MCID: IRD003
MIFTS: 24

Iridocorneal Endothelial Syndrome malady

Rare diseases, Eye diseases, Fetal diseases categories
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Summaries for Iridocorneal Endothelial Syndrome

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NIH Rare Diseases:42 Iridocorneal endothelial (ice) syndrome describes a group of eye diseases that are characterized by three main features:  visible changes in the iris (the colored part of the eye that regulates the amount of light entering the eye)  swelling of the cornea, and  the development of glaucoma (a disease that can cause severe vision loss when normal fluid inside the eye cannot drain properly) ice syndrome, is more common in women than men, most commonly diagnosed in middle age, and is usually present in only one eye. the condition is actually a grouping of three closely linked conditions: cogan-reese syndrome; chandler's syndrome; and essential (progressive) iris atrophy. the cause of ice syndrome is unknown. while there is no way to stop the progression of the condition, treatment of the symptoms may include medication for glaucoma and corneal transplant for corneal swelling.  last updated: 12/1/2011

MalaCards based summary: Iridocorneal Endothelial Syndrome, also known as ice syndrome, is related to endotheliitis and herpes simplex. Affiliated tissues include endothelial and eye.

Wikipedia:65 Iridocorneal endothelial or ICE syndrome is a spectrum of conditions of the eye, where the inner layer... more...

Aliases & Classifications for Iridocorneal Endothelial Syndrome

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Sources:
42NIH Rare Diseases, 48Orphanet, 62UMLS, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet
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Iridocorneal Endothelial Syndrome, Aliases & Descriptions:

Name: Iridocorneal Endothelial Syndrome 42 48
Ice Syndrome 42 48
 
Ichthyosis--Cheek--Eyebrow Syndrome 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Fetal diseases
Anatomical: Eye diseases


Characteristics (Orphanet epidemiological data):

48
iridocorneal endothelial syndrome:
Inheritance: Sporadic; Age of onset: Adulthood


External Ids:

MESH via Orphanet35 D057129
ICD10 via Orphanet26 H21.1
UMLS via Orphanet63 C0339285, C1096100

Related Diseases for Iridocorneal Endothelial Syndrome

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Diseases related to Iridocorneal Endothelial Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1endotheliitis11.2
2herpes simplex10.4
3melanoma10.4
4axenfeld-rieger syndrome10.2
5glaucomatocyclitic crisis10.2
6cogan-reese syndrome10.2
7chandler syndrome10.0
8essential iris atrophy10.0

Graphical network of diseases related to Iridocorneal Endothelial Syndrome:



Diseases related to iridocorneal endothelial syndrome

Symptoms for Iridocorneal Endothelial Syndrome

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Drugs & Therapeutics for Iridocorneal Endothelial Syndrome

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Drug clinical trials:

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Search NIH Clinical Center for Iridocorneal Endothelial Syndrome

Genetic Tests for Iridocorneal Endothelial Syndrome

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Anatomical Context for Iridocorneal Endothelial Syndrome

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MalaCards organs/tissues related to Iridocorneal Endothelial Syndrome:

32
Endothelial, Eye

Animal Models for Iridocorneal Endothelial Syndrome or affiliated genes

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Publications for Iridocorneal Endothelial Syndrome

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Articles related to Iridocorneal Endothelial Syndrome:

(show top 50)    (show all 72)
idTitleAuthorsYear
1
Phenotypic heterogeneity of corneal endothelium in iridocorneal endothelial syndrome by in vivo confocal microscopy. (24727634)
2014
2
Iridocorneal endothelial syndrome. (24407828)
2014
3
Iridocorneal endothelial syndrome. (24906259)
2014
4
Concurrence of iridocorneal endothelial syndrome in a patient with glaucomatocyclitic crisis. (24790889)
2014
5
Retrocorneal membrane formation after Baerveldt shunt implantation for iridocorneal endothelial syndrome. (23538633)
2013
6
Intracameral injection of tissue plasminogen activator to treat severe postoperative fibrinous reaction in iridocorneal endothelial syndrome. (24109245)
2013
7
Management of detached graft donor by SFa88 injection following Descemet stripping automated endothelial keratoplasty of an eye with iridocorneal endothelial syndrome and Ahmed glaucoma drainage tube. (22752650)
2012
8
Iridocorneal endothelial syndrome masquerading as iris melanoma in 71 cases. (21482858)
2011
9
Iridocorneal endothelial syndrome in a 16-year-old. (20616751)
2011
10
Bilateral iridocorneal endothelial syndrome in a young girl with Down's syndrome. (19075416)
2009
11
Deep lamellar endothelial keratoplasty for iridocorneal endothelial syndrome in phakic eyes. (19139335)
2009
12
Descemet's stripping with endothelial keratoplasty in iridocorneal endothelial syndrome. (18254352)
2008
13
Descemet stripping with endothelial keratoplasty for treatment of iridocorneal endothelial syndrome. (17457204)
2007
14
Iridocorneal endothelial syndrome in a child. (17022165)
2006
15
Reduced corneal swelling and deswelling response in the iridocorneal endothelial syndrome. (17041320)
2006
16
Macular edema and iridocorneal endothelial syndrome: a case report. (15725892)
2005
17
Features of the iridocorneal endothelial syndrome on confocal microscopy. (15778613)
2005
18
Long-term surgical outcomes of patients with glaucoma secondary to the iridocorneal endothelial syndrome. (11581050)
2001
19
Iridocorneal endothelial syndrome in Thai patients: clinical variations. (10676783)
2000
20
Long-term outcome of aqueous shunt surgery in ten patients with iridocorneal endothelial syndrome. (10328409)
1999
21
The contralateral corneal endothelium in the iridocorneal endothelial syndrome. (9006423)
1997
22
Endothelial metaplasia in the iridocorneal endothelial syndrome. (9286281)
1997
23
The histopathology of the iridocorneal-endothelial syndrome. (8907380)
1996
24
Bilateral iridocorneal endothelial syndrome presented as Cogan-Reese and Chandler's syndrome. (8795735)
1996
25
On the pathology of the iridocorneal-endothelial syndrome: the ultrastructural appearances of 'subtotal-ice'. (7556740)
1995
26
Immunohistochemical pathology of the corneal endothelium in iridocorneal endothelial syndrome. (7706030)
1995
27
Bilateral iridocorneal endothelial syndrome. (7600821)
1995
28
Herpes simplex virus in iridocorneal endothelial syndrome. (7575245)
1995
29
Descemet's membrane in the iridocorneal-endothelial syndrome: morphology and composition. (7556496)
1995
30
Management of iridocorneal endothelial syndrome. (19920569)
1994
31
Corneal endothelial cell abnormalities in an early stage of the iridocorneal endothelial syndrome. (7918291)
1994
32
Bilateral iridocorneal endothelial syndrome: case report and review of the literature. (7924340)
1994
33
Detection of herpes simplex viral DNA in the iridocorneal endothelial syndrome. (7993217)
1994
34
Prognosis for penetrating keratoplasty in iridocorneal endothelial syndrome. (8494813)
1993
35
Differential diagnosis of iridocorneal endothelial syndrome and posterior polymorphous endothelial dystrophy. (8218068)
1993
36
On the morphology of cells of posterior cornea in the iridocorneal endothelial syndrome. (2055030)
1991
37
Distinguishing features of the iridocorneal endothelial syndrome and posterior polymorphous dystrophy: value of endothelial specular microscopy. (2021586)
1991
38
5-Fluorouracil after trabeculectomy and the iridocorneal endothelial syndrome. (2023751)
1991
39
A comparison of the clinical variations of the iridocorneal endothelial syndrome. (2803093)
1989
40
Penetrating keratoplasty in the management of iridocorneal endothelial syndrome. (2647408)
1989
41
Desquamating endotheliopathy. An incipient iridocorneal endothelial syndrome? (3310985)
1987
42
Iridocorneal endothelial syndrome with contralateral guttate endothelial dystrophy. A light and electron microscopic study. (3498920)
1987
43
Clinical, electron microscopic, and immunohistochemical study of the corneal endothelium and Descemet's membrane in the iridocorneal endothelial syndrome. (2417484)
1986
44
Ring melanoma of the iris. Iridocorneal endothelial syndrome. (3997357)
1985
45
The corneal endothelium and Descemet's membrane in the iridocorneal endothelial syndrome. (3832533)
1985
46
Results of penetrating keratoplasty in the iridocorneal endothelial syndrome. (6383056)
1984
47
Specular microscopic appearance of the corneal endothelium in iridocorneal endothelial syndrome. (6602607)
1983
48
Decreased endothelial permeability in the iridocorneal endothelial syndrome. (7122039)
1982
49
Iridocorneal endothelial syndrome: unification of a disease spectrum. (483158)
1979
50
Proliferative endotheliopathy with iris abnormalities. The iridocorneal endothelial syndrome. (508177)
1979

Variations for Iridocorneal Endothelial Syndrome

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Expression for genes affiliated with Iridocorneal Endothelial Syndrome

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Search GEO for disease gene expression data for Iridocorneal Endothelial Syndrome.

Pathways for genes affiliated with Iridocorneal Endothelial Syndrome

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Compounds for genes affiliated with Iridocorneal Endothelial Syndrome

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GO Terms for genes affiliated with Iridocorneal Endothelial Syndrome

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Products for genes affiliated with Iridocorneal Endothelial Syndrome

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Sources for Iridocorneal Endothelial Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet