MCID: IRD003
MIFTS: 19

Iridocorneal Endothelial Syndrome malady

Eye diseases, Fetal diseases categories

Summaries for Iridocorneal Endothelial Syndrome

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Sources:
42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Iridocorneal endothelial (ice) syndrome describes a group of eye diseases that are characterized by three main features:  visible changes in the iris (the colored part of the eye that regulates the amount of light entering the eye)  swelling of the cornea, and  the development of glaucoma (a disease that can cause severe vision loss when normal fluid inside the eye cannot drain properly) ice syndrome, is more common in women than men, most commonly diagnosed in middle age, and is usually present in only one eye. the condition is actually a grouping of three closely linked conditions: cogan-reese syndrome; chandler's syndrome; and essential (progressive) iris atrophy. the cause of ice syndrome is unknown. while there is no way to stop the progression of the condition, treatment of the symptoms may include medication for glaucoma and corneal transplant for corneal swelling.  last updated: 12/1/2011

MalaCards: Iridocorneal Endothelial Syndrome, also known as ice syndrome, is related to ichthyosis cheek eyebrow syndrome and glaucoma. An important gene associated with Iridocorneal Endothelial Syndrome is KRT3 (keratin 3). Affiliated tissues include endothelial and eye.

Wikipedia:63 Iridocorneal endothelial or ICE syndrome is a spectrum of conditions of the eye, where the inner layer... more...

Aliases & Classifications for Iridocorneal Endothelial Syndrome

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Sources:
42NIH Rare Diseases, 48Orphanet, 60UMLS, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases
Anatomical: Eye diseases


Characteristics (Orphanet epidemiological data):

48
iridocorneal endothelial syndrome:
Inheritance: Sporadic; Age of onset: Adulthood


Aliases & Descriptions:

iridocorneal endothelial syndrome 42 48
ice syndrome 42 48
ichthyosis--cheek--eyebrow syndrome 60


External Ids:

MESH via Orphanet35 D057129
ICD10 via Orphanet26 H21.1
SNOMED-CT via Orphanet57 129623003, 231936006
UMLS via Orphanet61 C0339285, C1096100

Related Diseases for Iridocorneal Endothelial Syndrome

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17GeneCards, 18GeneDecks
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Diseases related to Iridocorneal Endothelial Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1ichthyosis cheek eyebrow syndrome10.6
2glaucoma10.4
3herpes simplex10.3
4melanoma10.3
5axenfeld-rieger syndrome10.2
6chandler syndrome9.9
7essential iris atrophy9.9

Graphical network of diseases related to Iridocorneal Endothelial Syndrome:



Diseases related to iridocorneal endothelial syndrome

Clinical Features for Iridocorneal Endothelial Syndrome

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Drugs & Therapeutics for Iridocorneal Endothelial Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Iridocorneal Endothelial Syndrome

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Anatomical Context for Iridocorneal Endothelial Syndrome

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32MalaCards
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MalaCards organs/tissues related to Iridocorneal Endothelial Syndrome:

32
Endothelial, Eye

Animal Models for Iridocorneal Endothelial Syndrome or affiliated genes

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Publications for Iridocorneal Endothelial Syndrome

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Genetic Variations for Iridocorneal Endothelial Syndrome

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Expression for genes affiliated with Iridocorneal Endothelial Syndrome

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Iridocorneal Endothelial Syndrome

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Pathways for genes affiliated with Iridocorneal Endothelial Syndrome

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Compounds for genes affiliated with Iridocorneal Endothelial Syndrome

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GO Terms for genes affiliated with Iridocorneal Endothelial Syndrome

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Products for genes affiliated with Iridocorneal Endothelial Syndrome

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Iridocorneal Endothelial Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet