MCID: IRD003
MIFTS: 21

Iridocorneal Endothelial Syndrome malady

Categories: Rare diseases, Eye diseases, Fetal diseases

Aliases & Classifications for Iridocorneal Endothelial Syndrome

About this section
Sources:
66UMLS, 46NIH Rare Diseases, 52Orphanet, 67UMLS via Orphanet, 29ICD10 via Orphanet, 38MESH via Orphanet
See all MalaCards sources

Aliases & Descriptions for Iridocorneal Endothelial Syndrome:

Name: Iridocorneal Endothelial Syndrome 46 52
Ice Syndrome 46 52
 
Ichthyosis--Cheek--Eyebrow Syndrome 66

Characteristics:

Orphanet epidemiological data:

52
iridocorneal endothelial syndrome:
Inheritance: Not applicable; Age of onset: Adult

Classifications:



External Ids:

Orphanet52 ORPHA64734
UMLS via Orphanet67 C0339285, C1096100
ICD10 via Orphanet29 H21.1
MESH via Orphanet38 D057129

Summaries for Iridocorneal Endothelial Syndrome

About this section
NIH Rare Diseases:46 Iridocorneal endothelial (ice) syndrome describes a group of eye diseases that are characterized by three main features:  visible changes in the iris (the colored part of the eye that regulates the amount of light entering the eye)  swelling of the cornea, and  the development of glaucoma (a disease that can cause severe vision loss when normal fluid inside the eye cannot drain properly) ice syndrome, is more common in women than men, most commonly diagnosed in middle age, and is usually present in only one eye. the condition is actually a grouping of three closely linked conditions: cogan-reese syndrome; chandler's syndrome; and essential (progressive) iris atrophy. the cause of ice syndrome is unknown, however there is a theory that it is triggered by a virus that leads to swelling of the cornea. while there is no way to stop the progression of the condition, treatment of the symptoms may include medication for glaucoma and corneal transplant for corneal swelling. last updated: 12/1/2015

MalaCards based summary: Iridocorneal Endothelial Syndrome, also known as ice syndrome, is related to chandler syndrome and endotheliitis. An important gene associated with Iridocorneal Endothelial Syndrome is KRT3 (Keratin 3). Affiliated tissues include endothelial and eye.

Wikipedia:69 Iridocorneal Endothelial Syndromes more...

Related Diseases for Iridocorneal Endothelial Syndrome

About this section

Diseases related to Iridocorneal Endothelial Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1chandler syndrome11.2
2endotheliitis10.9
3essential iris atrophy10.2
4cogan-reese syndrome10.1
5endothelial dystrophy10.1
6melanoma10.1
7herpes simplex10.1
8keratoconus9.9
9retinitis9.9
10glaucomatocyclitic crisis9.9

Graphical network of diseases related to Iridocorneal Endothelial Syndrome:



Diseases related to iridocorneal endothelial syndrome

Symptoms for Iridocorneal Endothelial Syndrome

About this section

Drugs & Therapeutics for Iridocorneal Endothelial Syndrome

About this section

Interventional clinical trials:

idNameStatusNCT IDPhase
1Evaluating Results of Neusidl Corneal Inserter in Descemet's Stripping Automated Endothelial Keratoplasty (DSAEK)Active, not recruitingNCT01357122Phase 4
2A Study Investigating the Safety, Tolerability, and Efficacy of Elamipretide Topical Ophthalmic Solution for the Treatment of Fuchs' Corneal Endothelial Dystrophy (FCED)RecruitingNCT02653391Phase 1, Phase 2
3Abnormalities of the Eye's Anterior Chamber, Iris, Cornea and LensCompletedNCT00001161
4Fuchs' Endothelial Dystrophy: Clinical Characteristics, Treatment Outcome, and PathologyCompletedNCT01979250
5Study of Endothelial Keratoplasty OutcomesRecruitingNCT00800111
6Outcome After Descemet Membrane Endothelial Keratoplasty (DMEK) and Ultra-thin Descemet Stripping Automated Endothelial Keratoplasty (DSAEK)RecruitingNCT02020044
7Specular Microscopy StudyRecruitingNCT02478970
8Early Experience With Descemet's Stripping Automated Endothelial KeratoplastyRecruitingNCT00744796
9The Molecular Pathogenesis of Late-onset Fuchs' Endothelial Corneal DystrophyRecruitingNCT01795001
10Assessment of Corneal Graft Attachment in Patients With Fuchs Endothelial Corneal Dystrophy Following DMEK Using Ultra-high Resolution OCTNot yet recruitingNCT02542644

Search NIH Clinical Center for Iridocorneal Endothelial Syndrome

Genetic Tests for Iridocorneal Endothelial Syndrome

About this section

Anatomical Context for Iridocorneal Endothelial Syndrome

About this section

MalaCards organs/tissues related to Iridocorneal Endothelial Syndrome:

34
Endothelial, Eye

Animal Models for Iridocorneal Endothelial Syndrome or affiliated genes

About this section

Publications for Iridocorneal Endothelial Syndrome

About this section

Articles related to Iridocorneal Endothelial Syndrome:

