Aliases & Classifications for Iritis

Aliases & Descriptions for Iritis:

Name: Iritis 12 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:1406
MeSH 42 D007500
NCIt 47 C50621
SNOMED-CT 64 65074000
UMLS 69 C0022081

Summaries for Iritis

MalaCards based summary : Iritis is related to endotheliitis and norrie disease. An important gene associated with Iritis is EPO (Erythropoietin), and among its related pathways/superpathways are Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway and Inflammatory Response Pathway. The drugs Acyclovir and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and testes, and related phenotype is Increased shRNA abundance.

Wikipedia : 71 Uveitis is the inflammation of the uvea, the pigmented layer that lies between the inner retina and the... more...

Related Diseases for Iritis

Diseases related to Iritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 113)
id Related Disease Score Top Affiliating Genes
1 endotheliitis 11.2
2 norrie disease 11.0
3 hypersensitivity syndrome, carbamazepine-induced 10.8
4 parasitic conjunctivitis 10.2 EPO MRAP
5 epididymo-orchitis 10.2 HLA-B MRAP
6 tonsillitis 10.2 HLA-B MRAP
7 tick-borne relapsing fever 10.2 MRAP PHB2
8 acute maxillary sinusitis 10.1 MRAP PHB2
9 vibratory urticaria 10.1 MRAP PHB2
10 cystic kidney disease 10.1 MRAP PHB2
11 occupational dermatitis 10.1 MRAP TNFRSF1B
12 croup 10.1 MRAP TNFRSF1B
13 bladder calculus 10.1 MRAP TNFRSF1B
14 nephronophthisis 1, juvenile 10.1 MRAP TNFRSF1B
15 inclusion conjunctivitis 10.1 MRAP TNFRSF1B
16 patau syndrome 10.0 MRAP TNFRSF1B
17 diabetic peripheral angiopathy 10.0 CD40LG MRAP
18 angiolipoma 10.0 CD40LG MRAP
19 spondylitis 10.0
20 hyperparathyroidism, neonatal 10.0 EPO HLA-B SRP72
21 primary thrombocytopenia 10.0 CD40LG MRAP
22 arthritis 10.0
23 vulvovaginal candidiasis 10.0 CD40LG MRAP
24 tularemia 10.0 CD40LG MRAP
25 intravascular angioleiomyoma 10.0 CD40LG MRAP
26 pancreatic serous cystadenoma 10.0 CD40LG MRAP
27 chronic erythremia 10.0 CD40LG HLA-B
28 anthracosis 10.0 CD40LG MRAP
29 disease of mental health 10.0 CD40LG HLA-B
30 keratitis 10.0
31 spastic entropion 9.9 CD40LG PHB2
32 dermatitis herpetiformis 9.9 CD40LG TNFRSF1B
33 herpes simplex 9.9
34 thrombophlebitis migrans 9.9 CD40LG TNFRSF1B
35 anterior foramen magnum meningioma 9.9 CD40LG EPO HLA-B
36 hypopituitarism 9.9 CD40LG HLA-B MRAP
37 fetal hemoglobin quantitative trait locus 1 9.9 CD40LG EPO
38 acinic cell breast carcinoma 9.9 CD40LG TNFRSF1B
39 hypopyon 9.9
40 cataract 9.9
41 hypertrophic elongation of cervix 9.9 CD40LG TNFRSF1B
42 parasitic helminthiasis infectious disease 9.9 CD40LG HLA-B
43 basilar artery occlusion 9.8 CD40LG MRAP PHB2
44 vulvar sarcoma 9.8 CD40LG MRAP PHB2
45 hairy tongue 9.8 CD40LG MRAP PHB2
46 multinodular goiter 9.8 CD40LG TNFRSF1B
47 lymph node adenoid cystic carcinoma 9.8 CD40LG TNFRSF1B
48 endobronchial leiomyoma 9.8 CD40LG HLA-B TNFRSF1B
49 syphilis 9.8
50 uveitis 9.8

Graphical network of the top 20 diseases related to Iritis:



Diseases related to Iritis

Symptoms & Phenotypes for Iritis

GenomeRNAi Phenotypes related to Iritis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance GR00327-A 8.8 CNOT1 EPO HLA-B

Drugs & Therapeutics for Iritis

Drugs for Iritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 61)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Acyclovir Phase 4
2 Anti-Infective Agents Phase 4
3 Antiviral Agents Phase 4
4 valacyclovir Phase 4
5
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
6
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
7
Difluprednate Approved Phase 2 23674-86-4 443936
8
Daclizumab Approved, Investigational Phase 2 152923-56-3
9
Triamcinolone Approved, Vet_approved Phase 2 124-94-7 31307
10
Ranibizumab Approved Phase 2 347396-82-1 459903
11
Bromfenac Approved July 1997 Phase 2 91714-94-2 60726
12 Antiemetics Phase 2
13 Anti-Inflammatory Agents Phase 2
14 Antineoplastic Agents, Hormonal Phase 2
15 Autonomic Agents Phase 2
16 Gastrointestinal Agents Phase 2
17 glucocorticoids Phase 2
18 Hormone Antagonists Phase 2
19 Hormones Phase 2
20 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
21 Methylprednisolone acetate Phase 2
22 Methylprednisolone Hemisuccinate Phase 2
23 Neuroprotective Agents Phase 2
24 Peripheral Nervous System Agents Phase 2
25 Prednisolone acetate Phase 2
26 Prednisolone hemisuccinate Phase 2
27 Prednisolone phosphate Phase 2
28 Protective Agents Phase 2
29 Fluprednisolone Phase 2
30 Antibodies Phase 2
31 Immunoglobulin G Phase 2
32 Immunoglobulins Phase 2
33 Immunosuppressive Agents Phase 2
34 triamcinolone acetonide Phase 2
35 Triamcinolone diacetate Phase 2
36 Triamcinolone hexacetonide Phase 2
37 Analgesics Phase 2
38 Analgesics, Non-Narcotic Phase 2
39 Angiogenesis Inhibitors Phase 2
40 Angiogenesis Modulating Agents Phase 2
41 Anti-Inflammatory Agents, Non-Steroidal Phase 2
42 Antirheumatic Agents Phase 2
43 Ophthalmic Solutions Phase 2
44
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 5743
45
Diclofenac Approved, Vet_approved 15307-86-5 3033
46
Ephedrine Approved 299-42-3 9294
47
Pseudoephedrine Approved 90-82-4 7028
48 BB 1101
49 Cathartics
50 Cyclooxygenase Inhibitors

Interventional clinical trials:

(show all 12)
id Name Status NCT ID Phase
1 Aurolab Hydrophobic Foldable Intraocular Lens Study Completed NCT00449267 Phase 4
2 Zoster Eye Disease Study Not yet recruiting NCT03134196 Phase 4
3 Use of Topical Euphrasia, a Homeopathic Remedy in Ophthalmology Unknown status NCT02416128 Phase 2
4 Study of Difluprednate Ophthalmic Emulsion in the Treatment of Uveitis Completed NCT00405496 Phase 2
5 Human Anti-Tac (Daclizumab) to Treat Juvenile Idiopathic Arthritis (JIA)-Associated Uveitis Completed NCT00130637 Phase 2
6 Combination Ranibizumab and Bromfenac for Neovascular Age-related Macular Degeneration Completed NCT00805233 Phase 2
7 The Safety and Efficacy of Chicken Type II Collagen on Uveitis Associated With Juvenile Rheumatoid Arthritis Completed NCT00001614 Phase 1
8 PEMF: an Adjunct Therapy for Anterior Uveitis Completed NCT01154010
9 Evaluation and Treatment of Patients With Inflammatory Eye Diseases Completed NCT00006188
10 Retinal OCT and (mfERG) Related to Age, Sex, and the Use of Anti-inflammatory Medications Completed NCT00476593
11 Screening for NEI Clinical Studies Completed NCT00001734
12 To Evaluate Eye Installation-Tear Free Completed NCT02802917

Search NIH Clinical Center for Iritis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: iritis

Genetic Tests for Iritis

Anatomical Context for Iritis

MalaCards organs/tissues related to Iritis:

39
Eye, Retina, Testes, Endothelial, Skin

Publications for Iritis

Articles related to Iritis:

(show top 50) (show all 230)
id Title Authors Year
1
Chronic iritis associated with cutaneous leukocytoclastic vasculitis. ( 25939124 )
2015
2
Iritis, glaucoma and corneal decompensation associated with BrightOcular cosmetic iris implant. ( 26719491 )
2015
3
Intravitreal aflibercept after bilateral bevacizumab-induced iritis. ( 25871873 )
2015
4
Free-Floating Iris Cyst in a Patient with Recurrent Iritis. ( 26120316 )
2015
5
Bilateral Iritis after Vaccine for Bladder Cancer. ( 26258277 )
2015
6
Corneal Endothelial Cell Loss and Iritis Associated With a New Cosmetic Iris Implant. ( 25811391 )
2015
7
Intense pulsed light therapy (IPL) induced iritis following treatment for a medial canthal capillary malformation. ( 24417640 )
2014
8
Bilateral acute pyogenic conjunctivitis with iritis induced by unilateral topical application of bacterial peptidoglycan muramyl dipeptide in adult rabbits. ( 24135297 )
2013
9
Visante OCT in the diagnosis of caterpillar-induced iritis. ( 23931492 )
2013
10
Images in emergency medicine. Young boy with eye pain. Herpes zoster ophthalmicus, varicella zoster stromal keratitis, episcleritis and iritis. ( 23089088 )
2012
11
Restrictive (Mechanical) Strabismus: An Epidemic? DNA or Not, Twins Faces, Texas, DRS, Iritis Monitoring. ( 22747761 )
2012
12
Lay Person Slit Lamp Detection of Iritis in Absence of an Eye MD: Test of a Portable Model of Cells and Flare. ( 22747766 )
2012
13
Iritis and iris atrophy after eyebrow epilation with alexandrite laser. ( 22205833 )
2011
14
Iritis and pupillary distortion after periorbital cosmetic alexandrite laser. ( 21057804 )
2011
15
Cystoid macular edema after cataract surgery in a patient with previous severe iritis following argon laser peripheral iridoplasty. ( 21573094 )
2011
16
Novel molecular imaging approach for subclinical detection of iritis and evaluation of therapeutic success. ( 20581051 )
2010
17
Iritis, ptosis, and sequential severe loss of vision in a patient with essential thrombocytosis. ( 19696799 )
2010
18
Iritis and iris neoplasm as the presenting signs of esophageal squamous cell carcinoma. ( 19606176 )
2009
19
Severe iritis and choroidal effusion following selective laser trabeculoplasty. ( 18831426 )
2008
20
Latanoprost induced iritis after vitrectomy surgery. ( 25390234 )
2007
21
Bilateral ankle edema with bilateral iritis. ( 16633708 )
2007
22
Hypopyon iritis after primary fresh amniotic membrane transplantation. ( 18043192 )
2007
23
Herpetic keratitis with iritis after corneal crosslinking with riboflavin and ultraviolet A for keratoconus. ( 17964410 )
2007
24
Towards evidence-based emergency medicine: best BETs from the Manchester Royal Infirmary. Does a normal-shaped pupil exclude the diagnosis of iritis. ( 17057143 )
2006
25
Recurrent iritis after implantation of an iris-fixated phakic intraocular lens for the correction of myopia Case report and clinicopathologic correlation. ( 16863980 )
2006
26
An outbreak of iritis and uveitis in dairy cattle at pasture associated with the supplementary feeding of baleage. ( 16751847 )
2006
27
Intravitreal ganciclovir injections in aqueous cytomegalovirus DNA positive hypertensive iritis. ( 16200055 )
2006
28
Iritis presumed as secondary to disseminated coccidioidomycosis. ( 17145566 )
2006
29
Clinically unsuspected diffuse uveal melanoma presenting as recurrent iritis. ( 15327114 )
2004
30
Effect of etanercept on iritis in patients with ankylosing spondylitis. ( 15529379 )
2004
31
The interrelationship between sex, susceptibility factors, and outcome in ankylosing spondylitis and its associated disorders including inflammatory bowel disease, psoriasis, and iritis. ( 12966615 )
2003
32
Placement of a collagen glaucoma drainage device to control intraocular pressure and chronic iritis secondary to juvenile rheumatoid arthritis. ( 12027105 )
2002
33
Blockage of complement regulators in the conjunctiva and within the eye leads to massive inflammation and iritis. ( 11899428 )
2001
34
Diffuse lamellar keratitis associated with iritis 10 months after laser in situ keratomileusis. ( 11489588 )
2001
35
Pouchitis-associated iritis (uveitis) following total proctocolectomy and ileal pouch-to-anal anastomosis in ulcerative colitis. ( 11240384 )
2001
36
Iritis associated with Sweet's syndrome. ( 10971503 )
2000
37
Blau syndrome (familial granulomatous arthritis, iritis, and rash) in an african-american family. ( 19078446 )
2000
38
Intravenous cidofovir-induced iritis. ( 10028099 )
1999
39
Expression of stress-response protein 60 in iritis associated with experimental autoimmune encephalomyelitis. ( 10672873 )
1999
40
Low-dose methotrexate in the treatment of severe juvenile rheumatoid arthritis and sarcoid iritis. ( 10358815 )
1999
41
Iritis associated with intravenous cidofovir. ( 10084411 )
1999
42
Prevention of herpes simplex keratitis and iritis. ( 9488290 )
1998
43
Blau syndrome of granulomatous arthritis, iritis, and skin rash: a new family and review of the literature. ( 9508240 )
1998
44
Sensorineural hearing loss, iritis and ankylosing spondylitis. ( 9973173 )
1998
45
Cytomegalovirus iritis. ( 9824866 )
1998
46
Cataract surgery in a patient with severe chronic iritis and corneal endothelial damage. ( 9682104 )
1998
47
A controlled trial of oral acyclovir for the prevention of stromal keratitis or iritis in patients with herpes simplex virus epithelial keratitis. The Epithelial Keratitis Trial. The Herpetic Eye Disease Study Group. ( 9194719 )
1997
48
Iritis and hypotony after treatment with intravenous cidofovir for cytomegalovirus retinitis. ( 9194724 )
1997
49
Recurrent iritis after intravenous administration of cidofovir. ( 9332544 )
1997
50
Iritis. How to recognize and manage a potentially sight-threatening disease. ( 8632971 )
1996

Variations for Iritis

Expression for Iritis

Search GEO for disease gene expression data for Iritis.

Pathways for Iritis

Pathways related to Iritis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
10.82 CD40LG TNFRSF1B
2 10.14 CD40LG TNFRSF1B

GO Terms for Iritis

Cellular components related to Iritis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 8.92 CD40LG EPO HLA-B PHB2

Biological processes related to Iritis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 negative regulation of intracellular estrogen receptor signaling pathway GO:0033147 8.62 CNOT1 PHB2

Molecular functions related to Iritis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 estrogen receptor binding GO:0030331 8.62 CNOT1 PHB2

Sources for Iritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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