MCID: IRD003
MIFTS: 26

Iridocorneal Endothelial Syndrome

Categories: Rare diseases, Eye diseases, Fetal diseases

Aliases & Classifications for Iridocorneal Endothelial Syndrome

MalaCards integrated aliases for Iridocorneal Endothelial Syndrome:

Name: Iridocorneal Endothelial Syndrome 49 55
Ice Syndrome 49 55
Ichthyosis--Cheek--Eyebrow Syndrome 69

Characteristics:

Orphanet epidemiological data:

55
iridocorneal endothelial syndrome
Inheritance: Not applicable; Age of onset: Adult;

Classifications:



External Ids:

Orphanet 55 ORPHA64734
MESH via Orphanet 42 D057129
UMLS via Orphanet 70 C1096100 C0339285
ICD10 via Orphanet 33 H21.1
UMLS 69 C1840283

Summaries for Iridocorneal Endothelial Syndrome

NIH Rare Diseases : 49 Iridocorneal endothelial (ICE) syndrome describes a group of eye diseases that are characterized by three main features:  Visible changes in the iris (the colored part of the eye that regulates the amount of light entering the eye)  Swelling of the cornea, and  The development of glaucoma (a disease that can cause severe vision loss when normal fluid inside the eye cannot drain properly) ICE syndrome, is more common in women than men, most commonly diagnosed in middle age, and is usually present in only one eye. The condition is actually a grouping of three closely linked conditions: Cogan-Reese syndrome; Chandler's syndrome; and essential (progressive) iris atrophy. The cause of ICE syndrome is unknown, however there is a theory that it is triggered by a virus that leads to swelling of the cornea. While there is no way to stop the progression of the condition, treatment of the symptoms may include medication for glaucoma and corneal transplant for corneal swelling. Last updated: 12/1/2015

MalaCards based summary : Iridocorneal Endothelial Syndrome, also known as ice syndrome, is related to corneal endothelial dystrophy and endotheliitis. An important gene associated with Iridocorneal Endothelial Syndrome is KRT3 (Keratin 3). The drugs Ophthalmic Solutions and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include endothelial and eye.

Related Diseases for Iridocorneal Endothelial Syndrome

Diseases related to Iridocorneal Endothelial Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
# Related Disease Score Top Affiliating Genes
1 corneal endothelial dystrophy 11.2
2 endotheliitis 10.9
3 hydrops, lactic acidosis, and sideroblastic anemia 10.0
4 melanoma 10.0
5 macular retinal edema 10.0
6 herpes simplex 10.0
7 glaucomatocyclitic crisis 9.9
8 branchiootic syndrome 1 9.9
9 keratoconus 9.9
10 axenfeld-rieger syndrome 9.9
11 retinitis 9.9

Graphical network of the top 20 diseases related to Iridocorneal Endothelial Syndrome:



Diseases related to Iridocorneal Endothelial Syndrome

Symptoms & Phenotypes for Iridocorneal Endothelial Syndrome

Drugs & Therapeutics for Iridocorneal Endothelial Syndrome

Drugs for Iridocorneal Endothelial Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Ophthalmic Solutions Phase 1, Phase 2
2 Pharmaceutical Solutions Phase 1, Phase 2

Interventional clinical trials:

(show all 11)

# Name Status NCT ID Phase Drugs
1 Evaluating Results of Neusidl Corneal Inserter in Descemet's Stripping Automated Endothelial Keratoplasty (DSAEK) Unknown status NCT01357122 Phase 4
2 A Study Investigating the Safety, Tolerability, and Efficacy of Elamipretide Topical Ophthalmic Solution for the Treatment of Fuchs' Corneal Endothelial Dystrophy (FCED) Active, not recruiting NCT02653391 Phase 1, Phase 2 Elamipretide 1.0% Ophthalmic Solution;Elamipretide 3.0% Ophthalmic Solution
3 Outcome After Descemet Membrane Endothelial Keratoplasty (DMEK) and Ultra-thin Descemet Stripping Automated Endothelial Keratoplasty (DSAEK) Unknown status NCT02020044
4 The Molecular Pathogenesis of Late-onset Fuchs' Endothelial Corneal Dystrophy Unknown status NCT01795001
5 Early Experience With Descemet's Stripping Automated Endothelial Keratoplasty Unknown status NCT00744796
6 Abnormalities of the Eye's Anterior Chamber, Iris, Cornea and Lens Completed NCT00001161
7 Fuchs' Endothelial Dystrophy: Clinical Characteristics, Treatment Outcome, and Pathology Completed NCT01979250
8 Zhongshan Iridocorneal Endothelial Syndrome Study (ICEs) Recruiting NCT03270761
9 Study of Endothelial Keratoplasty Outcomes Recruiting NCT00800111
10 Assessment of Corneal Graft Attachment in Patients With Fuchs Endothelial Corneal Dystrophy Following DMEK Using Ultra-high Resolution OCT Recruiting NCT02542644
11 Specular Microscopy Study Withdrawn NCT02478970

Search NIH Clinical Center for Iridocorneal Endothelial Syndrome

Genetic Tests for Iridocorneal Endothelial Syndrome

Anatomical Context for Iridocorneal Endothelial Syndrome

MalaCards organs/tissues related to Iridocorneal Endothelial Syndrome:

38
Endothelial, Eye

Publications for Iridocorneal Endothelial Syndrome

Articles related to Iridocorneal Endothelial Syndrome:

(show top 50) (show all 89)
# Title Authors Year
1
The Iridocorneal Endothelial Syndrome. ( 29331589 )
2018
2
Glaucoma associated with iridocorneal endothelial syndrome in 203 Indian subjects. ( 28282413 )
2017
3
Clinical outcome of Descemet stripping automated endothelial keratoplasty in 18 cases with iridocorneal endothelial syndrome. ( 29243737 )
2017
4
Unique variations and characteristics of iridocorneal endothelial syndrome in China: a case series of 58 patients. ( 28993974 )
2017
5
Iridocorneal Endothelial Syndrome Presenting With Large Diurnal Intraocular Pressure Fluctuation. ( 27977477 )
2016
6
Surgical outcomes of patients with iridocorneal endothelial syndrome: a case series. ( 27495952 )
2016
7
Post Filtering Surgery Globe Massage-induced Keratoconus in an Eye with Iridocorneal Endothelial Syndrome: A Case Report and Literature Brief Review. ( 27621792 )
2016
8
Cystoid macular edema associated with iridocorneal endothelial syndrome: a case report. ( 27585567 )
2016
9
Trabeculectomy with Mitomycin-C in Patients with Iridocorneal Endothelial Syndrome: A Case Series. ( 27437260 )
2016
10
Concurrent Acute Retinal Necrosis in a Patient With Iridocorneal Endothelial Syndrome. ( 27362881 )
2016
11
Graft failure and intraocular pressure control after keratoplasty in iridocorneal endothelial syndrome. ( 26032193 )
2015
12
Iridocorneal Endothelial Syndrome in a 14-Year-Old Male. ( 26035422 )
2015
13
Graft Failure and Intraocular Pressure Control After Keratoplasty in Iridocorneal Endothelial Syndrome. ( 26514395 )
2015
14
Descemet Stripping Endothelial Keratoplasty in Iridocorneal Endothelial Syndrome: Postoperative Complications and Long-Term Outcomes. ( 26203744 )
2015
15
Outcomes of Primary Trabeculectomy With Mitomycin-C in Glaucoma Secondary to Iridocorneal Endothelial Syndrome. ( 25943731 )
2015
16
Diagnosis and Management of Iridocorneal Endothelial Syndrome. ( 26451377 )
2015
17
Graft Failure and Intraocular Pressure Control After Keratoplasty in Iridocorneal Endothelial Syndrome. ( 26525380 )
2015
18
Concurrence of iridocorneal endothelial syndrome in a patient with glaucomatocyclitic crisis. ( 24790889 )
2014
19
Iridocorneal endothelial syndrome. ( 24906259 )
2014
20
Iridocorneal endothelial syndrome. ( 24407828 )
2014
21
Phenotypic heterogeneity of corneal endothelium in iridocorneal endothelial syndrome by in vivo confocal microscopy. ( 24727634 )
2014
22
Retrocorneal membrane formation after Baerveldt shunt implantation for iridocorneal endothelial syndrome. ( 23538633 )
2013
23
Iridocorneal endothelial syndrome in a Chinese child. ( 24579558 )
2013
24
Intracameral injection of tissue plasminogen activator to treat severe postoperative fibrinous reaction in iridocorneal endothelial syndrome. ( 24109245 )
2013
25
Management of detached graft donor by SFa88 injection following Descemet stripping automated endothelial keratoplasty of an eye with iridocorneal endothelial syndrome and Ahmed glaucoma drainage tube. ( 22752650 )
2012
26
Clinicopathologic findings in iridocorneal endothelial syndrome and posterior polymorphous membranous dystrophy after Descemet stripping automated endothelial keratoplasty. ( 22333668 )
2012
27
Iridocorneal endothelial syndrome masquerading as iris melanoma in 71 cases. ( 21482858 )
2011
28
Iridocorneal endothelial syndrome in a 16-year-old. ( 20616751 )
2011
29
Bilateral iridocorneal endothelial syndrome in a young girl with Down's syndrome. ( 19075416 )
2009
30
Deep lamellar endothelial keratoplasty for iridocorneal endothelial syndrome in phakic eyes. ( 19139335 )
2009
31
In-vivo confocal microscopy of iridocorneal endothelial syndrome. ( 18297250 )
2009
32
Descemet's stripping with endothelial keratoplasty in iridocorneal endothelial syndrome. ( 18254352 )
2008
33
Descemet stripping with endothelial keratoplasty for treatment of iridocorneal endothelial syndrome. ( 17457204 )
2007
34
Coexistence of unilateral iridocorneal endothelial syndrome and sensorineural deafness. ( 17641715 )
2007
35
Ultrasound biomicroscopy of Chinese eyes with iridocorneal endothelial syndrome. ( 16361670 )
2006
36
Iridocorneal endothelial syndrome in a child. ( 17022165 )
2006
37
Reduced corneal swelling and deswelling response in the iridocorneal endothelial syndrome. ( 17041320 )
2006
38
Features of the iridocorneal endothelial syndrome on confocal microscopy. ( 15778613 )
2005
39
Macular edema and iridocorneal endothelial syndrome: a case report. ( 15725892 )
2005
40
Iris reconstruction with a multipiece endocapsular prosthesis in iridocorneal endothelial syndrome. ( 16412914 )
2005
41
In vivo confocal microscopic characteristics of iridocorneal endothelial syndrome. ( 15180840 )
2004
42
Bilaminar interepithelial bodies within fingerprint dystrophy-like changes in bilateral iridocorneal endothelial syndrome. ( 12642328 )
2003
43
Clinical and specular microscopic manifestations of iridocorneal endothelial syndrome. ( 11369379 )
2001
44
Posterior polymorphous membranous dystrophy with overlapping features of iridocorneal endothelial syndrome. ( 11296040 )
2001
45
Long-term surgical outcomes of patients with glaucoma secondary to the iridocorneal endothelial syndrome. ( 11581050 )
2001
46
Penetrating keratoplasty in iridocorneal endothelial syndrome. ( 11248814 )
2001
47
Iridocorneal endothelial syndrome in Thai patients: clinical variations. ( 10676783 )
2000
48
Outcome of trabeculectomy with mitomycin-C in the iridocorneal endothelial syndrome. ( 10690828 )
2000
49
Confocal microscopy in the iridocorneal endothelial syndrome. ( 10340979 )
1999
50
Pseudocapsulorrhexis in a patient with iridocorneal endothelial syndrome. ( 10088823 )
1999

Variations for Iridocorneal Endothelial Syndrome

Expression for Iridocorneal Endothelial Syndrome

Search GEO for disease gene expression data for Iridocorneal Endothelial Syndrome.

Pathways for Iridocorneal Endothelial Syndrome

GO Terms for Iridocorneal Endothelial Syndrome

Sources for Iridocorneal Endothelial Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
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29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
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35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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