(show top 50)    (show all 84)
idTitleAuthorsYear
1
Cystoid macular edema associated with iridocorneal endothelial syndrome: a case report. (27585567)
2016
2
Surgical outcomes of patients with iridocorneal endothelial syndrome: a case series. (27495952)
2016
3
Diagnosis and Management of Iridocorneal Endothelial Syndrome. (26451377)
2015
4
Graft Failure and Intraocular Pressure Control After Keratoplasty in Iridocorneal Endothelial Syndrome. (26525380)
2015
5
Outcomes of Primary Trabeculectomy With Mitomycin-C in Glaucoma Secondary to Iridocorneal Endothelial Syndrome. (25943731)
2015
6
Graft failure and intraocular pressure control after keratoplasty in iridocorneal endothelial syndrome. (26032193)
2015
7
Descemet Stripping Endothelial Keratoplasty in Iridocorneal Endothelial Syndrome: Postoperative Complications and Long-Term Outcomes. (26203744)
2015
8
Concurrence of iridocorneal endothelial syndrome in a patient with glaucomatocyclitic crisis. (24790889)
2014
9
Phenotypic heterogeneity of corneal endothelium in iridocorneal endothelial syndrome by in vivo confocal microscopy. (24727634)
2014
10
Retrocorneal membrane formation after Baerveldt shunt implantation for iridocorneal endothelial syndrome. (23538633)
2013
11
Management of detached graft donor by SFa88 injection following Descemet stripping automated endothelial keratoplasty of an eye with iridocorneal endothelial syndrome and Ahmed glaucoma drainage tube. (22752650)
2012
12
Bilateral iridocorneal endothelial syndrome in a young girl with Down's syndrome. (19075416)
2009
13
Descemet's stripping with endothelial keratoplasty in iridocorneal endothelial syndrome. (18254352)
2008
14
Coexistence of unilateral iridocorneal endothelial syndrome and sensorineural deafness. (17641715)
2007
15
Reduced corneal swelling and deswelling response in the iridocorneal endothelial syndrome. (17041320)
2006
16
Ultrasound biomicroscopy of Chinese eyes with iridocorneal endothelial syndrome. (16361670)
2006
17
Macular edema and iridocorneal endothelial syndrome: a case report. (15725892)
2005
18
Features of the iridocorneal endothelial syndrome on confocal microscopy. (15778613)
2005
19
Long-term surgical outcomes of patients with glaucoma secondary to the iridocorneal endothelial syndrome. (11581050)
2001
20
Iridocorneal endothelial syndrome in Thai patients: clinical variations. (10676783)
2000
21
Outcome of trabeculectomy with mitomycin-C in the iridocorneal endothelial syndrome. (10690828)
2000
22
Long-term outcome of aqueous shunt surgery in ten patients with iridocorneal endothelial syndrome. (10328409)
1999
23
Confocal microscopy in the iridocorneal endothelial syndrome. (10340979)
1999
24
The contralateral corneal endothelium in the iridocorneal endothelial syndrome. (9006423)
1997
25
The histopathology of the iridocorneal-endothelial syndrome. (8907380)
1996
26
Bilateral iridocorneal endothelial syndrome presented as Cogan-Reese and Chandler's syndrome. (8795735)
1996
27
Herpes simplex virus in iridocorneal endothelial syndrome. (7575245)
1995
28
Descemet's membrane in the iridocorneal-endothelial syndrome: morphology and composition. (7556496)
1995
29
Pathology of the iridocorneal-endothelial syndrome. The ICE-cell. (7499082)
1995
30
Corneal endothelial cell abnormalities in an early stage of the iridocorneal endothelial syndrome. (7918291)
1994
31
Bilateral iridocorneal endothelial syndrome: case report and review of the literature. (7924340)
1994
32
Detection of herpes simplex viral DNA in the iridocorneal endothelial syndrome. (7993217)
1994
33
Management of iridocorneal endothelial syndrome. (19920569)
1994
34
Prognosis for penetrating keratoplasty in iridocorneal endothelial syndrome. (8494813)
1993
35
Differential diagnosis of iridocorneal endothelial syndrome and posterior polymorphous endothelial dystrophy. (8218068)
1993
36
On the morphology of cells of posterior cornea in the iridocorneal endothelial syndrome. (2055030)
1991
37
Distinguishing features of the iridocorneal endothelial syndrome and posterior polymorphous dystrophy: value of endothelial specular microscopy. (2021586)
1991
38
A comparison of the clinical variations of the iridocorneal endothelial syndrome. (2803093)
1989
39
Penetrating keratoplasty in the management of iridocorneal endothelial syndrome. (2647408)
1989
40
Desquamating endotheliopathy. An incipient iridocorneal endothelial syndrome? (3310985)
1987
41
Iridocorneal endothelial syndrome with contralateral guttate endothelial dystrophy. A light and electron microscopic study. (3498920)
1987
42
Clinical, electron microscopic, and immunohistochemical study of the corneal endothelium and Descemet's membrane in the iridocorneal endothelial syndrome. (2417484)
1986
43
Ring melanoma of the iris. Iridocorneal endothelial syndrome. (3997357)
1985
44
Results of penetrating keratoplasty in the iridocorneal endothelial syndrome. (6383056)
1984
45
The contralateral eye in the iridocorneal endothelial syndrome. (6472826)
1984
46
Axenfeld-Rieger syndrome: a theory of mechanism and distinctions from the iridocorneal endothelial syndrome. (6676983)
1983
47
Specular microscopic appearance of the corneal endothelium in iridocorneal endothelial syndrome. (6602607)
1983
48
Partial corneal involvement in the iridocorneal endothelial syndrome. (7180916)
1982
49
Iridocorneal endothelial syndrome: unification of a disease spectrum. (483158)
1979
50
Proliferative endotheliopathy with iris abnormalities. The iridocorneal endothelial syndrome. (508177)
1979

Variations for Iridocorneal Endothelial Syndrome

About this section

Expression for genes affiliated with Iridocorneal Endothelial Syndrome

About this section
Search GEO for disease gene expression data for Iridocorneal Endothelial Syndrome.

Pathways for genes affiliated with Iridocorneal Endothelial Syndrome

About this section

GO Terms for genes affiliated with Iridocorneal Endothelial Syndrome

About this section

Sources for Iridocorneal Endothelial Syndrome

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet