MCID: INV006
MIFTS: 52

Inverted Papilloma malady

Summaries for Inverted Papilloma

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63Wikipedia, 32MalaCards
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Wikipedia:63 An inverted papilloma is a type of tumor in which surface epithelial cells grow downward into the... more...

MalaCards: Inverted Papilloma, also known as inverted papilloma, squamous cell, is related to papilloma and squamous cell carcinoma. An important gene associated with Inverted Papilloma is KRT13 (keratin 13), and among its related pathways are Senescence and Autophagy and Cytoskeletal Signaling. The compounds butyrate and mucicarmine have been mentioned in the context of this disorder. Affiliated tissues include bone, prostate and cervix, and related mouse phenotypes are endocrine/exocrine gland and digestive/alimentary.

Aliases & Classifications for Inverted Papilloma

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8Disease Ontology, 10DISEASES, 60UMLS, 44Novoseek, 39NCIt, 34MeSH
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Aliases & Descriptions:

inverted papilloma 8 10 60
inverted papilloma, squamous cell 8
papilloma inverted 44


External Ids:

Disease Ontology8 DOID:3179
NCIt39 C3793
MeSH34 D018308

Related Diseases for Inverted Papilloma

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17GeneCards, 18GeneDecks
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Diseases related to Inverted Papilloma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 184)
idRelated DiseaseScoreTop Affiliating Genes
1papilloma32.1IFI27, CDKN2A, CDKN1A, PCNA, FGFR3, FSCN1
2squamous cell carcinoma31.1FSCN1, KRT7, KRT20, KRT13, ACTC1, SERPINB3
3transitional cell carcinoma30.9IFI27, TOP2A, MKI67, CDKN1A, PCNA, FGFR3
4bladder carcinoma30.8IFI27, TOP2A, MKI67, CDKN2A, CDKN1A, PCNA
5bladder transitional cell papilloma30.8FGFR3
6bladder transitional cell carcinoma30.7KRT20, MKI67, IFI27
7papillary carcinoma30.6IFI27, MKI67, KRT7, KRT20, ACTC1
8adenocarcinoma30.5KRT13, ACTC1, SERPINB3, KRT20, KRT7, FSCN1
9colon adenocarcinoma30.1KRT20, CDKN1A
10leiomyoma30.1ACTC1, PCNA, MKI67
11sarcoma30.1TOP2A, MKI67, FSCN1, ACTC1
12synovial sarcoma30.1KRT13, KRT7, MKI67
13bladder carcinoma in situ30.1CDKN2A, PCNA, FGFR3, KRT20, SERPINB3
14melanoma30.1MKI67, TOP2A, PPARD, FOXP3, IFI27, CDKN2A
15urinary bladder inverted papilloma10.8
16ureter inverted papilloma10.8
17squamous cell papilloma10.8
18nasal cavity inverting papilloma10.8
19frontal sinus inverted papilloma10.7
20sphenoid sinus inverted papilloma10.7
21maxillary sinus inverted papilloma10.7
22renal pelvis inverted papilloma10.6
23inverted transitional papilloma10.6
24transitional papilloma10.6
25urethra inverted papilloma10.6
26ethmoid sinus inverted papilloma10.4
27papillary transitional carcinoma10.4
28verrucous carcinoma10.3
29verrucous papilloma10.3
30in situ carcinoma10.3
31prostatitis10.3
32nasal cavity squamous cell carcinoma10.2
33ethmoid sinusitis10.2
34frontal sinusitis10.2
35hyperostosis10.2
36renal cell carcinoma10.2
37renal pelvis carcinoma10.2
38ureter urothelial papilloma10.2
39urinary tract papillary transitional cell benign neoplasm10.2
40bladder squamous papilloma10.1
41bladder leiomyoma10.1
42ureteral obstruction10.1
43bone carcinoma10.1
44ethmoid sinus adenocarcinoma10.1
45papillary squamous carcinoma10.1
46rhinoscleroma10.1
47hydronephrosis10.1
48schneiderian carcinoma10.1
49intussusception10.1
50monophasic synovial sarcoma10.1

Graphical network of the top 20 diseases related to Inverted Papilloma:



Diseases related to inverted papilloma

Clinical Features for Inverted Papilloma

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Drugs & Therapeutics for Inverted Papilloma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Inverted Papilloma

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Anatomical Context for Inverted Papilloma

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32MalaCards
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MalaCards organs/tissues related to Inverted Papilloma:

32
Bone, Prostate, Cervix, Skin, Salivary gland, Colon, Pituitary, Endothelial, T cells, Lymph node, Tonsil

Animal Models for Inverted Papilloma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Inverted Papilloma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053799.8FOXP3, CDKN2A, CDX2, CDKN1A, MSX2, CTSS
2MP:00053819.8CDKN2A, FOXP3, CTSS, PPARD, DSG3, CDX2
3MP:00053979.6CTSS, MSX2, FGFR3, PCNA, CDKN1A, CDKN2A
4MP:00107719.6PPARD, DSG3, CDKN2A, CDKN1A, MSX2, FOXP3
5MP:00053879.5FGFR3, PCNA, CDKN1A, CDKN2A, FSCN1, DSG3
6MP:00053789.5DSG3, ACTC1, FGFR3, PCNA, CDKN1A, CDX2
7MP:00053849.3KRT7, ACTC1, FGFR3, PCNA, CDKN1A, CDX2

Publications for Inverted Papilloma

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50PubMed
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Articles related to Inverted Papilloma:

(show top 50)    (show all 482)
idTitleAuthorsYear
1
The role of tissue factor pathway inhibitor-2 in malignant transformation of sinonasal inverted papilloma. (24318421)
2013
2
Synchronous verrucous carcinoma and inverted papilloma of the lacrimal sac: case report and clinical update. (24170467)
2013
3
Efficacy of 5-Aminolevulinic Acid Photodynamic Therapy in treatment of nasal inverted papilloma. (24284110)
2013
4
Squamous cell carcinoma antigen as a marker of sinonasal inverted papilloma. (23778724)
2013
5
Endoscopic surgery to treat inverted papilloma: which are the limits? (23743740)
2013
6
Concomitant inverted papilloma and fungus ball in unilateral maxillary sinus. (23641595)
2013
7
Monophasic epithelial synovial sarcoma accompanied by an inverted papilloma in the sphenoid sinus. (23251173)
2012
8
The expression and significance of smac, XIAP, caspase-3 in nonnasal inverted papilloma]. (23156805)
2012
9
Inverted papilloma of the prostatic urethra arising in a juvenile. (23596612)
2012
10
Bilateral endoscopic medial maxillectomy for bilateral inverted papilloma. (22953103)
2012
11
Downregulation of DLEC1 in sinonasal inverted papilloma and squamous cell carcinoma. (22569009)
2012
12
Blood transfusion requirements for endoscopic sinonasal inverted papilloma resections. (23700587)
2012
13
Inverted papilloma (Schneiderian papilloma) with involvement of the oral cavity: report of an unusual case. (21987149)
2011
14
Role of endoscopic approach in the management of inverted papilloma. (21191294)
2011
15
Inverting papilloma of the temporal bone: case report and meta-analysis of risk factors. (21817933)
2011
16
Inverted papilloma: a clinico-pathological dilemma with special reference to recurrence and malignant transformation. (22319692)
2010
17
Possible role of 18FDG-PET/CT for the surveillance of sinonasal inverted papilloma. (20636761)
2010
18
Frontal sinus inverted papilloma: surgical strategy based on the site of attachment. (19490812)
2009
19
Inverted papilloma arising primarily from the lacrimal sac. (19839908)
2009
20
Inverted papilloma of the sphenoid sinus: clinical presentation, management, and systematic review of the literature. (19798734)
2009
21
18F-FDG PET/CT findings of sinonasal inverted papilloma with or without coexistent malignancy: comparison with MR imaging findings in eight patients. (19259656)
2009
22
Minimally invasive resection of frontal sinus inverted papilloma: is it always a radical approach? (19027519)
2009
23
Expression of p53, p16INK4A, pRb, p21WAF1/CIP1, p27KIP1, cyclin D1, Ki-67 and HPV DNA in sinonasal endophytic Schneiderian (inverted) papilloma. (19863319)
2009
24
Do different disorders in cell cycle regulation account for different biological behavior of urothelial and sinonasal inverted papillomas? (18334838)
2008
25
Attachment-oriented endoscopic surgical strategy for sinonasal inverted papilloma. (19178804)
2008
26
Clinical and pathological analysis of recurrent inverted papilloma. (17491531)
2007
27
Inverted papilloma of the nasal cavity and paranasal sinuses. (17921720)
2007
28
Minimally invasive resection of frontal recess/sinus inverted papilloma. (17606034)
2007
29
Outcomes of the extended endoscopic approach for management of inverted papilloma. (17459277)
2007
30
Non-necrotic invasive squamous cell carcinoma associated with an inverted papilloma: MRI features. (16715677)
2006
31
Sinonasal inverted papilloma in eastern part of Nepal. (18603949)
2006
32
Increased expression of matrix metalloproteinase-2 and 9 and human papilloma virus infection are associated with malignant transformation of sinonasal inverted papilloma. (16353190)
2006
33
Clinical studies on inverted papilloma of the urinary tract: report of 48 cases and review of the literature. (14501726)
2003
34
Minimally invasive treatment of the nasal inverted papilloma. (14750608)
2003
35
Inverted papilloma of the nasal cavity presenting with massive amounts of squamous metaplastic cells in sputum. A case report. (12040661)
2002
36
Intracranial extension of inverted papilloma: An unusual and potentially fatal complication. (10562682)
1999
37
Apoptosis and p53 in inverting papilloma of the sinonasal tract. (10631397)
1999
38
Huge hamartoma with inverted papilloma in the nasal cavity. (10337524)
1999
39
Inverted papilloma - an analysis of 30 cases. (23119386)
1998
40
Invasive transitional cell carcinoma of the lacrimal sac arising in an inverted papilloma. (8129653)
1994
41
Ectopic production of beta-human chorionic gonadotropin by inverted papilloma of the nose. (2449510)
1988
42
Inverted papilloma--a modified surgical approach to reconstruction of the palate. (3163490)
1988
43
Inverted papilloma of the ureter with malignant transformation: a case report and review of the literature. The importance of the recognition of the inverted papillary tumor of the ureter. (3296385)
1987
44
Inverted papilloma of the nose. Some aspects of aetiology. (6715979)
1984
45
Inverted papilloma of the nose. (7299256)
1981
46
Management of inverted papilloma of the nose and paranasal sinuses. (7321725)
1981
47
Inverted papilloma in a 14-year-old male. (466016)
1979
48
Inverted papilloma of bladder. (4769522)
1973
49
Inverted papilloma of the nasal cavity and paranasal sinuses. (5120857)
1971
50
Inverted papilloma and squamous carcinoma. An unusual case. (5684577)
1968

Genetic Variations for Inverted Papilloma

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Expression for genes affiliated with Inverted Papilloma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Inverted Papilloma

Search GEO for disease gene expression data for Inverted Papilloma.

Pathways for genes affiliated with Inverted Papilloma

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37NCBI BioSystems Database, 4Cell Signaling Technology, 29KEGG, 53Reactome, 12EMD Millipore
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Compounds for genes affiliated with Inverted Papilloma

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44Novoseek, 11DrugBank, 49PharmGKB, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 2BitterDB
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Compounds related to Inverted Papilloma according to GeneCards/GeneDecks:

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idCompoundScoreTop Affiliating Genes
1butyrate4410.7CDX2
2mucicarmine4410.5ACTC1, KRT20, KRT7
3reticulin4410.5KRT7, PCNA, ACTC1
4optimax4410.5IFI27, CDKN1A
5olomoucine44 1111.5PCNA, CDKN1A, CDKN2A
6p000484410.5CDKN1A, IFI27
7temozolomide44 1111.5CDKN1A, CDKN2A, PCNA
8norcantharidin4410.5MKI67, IFI27, PCNA
9paclitaxel44 49 1112.5CDKN1A, CDKN2A, TOP2A, IFI27
10sulindac44 1111.4CDKN1A, PCNA, PPARD, IFI27
11methanol44 2411.4ACTC1, KRT7, CDKN2A, MKI67
12b 7234410.4KRT20, KRT7, ACTC1, PCNA
13roscovitine4410.4CDKN2A, IFI27, CDKN1A, PCNA
14eb 108944 5911.4PCNA, IFI27, CDKN1A
15valproic acid44 49 11 2413.4PCNA, PPARD, CDKN2A, CDKN1A
16troglitazone44 28 59 1113.4IFI27, PPARD, CDKN1A, KRT20, KRT13
17docetaxel44 49 59 1113.4CDKN2A, PPARD, TOP2A, CDKN1A
18tachyplesin i4410.4CDKN2A, PCNA
19streptavidin4410.4KRT20, KRT7, MKI67
20biotin44 11 2412.3ACTC1, CDKN2A, PCNA, MKI67
21cytarabine44 49 1112.3CDKN1A, PCNA, IFI27, TOP2A, CDKN2A
225-aza-2deoxycytidine4410.3CDKN2A, CDX2, KRT7, PCNA, CDKN1A
23fatty acid4410.3IFI27, TOP2A, PPARD, CSTA, CDKN2A, CDX2
24vitamin d4410.3IFI27, CDX2, PPARD, KRT13, CDKN1A
25camptothecin44 59 1112.3CDKN2A, TOP2A, CDKN1A, PCNA
26ns 39844 5911.3CDKN1A, PPARD, PCNA
27formaldehyde44 2411.3ACTC1, KRT20, KRT7, PCNA, MKI67
285fluorouracil4410.3TOP2A, MKI67, CDKN2A, CDKN1A, PCNA
29methotrexate44 49 1112.2MKI67, PCNA, CDKN2A, KRT7, TOP2A
30thymidylate4410.2TOP2A, CDKN2A, CDKN1A, PCNA, IFI27, MKI67
31hematoxylin4410.2ACTC1, KRT20, PCNA, MKI67, CDKN2A, KRT7
32mg 13244 5911.2CDKN2A, CDKN1A, PCNA, IFI27
33steroid4410.2TOP2A, MKI67, CDKN2A, ACTC1, MSX2, IFI27
34bromodeoxyuridine4410.2PCNA, CDKN1A, IFI27, MKI67
35thymidine44 2411.1PCNA, CDKN1A, CDX2, MKI67, TOP2A, IFI27
36cisplatin44 49 59 1113.1CDKN1A, MKI67, TOP2A, IFI27, PCNA, CDKN2A
37doxorubicin44 49 1112.1CDKN2A, CDKN1A, MKI67, TOP2A, IFI27, KRT20
38oligonucleotide4410.1CDKN2A, CDX2, IFI27, CDKN1A, PCNA, FGFR3
39dexamethasone44 49 28 1113.0PCNA, IFI27, PPARD, CDKN2A
40calcium44 49 11 2413.0KRT13, IFI27, ACTC1, DSG3, CDX2, FGFR3
41genistein44 28 59 2 11 2415.0PCNA, CDKN1A, TOP2A, CDKN2A, IFI27
42testosterone44 59 11 2413.0TOP2A, PCNA, IFI27, MKI67, CDKN2A, ACTC1
43threonine449.8CDKN2A, CDKN1A, FGFR3, FSCN1, MKI67, IFI27
44progesterone44 59 28 11 2413.8ACTC1, IFI27, TOP2A, MKI67, CDX2, CDKN1A
45retinoic acid44 2410.7CDKN2A, ACTC1, KRT13, KRT7, FSCN1, CDKN1A
46vegf449.7CDKN2A, MKI67, TOP2A, CDKN1A, IFI27, PPARD
47serine449.5CDKN1A, CDKN2A, MKI67, FSCN1, DSG3, TOP2A
48tyrosine449.5IFI27, CSTA, PPARD, TOP2A, ACTC1, DSG3
49paraffin449.5IFI27, CDKN1A, FSCN1, KRT7, KRT20, PCNA
50arginine449.5IFI27, FGFR3, PCNA, CDKN2A, KRT7, MKI67

GO Terms for genes affiliated with Inverted Papilloma

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16Gene Ontology
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Cellular components related to Inverted Papilloma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:07006210.2SERPINB3, ACTC1, KRT13
2PCNA-p21 complexGO:0705579.9PCNA, CDKN1A

Biological processes related to Inverted Papilloma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of CREB transcription factor activityGO:03279210.3MSX2, FOXP3
2anagenGO:04264010.3MSX2, PPARD
3endochondral bone growthGO:00341610.2FGFR3, MSX2
4phosphatidylinositol-mediated signalingGO:04801510.1FGFR3, PCNA, CDKN1A, TOP2A
5negative regulation of peptidase activityGO:01046610.0SERPINB3, CSTA

Molecular functions related to Inverted Papilloma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase inhibitor activityGO:00486110.3CDKN1A, CDKN2A
2drug bindingGO:0081449.9FSCN1, TOP2A, PPARD

Products for genes affiliated with Inverted Papilloma

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Sources for Inverted Papilloma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet