MCID: IRN001
MIFTS: 48

Iron Deficiency Anemia malady

Immune diseases, Blood diseases categories

Aliases & Classifications for Iron Deficiency Anemia

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Sources:
9Disease Ontology, 43Novoseek, 60UMLS, 55SNOMED-CT, 33MeSH, 27ICD9CM, 25ICD10
See all sources

Iron Deficiency Anemia, Aliases & Descriptions:

Name: Iron Deficiency Anemia 9 43 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases, Blood diseases


External Ids:

Disease Ontology9 DOID:11758
MeSH33 D018798
ICD9CM27 280.8
ICD1025 D50

Summaries for Iron Deficiency Anemia

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Wikipedia:63 Iron-deficiency anemia (or iron-deficiency anaemia) is a common anemia (low red blood cell or hemoglobin... more...

MalaCards based summary: Iron Deficiency Anemia is related to iron-refractory iron deficiency anemia and thrombocytosis. An important gene associated with Iron Deficiency Anemia is TMPRSS6 (transmembrane protease, serine 6), and among its related pathways are Iron metabolism in placenta and Insulin receptor recycling. The drugs iron-dextran complex and ferric oxide and the compounds anagrelide and pixy321 have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and small intestine, and related mouse phenotypes are liver/biliary system and cardiovascular system.

Related Diseases for Iron Deficiency Anemia

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Diseases related to Iron Deficiency Anemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 154)
idRelated DiseaseScoreTop Affiliating Genes
1iron-refractory iron deficiency anemia32.2TMPRSS6
2thrombocytosis31.3EPO, THPO
3deficiency anemia31.1TF, TFRC, THPO, TMPRSS6, EPO, HFE2
4thalassemia31.1EPO, TFRC, TF
5hemosiderosis30.9EPO, TF
6pancytopenia30.7EPO, THPO
7thrombocytopenia30.6EPO, THPO
8hypogonadism30.5TF
9splenomegaly30.5EPO, THPO
10restless legs syndrome30.4TFRC, TF
11microcytic anemia30.3TF, TFRC, EPO
12iron metabolism disease30.3HFE2, TF
13hemoglobinopathy30.2EPO, TFRC, TF
14sickle cell disease30.2EPO, TFRC, TF
15hemolytic anemia30.2TF, TFRC, EPO
16refractory anemia30.1EPO, THPO, TFRC
17hemochromatosis30.1TF, TFRC, HFE2
18celiac disease10.7
19inflammatory bowel disease10.7
20gastritis10.6
21cerebritis10.6
22kidney disease10.6
23hemangioma10.5
24retinitis10.5
25cavernous hemangioma10.4
26papilledema10.4
27arteriovenous fistula10.4EPO
28aceruloplasminemia10.4HFE2
29hypersplenism10.4THPO
30rheumatoid arthritis10.4
31peutz-jeghers syndrome10.4
32malaria10.4
33arthritis10.4
34atrophic gastritis10.4
35giardiasis10.4
36protein-losing enteropathy10.4
37duodenitis10.4
38adenoma10.4
39blue rubber bleb nevus syndrome10.4
40febrile seizures10.4
41cerebral sinovenous thrombosis10.4
42obesity10.3
43lipoma10.3
44migraine10.3
45hereditary hemorrhagic telangiectasia10.3
46retinal vein occlusion10.3
47central retinal vein occlusion10.3
48gastric antral vascular ectasia10.3
49intussusception10.3
50gastroduodenitis10.3

Graphical network of the top 20 diseases related to Iron Deficiency Anemia:



Diseases related to iron deficiency anemia

Symptoms for Iron Deficiency Anemia

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Drugs & Therapeutics for Iron Deficiency Anemia

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Genetic Tests for Iron Deficiency Anemia

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Anatomical Context for Iron Deficiency Anemia

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MalaCards organs/tissues related to Iron Deficiency Anemia:

31
Heart, Kidney, Small intestine, Colon, Testes, Bone, Neutrophil, Bone marrow, Placenta, Eye, Brain, Lung, Thyroid, Breast

Animal Models for Iron Deficiency Anemia or affiliated genes

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MGI Mouse Phenotypes related to Iron Deficiency Anemia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.5TFRC, HFE2, EPO, TMPRSS6
2MP:00053858.5EPO, TMPRSS6, TFRC, HFE2
3MP:00107718.4TFRC, TMPRSS6, EPO, HFE2
4MP:00053767.6HFE2, EPO, TMPRSS6, TFRC, TF
5MP:00107687.3EPO, TMPRSS6, TFRC, TF, HFE2
6MP:00053977.2EPO, HFE2, TMPRSS6, TF, TFRC, THPO

Publications for Iron Deficiency Anemia

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Articles related to Iron Deficiency Anemia:

(show top 50)    (show all 640)
idTitleAuthorsYear
1
Association between Iron Deficiency Anemia and Helicobacter Pylori Infection among Children Under Six Years in Iran. (25871019)
2015
2
Parenteral iron therapy in the treatment of iron deficiency anemia during pregnancy: a randomized controlled trial. (25772960)
2015
3
The relationship between iron deficiency anemia and simple febrile convulsion in children. (25250062)
2014
4
Treatment of iron-deficiency anemia in patients with subclinical hypothyroidism. (23582934)
2013
5
Prevalence and predictive factors for gastrointestinal pathology in young men evaluated for iron deficiency anemia. (23192647)
2013
6
Positive relationship between a polymorphism in Helicobacter pylori neutrophil-activating protein a gene and iron-deficiency anemia. (23067298)
2013
7
Effect of sequential versus standard Helicobacter pylori eradication therapy on the associated iron deficiency anemia in children. (24130381)
2013
8
Iron deficiency anemia in patients with inflammatory bowel disease. (23766655)
2013
9
Intravenous iron sucrose versus oral iron in treatment of iron deficiency anemia in pregnancy: a randomized clinical trial. (22925176)
2013
10
Iron deficiency anemia in infants: does it really affect the myocardial functions? (23387876)
2013
11
Rapid Assessment for Coexistence of Vitamin B12 and Iron Deficiency Anemia among Adolescent Males and Females in Northern Himalayan State of India. (23970962)
2013
12
Effect of iron deficiency anemia in pregnancy on child mental development in rural China. (23400604)
2013
13
Intravenous iron monotherapy for the treatment of non-iron-deficiency anemia in cancer patients undergoing chemotherapy: a pilot study. (24039403)
2013
14
Human serum transferrin: is there a link among autism, high oxalate levels, and iron deficiency anemia? (24152109)
2013
15
Refractory Iron-deficiency Anemia and Autoimmune Atrophic Gastritis in Pediatric Age Group: Analysis of 8 Clinical Cases. (24327126)
2013
16
Combined cobalamin and iron deficiency anemia: a diagnostic approach using a model based on age and homocysteine assessment. (23183879)
2013
17
Ferric carboxymaltose for the treatment of iron-deficiency anemia. [corrected]. (22413903)
2012
18
Efficacy of Trikatrayadi Lauha in Panduroga with reference to Iron Deficiency Anemia. (23049186)
2012
19
Dietary counseling for preventing iron deficiency anemia in infants in Brazil: something more is needed. (22344409)
2012
20
Effects of iron deficiency anemia and its treatment with iron polymaltose complex in pregnant rats, their fetuses and placentas: oxidative stress markers and pregnancy outcome. (22153683)
2012
21
Diagnostic yield of small-bowel capsule endoscopy in patients with iron-deficiency anemia: a systematic review. (23078923)
2012
22
Artificial intelligence models for predicting iron deficiency anemia and iron serum level based on accessible laboratory data. (21503744)
2012
23
Iron deficiency and iron-deficiency anemia in the first two years of life: strategies to prevent loss of developmental potential. (22043885)
2011
24
An unusual cause of iron deficiency anemia and abdominal pain in a young female. (21396329)
2011
25
Hereditary hyperferritinemia-cataract syndrome (HHCS) presenting with iron deficiency anemia associated with a new mutation in the iron responsive element of the L ferritin gene in a Swiss family. (21410535)
2011
26
A prospective evaluation of iron deficiency anemia in the GI endoscopy setting: role of standard endoscopy, videocapsule endoscopy, and CT-enteroclysis. (21396638)
2011
27
Iron deficiency anemia and its treatment - reply. (23049306)
2011
28
An interesting case of iron deficiency anemia. (20620279)
2010
29
Asymptomatic malaria in the etiology of iron deficiency anemia: a nutritionist's viewpoint. (21068349)
2010
30
Diagnosis and management of iron deficiency anemia in patients with IBD. (20924367)
2010
31
Leukocyte DNA damage in children with iron deficiency anemia: effect of iron supplementation. (20169450)
2010
32
The effects of iron deficiency anemia on p wave duration and dispersion. (21243273)
2010
33
Soluble transferrin receptor-ferritin index and estimated body iron in iron-deficiency anemia in "select" chronic diseases. (19137299)
2009
34
Profound iron deficiency anemia caused by a small-intestinal cavernous hemangioma. (19481664)
2009
35
Red blood cell flags for the differential diagnosis between thalassemia trait and iron deficiency anemia. (19843389)
2009
36
Appropriateness of colonoscopy in Europe (EPAGE II). Iron-deficiency anemia and hematochezia. (19280534)
2009
37
Education and improved iron intakes for treatment of mild iron-deficiency anemia in adolescent girls in southern Benin. (19445257)
2009
38
Tumor necrosis factor SNP haplotypes are associated with iron deficiency anemia in West African children. (18716131)
2008
39
Pencil cells and prekeratocytes in iron deficiency anemia. (18932191)
2008
40
Discrimination indices have no predictive value in differential diagnosis of iron deficiency anemia and beta-thalassemia trait. (18371062)
2008
41
Red cell distribution width in iron deficiency anemia and beta-thalassemia minor. (18697290)
2008
42
Prevalence of iron deficiency anemia in chronic diarrhoea and celiac disease - a western UP experience. (23100934)
2008
43
Increased plasma malondialdehyde and fructosamine in iron deficiency anemia: effect of treatment. (17698317)
2007
44
Treatment of iron deficiency anemia in orthopedic surgery with intravenous iron: efficacy and limits: a prospective study. (18043060)
2007
45
Prevalence of iron deficiency and iron deficiency anemia among three populations of female military personnel in the US Army. (16522934)
2006
46
Iron deficiency anemia with marked thrombocytosis complicated by central retinal vein occlusion. (16293924)
2005
47
Soluble transferrin receptor and immature reticulocytes are not useful for distinguishing iron-deficiency anemia from heterozygous beta-thalassemia. (12870058)
2003
48
Thrombocytosis in children with iron deficiency anemia: series of 42 children. (12368707)
2002
49
Treatment of iron deficiency anemia and associated protein-losing enteropathy in children. (10695822)
2000
50
Immunohistochemistry of the Hfe protein in patients with hereditary hemochromatosis, iron deficiency anemia, and normal controls. (10772870)
2000

Variations for Iron Deficiency Anemia

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Expression for genes affiliated with Iron Deficiency Anemia

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Search GEO for disease gene expression data for Iron Deficiency Anemia.

Pathways for genes affiliated with Iron Deficiency Anemia

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Compounds for genes affiliated with Iron Deficiency Anemia

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Compounds related to Iron Deficiency Anemia according to GeneCards Suite gene sharing:

(show top 50)    (show all 74)
idCompoundScoreTop Affiliating Genes
1anagrelide43 1210.9THPO, EPO
2pixy321439.9EPO, THPO
3amifostine43 1210.8EPO, THPO
4filgrastim43 1210.8EPO, THPO
5pyronin y439.7THPO, TFRC
6benzidine439.7EPO, TFRC
7cobalt chloride439.7TFRC, EPO
8ferric gluconate439.6TF, EPO
9recormon439.6TF, EPO
10iron sucrose439.6EPO, TF
11nandrolone decanoate43 1210.6TF, EPO
12fenton439.5EPO, TF
13gm-csf43 2810.5THPO, EPO
14triamcinolone acetonide43 2810.5EPO, TF
15aluminium citrate439.5TF, TFRC
16gallium439.4TF, TFRC
17apotransferrin439.4TF, TFRC
18bismuth43 2410.4TF, TFRC
19ferric ammonium citrate439.4TFRC, TF
20methylcellulose439.3TFRC, THPO, EPO
21fe3+439.3TFRC, TF
22hydroxyurea43 49 1211.3TFRC, EPO, THPO
23cytarabine43 49 1211.3EPO, THPO, TFRC
24tbps43 2810.3TFRC, TF
25nh4cl439.2TF, TFRC
26butyrate439.1EPO, THPO, TFRC
27fe2+439.1TFRC, TF
28rapamycin439.1THPO, TFRC, EPO
29ifosfamide43 1210.0THPO, TF
30deferiprone439.0TF, EPO, TFRC
31aluminium43 1210.0TF, EPO, TFRC
32iron dextran43 1210.0EPO, TFRC, TF
33succinylacetone439.0TF, EPO, TFRC
34zinc protoporphyrin439.0TFRC, TF, EPO
35protoporphyrin ix43 24 1211.0EPO, TFRC, TF
36deferoxamine43 1210.0TF, TFRC, EPO
37vitamin b12439.0TF, TFRC, EPO
38ly294002439.0TFRC, EPO, THPO
39folate438.9TF, TFRC, EPO
40polyethylene glycol438.9THPO, TFRC, TF
41ascorbic acid43 249.9TF, TFRC, EPO
42polysaccharide438.8TF, TFRC, THPO
43bafilomycin a143 59 1210.7TFRC, TF
44histamine43 28 2410.7THPO, TFRC, TF
45cyclosporin a43 28 5910.6TF, TFRC, EPO
46sialic acid438.5EPO, TF, TFRC, THPO
47lactate438.5EPO, THPO, TF, TFRC
48creatinine438.4THPO, TFRC, TF, EPO
49vegf438.4TFRC, EPO, THPO, TF
50iron43 248.6EPO, TF, TFRC, THPO, TMPRSS6, HFE2

GO Terms for genes affiliated with Iron Deficiency Anemia

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Cellular components related to Iron Deficiency Anemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:00725629.0TFRC, TF
2coated pitGO:00059058.9TF, TFRC
3cytoplasmic membrane-bounded vesicleGO:00160238.7TFRC, TF
4cell surfaceGO:00099868.1TF, TFRC, EPO, HFE2
5extracellular spaceGO:00056157.6HFE2, EPO, THPO, TFRC, TF

Biological processes related to Iron Deficiency Anemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1iron ion homeostasisGO:00550729.4HFE2, TMPRSS6
2cellular iron ion homeostasisGO:00068799.0TFRC, TF
3transferrin transportGO:00335728.7TFRC, TF

Molecular functions related to Iron Deficiency Anemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00051799.5EPO, THPO

Products for genes affiliated with Iron Deficiency Anemia

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Sources for Iron Deficiency Anemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet