MCID: INV006
MIFTS: 52

Inverted Papilloma malady

Summaries for Inverted Papilloma

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63Wikipedia, 32MalaCards
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Wikipedia:63 An inverted papilloma is a type of tumor in which surface epithelial cells grow downward into the... more...

MalaCards: Inverted Papilloma, also known as inverted papilloma, squamous cell, is related to papilloma and squamous cell carcinoma. An important gene associated with Inverted Papilloma is KRT13 (keratin 13), and among its related pathways are Senescence and Autophagy and Cytoskeletal Signaling. The compounds butyrate and mucicarmine have been mentioned in the context of this disorder. Affiliated tissues include bone, prostate and cervix, and related mouse phenotypes are endocrine/exocrine gland and digestive/alimentary.

Aliases & Classifications for Inverted Papilloma

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8Disease Ontology, 10DISEASES, 60UMLS, 44Novoseek, 39NCIt, 34MeSH
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Aliases & Descriptions:

inverted papilloma 8 10 60
inverted papilloma, squamous cell 8
papilloma inverted 44


External Ids:

Disease Ontology8 DOID:3179
NCIt39 C3793
MeSH34 D018308

Related Diseases for Inverted Papilloma

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17GeneCards, 18GeneDecks
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Diseases related to Inverted Papilloma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 184)
idRelated DiseaseScoreTop Affiliating Genes
1papilloma32.1IFI27, CDKN2A, CDKN1A, PCNA, FGFR3, FSCN1
2squamous cell carcinoma31.1FSCN1, KRT7, KRT20, KRT13, ACTC1, SERPINB3
3transitional cell carcinoma30.9IFI27, TOP2A, MKI67, CDKN1A, PCNA, FGFR3
4bladder carcinoma30.8IFI27, TOP2A, MKI67, CDKN2A, CDKN1A, PCNA
5bladder transitional cell papilloma30.8FGFR3
6bladder transitional cell carcinoma30.7KRT20, MKI67, IFI27
7papillary carcinoma30.6IFI27, MKI67, KRT7, KRT20, ACTC1
8adenocarcinoma30.5KRT13, ACTC1, SERPINB3, KRT20, KRT7, FSCN1
9colon adenocarcinoma30.1KRT20, CDKN1A
10leiomyoma30.1ACTC1, PCNA, MKI67
11sarcoma30.1TOP2A, MKI67, FSCN1, ACTC1
12synovial sarcoma30.1KRT13, KRT7, MKI67
13bladder carcinoma in situ30.1CDKN2A, PCNA, FGFR3, KRT20, SERPINB3
14melanoma30.1MKI67, TOP2A, PPARD, FOXP3, IFI27, CDKN2A
15urinary bladder inverted papilloma10.8
16ureter inverted papilloma10.8
17squamous cell papilloma10.8
18nasal cavity inverting papilloma10.8
19frontal sinus inverted papilloma10.7
20sphenoid sinus inverted papilloma10.7
21maxillary sinus inverted papilloma10.7
22renal pelvis inverted papilloma10.6
23inverted transitional papilloma10.6
24transitional papilloma10.6
25urethra inverted papilloma10.6
26ethmoid sinus inverted papilloma10.4
27papillary transitional carcinoma10.4
28verrucous carcinoma10.3
29verrucous papilloma10.3
30in situ carcinoma10.3
31prostatitis10.3
32nasal cavity squamous cell carcinoma10.2
33ethmoid sinusitis10.2
34frontal sinusitis10.2
35hyperostosis10.2
36renal cell carcinoma10.2
37renal pelvis carcinoma10.2
38ureter urothelial papilloma10.2
39urinary tract papillary transitional cell benign neoplasm10.2
40bladder squamous papilloma10.1
41bladder leiomyoma10.1
42ureteral obstruction10.1
43bone carcinoma10.1
44ethmoid sinus adenocarcinoma10.1
45papillary squamous carcinoma10.1
46rhinoscleroma10.1
47hydronephrosis10.1
48schneiderian carcinoma10.1
49intussusception10.1
50monophasic synovial sarcoma10.1

Graphical network of the top 20 diseases related to Inverted Papilloma:



Diseases related to inverted papilloma

Clinical Features for Inverted Papilloma

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Drugs & Therapeutics for Inverted Papilloma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Inverted Papilloma

Genetic Tests for Inverted Papilloma

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Anatomical Context for Inverted Papilloma

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32MalaCards
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MalaCards organs/tissues related to Inverted Papilloma:

32
Bone, Prostate, Cervix, Colon, Salivary gland, Skin, Lymph node, Tonsil, T cells, Endothelial, Pituitary

Animal Models for Inverted Papilloma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Inverted Papilloma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053799.8FOXP3, CTSS, CDKN2A, CDX2, CDKN1A, MSX2
2MP:00053819.8MSX2, FOXP3, CTSS, PPARD, DSG3, CDKN2A
3MP:00053979.6CTSS, DSG3, CDKN2A, CDKN1A, PCNA, FGFR3
4MP:00107719.6FOXP3, PPARD, DSG3, CDKN2A, CDKN1A, MSX2
5MP:00053879.5FOXP3, CTSS, PPARD, DSG3, CDKN2A, CDKN1A
6MP:00053789.5CDKN2A, DSG3, PPARD, FOXP3, CDX2, CDKN1A
7MP:00053849.3CDKN2A, DSG3, PPARD, CTSS, FOXP3, CDX2

Publications for Inverted Papilloma

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50PubMed
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Articles related to Inverted Papilloma:

(show top 50)    (show all 482)
idTitleAuthorsYear
1
Production and significance of CCAAT enhancer binding proteins alpha and beta in sinonasal inverted papilloma. (23233059)
2013
2
Long-term clinical outcome of inverted urothelial papilloma including cases with focal papillary pattern: is continuous surveillance necessary? (24074985)
2013
3
Radiology quiz case 2. Recurrent inverted papilloma (IP) with focal hyperostosis in the right maxillary sinus. (23657711)
2013
4
Apoptotic and proliferative status in HPV (+) and HPV (-) inverted papilloma patients. Correlation with local recurrence and clinicopathological variables. (22560505)
2012
5
Human papillomavirus load and physical status in sinonasal inverted papilloma and squamous cell carcinoma. (22469610)
2012
6
Clinical and histologic features of inverted papilloma-associated malignancy. (22271282)
2012
7
Sinonasal inverted papilloma associated with malignancy: the role of human papillomavirus infection and its implications for radiotherapy. (22098797)
2012
8
Sinonasal carcinoma associated with inverted papilloma: a report of 16 cases. (21855361)
2012
9
Inverted papilloma of the nasal cavity and paranasal sinuses: a Korean multicenter study. (22253070)
2012
10
Significance and expression of VEGF and its receptor in nasal inverted papillomas and the correlation with malignant phenotype]. (22730813)
2012
11
Benign inverted papilloma with intracranial extension: prognostic factors and outcomes. (23984218)
2011
12
Etiological role of human papillomavirus infection for inverted papilloma of the bladder. (21181923)
2011
13
Endoscopic management of sinonasal inverted papilloma. (23765136)
2011
14
Endoscopic treatment of maxillary inverted papilloma. (21858271)
2011
15
Bilateral cavernous sinus involvement by perineural spread of inverted papilloma. (20855688)
2010
16
Inverted papilloma of the urinary bladder: Rigorous surveillance needed? An Indian experience. (21131756)
2010
17
Bilateral inverted papilloma: A report of two cases and review of the current literature. (23120732)
2010
18
Desmoglein 3 is overexpressed in inverted papilloma and squamous cell carcinoma of sinonasal cavity. (19688857)
2010
19
Expression of epidermal growth factor receptor in the inverted papilloma and squamous cell carcinoma of nasal cavity. (18231801)
2008
20
Human topoisomerase II-alpha is highly expressed in sinonasal-inverted papilloma, but not in inflammatory polyp. (18544048)
2008
21
New staging system for sinonasal inverted papilloma in the endoscopic era. (17632914)
2007
22
Endoscopic management of inverted papilloma. (16467632)
2006
23
Inverted papilloma of the urinary bladder: a molecular genetic appraisal. (16862073)
2006
24
Staging of surgical approach of sinonasal inverted papilloma. (15927429)
2005
25
Endoscopic removal of sinonasal inverted papilloma including endoscopic medial maxillectomy. (12792324)
2003
26
Serum squamous cell carcinoma antigen is a useful biologic marker in patients with inverted papillomas of the sinonasal tract. (11815971)
2002
27
Inverted papilloma: a review of 53 cases. (11568576)
2001
28
Inverted urothelial papilloma: is ploidy, MIB-1 proliferative activity, or p53 protein accumulation predictive of urothelial carcinoma? (10649258)
2000
29
Prevalence of six types of human papillomavirus in inverted papilloma and papillary transitional cell carcinoma of the bladder: an evaluation by polymerase chain reaction. (9516885)
1997
30
Inverted papilloma of nose and paranasal sinuses -surgical dilemma. (23119247)
1997
31
Biological characteristics of inverted papilloma of the urinary bladder. (8653317)
1996
32
Squamous cell carcinoma arising in inverted papilloma. (8544600)
1995
33
Nuclear deoxyribonucleic acid content in inverted papilloma of the urothelium. (7957471)
1994
34
Synchronous inverted papilloma and submucosal leiomyoma of the urinary bladder. (7627857)
1994
35
Inverted papilloma: a follow-up study including primarily unacknowledged cases. (2764240)
1989
36
Inverted papilloma of the ureter. (3177116)
1988
37
Proptosis from maxillary sinus inverted papilloma with malignant transformation. (3718313)
1986
38
Inverted papilloma of the nasal cavity and paranasal sinuses: report of three cases and review of the literature. (3331571)
1986
39
Inverted papilloma. Considerations in treatment. (4062652)
1985
40
Inverted papilloma of the nose (Ringertz tumour). (4086856)
1985
41
Inverted papilloma: observation with scanning and transmission electron microscopy. (3925623)
1985
42
Inverted papilloma of the ureter. (6498445)
1984
43
Radiological changes associated with inverted papilloma of the nose and paranasal sinuses. (6722445)
1984
44
Inverted papilloma of the upper urinary tract. (6839089)
1983
45
The role of conservative surgery in the management of inverted papilloma. (6823183)
1983
46
Pathologic quiz case 2. Squamous carcinoma in a patient with previous inverted papilloma. (7073601)
1982
47
Inverted papilloma of the maxillary sinus. (7292079)
1981
48
Chronic inflammation of the ureter with urothelial ingrowth simulating inverted papilloma. (7470807)
1981
49
Inverted papilloma of the nose and paranasal sinuses. (4831934)
1974
50
Oropharyngeal inverted papilloma. (4841457)
1974

Genetic Variations for Inverted Papilloma

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Expression for genes affiliated with Inverted Papilloma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Inverted Papilloma

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Pathways for genes affiliated with Inverted Papilloma

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37NCBI BioSystems Database, 4Cell Signaling Technology, 29KEGG, 53Reactome, 12EMD Millipore
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Compounds for genes affiliated with Inverted Papilloma

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44Novoseek, 11DrugBank, 49PharmGKB, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 2BitterDB
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Compounds related to Inverted Papilloma according to GeneCards/GeneDecks:

(show top 50)    (show all 67)
idCompoundScoreTop Affiliating Genes
1butyrate4410.7CDX2
2mucicarmine4410.5ACTC1, KRT20, KRT7
3reticulin4410.5KRT7, PCNA, ACTC1
4optimax4410.5IFI27, CDKN1A
5olomoucine44 1111.5PCNA, CDKN1A, CDKN2A
6p000484410.5CDKN1A, IFI27
7temozolomide44 1111.5CDKN1A, CDKN2A, PCNA
8norcantharidin4410.5MKI67, IFI27, PCNA
9paclitaxel44 49 1112.5CDKN1A, CDKN2A, TOP2A, IFI27
10sulindac44 1111.4CDKN1A, PCNA, PPARD, IFI27
11methanol44 2411.4ACTC1, KRT7, CDKN2A, MKI67
12b 7234410.4KRT20, KRT7, ACTC1, PCNA
13roscovitine4410.4CDKN2A, IFI27, CDKN1A, PCNA
14eb 108944 5911.4PCNA, IFI27, CDKN1A
15valproic acid44 49 11 2413.4PCNA, PPARD, CDKN2A, CDKN1A
16troglitazone44 28 59 1113.4IFI27, PPARD, CDKN1A, KRT20, KRT13
17docetaxel44 49 59 1113.4CDKN2A, PPARD, TOP2A, CDKN1A
18tachyplesin i4410.4CDKN2A, PCNA
19streptavidin4410.4KRT20, KRT7, MKI67
20biotin44 11 2412.3ACTC1, CDKN2A, PCNA, MKI67
21cytarabine44 49 1112.3CDKN1A, PCNA, IFI27, TOP2A, CDKN2A
225-aza-2deoxycytidine4410.3CDKN2A, CDX2, KRT7, PCNA, CDKN1A
23fatty acid4410.3IFI27, TOP2A, PPARD, CSTA, CDKN2A, CDX2
24vitamin d4410.3IFI27, CDX2, PPARD, KRT13, CDKN1A
25camptothecin44 59 1112.3CDKN2A, TOP2A, CDKN1A, PCNA
26ns 39844 5911.3CDKN1A, PPARD, PCNA
27formaldehyde44 2411.3ACTC1, KRT20, KRT7, PCNA, MKI67
285fluorouracil4410.3TOP2A, MKI67, CDKN2A, CDKN1A, PCNA
29methotrexate44 49 1112.2MKI67, PCNA, CDKN2A, KRT7, TOP2A
30thymidylate4410.2TOP2A, CDKN2A, CDKN1A, PCNA, IFI27, MKI67
31hematoxylin4410.2ACTC1, KRT20, PCNA, MKI67, CDKN2A, KRT7
32mg 13244 5911.2CDKN2A, CDKN1A, PCNA, IFI27
33steroid4410.2TOP2A, MKI67, CDKN2A, ACTC1, MSX2, IFI27
34bromodeoxyuridine4410.2PCNA, CDKN1A, IFI27, MKI67
35thymidine44 2411.1PCNA, CDKN1A, CDX2, MKI67, TOP2A, IFI27
36cisplatin44 49 59 1113.1CDKN1A, MKI67, TOP2A, IFI27, PCNA, CDKN2A
37doxorubicin44 49 1112.1CDKN2A, CDKN1A, MKI67, TOP2A, IFI27, KRT20
38oligonucleotide4410.1CDKN2A, CDX2, IFI27, CDKN1A, PCNA, FGFR3
39dexamethasone44 49 28 1113.0PCNA, IFI27, PPARD, CDKN2A
40calcium44 49 11 2413.0KRT13, IFI27, ACTC1, DSG3, CDX2, FGFR3
41genistein44 28 59 2 11 2415.0PCNA, CDKN1A, TOP2A, CDKN2A, IFI27
42testosterone44 59 11 2413.0TOP2A, PCNA, IFI27, MKI67, CDKN2A, ACTC1
43threonine449.8CDKN2A, CDKN1A, FGFR3, FSCN1, MKI67, IFI27
44progesterone44 59 28 11 2413.8ACTC1, IFI27, TOP2A, MKI67, CDX2, CDKN1A
45retinoic acid44 2410.7CDKN2A, ACTC1, KRT13, KRT7, FSCN1, CDKN1A
46vegf449.7CDKN2A, MKI67, TOP2A, CDKN1A, IFI27, PPARD
47serine449.5CDKN1A, CDKN2A, MKI67, FSCN1, DSG3, TOP2A
48tyrosine449.5IFI27, CSTA, PPARD, TOP2A, ACTC1, DSG3
49paraffin449.5IFI27, CDKN1A, FSCN1, KRT7, KRT20, PCNA
50arginine449.5IFI27, FGFR3, PCNA, CDKN2A, KRT7, MKI67

GO Terms for genes affiliated with Inverted Papilloma

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16Gene Ontology
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Cellular components related to Inverted Papilloma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:07006210.2SERPINB3, ACTC1, KRT13
2PCNA-p21 complexGO:0705579.9PCNA, CDKN1A

Biological processes related to Inverted Papilloma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of CREB transcription factor activityGO:03279210.3MSX2, FOXP3
2anagenGO:04264010.3MSX2, PPARD
3endochondral bone growthGO:00341610.2FGFR3, MSX2
4phosphatidylinositol-mediated signalingGO:04801510.1FGFR3, PCNA, CDKN1A, TOP2A
5negative regulation of peptidase activityGO:01046610.0SERPINB3, CSTA

Molecular functions related to Inverted Papilloma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase inhibitor activityGO:00486110.3CDKN1A, CDKN2A
2drug bindingGO:0081449.9FSCN1, TOP2A, PPARD

Products for genes affiliated with Inverted Papilloma

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Sources for Inverted Papilloma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet