MCID: IRN001
MIFTS: 58

Iron Deficiency Anemia malady

Immune, Blood categories

Summaries for Iron Deficiency Anemia

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Iron-deficiency anemia (or iron-deficiency anaemia) is a common anemia (low red blood cell or hemoglobin... more...

MalaCards: Iron Deficiency Anemia is related to deficiency anemia and iron-refractory iron deficiency anemia. An important gene associated with Iron Deficiency Anemia is TMPRSS6 (transmembrane protease, serine 6), and among its related pathways are HIF-1 signaling pathway and Zinc transporters. The drugs iron-dextran complex and ferric oxide and the compounds fenton and deferiprone have been mentioned in the context of this disorder. Affiliated tissues include liver, spinal cord and brain, and related mouse phenotypes are integument and growth/size.

Aliases & Classifications for Iron Deficiency Anemia

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 35MeSH, 57SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune, Blood


Aliases & Descriptions:

iron deficiency anemia 8 45 61


External Ids:

Disease Ontology8 DOID:11758
MeSH35 D018798
ICD9CM27 280.8
ICD1025 D50

Related Diseases for Iron Deficiency Anemia

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Iron Deficiency Anemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 195)
idRelated DiseaseScoreTop Affiliating Genes
1deficiency anemia32.2HAMP, TMPRSS6, SLC40A1, SLC11A2, THPO, IL11
2iron-refractory iron deficiency anemia31.3TMPRSS6
3thalassemia31.2HFE, EPO, HBG2, SLC11A2, TFRC, TF
4refractory anemia31.1THPO, EPO, TFRC, IL11
5beta thalassemia31.0TFRC, HFE, TF
6thrombocytosis30.9EPO, IL11, THPO
7celiac disease30.9HFE, TFRC
8hemosiderosis30.8TF, HFE, EPO
9arthritis30.5LTF, TFR2, HFE
10sickle cell disease30.5G6PD, HBG2, EPO, TFRC, TF
11thrombocytopenia30.5THPO, IL11, EPO, HFE
12restless legs syndrome30.4TF, TFRC
13hypochromic microcytic anemia30.4SLC11A2, TF
14folic acid deficiency anemia30.4TFRC, EPO
15hemochromatosis30.3HEPH, IREB2, HAMP, TF, TFR2, TFRC
16adenocarcinoma30.1FECH
17pouchitis30.1LTF
18hyperferritinemia cataract syndrome30.1HFE, TF
19alzheimer's disease30.1HFE, IREB2, IL11, SLC11A2
20t cell deficiency10.7
21b cell deficiency10.7
22thalassemia minor10.6
23h. pylori infection10.6
24protein-deficiency anemia10.5
25protein c deficiency10.4
26stroke, ischemic10.4
27atrophic gastritis10.4
28sickle cell anemia10.4
29giardiasis10.4
30protein s deficiency10.4
31hypochromic anemia10.4
32n syndrome10.4
33adenoma10.4
34decr deficiency10.4
35cerebral sinovenous thrombosis10.4
36hereditary hemorrhagic telangiectasia10.3
37pancytopenia10.3
38gastric antral vascular ectasia10.3
39central retinal vein occlusion10.3
40intussusception10.3
41protein-losing enteropathy10.3
42peutz-jeghers syndrome10.3
43congenital diaphragmatic hernia10.3
44amyloidosis10.3
45peutz–jeghers syndrome10.3
46factor 2 deficiency10.3
47protein r deficiency10.3
48febrile seizures10.3
49venous thrombosis10.3
50branch retinal artery occlusion10.1

Graphical network of the top 20 diseases related to Iron Deficiency Anemia:



Diseases related to iron deficiency anemia

Clinical Features for Iron Deficiency Anemia

Drugs & Therapeutics for Iron Deficiency Anemia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Genetic Tests for Iron Deficiency Anemia

Anatomical Context for Iron Deficiency Anemia

Sources:
33MalaCards
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MalaCards organs/tissues related to Iron Deficiency Anemia:

33
Liver, Spinal cord, Brain, Kidney, Lung, Bone marrow, Whole blood, Heart, Small intestine, Colon, Thyroid, Salivary gland, Breast, Placenta, T cells, Fetal brain, Fetal liver, Fetal lung, Fetal thyroid

Animal Models for Iron Deficiency Anemia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Iron Deficiency Anemia

Sources:
51PubMed
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Articles related to Iron Deficiency Anemia:

(show top 50)    (show all 658)
idTitleAuthorsYear
1
Positive relationship between a polymorphism in Helicobacter pylori neutrophil-activating protein a gene and iron-deficiency anemia. (23067298)
2013
2
Combined cobalamin and iron deficiency anemia: a diagnostic approach using a model based on age and homocysteine assessment. (23183879)
2013
3
Cerebral venous sinus thrombosis in a child with iron-deficiency anemia. (23553265)
2013
4
Heme iron polypeptide for the treatment of iron deficiency anemia in non-dialysis chronic kidney disease patients: a randomized controlled trial. (23514036)
2013
5
Diagnostic choices and clinical outcomes in octogenarians and nonagenarians with iron-deficiency anemia in the Netherlands. (23521576)
2013
6
A forgotten screening test for iron deficiency anemia: Oral iron absorption test. (24424212)
2013
7
Comparison of discriminative indices for iron deficiency anemia and I^ thalassemia trait in a Brazilian population. (23321282)
2013
8
Koilonychia in a patient with subacute iron-deficiency anemia. (24126407)
2013
9
Effects of iron deficiency anemia and its treatment with iron polymaltose complex in pregnant rats, their fetuses and placentas: oxidative stress markers and pregnancy outcome. (22153683)
2012
10
Systemic amyloidosis masquerading as iron deficiency anemia. (22903369)
2012
11
TMPRSS6, but not TF, TFR2 or BMP2 variants are associated with increased risk of iron-deficiency anemia. (22323359)
2012
12
Does wet-cupping (blood-letting cupping) cause iron deficiency anemia? Comments about "a prospective evaluation of adult men with iron-deficiency anemia in Korea" published in Internal Medicine. (22682275)
2012
13
High prevalence but insufficient treatment of iron-deficiency anemia in patients with inflammatory bowel disease: results of a population-based cohort. (22899905)
2012
14
Diagnostic yield of capsule endoscopy in the setting of iron deficiency anemia without evidence of gastrointestinal bleeding. (23061059)
2012
15
Avoiding biopsy in iron deficiency anemia is not a cost-effective approach. (22738709)
2012
16
Iron deficiency and iron-deficiency anemia in the first two years of life: strategies to prevent loss of developmental potential. (22043885)
2011
17
An unusual cause of iron deficiency anemia and abdominal pain in a young female. (21396329)
2011
18
Iron deficiency anemia: pregnancy outcomes with or without iron supplementation. (20381313)
2011
19
Social and biological determinants of iron deficiency anemia. (21789422)
2011
20
Soluble transferrin receptor as a diagnostic laboratory test for detection of iron deficiency anemia in acute illness of hospitalized patients. (21443035)
2011
21
Iron-deficiency anemia, non-iron-deficiency anemia and HbA1c among adults in the US. (20942846)
2011
22
Iron deficiency anemia presenting as pancytopenia in an adolescent girl. (21721367)
2011
23
The effects of iron deficiency anemia on p wave duration and dispersion. (21243273)
2010
24
Iron-deficiency anemia associated with hiatal hernia: case reports and literature review. (20837629)
2010
25
Diagnosis of iron deficiency anemia in children of Northeast Brazil. (20549021)
2010
26
Long-term impact of capsule endoscopy in patients referred for iron-deficiency anemia. (19941072)
2010
27
The effect of iron treatment on adhesion molecules in patients with iron deficiency anemia. (20039148)
2010
28
The prevalence of iron deficiency anemia in pregnant women in Nakhonsawan, Thailand. (20649053)
2010
29
Profound iron deficiency anemia caused by a small-intestinal cavernous hemangioma. (19481664)
2009
30
The causes of porotic hyperostosis and cribra orbitalia: a reappraisal of the iron-deficiency-anemia hypothesis. (19280675)
2009
31
Effect of soluble fiber pectin on growth and intestinal iron absorption in rats during recovery from iron deficiency anemia. (19183868)
2009
32
Red cell distribution width in iron deficiency anemia and beta-thalassemia minor. (18697290)
2008
33
Predictors of gastrointestinal lesions on endoscopy in iron deficiency anemia without gastrointestinal symptoms. (18992171)
2008
34
Usefulness of red blood cell flags in diagnosing and differentiating thalassemia trait from iron-deficiency anemia. (18796253)
2008
35
Iron deficiency anemia. (18390780)
2008
36
Ineffectiveness of oral iron hydroxide polymaltose in iron-deficiency anemia. (17558703)
2007
37
Iron deficiency anemia in infancy is associated with altered temporal organization of sleep states in childhood. (17957147)
2007
38
Prevalence of anemia and deficiency of iron, folic acid, and zinc in children younger than 2 years of age who use the health services provided by the Mexican Social Security Institute. (18053140)
2007
39
Effects of H pylori therapy on erythrocytic and iron parameters in iron deficiency anemia patients with H pylori-positive chronic gastristis. (17879411)
2007
40
Neutrophil hypersegmentation and thrombocytosis in children with iron deficiency anemia. (16250310)
2005
41
Carbohydrate-deficient isoforms of transferrin (%CDT) and sialic acid (SA) in iron-deficiency anemia. (16178908)
2005
42
Association between iron deficiency anemia and febrile seizures. (15924837)
2005
43
High serum transferrin receptor level in anemia of chronic disorders indicates coexistent iron deficiency. (12605386)
2003
44
Amino acid sequence homology of thrombopoietin and erythropoietin may explain thrombocytosis in children with iron deficiency anemia. (12902931)
2003
45
Erythropoietin in the treatment of iron deficiency anemia during pregnancy. (11306899)
2001
46
Thrombopoietic cytokines in patients with iron deficiency anemia with or without thrombocytosis. (10940653)
2000
47
Quantitative determinations of microcytic-hypochromic red blood cell population and glycerol permeability in iron-deficiency anemia and beta thalassemia minor. (10550558)
1999
48
Is serum transferrin receptor a sensitive marker of iron repletion in patients with iron-deficiency anemia and hemodialysis patients? (10367478)
1999
49
Decreased erythropoietin responsiveness to iron deficiency anemia in the elderly. (8352231)
1993
50
Is trichuriasis associated with iron deficiency anemia? (464198)
1979

Genetic Variations for Iron Deficiency Anemia

Expression for genes affiliated with Iron Deficiency Anemia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Iron Deficiency Anemia

Search GEO for disease gene expression data for Iron Deficiency Anemia.

Pathways for genes affiliated with Iron Deficiency Anemia

Sources:
30KEGG, 54Reactome, 38NCBI BioSystems Database
See all sources

Compounds for genes affiliated with Iron Deficiency Anemia

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 2BitterDB
See all sources

Compounds related to Iron Deficiency Anemia according to GeneCards/GeneDecks:

(show top 50)    (show all 110)
idCompoundScoreTop Affiliating Genes
1fenton4510.7HBG2
2deferiprone4510.6TFRC, TF, EPO
3aluminium45 1111.6EPO, TFRC, TF
4iron dextran45 1111.5TFRC, EPO, TF
5bismuth45 2411.5TF, LTF, TFRC
6apotransferrin4510.5TF, LTF, TFRC
723-diphosphoglycerate4510.5G6PD, HBG2, EPO
8protoporphyrin ix45 11 2412.4TF, FECH, TFRC, EPO
9recormon4510.4EPO, TF
10pixy3214510.4THPO, IL11, EPO
11succinylacetone4510.4EPO, TF, IREB2, TFRC
12amifostine45 1111.4EPO, IL11, THPO
13filgrastim45 1111.4EPO, THPO, IL11
14zinc protoporphyrin4510.4TFRC, TF, G6PD, EPO, FECH
15fecl34510.3LTF, TF
16methylcellulose4510.3EPO, TFRC, THPO, IL11
17aluminium citrate4510.3TFRC, TF
18copper45 2411.3SLC11A2, HEPH, SLC40A1, FECH
19ribavirin45 50 1112.3TF, G6PD, LTF, EPO
20vitamin b124510.3LTF, G6PD, TF, TFRC, EPO
21haem4510.3HFE, SLC11A2, FECH
22hydroxyurea45 50 1112.3TFRC, HBG2, THPO, EPO
23sialic acid4510.3EPO, THPO, LTF, TFRC, TF
24ferric gluconate4510.3TF, EPO
25ferric ammonium citrate4510.2IREB2, TFRC, ACO1, LTF, TF
26n-ethylmaleimide45 1111.2IREB2, G6PD, TFRC, ACO1, HBG2
27polyethylene glycol4510.2G6PD, TFRC, HBG2, IL11, TF, THPO
28cytarabine45 50 1112.2IL11, TFRC, EPO, THPO
29azathioprine45 50 2 1113.2LTF, IL11, G6PD, EPO
308-aminoquinoline4510.1G6PD, HBG2
31tocopherol4510.1TF, HBG2, G6PD
32oxygen45 2411.1IL11, HAMP, IREB2, EPO, ACO1
33lactate4510.1G6PD, EPO, TFRC, TF, THPO, HBG2
34sodium nitroprusside4510.1G6PD, TF, TFRC, ACO1, HBG2, IREB2
355-aminolevulinic acid45 2411.1ACO1, SLC11A2, HFE, TFRC, IREB2, FECH
36epinephrine45 11 2412.1G6PD, HBG2, THPO, TF, IL11
37aspartate4510.0TF, G6PD, IL11, TFRC, HFE, LTF
38ascorbic acid45 2411.0HBG2, EPO, TFRC, LTF, G6PD, SLC11A2
39citrate4510.0ACO1, SLC11A2, IREB2, LTF, TFRC, TF
40superoxide45 2411.0FECH, ACO1, THPO, HBG2, LTF, G6PD
41creatinine4510.0G6PD, TF, TFRC, LTF, HBG2, THPO
42h2o2459.9G6PD, HBG2, THPO, IREB2, LTF, ACO1
43cis-aconitate459.9LTF, ACO1
44fe3+459.9TFRC, FECH, IREB2, TF, ACO1, SLC11A2
45n acetylcysteine459.9TFRC, ACO1, IREB2, HBG2, G6PD, TF
46alanine459.8TF, HBG2, THPO, LTF, IL11, FECH
47fe2+459.8SLC40A1, SLC11A2, ACO1, HBG2, LTF, HFE
48cysteine459.6TFRC, ACO1, LTF, FECH, IL11, IREB2
49deferoxamine45 1110.6IREB2, ACO1, EPO, HBG2, LTF, TFRC
50iron45 249.5IL11, FECH, HEPH, IREB2, HAMP, TF

GO Terms for genes affiliated with Iron Deficiency Anemia

Sources:
16Gene Ontology
See all sources

Cellular components related to Iron Deficiency Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basal part of cellGO:04517810.2SLC11A2, HFE, TF
2recycling endosomeGO:05503710.1TF, HFE, SLC11A2
3perinuclear region of cytoplasmGO:0484719.8SLC11A2, HFE, TFRC, TF, HEPH
4integral to plasma membraneGO:0058879.7TFRC, TMPRSS11A, SLC40A1, SLC11A2, HFE, TFR2
5extracellular regionGO:0055769.3TMPRSS11A, TF, IL11, EPO, LTF, TFRC

Biological processes related to Iron Deficiency Anemia according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1multicellular organismal iron ion homeostasisGO:06058610.3SLC40A1, SLC11A2, HFE
2iron ion homeostasisGO:05507210.3FECH, HFE2, TMPRSS6
3response to iron(II) ionGO:01004010.2ACO1, IREB2
4copper ion transportGO:00682510.2SLC11A2, HEPH
5iron ion transportGO:00682610.0HEPH, IREB2, TFR2, LTF
6intestinal absorptionGO:05089210.0ACO1, IREB2
7erythrocyte maturationGO:04324910.0EPO, G6PD
8proteolysisGO:0065089.9TFR2, TFRC, LTF, TMPRSS6, TMPRSS11A
9transmembrane transportGO:0550859.8HEPH, TF, TFRC, SLC11A2, SLC40A1
10cellular iron ion homeostasisGO:0068799.3ACO1, HEPH, IREB2, HAMP, TF, TFR2

Molecular functions related to Iron Deficiency Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ferric iron bindingGO:00819910.2TF, LTF
2transferrin receptor activityGO:00499810.2TFRC, TFR2
3iron-responsive element bindingGO:03035010.1FECH, IREB2, ACO1
4hormone activityGO:0051799.8THPO, EPO, HAMP
5protein bindingGO:0055158.7HFE2, FECH, IREB2, G6PD, TF, TFRC

Products for genes affiliated with Iron Deficiency Anemia

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Sources for Iron Deficiency Anemia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet