MCID: IRD003
MIFTS: 25

Iridocorneal Endothelial Syndrome malady

Rare diseases, Eye diseases, Fetal diseases categories
Download this MalaCard

Summaries for Iridocorneal Endothelial Syndrome

About this section
Sources:
43NIH Rare Diseases, 65Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard
NIH Rare Diseases:43 Iridocorneal endothelial (ice) syndrome describes a group of eye diseases that are characterized by three main features:  visible changes in the iris (the colored part of the eye that regulates the amount of light entering the eye)  swelling of the cornea, and  the development of glaucoma (a disease that can cause severe vision loss when normal fluid inside the eye cannot drain properly) ice syndrome, is more common in women than men, most commonly diagnosed in middle age, and is usually present in only one eye. the condition is actually a grouping of three closely linked conditions: cogan-reese syndrome; chandler's syndrome; and essential (progressive) iris atrophy. the cause of ice syndrome is unknown. while there is no way to stop the progression of the condition, treatment of the symptoms may include medication for glaucoma and corneal transplant for corneal swelling.  last updated: 12/1/2011

MalaCards: Iridocorneal Endothelial Syndrome, also known as ice syndrome, is related to endotheliitis and glaucoma. Affiliated tissues include endothelial and eye.

Wikipedia:65 Iridocorneal endothelial or ICE syndrome is a spectrum of conditions of the eye, where the inner layer... more...

Aliases & Classifications for Iridocorneal Endothelial Syndrome

About this section
Sources:
43NIH Rare Diseases, 49Orphanet, 62UMLS, 36MESH via Orphanet, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Fetal diseases
Anatomical: Eye diseases


Characteristics (Orphanet epidemiological data):

49
iridocorneal endothelial syndrome:
Inheritance: Sporadic; Age of onset: Adulthood


Aliases & Descriptions:

iridocorneal endothelial syndrome 43 49
ice syndrome 43 49
ichthyosis--cheek--eyebrow syndrome 62


External Ids:

MESH via Orphanet36 D057129
ICD10 via Orphanet26 H21.1
SNOMED-CT via Orphanet59 129623003, 231936006
UMLS via Orphanet63 C0339285, C1096100

Related Diseases for Iridocorneal Endothelial Syndrome

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Iridocorneal Endothelial Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1endotheliitis11.1
2glaucoma10.5
3herpes simplex10.4
4melanoma10.4
5axenfeld-rieger syndrome10.2
6chandler syndrome10.0
7essential iris atrophy10.0

Graphical network of diseases related to Iridocorneal Endothelial Syndrome:



Diseases related to iridocorneal endothelial syndrome

Symptoms for Iridocorneal Endothelial Syndrome

About this section

Drugs & Therapeutics for Iridocorneal Endothelial Syndrome

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials
See all sources

Drug clinical trials:

Search ClinicalTrials for Iridocorneal Endothelial Syndrome

Search NIH Clinical Center for Iridocorneal Endothelial Syndrome

Genetic Tests for Iridocorneal Endothelial Syndrome

About this section

Anatomical Context for Iridocorneal Endothelial Syndrome

About this section
Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Iridocorneal Endothelial Syndrome:

33
Endothelial, Eye

Animal Models for Iridocorneal Endothelial Syndrome or affiliated genes

About this section

Publications for Iridocorneal Endothelial Syndrome

About this section
Sources:
52PubMed
See all sources

Articles related to Iridocorneal Endothelial Syndrome:

(show top 50)    (show all 68)
idTitleAuthorsYear
1
Iridocorneal endothelial syndrome. (24407828)
2014
2
Retrocorneal membrane formation after Baerveldt shunt implantation for iridocorneal endothelial syndrome. (23538633)
2013
3
Intracameral injection of tissue plasminogen activator to treat severe postoperative fibrinous reaction in iridocorneal endothelial syndrome. (24109245)
2013
4
Management of detached graft donor by SFa88 injection following Descemet stripping automated endothelial keratoplasty of an eye with iridocorneal endothelial syndrome and Ahmed glaucoma drainage tube. (22752650)
2012
5
Iridocorneal endothelial syndrome masquerading as iris melanoma in 71 cases. (21482858)
2011
6
Iridocorneal endothelial syndrome in a 16-year-old. (20616751)
2011
7
Bilateral iridocorneal endothelial syndrome in a young girl with Down's syndrome. (19075416)
2009
8
Deep lamellar endothelial keratoplasty for iridocorneal endothelial syndrome in phakic eyes. (19139335)
2009
9
Descemet's stripping with endothelial keratoplasty in iridocorneal endothelial syndrome. (18254352)
2008
10
Descemet stripping with endothelial keratoplasty for treatment of iridocorneal endothelial syndrome. (17457204)
2007
11
Iridocorneal endothelial syndrome in a child. (17022165)
2006
12
Reduced corneal swelling and deswelling response in the iridocorneal endothelial syndrome. (17041320)
2006
13
Macular edema and iridocorneal endothelial syndrome: a case report. (15725892)
2005
14
Features of the iridocorneal endothelial syndrome on confocal microscopy. (15778613)
2005
15
Long-term surgical outcomes of patients with glaucoma secondary to the iridocorneal endothelial syndrome. (11581050)
2001
16
Iridocorneal endothelial syndrome in Thai patients: clinical variations. (10676783)
2000
17
Long-term outcome of aqueous shunt surgery in ten patients with iridocorneal endothelial syndrome. (10328409)
1999
18
Confocal microscopy in the iridocorneal endothelial syndrome. (10340979)
1999
19
The contralateral corneal endothelium in the iridocorneal endothelial syndrome. (9006423)
1997
20
Endothelial metaplasia in the iridocorneal endothelial syndrome. (9286281)
1997
21
The histopathology of the iridocorneal-endothelial syndrome. (8907380)
1996
22
Bilateral iridocorneal endothelial syndrome presented as Cogan-Reese and Chandler's syndrome. (8795735)
1996
23
On the pathology of the iridocorneal-endothelial syndrome: the ultrastructural appearances of 'subtotal-ice'. (7556740)
1995
24
Immunohistochemical pathology of the corneal endothelium in iridocorneal endothelial syndrome. (7706030)
1995
25
Bilateral iridocorneal endothelial syndrome. (7600821)
1995
26
Herpes simplex virus in iridocorneal endothelial syndrome. (7575245)
1995
27
Descemet's membrane in the iridocorneal-endothelial syndrome: morphology and composition. (7556496)
1995
28
Management of iridocorneal endothelial syndrome. (19920569)
1994
29
Corneal endothelial cell abnormalities in an early stage of the iridocorneal endothelial syndrome. (7918291)
1994
30
Bilateral iridocorneal endothelial syndrome: case report and review of the literature. (7924340)
1994
31
Detection of herpes simplex viral DNA in the iridocorneal endothelial syndrome. (7993217)
1994
32
Prognosis for penetrating keratoplasty in iridocorneal endothelial syndrome. (8494813)
1993
33
Differential diagnosis of iridocorneal endothelial syndrome and posterior polymorphous endothelial dystrophy. (8218068)
1993
34
Cytokeratin expression in corneal endothelium in the iridocorneal endothelial syndrome. (1281463)
1992
35
Progression and regression of partial corneal involvement in the iridocorneal endothelial syndrome. (1642292)
1992
36
On the morphology of cells of posterior cornea in the iridocorneal endothelial syndrome. (2055030)
1991
37
Distinguishing features of the iridocorneal endothelial syndrome and posterior polymorphous dystrophy: value of endothelial specular microscopy. (2021586)
1991
38
5-Fluorouracil after trabeculectomy and the iridocorneal endothelial syndrome. (2023751)
1991
39
A comparison of the clinical variations of the iridocorneal endothelial syndrome. (2803093)
1989
40
Penetrating keratoplasty in the management of iridocorneal endothelial syndrome. (2647408)
1989
41
Desquamating endotheliopathy. An incipient iridocorneal endothelial syndrome? (3310985)
1987
42
Iridocorneal endothelial syndrome with contralateral guttate endothelial dystrophy. A light and electron microscopic study. (3498920)
1987
43
Clinical, electron microscopic, and immunohistochemical study of the corneal endothelium and Descemet's membrane in the iridocorneal endothelial syndrome. (2417484)
1986
44
Ring melanoma of the iris. Iridocorneal endothelial syndrome. (3997357)
1985
45
The corneal endothelium and Descemet's membrane in the iridocorneal endothelial syndrome. (3832533)
1985
46
Results of penetrating keratoplasty in the iridocorneal endothelial syndrome. (6383056)
1984
47
Specular microscopic appearance of the corneal endothelium in iridocorneal endothelial syndrome. (6602607)
1983
48
Decreased endothelial permeability in the iridocorneal endothelial syndrome. (7122039)
1982
49
Iridocorneal endothelial syndrome: unification of a disease spectrum. (483158)
1979
50
Proliferative endotheliopathy with iris abnormalities. The iridocorneal endothelial syndrome. (508177)
1979

Variations for Iridocorneal Endothelial Syndrome

About this section

Expression for genes affiliated with Iridocorneal Endothelial Syndrome

About this section
Sources:
15Gene Expression Omnibus DataSets
See all sources

Search GEO for disease gene expression data for Iridocorneal Endothelial Syndrome.

Pathways for genes affiliated with Iridocorneal Endothelial Syndrome

About this section

Compounds for genes affiliated with Iridocorneal Endothelial Syndrome

About this section

GO Terms for genes affiliated with Iridocorneal Endothelial Syndrome

About this section

Products for genes affiliated with Iridocorneal Endothelial Syndrome

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Iridocorneal Endothelial Syndrome

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet