MCID: IRD001
MIFTS: 41

Iridocyclitis malady

Categories: Eye diseases

Aliases & Classifications for Iridocyclitis

Summaries for Iridocyclitis

MalaCards based summary : Iridocyclitis, also known as primary iridocyclitis, is related to lens-induced iridocyclitis and gonococcal iridocyclitis. An important gene associated with Iridocyclitis is DEK (DEK Proto-Oncogene), and among its related pathways/superpathways are NF-kappaB Signaling and Influenza A. The drugs Ganciclovir and Methotrexate have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and endothelial.

Wikipedia : 71 Uveitis is the inflammation of the uvea, the pigmented layer that lies between the inner retina and the... more...

Related Diseases for Iridocyclitis

Diseases related to Iridocyclitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 122)
id Related Disease Score Top Affiliating Genes
1 lens-induced iridocyclitis 12.0
2 gonococcal iridocyclitis 11.8
3 fuchs' heterochromic uveitis 11.8
4 infectious anterior uveitis 11.4
5 phacoanaphylactic uveitis 11.2
6 anterior uveitis 11.2
7 retinal vasculitis 10.9
8 uveitis 10.5
9 arthritis 10.3
10 idiopathic anterior uveitis 10.2
11 rheumatoid arthritis 10.2
12 diabetic peripheral angiopathy 10.2 CD40LG MRAP
13 angiolipoma 10.2 CD40LG MRAP
14 primary thrombocytopenia 10.1 CD40LG MRAP
15 primary lacrimal atrophy 10.1 CD40LG MRAP
16 basilar artery occlusion 10.1 CD40LG MRAP
17 vulvovaginal candidiasis 10.1 CD40LG MRAP
18 vulvar sarcoma 10.1 CD40LG MRAP
19 hairy tongue 10.1 CD40LG MRAP
20 cataract 10.1
21 tularemia 10.1 CD40LG MRAP
22 intravascular angioleiomyoma 10.1 CD40LG MRAP
23 epididymo-orchitis 10.1 HLA-B MRAP
24 pancreatic serous cystadenoma 10.1 CD40LG MRAP
25 tonsillitis 10.1 HLA-B MRAP
26 microcystic adenoma 10.1 CD40LG TNFAIP3
27 conjunctival vascular disease 10.1 CD40LG MRAP
28 asynchronous multifocal osteogenic sarcoma 10.1 MRAP TNFRSF10B
29 epiglottitis 10.1 CYP11B1 MRAP TNFAIP3
30 osmotic diarrhea 10.1 CD40LG TNFRSF10B
31 patau syndrome 10.1 MRAP TNFRSF10B
32 anaerobic meningitis 10.0 HLA-B TNFRSF10B
33 newcastle disease 10.0 CD40LG MRAP
34 keratitis 10.0
35 chronic erythremia 10.0 CD40LG HLA-B
36 plasmodium falciparum malaria 9.9 CD40LG HLA-B MRAP
37 cryptococcosis 9.9 CD40LG HLA-B MRAP
38 herpes simplex 9.9
39 celiac disease 9.9 CD40LG HLA-B MRAP
40 disease of mental health 9.9 CD40LG HLA-B
41 acute cholangitis 9.9 CD40LG HLA-B
42 goodpasture syndrome 9.9 CD40LG HLA-B MRAP
43 vogt-koyanagi-harada disease 9.9
44 infectious posterior uveitis 9.9
45 idiopathic posterior uveitis 9.9
46 retinitis 9.8
47 anthracosis 9.8 CD40LG HLA-DPB1 MRAP
48 leprosy 9.8
49 chikungunya 9.8
50 hypopyon 9.8

Graphical network of the top 20 diseases related to Iridocyclitis:



Diseases related to Iridocyclitis

Symptoms & Phenotypes for Iridocyclitis

Drugs & Therapeutics for Iridocyclitis

Drugs for Iridocyclitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 93)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ganciclovir Approved, Investigational Phase 4 82410-32-0 3454
2
Methotrexate Approved Phase 4 1959-05-2, 59-05-2 126941
3
Certolizumab pegol Approved Phase 4 428863-50-7
4
Adalimumab Approved Phase 4,Phase 3 331731-18-1 16219006
5
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
6
leucovorin Approved, Nutraceutical Phase 4 58-05-9 54575, 6560146 143
7 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
8 Hormones Phase 4,Phase 3,Phase 2,Phase 1
9 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
10 Antirheumatic Agents Phase 4,Phase 3
11 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1
12 Anti-Infective Agents Phase 4,Phase 3,Phase 1,Phase 2
13 Antiviral Agents Phase 4,Phase 3,Phase 1,Phase 2
14 Ganciclovir triphosphate Phase 4
15 Nucleic Acid Synthesis Inhibitors Phase 4
16 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
17 Antimetabolites Phase 4
18 Antimetabolites, Antineoplastic Phase 4
19 Dermatologic Agents Phase 4
20 Folic Acid Antagonists Phase 4
21 Vitamin B Complex Phase 4
22 Adrenocorticotropic Hormone Phase 4
23 beta-endorphin Phase 4
24 Melanocyte-Stimulating Hormones Phase 4
25 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1
26 Ophthalmic Solutions Phase 4,Phase 3,Phase 2,Phase 1
27 Tetrahydrozoline Phase 4,Phase 3,Phase 2,Phase 1
28 Folate Nutraceutical Phase 4
29 Vitamin B9 Nutraceutical Phase 4
30
Methylprednisolone Approved, Vet_approved Phase 3,Phase 2,Phase 1 83-43-2 6741
31
Prednisolone Approved, Vet_approved Phase 3,Phase 2,Phase 1 50-24-8 5755
32
Difluprednate Approved Phase 3,Phase 2 23674-86-4 443936
33
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 50-02-2 5743
34
Ephedrine Approved Phase 3,Phase 1,Phase 2 299-42-3 9294
35
Pseudoephedrine Approved Phase 3,Phase 1,Phase 2 90-82-4 7028
36
Triamcinolone Approved, Vet_approved Phase 3,Phase 2 124-94-7 31307
37 Acyclovir Phase 3
38 Antiemetics Phase 3,Phase 2,Phase 1
39 Autonomic Agents Phase 3,Phase 2,Phase 1
40 Gastrointestinal Agents Phase 3,Phase 2,Phase 1
41 Methylprednisolone acetate Phase 3,Phase 2,Phase 1
42 Methylprednisolone Hemisuccinate Phase 3,Phase 2,Phase 1
43 Neuroprotective Agents Phase 3,Phase 2,Phase 1
44 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1
45 Prednisolone acetate Phase 3,Phase 2,Phase 1
46 Prednisolone hemisuccinate Phase 3,Phase 2,Phase 1
47 Prednisolone phosphate Phase 3,Phase 2,Phase 1
48 Protective Agents Phase 3,Phase 2,Phase 1
49 Antineoplastic Agents, Hormonal Phase 3,Phase 2,Phase 1
50 glucocorticoids Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 53)
id Name Status NCT ID Phase
1 Study of H.P. ACTHAR Subcutaneous Gelatin (Gel)(Highly Purified Gel Injection) in Uveitis Patients Completed NCT02764697 Phase 4
2 A Study to Assess the Effects of Certolizumab Pegol on the Reduction of Anterior Uveitis (AU) Flares in Axial Spondyloarthritis Subjects With a Documented History of AU Recruiting NCT03020992 Phase 4
3 Topical 2% Ganciclovir Eye Drop for CMV Anterior Uveitis / Endotheliitis Recruiting NCT02943057 Phase 4
4 A Study Treating Participants With Early Axial Spondyloarthritis (axSpA) Taking an Intense Treatment Approach Versus Routine Treatment Recruiting NCT02897115 Phase 4
5 Open Label Study of Acthar SQ Gel Injection in Patients With Active Anterior Uveitis Not yet recruiting NCT02769702 Phase 4
6 Methotrexate in the Treatment of Axial Spondyloarthritis Withdrawn NCT00298012 Phase 4
7 Herpetic Eye Disease Study (HEDS) I Unknown status NCT00000138 Phase 3
8 Safety and Efficacy of Difluprednate 0.05% for the Treatment of Anterior Uveitis Completed NCT01201798 Phase 3
9 A Multi-center Study to Assess the Efficacy and Safety of LX211 in Active Non-infectious Anterior Uveitis Completed NCT00404885 Phase 3
10 Study of Difluprednate Ophthalmic Emulsion in the Treatment of Uveitis Completed NCT00406887 Phase 3
11 Safety and Efficacy Study of Iontophoretic Dexamethasone Phosphate Ophthalmic Solution to Treat Non-Infectious Anterior Segment Uveitis Completed NCT01505088 Phase 3
12 Study of Difluprednate Ophthalmic Emulsion in the Treatment of Severe Uveitis Completed NCT00407056 Phase 3
13 Herpetic Eye Disease Study (HEDS) II Completed NCT00000139 Phase 3
14 Study of Difluprednate in the Treatment of Uveitis Completed NCT00501579 Phase 3
15 A Phase 3 Study to Evaluate ADX-102 Ophthalmic Solution in Subjects With Non-infectious Anterior-uveitis. Recruiting NCT03131154 Phase 3
16 Safety and Efficacy of Iontophoretic Dexamethasone Phosphate Ophthalmic Solution in Non-Infectious Anterior Uveitis Recruiting NCT02517619 Phase 3
17 Suprachoroidal Injection of CLS-TA in Subjects Non-infectious Uveitis Recruiting NCT03097315 Phase 3
18 Suprachoroidal Injection of CLS-TA in Subjects With Macular Edema Associated With Non-infectious Uveitis Recruiting NCT02595398 Phase 3
19 A Long Term Extension Study of Ixekizumab (LY2439821) in Participants With Axial Spondyloarthritis Recruiting NCT03129100 Phase 3
20 A Study of Ixekizumab (LY2439821) in Participants With Nonradiographic Axial Spondyloarthritis Recruiting NCT02757352 Phase 3
21 A Study of Ixekizumab (LY2439821) in TNF Inhibitor Experienced Participants With Radiographic Axial Spondyloarthritis Recruiting NCT02696798 Phase 3
22 A Study of Ixekizumab (LY2439821) in bDMARD-Naive Participants With Radiographic Axial Spondyloarthritis Recruiting NCT02696785 Phase 3
23 A Study of the Long-term Safety and Efficacy of Adalimumab in Subjects With Intermediate-, Posterior-, or Pan-uveitis Active, not recruiting NCT01148225 Phase 3
24 A Study of the Safety and Efficacy of a New Treatment for Non-Infectious Anterior Uveitis Terminated NCT00333996 Phase 2, Phase 3
25 Proof of Concept Study to Evaluate Safety and Efficacy of LME636 in the Treatment of Acute Anterior Uveitis Completed NCT02482129 Phase 2
26 A Safety and Efficacy Study of NS2 in Patients With Anterior Uveitis Completed NCT02406209 Phase 2
27 Exploratory Study on Topical ESBA105 in Acute Anterior Uveitis Completed NCT00823173 Phase 2
28 Safety and Efficacy Study of DSP-Visulex for the Treatment of Anterior Uveitis Completed NCT02309385 Phase 1, Phase 2
29 Study of Difluprednate Ophthalmic Emulsion in the Treatment of Uveitis Completed NCT00405496 Phase 2
30 Human Anti-Tac (Daclizumab) to Treat Juvenile Idiopathic Arthritis (JIA)-Associated Uveitis Completed NCT00130637 Phase 2
31 Topical Interferon Gamma for Macular Edema Secondary to Uveitis Completed NCT01376362 Phase 1, Phase 2
32 Safety and Efficacy Study of Iontophoresis and Dexamethasone Phosphate to Treat Anterior Uveitis Completed NCT00694135 Phase 2
33 Suprachoroidal Injection of Triamcinolone Acetonide in Subjects With Macular Edema Following Non-Infectious Uveitis Completed NCT02255032 Phase 2
34 A Phase I/IIa Study for the Treatment of Uveitis With Iontophoresis Withdrawn NCT00499551 Phase 1, Phase 2
35 Subconjunctival Sirolimus for the Treatment of Autoimmune Active Anterior Uveiti Completed NCT00876434 Phase 1
36 Subconjunctival IVIg (Gamunex-C) Injection for Corneal Neovascularization and Inflammatory Conditions Withdrawn NCT02042027 Phase 1
37 Acute Anterior Uveitis: Psychic Burden and Pain Unknown status NCT01156285
38 Clinical Outcomes of Topical Ganciclovir Treatment in Cytomegalovirus Anterior Uveitis Unknown status NCT01486693
39 Quality of Life and Visual Function in Uveitis Patients Unknown status NCT00407316 Early Phase 1
40 Etanercept: Single Blind Control Study in Ocular Manifestations of Behcet's Disease Unknown status NCT00931957
41 PEMF: an Adjunct Therapy for Anterior Uveitis Completed NCT01154010
42 Topical Administration of 0.15% Ganciclovir Gel for CMV Anterior Uveitis / Endotheliitis Completed NCT01647529
43 Retinal OCT and (mfERG) Related to Age, Sex, and the Use of Anti-inflammatory Medications Completed NCT00476593
44 Cyclosporine A in the Treatment of Juvenile Idiopathic Arthritis (JIA) Associated Chronic Anterior Uveitis Completed NCT00404482
45 Evaluation and Treatment of Patients With Inflammatory Eye Diseases Completed NCT00006188
46 Evaluation of Biological Biomarkers Diagnostic of Toxoplasmosis Uveitis Completed NCT02843438
47 Intraocular Pressure (IOP) Assessed by Dynamic Contour Tonometer (DCT) and Goldman Applanation Tonometry (GAT) Completed NCT00552019
48 Diagnostic Criteria in the Diagnosis of Spinal Spondyloarthropathies in Patients With Chronic Low Back Pain (Study P05320)(COMPLETED) Completed NCT00726765
49 Aqueous Humor Dynamics and Uveitic Glaucoma Recruiting NCT02765308
50 Ocular Sarcoidosis Open Label Trial of ACTHAR Gel Recruiting NCT02725177

Search NIH Clinical Center for Iridocyclitis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Genetic Tests for Iridocyclitis

Anatomical Context for Iridocyclitis

MalaCards organs/tissues related to Iridocyclitis:

39
Eye, Retina, Endothelial, Testes, Neutrophil, Liver, Thyroid

Publications for Iridocyclitis

Articles related to Iridocyclitis:

(show top 50) (show all 274)
id Title Authors Year
1
Anti-dense Fine Speckled 70 Autoantibodies in Japanese Children with Dermatomyositis, Localized Scleroderma, and Idiopathic Arthritis with Iridocyclitis. ( 28461535 )
2017
2
Zika virus-related hypertensive iridocyclitis. ( 26840174 )
2016
3
Fuchs' Heterochromic Iridocyclitis in an Italian Tertiary Referral Centre: Epidemiology, Clinical Features, and Prognosis. ( 27781126 )
2016
4
Phacoemulsification Versus Manual Small Incision Cataract Surgery in Patients With Fuchs Heterochromic Iridocyclitis. ( 26939115 )
2016
5
Risk Factors for Glaucoma in a Cohort of Patients with Fuchs Heterochromic Iridocyclitis. ( 27494676 )
2016
6
Acute granulomatous iridocyclitis in a child with tubulointerstitial nephritis and uveitis syndrome. ( 25861394 )
2015
7
Bilateral acute iris transillumination (BAIT) initially misdiagnosed as acute iridocyclitis. ( 25945534 )
2015
8
Polymorphisms in cytomegalovirus genotype in immunocompetent patients with corneal endotheliitis or iridocyclitis. ( 25963863 )
2015
9
Analysis on the psychological characteristics of patients with acute iridocyclitis. ( 26086022 )
2015
10
Syphilis iridocyclitis in a patient with type 1 diabetes. ( 27180731 )
2015
11
Fuch's Heterochromic Iridocyclitis in Iran: Is the Disease Going to Fade Away? ( 26730326 )
2015
12
Clinical, histopathological and immunohistochemical characterization of a novel equine ocular disorder: heterochromic iridocyclitis with secondary keratitis in adult horses. ( 25399915 )
2014
13
Small-incision cataract surgery in patients with Fuch's heterochromic iridocyclitis. ( 25680261 )
2014
14
Herniation of the retina in the central macula in an adult after iridocyclitis. ( 26011975 )
2014
15
Implantation of iris-claw Artisan intraocular lens for aphakia in Fuchs' heterochromic iridocyclitis. ( 23571252 )
2013
16
Surgical management of secondary glaucoma in Fuchs' heterochromic iridocyclitis. ( 23519886 )
2013
17
Associations of Fuchs heterochromic iridocyclitis in a South Indian patient population. ( 23514352 )
2013
18
Hypertensive iridocyclitis associated with delayed onset biopsy proven Cytomegalovirus retinitis. ( 23548320 )
2013
19
Polymorphisms of TNFAIP3 Gene in a Chinese Han Population with Fuchs Heterochromic Iridocyclitis. ( 23463983 )
2013
20
Chikungunya virus iridocyclitis in Fuchs' heterochromic iridocyclitis. ( 22218256 )
2012
21
Frequency of iridocyclitis in patients with early psoriatic arthritis: a prospective, follow up study. ( 22898222 )
2012
22
Fuchs' heterochromic iridocyclitis associated with ocular toxocariasis. ( 21331701 )
2011
23
Fuchs heterochromic iridocyclitis and the rubella virus. ( 21897135 )
2011
24
Corneal astigmatism in unilateral Fuchs heterochromic iridocyclitis. ( 21595529 )
2011
25
Adenoma of the nonpigmented ciliary epithelium presenting with recurrent iridocyclitis: unique expression of glial fibrillary acidic protein. ( 21088853 )
2011
26
Bilateral acute depigmentation of the iris first misdiagnosed as acute iridocyclitis. ( 21633847 )
2011
27
Rubella virus as a possible etiological agent of Fuchs heterochromic iridocyclitis. ( 20585798 )
2010
28
Expression Profile of Intravitreous Cytokines, Chemokines and Growth Factors in Patients with Fuchs Heterochromic Iridocyclitis. ( 20737053 )
2010
29
Confocal scan features of keratic precipitates in Fuchs heterochromic iridocyclitis. ( 19907293 )
2010
30
Chikungunya virus iridocyclitis in Fuchs' heterochromic iridocyclitis. ( 20952847 )
2010
31
Levocetirizine-induced iridocyclitis in a patient with allergic rhinitis. ( 20232781 )
2010
32
The possible role of systemic azithromycin for idiopathic iridocyclitis. ( 19891670 )
2010
33
Sarcoidosis presenting with massive splenomegaly in a child with a history of iridocyclitis and sensorineural deafness. ( 20615071 )
2010
34
Retinal thickening in iridocyclitis. ( 19477710 )
2009
35
Fuchs heterochromic iridocyclitis--syndrome, disease, or both? ( 19782794 )
2009
36
Klebsiella pneumoniae endophthalmitis secondary to liver abscess presenting as acute iridocyclitis. ( 19772282 )
2009
37
Presumed Fuchs heterochromic iridocyclitis and Posner-Schlossman syndrome: comparison of cytomegalovirus-positive and -negative eyes. ( 19463548 )
2009
38
Idiopathic no more: clues to the pathogenesis of Fuchs heterochromic iridocyclitis and glaucomatocyclitic crisis. ( 18435976 )
2008
39
Presumed fuchs heterochromic iridocyclitis and Posner-Schlossman syndrome: comparison of cytomegalovirus-positive and negative eyes. ( 19027423 )
2008
40
Epidemiologic relationship between fuchs heterochromic iridocyclitis and the United States rubella vaccination program. ( 17631266 )
2007
41
Kinetics of aqueous flare, intraocular pressure and virus-DNA copies in a patient with cytomegalovirus iridocyclitis without retinitis. ( 17522780 )
2007
42
Ophthalmomyiasis associated with Fuchs heterochromic iridocyclitis. ( 17031305 )
2006
43
Hypertensive iridocyclitis. ( 16782945 )
2006
44
Iridocyclitis associated with angle-supported phakic intraocular lenses. ( 16814060 )
2006
45
Rubella virus is associated with fuchs heterochromic iridocyclitis. ( 16387009 )
2006
46
When should intraocular lenses be implanted in patients with juvenile idiopathic arthritis-associated iridocyclitis? ( 17057416 )
2006
47
Outcomes of treatment with immunomodulatory therapy in patients with corticosteroid-resistant juvenile idiopathic arthritis-associated chronic iridocyclitis. ( 16419420 )
2005
48
Hereditary haemorrhagic telangiectasia associated with vitiligo, autoimmune thyroiditis, iridocyclitis and a myelodysplastic syndrome. ( 15953101 )
2005
49
Cat-scratch disease (ocular bartonellosis) presenting as bilateral recurrent iridocyclitis. ( 15714406 )
2005
50
Outcomes of phacoemulsification and in-the-bag intraocular lens implantation in Fuchs' heterochromic iridocyclitis. ( 15975468 )
2005

Variations for Iridocyclitis

Expression for Iridocyclitis

Search GEO for disease gene expression data for Iridocyclitis.

Pathways for Iridocyclitis

Pathways related to Iridocyclitis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 12.04 CD40LG TNFAIP3 TNFRSF10B
2
Show member pathways
11.95 HLA-B HLA-DPB1 TNFAIP3 TNFRSF10B
3 11.74 HLA-B HLA-DPB1 TNFAIP3
4 11.59 CD40LG TNFAIP3 TNFRSF10B
5 10.96 CD40LG HLA-B HLA-DPB1
6 10.8 CD40LG TNFAIP3

GO Terms for Iridocyclitis

Cellular components related to Iridocyclitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 ER to Golgi transport vesicle membrane GO:0012507 9.16 HLA-B HLA-DPB1
2 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.96 HLA-B HLA-DPB1
3 cell surface GO:0009986 8.92 CD40LG HLA-B HLA-DPB1 TNFRSF10B

Biological processes related to Iridocyclitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.54 CD40LG TNFAIP3 TNFRSF10B
2 interferon-gamma-mediated signaling pathway GO:0060333 9.32 HLA-B HLA-DPB1
3 positive regulation of T cell proliferation GO:0042102 9.26 CD40LG HLA-DPB1
4 antigen processing and presentation GO:0019882 9.16 HLA-B HLA-DPB1
5 immune response GO:0006955 9.02 CD40LG CYP11B1 HLA-B HLA-DPB1 TNFRSF10B
6 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 8.96 TNFAIP3 TNFRSF10B

Molecular functions related to Iridocyclitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 8.62 HLA-B HLA-DPB1

Sources for Iridocyclitis

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34 ICD10 via Orphanet
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