MCID: INV004
MIFTS: 38

Invasive Bladder Transitional Cell Carcinoma malady

Summaries for Invasive Bladder Transitional Cell Carcinoma

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33MalaCards
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MalaCards: Invasive Bladder Transitional Cell Carcinoma, also known as infiltrating bladder urothelial carcinoma, is related to bladder transitional cell carcinoma and bladder carcinoma. An important gene associated with Invasive Bladder Transitional Cell Carcinoma is CDKN1A (cyclin-dependent kinase inhibitor 1A (p21, Cip1)), and among its related pathways are Colorectal Cancer Metastasis and Signaling events mediated by HDAC Class III. The compounds resveratrol and Afatinib have been mentioned in the context of this disorder. Related mouse phenotypes are embryogenesis and skeleton.

Aliases & Classifications for Invasive Bladder Transitional Cell Carcinoma

Sources:
8Disease Ontology, 61UMLS, 40NCIt
See all sources

Aliases & Descriptions:

invasive bladder transitional cell carcinoma 8
infiltrating bladder urothelial carcinoma 61
invasive bladder urothelial carcinoma 8


External Ids:

Disease Ontology8 DOID:6477
NCIt40 C27885

Related Diseases for Invasive Bladder Transitional Cell Carcinoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Invasive Bladder Transitional Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 94)
idRelated DiseaseScoreTop Affiliating Genes
1bladder transitional cell carcinoma31.1IFI27, TP53
2bladder carcinoma31.1TP53, ERBB2, CDKN1A
3transitional cell carcinoma31.1TP53, ERBB2, CDKN1A, EGFR, IFI27
4infiltrating bladder urothelial carcinoma sarcomatoid variant10.7
5lipid-cell variant infiltrating bladder urothelial carcinoma10.5
6plasmacytoid variant infiltrating bladder urothelial carcinoma10.5
7nested variant infiltrating bladder urothelial carcinoma10.5
8lymphoma-like variant infiltrating bladder urothelial carcinoma10.5
9microcystic variant infiltrating bladder urothelial carcinoma10.5
10clear cell variant infiltrating bladder urothelial carcinoma10.5
11micropapillary variant infiltrating bladder urothelial carcinoma10.5
12non-invasive bladder urothelial carcinoma10.4
13gastrointestinal stromal tumor10.0IFI27
14leukoplakia10.0IFI27
15cervical intraepithelial neoplasia10.0IFI27
16tongue cancer10.0CDKN1A
17thymoma10.0IFI27
18pituitary tumors10.0IFI27
19colon adenocarcinoma10.0CDKN1A
20smooth muscle tumor10.0IFI27
21pituitary adenoma10.0IFI27
22uterine carcinosarcoma10.0ERBB2
23cervical squamous cell carcinoma10.0CDKN1A
24multiple myeloma10.0TP53
25myeloid leukemia10.0CDKN1A
26oral cavity cancer10.0TP53
27sarcoma10.0TP53
28neuroblastoma10.0TP53
29wilms tumor10.0NOTCH1
30nephroblastoma10.0TP53
31rhabdomyosarcoma10.0TP53
32ependymoma10.0EGFR
33gallbladder cancer10.0TP53
34acute leukemia10.0NOTCH1
35familial adenomatous polyposis10.0TP53
36skin cancer10.0TP53
37giant cell glioblastoma10.0EGFR
38cervical adenocarcinoma10.0IFI27, CDKN1A
39benign mesothelioma10.0TP53
40nasopharynx carcinoma10.0TP53
41gastritis10.0TP53
42fibrosarcoma10.0CDKN1A
43anaplastic oligodendroglioma10.0EGFR
44thyroid cancer10.0TP53, CDKN1A
45medulloblastoma10.0TP53, ERBB2
46keratoacanthoma10.0CDKN1A
47alzheimer's disease10.0NOTCH1
48li-fraumeni syndrome10.0TP53, CDKN1A
49malignant mixed mullerian tumor10.0TP53, ERBB2
50biliary tract cancer10.0EGFR, ERBB2

Graphical network of the top 20 diseases related to Invasive Bladder Transitional Cell Carcinoma:



Diseases related to invasive bladder transitional cell carcinoma

Clinical Features for Invasive Bladder Transitional Cell Carcinoma

Drugs & Therapeutics for Invasive Bladder Transitional Cell Carcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Invasive Bladder Transitional Cell Carcinoma

Drug clinical trials:

Search ClinicalTrials for Invasive Bladder Transitional Cell Carcinoma

Search NIH Clinical Center for Invasive Bladder Transitional Cell Carcinoma

Search CenterWatch for Invasive Bladder Transitional Cell Carcinoma

Genetic Tests for Invasive Bladder Transitional Cell Carcinoma

Anatomical Context for Invasive Bladder Transitional Cell Carcinoma

Animal Models for Invasive Bladder Transitional Cell Carcinoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Invasive Bladder Transitional Cell Carcinoma

Sources:
51PubMed
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Articles related to Invasive Bladder Transitional Cell Carcinoma:

(show all 47)
idTitleAuthorsYear
1
Detection of specific chromosomal aberrations in urine using BCA-1 (oligo-CGH-array) enhances diagnostic sensitivity and predicts the aggressiveness of non-muscle-invasive bladder transitional cell carcinoma. (24196429)
2013
2
Induction of invasive transitional cell bladder carcinoma in immune intact human MUC1 transgenic mice: a model for immunotherapy development. (24300078)
2013
3
Downregulation of CDH13 expression promotes invasiveness of bladder transitional cell carcinoma. (23235385)
2013
4
Parallel proteomic analysis in muscle-invasive bladder transitional cell carcinoma and cancer-related stroma. (23479173)
2013
5
Overexpression of RING box protein-1 (RBX1) associated with poor prognosis of non-muscle-invasive bladder transitional cell carcinoma. (23609182)
2013
6
A case of unusual mast cell response with interstitial cystitis-like symptoms to neoadjuvant chemotherapy for muscle-invasive transitional cell carcinoma of the bladder. (24335680)
2013
7
Non-muscle invasive transitional cell carcinoma of the distal ureter and bladder with lung metastasis: A case report and literature review. (23500737)
2013
8
Dynamic contrast-enhanced MRI in patients with muscle-invasive transitional cell carcinoma of the bladder can distinguish between residual tumour and post-chemotherapy effect. (24034835)
2013
9
Collateral activity of immunotherapy with bacillus Calmette-GuAcrin for the treatment of non-muscle-invasive transitional cell carcinoma of the bladder: new insights. (23219084)
2013
10
Accelerated methotrexate, vinblastine, doxorubicin, and cisplatin (AMVAC) as neoadjuvant chemotherapy for patients with muscle-invasive transitional cell carcinoma of the bladder. (22614698)
2012
11
Expression analysis of NOTCH1/HES1/PTEN signaling pathway in invasive bladder transitional cell carcinoma]. (22781569)
2012
12
Proteomics research on muscle-invasive bladder transitional cell carcinoma. (21645413)
2011
13
A rare and unusual case of isolated cerebellar metastasis from a non-muscle invasive transitional cell carcinoma of bladder. (21731820)
2011
14
Superficially invasive transitional cell carcinoma of the bladder associated with distant cutaneous metastases. (19919656)
2010
15
Gli2 expression and human bladder transitional carcinoma cell invasiveness. (20488474)
2010
16
Effects of short-term celecoxib treatment in patients with invasive transitional cell carcinoma of the urinary bladder. (20423998)
2010
17
Potential of molecular targeted therapy of HER-2 and Cox-2 for invasive transitional cell carcinoma of the urinary bladder. (20428812)
2010
18
Lipid profiles of canine invasive transitional cell carcinoma of the urinary bladder and adjacent normal tissue by desorption electrospray ionization imaging mass spectrometry. (19810710)
2009
19
Single postoperative instillation of gemcitabine in patients with non-muscle-invasive transitional cell carcinoma of the bladder: a randomised, double-blind, placebo-controlled phase III multicentre study. (19560257)
2009
20
Canine invasive transitional cell carcinoma cell lines: in vitro tools to complement a relevant animal model of invasive urinary bladder cancer. (18562222)
2009
21
Cyclooxygenase-2 expression in invasive transitional cell carcinoma of the urinary bladder. (21479487)
2008
22
Results of the phase II EORTC 22971 trial evaluating combined accelerated external radiation and chemotherapy with 5FU and cisplatin in patients with muscle invasive transitional cell carcinoma of the bladder. (18568488)
2008
23
Management of early-invasive high-grade transitional cell carcinoma of the bladder. (18923363)
2008
24
High incidence of lung cancer after non-muscle-invasive transitional cell carcinoma of the bladder: implications for screening trials. (18501097)
2008
25
Follow-up of nonmuscle invasive transitional cell carcinoma of the bladder: how and how often? (18670275)
2008
26
Why consider neoadjuvant chemotherapy for muscle-invasive transitional cell carcinoma of the bladder? (18682771)
2008
27
Predictive value of cell cycle biomarkers in nonmuscle invasive bladder transitional cell carcinoma. (17222615)
2007
28
Transurethral Resection of Bladder Tumor (TUR-BT) then Concomitant Radiation and Cisplatin Followed by Adjuvant Gemcitabine and Cisplatin in Muscle Invasive Transitional Cell Carcinoma (TCC) of the Urinary Bladder. (18839038)
2007
29
Efficacy and tolerability of concurrent weekly low dose cisplatin during radiation treatment of localised muscle invasive bladder transitional cell carcinoma: a report of two sequential Phase II studies from the Trans Tasman Radiation Oncology Group. (17011058)
2006
30
Novel approach of human epidermal growth factor receptor 2 detection in noninvasive and invasive transitional cell carcinoma of the bladder. (16469569)
2006
31
Combined determination of plasma MMP2, MMP9, and TIMP1 improves the non-invasive detection of transitional cell carcinoma of the bladder. (16901349)
2006
32
E-cadherin immunoreactivity correlates with recurrence and progression of minimally invasive transitional cell carcinomas of the urinary bladder. (16142373)
2005
33
Prognostic significance of insulin-like growth factor (IGF) binding protein-2 to IGF-binding protein-3 ratio in patients undergoing radical cystectomy for invasive transitional cell carcinoma of the bladder. (15839919)
2005
34
Expression of the tumor suppressor protein 14-3-3 sigma is down-regulated in invasive transitional cell carcinomas of the urinary bladder undergoing epithelial-to-mesenchymal transition. (14736829)
2004
35
HER2/neu overexpression in the development of muscle-invasive transitional cell carcinoma of the bladder. (14520464)
2003
36
Prediction of lymph node metastasis based on p53 and nm23-H1 expression in muscle invasive grade III transitional cell carcinoma of bladder. (15088897)
2003
37
Organ-sparing treatment of invasive transitional cell bladder carcinoma. (17918795)
2002
38
Structural alteration of p53 protein in patients with muscle invasive bladder transitional cell carcinoma. (11696726)
2001
39
Differential expression of progression-related genes in the evolution of superficial to invasive transitional cell carcinoma of the bladder. (11115562)
2001
40
Relation between cyclooxygenase-2 expression and tumor invasiveness and patient survival in transitional cell carcinoma of the urinary bladder. (11443626)
2001
41
Highly invasive transitional cell carcinoma of the bladder in a simian virus 40 T-antigen transgenic mouse model. (10980120)
2000
42
Molecular evolution and intratumor heterogeneity by topographic compartments in muscle-invasive transitional cell carcinoma of the urinary bladder. (10744064)
2000
43
G1 checkpoint protein and p53 abnormalities occur in most invasive transitional cell carcinomas of the urinary bladder. (10376969)
1999
44
Expression of cyclooxygenase-2 (COX-2) in human invasive transitional cell carcinoma (TCC) of the urinary bladder. (10582676)
1999
45
PTCH gene mutations in invasive transitional cell carcinoma of the bladder. (9764827)
1998
46
Relationship of p53 and bcl-2 to prognosis in muscle-invasive transitional cell carcinoma of the bladder. (8627878)
1996
47
Expression of epidermal growth factor receptor in invasive transitional cell carcinoma of the urinary bladder. A multivariate survival analysis. (7906919)
1994

Genetic Variations for Invasive Bladder Transitional Cell Carcinoma

Expression for genes affiliated with Invasive Bladder Transitional Cell Carcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Invasive Bladder Transitional Cell Carcinoma

Search GEO for disease gene expression data for Invasive Bladder Transitional Cell Carcinoma.

Pathways for genes affiliated with Invasive Bladder Transitional Cell Carcinoma

Sources:
52QIAGEN, 38NCBI BioSystems Database, 12EMD Millipore, 30KEGG, 60Tocris Bioscience, 54Reactome, 56SinoBiological, 50PharmGKB, 53R&D Systems
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Pathways related to Invasive Bladder Transitional Cell Carcinoma according to GeneCards/GeneDecks:

(show all 49)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0EGFR
29.6TP53, CDKN1A
39.6TP53, CDKN1A
49.6TP53, CDKN1A
59.6TP53, CDKN1A
69.6CDKN1A, TP53
7
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9.6CDKN1A, TP53
89.6CDKN1A, TP53
9
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9.6TP53, ERBB2
10
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9.6TP53, ERBB2
119.6CDKN1A, EGFR
129.6RBX1, CDKN1A
13
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9.5ERBB2, EGFR
149.5EGFR, ERBB2
159.5EGFR, ERBB2
169.5TP53, EGFR
179.5TP53, RBX1
189.3NOTCH1, EGFR
199.3RBX1, NOTCH1
20
Hide members
9.2CDKN1A, ERBB2, TP53
21
Transcription Androgen Receptor nuclear signaling
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9.2EGFR, CDKN1A, ERBB2
22
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9.2ERBB2, CDKN1A, EGFR
239.2ERBB2, CDKN1A, EGFR
24
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9.2EGFR, CDKN1A, ERBB2
259.1TP53, CDKN1A, EGFR
269.1TP53, CDKN1A, EGFR
279.1EGFR, CDKN1A, TP53
289.1TP53, CDKN1A, EGFR
29
Hide members
9.1TP53, CDKN1A, RBX1
309.1TP53, ERBB2, EGFR
319.0ERBB2, EGFR, RBX1
32
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8.8IFI27, RBX1, CDKN1A
33
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8.7EGFR, CDKN1A, ERBB2, TP53
34
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8.7EGFR, CDKN1A, ERBB2, TP53
35
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8.7TP53, ERBB2, CDKN1A, EGFR
368.7TP53, ERBB2, CDKN1A, EGFR
378.7EGFR, CDKN1A, ERBB2, TP53
38
Hide members
8.7TP53, ERBB2, CDKN1A, EGFR
398.7TP53, ERBB2, CDKN1A, EGFR
40
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8.7EGFR, CDKN1A, ERBB2, TP53
41
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8.6ERBB2, CDKN1A, EGFR, RBX1
42
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8.6RBX1, EGFR, ERBB2, TP53
43
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8.6RBX1, EGFR, ERBB2, TP53
44
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8.4RBX1, EGFR, NOTCH1, TP53
458.2RBX1, EGFR, CDKN1A, ERBB2, TP53
468.1EGFR, CDKN1A, NOTCH1, ERBB2, TP53
47
Hide members
8.1EGFR, CDKN1A, NOTCH1, ERBB2, TP53
48
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8.0RBX1, EGFR, CDKN1A, NOTCH1, ERBB2
498.0ERBB2, NOTCH1, CDKN1A, EGFR, RBX1

Compounds for genes affiliated with Invasive Bladder Transitional Cell Carcinoma

Sources:
45Novoseek, 60Tocris Bioscience, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR, 2BitterDB
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Compounds related to Invasive Bladder Transitional Cell Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 100)
idCompoundScoreTop Affiliating Genes
1resveratrol45 60 11 2413.5ERBB2
2Afatinib119.8ERBB2, EGFR
3iressa609.8EGFR, ERBB2
4pd158780459.8EGFR, ERBB2
5ag 1478 hydrochloride609.7ERBB2, EGFR
6ag 490609.7EGFR, ERBB2
7jnj 28871063 hydrochloride609.7ERBB2, EGFR
8hrgbeta1459.6CDKN1A, EGFR, ERBB2
9optimax459.6IFI27, CDKN1A
10p00048459.6CDKN1A, IFI27
11n-(4-hydroxyphenyl)retinamide459.5TP53, ERBB2, CDKN1A
12pki-166459.5ERBB2, EGFR
13temozolomide45 1110.5TP53, CDKN1A, EGFR
14pertuzumab45 50 1111.4EGFR, ERBB2
15topotecan45 1110.4TP53, ERBB2, EGFR
16celecoxib45 60 29 50 11 2414.3EGFR, ERBB2, CDKN1A
17indole-3-carbinol459.2IFI27, CDKN1A, TP53
18taxane459.2TP53, ERBB2, EGFR, CDKN1A
19sulindac45 1110.2TP53, CDKN1A, IFI27
20suberoylanilide hydroxamic acid459.2ERBB2, CDKN1A, EGFR, TP53
21oxaliplatin45 50 1111.2TP53, CDKN1A, EGFR, ERBB2
22flavopiridol45 1110.2CDKN1A, TP53, ERBB2, EGFR
23bortezomib45 1110.1CDKN1A, ERBB2, TP53, EGFR
24irinotecan45 50 1111.1EGFR, CDKN1A, TP53, ERBB2
25geldanamycin45 50 60 1112.1ERBB2, TP53, CDKN1A, EGFR
26gemcitabine45 50 1111.1EGFR, CDKN1A, ERBB2, TP53
27roscovitine459.1CDKN1A, TP53, IFI27
28docetaxel45 50 60 1112.1TP53, EGFR, CDKN1A, ERBB2
29carboplatin45 50 1111.1TP53, ERBB2, EGFR
30curcumin459.1TP53, EGFR, ERBB2, CDKN1A
315fluorouracil459.1EGFR, TP53, ERBB2, CDKN1A
32trastuzumab45 50 1111.0ERBB2, EGFR, IFI27
33gefitinib45 50 1110.8CDKN1A, ERBB2, IFI27, EGFR
34adpribose458.7IFI27, CDKN1A, TP53, EGFR
35mg 13245 609.7IFI27, CDKN1A, TP53, EGFR
36retinoid458.6IFI27, EGFR, TP53, CDKN1A
37tetracycline45 119.4IFI27, ERBB2, EGFR
38thymidylate458.3CDKN1A, EGFR, IFI27, ERBB2, TP53
39n acetylcysteine458.3ERBB2, CDKN1A, EGFR, IFI27, TP53
40tamoxifen45 50 29 1111.3TP53, IFI27, EGFR, ERBB2, CDKN1A
41paclitaxel45 50 1110.3ERBB2, EGFR, IFI27, TP53, CDKN1A
42paraffin458.3ERBB2, TP53, CDKN1A, EGFR, IFI27
43cisplatin45 50 60 1111.3TP53, CDKN1A, ERBB2, IFI27, EGFR
44progesterone45 60 29 11 2412.2TP53, IFI27, ERBB2, CDKN1A, EGFR
45rapamycin458.1ERBB2, NOTCH1, EGFR, CDKN1A, IFI27
46genistein45 29 60 2 11 2413.1NOTCH1, EGFR, CDKN1A, IFI27, ERBB2
47retinoic acid45 248.7TP53, IFI27, EGFR, CDKN1A, NOTCH1
48ly294002457.7CDKN1A, ERBB2, EGFR, NOTCH1, IFI27, TP53
49doxorubicin45 50 119.7IFI27, EGFR, CDKN1A, ERBB2, TP53, NOTCH1
50vegf457.7IFI27, EGFR, CDKN1A, NOTCH1, ERBB2, TP53

GO Terms for genes affiliated with Invasive Bladder Transitional Cell Carcinoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Invasive Bladder Transitional Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:0056548.5TP53, NOTCH1, CDKN1A, RBX1

Biological processes related to Invasive Bladder Transitional Cell Carcinoma according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1mitotic cell cycle arrestGO:0718509.9TP53, CDKN1A
2cellular response to ionizing radiationGO:0714799.8CDKN1A, TP53
3positive regulation of reactive oxygen species metabolic processGO:20003799.8TP53, CDKN1A
4positive regulation of fibroblast proliferationGO:0481469.6CDKN1A, EGFR
5positive regulation of MAP kinase activityGO:0434069.4EGFR, ERBB2
6phosphatidylinositol-mediated signalingGO:0480159.4ERBB2, CDKN1A, EGFR
7fibroblast growth factor receptor signaling pathwayGO:0085439.4EGFR, CDKN1A, ERBB2
8Fc-epsilon receptor signaling pathwayGO:0380959.4ERBB2, CDKN1A, EGFR
9epidermal growth factor receptor signaling pathwayGO:0071739.3ERBB2, CDKN1A, EGFR
10neurotrophin TRK receptor signaling pathwayGO:0480119.2ERBB2, CDKN1A, EGFR
11positive regulation of epithelial cell proliferationGO:0506799.2ERBB2, NOTCH1, EGFR
12negative regulation of cell proliferationGO:0082859.0TP53, NOTCH1, CDKN1A
13cell proliferationGO:0082838.8TP53, ERBB2, EGFR

Molecular functions related to Invasive Bladder Transitional Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1epidermal growth factor-activated receptor activityGO:0050069.6ERBB2, EGFR
2receptor signaling protein tyrosine kinase activityGO:0047169.5ERBB2, EGFR
3transmembrane receptor protein tyrosine kinase activityGO:0047149.2ERBB2, EGFR
4protein heterodimerization activityGO:0469829.1TP53, ERBB2, EGFR
5enzyme bindingGO:0198998.8EGFR, NOTCH1, TP53

Products for genes affiliated with Invasive Bladder Transitional Cell Carcinoma

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Sources for Invasive Bladder Transitional Cell Carcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet