MCID: IRT001
MIFTS: 42

Iritis malady

Eye diseases category
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Summaries for Iritis

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Sources:
65Wikipedia, 33MalaCards
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Wikipedia:65 Uveitis is, broadly, inflammation of the uvea. The uvea consists of the middle, pigmented vascular... more...

MalaCards: Iritis is related to ankylosing spondylitis and syphilis. An important gene associated with Iritis is MRAP (melanocortin 2 receptor accessory protein), and among its related pathways are Development Angiotensin activation of ERK and B Cell Receptor Signaling Pathway. The drugs loteprednol etabonate and loteprednol and the compounds melphalan and carnitine have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and skin.

Aliases & Classifications for Iritis

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Sources:
8Disease Ontology, 10DISEASES, 62UMLS, 58SNOMED-CT, 40NCIt, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

iritis 8 10 62


External Ids:

Disease Ontology8 DOID:1406
NCIt40 C50621
SNOMED-CT58 65074000
MeSH35 D007500

Related Diseases for Iritis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Iritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 108)
idRelated DiseaseScoreTop Affiliating Genes
1ankylosing spondylitis30.6CD40LG, CD79A
2syphilis30.4CD79A
3inflammatory bowel disease29.9CD79A, MRAP
4nephritis29.8CD79A, CD40LG
5spondylitis10.4
6arthritis10.4
7herpes simplex10.3
8keratitis10.3
9cataract10.3
10hypopyon10.3
11glaucoma10.2
12uveitis10.2
13blindness10.2
14juvenile rheumatoid arthritis10.1
15herpes zoster10.1
16diabetic autonomic neuropathy10.1
17autonomic neuropathy10.1
18conjunctivitis10.1
19neuropathy10.1
20retinitis10.1
21rheumatoid arthritis10.1
22herpes zoster ophthalmicus10.1
23q fever10.1CD79A
24macroglobulinemia10.1CD79A
25cryptosporidiosis10.1CD79A
26ulcerative colitis10.1
27blau syndrome10.1
28hepatitis10.1
29iridocyclitis10.1
30leprosy10.1
31melanoma10.1
32meningitis10.1
33pneumonia10.1
34norrie disease10.1
35stromal keratitis10.1
36endotheliitis10.1
37primary hyperoxaluria10.0CD79A, EPO
38congenital toxoplasmosis10.0CD40LG, CD79A
39immunoglobulin g deficiency10.0CD40LG, CD79A
40selective iga deficiency disease10.0CD40LG, CD79A
41immunodeficiency, centromere instability and facial anomalies syndrome10.0CD40LG, CD79A
42immunoglobulin alpha deficiency10.0CD79A, CD40LG
43immunodeficiency with hyper igm type 110.0CD40LG, CD79A
44cryoglobulinemia10.0CD79A, CD40LG
45rubella10.0CD40LG, CD79A
46autoimmune hemolytic anemia10.0CD79A, CD40LG
47infectious mononucleosis10.0CD79A, CD40LG
48toxoplasmosis10.0CD40LG, CD79A
49agammaglobulinemia10.0CD79A, CD40LG
50immunodeficiency, common variable, 710.0CD79A, CD40LG

Graphical network of the top 20 diseases related to Iritis:



Diseases related to iritis

Symptoms for Iritis

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Drugs & Therapeutics for Iritis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Iritis

Search NIH Clinical Center for Iritis

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Iritis

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Anatomical Context for Iritis

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Sources:
33MalaCards
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MalaCards organs/tissues related to Iritis:

33
Eye, Testes, Skin, Retina, Endothelial

Animal Models for Iritis or affiliated genes

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Publications for Iritis

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Sources:
52PubMed
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Articles related to Iritis:

(show top 50)    (show all 220)
idTitleAuthorsYear
1
Intense pulsed light therapy (IPL) induced iritis following treatment for a medial canthal capillary malformation. (24417640)
2014
2
Bilateral acute pyogenic conjunctivitis with iritis induced by unilateral topical application of bacterial peptidoglycan muramyl dipeptide in adult rabbits. (24135297)
2013
3
Images in emergency medicine. Young boy with eye pain. Herpes zoster ophthalmicus, varicella zoster stromal keratitis, episcleritis and iritis. (23089088)
2012
4
Iritis and iris atrophy after eyebrow epilation with alexandrite laser. (22205833)
2011
5
Severe iritis and choroidal effusion following selective laser trabeculoplasty. (18831426)
2008
6
Bilateral ankle edema with bilateral iritis. (16633708)
2007
7
An outbreak of iritis and uveitis in dairy cattle at pasture associated with the supplementary feeding of baleage. (16751847)
2006
8
Clinically unsuspected diffuse uveal melanoma presenting as recurrent iritis. (15327114)
2004
9
Placement of a collagen glaucoma drainage device to control intraocular pressure and chronic iritis secondary to juvenile rheumatoid arthritis. (12027105)
2002
10
Blau syndrome (familial granulomatous arthritis, iritis, and rash) in an african-american family. (19078446)
2000
11
Iritis and hypotony after treatment with intravenous cidofovir for cytomegalovirus retinitis. (9194724)
1997
12
Ovine iritis. (8498008)
1993
13
Acute iritis and transient renal impairment following thrombolytic therapy for acute myocardial infarction. (8305792)
1993
14
Iritis and Wells' syndrome. (1459774)
1992
15
Iritis and papillitis as a primary presentation of Lyme disease. (2310116)
1990
16
Conjunctivitis versus iritis. (2400624)
1990
17
Bovine iritis. (2756627)
1989
18
Familial granulomatous arthritis, iritis, and rash. (4056967)
1985
19
Acute interstitial nephritis and iritis. Renal-ocular syndrome. (6741981)
1984
20
Migration of acetylated hemicellulose from capillary hemodialyzer to blood, causing scleritis and/or iritis. (6508598)
1984
21
Diagnostic ultrasound in cases of acute iritis. (306769)
1978
22
Adenine arabinoside therapy in corneal stromal disease and iritis due to herpes simplex. (4359979)
1974
23
Uncommon complications of early syphilis. Hepatitis, periostitis, iritis with papillitis, and meningitis. (5015962)
1972
24
The chemotherapy of herpes iritis with adenine arabinoside and cytarabine. (4992187)
1970
25
Uveitis (iritis) associated with ulcerative and granulomatous colitis. (6018375)
1967
26
HETEROCHROMIC IRITIS AND SECONDARY NEOVASCULAR GLAUCOMA. (14129264)
1964
27
Pathology of Herpes Simplex Kerato-Iritis. (16693633)
1963
28
Phenylbutazone in treatment of postoperative iritis. (13813750)
1960
29
Ankylosing spondylitis and rheumatic iritis. (14415719)
1959
30
Bechcet's syndrome, aphthosis; relapsing iritis with resulting blindness; recurrent genital and oral aphthae; migrating polyarthritis; erythema nodosum; involvement of the central nervous system; nonspecific reactivity of the skin. (12996081)
1952
31
Seasonal allergic iritis; case report. (12986591)
1952
32
Posterior exudative iritis. (12996625)
1952
33
Increased intraocular pressure associated with herpes zoster ophthalmicus without any signs of iritis. (14846578)
1951
34
Recurrent aphthous ulceration of oral mucous membrane and genitals associated with recurrent hypopyon iritis (Behcet's syndrome). (20994217)
1946
35
Bilateral iritis due to sarcoidosis. (21065045)
1946
36
The role of lens substance in experimental gonorrheal iritis. (21000616)
1946
37
Syphilitic iritis with particular reference to the Herxheimer reaction as a diagnostic aid and response to different treatment including penicillin. (21006582)
1945
38
Pathology of the Lens in Non-Traumatic Iritis. (16693319)
1943
39
IRITIS IN FOWLS. (18169673)
1940
40
IRITIS (WHITE EYE) IN FOWLS: With an account of the Histological Changes in the Eye. (18169656)
1939
41
The Character of Iritis Caused by Focal Infection. (16692569)
1921
42
DISCUSSION ON THE A8TIOLOGY AND TREATMENT OF IRITIS. (20904267)
1917
43
DISCUSSION ON THE AETIOLOGY AND TREATMENT OF IRITIS. (19979874)
1917
44
DISCUSSION ON THE AETIOLOGY AND TREATMENT OF IRITIS. (19979869)
1917
45
DISCUSSION ON THE AETIOLOGY AND TREATMENT OF IRITIS: OPENING ADDRESS BY THE PRESIDENT. (19979865)
1917
46
Iritis; Some Facts of General Interest. (18736121)
1913
47
Double Tubercular Iritis. (19977296)
1913
48
THE ETIOLOGY OF IRITIS. (20765559)
1911
49
Remarks on Gonorrhoeal Iritis. (20755882)
1895
50
Iridectomy in Chronic Iritis. (16691765)
1884

Variations for Iritis

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Expression for genes affiliated with Iritis

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Iritis

Search GEO for disease gene expression data for Iritis.

Pathways for genes affiliated with Iritis

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Sources:
50PathCards, 60Thomson Reuters, 38NCBI BioSystems Database, 30KEGG
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Pathways related to Iritis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Development EDNRB signaling60
Development ACM2 and ACM4 activation of ERK60
Cell adhesion Integrin inside out signaling60
Development G Proteins mediated regulation MARK ERK signaling60
Signal transduction IP3 signaling60
Development Angiotensin signaling via PYK260
Development EPO induced MAPK pathway60
9.3CD79A, EPO
2
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
9.0CD40LG, CD79A
39.0CD40LG, CD79A

Compounds for genes affiliated with Iritis

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Sources:
45Novoseek, 51PharmGKB, 11DrugBank, 3BitterDB, 29IUPHAR, 61Tocris Bioscience, 24HMDB
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Compounds related to Iritis according to GeneCards/GeneDecks:

(show top 50)    (show all 52)
idCompoundScoreTop Affiliating Genes
1melphalan45 51 1111.7CD79A, EPO
2carnitine459.6CD79A, EPO
3azathioprine45 3 51 1112.5CD79A, EPO
4sulfolipid i459.5CD40LG, CD79A
5sialic acid459.5EPO, CD79A
6sandoglobulin459.5CD40LG, CD79A
7gamma globulin459.5CD40LG, CD79A
8vancomycin45 1110.5CD79A, CD40LG
9pneumococcal459.5CD40LG, CD79A
10ribavirin45 51 1111.5EPO, CD40LG
11blys459.5CD40LG, CD79A
12tuberculin459.5CD79A, CD40LG
13praziquantel45 1110.5CD40LG, CD79A
14hemocyanin459.4CD40LG, CD79A
15inositol459.4CD79A, EPO
16gliadin459.4CD40LG, CD79A
17pmma459.4CD40LG, CD79A
18silicone459.4CD40LG, CD79A
19mannan459.4CD79A, CD40LG
20okt3459.4CD40LG, CD79A
21glutaraldehyde459.4CD40LG, CD79A
22sulfasalazine29 45 51 1112.4CD40LG, CD79A
23cardiolipin45 1110.4CD40LG, CD79A
24thalidomide45 51 61 1112.4EPO, CD40LG
25valproate459.4CD40LG, CD79A
26cytidine45 24 1111.4CD79A, CD40LG
27phenytoin45 51 29 1112.4CD79A, CD40LG
28anti-fungal459.4CD40LG, CD79A
29ivig459.4CD40LG, CD79A
30neopterin459.3CD40LG, CD79A
31allergens459.3CD79A, CD40LG
32rituximab45 51 1111.3CD40LG, CD79A
33polyethylene glycol459.3CD40LG, CD79A
34biotin45 24 1111.2CD40LG, CD79A
35thyroxine45 2410.1CD40LG, CD79A
36hyaluronic acid45 2410.0CD79A, CD40LG
37aspirin45 51 29 2412.0CD40LG, CD79A
38mycophenolate mofetil45 51 1111.0CD40LG, CD79A, EPO
39doxycycline45 1110.0EPO, CD79A, CD40LG
40vitamin b12459.0CD40LG, CD79A, EPO
41theophylline45 29 24 1111.9EPO, CD79A, CD40LG
42folate458.9CD40LG, CD79A, EPO
43formaldehyde45 249.9CD40LG, CD79A
44ascorbic acid45 249.9EPO, CD79A, CD40LG
45cyclosporin a45 29 6110.9EPO, CD79A, CD40LG
46lactate458.9EPO, CD79A, CD40LG
47creatinine458.9CD40LG, CD79A, EPO
48testosterone45 61 24 1111.8CD40LG, CD79A, EPO
49phosphatidylserine45 29 1110.7CD40LG, CD79A
50vegf458.7EPO, CD79A, CD40LG

GO Terms for genes affiliated with Iritis

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Sources:
16Gene Ontology
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Cellular components related to Iritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.0CD40LG, CD79A

Biological processes related to Iritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1B cell differentiationGO:0301839.0CD40LG, CD79A
2B cell proliferationGO:0421008.7CD40LG, CD79A

Products for genes affiliated with Iritis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Iritis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet