MCID: IRT001
MIFTS: 43

Iritis malady

Eye diseases category
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Summaries for Iritis

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Wikipedia:65 Uveitis is, broadly, inflammation of the uvea. The uvea consists of the middle, pigmented vascular... more...

MalaCards based summary: Iritis is related to syphilis and ankylosing spondylitis. An important gene associated with Iritis is MRAP (melanocortin 2 receptor accessory protein), and among its related pathways are Development Angiotensin activation of ERK and B Cell Receptor Signaling Pathway. The drugs loteprednol etabonate and loteprednol and the compounds melphalan and carnitine have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and skin.

Aliases & Classifications for Iritis

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Iritis, Aliases & Descriptions:

Name: Iritis 8 10 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


External Ids:

Disease Ontology8 DOID:1406
MeSH34 D007500
SNOMED-CT57 65074000
NCIt39 C50621

Related Diseases for Iritis

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Diseases related to Iritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 108)
idRelated DiseaseScoreTop Affiliating Genes
1syphilis30.9CD79A
2ankylosing spondylitis30.5CD40LG, CD79A
3inflammatory bowel disease30.0CD79A, MRAP
4nephritis29.8CD79A, CD40LG
5arthritis10.4
6spondylitis10.4
7q fever10.4CD79A
8keratitis10.4
9macroglobulinemia10.4CD79A
10cryptosporidiosis10.4CD79A
11herpes simplex10.3
12cataract10.3
13hypopyon10.3
14uveitis10.2
15blindness10.2
16rheumatoid arthritis10.2
17juvenile rheumatoid arthritis10.2
18herpes zoster10.2
19diabetic autonomic neuropathy10.2
20autonomic neuropathy10.2
21colitis10.2
22conjunctivitis10.2
23neuropathy10.2
24retinitis10.2
25herpes zoster ophthalmicus10.2
26hepatitis10.1
27ulcerative colitis10.1
28blau syndrome10.1
29iridocyclitis10.1
30leprosy10.1
31melanoma10.1
32meningitis10.1
33myopia10.1
34pneumonia10.1
35norrie disease10.1
36stromal keratitis10.1
37endotheliitis10.1
38primary hyperoxaluria10.1CD79A, EPO
39congenital toxoplasmosis10.0CD40LG, CD79A
40immunoglobulin g deficiency10.0CD40LG, CD79A
41selective iga deficiency disease10.0CD40LG, CD79A
42immunodeficiency, centromere instability and facial anomalies syndrome10.0CD40LG, CD79A
43immunoglobulin alpha deficiency10.0CD79A, CD40LG
44immunodeficiency with hyper igm type 110.0CD40LG, CD79A
45cryoglobulinemia10.0CD79A, CD40LG
46bruton-type agammaglobulinemia10.0CD79A, CD40LG
47rubella10.0CD40LG, CD79A
48autoimmune hemolytic anemia10.0CD79A, CD40LG
49infectious mononucleosis10.0CD79A, CD40LG
50toxoplasmosis10.0CD40LG, CD79A

Graphical network of the top 20 diseases related to Iritis:



Diseases related to iritis

Symptoms for Iritis

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Drugs & Therapeutics for Iritis

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Drug clinical trials:

Search ClinicalTrials for Iritis

Search NIH Clinical Center for Iritis

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Iritis

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Anatomical Context for Iritis

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MalaCards organs/tissues related to Iritis:

32
Eye, Testes, Skin, Retina, Endothelial

Animal Models for Iritis or affiliated genes

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Publications for Iritis

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Articles related to Iritis:

(show top 50)    (show all 222)
idTitleAuthorsYear
1
Intense pulsed light therapy (IPL) induced iritis following treatment for a medial canthal capillary malformation. (24417640)
2014
2
Bilateral acute pyogenic conjunctivitis with iritis induced by unilateral topical application of bacterial peptidoglycan muramyl dipeptide in adult rabbits. (24135297)
2013
3
Images in emergency medicine. Young boy with eye pain. Herpes zoster ophthalmicus, varicella zoster stromal keratitis, episcleritis and iritis. (23089088)
2012
4
Iritis and iris atrophy after eyebrow epilation with alexandrite laser. (22205833)
2011
5
Severe iritis and choroidal effusion following selective laser trabeculoplasty. (18831426)
2008
6
Latanoprost induced iritis after vitrectomy surgery. (25390234)
2007
7
Bilateral ankle edema with bilateral iritis. (16633708)
2007
8
An outbreak of iritis and uveitis in dairy cattle at pasture associated with the supplementary feeding of baleage. (16751847)
2006
9
Clinically unsuspected diffuse uveal melanoma presenting as recurrent iritis. (15327114)
2004
10
Placement of a collagen glaucoma drainage device to control intraocular pressure and chronic iritis secondary to juvenile rheumatoid arthritis. (12027105)
2002
11
Blau syndrome (familial granulomatous arthritis, iritis, and rash) in an african-american family. (19078446)
2000
12
Iritis and hypotony after treatment with intravenous cidofovir for cytomegalovirus retinitis. (9194724)
1997
13
Ovine iritis. (8498008)
1993
14
Acute iritis and transient renal impairment following thrombolytic therapy for acute myocardial infarction. (8305792)
1993
15
Iritis and Wells' syndrome. (1459774)
1992
16
Iritis and papillitis as a primary presentation of Lyme disease. (2310116)
1990
17
Conjunctivitis versus iritis. (2400624)
1990
18
Bovine iritis. (2756627)
1989
19
Familial granulomatous arthritis, iritis, and rash. (4056967)
1985
20
Acute interstitial nephritis and iritis. Renal-ocular syndrome. (6741981)
1984
21
Migration of acetylated hemicellulose from capillary hemodialyzer to blood, causing scleritis and/or iritis. (6508598)
1984
22
Diagnostic ultrasound in cases of acute iritis. (306769)
1978
23
Adenine arabinoside therapy in corneal stromal disease and iritis due to herpes simplex. (4359979)
1974
24
Uncommon complications of early syphilis. Hepatitis, periostitis, iritis with papillitis, and meningitis. (5015962)
1972
25
The chemotherapy of herpes iritis with adenine arabinoside and cytarabine. (4992187)
1970
26
Uveitis (iritis) associated with ulcerative and granulomatous colitis. (6018375)
1967
27
HETEROCHROMIC IRITIS AND SECONDARY NEOVASCULAR GLAUCOMA. (14129264)
1964
28
Phenylbutazone in treatment of postoperative iritis. (13813750)
1960
29
Ankylosing spondylitis and rheumatic iritis. (14415719)
1959
30
Bechcet's syndrome, aphthosis; relapsing iritis with resulting blindness; recurrent genital and oral aphthae; migrating polyarthritis; erythema nodosum; involvement of the central nervous system; nonspecific reactivity of the skin. (12996081)
1952
31
Seasonal allergic iritis; case report. (12986591)
1952
32
Posterior exudative iritis. (12996625)
1952
33
Increased intraocular pressure associated with herpes zoster ophthalmicus without any signs of iritis. (14846578)
1951
34
Recurrent aphthous ulceration of oral mucous membrane and genitals associated with recurrent hypopyon iritis (Behcet's syndrome). (20994217)
1946
35
Bilateral iritis due to sarcoidosis. (21065045)
1946
36
The role of lens substance in experimental gonorrheal iritis. (21000616)
1946
37
Syphilitic iritis with particular reference to the Herxheimer reaction as a diagnostic aid and response to different treatment including penicillin. (21006582)
1945
38
Pathology of the Lens in Non-Traumatic Iritis. (16693319)
1943
39
IRITIS IN FOWLS. (18169673)
1940
40
IRITIS (WHITE EYE) IN FOWLS: With an account of the Histological Changes in the Eye. (18169656)
1939
41
The Character of Iritis Caused by Focal Infection. (16692569)
1921
42
DISCUSSION ON THE A8TIOLOGY AND TREATMENT OF IRITIS. (20904267)
1917
43
DISCUSSION ON THE AETIOLOGY AND TREATMENT OF IRITIS. (19979874)
1917
44
DISCUSSION ON THE AETIOLOGY AND TREATMENT OF IRITIS. (19979869)
1917
45
DISCUSSION ON THE AETIOLOGY AND TREATMENT OF IRITIS: OPENING ADDRESS BY THE PRESIDENT. (19979865)
1917
46
Iritis; Some Facts of General Interest. (18736121)
1913
47
Double Tubercular Iritis. (19977296)
1913
48
THE ETIOLOGY OF IRITIS. (20765559)
1911
49
Remarks on Gonorrhoeal Iritis. (20755882)
1895
50
Iridectomy in Chronic Iritis. (16691765)
1884

Variations for Iritis

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Expression for genes affiliated with Iritis

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Expression patterns in normal tissues for genes affiliated with Iritis

Search GEO for disease gene expression data for Iritis.

Pathways for genes affiliated with Iritis

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Pathways related to Iritis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Development EDNRB signaling60
Development ACM2 and ACM4 activation of ERK60
Cell adhesion Integrin inside out signaling60
Development G Proteins mediated regulation MARK ERK signaling60
Signal transduction IP3 signaling60
Development Angiotensin signaling via PYK260
Development EPO induced MAPK pathway60
9.3CD79A, EPO
2
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
9.0CD40LG, CD79A
39.0CD40LG, CD79A

Compounds for genes affiliated with Iritis

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Compounds related to Iritis according to GeneCards/GeneDecks:

(show top 50)    (show all 52)
idCompoundScoreTop Affiliating Genes
1melphalan44 50 1111.7CD79A, EPO
2carnitine449.6CD79A, EPO
3azathioprine44 2 50 1112.5CD79A, EPO
4sulfolipid i449.5CD40LG, CD79A
5sialic acid449.5EPO, CD79A
6sandoglobulin449.5CD40LG, CD79A
7gamma globulin449.5CD40LG, CD79A
8vancomycin44 1110.5CD79A, CD40LG
9pneumococcal449.5CD40LG, CD79A
10ribavirin44 50 1111.5EPO, CD40LG
11blys449.5CD40LG, CD79A
12tuberculin449.5CD79A, CD40LG
13praziquantel44 1110.5CD40LG, CD79A
14hemocyanin449.4CD40LG, CD79A
15inositol449.4CD79A, EPO
16gliadin449.4CD40LG, CD79A
17pmma449.4CD40LG, CD79A
18silicone449.4CD40LG, CD79A
19mannan449.4CD79A, CD40LG
20okt3449.4CD40LG, CD79A
21glutaraldehyde449.4CD40LG, CD79A
22sulfasalazine28 44 50 1112.4CD40LG, CD79A
23cardiolipin44 1110.4CD40LG, CD79A
24thalidomide44 50 61 1112.4EPO, CD40LG
25valproate449.4CD40LG, CD79A
26cytidine44 24 1111.4CD79A, CD40LG
27phenytoin44 50 28 1112.4CD79A, CD40LG
28anti-fungal449.4CD40LG, CD79A
29ivig449.4CD40LG, CD79A
30neopterin449.3CD40LG, CD79A
31allergens449.3CD79A, CD40LG
32rituximab44 50 1111.3CD40LG, CD79A
33polyethylene glycol449.3CD40LG, CD79A
34biotin44 24 1111.2CD40LG, CD79A
35thyroxine44 2410.1CD40LG, CD79A
36hyaluronic acid44 2410.0CD79A, CD40LG
37aspirin44 50 28 2412.0CD40LG, CD79A
38mycophenolate mofetil44 50 1111.0CD40LG, CD79A, EPO
39doxycycline44 1110.0EPO, CD79A, CD40LG
40vitamin b12449.0CD40LG, CD79A, EPO
41theophylline44 28 24 1111.9EPO, CD79A, CD40LG
42folate448.9CD40LG, CD79A, EPO
43formaldehyde44 249.9CD40LG, CD79A
44ascorbic acid44 249.9EPO, CD79A, CD40LG
45cyclosporin a44 28 6110.9EPO, CD79A, CD40LG
46lactate448.9EPO, CD79A, CD40LG
47creatinine448.9CD40LG, CD79A, EPO
48testosterone44 61 24 1111.8CD40LG, CD79A, EPO
49phosphatidylserine44 28 1110.7CD40LG, CD79A
50vegf448.7EPO, CD79A, CD40LG

GO Terms for genes affiliated with Iritis

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Cellular components related to Iritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.0CD40LG, CD79A

Biological processes related to Iritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1B cell differentiationGO:0301839.0CD40LG, CD79A
2B cell proliferationGO:0421008.7CD40LG, CD79A

Products for genes affiliated with Iritis

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  • Antibodies
  • Proteins
  • Lysates

Sources for Iritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet