinoma c.818G>A p.R273H 10
10 COSM43737 TP53 urinary tract,bladder,carcinoma,transitional cell carcinoma c.830G>A p.C277Y 10
11 COSM10687 TP53 urinary tract,bladder,carcinoma,transitional cell carcinoma c.527G>A p.C176Y 10
12 COSM10709 TP53 urinary tract,bladder,carcinoma,transitional cell carcinoma c.722C>G p.S241C 10
13 COSM10728 TP53 urinary tract,bladder,carcinoma,transitional cell carcinoma c.839G>A p.R280K 10
14 COSM10794 TP53 urinary tract,bladder,carcinoma,transitional cell carcinoma c.796G>A p.G266R 10
15 COSM6932 TP53 urinary tract,bladder,carcinoma,transitional cell carcinoma c.733G>A p.G245S 10
16 COSM45261 TP53 urinary tract,bladder,carcinoma,transitional cell carcinoma c.720T>A p.S240R 10
17 COSM10690 TP53 urinary tract,bladder,carcinoma,transitional cell carcinoma c.473G>A p.R158H 10
18 COSM10725 TP53 urinary tract,bladder,carcinoma,transitional cell carcinoma c.701A>G p.Y234C 10
19 COSM10648 TP53 urinary tract,bladder,carcinoma,transitional cell carcinoma c.524G>A p.R175H 10
20 COSM10722 TP53 urinary tract,bladder,carcinoma,transitional cell carcinoma c.853G>A p.E285K 10
21 COSM45289 TP53 urinary tract,bladder,carcinoma,transitional cell carcinoma c.619G>T p.D207Y 10
22 COSM44113 TP53 urinary tract,bladder,carcinoma,transitional cell carcinoma c.693C>T p.T231T 10
23 COSM10724 TP53 urinary tract,bladder,carcinoma,transitional cell carcinoma c.839G>C p.R280T 10
24 COSM44942 TP53 urinary tract,bladder,carcinoma,transitional cell carcinoma c.339C>G p.F113L 10
25 COSM44433 TP53 urinary tract,bladder,carcinoma,transitional cell carcinoma c.872A>C p.K291T 10
26 COSM10779 TP53 urinary tract,bladder,carcinoma,transitional cell carcinoma c.818G>T p.R273L 10
27 COSM10659 TP53 urinary tract,bladder,carcinoma,transitional cell carcinoma c.817C>T p.R273C 10
28 COSM46033 TP53 urinary tract,bladder,carcinoma,transitional cell carcinoma c.427G>C p.V143L 10
29 COSM10656 TP53 urinary tract,bladder,carcinoma,transitional cell carcinoma c.742C>T p.R248W 10
30 COSM11524 TP53 urinary tract,bladder,carcinoma,transitional cell carcinoma c.730G>T p.G244C 10
31 COSM10662 TP53 urinary tract,bladder,carcinoma,transitional cell carcinoma c.743G>A p.R248Q 10
32 COSM11084 TP53 urinary tract,bladder,carcinoma,transitional cell carcinoma c.517G>A p.V173M 10
33 COSM10646 TP53 urinary tract,bladder,carcinoma,transitional cell carcinoma c.725G>A p.C242Y 10
34 COSM44451 TP53 urinary tract,bladder,carcinoma,transitional cell carcinoma c.874A>G p.K292E 10
35 COSM44114 TP53 urinary tract,bladder,carcinoma,transitional cell carcinoma c.826G>A p.A276T 10
36 COSM43687 TP53 urinary tract,bladder,carcinoma,transitional cell carcinoma c.641A>G p.H214R 10
37 COSM10758 TP53 urinary tract,bladder,carcinoma,transitional cell carcinoma c.659A>G p.Y220C 10
38 COSM10705 TP53 urinary tract,bladder,carcinoma,transitional cell carcinoma c.586C>T p.R196* 10
39 COSM10992 TP53 urinary tract,bladder,carcinoma,transitional cell carcinoma c.844C>G p.R282G 10
40 COSM46099 TP53 urinary tract,bladder,carcinoma,transitional cell carcinoma c.269C>T p.S90F 10
41 COSM10704 TP53 urinary tract,bladder,carcinoma,transitional cell carcinoma c.844C>T p.R282W 10
42 COSM10719 TP53 urinary tract,bladder,carcinoma,transitional cell carcinoma c.811G>A p.E271K 10
43 COSM43848 TP53 urinary tract,bladder,carcinoma,transitional cell carcinoma c.472C>T p.R158C 10
44 COSM44190 TP53 urinary tract,bladder,carcinoma,transitional cell carcinoma c.359A>T p.K120M 10
45 COSM43724 TP53 urinary tract,bladder,carcinoma,transitional cell carcinoma c.776A>T p.D259V 10
46 COSM44226 TP53 urinary tract,bladder,carcinoma,transitional cell carcinoma c.380C>T p.S127F 10
47 COSM43965 TP53 urinary tract,bladder,carcinoma,transitional cell carcinoma c.734G>C p.G245A 10
48 COSM43680 TP53 urinary tract,bladder,carcinoma,transitional cell carcinoma c.523C>T p.R175C 10
49 COSM44424 TP53 urinary tract,bladder,carcinoma,transitional cell carcinoma c.590T>A p.V197E 10
50 COSM10891 TP53 urinary tract,bladder,carcinoma,transitional cell carcinoma c.814G>A p.V272M 10

Expression for Invasive Bladder Transitional Cell Carcinoma

Search GEO for disease gene expression data for Invasive Bladder Transitional Cell Carcinoma.

Pathways for Invasive Bladder Transitional Cell Carcinoma

Pathways related to Invasive Bladder Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.4 CDKN1A NOTCH1 TP53
2
Show member pathways
12.15 CDKN1A NOTCH1 TP53
3 12.02 CDKN1A NOTCH1 TP53
4
Show member pathways
11.52 CDKN1A TP53
5 11.49 CDKN1A TP53
6 11.44 CDKN1A NOTCH1
7 11.41 CDKN1A TP53
8 11.36 NOTCH1 TP53
9 11.23 CDKN1A TP53
10 11.22 CDKN1A TP53
11 11.19 CDKN1A TP53
12 11.14 CDKN1A TP53
13 11.08 CDKN1A TP53
14 11 CDKN1A TP53
15 10.83 CDKN1A TP53
16 10.66 CDKN1A TP53 UPK3A
17
Show member pathways
10.6 CDKN1A TP53
18 10.23 CDKN1A TP53
19
Show member pathways
9.86 CDKN1A TP53

GO Terms for Invasive Bladder Transitional Cell Carcinoma

Cellular components related to Invasive Bladder Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum GO:0005783 8.92 NOTCH1 TP53 TPBG UPK3A

Biological processes related to Invasive Bladder Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.74 CDKN1A NOTCH1 TP53
2 Ras protein signal transduction GO:0007265 9.58 CDKN1A TP53
3 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.56 CDKN1A TP53
4 response to UV GO:0009411 9.55 CDKN1A TP53
5 animal organ regeneration GO:0031100 9.54 CDKN1A NOTCH1
6 cellular response to heat GO:0034605 9.52 CDKN1A TP53
7 response to organonitrogen compound GO:0010243 9.51 CDKN1A TP53
8 cellular response to ionizing radiation GO:0071479 9.49 CDKN1A TP53
9 intrinsic apoptotic signaling pathway GO:0097193 9.48 CDKN1A TP53
10 positive regulation of reactive oxygen species metabolic process GO:2000379 9.46 CDKN1A TP53
11 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 9.43 CDKN1A TP53
12 cellular response to gamma radiation GO:0071480 9.4 CDKN1A TP53
13 response to X-ray GO:0010165 9.37 CDKN1A TP53
14 response to hyperoxia GO:0055093 9.32 CDKN1A TP53
15 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.26 CDKN1A TP53
16 replicative senescence GO:0090399 9.16 CDKN1A TP53
17 cell cycle arrest GO:0007050 9.13 CDKN1A NOTCH1 TP53
18 signal transduction by p53 class mediator GO:0072331 8.62 CDKN1A TP53

Sources for Invasive Bladder Transitional Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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