MCID: IRT001
MIFTS: 42

Iritis malady

Eye diseases category

Summaries for Iritis

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Sources:
66Wikipedia, 34MalaCards
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Wikipedia:66 Uveitis is, broadly, inflammation of the uvea. The uvea consists of the middle, pigmented vascular... more...

MalaCards: Iritis is related to ankylosing spondylitis and syphilis. An important gene associated with Iritis is MRAP (melanocortin 2 receptor accessory protein), and among its related pathways are Development Angiotensin activation of ERK and B Cell Receptor Signaling Pathway. The drugs loteprednol etabonate and loteprednol and the compounds melphalan and carnitine have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and skin.

Aliases & Classifications for Iritis

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Sources:
9Disease Ontology, 11DISEASES, 63UMLS, 59SNOMED-CT, 41NCIt, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

iritis 9 11 63


External Ids:

Disease Ontology9 DOID:1406
NCIt41 C50621
SNOMED-CT59 65074000
MeSH36 D007500

Related Diseases for Iritis

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Iritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 108)
idRelated DiseaseScoreTop Affiliating Genes
1ankylosing spondylitis30.6CD40LG, CD79A
2syphilis30.4CD79A
3inflammatory bowel disease29.9CD79A, MRAP
4nephritis29.8CD79A, CD40LG
5spondylitis10.4
6arthritis10.4
7herpes simplex10.3
8keratitis10.3
9cataract10.3
10hypopyon10.3
11glaucoma10.2
12uveitis10.2
13blindness10.2
14juvenile rheumatoid arthritis10.1
15herpes zoster10.1
16diabetic autonomic neuropathy10.1
17autonomic neuropathy10.1
18conjunctivitis10.1
19neuropathy10.1
20retinitis10.1
21rheumatoid arthritis10.1
22herpes zoster ophthalmicus10.1
23q fever10.1CD79A
24macroglobulinemia10.1CD79A
25cryptosporidiosis10.1CD79A
26ulcerative colitis10.1
27blau syndrome10.1
28hepatitis10.1
29iridocyclitis10.1
30leprosy10.1
31melanoma10.1
32meningitis10.1
33pneumonia10.1
34norrie disease10.1
35stromal keratitis10.1
36endotheliitis10.1
37primary hyperoxaluria10.0CD79A, EPO
38congenital toxoplasmosis10.0CD40LG, CD79A
39immunoglobulin g deficiency10.0CD40LG, CD79A
40selective iga deficiency disease10.0CD40LG, CD79A
41immunodeficiency, centromere instability and facial anomalies syndrome10.0CD40LG, CD79A
42immunoglobulin alpha deficiency10.0CD79A, CD40LG
43immunodeficiency with hyper igm type 110.0CD40LG, CD79A
44cryoglobulinemia10.0CD79A, CD40LG
45rubella10.0CD40LG, CD79A
46autoimmune hemolytic anemia10.0CD79A, CD40LG
47infectious mononucleosis10.0CD79A, CD40LG
48toxoplasmosis10.0CD40LG, CD79A
49agammaglobulinemia10.0CD79A, CD40LG
50immunodeficiency, common variable, 710.0CD79A, CD40LG

Graphical network of the top 20 diseases related to Iritis:



Diseases related to iritis

Symptoms for Iritis

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Drugs & Therapeutics for Iritis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Iritis

Drug clinical trials:

Search ClinicalTrials for Iritis

Search NIH Clinical Center for Iritis

Search CenterWatch for Iritis

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Iritis

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Anatomical Context for Iritis

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Sources:
34MalaCards
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MalaCards organs/tissues related to Iritis:

34
Eye, Testes, Skin, Retina, Endothelial

Animal Models for Iritis or affiliated genes

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Publications for Iritis

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Sources:
53PubMed
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Articles related to Iritis:

(show top 50)    (show all 220)
idTitleAuthorsYear
1
Intense pulsed light therapy (IPL) induced iritis following treatment for a medial canthal capillary malformation. (24417640)
2014
2
Bilateral acute pyogenic conjunctivitis with iritis induced by unilateral topical application of bacterial peptidoglycan muramyl dipeptide in adult rabbits. (24135297)
2013
3
Images in emergency medicine. Young boy with eye pain. Herpes zoster ophthalmicus, varicella zoster stromal keratitis, episcleritis and iritis. (23089088)
2012
4
Iritis and iris atrophy after eyebrow epilation with alexandrite laser. (22205833)
2011
5
Severe iritis and choroidal effusion following selective laser trabeculoplasty. (18831426)
2008
6
Bilateral ankle edema with bilateral iritis. (16633708)
2007
7
An outbreak of iritis and uveitis in dairy cattle at pasture associated with the supplementary feeding of baleage. (16751847)
2006
8
Clinically unsuspected diffuse uveal melanoma presenting as recurrent iritis. (15327114)
2004
9
Placement of a collagen glaucoma drainage device to control intraocular pressure and chronic iritis secondary to juvenile rheumatoid arthritis. (12027105)
2002
10
Blau syndrome (familial granulomatous arthritis, iritis, and rash) in an african-american family. (19078446)
2000
11
Iritis and hypotony after treatment with intravenous cidofovir for cytomegalovirus retinitis. (9194724)
1997
12
Ovine iritis. (8498008)
1993
13
Acute iritis and transient renal impairment following thrombolytic therapy for acute myocardial infarction. (8305792)
1993
14
Iritis and Wells' syndrome. (1459774)
1992
15
Iritis and papillitis as a primary presentation of Lyme disease. (2310116)
1990
16
Conjunctivitis versus iritis. (2400624)
1990
17
Bovine iritis. (2756627)
1989
18
Familial granulomatous arthritis, iritis, and rash. (4056967)
1985
19
Acute interstitial nephritis and iritis. Renal-ocular syndrome. (6741981)
1984
20
Migration of acetylated hemicellulose from capillary hemodialyzer to blood, causing scleritis and/or iritis. (6508598)
1984
21
Diagnostic ultrasound in cases of acute iritis. (306769)
1978
22
Adenine arabinoside therapy in corneal stromal disease and iritis due to herpes simplex. (4359979)
1974
23
Uncommon complications of early syphilis. Hepatitis, periostitis, iritis with papillitis, and meningitis. (5015962)
1972
24
The chemotherapy of herpes iritis with adenine arabinoside and cytarabine. (4992187)
1970
25
Uveitis (iritis) associated with ulcerative and granulomatous colitis. (6018375)
1967
26
HETEROCHROMIC IRITIS AND SECONDARY NEOVASCULAR GLAUCOMA. (14129264)
1964
27
Pathology of Herpes Simplex Kerato-Iritis. (16693633)
1963
28
Phenylbutazone in treatment of postoperative iritis. (13813750)
1960
29
Ankylosing spondylitis and rheumatic iritis. (14415719)
1959
30
Bechcet's syndrome, aphthosis; relapsing iritis with resulting blindness; recurrent genital and oral aphthae; migrating polyarthritis; erythema nodosum; involvement of the central nervous system; nonspecific reactivity of the skin. (12996081)
1952
31
Seasonal allergic iritis; case report. (12986591)
1952
32
Posterior exudative iritis. (12996625)
1952
33
Increased intraocular pressure associated with herpes zoster ophthalmicus without any signs of iritis. (14846578)
1951
34
Recurrent aphthous ulceration of oral mucous membrane and genitals associated with recurrent hypopyon iritis (Behcet's syndrome). (20994217)
1946
35
Bilateral iritis due to sarcoidosis. (21065045)
1946
36
The role of lens substance in experimental gonorrheal iritis. (21000616)
1946
37
Syphilitic iritis with particular reference to the Herxheimer reaction as a diagnostic aid and response to different treatment including penicillin. (21006582)
1945
38
Pathology of the Lens in Non-Traumatic Iritis. (16693319)
1943
39
IRITIS IN FOWLS. (18169673)
1940
40
IRITIS (WHITE EYE) IN FOWLS: With an account of the Histological Changes in the Eye. (18169656)
1939
41
The Character of Iritis Caused by Focal Infection. (16692569)
1921
42
DISCUSSION ON THE A8TIOLOGY AND TREATMENT OF IRITIS. (20904267)
1917
43
DISCUSSION ON THE AETIOLOGY AND TREATMENT OF IRITIS. (19979874)
1917
44
DISCUSSION ON THE AETIOLOGY AND TREATMENT OF IRITIS. (19979869)
1917
45
DISCUSSION ON THE AETIOLOGY AND TREATMENT OF IRITIS: OPENING ADDRESS BY THE PRESIDENT. (19979865)
1917
46
Iritis; Some Facts of General Interest. (18736121)
1913
47
Double Tubercular Iritis. (19977296)
1913
48
THE ETIOLOGY OF IRITIS. (20765559)
1911
49
Remarks on Gonorrhoeal Iritis. (20755882)
1895
50
Iridectomy in Chronic Iritis. (16691765)
1884

Variations for Iritis

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Expression for genes affiliated with Iritis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Iritis

Search GEO for disease gene expression data for Iritis.

Pathways for genes affiliated with Iritis

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Sources:
51PathCards, 61Thomson Reuters, 39NCBI BioSystems Database, 31KEGG
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Pathways related to Iritis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Development EDNRB signaling61
Development ACM2 and ACM4 activation of ERK61
Cell adhesion Integrin inside out signaling61
Development G Proteins mediated regulation MARK ERK signaling61
Signal transduction IP3 signaling61
Development Angiotensin signaling via PYK261
Development EPO induced MAPK pathway61
9.3CD79A, EPO
2
Show member pathways
BCR signaling pathway39
TCR Signaling Pathway39
9.0CD40LG, CD79A
39.0CD40LG, CD79A

Compounds for genes affiliated with Iritis

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Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 3BitterDB, 30IUPHAR, 62Tocris Bioscience, 25HMDB
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Compounds related to Iritis according to GeneCards/GeneDecks:

(show top 50)    (show all 52)
idCompoundScoreTop Affiliating Genes
1melphalan46 52 1211.7CD79A, EPO
2carnitine469.6CD79A, EPO
3azathioprine46 3 52 1212.5CD79A, EPO
4sulfolipid i469.5CD40LG, CD79A
5sialic acid469.5EPO, CD79A
6sandoglobulin469.5CD40LG, CD79A
7gamma globulin469.5CD40LG, CD79A
8vancomycin46 1210.5CD79A, CD40LG
9pneumococcal469.5CD40LG, CD79A
10ribavirin46 52 1211.5EPO, CD40LG
11blys469.5CD40LG, CD79A
12tuberculin469.5CD79A, CD40LG
13praziquantel46 1210.5CD40LG, CD79A
14hemocyanin469.4CD40LG, CD79A
15inositol469.4CD79A, EPO
16gliadin469.4CD40LG, CD79A
17pmma469.4CD40LG, CD79A
18silicone469.4CD40LG, CD79A
19mannan469.4CD79A, CD40LG
20okt3469.4CD40LG, CD79A
21glutaraldehyde469.4CD40LG, CD79A
22sulfasalazine30 46 52 1212.4CD40LG, CD79A
23cardiolipin46 1210.4CD40LG, CD79A
24thalidomide46 52 62 1212.4EPO, CD40LG
25valproate469.4CD40LG, CD79A
26cytidine46 25 1211.4CD79A, CD40LG
27phenytoin46 52 30 1212.4CD79A, CD40LG
28anti-fungal469.4CD40LG, CD79A
29ivig469.4CD40LG, CD79A
30neopterin469.3CD40LG, CD79A
31allergens469.3CD79A, CD40LG
32rituximab46 52 1211.3CD40LG, CD79A
33polyethylene glycol469.3CD40LG, CD79A
34biotin46 25 1211.2CD40LG, CD79A
35thyroxine46 2510.1CD40LG, CD79A
36hyaluronic acid46 2510.0CD79A, CD40LG
37aspirin46 52 30 2512.0CD40LG, CD79A
38mycophenolate mofetil46 52 1211.0CD40LG, CD79A, EPO
39doxycycline46 1210.0EPO, CD79A, CD40LG
40vitamin b12469.0CD40LG, CD79A, EPO
41theophylline46 30 25 1211.9EPO, CD79A, CD40LG
42folate468.9CD40LG, CD79A, EPO
43formaldehyde46 259.9CD40LG, CD79A
44ascorbic acid46 259.9EPO, CD79A, CD40LG
45cyclosporin a46 30 6210.9EPO, CD79A, CD40LG
46lactate468.9EPO, CD79A, CD40LG
47creatinine468.9CD40LG, CD79A, EPO
48testosterone46 62 25 1211.8CD40LG, CD79A, EPO
49phosphatidylserine46 30 1210.7CD40LG, CD79A
50vegf468.7EPO, CD79A, CD40LG

GO Terms for genes affiliated with Iritis

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Sources:
17Gene Ontology
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Cellular components related to Iritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.0CD40LG, CD79A

Biological processes related to Iritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1B cell differentiationGO:0301839.0CD40LG, CD79A
2B cell proliferationGO:0421008.7CD40LG, CD79A

Products for genes affiliated with Iritis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Iritis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet