MCID: IRN001
MIFTS: 61

Iron Deficiency Anemia malady

Immune diseases, Blood diseases categories

Summaries for Iron Deficiency Anemia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Iron-deficiency anemia (or iron-deficiency anaemia) is a common anemia (low red blood cell or hemoglobin... more...

MalaCards: Iron Deficiency Anemia is related to deficiency anemia and iron-refractory iron deficiency anemia. An important gene associated with Iron Deficiency Anemia is TMPRSS6 (transmembrane protease, serine 6), and among its related pathways are HIF-1 signaling pathway and Zinc transporters. The drugs iron-dextran complex and ferric oxide and the compounds fenton and deferiprone have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and testes, and related mouse phenotypes are integument and growth/size.

Aliases & Classifications for Iron Deficiency Anemia

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8Disease Ontology, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases, Blood diseases


Aliases & Descriptions:

iron deficiency anemia 8 44 60


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Disease Ontology8 DOID:11758
MeSH34 D018798
ICD9CM27 280.8
ICD1025 D50

Related Diseases for Iron Deficiency Anemia

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17GeneCards, 18GeneDecks
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Diseases related to Iron Deficiency Anemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 202)
idRelated DiseaseScoreTop Affiliating Genes
1deficiency anemia32.2TMPRSS6, FECH, HEPH, IREB2, HAMP, G6PD
2iron-refractory iron deficiency anemia31.0TMPRSS6
3beta thalassemia30.9HFE, TFRC, TF
4thrombocytosis30.9EPO, IL11, THPO
5celiac disease30.8TFRC, HFE
6hemosiderosis30.7TF, HFE, EPO
7microcytic anemia30.6SLC11A2, EPO, TFRC, TF, G6PD
8iron metabolism disease30.5HFE
9malaria30.5G6PD, TFRC
10arthritis30.5LTF, HFE, TFR2
11sickle cell disease30.5HBG2, EPO, TFRC, TF, G6PD
12hemolytic anemia30.5G6PD, TF, TFRC, HFE, EPO, HBG2
13thrombocytopenia30.5HFE, EPO, IL11, THPO
14rheumatoid arthritis30.5THPO, IL11, LTF, HFE, TFRC
15restless legs syndrome30.3TFRC, TF
16obesity30.3HFE, TFRC
17hypochromic microcytic anemia30.3SLC11A2, TF
18folic acid deficiency anemia30.3TFRC, EPO
19hemoglobinopathy30.3G6PD, TF, TFRC, HFE, EPO
20hemochromatosis30.3HAMP, HEPH, TF, TFR2, TMPRSS6, ACO1
21cataract30.1G6PD
22adenocarcinoma30.1FECH
23purpura30.1THPO
24hypogonadism30.1HFE, TF
25congenital hemolytic anemia30.1G6PD, TF
26chronic kidney failure30.1THPO, EPO, LTF, TF
27alzheimer's disease30.1IREB2, HFE, IL11, SLC11A2
28diabetes mellitus30.1G6PD, TF, HFE
29thalassemia10.8
30inflammatory bowel disease10.6
31cerebritis10.5
32gastritis10.5
33kidney disease10.5
34hemangioma10.5
35retinitis10.4
36cavernous hemangioma10.4
37papilledema10.4
38stroke, ischemic10.3
39atrophic gastritis10.3
40sickle cell anemia10.3
41giardiasis10.3
42hypochromic anemia10.3
43duodenitis10.3
44adenoma10.3
45hereditary hemorrhagic telangiectasia10.2
46pancytopenia10.2
47gastric antral vascular ectasia10.2
48central retinal vein occlusion10.2
49intussusception10.2
50protein-losing enteropathy10.2

Graphical network of the top 20 diseases related to Iron Deficiency Anemia:



Diseases related to iron deficiency anemia

Clinical Features for Iron Deficiency Anemia

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Drugs & Therapeutics for Iron Deficiency Anemia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Iron Deficiency Anemia

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Anatomical Context for Iron Deficiency Anemia

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32MalaCards
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MalaCards organs/tissues related to Iron Deficiency Anemia:

32
Kidney, Heart, Testes, Colon, Small intestine, Bone, Bone marrow, Placenta, Brain, Eye, Liver, Lung, Thyroid, Breast

Animal Models for Iron Deficiency Anemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Iron Deficiency Anemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107719.5HEPH, FECH, HFE2, SLC11A2, TMPRSS6
2MP:00053789.2HAMP, G6PD, TF, TFR2, TFRC, HFE
3MP:00053709.0HEPH, FECH, IREB2, TFR2, TFRC, HFE
4MP:00053878.7HEPH, FECH, IREB2, HAMP, TFR2, TFRC
5MP:00107688.7TF, G6PD, HAMP, IREB2, FECH, TFRC
6MP:00053978.5TMPRSS6, HEPH, FECH, IREB2, HAMP, G6PD
7MP:00053768.4TFR2, TF, G6PD, HAMP, IREB2, FECH

Publications for Iron Deficiency Anemia

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50PubMed
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Articles related to Iron Deficiency Anemia:

(show top 50)    (show all 670)
idTitleAuthorsYear
1
Effect of sequential versus standard Helicobacter pylori eradication therapy on the associated iron deficiency anemia in children. (24130381)
2013
2
Effect of iron deficiency anemia in pregnancy on child mental development in rural China. (23400604)
2013
3
Combined cobalamin and iron deficiency anemia: a diagnostic approach using a model based on age and homocysteine assessment. (23183879)
2013
4
Comment on: Hardikar et al. Spuriously high prevalence of prediabetes diagnosed by HbA(1c) in young indians partly explained by hematological factors and iron deficiency anemia. Diabetes Care 2012;35:797a89802. (23349156)
2013
5
Isolated lateral sinus thrombosis presenting as cerebellar infarction in a patient with iron deficiency anemia. (24044081)
2013
6
Cerebral venous sinus thrombosis in a child with iron-deficiency anemia. (23553265)
2013
7
Treatment of iron deficiency anemia in children: a comparative study of ferrous ascorbate and colloidal iron. (23180405)
2013
8
Intravenous ferric carboxymaltose versus standard medical care in the treatment of iron deficiency anemia in patients with chronic kidney disease: a randomized, active-controlled, multi-center study. (23222534)
2013
9
Association between Ischemic Stroke and Iron-Deficiency Anemia: A Population-Based Study. (24349404)
2013
10
Cryptogenia multifocal ulcerous stenosing enteritis: An entity on its own as a cause of abdominal pain, iron deficiency anemia and protein-losing enteropathy. (24035666)
2013
11
Anemia and iron deficiency in inflammatory bowel disease: an open, prospective, observational study on diagnosis, treatment with ferric carboxymaltose and quality of life. (23889159)
2013
12
Effects of iron deficiency anemia and its treatment with iron polymaltose complex in pregnant rats, their fetuses and placentas: oxidative stress markers and pregnancy outcome. (22153683)
2012
13
Solitary cavernous hemangioma of the small intestine as the cause of long-standing iron deficiency anemia. (22875598)
2012
14
Glutathionyl hemoglobin is elevated in iron deficiency anemia. (21996674)
2012
15
Physicochemical properties and inhibition effect on iron deficiency anemia of a novel polysaccharide-iron complex (LPPC). (22153938)
2012
16
Clinical case of the month. Idiopathic pulmonary hemosiderosis presenting as a rare cause of iron deficiency anemia in a toddler--a diagnostic challenge. (23362597)
2012
17
Iron deficiency anemia: pregnancy outcomes with or without iron supplementation. (20381313)
2011
18
Efficacy and safety of intravenous iron sucrose in treating adults with iron deficiency anemia. (23049360)
2011
19
Normal hemoglobin at the age of 1 year does not protect infants from developing iron deficiency anemia in the second year of life. (21792044)
2011
20
Responses of HSC70 expression in diencephalon to iron deficiency anemia in rats. (21811788)
2011
21
Iron-deficiency anemia associated with hiatal hernia: case reports and literature review. (20837629)
2010
22
Diagnosis of iron deficiency anemia in children of Northeast Brazil. (20549021)
2010
23
Iron deficiency anemia and cognitive function in infancy. (20660551)
2010
24
Iron-deficiency anemia secondary to mutations in genes controlling hepcidin. (21083463)
2010
25
Polymorphisms and mutations of human TMPRSS6 in iron deficiency anemia. (19818657)
2010
26
Profound iron deficiency anemia caused by a small-intestinal cavernous hemangioma. (19481664)
2009
27
Atrophy of the intestinal villi in a post-gastrectomy patient with severe iron deficiency anemia. (19893874)
2009
28
Iron deficiency anemia: diagnosis and management. (19262200)
2009
29
Evaluation of iron deficiency anemia in older adults: the role of wireless capsule endoscopy. (19623687)
2009
30
A history of iron deficiency anemia during infancy alters brain monoamine activity later in juvenile monkeys. (19194962)
2009
31
Adaptive response of the heart to long-term anemia induced by iron deficiency. (19136608)
2009
32
Clinical challenges and images in GI. Ampullary somatostatinoma associated with neurofibromatosis type 1, presenting with iron-deficiency anemia. (19063889)
2009
33
Tumor necrosis factor SNP haplotypes are associated with iron deficiency anemia in West African children. (18716131)
2008
34
Discrimination indices have no predictive value in differential diagnosis of iron deficiency anemia and beta-thalassemia trait. (18371062)
2008
35
Occurrence and detection of iron-deficiency anemia in infants and toddlers. (19174983)
2008
36
Is Blastocystis hominis a new etiologic factor or a coincidence in iron deficiency anemia? (18397391)
2008
37
Serum transferrin receptor-ferritin index shows concomitant iron deficiency anemia and anemia of chronic disease is common in patients with rheumatoid arthritis in north India. (18417876)
2008
38
The relationship between iron deficiency anemia and lipid metabolism in premenopausal women. (18004086)
2007
39
Iron deficiency anemia in Asians and Caucasians -- Any differences? (18431017)
2007
40
Food fortification strategy--preventing iron deficiency anemia: a review. (17453923)
2007
41
Effect of Angelica sinensis polysaccharide-iron complex on iron deficiency anemia in rats. (18180896)
2007
42
Giant hepatocellular adenoma presenting with chronic iron deficiency anemia. (16817847)
2006
43
Distribution of anemia associated with micronutrient deficiencies other than iron in a probabilistic sample of Mexican children. (17191024)
2006
44
Neutrophil hypersegmentation and thrombocytosis in children with iron deficiency anemia. (16250310)
2005
45
Hereditary spherocytosis veiled by anemia and iron deficiency. (16122152)
2005
46
Thrombocytosis in iron deficiency anemia. (16293910)
2005
47
Soluble transferrin receptor and transferrin receptor-ferritin index in iron deficiency anemia and anemia in rheumatoid arthritis. (15843240)
2005
48
Superoxide dismutase and glutathione peroxidase in erythrocytes of patients with iron deficiency anemia: effects of different treatment modalities. (11828552)
2002
49
Quantitative determinations of microcytic-hypochromic red blood cell population and glycerol permeability in iron-deficiency anemia and beta thalassemia minor. (10550558)
1999
50
Decreased erythropoietin responsiveness to iron deficiency anemia in the elderly. (8352231)
1993

Genetic Variations for Iron Deficiency Anemia

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Expression for genes affiliated with Iron Deficiency Anemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Iron Deficiency Anemia

Search GEO for disease gene expression data for Iron Deficiency Anemia.

Pathways for genes affiliated with Iron Deficiency Anemia

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29KEGG, 53Reactome, 37NCBI BioSystems Database
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Compounds for genes affiliated with Iron Deficiency Anemia

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44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB
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Compounds related to Iron Deficiency Anemia according to GeneCards/GeneDecks:

(show top 50)    (show all 110)
idCompoundScoreTop Affiliating Genes
1fenton4410.7HBG2
2deferiprone4410.6TFRC, TF, EPO
3aluminium44 1111.6EPO, TFRC, TF
4iron dextran44 1111.5TFRC, EPO, TF
5bismuth44 2411.5TF, LTF, TFRC
6apotransferrin4410.5TF, LTF, TFRC
723-diphosphoglycerate4410.5G6PD, HBG2, EPO
8protoporphyrin ix44 11 2412.4TF, FECH, TFRC, EPO
9recormon4410.4EPO, TF
10pixy3214410.4THPO, IL11, EPO
11succinylacetone4410.4EPO, TF, IREB2, TFRC
12amifostine44 1111.4EPO, IL11, THPO
13filgrastim44 1111.4EPO, THPO, IL11
14zinc protoporphyrin4410.4TFRC, TF, G6PD, EPO, FECH
15fecl34410.3LTF, TF
16methylcellulose4410.3EPO, TFRC, THPO, IL11
17aluminium citrate4410.3TFRC, TF
18copper44 2411.3SLC11A2, HEPH, SLC40A1, FECH
19ribavirin44 49 1112.3TF, G6PD, LTF, EPO
20vitamin b124410.3LTF, G6PD, TF, TFRC, EPO
21haem4410.3HFE, SLC11A2, FECH
22hydroxyurea44 49 1112.3TFRC, HBG2, THPO, EPO
23sialic acid4410.3EPO, THPO, LTF, TFRC, TF
24ferric gluconate4410.3TF, EPO
25ferric ammonium citrate4410.2IREB2, TFRC, ACO1, LTF, TF
26n-ethylmaleimide44 1111.2IREB2, G6PD, TFRC, ACO1, HBG2
27polyethylene glycol4410.2G6PD, TFRC, HBG2, IL11, TF, THPO
28cytarabine44 49 1112.2IL11, TFRC, EPO, THPO
29azathioprine44 49 2 1113.2LTF, IL11, G6PD, EPO
308-aminoquinoline4410.1G6PD, HBG2
31tocopherol4410.1TF, HBG2, G6PD
32oxygen44 2411.1IL11, HAMP, IREB2, EPO, ACO1
33lactate4410.1G6PD, EPO, TFRC, TF, THPO, HBG2
34sodium nitroprusside4410.1G6PD, TF, TFRC, ACO1, HBG2, IREB2
355-aminolevulinic acid44 2411.1ACO1, SLC11A2, HFE, TFRC, IREB2, FECH
36epinephrine44 11 2412.1G6PD, HBG2, THPO, TF, IL11
37aspartate4410.0TF, G6PD, IL11, TFRC, HFE, LTF
38ascorbic acid44 2411.0HBG2, EPO, TFRC, LTF, G6PD, SLC11A2
39citrate4410.0ACO1, SLC11A2, IREB2, LTF, TFRC, TF
40superoxide44 2411.0FECH, ACO1, THPO, HBG2, LTF, G6PD
41creatinine4410.0G6PD, TF, TFRC, LTF, HBG2, THPO
42h2o2449.9G6PD, HBG2, THPO, IREB2, LTF, ACO1
43cis-aconitate449.9LTF, ACO1
44fe3+449.9TFRC, FECH, IREB2, TF, ACO1, SLC11A2
45n acetylcysteine449.9TFRC, ACO1, IREB2, HBG2, G6PD, TF
46alanine449.8TF, HBG2, THPO, LTF, IL11, FECH
47fe2+449.8SLC40A1, SLC11A2, ACO1, HBG2, LTF, HFE
48cysteine449.6TFRC, ACO1, LTF, FECH, IL11, IREB2
49deferoxamine44 1110.6IREB2, ACO1, EPO, HBG2, LTF, TFRC
50iron44 249.5IL11, FECH, HEPH, IREB2, HAMP, TF

GO Terms for genes affiliated with Iron Deficiency Anemia

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16Gene Ontology
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Cellular components related to Iron Deficiency Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basal part of cellGO:04517810.2SLC11A2, HFE, TF
2recycling endosomeGO:05503710.1TF, HFE, SLC11A2
3perinuclear region of cytoplasmGO:0484719.8SLC11A2, HFE, TFRC, TF, HEPH
4integral to plasma membraneGO:0058879.7TFRC, TMPRSS11A, SLC40A1, SLC11A2, HFE, TFR2
5extracellular regionGO:0055769.3TMPRSS11A, TF, IL11, EPO, LTF, TFRC

Biological processes related to Iron Deficiency Anemia according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1multicellular organismal iron ion homeostasisGO:06058610.3SLC40A1, SLC11A2, HFE
2iron ion homeostasisGO:05507210.3FECH, HFE2, TMPRSS6
3response to iron(II) ionGO:01004010.2ACO1, IREB2
4copper ion transportGO:00682510.2SLC11A2, HEPH
5iron ion transportGO:00682610.0HEPH, IREB2, TFR2, LTF
6intestinal absorptionGO:05089210.0ACO1, IREB2
7erythrocyte maturationGO:04324910.0EPO, G6PD
8proteolysisGO:0065089.9TFR2, TFRC, LTF, TMPRSS6, TMPRSS11A
9transmembrane transportGO:0550859.8HEPH, TF, TFRC, SLC11A2, SLC40A1
10cellular iron ion homeostasisGO:0068799.3ACO1, HEPH, IREB2, HAMP, TF, TFR2

Molecular functions related to Iron Deficiency Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ferric iron bindingGO:00819910.2LTF, TF
2transferrin receptor activityGO:00499810.2TFRC, TFR2
3iron-responsive element bindingGO:03035010.1ACO1, IREB2, FECH
4hormone activityGO:0051799.8THPO, EPO, HAMP
5protein bindingGO:0055158.7TFRC, TF, G6PD, IREB2, FECH, HFE

Products for genes affiliated with Iron Deficiency Anemia

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Sources for Iron Deficiency Anemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet