MCID: IRT001
MIFTS: 41

Iritis malady

Summaries for Iritis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Uveitis is, broadly, inflammation of the uvea. The uvea consists of the middle, pigmented vascular... more...

MalaCards: Iritis is related to arthritis and ankylosing spondylitis. An important gene associated with Iritis is PRND (prion protein 2 (dublet)), and among its related pathways are Primary immunodeficiency and Immune response Fc epsilon RI pathway. The drugs tropicamide and loteprednol etabonate and the compounds okt3 and sulfolipid i have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and skin.

Aliases & Classifications for Iritis

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Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
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Aliases & Descriptions:

iritis 8 10 60


External Ids:

Disease Ontology8 DOID:1406
NCIt39 C50621
SNOMED-CT56 65074000
MeSH34 D007500

Related Diseases for Iritis

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Iritis:



Diseases related to iritis

Clinical Features for Iritis

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Drugs & Therapeutics for Iritis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Iritis

Drug clinical trials:

Search ClinicalTrials for Iritis

Search NIH Clinical Center for Iritis

Search CenterWatch for Iritis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Iritis

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Anatomical Context for Iritis

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Sources:
32MalaCards
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MalaCards organs/tissues related to Iritis:

32
Eye, Testes, Skin, Retina, Endothelial

Animal Models for Iritis or affiliated genes

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Publications for Iritis

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Sources:
50PubMed
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Articles related to Iritis:

(show top 50)    (show all 223)
idTitleAuthorsYear
1
Iritis-Rheumatic and ToxA (20902618)
mic.
2
Lay Person Slit Lamp Detection of Iritis in Absence of an Eye MD: Test of a Portable Model of Cells and Flare. (22747766)
2012
3
Iritis and pupillary distortion after periorbital cosmetic alexandrite laser. (21057804)
2011
4
Iritis and iris neoplasm as the presenting signs of esophageal squamous cell carcinoma. (19606176)
2009
5
Severe iritis and choroidal effusion following selective laser trabeculoplasty. (18831426)
2008
6
Hypopyon iritis after primary fresh amniotic membrane transplantation. (18043192)
2007
7
Intravitreal ganciclovir injections in aqueous cytomegalovirus DNA positive hypertensive iritis. (16200055)
2006
8
Effect of etanercept on iritis in patients with ankylosing spondylitis. (15529379)
2004
9
Blau syndrome (familial granulomatous arthritis, iritis, and rash) in an african-american family. (19078446)
2000
10
Iritis associated with intravenous cidofovir. (10084411)
1999
11
Sensorineural hearing loss, iritis and ankylosing spondylitis. (9973173)
1998
12
Iritis and hypotony after treatment with intravenous cidofovir for cytomegalovirus retinitis. (9194724)
1997
13
A controlled trial of oral acyclovir for the prevention of stromal keratitis or iritis in patients with herpes simplex virus epithelial keratitis. The Epithelial Keratitis Trial. The Herpetic Eye Disease Study Group. (9194719)
1997
14
Recurrent iritis after intravenous administration of cidofovir. (9332544)
1997
15
Recognition of iritis. (8636691)
1996
16
Iritis following intravenous pamidronate. (8811218)
1996
17
Bisphosphonates and iritis. (8094197)
1993
18
Acute granulomatous iritis following 5 fluorouracil therapy for failed trabeculectomy. (1841886)
1991
19
Cocaine-induced iritis. (1996804)
1991
20
Iritis in children with varicella. (2391625)
1990
21
Early-onset pauciarticular juvenile rheumatoid arthritis associated with human leukocyte antigen-DRw5, iritis, and antinuclear antibody. (6967490)
1980
22
Inhibition of prostaglandin-induced iritis. Topical indoxole vs indomethacin therapy. (7387517)
1980
23
Diagnostic ultrasound in cases of acute iritis. (306769)
1978
24
Iritis in Reiter's disease: an example of the Auer principle. (737166)
1978
25
Effect of propranolol and phenylbutazone on the prostaglandin like activity of the rabbit's iris in endotoxin induced iritis. (1031135)
1976
26
Isolation of herpes simplex virus from the aqueous humour in herpetic kerato-iritis. (199302)
1976
27
Uncommon complications of early syphilis. Hepatitis, periostitis, iritis with papillitis, and meningitis. (5015962)
1972
28
Staphylococcal hypersensitivity and iritis. (4974838)
1969
29
Secondary iritis in homocystinuria. (5715662)
1968
30
Pathology of Herpes Simplex Kerato-Iritis. (16693633)
1963
31
A case of gouty iritis. (13915558)
1962
32
Preventable blindness: iritis. (14486093)
1961
33
Phenylbutazone in treatment of postoperative iritis. (13813750)
1960
34
Leprous iritis with hypopyon. (13458309)
1957
35
Iritis as the presenting symptom in ankylosing spondylitis. (14874516)
1951
36
Subconjunctival injection of cortisone in iritis. (14778735)
1950
37
Rheumatoid iritis. (18905681)
1948
38
Bilateral iritis due to sarcoidosis. (21065045)
1946
39
The role of lens substance in experimental gonorrheal iritis. (21000616)
1946
40
IRITIS IN FOWLS. (18169673)
1940
41
IRITIS (WHITE EYE) IN FOWLS: With an account of the Histological Changes in the Eye. (18169656)
1939
42
Experimental Iritis: The Ocular Reactions in Rabbits Sensitized to Streptococcus Viridans. (16693101)
1936
43
The Etiology and Treatment of Endogenous Iritis: An Analysis of 100 Consecutive Cases in Private Practice. (16692713)
1925
44
Case of "Gassing" followed by Tubercular Iritis. (19981301)
1920
45
DISCUSSION ON THE A8TIOLOGY AND TREATMENT OF IRITIS. (20904267)
1917
46
DISCUSSION ON THE AETIOLOGY AND TREATMENT OF IRITIS. (19979869)
1917
47
DISCUSSION ON THE A8TIOLOGY AND TREATMENT OF IRITIS. (20904266)
1917
48
THE ETIOLOGY OF IRITIS. (20765363)
1910
49
REMARKS ON IRITIS, WITH SPECIAL REFERENCE TO GONORRHOEAL IRITIS. (20763965)
1908
50
Iridectomy in Chronic Iritis. (16691765)
1884

Genetic Variations for Iritis

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Expression for genes affiliated with Iritis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Iritis

Search GEO for disease gene expression data for Iritis.

Pathways for genes affiliated with Iritis

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Sources:
29KEGG, 12EMD Millipore
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Compounds for genes affiliated with Iritis

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Iritis according to GeneCards/GeneDecks:

(show all 36)
idCompoundScoreTop Affiliating Genes
1okt34410.2CD40LG
2sulfolipid i449.7CD79A, CD40LG
3sandoglobulin449.7CD79A, CD40LG
4vancomycin44 1110.7CD79A, CD40LG
5blys449.7CD79A, CD40LG
6tuberculin449.7CD40LG, CD79A
7praziquantel44 1110.7CD40LG, CD79A
8hemocyanin449.7CD79A, CD40LG
9gliadin449.6CD79A, CD40LG
10pmma449.6CD79A, CD40LG
11silicone449.6CD40LG, CD79A
12mannan449.6CD79A, CD40LG
13ursodeoxycholic acid44 11 2411.5HLA-B, CD40LG
14glutaraldehyde449.5CD79A, CD40LG
15sulfasalazine44 28 49 1112.5CD40LG, CD79A
16valproate449.4CD79A, CD40LG
17cytidine44 11 2411.3CD40LG, CD79A
18anti-fungal449.3CD79A, CD40LG
19pneumococcal449.2CD79A, CD40LG, HLA-B
20phenytoin44 49 28 1112.2HLA-B, CD40LG, CD79A
21polysaccharide449.0CD79A, CD40LG, HLA-B
22cimetidine44 28 1111.0HLA-B, EPO
23ribavirin44 49 1111.0EPO, CD40LG, HLA-B
24fibrinogen449.0CD79A, CD40LG, HLA-B
25mycophenolate mofetil44 49 1110.9CD40LG, CD79A, EPO
26doxycycline44 119.9CD40LG, CD79A, EPO
27vitamin b12448.9EPO, CD79A, CD40LG
28theophylline44 28 11 2411.9CD40LG, CD79A, EPO
29folate448.8EPO, CD79A, CD40LG
30pge2448.8HLA-B, CD40LG, CD79A, PLA2G2D
31ascorbic acid44 249.8EPO, CD79A, CD40LG
32paraffin448.5CD79A, CD40LG, HLA-B
33cyclosporin a44 28 5910.4EPO, CD79A, CD40LG, HLA-B
34lactate448.4HLA-B, CD40LG, CD79A, EPO
35creatinine448.3HLA-B, CD40LG, CD79A, EPO
36testosterone44 59 11 2411.3HLA-B, CD40LG, CD79A, EPO

GO Terms for genes affiliated with Iritis

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16Gene Ontology
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Cellular components related to Iritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058867.6SRP72, CD79A, CD40LG, PRND, HLA-B, MRAP

Biological processes related to Iritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1B cell differentiationGO:0301839.3CD79A, CD40LG
2B cell proliferationGO:0421009.0CD79A, CD40LG

Products for genes affiliated with Iritis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Iritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet