MCID: INV004
MIFTS: 32

Invasive Bladder Transitional Cell Carcinoma malady

Nephrological diseases, Cancer diseases categories

Aliases & Classifications for Invasive Bladder Transitional Cell Carcinoma

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Invasive Bladder Transitional Cell Carcinoma, Aliases & Descriptions:

Name: Invasive Bladder Transitional Cell Carcinoma 9
Infiltrating Bladder Urothelial Carcinoma 60
 
Invasive Bladder Urothelial Carcinoma 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Nephrological diseases


External Ids:

Disease Ontology9 DOID:6477
NCIt38 C27885

Summaries for Invasive Bladder Transitional Cell Carcinoma

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MalaCards based summary: Invasive Bladder Transitional Cell Carcinoma, also known as infiltrating bladder urothelial carcinoma, is related to bladder transitional cell carcinoma and transitional cell carcinoma. An important gene associated with Invasive Bladder Transitional Cell Carcinoma is NOTCH1 (notch 1), and among its related pathways are Notch signaling pathway and Cell cycle Regulation of G1 S transition part 1 . The compounds acnu and 10-hydroxycamptothecin have been mentioned in the context of this disorder. Related mouse phenotypes are craniofacial and tumorigenesis.

Related Diseases for Invasive Bladder Transitional Cell Carcinoma

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Diseases related to Invasive Bladder Transitional Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
idRelated DiseaseScoreTop Affiliating Genes
1bladder transitional cell carcinoma31.5IFI27, TP53
2transitional cell carcinoma31.0IFI27, TP53, CDKN1A
3non-invasive bladder urothelial carcinoma10.6
4laryngeal carcinoma10.2TP53, IFI27
5esophageal cancer10.1IFI27, TP53
6cervical adenocarcinoma10.1IFI27, CDKN1A
7li-fraumeni syndrome10.0CDKN1A, TP53
8thyroid cancer, anaplastic10.0TP53, CDKN1A
9breast cancer10.0NOTCH1, IFI27
10oligodendroglioma10.0TP53, CDKN1A
11ataxia-telangiectasia9.9TP53, CDKN1A
12squamous cell carcinoma, head and neck9.9CDKN1A, TP53
13laryngeal squamous cell carcinoma9.9CDKN1A, IFI27, TP53
14thyroid cancer9.9TP53, CDKN1A
15papilloma9.9CDKN1A, IFI27, TP53
16oral cancer9.9IFI27, CDKN1A, TP53
17b-cell lymphomas9.9CDKN1A, TP53, IFI27
18endometrial cancer9.8IFI27, CDKN1A, TP53
19stomach cancer9.8TP53, IFI27, CDKN1A
20bladder cancer, somatic9.8CDKN1A, TP53
21astrocytoma9.8TP53, IFI27, CDKN1A
22retinoblastoma9.8CDKN1A, TP53, IFI27
23ovarian cancer, somatic9.8IFI27, CDKN1A, TP53
24glioblastoma9.8IFI27, CDKN1A, TP53
25lung cancer9.8IFI27, TP53, CDKN1A
26adenoma9.8CDKN1A, TP53, IFI27
27myeloma9.8CDKN1A, IFI27, NOTCH1
28malignant glioma9.8NOTCH1, CDKN1A, TP53
29gastric cancer, somatic9.8TP53, IFI27, CDKN1A
30brain cancer9.8NOTCH1, TP53, CDKN1A
31osteosarcoma, somatic9.7CDKN1A, NOTCH1, TP53
32glioblastoma multiforme9.7CDKN1A, TP53
33colorectal cancer9.7CDKN1A, IFI27, TP53
34cervical cancer, somatic9.6NOTCH1, IFI27, TP53, CDKN1A
35pancreatic cancer9.6TP53, IFI27, NOTCH1, CDKN1A
36burkitt lymphoma9.6NOTCH1, CDKN1A, IFI27, TP53
37hepatocellular carcinoma9.6CDKN1A, IFI27, NOTCH1, TP53
38tongue squamous cell carcinoma9.6NOTCH1, TP53, CDKN1A, IFI27
39adenocarcinoma9.6CDKN1A, IFI27, TP53, NOTCH1
40melanoma9.6TP53, NOTCH1, CDKN1A, IFI27
41prostate cancer9.6TP53, NOTCH1, CDKN1A, IFI27
42leukemia9.6TP53, IFI27, NOTCH1, CDKN1A

Graphical network of the top 20 diseases related to Invasive Bladder Transitional Cell Carcinoma:



Diseases related to invasive bladder transitional cell carcinoma

Symptoms for Invasive Bladder Transitional Cell Carcinoma

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Drugs & Therapeutics for Invasive Bladder Transitional Cell Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Invasive Bladder Transitional Cell Carcinoma

Search NIH Clinical Center for Invasive Bladder Transitional Cell Carcinoma

Genetic Tests for Invasive Bladder Transitional Cell Carcinoma

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Anatomical Context for Invasive Bladder Transitional Cell Carcinoma

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Animal Models for Invasive Bladder Transitional Cell Carcinoma or affiliated genes

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MGI Mouse Phenotypes related to Invasive Bladder Transitional Cell Carcinoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053828.9CDKN1A, NOTCH1, TP53
2MP:00020068.8CDKN1A, NOTCH1, TP53
3MP:00053808.4CDKN1A, RBX1, NOTCH1, TP53
4MP:00053848.1TP53, NOTCH1, RBX1, CDKN1A

Publications for Invasive Bladder Transitional Cell Carcinoma

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Articles related to Invasive Bladder Transitional Cell Carcinoma:

idTitleAuthorsYear
1
Detection of specific chromosomal aberrations in urine using BCA-1 (oligo-CGH-array) enhances diagnostic sensitivity and predicts the aggressiveness of non-muscle-invasive bladder transitional cell carcinoma. (24196429)
2013
2
Parallel proteomic analysis in muscle-invasive bladder transitional cell carcinoma and cancer-related stroma. (23479173)
2013
3
Overexpression of RING box protein-1 (RBX1) associated with poor prognosis of non-muscle-invasive bladder transitional cell carcinoma. (23609182)
2013
4
Expression analysis of NOTCH1/HES1/PTEN signaling pathway in invasive bladder transitional cell carcinoma]. (22781569)
2012
5
Proteomics research on muscle-invasive bladder transitional cell carcinoma. (21645413)
2011
6
Predictive value of cell cycle biomarkers in nonmuscle invasive bladder transitional cell carcinoma. (17222615)
2007
7
Efficacy and tolerability of concurrent weekly low dose cisplatin during radiation treatment of localised muscle invasive bladder transitional cell carcinoma: a report of two sequential Phase II studies from the Trans Tasman Radiation Oncology Group. (17011058)
2006
8
Structural alteration of p53 protein in patients with muscle invasive bladder transitional cell carcinoma. (11696726)
2001

Variations for Invasive Bladder Transitional Cell Carcinoma

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Cosmic variations for Invasive Bladder Transitional Cell Carcinoma:

7
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Conf
110731TP53urinary tract,bladder,carcinoma,transitional cell carcinoma2

Expression for genes affiliated with Invasive Bladder Transitional Cell Carcinoma

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Search GEO for disease gene expression data for Invasive Bladder Transitional Cell Carcinoma.

Pathways for genes affiliated with Invasive Bladder Transitional Cell Carcinoma

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Pathways related to Invasive Bladder Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 45)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Notch signaling pathway36
9.5NOTCH1, CDKN1A
2
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation58
9.4CDKN1A, RBX1
39.4CDKN1A, RBX1
4
Show member pathways
Cell cycle ESR1 regulation of G1 S transition58
Immune response MIF JAB1 signaling58
Cell cycle Cell cycle generic schema 58
9.4CDKN1A, RBX1
59.4NOTCH1, TP53
6
Show member pathways
9.4NOTCH1, TP53
79.3TP53, CDKN1A
8
Show member pathways
9.3CDKN1A, TP53
99.3TP53, CDKN1A
109.3CDKN1A, TP53
11
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways58
9.3TP53, CDKN1A
129.3TP53, CDKN1A
13
Show member pathways
9.3TP53, CDKN1A
14
Show member pathways
DNA damage response36
9.3CDKN1A, TP53
15
Show member pathways
Development IGF RI signaling
Immune response IL 4 signaling pathway58
Signal transduction AKT signaling58
9.3CDKN1A, TP53
169.3CDKN1A, TP53
179.3CDKN1A, TP53
18
Show member pathways
9.3CDKN1A, TP53
199.3TP53, CDKN1A
20
Show member pathways
Signal transduction PTEN pathway58
9.3CDKN1A, TP53
21
Show member pathways
ErbB receptor signaling network36
ErbB signaling pathway36
9.3CDKN1A, TP53
22
Show member pathways
9.3TP53, CDKN1A
239.3TP53, CDKN1A
249.3CDKN1A, TP53
259.3CDKN1A, TP53
269.3CDKN1A, TP53
279.3CDKN1A, TP53
28
Show member pathways
ATM Signaling Pathway36
9.3TP53, CDKN1A
299.3CDKN1A, TP53
309.3CDKN1A, TP53
31
Show member pathways
9.3CDKN1A, TP53
32
Show member pathways
9.3TP53, CDKN1A
339.3RBX1, TP53
349.3RBX1, TP53
358.9CDKN1A, NOTCH1, TP53
36
Show member pathways
8.9CDKN1A, NOTCH1, TP53
37
Show member pathways
Delta-Notch Signaling Pathway36
Notch Signaling Pathway36
8.9RBX1, NOTCH1, TP53
38
Show member pathways
8.9TP53, NOTCH1, RBX1
39
Show member pathways
8.8CDKN1A, RBX1, TP53
40
Show member pathways
Proteasome Degradation36
Immune response Antigen presentation by MHC class I58
8.8CDKN1A, RBX1, TP53
41
Show member pathways
Cell cycle36
8.8CDKN1A, RBX1, TP53
428.8TP53, RBX1, CDKN1A
438.8TP53, RBX1, CDKN1A
44
Show member pathways
8.4TP53, NOTCH1, RBX1, CDKN1A

Compounds for genes affiliated with Invasive Bladder Transitional Cell Carcinoma

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Compounds related to Invasive Bladder Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 72)
idCompoundScoreTop Affiliating Genes
1acnu439.8TP53, CDKN1A
210-hydroxycamptothecin439.7CDKN1A, TP53
37-hydroxystaurosporine43 1210.7TP53, CDKN1A
4tomudex439.7TP53, CDKN1A
5hpvs439.7CDKN1A, TP53
63,3-diindolylmethane439.7CDKN1A, TP53
7olomoucine43 1210.7CDKN1A, TP53
8temozolomide43 1210.7CDKN1A, TP53
9taxane439.7TP53, CDKN1A
10noxa439.6CDKN1A, TP53
11cd 437439.6CDKN1A, TP53
12aphidicolin439.6CDKN1A, TP53
13p00048439.6IFI27, CDKN1A
14optimax439.6IFI27, CDKN1A
15depsipeptide439.6CDKN1A, TP53
16mevastatin43 28 1211.5IFI27, CDKN1A
17methylmethanesulfonate439.5CDKN1A, TP53
18suberoylanilide hydroxamic acid439.5TP53, CDKN1A
19n-(4-hydroxyphenyl)retinamide439.5CDKN1A, TP53
20eb 108943 5910.5CDKN1A, IFI27
212-methoxyestradiol43 59 2411.4CDKN1A, TP53
22benzo(a)pyrene439.4CDKN1A, TP53
23leptomycin b43 5910.3TP53, CDKN1A
24oxaliplatin43 49 1211.2CDKN1A, TP53
25flavopiridol43 1210.0CDKN1A, TP53
26rapamycin439.0CDKN1A, NOTCH1, IFI27
27hmba439.0CDKN1A, IFI27, TP53
28indole-3-carbinol439.0CDKN1A, IFI27, TP53
29sulindac43 1210.0TP53, IFI27, CDKN1A
30roscovitine439.0CDKN1A, IFI27, TP53
31genistein43 28 59 2 24 1213.9CDKN1A, NOTCH1, IFI27
32adpribose438.9CDKN1A, IFI27, TP53
33thymidylate438.9CDKN1A, IFI27, TP53
34cytarabine43 49 1210.9TP53, IFI27, CDKN1A
35resveratrol43 59 24 1211.9CDKN1A, IFI27, TP53
36mg 13243 599.9CDKN1A, IFI27, TP53
37retinoid438.9TP53, IFI27, CDKN1A
38n acetylcysteine438.9CDKN1A, IFI27, TP53
39butyrate438.9TP53, IFI27, CDKN1A
40tamoxifen43 49 28 1211.9CDKN1A, IFI27, TP53
41paclitaxel43 49 1210.9TP53, IFI27, CDKN1A
42paraffin438.8TP53, IFI27, CDKN1A
43thymidine43 249.8TP53, IFI27, CDKN1A
44cisplatin43 49 59 1211.8CDKN1A, IFI27, TP53
45progesterone43 28 59 24 1212.5CDKN1A, IFI27, TP53
46ly294002438.5CDKN1A, NOTCH1, IFI27, TP53
47doxorubicin43 49 1210.5TP53, IFI27, NOTCH1, CDKN1A
48vegf438.5CDKN1A, NOTCH1, IFI27, TP53
49estrogen438.5CDKN1A, NOTCH1, IFI27, TP53
50retinoic acid43 249.4CDKN1A, NOTCH1, IFI27, TP53

GO Terms for genes affiliated with Invasive Bladder Transitional Cell Carcinoma

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Cellular components related to Invasive Bladder Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:00058298.4CDKN1A, RBX1, NOTCH1, TP53
2nucleoplasmGO:00056548.1CDKN1A, RBX1, NOTCH1, TP53

Biological processes related to Invasive Bladder Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1mitotic cell cycle arrestGO:00718509.6CDKN1A, TP53
2cellular response to ionizing radiationGO:00714799.6TP53, CDKN1A
3positive regulation of reactive oxygen species metabolic processGO:020003799.5CDKN1A, TP53
4intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGO:00427719.5CDKN1A, TP53
5intrinsic apoptotic signaling pathwayGO:00971939.4CDKN1A, TP53
6DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:00069779.4CDKN1A, TP53
7Ras protein signal transductionGO:00072659.3TP53, CDKN1A
8cell cycle arrestGO:00070509.3CDKN1A, TP53
9cellular response to hypoxiaGO:00714569.2RBX1, TP53
10Notch signaling pathwayGO:00072199.1RBX1, NOTCH1, TP53
11negative regulation of cell growthGO:00303089.0CDKN1A, TP53
12negative regulation of cell proliferationGO:00082859.0TP53, NOTCH1, CDKN1A

Products for genes affiliated with Invasive Bladder Transitional Cell Carcinoma

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Sources for Invasive Bladder Transitional Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet