Aliases & Classifications for Iritis

MalaCards integrated aliases for Iritis:

Name: Iritis 12 72 41 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:1406
MeSH 41 D007500
NCIt 46 C50621
SNOMED-CT 64 65074000
UMLS 69 C0022081

Summaries for Iritis

MalaCards based summary : Iritis is related to hypopyon and pustulosis of palm and sole. An important gene associated with Iritis is HLA-B (Major Histocompatibility Complex, Class I, B), and among its related pathways/superpathways are Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway and Inflammatory Response Pathway. The drugs Acyclovir and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and testes, and related phenotype is Increased shRNA abundance.

Wikipedia : 72 Uveitis is the inflammation of the uvea, the pigmented layer that lies between the inner retina and the... more...

Related Diseases for Iritis

Diseases related to Iritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 133)
# Related Disease Score Top Affiliating Genes
1 hypopyon 30.4 HLA-B MRAP
2 pustulosis of palm and sole 29.6 MRAP TNFRSF1B
3 spondylitis 29.6 CD40LG HLA-B TNFRSF1B
4 iridocyclitis 29.3 CD40LG HLA-B MRAP
5 spondyloarthropathy 1 29.1 CD40LG HLA-B MRAP TNFRSF1B
6 bone inflammation disease 28.1 CD40LG MRAP PHB2 TNFRSF1B
7 endotheliitis 11.3
8 norrie disease 11.1
9 severe cutaneous adverse reaction 11.0
10 glaucomatocyclitic crisis 10.4 HLA-B MRAP
11 toxic optic neuropathy 10.3 EPO MRAP
12 pure red-cell aplasia 10.3 EPO HLA-B
13 balanitis 10.2 MRAP PHB2
14 spondyloarthropathy 10.2 HLA-B MRAP
15 enthesopathy 10.2 MRAP PHB2
16 penile disease 10.2 MRAP PHB2
17 bursitis 10.2 MRAP PHB2
18 tendinitis 10.2 MRAP PHB2
19 scleral disease 10.1 MRAP TNFRSF1B
20 tenosynovitis 10.1 MRAP TNFRSF1B
21 inflammatory spondylopathy 10.1
22 orbital plasma cell granuloma 10.1 MRAP TNFRSF1B
23 arthritis 10.1
24 anterior scleritis 10.1 MRAP TNFRSF1B
25 chronic orbital inflammation 10.1 MRAP TNFRSF1B
26 keratitis, hereditary 10.1
27 palindromic rheumatism 10.1 MRAP TNFRSF1B
28 herpes simplex 10.0
29 optic papillitis 10.0 CD40LG MRAP
30 aplastic anemia 10.0 EPO HLA-B SRP72
31 acute retinal necrosis syndrome 10.0 CD40LG MRAP
32 splenic disease 10.0 CD40LG EPO
33 indeterminate leprosy 10.0 CD40LG HLA-B
34 chorioretinitis 10.0 CD40LG MRAP
35 cervix disease 10.0 CD40LG MRAP
36 vulvitis 10.0 CD40LG MRAP
37 cataract 10.0
38 coccidiosis 9.9 CD40LG MRAP
39 byssinosis 9.9 CD40LG MRAP
40 intestinal disease 9.9 MRAP TNFRSF1B
41 echinococcosis 9.9 CD40LG HLA-B
42 uveitis 9.9
43 syphilis 9.9
44 rubella 9.9 CD40LG HLA-B
45 sclerosing cholangitis 9.9 CD40LG HLA-B
46 takayasu arteritis 9.8 CD40LG HLA-B
47 sickle cell anemia 9.8 CD40LG EPO
48 rheumatoid arthritis 9.8
49 colitis 9.8
50 diabetic autonomic neuropathy 9.8

Graphical network of the top 20 diseases related to Iritis:



Diseases related to Iritis

Symptoms & Phenotypes for Iritis

GenomeRNAi Phenotypes related to Iritis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance GR00327-A 8.8 CNOT1 EPO HLA-B

Drugs & Therapeutics for Iritis

Drugs for Iritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 60)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Acyclovir Phase 4
2 Anti-Infective Agents Phase 4
3 Antiviral Agents Phase 4
4 valacyclovir Phase 4
5
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
6
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
7
Difluprednate Approved Phase 2 23674-86-4 443936
8
Daclizumab Approved, Investigational Phase 2 152923-56-3
9
Triamcinolone Approved, Vet_approved Phase 2 124-94-7 31307
10
Ranibizumab Approved Phase 2 347396-82-1 459903
11
Bromfenac Approved July 1997 Phase 2 91714-94-2 60726
12 Antiemetics Phase 2
13 Anti-Inflammatory Agents Phase 2
14 Antineoplastic Agents, Hormonal Phase 2
15 Autonomic Agents Phase 2
16 Gastrointestinal Agents Phase 2
17 glucocorticoids Phase 2
18 Hormone Antagonists Phase 2
19 Hormones Phase 2
20 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
21 Methylprednisolone acetate Phase 2
22 Methylprednisolone Hemisuccinate Phase 2
23 Neuroprotective Agents Phase 2
24 Peripheral Nervous System Agents Phase 2
25 Prednisolone acetate Phase 2
26 Prednisolone hemisuccinate Phase 2
27 Prednisolone phosphate Phase 2
28 Protective Agents Phase 2
29 Fluprednisolone Phase 2
30 Antibodies Phase 2
31 Immunoglobulins Phase 2
32 Immunosuppressive Agents Phase 2
33 triamcinolone acetonide Phase 2
34 Triamcinolone diacetate Phase 2
35 Triamcinolone hexacetonide Phase 2
36 Analgesics Phase 2
37 Analgesics, Non-Narcotic Phase 2
38 Angiogenesis Inhibitors Phase 2
39 Angiogenesis Modulating Agents Phase 2
40 Anti-Inflammatory Agents, Non-Steroidal Phase 2
41 Antirheumatic Agents Phase 2
42 Ophthalmic Solutions Phase 2
43
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 5743
44
Diclofenac Approved, Vet_approved 15307-86-5 3033
45
Ephedrine Approved 299-42-3 9294
46
Pseudoephedrine Approved 90-82-4 7028
47
Lactitol Investigational 585-86-4 3871
48 BB 1101
49 Cathartics
50 Cyclooxygenase Inhibitors

Interventional clinical trials:

(show all 12)

# Name Status NCT ID Phase Drugs
1 Aurolab Hydrophobic Foldable Intraocular Lens Study Completed NCT00449267 Phase 4
2 Zoster Eye Disease Study Recruiting NCT03134196 Phase 4 Masked Placebo;Masked Oral Valacyclovir
3 Use of Topical Euphrasia, a Homeopathic Remedy in Ophthalmology Unknown status NCT02416128 Phase 2 Euphrasia;Prednisolone acetate
4 Study of Difluprednate Ophthalmic Emulsion in the Treatment of Uveitis Completed NCT00405496 Phase 2 Difluprednate Ophthalmic Emulsion
5 Human Anti-Tac (Daclizumab) to Treat Juvenile Idiopathic Arthritis (JIA)-Associated Uveitis Completed NCT00130637 Phase 2 Daclizumab
6 Combination Ranibizumab and Bromfenac for Neovascular Age-related Macular Degeneration Completed NCT00805233 Phase 2 combination ranibizumab + bromfenac;ranibizumab injection alone
7 The Safety and Efficacy of Chicken Type II Collagen on Uveitis Associated With Juvenile Rheumatoid Arthritis Completed NCT00001614 Phase 1 Chicken type II collagen
8 PEMF: an Adjunct Therapy for Anterior Uveitis Completed NCT01154010
9 Evaluation and Treatment of Patients With Inflammatory Eye Diseases Completed NCT00006188
10 Retinal OCT and (mfERG) Related to Age, Sex, and the Use of Anti-inflammatory Medications Completed NCT00476593 Diclofenac;Dexamethasone
11 Screening for NEI Clinical Studies Completed NCT00001734
12 To Evaluate Eye Installation-Tear Free Completed NCT02802917 SPF 50 Y49 091 (BAY 987516);SPF 50 X15 158 (BAY 987516);SPF 50 X15 160 (BAY 987516);SPF 50 X57 162 (BAY 987516)

Search NIH Clinical Center for Iritis

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: iritis

Genetic Tests for Iritis

Anatomical Context for Iritis

MalaCards organs/tissues related to Iritis:

38
Eye, Retina, Testes, Endothelial, Skin

Publications for Iritis

Articles related to Iritis:

(show top 50) (show all 231)
# Title Authors Year
1
Iritis ( 28613659 )
2017
2
Intravitreal aflibercept after bilateral bevacizumab-induced iritis. ( 25871873 )
2015
3
Free-Floating Iris Cyst in a Patient with Recurrent Iritis. ( 26120316 )
2015
4
Bilateral Iritis after Vaccine for Bladder Cancer. ( 26258277 )
2015
5
Chronic iritis associated with cutaneous leukocytoclastic vasculitis. ( 25939124 )
2015
6
Iritis, glaucoma and corneal decompensation associated with BrightOcular cosmetic iris implant. ( 26719491 )
2015
7
Corneal Endothelial Cell Loss and Iritis Associated With a New Cosmetic Iris Implant. ( 25811391 )
2015
8
Intense pulsed light therapy (IPL) induced iritis following treatment for a medial canthal capillary malformation. ( 24417640 )
2014
9
Visante OCT in the diagnosis of caterpillar-induced iritis. ( 23931492 )
2013
10
Bilateral acute pyogenic conjunctivitis with iritis induced by unilateral topical application of bacterial peptidoglycan muramyl dipeptide in adult rabbits. ( 24135297 )
2013
11
Images in emergency medicine. Young boy with eye pain. Herpes zoster ophthalmicus, varicella zoster stromal keratitis, episcleritis and iritis. ( 23089088 )
2012
12
Lay Person Slit Lamp Detection of Iritis in Absence of an Eye MD: Test of a Portable Model of Cells and Flare. ( 22747766 )
2012
13
Restrictive (Mechanical) Strabismus: An Epidemic? DNA or Not, Twins Faces, Texas, DRS, Iritis Monitoring. ( 22747761 )
2012
14
Iritis and iris atrophy after eyebrow epilation with alexandrite laser. ( 22205833 )
2011
15
Iritis and pupillary distortion after periorbital cosmetic alexandrite laser. ( 21057804 )
2011
16
Cystoid macular edema after cataract surgery in a patient with previous severe iritis following argon laser peripheral iridoplasty. ( 21573094 )
2011
17
Iritis, ptosis, and sequential severe loss of vision in a patient with essential thrombocytosis. ( 19696799 )
2010
18
Novel molecular imaging approach for subclinical detection of iritis and evaluation of therapeutic success. ( 20581051 )
2010
19
Iritis and iris neoplasm as the presenting signs of esophageal squamous cell carcinoma. ( 19606176 )
2009
20
Severe iritis and choroidal effusion following selective laser trabeculoplasty. ( 18831426 )
2008
21
Herpetic keratitis with iritis after corneal crosslinking with riboflavin and ultraviolet A for keratoconus. ( 17964410 )
2007
22
Hypopyon iritis after primary fresh amniotic membrane transplantation. ( 18043192 )
2007
23
Bilateral ankle edema with bilateral iritis. ( 16633708 )
2007
24
Latanoprost induced iritis after vitrectomy surgery. ( 25390234 )
2007
25
Intravitreal ganciclovir injections in aqueous cytomegalovirus DNA positive hypertensive iritis. ( 16200055 )
2006
26
An outbreak of iritis and uveitis in dairy cattle at pasture associated with the supplementary feeding of baleage. ( 16751847 )
2006
27
Iritis presumed as secondary to disseminated coccidioidomycosis. ( 17145566 )
2006
28
Towards evidence-based emergency medicine: best BETs from the Manchester Royal Infirmary. Does a normal-shaped pupil exclude the diagnosis of iritis. ( 17057143 )
2006
29
Recurrent iritis after implantation of an iris-fixated phakic intraocular lens for the correction of myopia Case report and clinicopathologic correlation. ( 16863980 )
2006
30
Effect of etanercept on iritis in patients with ankylosing spondylitis. ( 15529379 )
2004
31
Clinically unsuspected diffuse uveal melanoma presenting as recurrent iritis. ( 15327114 )
2004
32
The interrelationship between sex, susceptibility factors, and outcome in ankylosing spondylitis and its associated disorders including inflammatory bowel disease, psoriasis, and iritis. ( 12966615 )
2003
33
Placement of a collagen glaucoma drainage device to control intraocular pressure and chronic iritis secondary to juvenile rheumatoid arthritis. ( 12027105 )
2002
34
Blockage of complement regulators in the conjunctiva and within the eye leads to massive inflammation and iritis. ( 11899428 )
2001
35
Pouchitis-associated iritis (uveitis) following total proctocolectomy and ileal pouch-to-anal anastomosis in ulcerative colitis. ( 11240384 )
2001
36
Diffuse lamellar keratitis associated with iritis 10 months after laser in situ keratomileusis. ( 11489588 )
2001
37
Blau syndrome (familial granulomatous arthritis, iritis, and rash) in an african-american family. ( 19078446 )
2000
38
Iritis associated with Sweet's syndrome. ( 10971503 )
2000
39
Expression of stress-response protein 60 in iritis associated with experimental autoimmune encephalomyelitis. ( 10672873 )
1999
40
Intravenous cidofovir-induced iritis. ( 10028099 )
1999
41
Iritis associated with intravenous cidofovir. ( 10084411 )
1999
42
Low-dose methotrexate in the treatment of severe juvenile rheumatoid arthritis and sarcoid iritis. ( 10358815 )
1999
43
Cytomegalovirus iritis. ( 9824866 )
1998
44
Cataract surgery in a patient with severe chronic iritis and corneal endothelial damage. ( 9682104 )
1998
45
Blau syndrome of granulomatous arthritis, iritis, and skin rash: a new family and review of the literature. ( 9508240 )
1998
46
Sensorineural hearing loss, iritis and ankylosing spondylitis. ( 9973173 )
1998
47
Prevention of herpes simplex keratitis and iritis. ( 9488290 )
1998
48
Iritis and hypotony after treatment with intravenous cidofovir for cytomegalovirus retinitis. ( 9194724 )
1997
49
Recurrent iritis after intravenous administration of cidofovir. ( 9332544 )
1997
50
A controlled trial of oral acyclovir for the prevention of stromal keratitis or iritis in patients with herpes simplex virus epithelial keratitis. The Epithelial Keratitis Trial. The Herpetic Eye Disease Study Group. ( 9194719 )
1997

Variations for Iritis

Expression for Iritis

Search GEO for disease gene expression data for Iritis.

Pathways for Iritis

Pathways related to Iritis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.82 CD40LG TNFRSF1B
2 10.14 CD40LG TNFRSF1B

GO Terms for Iritis

Cellular components related to Iritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 8.92 CD40LG EPO HLA-B PHB2

Biological processes related to Iritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of intracellular estrogen receptor signaling pathway GO:0033147 8.62 CNOT1 PHB2

Molecular functions related to Iritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 estrogen receptor binding GO:0030331 8.62 CNOT1 PHB2

Sources for Iritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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