MCID: IRN001
MIFTS: 57

Iron Deficiency Anemia malady

Immune diseases, Blood diseases, Metabolic diseases categories
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Summaries for Iron Deficiency Anemia

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Wikipedia:65 Iron-deficiency anemia (or iron-deficiency anaemia) is a common anemia (low red blood cell or hemoglobin... more...

MalaCards based summary: Iron Deficiency Anemia is related to iron-refractory iron deficiency anemia and thrombocytosis. An important gene associated with Iron Deficiency Anemia is TMPRSS6 (transmembrane protease, serine 6), and among its related pathways are Iron metabolism in placenta and Insulin receptor recycling. The drugs iron-dextran complex and ferric oxide and the compounds anagrelide and pixy321 have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and small intestine, and related mouse phenotypes are liver/biliary system and cardiovascular system.

Aliases & Classifications for Iron Deficiency Anemia

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Sources:
8Disease Ontology, 44Novoseek, 62UMLS, 27ICD9CM, 57SNOMED-CT, 34MeSH, 25ICD10
See all sources

Iron Deficiency Anemia, Aliases & Descriptions:

Name: Iron Deficiency Anemia 8 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Metabolic diseases
Anatomical: Immune diseases, Blood diseases


External Ids:

Disease Ontology8 DOID:11758
ICD9CM27 280.8
MeSH34 D018798
ICD1025 D50

Related Diseases for Iron Deficiency Anemia

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Diseases related to Iron Deficiency Anemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 154)
idRelated DiseaseScoreTop Affiliating Genes
1iron-refractory iron deficiency anemia32.1TMPRSS6
2thrombocytosis31.3EPO, THPO
3deficiency anemia31.1TFRC, TF, EPO, HFE2, THPO, TMPRSS6
4beta thalassemia31.1TFRC, TF
5hemosiderosis31.0TF, EPO
6pancytopenia30.7THPO, EPO
7iron metabolism disease30.5HFE2, TF
8hypogonadism30.5TF
9thrombocytopenia30.5EPO, THPO
10splenomegaly30.5EPO, THPO
11restless legs syndrome30.5TF, TFRC
12microcytic anemia30.2EPO, TFRC, TF
13hemoglobinopathy30.2EPO, TFRC, TF
14sickle cell disease30.2EPO, TFRC, TF
15hemolytic anemia30.2EPO, TF, TFRC
16refractory anemia30.2EPO, THPO, TFRC
17hemochromatosis30.1HFE2, TFRC, TF
18thalassemia10.9
19inflammatory bowel disease10.7
20celiac disease10.6
21gastritis10.6
22cerebritis10.6
23kidney disease10.6
24hemangioma10.5
25retinitis10.5
26cavernous hemangioma10.4
27papilledema10.4
28arteriovenous fistula10.4EPO
29aceruloplasminemia10.4HFE2
30hypersplenism10.4THPO
31arthritis10.4
32malaria10.4
33rheumatoid arthritis10.4
34atrophic gastritis10.4
35giardiasis10.4
36duodenitis10.4
37adenoma10.4
38blue rubber bleb nevus syndrome10.4
39febrile seizures10.4
40cerebral sinovenous thrombosis10.4
41hereditary hemorrhagic telangiectasia10.3
42hypertension10.3
43obesity10.3
44retinal vein occlusion10.3
45central retinal vein occlusion10.3
46gastric antral vascular ectasia10.3
47protein-losing enteropathy10.3
48intussusception10.3
49gastroduodenitis10.3
50congenital diaphragmatic hernia10.3

Graphical network of the top 20 diseases related to Iron Deficiency Anemia:



Diseases related to iron deficiency anemia

Symptoms for Iron Deficiency Anemia

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Drugs & Therapeutics for Iron Deficiency Anemia

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Genetic Tests for Iron Deficiency Anemia

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Anatomical Context for Iron Deficiency Anemia

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MalaCards organs/tissues related to Iron Deficiency Anemia:

32
Heart, Kidney, Small intestine, Colon, Testes, Bone, Bone marrow, Placenta, Neutrophil, Eye, Brain, Lung, Thyroid, Breast

Animal Models for Iron Deficiency Anemia or affiliated genes

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MGI Mouse Phenotypes related to Iron Deficiency Anemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.5TFRC, HFE2, EPO, TMPRSS6
2MP:00053858.5EPO, TMPRSS6, TFRC, HFE2
3MP:00107718.4TFRC, TMPRSS6, EPO, HFE2
4MP:00053767.6HFE2, EPO, TMPRSS6, TFRC, TF
5MP:00107687.3EPO, TMPRSS6, TFRC, TF, HFE2
6MP:00053977.2EPO, HFE2, TMPRSS6, TF, TFRC, THPO

Publications for Iron Deficiency Anemia

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Articles related to Iron Deficiency Anemia:

(show top 50)    (show all 619)
idTitleAuthorsYear
1
The relationship between iron deficiency anemia and simple febrile convulsion in children. (25250062)
2014
2
Treatment of iron-deficiency anemia in patients with subclinical hypothyroidism. (23582934)
2013
3
Prevalence and predictive factors for gastrointestinal pathology in young men evaluated for iron deficiency anemia. (23192647)
2013
4
Effect of sequential versus standard Helicobacter pylori eradication therapy on the associated iron deficiency anemia in children. (24130381)
2013
5
Iron deficiency anemia in patients with inflammatory bowel disease. (23766655)
2013
6
Intravenous iron sucrose versus oral iron in treatment of iron deficiency anemia in pregnancy: a randomized clinical trial. (22925176)
2013
7
Iron deficiency anemia in infants: does it really affect the myocardial functions? (23387876)
2013
8
Rapid Assessment for Coexistence of Vitamin B12 and Iron Deficiency Anemia among Adolescent Males and Females in Northern Himalayan State of India. (23970962)
2013
9
Effect of iron deficiency anemia in pregnancy on child mental development in rural China. (23400604)
2013
10
Intravenous iron monotherapy for the treatment of non-iron-deficiency anemia in cancer patients undergoing chemotherapy: a pilot study. (24039403)
2013
11
Human serum transferrin: is there a link among autism, high oxalate levels, and iron deficiency anemia? (24152109)
2013
12
Refractory Iron-deficiency Anemia and Autoimmune Atrophic Gastritis in Pediatric Age Group: Analysis of 8 Clinical Cases. (24327126)
2013
13
Combined cobalamin and iron deficiency anemia: a diagnostic approach using a model based on age and homocysteine assessment. (23183879)
2013
14
Comment on: Hardikar et al. Spuriously high prevalence of prediabetes diagnosed by HbA(1c) in young indians partly explained by hematological factors and iron deficiency anemia. Diabetes Care 2012;35:797a89802. (23349156)
2013
15
Ferric carboxymaltose for the treatment of iron-deficiency anemia. [corrected]. (22413903)
2012
16
Efficacy of Trikatrayadi Lauha in Panduroga with reference to Iron Deficiency Anemia. (23049186)
2012
17
Dietary counseling for preventing iron deficiency anemia in infants in Brazil: something more is needed. (22344409)
2012
18
Effects of iron deficiency anemia and its treatment with iron polymaltose complex in pregnant rats, their fetuses and placentas: oxidative stress markers and pregnancy outcome. (22153683)
2012
19
Diagnostic yield of small-bowel capsule endoscopy in patients with iron-deficiency anemia: a systematic review. (23078923)
2012
20
Artificial intelligence models for predicting iron deficiency anemia and iron serum level based on accessible laboratory data. (21503744)
2012
21
Iron deficiency and iron-deficiency anemia in the first two years of life: strategies to prevent loss of developmental potential. (22043885)
2011
22
An unusual cause of iron deficiency anemia and abdominal pain in a young female. (21396329)
2011
23
Hereditary hyperferritinemia-cataract syndrome (HHCS) presenting with iron deficiency anemia associated with a new mutation in the iron responsive element of the L ferritin gene in a Swiss family. (21410535)
2011
24
A prospective evaluation of iron deficiency anemia in the GI endoscopy setting: role of standard endoscopy, videocapsule endoscopy, and CT-enteroclysis. (21396638)
2011
25
Iron deficiency anemia and its treatment - reply. (23049306)
2011
26
An interesting case of iron deficiency anemia. (20620279)
2010
27
Asymptomatic malaria in the etiology of iron deficiency anemia: a nutritionist's viewpoint. (21068349)
2010
28
Diagnosis and management of iron deficiency anemia in patients with IBD. (20924367)
2010
29
Leukocyte DNA damage in children with iron deficiency anemia: effect of iron supplementation. (20169450)
2010
30
The effects of iron deficiency anemia on p wave duration and dispersion. (21243273)
2010
31
Identification of clinical and simple laboratory variables predicting responsible gastrointestinal lesions in patients with iron deficiency anemia. (21209799)
2010
32
Soluble transferrin receptor-ferritin index and estimated body iron in iron-deficiency anemia in "select" chronic diseases. (19137299)
2009
33
Profound iron deficiency anemia caused by a small-intestinal cavernous hemangioma. (19481664)
2009
34
Red blood cell flags for the differential diagnosis between thalassemia trait and iron deficiency anemia. (19843389)
2009
35
Appropriateness of colonoscopy in Europe (EPAGE II). Iron-deficiency anemia and hematochezia. (19280534)
2009
36
Education and improved iron intakes for treatment of mild iron-deficiency anemia in adolescent girls in southern Benin. (19445257)
2009
37
Tumor necrosis factor SNP haplotypes are associated with iron deficiency anemia in West African children. (18716131)
2008
38
Pencil cells and prekeratocytes in iron deficiency anemia. (18932191)
2008
39
Discrimination indices have no predictive value in differential diagnosis of iron deficiency anemia and beta-thalassemia trait. (18371062)
2008
40
Red cell distribution width in iron deficiency anemia and beta-thalassemia minor. (18697290)
2008
41
Prevalence of iron deficiency anemia in chronic diarrhoea and celiac disease - a western UP experience. (23100934)
2008
42
Increased plasma malondialdehyde and fructosamine in iron deficiency anemia: effect of treatment. (17698317)
2007
43
Treatment of iron deficiency anemia in orthopedic surgery with intravenous iron: efficacy and limits: a prospective study. (18043060)
2007
44
Iron deficiency anemia following prenatal nutrition interventions. (18073006)
2007
45
Iron deficiency anemia with marked thrombocytosis complicated by central retinal vein occlusion. (16293924)
2005
46
Soluble transferrin receptor and immature reticulocytes are not useful for distinguishing iron-deficiency anemia from heterozygous beta-thalassemia. (12870058)
2003
47
Thrombocytosis in children with iron deficiency anemia: series of 42 children. (12368707)
2002
48
Treatment of iron deficiency anemia and associated protein-losing enteropathy in children. (10695822)
2000
49
Immunohistochemistry of the Hfe protein in patients with hereditary hemochromatosis, iron deficiency anemia, and normal controls. (10772870)
2000
50
Plasma erythropoietic activity in healthy children and in children with iron-deficiency anemia]. (8054570)
1993

Variations for Iron Deficiency Anemia

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Expression for genes affiliated with Iron Deficiency Anemia

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Expression patterns in normal tissues for genes affiliated with Iron Deficiency Anemia

Search GEO for disease gene expression data for Iron Deficiency Anemia.

Pathways for genes affiliated with Iron Deficiency Anemia

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Compounds for genes affiliated with Iron Deficiency Anemia

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Compounds related to Iron Deficiency Anemia according to GeneCards/GeneDecks:

(show top 50)    (show all 74)
idCompoundScoreTop Affiliating Genes
1anagrelide44 1110.9THPO, EPO
2pixy321449.9EPO, THPO
3amifostine44 1110.8EPO, THPO
4filgrastim44 1110.8EPO, THPO
5pyronin y449.7THPO, TFRC
6benzidine449.7EPO, TFRC
7cobalt chloride449.7TFRC, EPO
8ferric gluconate449.6TF, EPO
9recormon449.6TF, EPO
10iron sucrose449.6EPO, TF
11nandrolone decanoate44 1110.6TF, EPO
12fenton449.5EPO, TF
13gm-csf44 2810.5THPO, EPO
14triamcinolone acetonide44 2810.5EPO, TF
15aluminium citrate449.5TF, TFRC
16gallium449.4TF, TFRC
17apotransferrin449.4TF, TFRC
18bismuth44 2410.4TF, TFRC
19ferric ammonium citrate449.4TFRC, TF
20methylcellulose449.3TFRC, THPO, EPO
21fe3+449.3TFRC, TF
22hydroxyurea44 50 1111.3TFRC, EPO, THPO
23cytarabine44 50 1111.3EPO, THPO, TFRC
24tbps44 2810.3TFRC, TF
25nh4cl449.2TF, TFRC
26butyrate449.1EPO, THPO, TFRC
27fe2+449.1TFRC, TF
28rapamycin449.1THPO, TFRC, EPO
29ifosfamide44 1110.0THPO, TF
30deferiprone449.0TF, EPO, TFRC
31aluminium44 1110.0TF, EPO, TFRC
32iron dextran44 1110.0EPO, TFRC, TF
33succinylacetone449.0TF, EPO, TFRC
34zinc protoporphyrin449.0TFRC, TF, EPO
35protoporphyrin ix44 24 1111.0EPO, TFRC, TF
36deferoxamine44 1110.0TF, TFRC, EPO
37vitamin b12449.0TF, TFRC, EPO
38ly294002449.0TFRC, EPO, THPO
39folate448.9TF, TFRC, EPO
40polyethylene glycol448.9THPO, TFRC, TF
41ascorbic acid44 249.9TF, TFRC, EPO
42polysaccharide448.8TF, TFRC, THPO
43bafilomycin a144 61 1110.7TFRC, TF
44histamine44 28 2410.7THPO, TFRC, TF
45cyclosporin a44 28 6110.6TF, TFRC, EPO
46sialic acid448.5EPO, TF, TFRC, THPO
47lactate448.5EPO, THPO, TF, TFRC
48creatinine448.4THPO, TFRC, TF, EPO
49vegf448.4TFRC, EPO, THPO, TF
50iron44 248.6EPO, TF, TFRC, THPO, TMPRSS6, HFE2

GO Terms for genes affiliated with Iron Deficiency Anemia

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Cellular components related to Iron Deficiency Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:0725629.0TFRC, TF
2coated pitGO:0059058.9TF, TFRC
3cytoplasmic membrane-bounded vesicleGO:0160238.7TFRC, TF
4cell surfaceGO:0099868.1TF, TFRC, EPO, HFE2
5extracellular spaceGO:0056157.6HFE2, EPO, THPO, TFRC, TF

Biological processes related to Iron Deficiency Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1iron ion homeostasisGO:0550729.4HFE2, TMPRSS6
2cellular iron ion homeostasisGO:0068799.0TFRC, TF
3transferrin transportGO:0335728.7TFRC, TF

Molecular functions related to Iron Deficiency Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.5EPO, THPO

Products for genes affiliated with Iron Deficiency Anemia

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  • Antibodies
  • Proteins
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Sources for Iron Deficiency Anemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet