MCID: IRD003
MIFTS: 23

Iridocorneal Endothelial Syndrome malady

Categories: Rare diseases, Eye diseases, Fetal diseases

Aliases & Classifications for Iridocorneal Endothelial Syndrome

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Sources:
31ICD10 via Orphanet, 40MESH via Orphanet, 48NIH Rare Diseases, 54Orphanet, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Iridocorneal Endothelial Syndrome:

Name: Iridocorneal Endothelial Syndrome 48 54
Ice Syndrome 48 54
 
Ichthyosis--Cheek--Eyebrow Syndrome 68

Characteristics:

Orphanet epidemiological data:

54
iridocorneal endothelial syndrome:
Inheritance: Not applicable; Age of onset: Adult

Classifications:



External Ids:

Orphanet54 ORPHA64734
MESH via Orphanet40 D057129
UMLS via Orphanet69 C0339285, C1096100
ICD10 via Orphanet31 H21.1

Summaries for Iridocorneal Endothelial Syndrome

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NIH Rare Diseases:48 Iridocorneal endothelial (ICE) syndrome describes a group of eye diseases that are characterized by three main features:  Visible changes in the iris (the colored part of the eye that regulates the amount of light entering the eye)  Swelling of the cornea, and  The development of glaucoma (a disease that can cause severe vision loss when normal fluid inside the eye cannot drain properly) ICE syndrome, is more common in women than men, most commonly diagnosed in middle age, and is usually present in only one eye. The condition is actually a grouping of three closely linked conditions: Cogan-Reese syndrome; Chandler's syndrome; and essential (progressive) iris atrophy. The cause of ICE syndrome is unknown, however there is a theory that it is triggered by a virus that leads to swelling of the cornea. While there is no way to stop the progression of the condition, treatment of the symptoms may include medication for glaucoma and corneal transplant for corneal swelling. Last updated: 12/1/2015

MalaCards based summary: Iridocorneal Endothelial Syndrome, also known as ice syndrome, is related to corneal endothelial dystrophy and essential iris atrophy. An important gene associated with Iridocorneal Endothelial Syndrome is KRT3 (Keratin 3). Affiliated tissues include endothelial and eye.

Wikipedia:71 Iridocorneal Endothelial (ICE) syndromes are a spectrum of diseases characteriezed by slowly progressive... more...

Related Diseases for Iridocorneal Endothelial Syndrome

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Diseases related to Iridocorneal Endothelial Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1corneal endothelial dystrophy11.1
2essential iris atrophy10.9
3endotheliitis10.8
4herpes simplex10.0
5keratoconus9.8
6retinitis9.8
7glaucomatocyclitic crisis9.8

Graphical network of diseases related to Iridocorneal Endothelial Syndrome:



Diseases related to iridocorneal endothelial syndrome

Symptoms & Phenotypes for Iridocorneal Endothelial Syndrome

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Drugs & Therapeutics for Iridocorneal Endothelial Syndrome

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Drugs for Iridocorneal Endothelial Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Pharmaceutical SolutionsPhase 1, Phase 27793
2Ophthalmic SolutionsPhase 1, Phase 21092

Interventional clinical trials:

idNameStatusNCT IDPhase
1Evaluating Results of Neusidl Corneal Inserter in Descemet's Stripping Automated Endothelial Keratoplasty (DSAEK)Unknown statusNCT01357122Phase 4
2A Study Investigating the Safety, Tolerability, and Efficacy of Elamipretide Topical Ophthalmic Solution for the Treatment of Fuchs' Corneal Endothelial Dystrophy (FCED)Active, not recruitingNCT02653391Phase 1, Phase 2
3Outcome After Descemet Membrane Endothelial Keratoplasty (DMEK) and Ultra-thin Descemet Stripping Automated Endothelial Keratoplasty (DSAEK)Unknown statusNCT02020044
4Early Experience With Descemet's Stripping Automated Endothelial KeratoplastyUnknown statusNCT00744796
5Abnormalities of the Eye's Anterior Chamber, Iris, Cornea and LensCompletedNCT00001161
6Fuchs' Endothelial Dystrophy: Clinical Characteristics, Treatment Outcome, and PathologyCompletedNCT01979250
7Study of Endothelial Keratoplasty OutcomesRecruitingNCT00800111
8Specular Microscopy StudyRecruitingNCT02478970
9The Molecular Pathogenesis of Late-onset Fuchs' Endothelial Corneal DystrophyRecruitingNCT01795001
10Assessment of Corneal Graft Attachment in Patients With Fuchs Endothelial Corneal Dystrophy Following DMEK Using Ultra-high Resolution OCTNot yet recruitingNCT02542644

Search NIH Clinical Center for Iridocorneal Endothelial Syndrome

Genetic Tests for Iridocorneal Endothelial Syndrome

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Anatomical Context for Iridocorneal Endothelial Syndrome

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MalaCards organs/tissues related to Iridocorneal Endothelial Syndrome:

36
Endothelial, Eye

Publications for Iridocorneal Endothelial Syndrome

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Articles related to Iridocorneal Endothelial Syndrome:

(show top 50)    (show all 85)
idTitleAuthorsYear
1
Cystoid macular edema associated with iridocorneal endothelial syndrome: a case report. (27585567)
2016
2
Surgical outcomes of patients with iridocorneal endothelial syndrome: a case series. (27495952)
2016
3
Trabeculectomy with Mitomycin-C in Patients with Iridocorneal Endothelial Syndrome: A Case Series. (27437260)
2016
4
Post Filtering Surgery Globe Massage-induced Keratoconus in an Eye with Iridocorneal Endothelial Syndrome: A Case Report and Literature Brief Review. (27621792)
2016
5
Concurrent Acute Retinal Necrosis in a Patient With Iridocorneal Endothelial Syndrome. (27362881)
2016
6
Iridocorneal Endothelial Syndrome Presenting With Large Diurnal Intraocular Pressure Fluctuation. (27977477)
2016
7
Diagnosis and Management of Iridocorneal Endothelial Syndrome. (26451377)
2015
8
Graft Failure and Intraocular Pressure Control After Keratoplasty in Iridocorneal Endothelial Syndrome. (26525380)
2015
9
Outcomes of Primary Trabeculectomy With Mitomycin-C in Glaucoma Secondary to Iridocorneal Endothelial Syndrome. (25943731)
2015
10
Graft failure and intraocular pressure control after keratoplasty in iridocorneal endothelial syndrome. (26032193)
2015
11
Descemet Stripping Endothelial Keratoplasty in Iridocorneal Endothelial Syndrome: Postoperative Complications and Long-Term Outcomes. (26203744)
2015
12
Graft Failure and Intraocular Pressure Control After Keratoplasty in Iridocorneal Endothelial Syndrome. (26514395)
2015
13
Iridocorneal Endothelial Syndrome in a 14-Year-Old Male. (26035422)
2015
14
Concurrence of iridocorneal endothelial syndrome in a patient with glaucomatocyclitic crisis. (24790889)
2014
15
Phenotypic heterogeneity of corneal endothelium in iridocorneal endothelial syndrome by in vivo confocal microscopy. (24727634)
2014
16
Iridocorneal endothelial syndrome. (24407828)
2014
17
Iridocorneal endothelial syndrome. (24906259)
2014
18
Retrocorneal membrane formation after Baerveldt shunt implantation for iridocorneal endothelial syndrome. (23538633)
2013
19
Intracameral injection of tissue plasminogen activator to treat severe postoperative fibrinous reaction in iridocorneal endothelial syndrome. (24109245)
2013
20
Iridocorneal endothelial syndrome in a Chinese child. (24579558)
2013
21
Management of detached graft donor by SFa88 injection following Descemet stripping automated endothelial keratoplasty of an eye with iridocorneal endothelial syndrome and Ahmed glaucoma drainage tube. (22752650)
2012
22
Clinicopathologic findings in iridocorneal endothelial syndrome and posterior polymorphous membranous dystrophy after Descemet stripping automated endothelial keratoplasty. (22333668)
2012
23
Iridocorneal endothelial syndrome masquerading as iris melanoma in 71 cases. (21482858)
2011
24
Iridocorneal endothelial syndrome in a 16-year-old. (20616751)
2011
25
Bilateral iridocorneal endothelial syndrome in a young girl with Down's syndrome. (19075416)
2009
26
Deep lamellar endothelial keratoplasty for iridocorneal endothelial syndrome in phakic eyes. (19139335)
2009
27
In-vivo confocal microscopy of iridocorneal endothelial syndrome. (18297250)
2009
28
Descemet's stripping with endothelial keratoplasty in iridocorneal endothelial syndrome. (18254352)
2008
29
Coexistence of unilateral iridocorneal endothelial syndrome and sensorineural deafness. (17641715)
2007
30
Descemet stripping with endothelial keratoplasty for treatment of iridocorneal endothelial syndrome. (17457204)
2007
31
Reduced corneal swelling and deswelling response in the iridocorneal endothelial syndrome. (17041320)
2006
32
Ultrasound biomicroscopy of Chinese eyes with iridocorneal endothelial syndrome. (16361670)
2006
33
Iridocorneal endothelial syndrome in a child. (17022165)
2006
34
Macular edema and iridocorneal endothelial syndrome: a case report. (15725892)
2005
35
Features of the iridocorneal endothelial syndrome on confocal microscopy. (15778613)
2005
36
Iris reconstruction with a multipiece endocapsular prosthesis in iridocorneal endothelial syndrome. (16412914)
2005
37
In vivo confocal microscopic characteristics of iridocorneal endothelial syndrome. (15180840)
2004
38
Bilaminar interepithelial bodies within fingerprint dystrophy-like changes in bilateral iridocorneal endothelial syndrome. (12642328)
2003
39
Long-term surgical outcomes of patients with glaucoma secondary to the iridocorneal endothelial syndrome. (11581050)
2001
40
Penetrating keratoplasty in iridocorneal endothelial syndrome. (11248814)
2001
41
Clinical and specular microscopic manifestations of iridocorneal endothelial syndrome. (11369379)
2001
42
Posterior polymorphous membranous dystrophy with overlapping features of iridocorneal endothelial syndrome. (11296040)
2001
43
Iridocorneal endothelial syndrome in Thai patients: clinical variations. (10676783)
2000
44
Outcome of trabeculectomy with mitomycin-C in the iridocorneal endothelial syndrome. (10690828)
2000
45
Long-term outcome of aqueous shunt surgery in ten patients with iridocorneal endothelial syndrome. (10328409)
1999
46
Confocal microscopy in the iridocorneal endothelial syndrome. (10340979)
1999
47
Pseudocapsulorrhexis in a patient with iridocorneal endothelial syndrome. (10088823)
1999
48
The contralateral corneal endothelium in the iridocorneal endothelial syndrome. (9006423)
1997
49
Endothelial metaplasia in the iridocorneal endothelial syndrome. (9286281)
1997
50
The histopathology of the iridocorneal-endothelial syndrome. (8907380)
1996

Variations for Iridocorneal Endothelial Syndrome

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Expression for genes affiliated with Iridocorneal Endothelial Syndrome

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Search GEO for disease gene expression data for Iridocorneal Endothelial Syndrome.

Pathways for genes affiliated with Iridocorneal Endothelial Syndrome

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GO Terms for genes affiliated with Iridocorneal Endothelial Syndrome

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Sources for Iridocorneal Endothelial Syndrome

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet