MCID: IRT001
MIFTS: 41

Iritis malady

Summaries for Iritis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Uveitis is, broadly, inflammation of the uvea. The uvea consists of the middle, pigmented vascular... more...

MalaCards: Iritis is related to arthritis and ankylosing spondylitis. An important gene associated with Iritis is PRND (prion protein 2 (dublet)), and among its related pathways are Primary immunodeficiency and Immune response Fc epsilon RI pathway. The drugs tropicamide and loteprednol etabonate and the compounds okt3 and sulfolipid i have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and skin.

Aliases & Classifications for Iritis

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Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
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Aliases & Descriptions:

iritis 8 10 60


External Ids:

Disease Ontology8 DOID:1406
NCIt39 C50621
SNOMED-CT56 65074000
MeSH34 D007500

Related Diseases for Iritis

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Iritis:



Diseases related to iritis

Clinical Features for Iritis

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Drugs & Therapeutics for Iritis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Iritis

Drug clinical trials:

Search ClinicalTrials for Iritis

Search NIH Clinical Center for Iritis

Search CenterWatch for Iritis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Iritis

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Anatomical Context for Iritis

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Sources:
32MalaCards
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MalaCards organs/tissues related to Iritis:

32
Eye, Testes, Skin, Retina, Endothelial

Animal Models for Iritis or affiliated genes

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Publications for Iritis

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50PubMed
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Articles related to Iritis:

(show top 50)    (show all 223)
idTitleAuthorsYear
1
Images in emergency medicine. Young boy with eye pain. Herpes zoster ophthalmicus, varicella zoster stromal keratitis, episcleritis and iritis. (23089088)
2012
2
Cystoid macular edema after cataract surgery in a patient with previous severe iritis following argon laser peripheral iridoplasty. (21573094)
2011
3
An outbreak of iritis and uveitis in dairy cattle at pasture associated with the supplementary feeding of baleage. (16751847)
2006
4
Placement of a collagen glaucoma drainage device to control intraocular pressure and chronic iritis secondary to juvenile rheumatoid arthritis. (12027105)
2002
5
Blockage of complement regulators in the conjunctiva and within the eye leads to massive inflammation and iritis. (11899428)
2001
6
Iritis associated with Sweet's syndrome. (10971503)
2000
7
Prevention of herpes simplex keratitis and iritis. (9488290)
1998
8
Acute iritis induced by granulocyte colony-stimulating factor used for mobilization in a volunteer unrelated peripheral blood progenitor cell donor. (8704701)
1996
9
Metipranolol-associated granulomatous iritis. (7977597)
1994
10
Iritis after treatment with streptokinase. (8038677)
1994
11
Ovine iritis. (8498008)
1993
12
An unusual manifestation of Chlamydia pneumoniae infection: meningitis, hepatitis, iritis and atypical erythema nodosum. (8511521)
1993
13
Iritis and Wells' syndrome. (1459774)
1992
14
Bovine iritis. (2750040)
1989
15
Migration of acetylated hemicellulose from capillary hemodialyzer to blood, causing scleritis and/or iritis. (6508598)
1984
16
Diabetic autonomic neuropathy and iritis: an association suggesting an immunological cause. (6434071)
1984
17
Iritis in leprosy. (6963821)
1981
18
Effect of 9-(2-hydroxyethoxymethyl)guanine on herpesvirus-induced keratitis and iritis in rabbits. (217301)
1978
19
Iritis in patients with cutaneous melanoma and vitiligo. (718499)
1978
20
Letter: Double-blind trial for treatment of herpes iritis and stromal disease. (4357258)
1973
21
Varicella iritis. (5487234)
1970
22
Dendritic (herpetic) keratitis. II. Follow-up examination of corneal opacity. (Opacity, vascularisation, Hudson-StAohli's line, sequelae of iritis). (4912830)
1970
23
Uveitis (iritis) associated with ulcerative and granulomatous colitis. (6018375)
1967
24
PATHOLOGY OF HERPES SIMPLEX KERATO-IRITIS. (14141470)
1964
25
The management of iritis from the standpoint of the general practitioner. (13243972)
1955
26
Bechcet's syndrome, aphthosis; relapsing iritis with resulting blindness; recurrent genital and oral aphthae; migrating polyarthritis; erythema nodosum; involvement of the central nervous system; nonspecific reactivity of the skin. (12996081)
1952
27
Cortisone in iritis. (14897439)
1951
28
Acute iritis. (20253753)
1947
29
Cataract, recurrent iritis, and deafness secondary to injury by lightning. (21065240)
1946
30
Allergic iritis. (21022531)
1946
31
Syphilitic iritis with particular reference to the Herxheimer reaction as a diagnostic aid and response to different treatment including penicillin. (21006582)
1945
32
Iritis in a Dog. (17647744)
1941
33
ADRENALINE IN GLAUCOMA AND IRITIS. (18168686)
1927
34
TUBERCULIN IN TUBERCULOUS IRITIS. (18739023)
1923
35
THE RADICAL CURE OF GONORRHOEAL IRITIS. (18167973)
1920
36
DISCUSSION ON THE A8TIOLOGY AND TREATMENT OF IRITIS. (20904269)
1917
37
DISCUSSION ON THE A8TIOLOGY AND TREATMENT OF IRITIS. (20904268)
1917
38
DISCUSSION ON THE A8TIOLOGY AND TREATMENT OF IRITIS. (20904271)
1917
39
DISCUSSION ON THE A8TIOLOGY AND TREATMENT OF IRITIS: OPENING ADDRESS BY THE PRESIDENT. (20904262)
1917
40
DISCUSSION ON THE A8TIOLOGY AND TREATMENT OF IRITIS. (20904270)
1917
41
Iritis-Rheumatic and Toxaemic. (19978221)
1914
42
Iritis; Some Facts of General Interest. (18736121)
1913
43
Double Tubercular Iritis. (19977296)
1913
44
Complete Detachment of the Retina followed by Iritis: Spontaneous Replacement Three Months later. (19977264)
1913
45
THE ETIOLOGY OF IRITIS. (20765559)
1911
46
THE ETIOLOGY OF IRITIS. (20765622)
1911
47
Septicemia with Acute Fibrino-Purulent Pericarditis and Hypopyon Iritis caused by the Meningococcus. (19971859)
1908
48
Recurrent iritis, a study of nine cases. (16692051)
1905
49
CASE of RHEUMATIC FEVER COMPLICATED by CHOREA, IRITIS, and ENDOCARDITIS: RECOVERY. (20760748)
1903
50
On Iritis in Infancy. (20793706)
1845

Genetic Variations for Iritis

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Expression for genes affiliated with Iritis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Iritis

Search GEO for disease gene expression data for Iritis.

Pathways for genes affiliated with Iritis

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29KEGG, 12EMD Millipore
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Compounds for genes affiliated with Iritis

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Iritis according to GeneCards/GeneDecks:

(show all 36)
idCompoundScoreTop Affiliating Genes
1okt34410.2CD40LG
2sulfolipid i449.7CD79A, CD40LG
3sandoglobulin449.7CD79A, CD40LG
4vancomycin44 1110.7CD79A, CD40LG
5blys449.7CD79A, CD40LG
6tuberculin449.7CD40LG, CD79A
7praziquantel44 1110.7CD40LG, CD79A
8hemocyanin449.7CD79A, CD40LG
9gliadin449.6CD79A, CD40LG
10pmma449.6CD79A, CD40LG
11silicone449.6CD40LG, CD79A
12mannan449.6CD79A, CD40LG
13ursodeoxycholic acid44 11 2411.5HLA-B, CD40LG
14glutaraldehyde449.5CD79A, CD40LG
15sulfasalazine44 28 49 1112.5CD40LG, CD79A
16valproate449.4CD79A, CD40LG
17cytidine44 11 2411.3CD40LG, CD79A
18anti-fungal449.3CD79A, CD40LG
19pneumococcal449.2CD79A, CD40LG, HLA-B
20phenytoin44 49 28 1112.2HLA-B, CD40LG, CD79A
21polysaccharide449.0CD79A, CD40LG, HLA-B
22cimetidine44 28 1111.0HLA-B, EPO
23ribavirin44 49 1111.0EPO, CD40LG, HLA-B
24fibrinogen449.0CD79A, CD40LG, HLA-B
25mycophenolate mofetil44 49 1110.9CD40LG, CD79A, EPO
26doxycycline44 119.9CD40LG, CD79A, EPO
27vitamin b12448.9EPO, CD79A, CD40LG
28theophylline44 28 11 2411.9CD40LG, CD79A, EPO
29folate448.8EPO, CD79A, CD40LG
30pge2448.8HLA-B, CD40LG, CD79A, PLA2G2D
31ascorbic acid44 249.8EPO, CD79A, CD40LG
32paraffin448.5CD79A, CD40LG, HLA-B
33cyclosporin a44 28 5910.4EPO, CD79A, CD40LG, HLA-B
34lactate448.4HLA-B, CD40LG, CD79A, EPO
35creatinine448.3HLA-B, CD40LG, CD79A, EPO
36testosterone44 59 11 2411.3HLA-B, CD40LG, CD79A, EPO

GO Terms for genes affiliated with Iritis

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16Gene Ontology
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Cellular components related to Iritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058867.6SRP72, CD79A, CD40LG, PRND, HLA-B, MRAP

Biological processes related to Iritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1B cell differentiationGO:0301839.3CD79A, CD40LG
2B cell proliferationGO:0421009.0CD79A, CD40LG

Products for genes affiliated with Iritis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Iritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet