MCID: IRN001
MIFTS: 57

Iron Deficiency Anemia malady

Immune diseases, Blood diseases categories

Summaries for Iron Deficiency Anemia

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66Wikipedia, 34MalaCards
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Wikipedia:66 Iron-deficiency anemia (or iron-deficiency anaemia) is a common anemia (low red blood cell or hemoglobin... more...

MalaCards: Iron Deficiency Anemia is related to deficiency anemia and iron-refractory iron deficiency anemia. An important gene associated with Iron Deficiency Anemia is TMPRSS6 (transmembrane protease, serine 6), and among its related pathways are Iron metabolism in placenta and Insulin receptor recycling. The drugs iron-dextran complex and ferric oxide and the compounds anagrelide and pixy321 have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and small intestine, and related mouse phenotypes are liver/biliary system and cardiovascular system.

Aliases & Classifications for Iron Deficiency Anemia

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9Disease Ontology, 46Novoseek, 63UMLS, 59SNOMED-CT, 28ICD9CM, 36MeSH, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases, Blood diseases


Aliases & Descriptions:

iron deficiency anemia 9 46 63


External Ids:

Disease Ontology9 DOID:11758
ICD9CM28 280.8
MeSH36 D018798
ICD1026 D50

Related Diseases for Iron Deficiency Anemia

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Iron Deficiency Anemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 149)
idRelated DiseaseScoreTop Affiliating Genes
1deficiency anemia32.0TF, TFRC, THPO, TMPRSS6, EPO, HFE2
2iron-refractory iron deficiency anemia31.5TMPRSS6
3thrombocytosis31.1EPO, THPO
4beta thalassemia31.0TF, TFRC
5hemosiderosis30.9EPO, TF
6thrombocytopenia30.5EPO, THPO
7pancytopenia30.5EPO, THPO
8iron metabolism disease30.4HFE2, TF
9restless legs syndrome30.4TFRC, TF
10microcytic anemia30.4TF, TFRC, EPO
11hemoglobinopathy30.4EPO, TFRC, TF
12sickle cell disease30.4EPO, TFRC, TF
13hemolytic anemia30.4TF, TFRC, EPO
14hemochromatosis30.3TF, TFRC, HFE2
15hypogonadism30.3TF
16splenomegaly30.3EPO, THPO
17refractory anemia30.2EPO, THPO, TFRC
18thalassemia10.9
19inflammatory bowel disease10.7
20celiac disease10.6
21cerebritis10.6
22gastritis10.6
23kidney disease10.6
24hemangioma10.5
25retinitis10.5
26cavernous hemangioma10.4
27papilledema10.4
28atrophic gastritis10.4
29giardiasis10.4
30duodenitis10.4
31adenoma10.4
32arthritis10.4
33malaria10.4
34rheumatoid arthritis10.4
35febrile seizures10.4
36cerebral sinovenous thrombosis10.4
37hereditary hemorrhagic telangiectasia10.3
38central retinal vein occlusion10.3
39gastric antral vascular ectasia10.3
40protein-losing enteropathy10.3
41intussusception10.3
42gastroduodenitis10.3
43congenital diaphragmatic hernia10.3
44peutz-jeghers syndrome10.3
45amyloidosis10.3
46colon cancer10.3
47hypertension10.3
48lipoma10.3
49obesity10.3
50retinal vein occlusion10.3

Graphical network of the top 20 diseases related to Iron Deficiency Anemia:



Diseases related to iron deficiency anemia

Symptoms for Iron Deficiency Anemia

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Drugs & Therapeutics for Iron Deficiency Anemia

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Genetic Tests for Iron Deficiency Anemia

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Anatomical Context for Iron Deficiency Anemia

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34MalaCards
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MalaCards organs/tissues related to Iron Deficiency Anemia:

34
Kidney, Heart, Small intestine, Colon, Testes, Bone, Placenta, Bone marrow, Eye, Thyroid, Breast, Lung, Brain

Animal Models for Iron Deficiency Anemia or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Iron Deficiency Anemia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.5TFRC, TMPRSS6, EPO, HFE2
2MP:00053858.5HFE2, EPO, TMPRSS6, TFRC
3MP:00107718.4HFE2, EPO, TMPRSS6, TFRC
4MP:00053767.6TF, TFRC, TMPRSS6, EPO, HFE2
5MP:00107687.3TF, TFRC, TMPRSS6, EPO, HFE2
6MP:00053977.2HFE2, EPO, TMPRSS6, THPO, TFRC, TF

Publications for Iron Deficiency Anemia

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53PubMed
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Articles related to Iron Deficiency Anemia:

(show top 50)    (show all 594)
idTitleAuthorsYear
1
Treatment of iron-deficiency anemia in patients with subclinical hypothyroidism. (23582934)
2013
2
Prevalence and predictive factors for gastrointestinal pathology in young men evaluated for iron deficiency anemia. (23192647)
2013
3
Positive relationship between a polymorphism in Helicobacter pylori neutrophil-activating protein a gene and iron-deficiency anemia. (23067298)
2013
4
Effect of sequential versus standard Helicobacter pylori eradication therapy on the associated iron deficiency anemia in children. (24130381)
2013
5
Iron deficiency anemia in patients with inflammatory bowel disease. (23766655)
2013
6
Intravenous iron sucrose versus oral iron in treatment of iron deficiency anemia in pregnancy: a randomized clinical trial. (22925176)
2013
7
Iron deficiency anemia in infants: does it really affect the myocardial functions? (23387876)
2013
8
Rapid Assessment for Coexistence of Vitamin B12 and Iron Deficiency Anemia among Adolescent Males and Females in Northern Himalayan State of India. (23970962)
2013
9
Effect of iron deficiency anemia in pregnancy on child mental development in rural China. (23400604)
2013
10
Intravenous iron monotherapy for the treatment of non-iron-deficiency anemia in cancer patients undergoing chemotherapy: a pilot study. (24039403)
2013
11
Human serum transferrin: is there a link among autism, high oxalate levels, and iron deficiency anemia? (24152109)
2013
12
Refractory Iron-deficiency Anemia and Autoimmune Atrophic Gastritis in Pediatric Age Group: Analysis of 8 Clinical Cases. (24327126)
2013
13
Combined cobalamin and iron deficiency anemia: a diagnostic approach using a model based on age and homocysteine assessment. (23183879)
2013
14
Comment on: Hardikar et al. Spuriously high prevalence of prediabetes diagnosed by HbA(1c) in young indians partly explained by hematological factors and iron deficiency anemia. Diabetes Care 2012;35:797a89802. (23349156)
2013
15
Ferric carboxymaltose for the treatment of iron-deficiency anemia. [corrected]. (22413903)
2012
16
Efficacy of Trikatrayadi Lauha in Panduroga with reference to Iron Deficiency Anemia. (23049186)
2012
17
Dietary counseling for preventing iron deficiency anemia in infants in Brazil: something more is needed. (22344409)
2012
18
Effects of iron deficiency anemia and its treatment with iron polymaltose complex in pregnant rats, their fetuses and placentas: oxidative stress markers and pregnancy outcome. (22153683)
2012
19
Diagnostic yield of small-bowel capsule endoscopy in patients with iron-deficiency anemia: a systematic review. (23078923)
2012
20
Artificial intelligence models for predicting iron deficiency anemia and iron serum level based on accessible laboratory data. (21503744)
2012
21
Iron deficiency and iron-deficiency anemia in the first two years of life: strategies to prevent loss of developmental potential. (22043885)
2011
22
An unusual cause of iron deficiency anemia and abdominal pain in a young female. (21396329)
2011
23
Hereditary hyperferritinemia-cataract syndrome (HHCS) presenting with iron deficiency anemia associated with a new mutation in the iron responsive element of the L ferritin gene in a Swiss family. (21410535)
2011
24
A prospective evaluation of iron deficiency anemia in the GI endoscopy setting: role of standard endoscopy, videocapsule endoscopy, and CT-enteroclysis. (21396638)
2011
25
Iron deficiency anemia and its treatment - reply. (23049306)
2011
26
An interesting case of iron deficiency anemia. (20620279)
2010
27
Asymptomatic malaria in the etiology of iron deficiency anemia: a nutritionist's viewpoint. (21068349)
2010
28
Diagnosis and management of iron deficiency anemia in patients with IBD. (20924367)
2010
29
Leukocyte DNA damage in children with iron deficiency anemia: effect of iron supplementation. (20169450)
2010
30
The effects of iron deficiency anemia on p wave duration and dispersion. (21243273)
2010
31
Identification of clinical and simple laboratory variables predicting responsible gastrointestinal lesions in patients with iron deficiency anemia. (21209799)
2010
32
Soluble transferrin receptor-ferritin index and estimated body iron in iron-deficiency anemia in "select" chronic diseases. (19137299)
2009
33
Profound iron deficiency anemia caused by a small-intestinal cavernous hemangioma. (19481664)
2009
34
Red blood cell flags for the differential diagnosis between thalassemia trait and iron deficiency anemia. (19843389)
2009
35
Appropriateness of colonoscopy in Europe (EPAGE II). Iron-deficiency anemia and hematochezia. (19280534)
2009
36
Education and improved iron intakes for treatment of mild iron-deficiency anemia in adolescent girls in southern Benin. (19445257)
2009
37
Tumor necrosis factor SNP haplotypes are associated with iron deficiency anemia in West African children. (18716131)
2008
38
Pencil cells and prekeratocytes in iron deficiency anemia. (18932191)
2008
39
Discrimination indices have no predictive value in differential diagnosis of iron deficiency anemia and beta-thalassemia trait. (18371062)
2008
40
Red cell distribution width in iron deficiency anemia and beta-thalassemia minor. (18697290)
2008
41
Prevalence of iron deficiency anemia in chronic diarrhoea and celiac disease - a western UP experience. (23100934)
2008
42
Increased plasma malondialdehyde and fructosamine in iron deficiency anemia: effect of treatment. (17698317)
2007
43
Treatment of iron deficiency anemia in orthopedic surgery with intravenous iron: efficacy and limits: a prospective study. (18043060)
2007
44
Prevalence of iron deficiency and iron deficiency anemia among three populations of female military personnel in the US Army. (16522934)
2006
45
Iron deficiency anemia with marked thrombocytosis complicated by central retinal vein occlusion. (16293924)
2005
46
Soluble transferrin receptor and immature reticulocytes are not useful for distinguishing iron-deficiency anemia from heterozygous beta-thalassemia. (12870058)
2003
47
Thrombocytosis in children with iron deficiency anemia: series of 42 children. (12368707)
2002
48
Treatment of iron deficiency anemia and associated protein-losing enteropathy in children. (10695822)
2000
49
Immunohistochemistry of the Hfe protein in patients with hereditary hemochromatosis, iron deficiency anemia, and normal controls. (10772870)
2000
50
Plasma erythropoietic activity in healthy children and in children with iron-deficiency anemia]. (8054570)
1993

Variations for Iron Deficiency Anemia

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Expression for genes affiliated with Iron Deficiency Anemia

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Iron Deficiency Anemia

Search GEO for disease gene expression data for Iron Deficiency Anemia.

Pathways for genes affiliated with Iron Deficiency Anemia

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Sources:
51PathCards, 39NCBI BioSystems Database, 56Reactome, 31KEGG
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Compounds for genes affiliated with Iron Deficiency Anemia

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Sources:
46Novoseek, 12DrugBank, 30IUPHAR, 25HMDB, 52PharmGKB, 62Tocris Bioscience
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Compounds related to Iron Deficiency Anemia according to GeneCards/GeneDecks:

(show top 50)    (show all 74)
idCompoundScoreTop Affiliating Genes
1anagrelide46 1210.9EPO, THPO
2pixy321469.9EPO, THPO
3amifostine46 1210.8EPO, THPO
4filgrastim46 1210.8THPO, EPO
5pyronin y469.7THPO, TFRC
6benzidine469.7TFRC, EPO
7cobalt chloride469.7TFRC, EPO
8ferric gluconate469.6TF, EPO
9recormon469.6TF, EPO
10iron sucrose469.6EPO, TF
11nandrolone decanoate46 1210.6EPO, TF
12fenton469.5TF, EPO
13gm-csf46 3010.5THPO, EPO
14triamcinolone acetonide46 3010.5EPO, TF
15aluminium citrate469.5TF, TFRC
16gallium469.4TFRC, TF
17bismuth46 2510.4TF, TFRC
18apotransferrin469.4TF, TFRC
19ferric ammonium citrate469.4TF, TFRC
20methylcellulose469.3EPO, THPO, TFRC
21tbps46 3010.3TF, TFRC
22hydroxyurea46 52 1211.3EPO, THPO, TFRC
23cytarabine46 52 1211.3TFRC, THPO, EPO
24fe3+469.3TF, TFRC
25nh4cl469.2TF, TFRC
26butyrate469.1TFRC, THPO, EPO
27fe2+469.1TFRC, TF
28rapamycin469.1EPO, THPO, TFRC
29ifosfamide46 1210.0THPO, TF
30deferiprone469.0TF, TFRC, EPO
31aluminium46 1210.0EPO, TFRC, TF
32iron dextran46 1210.0EPO, TFRC, TF
33succinylacetone469.0TF, TFRC, EPO
34zinc protoporphyrin469.0EPO, TFRC, TF
35protoporphyrin ix46 25 1211.0TF, TFRC, EPO
36deferoxamine46 1210.0EPO, TFRC, TF
37vitamin b12469.0TF, TFRC, EPO
38ly294002469.0EPO, THPO, TFRC
39folate468.9EPO, TFRC, TF
40polyethylene glycol468.9TF, TFRC, THPO
41ascorbic acid46 259.9EPO, TFRC, TF
42polysaccharide468.8THPO, TFRC, TF
43bafilomycin a146 62 1210.7TFRC, TF
44histamine46 30 2510.7THPO, TFRC, TF
45cyclosporin a46 30 6210.6EPO, TFRC, TF
46sialic acid468.5EPO, THPO, TFRC, TF
47lactate468.5EPO, THPO, TFRC, TF
48creatinine468.4TF, TFRC, THPO, EPO
49vegf468.4TF, TFRC, THPO, EPO
50iron46 258.6HFE2, EPO, TMPRSS6, THPO, TFRC, TF

GO Terms for genes affiliated with Iron Deficiency Anemia

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17Gene Ontology
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Cellular components related to Iron Deficiency Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:0725629.0TFRC, TF
2coated pitGO:0059058.9TFRC, TF
3cytoplasmic membrane-bounded vesicleGO:0160238.7TFRC, TF
4cell surfaceGO:0099868.1TF, TFRC, EPO, HFE2
5extracellular spaceGO:0056157.6HFE2, EPO, THPO, TFRC, TF

Biological processes related to Iron Deficiency Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1iron ion homeostasisGO:0550729.4HFE2, TMPRSS6
2cellular iron ion homeostasisGO:0068799.0TFRC, TF
3transferrin transportGO:0335728.7TFRC, TF

Molecular functions related to Iron Deficiency Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.5EPO, THPO

Products for genes affiliated with Iron Deficiency Anemia

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  • Antibodies
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Sources for Iron Deficiency Anemia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet