Aliases & Classifications for Iritis

MalaCards integrated aliases for Iritis:

Name: Iritis 12 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:1406
MeSH 42 D007500
NCIt 47 C50621
SNOMED-CT 64 65074000
UMLS 69 C0022081

Summaries for Iritis

MalaCards based summary : Iritis is related to endotheliitis and norrie disease. An important gene associated with Iritis is HLA-B (Major Histocompatibility Complex, Class I, B), and among its related pathways/superpathways are TNF Superfamily Pathway: Human Ligand-Receptor Interactions and their Associated Functions and Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway. The drugs Acyclovir and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and testes, and related phenotype is Increased shRNA abundance.

Wikipedia : 72 Uveitis is the inflammation of the uvea, the pigmented layer that lies between the inner retina and the... more...

Related Diseases for Iritis

Diseases related to Iritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 122)
id Related Disease Score Top Affiliating Genes
1 endotheliitis 11.2
2 norrie disease 11.0
3 hypersensitivity syndrome, carbamazepine-induced 10.8
4 lens-induced iridocyclitis 10.5 HLA-B MRAP
5 perforated corneal ulcer 10.5 HLA-B MRAP
6 parasitic conjunctivitis 10.5 EPO MRAP
7 tick-borne relapsing fever 10.4 MRAP PHB2
8 acute maxillary sinusitis 10.3 MRAP PHB2
9 urticaria 10.3 MRAP PHB2
10 kidney cortex necrosis 10.3 MRAP PHB2
11 neuronal ceroid-lipofuscinoses 10.3 MRAP PHB2
12 glaucomatocyclitic crisis 10.2 MRAP TNFRSF1B
13 bladder calculus 10.2 MRAP TNFRSF1B
14 dermatosis papulosa nigra 10.2 MRAP TNFRSF1B
15 primary lacrimal atrophy 10.2 MRAP TNFRSF1B
16 inclusion conjunctivitis 10.2 MRAP TNFRSF1B
17 patau syndrome 10.1 MRAP TNFRSF1B
18 malignant hypertensive renal disease 10.1 CD40LG MRAP
19 infiltrating angiolipoma 10.1 CD40LG MRAP
20 hypocalciuric hypercalcemia, type i 10.1 EPO HLA-B SRP72
21 chronic inflammatory demyelinating polyneuritis 10.0 CD40LG EPO
22 spondylitis 10.0
23 mitochondrial encephalomyopathy 10.0 CD40LG MRAP
24 chronic erythremia 10.0 CD40LG HLA-B
25 arthritis 10.0
26 vulvovaginal candidiasis 10.0 CD40LG MRAP
27 pancreatic cystadenoma 10.0 CD40LG MRAP
28 tularemia 10.0 CD40LG MRAP
29 angiomyoma 10.0 CD40LG MRAP
30 caplan's syndrome 10.0 CD40LG MRAP
31 keratitis 10.0
32 disease of mental health 9.9 CD40LG HLA-B
33 endometrial clear cell adenocarcinoma 9.9 MRAP TNFRSF1B
34 herpes simplex 9.9
35 eye carcinoma in situ 9.9 CD40LG HLA-B
36 acute cholangitis 9.9 CD40LG HLA-B
37 hypopyon 9.9
38 cataract 9.9
39 thalassemia-beta, dominant inclusion-body 9.8 CD40LG EPO
40 emphysema, congenital lobar 9.8 CD40LG HLA-B
41 lung disease 9.8 CD40LG TNFRSF1B
42 syphilis 9.8
43 uveitis 9.8
44 spastic entropion 9.8 CD40LG PHB2
45 acral lentiginous melanoma 9.8 CD40LG EPO HLA-B
46 isthmus cancer 9.8 CD40LG HLA-B
47 retinitis 9.8
48 diabetic autonomic neuropathy 9.8
49 autonomic neuropathy 9.8
50 herpes zoster ophthalmicus 9.8

Graphical network of the top 20 diseases related to Iritis:



Diseases related to Iritis

Symptoms & Phenotypes for Iritis

GenomeRNAi Phenotypes related to Iritis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance GR00327-A 8.8 CNOT1 EPO HLA-B

Drugs & Therapeutics for Iritis

Drugs for Iritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 60)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Acyclovir Phase 4
2 Anti-Infective Agents Phase 4
3 Antiviral Agents Phase 4
4 valacyclovir Phase 4
5
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
6
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
7
Difluprednate Approved Phase 2 23674-86-4 443936
8
Daclizumab Approved, Investigational Phase 2 152923-56-3
9
Triamcinolone Approved, Vet_approved Phase 2 124-94-7 31307
10
Ranibizumab Approved Phase 2 347396-82-1 459903
11
Bromfenac Approved July 1997 Phase 2 91714-94-2 60726
12 Antiemetics Phase 2
13 Anti-Inflammatory Agents Phase 2
14 Antineoplastic Agents, Hormonal Phase 2
15 Autonomic Agents Phase 2
16 Gastrointestinal Agents Phase 2
17 glucocorticoids Phase 2
18 Hormone Antagonists Phase 2
19 Hormones Phase 2
20 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
21 Methylprednisolone acetate Phase 2
22 Methylprednisolone Hemisuccinate Phase 2
23 Neuroprotective Agents Phase 2
24 Peripheral Nervous System Agents Phase 2
25 Prednisolone acetate Phase 2
26 Prednisolone hemisuccinate Phase 2
27 Prednisolone phosphate Phase 2
28 Protective Agents Phase 2
29 Fluprednisolone Phase 2
30 Antibodies Phase 2
31 Immunoglobulins Phase 2
32 Immunosuppressive Agents Phase 2
33 triamcinolone acetonide Phase 2
34 Triamcinolone diacetate Phase 2
35 Triamcinolone hexacetonide Phase 2
36 Analgesics Phase 2
37 Analgesics, Non-Narcotic Phase 2
38 Angiogenesis Inhibitors Phase 2
39 Angiogenesis Modulating Agents Phase 2
40 Anti-Inflammatory Agents, Non-Steroidal Phase 2
41 Antirheumatic Agents Phase 2
42 Ophthalmic Solutions Phase 2
43
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 5743
44
Diclofenac Approved, Vet_approved 15307-86-5 3033
45
Ephedrine Approved 299-42-3 9294
46
Pseudoephedrine Approved 90-82-4 7028
47
Lactitol Investigational 585-86-4 3871
48 BB 1101
49 Cathartics
50 Cyclooxygenase Inhibitors

Interventional clinical trials:

(show all 12)

id Name Status NCT ID Phase Drugs
1 Aurolab Hydrophobic Foldable Intraocular Lens Study Completed NCT00449267 Phase 4
2 Zoster Eye Disease Study Recruiting NCT03134196 Phase 4 Masked Placebo;Masked Oral Valacyclovir
3 Use of Topical Euphrasia, a Homeopathic Remedy in Ophthalmology Unknown status NCT02416128 Phase 2 Euphrasia;Prednisolone acetate
4 Study of Difluprednate Ophthalmic Emulsion in the Treatment of Uveitis Completed NCT00405496 Phase 2 Difluprednate Ophthalmic Emulsion
5 Human Anti-Tac (Daclizumab) to Treat Juvenile Idiopathic Arthritis (JIA)-Associated Uveitis Completed NCT00130637 Phase 2 Daclizumab
6 Combination Ranibizumab and Bromfenac for Neovascular Age-related Macular Degeneration Completed NCT00805233 Phase 2 combination ranibizumab + bromfenac;ranibizumab injection alone
7 The Safety and Efficacy of Chicken Type II Collagen on Uveitis Associated With Juvenile Rheumatoid Arthritis Completed NCT00001614 Phase 1 Chicken type II collagen
8 PEMF: an Adjunct Therapy for Anterior Uveitis Completed NCT01154010
9 Evaluation and Treatment of Patients With Inflammatory Eye Diseases Completed NCT00006188
10 Retinal OCT and (mfERG) Related to Age, Sex, and the Use of Anti-inflammatory Medications Completed NCT00476593 Diclofenac;Dexamethasone
11 Screening for NEI Clinical Studies Completed NCT00001734
12 To Evaluate Eye Installation-Tear Free Completed NCT02802917 SPF 50 Y49 091 (BAY 987516);SPF 50 X15 158 (BAY 987516);SPF 50 X15 160 (BAY 987516);SPF 50 X57 162 (BAY 987516)

Search NIH Clinical Center for Iritis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: iritis

Genetic Tests for Iritis

Anatomical Context for Iritis

MalaCards organs/tissues related to Iritis:

39
Eye, Retina, Testes, Skin, Endothelial

Publications for Iritis

Articles related to Iritis:

(show top 50) (show all 231)
id Title Authors Year
1
Iritis ( 28613659 )
2017
2
Free-Floating Iris Cyst in a Patient with Recurrent Iritis. ( 26120316 )
2015
3
Iritis, glaucoma and corneal decompensation associated with BrightOcular cosmetic iris implant. ( 26719491 )
2015
4
Corneal Endothelial Cell Loss and Iritis Associated With a New Cosmetic Iris Implant. ( 25811391 )
2015
5
Intravitreal aflibercept after bilateral bevacizumab-induced iritis. ( 25871873 )
2015
6
Chronic iritis associated with cutaneous leukocytoclastic vasculitis. ( 25939124 )
2015
7
Bilateral Iritis after Vaccine for Bladder Cancer. ( 26258277 )
2015
8
Intense pulsed light therapy (IPL) induced iritis following treatment for a medial canthal capillary malformation. ( 24417640 )
2014
9
Bilateral acute pyogenic conjunctivitis with iritis induced by unilateral topical application of bacterial peptidoglycan muramyl dipeptide in adult rabbits. ( 24135297 )
2013
10
Visante OCT in the diagnosis of caterpillar-induced iritis. ( 23931492 )
2013
11
Restrictive (Mechanical) Strabismus: An Epidemic? DNA or Not, Twins Faces, Texas, DRS, Iritis Monitoring. ( 22747761 )
2012
12
Lay Person Slit Lamp Detection of Iritis in Absence of an Eye MD: Test of a Portable Model of Cells and Flare. ( 22747766 )
2012
13
Images in emergency medicine. Young boy with eye pain. Herpes zoster ophthalmicus, varicella zoster stromal keratitis, episcleritis and iritis. ( 23089088 )
2012
14
Iritis and iris atrophy after eyebrow epilation with alexandrite laser. ( 22205833 )
2011
15
Iritis and pupillary distortion after periorbital cosmetic alexandrite laser. ( 21057804 )
2011
16
Cystoid macular edema after cataract surgery in a patient with previous severe iritis following argon laser peripheral iridoplasty. ( 21573094 )
2011
17
Novel molecular imaging approach for subclinical detection of iritis and evaluation of therapeutic success. ( 20581051 )
2010
18
Iritis, ptosis, and sequential severe loss of vision in a patient with essential thrombocytosis. ( 19696799 )
2010
19
Iritis and iris neoplasm as the presenting signs of esophageal squamous cell carcinoma. ( 19606176 )
2009
20
Severe iritis and choroidal effusion following selective laser trabeculoplasty. ( 18831426 )
2008
21
Hypopyon iritis after primary fresh amniotic membrane transplantation. ( 18043192 )
2007
22
Latanoprost induced iritis after vitrectomy surgery. ( 25390234 )
2007
23
Herpetic keratitis with iritis after corneal crosslinking with riboflavin and ultraviolet A for keratoconus. ( 17964410 )
2007
24
Bilateral ankle edema with bilateral iritis. ( 16633708 )
2007
25
Recurrent iritis after implantation of an iris-fixated phakic intraocular lens for the correction of myopia Case report and clinicopathologic correlation. ( 16863980 )
2006
26
Intravitreal ganciclovir injections in aqueous cytomegalovirus DNA positive hypertensive iritis. ( 16200055 )
2006
27
Towards evidence-based emergency medicine: best BETs from the Manchester Royal Infirmary. Does a normal-shaped pupil exclude the diagnosis of iritis. ( 17057143 )
2006
28
An outbreak of iritis and uveitis in dairy cattle at pasture associated with the supplementary feeding of baleage. ( 16751847 )
2006
29
Iritis presumed as secondary to disseminated coccidioidomycosis. ( 17145566 )
2006
30
Clinically unsuspected diffuse uveal melanoma presenting as recurrent iritis. ( 15327114 )
2004
31
Effect of etanercept on iritis in patients with ankylosing spondylitis. ( 15529379 )
2004
32
The interrelationship between sex, susceptibility factors, and outcome in ankylosing spondylitis and its associated disorders including inflammatory bowel disease, psoriasis, and iritis. ( 12966615 )
2003
33
Placement of a collagen glaucoma drainage device to control intraocular pressure and chronic iritis secondary to juvenile rheumatoid arthritis. ( 12027105 )
2002
34
Blockage of complement regulators in the conjunctiva and within the eye leads to massive inflammation and iritis. ( 11899428 )
2001
35
Diffuse lamellar keratitis associated with iritis 10 months after laser in situ keratomileusis. ( 11489588 )
2001
36
Pouchitis-associated iritis (uveitis) following total proctocolectomy and ileal pouch-to-anal anastomosis in ulcerative colitis. ( 11240384 )
2001
37
Iritis associated with Sweet's syndrome. ( 10971503 )
2000
38
Blau syndrome (familial granulomatous arthritis, iritis, and rash) in an african-american family. ( 19078446 )
2000
39
Expression of stress-response protein 60 in iritis associated with experimental autoimmune encephalomyelitis. ( 10672873 )
1999
40
Iritis associated with intravenous cidofovir. ( 10084411 )
1999
41
Intravenous cidofovir-induced iritis. ( 10028099 )
1999
42
Low-dose methotrexate in the treatment of severe juvenile rheumatoid arthritis and sarcoid iritis. ( 10358815 )
1999
43
Sensorineural hearing loss, iritis and ankylosing spondylitis. ( 9973173 )
1998
44
Prevention of herpes simplex keratitis and iritis. ( 9488290 )
1998
45
Cytomegalovirus iritis. ( 9824866 )
1998
46
Blau syndrome of granulomatous arthritis, iritis, and skin rash: a new family and review of the literature. ( 9508240 )
1998
47
Cataract surgery in a patient with severe chronic iritis and corneal endothelial damage. ( 9682104 )
1998
48
Recurrent iritis after intravenous administration of cidofovir. ( 9332544 )
1997
49
A controlled trial of oral acyclovir for the prevention of stromal keratitis or iritis in patients with herpes simplex virus epithelial keratitis. The Epithelial Keratitis Trial. The Herpetic Eye Disease Study Group. ( 9194719 )
1997
50
Iritis and hypotony after treatment with intravenous cidofovir for cytomegalovirus retinitis. ( 9194724 )
1997

Variations for Iritis

Expression for Iritis

Search GEO for disease gene expression data for Iritis.

Pathways for Iritis

GO Terms for Iritis

Cellular components related to Iritis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 8.92 CD40LG EPO HLA-B PHB2

Biological processes related to Iritis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 negative regulation of intracellular estrogen receptor signaling pathway GO:0033147 8.62 CNOT1 PHB2

Molecular functions related to Iritis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 estrogen receptor binding GO:0030331 8.62 CNOT1 PHB2

Sources for Iritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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