MCID: IRN001
MIFTS: 61

Iron Deficiency Anemia malady

Immune diseases, Blood diseases categories

Summaries for Iron Deficiency Anemia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Iron-deficiency anemia (or iron-deficiency anaemia) is a common anemia (low red blood cell or hemoglobin... more...

MalaCards: Iron Deficiency Anemia is related to deficiency anemia and iron-refractory iron deficiency anemia. An important gene associated with Iron Deficiency Anemia is TMPRSS6 (transmembrane protease, serine 6), and among its related pathways are HIF-1 signaling pathway and Zinc transporters. The drugs iron-dextran complex and ferric oxide and the compounds fenton and deferiprone have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and testes, and related mouse phenotypes are integument and growth/size.

Aliases & Classifications for Iron Deficiency Anemia

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8Disease Ontology, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases, Blood diseases


Aliases & Descriptions:

iron deficiency anemia 8 44 60


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Disease Ontology8 DOID:11758
MeSH34 D018798
ICD9CM27 280.8
ICD1025 D50

Related Diseases for Iron Deficiency Anemia

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17GeneCards, 18GeneDecks
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Diseases related to Iron Deficiency Anemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 202)
idRelated DiseaseScoreTop Affiliating Genes
1deficiency anemia32.2TMPRSS6, FECH, HEPH, IREB2, HAMP, G6PD
2iron-refractory iron deficiency anemia31.0TMPRSS6
3beta thalassemia30.9HFE, TFRC, TF
4thrombocytosis30.9EPO, IL11, THPO
5celiac disease30.8TFRC, HFE
6hemosiderosis30.7TF, HFE, EPO
7microcytic anemia30.6SLC11A2, EPO, TFRC, TF, G6PD
8iron metabolism disease30.5HFE
9malaria30.5G6PD, TFRC
10arthritis30.5LTF, HFE, TFR2
11sickle cell disease30.5HBG2, EPO, TFRC, TF, G6PD
12hemolytic anemia30.5G6PD, TF, TFRC, HFE, EPO, HBG2
13thrombocytopenia30.5HFE, EPO, IL11, THPO
14rheumatoid arthritis30.5THPO, IL11, LTF, HFE, TFRC
15restless legs syndrome30.3TFRC, TF
16obesity30.3HFE, TFRC
17hypochromic microcytic anemia30.3SLC11A2, TF
18folic acid deficiency anemia30.3TFRC, EPO
19hemoglobinopathy30.3G6PD, TF, TFRC, HFE, EPO
20hemochromatosis30.3HAMP, HEPH, TF, TFR2, TMPRSS6, ACO1
21cataract30.1G6PD
22adenocarcinoma30.1FECH
23purpura30.1THPO
24hypogonadism30.1HFE, TF
25congenital hemolytic anemia30.1G6PD, TF
26chronic kidney failure30.1THPO, EPO, LTF, TF
27alzheimer's disease30.1IREB2, HFE, IL11, SLC11A2
28diabetes mellitus30.1G6PD, TF, HFE
29thalassemia10.8
30inflammatory bowel disease10.6
31cerebritis10.5
32gastritis10.5
33kidney disease10.5
34hemangioma10.5
35retinitis10.4
36cavernous hemangioma10.4
37papilledema10.4
38stroke, ischemic10.3
39atrophic gastritis10.3
40sickle cell anemia10.3
41giardiasis10.3
42hypochromic anemia10.3
43duodenitis10.3
44adenoma10.3
45hereditary hemorrhagic telangiectasia10.2
46pancytopenia10.2
47gastric antral vascular ectasia10.2
48central retinal vein occlusion10.2
49intussusception10.2
50protein-losing enteropathy10.2

Graphical network of the top 20 diseases related to Iron Deficiency Anemia:



Diseases related to iron deficiency anemia

Clinical Features for Iron Deficiency Anemia

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Drugs & Therapeutics for Iron Deficiency Anemia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Iron Deficiency Anemia

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Anatomical Context for Iron Deficiency Anemia

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32MalaCards
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MalaCards organs/tissues related to Iron Deficiency Anemia:

32
Kidney, Heart, Testes, Colon, Small intestine, Bone, Bone marrow, Placenta, Brain, Eye, Liver, Lung, Thyroid, Breast

Animal Models for Iron Deficiency Anemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Iron Deficiency Anemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107719.5HEPH, FECH, HFE2, SLC11A2, TMPRSS6
2MP:00053789.2HAMP, G6PD, TF, TFR2, TFRC, HFE
3MP:00053709.0HEPH, FECH, IREB2, TFR2, TFRC, HFE
4MP:00053878.7HEPH, FECH, IREB2, HAMP, TFR2, TFRC
5MP:00107688.7TF, G6PD, HAMP, IREB2, FECH, TFRC
6MP:00053978.5TMPRSS6, HEPH, FECH, IREB2, HAMP, G6PD
7MP:00053768.4TFR2, TF, G6PD, HAMP, IREB2, FECH

Publications for Iron Deficiency Anemia

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50PubMed
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Articles related to Iron Deficiency Anemia:

(show top 50)    (show all 670)
idTitleAuthorsYear
1
Treatment of iron-deficiency anemia in patients with subclinical hypothyroidism. (23582934)
2013
2
Human serum transferrin: is there a link among autism, high oxalate levels, and iron deficiency anemia? (24152109)
2013
3
Giant Brunner's Gland Adenoma of the Proximal Jejunum Presenting as Iron Deficiency Anemia and Mimicking Intussusceptions. (23422840)
2013
4
What do we know about the long-term cognitive effects of iron-deficiency anemia in infancy? (23464758)
2013
5
A study on the effects of pica and iron-deficiency anemia on oxidative stress, antioxidant capacity and trace elements. (23444335)
2013
6
Anemia and iron deficiency in heart failure. (24216080)
2013
7
Determination of total oxidative stress and total antioxidant capacity before and after the treatment of iron-deficiency anemia. (23440750)
2013
8
Prevalence of high blood pressure, heart disease, thalassemia, sickle-cell anemia, and iron-deficiency anemia among the UAE adolescent population. (23606864)
2013
9
Mild maternal iron deficiency anemia induces DPOAE suppression and cochlear hair cell apoptosis by caspase activation in young guinea pigs. (24378594)
2013
10
Hematologic manifestations of systemic disease (including iron deficiency, anemia of inflammation and DIC). (24237974)
2013
11
A case of pica-like, nutrient-induced, severe iron-deficiency anemia. (24262730)
2013
12
Association between thrombocytosis and iron deficiency anemia in inflammatory bowel disease. (23839158)
2013
13
Bed bugs reproductive life cycle in the clothes of a patient suffering from Alzheimer's disease results in iron deficiency anemia. (23673315)
2013
14
Efficacy of Trikatrayadi Lauha in Panduroga with reference to Iron Deficiency Anemia. (23049186)
2012
15
Artificial intelligence models for predicting iron deficiency anemia and iron serum level based on accessible laboratory data. (21503744)
2012
16
Cord blood iron profile and breast milk micronutrients in maternal iron deficiency anemia. (21548016)
2012
17
Polysaccharide isolated from Angelica sinensis inhibits hepcidin expression in rats with iron deficiency anemia. (22985399)
2012
18
Iron deficiency anemia in pregnancy: intravenous versus oral route. (23730037)
2012
19
The role of diet in predicting iron deficiency anemia in HIV-positive women. (22958630)
2012
20
Iron and ferritin levels in saliva of patients with thalassemia and iron deficiency anemia. (22973495)
2012
21
Iron deficiency anemia and its treatment. (23049304)
2011
22
Iron deficiency anemia: focus on infectious diseases in lesser developed countries. (21738863)
2011
23
Surgically curable non-iron deficiency microcytic anemia: Castleman's disease. (21934347)
2011
24
FERGIcor, a randomized controlled trial on ferric carboxymaltose for iron deficiency anemia in inflammatory bowel disease. (21699794)
2011
25
Iron deficiency anemia - a rare etiology of sinus thrombosis in adults. (20714964)
2010
26
Developmental profile in children with iron deficiency anemia and its changes after therapeutic iron supplementation. (20428973)
2010
27
Worms in the bowel: a cause of iron-deficiency anemia. (19278907)
2010
28
Upper and lower gastrointestinal causes of iron deficiency anemia in elderly compared with adult outpatients. (21139539)
2010
29
Incidence of koilonychia and atrophy of the lingual papillae in a patient with iron-deficiency anemia. (20127526)
2010
30
Red blood cell flags for the differential diagnosis between thalassemia trait and iron deficiency anemia. (19843389)
2009
31
Giant ulcerated lipoma of the colon causing iron deficiency anemia successfully treated with endoscopic ultrasound-assisted resection. (19738527)
2009
32
Celiac disease prevalence in patients with iron deficiency anemia of obscure origin. (20084570)
2009
33
Association between iron deficiency anemia and first febrile convulsion: A case-control study. (19223207)
2009
34
Intravenous iron without erythropoietin for the treatment of iron deficiency anemia in patients with moderate to severe congestive heart failure and chronic kidney insufficiency. (18446719)
2008
35
Comparative efficacy and safety of intravenous ferric carboxymaltose in the treatment of postpartum iron deficiency anemia. (18234203)
2008
36
Multiple cavernous hemangiomas with iron deficiency anemia successfully treated with double-balloon enteroscopy. (18155208)
2008
37
The effect of iron deficiency anemia on intelligence quotient (IQ) in under 17 years old students. (18817277)
2008
38
Maternal reports of sleep in 6-18 month-old infants from Nepal and Zanzibar: association with iron deficiency anemia and stunting. (18022771)
2008
39
Efficacy and safety of intravenous iron sucrose therapy in a group of children with iron deficiency anemia. (18605353)
2008
40
Seroprevalence of Helicobacter pylori infection in children in northwest region of Turkey: relationship with iron deficiency anemia. (18443008)
2008
41
Increased plasma malondialdehyde and fructosamine in iron deficiency anemia: effect of treatment. (17698317)
2007
42
Effect of oral tetracycline on iron absorption from iron(III)-hydroxide polymaltose complex in patients with iron deficiency anemia / a single-centre randomized controlled isotope study. (17691587)
2007
43
Assessment of paraoxonase and arylesterase activities in patients with iron deficiency anemia. (16684543)
2007
44
Iron deficiency anemia with marked thrombocytosis complicated by central retinal vein occlusion. (16293924)
2005
45
Soluble transferrin receptor and erythropoietin in chronic disease anemia with or without iron deficiency]. (11725764)
2001
46
Central retinal vein occlusion and nonarteritic ischemic optic neuropathy in 2 patients with mild iron deficiency anemia. (11244344)
2001
47
Atrial natriuretic peptide in aged patients with iron deficiency anemia. (15374090)
1999
48
Iron deficiency anemia in hemoglobinopathy. (8213774)
1993
49
Reversible papilledema in iron deficiency anemia. Two cases with normal spinal fluid pressure. (5035070)
1972
50
Multiple precipitins to cow's milk in chronic respiratory disease. A syndrome including poor growth, gastrointestinal symptoms, evidence of allergy, iron deficiency anemia, and pulmonary hemosiderosis. (13906070)
1962

Genetic Variations for Iron Deficiency Anemia

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Expression for genes affiliated with Iron Deficiency Anemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Iron Deficiency Anemia

Search GEO for disease gene expression data for Iron Deficiency Anemia.

Pathways for genes affiliated with Iron Deficiency Anemia

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29KEGG, 53Reactome, 37NCBI BioSystems Database
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Compounds for genes affiliated with Iron Deficiency Anemia

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44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB
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Compounds related to Iron Deficiency Anemia according to GeneCards/GeneDecks:

(show top 50)    (show all 110)
idCompoundScoreTop Affiliating Genes
1fenton4410.7HBG2
2deferiprone4410.6TFRC, TF, EPO
3aluminium44 1111.6EPO, TFRC, TF
4iron dextran44 1111.5TFRC, EPO, TF
5bismuth44 2411.5TF, LTF, TFRC
6apotransferrin4410.5TF, LTF, TFRC
723-diphosphoglycerate4410.5G6PD, HBG2, EPO
8protoporphyrin ix44 11 2412.4TF, FECH, TFRC, EPO
9recormon4410.4EPO, TF
10pixy3214410.4THPO, IL11, EPO
11succinylacetone4410.4EPO, TF, IREB2, TFRC
12amifostine44 1111.4EPO, IL11, THPO
13filgrastim44 1111.4EPO, THPO, IL11
14zinc protoporphyrin4410.4TFRC, TF, G6PD, EPO, FECH
15fecl34410.3LTF, TF
16methylcellulose4410.3EPO, TFRC, THPO, IL11
17aluminium citrate4410.3TFRC, TF
18copper44 2411.3SLC11A2, HEPH, SLC40A1, FECH
19ribavirin44 49 1112.3TF, G6PD, LTF, EPO
20vitamin b124410.3LTF, G6PD, TF, TFRC, EPO
21haem4410.3HFE, SLC11A2, FECH
22hydroxyurea44 49 1112.3TFRC, HBG2, THPO, EPO
23sialic acid4410.3EPO, THPO, LTF, TFRC, TF
24ferric gluconate4410.3TF, EPO
25ferric ammonium citrate4410.2IREB2, TFRC, ACO1, LTF, TF
26n-ethylmaleimide44 1111.2IREB2, G6PD, TFRC, ACO1, HBG2
27polyethylene glycol4410.2G6PD, TFRC, HBG2, IL11, TF, THPO
28cytarabine44 49 1112.2IL11, TFRC, EPO, THPO
29azathioprine44 49 2 1113.2LTF, IL11, G6PD, EPO
308-aminoquinoline4410.1G6PD, HBG2
31tocopherol4410.1TF, HBG2, G6PD
32oxygen44 2411.1IL11, HAMP, IREB2, EPO, ACO1
33lactate4410.1G6PD, EPO, TFRC, TF, THPO, HBG2
34sodium nitroprusside4410.1G6PD, TF, TFRC, ACO1, HBG2, IREB2
355-aminolevulinic acid44 2411.1ACO1, SLC11A2, HFE, TFRC, IREB2, FECH
36epinephrine44 11 2412.1G6PD, HBG2, THPO, TF, IL11
37aspartate4410.0TF, G6PD, IL11, TFRC, HFE, LTF
38ascorbic acid44 2411.0HBG2, EPO, TFRC, LTF, G6PD, SLC11A2
39citrate4410.0ACO1, SLC11A2, IREB2, LTF, TFRC, TF
40superoxide44 2411.0FECH, ACO1, THPO, HBG2, LTF, G6PD
41creatinine4410.0G6PD, TF, TFRC, LTF, HBG2, THPO
42h2o2449.9G6PD, HBG2, THPO, IREB2, LTF, ACO1
43cis-aconitate449.9LTF, ACO1
44fe3+449.9TFRC, FECH, IREB2, TF, ACO1, SLC11A2
45n acetylcysteine449.9TFRC, ACO1, IREB2, HBG2, G6PD, TF
46alanine449.8TF, HBG2, THPO, LTF, IL11, FECH
47fe2+449.8SLC40A1, SLC11A2, ACO1, HBG2, LTF, HFE
48cysteine449.6TFRC, ACO1, LTF, FECH, IL11, IREB2
49deferoxamine44 1110.6IREB2, ACO1, EPO, HBG2, LTF, TFRC
50iron44 249.5IL11, FECH, HEPH, IREB2, HAMP, TF

GO Terms for genes affiliated with Iron Deficiency Anemia

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16Gene Ontology
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Cellular components related to Iron Deficiency Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basal part of cellGO:04517810.2SLC11A2, HFE, TF
2recycling endosomeGO:05503710.1SLC11A2, HFE, TF
3perinuclear region of cytoplasmGO:0484719.8HEPH, TF, TFRC, HFE, SLC11A2
4integral to plasma membraneGO:0058879.7TMPRSS11A, SLC40A1, SLC11A2, HFE, TFRC, TFR2
5extracellular regionGO:0055769.3HAMP, TF, TFRC, LTF, EPO, IL11

Biological processes related to Iron Deficiency Anemia according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1multicellular organismal iron ion homeostasisGO:06058610.3SLC40A1, SLC11A2, HFE
2iron ion homeostasisGO:05507210.3FECH, HFE2, TMPRSS6
3response to iron(II) ionGO:01004010.2ACO1, IREB2
4copper ion transportGO:00682510.2SLC11A2, HEPH
5iron ion transportGO:00682610.0HEPH, IREB2, TFR2, LTF
6intestinal absorptionGO:05089210.0ACO1, IREB2
7erythrocyte maturationGO:04324910.0EPO, G6PD
8proteolysisGO:0065089.9TFR2, TFRC, LTF, TMPRSS6, TMPRSS11A
9transmembrane transportGO:0550859.8HEPH, TF, TFRC, SLC11A2, SLC40A1
10cellular iron ion homeostasisGO:0068799.3ACO1, HEPH, IREB2, HAMP, TF, TFR2

Molecular functions related to Iron Deficiency Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ferric iron bindingGO:00819910.2LTF, TF
2transferrin receptor activityGO:00499810.2TFRC, TFR2
3iron-responsive element bindingGO:03035010.1ACO1, IREB2, FECH
4hormone activityGO:0051799.8THPO, EPO, HAMP
5protein bindingGO:0055158.7TFRC, TF, G6PD, IREB2, FECH, HFE

Products for genes affiliated with Iron Deficiency Anemia

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  • Antibodies
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Sources for Iron Deficiency Anemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet