Iridocorneal Endothelial Syndrome malady

NIH Rare Diseases: Iridocorneal endothelial (ICE) syndrome describes a group of eye diseases that are characterized by three main features:  Visible changes in the iris (the colored part of the eye that regulates the amount of light entering the eye)  Swelling of the cornea, and  The development of glaucoma (a disease that can cause severe vision loss when normal fluid inside the eye cannot drain properly) ICE syndrome, is more common in women than men, most commonly diagnosed in middle age, and is usually present in only one eye. The condition is actually a grouping of three closely linked conditions: Cogan-Reese syndrome; Chandler's syndrome; and essential (progressive) iris atrophy. The cause of ICE syndrome is unknown. While there is no way to stop the progression of the condition, treatment of the symptoms may include medication for glaucoma and corneal transplant for corneal swelling. ³⁰

MalaCards: Iridocorneal Endothelial Syndrome, also known as ice syndrome, is related to chandler syndrome. An important gene associated with Iridocorneal Endothelial Syndrome is KRT3 (keratin 3). Affiliated tissues include endothelial.

Wikipedia: Iridocorneal endothelial or ICE syndrome is a spectrum of conditions of the eye, where the inner layer...⁴⁴ more...

iridocorneal endothelial syndrome 30 ice syndrome 30

Diseases related to iridocorneal endothelial syndrome by text searches and GeneDecks gene sharing:

id	Related Disease	Score	Top Affiliating Genes
1	chandler syndrome	5.2

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to iridocorneal endothelial syndrome:

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Articles related to iridocorneal endothelial syndrome:

id	Title	Authors	Year	Affiliating Genes
1	Pathology of the iridocorneal-endothelial syndrome. The ICE-cell. (7499082)	Levy S.G.... Moss J.	1995	KRT3

Genes related to iridocorneal endothelial syndrome according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	KRT3	keratin 3	11.0	Publications, Disorders