MCID: IRD003
MIFTS: 26

Iridocorneal Endothelial Syndrome malady

Categories: Rare diseases, Eye diseases, Fetal diseases

Aliases & Classifications for Iridocorneal Endothelial Syndrome

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Sources:
45NIH Rare Diseases, 51Orphanet, 65UMLS, 66UMLS via Orphanet, 28ICD10 via Orphanet, 37MESH via Orphanet
See all MalaCards sources

Aliases & Descriptions for Iridocorneal Endothelial Syndrome:

Name: Iridocorneal Endothelial Syndrome 45 51
Ice Syndrome 45 51
 
Ichthyosis--Cheek--Eyebrow Syndrome 65

Characteristics:

Orphanet epidemiological data:

51
iridocorneal endothelial syndrome:
Inheritance: Not applicable; Age of onset: Adult

Classifications:



External Ids:

Orphanet51 64734
UMLS via Orphanet66 C0339285, C1096100
ICD10 via Orphanet28 H21.1
MESH via Orphanet37 D057129
UMLS65 C1840283

Summaries for Iridocorneal Endothelial Syndrome

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NIH Rare Diseases:45 Iridocorneal endothelial (ice) syndrome describes a group of eye diseases that are characterized by three main features:  visible changes in the iris (the colored part of the eye that regulates the amount of light entering the eye)  swelling of the cornea, and  the development of glaucoma (a disease that can cause severe vision loss when normal fluid inside the eye cannot drain properly) ice syndrome, is more common in women than men, most commonly diagnosed in middle age, and is usually present in only one eye. the condition is actually a grouping of three closely linked conditions: cogan-reese syndrome; chandler's syndrome; and essential (progressive) iris atrophy. the cause of ice syndrome is unknown, however there is a theory that it is triggered by a virus that leads to swelling of the cornea. while there is no way to stop the progression of the condition, treatment of the symptoms may include medication for glaucoma and corneal transplant for corneal swelling. last updated: 12/1/2015

MalaCards based summary: Iridocorneal Endothelial Syndrome, also known as ice syndrome, is related to chandler syndrome and endotheliitis. An important gene associated with Iridocorneal Endothelial Syndrome is KRT3 (Keratin 3). Affiliated tissues include endothelial, eye and brain.

Wikipedia:68 Iridocorneal endothelial or ICE syndrome is a spectrum of conditions of the eye, where the inner layer... more...

Related Diseases for Iridocorneal Endothelial Syndrome

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Diseases related to Iridocorneal Endothelial Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1chandler syndrome11.2
2endotheliitis10.9
3cogan-reese syndrome10.1
4endothelial dystrophy10.1
5melanoma10.1
6herpes simplex10.1
7glaucomatocyclitic crisis9.9

Graphical network of diseases related to Iridocorneal Endothelial Syndrome:



Diseases related to iridocorneal endothelial syndrome

Symptoms for Iridocorneal Endothelial Syndrome

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Drugs & Therapeutics for Iridocorneal Endothelial Syndrome

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Drugs for Iridocorneal Endothelial Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Pharmaceutical SolutionsPhase 1, Phase 27004
2Ophthalmic SolutionsPhase 1, Phase 21006

Interventional clinical trials:

idNameStatusNCT IDPhase
1Evaluating Results of Neusidl Corneal Inserter in Descemet's Stripping Automated Endothelial Keratoplasty (DSAEK)Active, not recruitingNCT01357122Phase 4
2A Study Investigating the Safety, Tolerability, and Efficacy of Elamipretide Topical Ophthalmic Solution for the Treatment of Fuchs' Corneal Endothelial Dystrophy (FCED)RecruitingNCT02653391Phase 1, Phase 2
3Abnormalities of the Eye's Anterior Chamber, Iris, Cornea and LensCompletedNCT00001161
4Study of Endothelial Keratoplasty OutcomesRecruitingNCT00800111
5Outcome After Descemet Membrane Endothelial Keratoplasty (DMEK) and Ultra-thin Descemet Stripping Automated Endothelial Keratoplasty (DSAEK)RecruitingNCT02020044
6Specular Microscopy StudyRecruitingNCT02478970
7Early Experience With Descemet's Stripping Automated Endothelial KeratoplastyRecruitingNCT00744796
8The Molecular Pathogenesis of Late-onset Fuchs' Endothelial Corneal DystrophyRecruitingNCT01795001
9Fuchs' Endothelial Dystrophy: Clinical Characteristics, Treatment Outcome, and PathologyActive, not recruitingNCT01979250
10Assessment of Corneal Graft Attachment in Patients With Fuchs Endothelial Corneal Dystrophy Following DMEK Using Ultra-high Resolution OCTNot yet recruitingNCT02542644

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Genetic Tests for Iridocorneal Endothelial Syndrome

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Anatomical Context for Iridocorneal Endothelial Syndrome

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MalaCards organs/tissues related to Iridocorneal Endothelial Syndrome:

33
Endothelial, Eye, Brain, Breast, Myeloid, Prostate, T cells

Animal Models for Iridocorneal Endothelial Syndrome or affiliated genes

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Publications for Iridocorneal Endothelial Syndrome

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Articles related to Iridocorneal Endothelial Syndrome:

(show top 50)    (show all 80)
idTitleAuthorsYear
1
Graft failure and intraocular pressure control after keratoplasty in iridocorneal endothelial syndrome. (26032193)
2015
2
Descemet Stripping Endothelial Keratoplasty in Iridocorneal Endothelial Syndrome: Postoperative Complications and Long-Term Outcomes. (26203744)
2015
3
Diagnosis and Management of Iridocorneal Endothelial Syndrome. (26451377)
2015
4
Graft Failure and Intraocular Pressure Control After Keratoplasty in Iridocorneal Endothelial Syndrome. (26514395)
2015
5
Iridocorneal Endothelial Syndrome in a 14-Year-Old Male. (26035422)
2015
6
Graft Failure and Intraocular Pressure Control After Keratoplasty in Iridocorneal Endothelial Syndrome. (26525380)
2015
7
Phenotypic heterogeneity of corneal endothelium in iridocorneal endothelial syndrome by in vivo confocal microscopy. (24727634)
2014
8
Iridocorneal endothelial syndrome. (24407828)
2014
9
Iridocorneal endothelial syndrome. (24906259)
2014
10
Concurrence of iridocorneal endothelial syndrome in a patient with glaucomatocyclitic crisis. (24790889)
2014
11
Retrocorneal membrane formation after Baerveldt shunt implantation for iridocorneal endothelial syndrome. (23538633)
2013
12
Intracameral injection of tissue plasminogen activator to treat severe postoperative fibrinous reaction in iridocorneal endothelial syndrome. (24109245)
2013
13
Management of detached graft donor by SFa88 injection following Descemet stripping automated endothelial keratoplasty of an eye with iridocorneal endothelial syndrome and Ahmed glaucoma drainage tube. (22752650)
2012
14
Iridocorneal endothelial syndrome masquerading as iris melanoma in 71 cases. (21482858)
2011
15
Bilateral iridocorneal endothelial syndrome in a young girl with Down's syndrome. (19075416)
2009
16
Deep lamellar endothelial keratoplasty for iridocorneal endothelial syndrome in phakic eyes. (19139335)
2009
17
Descemet's stripping with endothelial keratoplasty in iridocorneal endothelial syndrome. (18254352)
2008
18
Descemet stripping with endothelial keratoplasty for treatment of iridocorneal endothelial syndrome. (17457204)
2007
19
Iridocorneal endothelial syndrome in a child. (17022165)
2006
20
Macular edema and iridocorneal endothelial syndrome: a case report. (15725892)
2005
21
Features of the iridocorneal endothelial syndrome on confocal microscopy. (15778613)
2005
22
Iridocorneal endothelial syndrome in Thai patients: clinical variations. (10676783)
2000
23
Long-term outcome of aqueous shunt surgery in ten patients with iridocorneal endothelial syndrome. (10328409)
1999
24
The contralateral corneal endothelium in the iridocorneal endothelial syndrome. (9006423)
1997
25
The histopathology of the iridocorneal-endothelial syndrome. (8907380)
1996
26
Bilateral iridocorneal endothelial syndrome presented as Cogan-Reese and Chandler's syndrome. (8795735)
1996
27
On the pathology of the iridocorneal-endothelial syndrome: the ultrastructural appearances of 'subtotal-ice'. (7556740)
1995
28
Immunohistochemical pathology of the corneal endothelium in iridocorneal endothelial syndrome. (7706030)
1995
29
Bilateral iridocorneal endothelial syndrome. (7600821)
1995
30
Herpes simplex virus in iridocorneal endothelial syndrome. (7575245)
1995
31
Management of iridocorneal endothelial syndrome. (19920569)
1994
32
Corneal endothelial cell abnormalities in an early stage of the iridocorneal endothelial syndrome. (7918291)
1994
33
Bilateral iridocorneal endothelial syndrome: case report and review of the literature. (7924340)
1994
34
Detection of herpes simplex viral DNA in the iridocorneal endothelial syndrome. (7993217)
1994
35
Prognosis for penetrating keratoplasty in iridocorneal endothelial syndrome. (8494813)
1993
36
Differential diagnosis of iridocorneal endothelial syndrome and posterior polymorphous endothelial dystrophy. (8218068)
1993
37
On the morphology of cells of posterior cornea in the iridocorneal endothelial syndrome. (2055030)
1991
38
Distinguishing features of the iridocorneal endothelial syndrome and posterior polymorphous dystrophy: value of endothelial specular microscopy. (2021586)
1991
39
5-Fluorouracil after trabeculectomy and the iridocorneal endothelial syndrome. (2023751)
1991
40
A comparison of the clinical variations of the iridocorneal endothelial syndrome. (2803093)
1989
41
Penetrating keratoplasty in the management of iridocorneal endothelial syndrome. (2647408)
1989
42
Desquamating endotheliopathy. An incipient iridocorneal endothelial syndrome? (3310985)
1987
43
Ring melanoma of the iris. Iridocorneal endothelial syndrome. (3997357)
1985
44
The corneal endothelium and Descemet's membrane in the iridocorneal endothelial syndrome. (3832533)
1985
45
Results of penetrating keratoplasty in the iridocorneal endothelial syndrome. (6383056)
1984
46
Specular microscopic appearance of the corneal endothelium in iridocorneal endothelial syndrome. (6602607)
1983
47
Decreased endothelial permeability in the iridocorneal endothelial syndrome. (7122039)
1982
48
Iridocorneal endothelial syndrome: unification of a disease spectrum. (483158)
1979
49
Proliferative endotheliopathy with iris abnormalities. The iridocorneal endothelial syndrome. (508177)
1979
50

Variations for Iridocorneal Endothelial Syndrome

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Expression for genes affiliated with Iridocorneal Endothelial Syndrome

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Search GEO for disease gene expression data for Iridocorneal Endothelial Syndrome.

Pathways for genes affiliated with Iridocorneal Endothelial Syndrome

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GO Terms for genes affiliated with Iridocorneal Endothelial Syndrome

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Sources for Iridocorneal Endothelial Syndrome

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet