MCID: IRN002
MIFTS: 45

Iron Metabolism Disease

Categories: Immune diseases, Blood diseases, Metabolic diseases

Aliases & Classifications for Iron Metabolism Disease

Summaries for Iron Metabolism Disease

MedlinePlus : 40 Iron is a mineral that our bodies need for many functions. For example, iron is part of hemoglobin, a protein which carries oxygen from our lungs throughout our bodies. It helps our muscles store and use oxygen. Iron is also part of many other proteins and enzymes. Your body needs the right amount of iron. If you have too little iron, you may develop iron deficiency anemia. Causes of low iron levels include blood loss, poor diet, or an inability to absorb enough iron from foods. People at higher risk of having too little iron are young children and women who are pregnant or have periods. Too much iron can damage your body. Taking too many iron supplements can cause iron poisoning. Some people have an inherited disease called hemochromatosis. It causes too much iron to build up in the body. Centers for Disease Control and Prevention

MalaCards based summary : Iron Metabolism Disease, also known as iron deficiency, is related to iron-refractory iron deficiency anemia and iron deficiency anemia. An important gene associated with Iron Metabolism Disease is TF (Transferrin), and among its related pathways/superpathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Insulin receptor recycling. The drugs Zinc and Iron have been mentioned in the context of this disorder. Affiliated tissues include lung, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 72 Iron deficiency, or Sideropaenia, happens when a body has not enough (or not qualitatively enough) iron... more...

Related Diseases for Iron Metabolism Disease

Diseases related to Iron Metabolism Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Related Disease Score Top Affiliating Genes
1 iron-refractory iron deficiency anemia 34.2 EPO HFE2
2 iron deficiency anemia 31.7 EPO HFE HFE2 SLC11A2 SLC40A1 TF
3 ancylostomiasis 31.6 CP TF
4 microcytic anemia 31.2 EPO IREB2 SLC11A2 TF TFRC
5 aceruloplasminemia 30.6 CP TF TFR2
6 thalassemia 30.4 EPO HFE TF TFRC
7 hemosiderosis 29.3 CP EPO HFE SLC11A2 SLC40A1 TF
8 beta-thalassemia 29.3 EPO HFE TF TFR2 TFRC
9 deficiency anemia 28.4 CP EPO HFE HFE2 SLC11A2 SLC40A1
10 hemochromatosis, type 1 28.3 CP CYBRD1 HFE HFE2 IREB2 SLC11A2
11 autoimmune atrophic gastritis 11.3
12 atrophic gastritis 11.2
13 hernia, hiatus 11.1
14 gastric antral vascular ectasia 11.1
15 anemia, congenital dyserythropoietic, type iii 10.8
16 mucolipidosis iv 10.8
17 pulmonary arterio-veinous fistula 10.8
18 plummer vinson syndrome 10.7
19 anemia, hypochromic microcytic, with iron overload 1 10.6
20 iron overload in africa 10.4 HFE TF
21 hyperferritinemia with or without cataract 10.4 HFE TF
22 angiomatous meningioma 10.3 TF TFRC
23 aging 10.3
24 inflammatory bowel disease 10.2
25 fetal erythroblastosis 10.2 EPO TFRC
26 pure red-cell aplasia 10.2 EPO TF
27 thrombocytosis 10.2
28 celiac disease 1 10.2
29 gastritis 10.1
30 hemochromatosis, type 3 10.1 HFE TFR2
31 anemia, sideroblastic, 1 10.1
32 folic acid deficiency anemia 10.1 EPO TF TFRC
33 hemoglobinopathy 10.1 EPO HFE TF
34 hemoglobin h disease 10.1 EPO TF TFRC
35 hemochromatosis, type 4 10.0 SLC40A1 TFR2
36 analbuminemia 10.0 EPO TF
37 immune system disease 10.0 EPO TF TFRC
38 vitamin b12 deficiency 10.0 EPO TF
39 swayback 9.9 CP HFE
40 porphyria cutanea tarda 9.9 HFE HFE2 TF TFRC
41 siderosis 9.9 HFE SLC40A1 TF TFRC
42 eales disease 9.9 CP TF
43 epileptic encephalopathy, early infantile, 36 9.8 CP TF
44 wilson disease 9.8 CP HFE TF
45 hypochromic microcytic anemia 9.8 CP SLC11A2 TF
46 inherited metabolic disorder 9.7 HFE HFE2 TF TFR2
47 hfe-associated hereditary hemochromatosis 9.7 HFE HFE2 SLC11A2 TFR2
48 hepatitis 9.7
49 hepatitis c 9.7
50 hemochromatosis type 2 9.6 HFE HFE2 SLC40A1 TFR2

Comorbidity relations with Iron Metabolism Disease via Phenotypic Disease Network (PDN):


Deficiency Anemia Pulmonary Hemosiderosis

Graphical network of the top 20 diseases related to Iron Metabolism Disease:



Diseases related to Iron Metabolism Disease

Symptoms & Phenotypes for Iron Metabolism Disease

MGI Mouse Phenotypes related to Iron Metabolism Disease:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.07 CP SLC11A2 EPO SLC40A1 HFE TF
2 homeostasis/metabolism MP:0005376 10.06 CYBRD1 SLC11A2 EPO SLC40A1 HFE TF
3 cardiovascular system MP:0005385 10.01 IREB2 CP CYBRD1 SLC11A2 EPO SLC40A1
4 immune system MP:0005387 9.91 CP SLC11A2 EPO SLC40A1 HFE HFE2
5 liver/biliary system MP:0005370 9.65 CYBRD1 SLC11A2 EPO SLC40A1 HFE HFE2
6 integument MP:0010771 9.63 IREB2 SLC11A2 EPO SLC40A1 HFE2 TFRC
7 mortality/aging MP:0010768 9.23 IREB2 SLC11A2 EPO SLC40A1 HFE TF

Drugs & Therapeutics for Iron Metabolism Disease

Drugs for Iron Metabolism Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 265)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Zinc Approved, Investigational Phase 4,Phase 3,Not Applicable,Early Phase 1 7440-66-6 32051 23994
2
Iron Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 7439-89-6 23925
3
Omeprazole Approved, Investigational, Vet_approved Phase 4,Not Applicable 73590-58-6 4594
4
Copper Approved, Investigational Phase 4,Phase 3,Not Applicable 7440-50-8 27099
5
Selenium Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 7782-49-2
6
Iodine Approved, Investigational Phase 4,Phase 3,Not Applicable 7553-56-2 807
7
Metronidazole Approved Phase 4,Not Applicable 443-48-1 4173
8
Halofantrine Approved Phase 4 69756-53-2 37393
9
Hydroxocobalamin Approved Phase 4,Phase 2,Phase 3,Not Applicable 13422-51-0 5460373 44475014 11953898
10
Clarithromycin Approved Phase 4 81103-11-9 84029
11
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
12
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 68-26-8, 11103-57-4 445354
13
leucovorin Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 58-05-9 143 6006
14
Vitamin C Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 50-81-7 54670067 5785
15
Glycine Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 56-40-6 750
16
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 59-30-3 6037
17
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 4,Phase 3,Not Applicable 65-23-6 1054
18
Niacin Approved, Investigational, Nutraceutical Phase 4,Phase 3,Not Applicable 59-67-6 938
19
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Phase 4,Phase 3,Not Applicable 83-88-5 493570
20
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 1406-16-2
21
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 77-92-9 311
22
Nicotinamide Approved, Investigational, Nutraceutical Phase 4,Phase 3,Not Applicable 98-92-0 936
23
Thiamine Approved, Investigational, Nutraceutical, Vet_approved Phase 4,Phase 3,Not Applicable 59-43-8 1130
24
Pyridoxal Approved, Nutraceutical Phase 4,Phase 3,Not Applicable 66-72-8 1050
25 Tocopherol Approved, Investigational, Nutraceutical Phase 4,Phase 3,Phase 1,Not Applicable
26
Methylcobalamin Approved, Experimental, Investigational, Nutraceutical Phase 4,Phase 2,Phase 3,Not Applicable 13422-55-4
27
Cholecalciferol Approved, Nutraceutical Phase 4,Not Applicable 67-97-0 10883523 5280795 6221
28
Cyanocobalamin Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Not Applicable 68-19-9 44176380
29
Ergocalciferol Approved, Nutraceutical Phase 4,Not Applicable 50-14-6 5280793
30
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 1,Not Applicable 59-02-9 14985
31 ferric gluconate Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
32 Ferric Compounds Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
33 Ferric oxide, saccharated Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
34 Ferrous fumarate Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
35 Ferrous gluconate Phase 4,Phase 1,Not Applicable
36 Retinol palmitate Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
37 Micronutrients Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
38 Teferrol Phase 4,Phase 3,Not Applicable
39 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Not Applicable
40 Trace Elements Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
41 Hematinics Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
42 Hepcidins Phase 4,Phase 1,Phase 2,Not Applicable
43 Vitamin B Complex Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
44 Vitamins Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
45 Epoetin alfa Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 113427-24-0
46 cadexomer iodine Phase 4,Phase 3,Not Applicable
47 Ferrosoferric Oxide Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
48 Chelating Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
49 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1
50 Tocopherols Phase 4,Phase 3,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 530)

# Name Status NCT ID Phase Drugs
1 Prevention of Iron Deficiency in 2nd Year of Life Unknown status NCT00479102 Phase 4 Ferripel-3 - iron polysaccharide complex for prevention
2 Iron Therapy in Colo-Rectal Neoplasm and Iron Deficiency Anemia: Intravenous Iron Sucrose Versus Oral Ferrous Sulphate. Unknown status NCT00199277 Phase 4 i.v. iron sucrose;Oral iron
3 Different Iron Supplements for Prevention of Anemia in Pregnancy Unknown status NCT02487719 Phase 4 Iron sulfate and Iron polymaltose for prevention of iron deficiency anemia
4 Nutrient Fortified Oat Drink Unknown status NCT01418898 Phase 4
5 Iron Deficiency In Pulmonary Hypertension Unknown status NCT01288651 Phase 4 Ferricarboxymaltose
6 Effect Of Intravenous Iron Versus Placebo On Muscle Oxidative Capacity And Physical Performance In Non Anemic Premenopausal Women With Low Ferritin Levels Unknown status NCT01374776 Phase 4 Double blind, randomized, placebo controlled inter
7 Treatment of Anemia in the 2nd Year of Life. Comparison of the Efficacy of Two Different Iron Preparations. Unknown status NCT00248716 Phase 4 Ferrous gluconate and iron polysaccharide complex
8 Iron Supplementation of Marginally Low Birth Weight Infants Unknown status NCT00558454 Phase 4 Iron
9 Iron Absorption Trial Unknown status NCT02228902 Phase 4 Ferrous fumarate;Ferrous gluconate
10 Prevention of Iron Deficiency in Breastfed Infants Completed NCT01444261 Phase 4
11 Restless Legs Syndrome With Iron Deficiency or Anaemia in the 3rd Trimester of Pregnancy Completed NCT01245777 Phase 4 ferric carboxymaltose
12 Iron Supplementation Using Total Dose Infusion and Oral Routes for Treatment of Iron Deficiency Anemia in Pregnancy Completed NCT02086838 Phase 4 Theragran Hematinic;low molecular weight iron dextran
13 The Effect of Iron Deficiency Anemia During Pregnancy Completed NCT02590224 Phase 4 Ferrous bis-glycinate;Ferrous glycine sulphate
14 A Trial of Iron Replacement in Patients With Iron Deficiency. Completed NCT01067547 Phase 4 Iron Sucrose.;Iron sucrose
15 Comparison of NovaFerrum® vs Ferrous Sulfate Treatment in Young Children With Nutritional Iron Deficiency Anemia Completed NCT01904864 Phase 4 elemental iron (NovaFerrum®);elemental iron (Ferrous Sulfate)
16 Bovine Lactoferrin to Prevent and Cure Iron Deficiency and Iron Deficiency Anemia in Complicated Pregnancies Completed NCT01221844 Phase 4 FerroGrad by Abbott
17 A Study to Compare the Use of Ferric Carboxymaltose With Placebo in Patients With Chronic Heart Failure and Iron Deficiency Completed NCT01453608 Phase 4 Ferinject (ferric carboxymaltose);Placebo (saline)
18 A Phase IV Trial of Repeated Doses of Ferumoxytol Compared to Iron Sucrose for the Treatment of Iron Deficiency Anemia in Patients With Chronic Kidney Disease on Hemodialysis Completed NCT01227616 Phase 4 Ferumoxytol;Iron Sucrose
19 Efficacy and Safety Study of Iron Sucrose and Oral Iron Acetyl-transferrin Hydroglycerin Completed NCT00802139 Phase 4 venoferrum(iron sucrose);Bolgre (Iron acetyl-transferase)
20 Study of the Efficacy of Two Doses of Ferrlecit in the Treatment of Iron Deficiency in Pediatric Hemodialysis Patients Completed NCT00223964 Phase 4 Ferrlecit (sodium ferric gluconate complex in sucrose injection)
21 Treatment of Iron Deficiency Anaemia in Inflammatory Bowel Disease With Ferrous Sulphate Completed NCT01991314 Phase 4 Ferrous sulphate
22 Pilot Study of Ferric Carboxymaltose to Treat Iron Deficiency in Asians With Heart Failure Completed NCT01922479 Phase 4 Ferric Carboxymaltose;Placebo
23 Hospitalization & Mortality in Patients With Iron Deficiency CKD and HF Treated With i.v. Iron. Completed NCT02392910 Phase 4 Iron Sucrose;Placebo
24 Ferumoxytol for Iron-Deficiency Anemia in Chronic Kidney Disease and Peritoneal Dialysis Patients Completed NCT01942460 Phase 4 Ferumoxytol
25 Iron Substitution in Blood Donors Completed NCT01519830 Phase 4 Iron carboxymaltose (Ferinject);Placebo
26 Ferric Carboxymaltose Treatment to Improve Fatigue Symptoms in Iron-deficient Non-anaemic Women of Child Bearing Age Completed NCT01110356 Phase 4 Ferinject
27 Iron Indices and Intravenous Ferumoxytol: Time to Steady State Completed NCT01148745 Phase 4 ferumoxytol
28 Effectiveness of Selling Micronutrient Sprinkles in Rural Kenya Completed NCT01088958 Phase 4
29 Intravenous Treatment of Anemia in Pregnancy Completed NCT03317210 Phase 4 iron sucrose (200 mg VENOFER®);recombinant human erythropoietin (10,000 U EPREX®)
30 Endovenous Versus Liposomal Iron in CKD Completed NCT01864161 Phase 4 gluconate iron;Liposomal iron
31 Short-Term Effects & Safety of an Accelerated Intravenous Iron Regimen in Patients With Heart Failure Completed NCT01925703 Phase 4 Sodium ferric gluconate
32 Effect of Ferrlecit® Versus Oral Iron on Iron Deficient Chronic Kidney Disease (CKD) Patients Completed NCT00224055 Phase 4 Sodium Ferric Gluconate Complex in Sucrose Injection;Ferrous sulfate tablets
33 Effect of Ferrlecit® Versus Oral Iron on Iron Deficient Chronic Kidney Disease (CKD) Patients Receiving Erythropoietic Agents Completed NCT00224042 Phase 4 Sodium Ferric Gluconate complex in sucrose;Ferrous sulfate tablets
34 Effectiveness of Adaptation of the Dose of Iron Supplementation in Pregnancy on Maternal-child Health. (ECLIPSES) Completed NCT03196882 Phase 4 40mg/day of iron;20mg/day of iron;80mg/day of iron
35 Clinical Evaluation of Iron Treatment Efficiency Among Non-anemic But Iron-deficient Female Blood Donors Completed NCT00689793 Phase 4 Ferrous sulphate;Placebo
36 Intravenous Versus Oral Iron in Late Pregnancy: Results of Treatment Completed NCT00746551 Phase 4 Ferli-6® (Continental Pharm co., ltd.);Venofer® (Vifor AG, St. Gallen, Switzerland)
37 Switch From Oral Iron to Intravenous Ferric Carboxymaltose in Non-dialysis Chronic Kidney Disease (CKD) Completed NCT02232906 Phase 4 intravenous ferric carboxymaltose
38 Effect of Two Iron Preparations on Protein in the Urine Completed NCT00354692 Phase 4 Sodium Ferric Gluconate and Iron sucrose
39 DRIVE Trial (Dialysis Patients' Response to Intravenous [IV] Iron With Elevated Ferritin) Completed NCT00224081 Phase 4 Sodium ferric gluconate,
40 Postoperative Vitamin Supplementation in Morbidly Obese Patient (VITAAL Study) Completed NCT01609387 Phase 4
41 Periodic Versus Continuous IV Iron Supplementation in HD Patients Completed NCT02787824 Phase 4 Iron Sucrose Supplement
42 Efficacy of Intravenous Iron Administration in Hemodialysis Patients Completed NCT00298441 Phase 4 chondroitin sulfate-iron colloid
43 The Use of Liposomated Iron After Bariatric Surgery in Patients That Are Receiving Parentheral Therapy With Iron Completed NCT02390921 Phase 4 Fisiogen Ferro Forte;Venofer
44 Prevention of Intrauterine Growth Retardation in Hounde District, Burkina Faso Completed NCT00642408 Phase 4
45 Small Bowel Cleansing Prior to Video Capsule Endoscopy Examination Completed NCT00677794 Phase 4 Clear fluids;Picosalax;Polyethylene glycol
46 Effect of Iron Therapy as an Adjunct to Epoetin Alfa in the Anemia of Cancer Chemotherapy Completed NCT00224068 Phase 4 Sodium ferric gluconate, ferrous sulfate, standard of care
47 Impact of Preoperative Treatment of Anemia and Iron Deficiency in Cardiac Surgery on Outcome. Recruiting NCT02031289 Phase 4 Erythropoietin/Ferric carboxymaltose/Vitamin B12/Folic Acid
48 Iron Treatment for Young Children With Non-anemic Iron Deficiency Recruiting NCT01481766 Phase 4
49 Intravenous Iron Isomaltoside Versus Oral Iron Supplementation for Treatment of Iron Deficiency in Pregnancy. Recruiting NCT03188445 Phase 4 Iron Isomaltoside 1000;ferrous fumarate with ascorbic acid
50 Intravenous Iron in Patients With Systolic Heart Failure and Iron Deficiency to Improve Morbidity & Mortality Recruiting NCT03036462 Phase 4 Iron;Saline

Search NIH Clinical Center for Iron Metabolism Disease

Cochrane evidence based reviews: iron metabolism disorders

Genetic Tests for Iron Metabolism Disease

Anatomical Context for Iron Metabolism Disease

MalaCards organs/tissues related to Iron Metabolism Disease:

38
Lung

Publications for Iron Metabolism Disease

Articles related to Iron Metabolism Disease:

(show top 50) (show all 1226)
# Title Authors Year
1
Pharmacokinetics, pharmacodynamics, safety, and tolerability of intravenous ferric carboxymaltose: a dose-escalation study in Japanese volunteers with iron-deficiency anemia. ( 29357079 )
2018
2
Lactoferrin plus health education versus total dose infusion (TDI) of low-molecular weight (LMW) iron dextran for treating iron deficiency anemia (IDA) in pregnancy: a randomized controlled trial. ( 29338568 )
2018
3
Assessment of peripheral blood lymphocyte subsets in children with iron deficiency anemia. ( 29433459 )
2018
4
Comments on: Prognostic impact of anemia and iron-deficiency anemia in a contemporary cohort of patients undergoing transcatheter aortic valve implantation. ( 29407119 )
2018
5
Should asymptomatic young men with iron deficiency anemia necessarily undergo endoscopy? ( 29294595 )
2018
6
Psychological distress, iron deficiency, active disease and female gender are independent risk factors for fatigue in patients with ulcerative colitis. ( 29435325 )
2018
7
Capsule Endoscopy for Refractory Iron Deficiency Anemia in Crohn's Disease: Captivating Pathology, Hybrid Therapy. ( 29409826 )
2018
8
Association Between Iron-Deficiency Anemia and Hypophosphatemia. ( 29031590 )
2018
9
Relationship between obesity and iron deficiency anemia: is there a role of hepcidin? ( 29318945 )
2018
10
Comparative safety of intravenous ferumoxytol vs ferric carboxymaltose in iron deficiency anemia: A randomized trial. ( 29417614 )
2018
11
Aggregation-Induced Emission Probe for Specific Turn-On Quantification of Soluble Transferrin Receptor: An Important Disease Marker for Iron Deficiency Anemia and Kidney Diseases. ( 29271190 )
2018
12
Oral versus intravenous iron therapy in patients with inflammatory bowel disease and iron deficiency with and without anemia in Germany - a real-world evidence analysis. ( 29440920 )
2018
13
Iron deficiency and iron deficiency anemia in children aged 6-36 months: Is there room for improvement of screening, prophylaxis and treatment? ( 29258914 )
2018
14
Celiac Disease in Children with Moderate-to-Severe Iron-deficiency Anemia. ( 29396932 )
2018
15
Development of probiotic formulation for the treatment of iron deficiency anemia. ( 29353864 )
2018
16
Microcytosis is important in screening of iron deficiency anemia. ( 29361474 )
2018
17
Effectiveness and safety of ferric carboxymaltose compared to iron sucrose in women with iron deficiency anemia: phase IV clinical trials. ( 29304848 )
2018
18
Efficacy and safety of IV ferumoxytol for iron deficiency anemia in patients with cancer. ( 29263710 )
2017
19
Systematic evaluation of paediatric cohort with iron refractory iron deficiency anaemia (IRIDA) phenotype reveals multiple TMPRSS6 gene variations. ( 28169443 )
2017
20
Critical appraisal of discriminant formulas for distinguishing thalassemia from iron deficiency in patients with microcytic anemia. ( 28182576 )
2017
21
Electrophysiological changes of autonomic cells in left ventricular outflow tract in guinea pigs with iron deficiency anemia complicated with chronic heart failure. ( 29268978 )
2017
22
Erythroferrone and iron status parameters levels in pediatric patients with iron deficiency anemia. ( 29282766 )
2017
23
Iron Deficiency Anaemia As Risk Factor For Simple Febrile Seizures: A Case Control Study. ( 28718256 )
2017
24
Comment: Intravenous Ferumoxytol in Pediatric Patients With Iron Deficiency Anemia. ( 28925297 )
2017
25
C-Terminal Fibroblast Growth Factor 23, Iron Deficiency, and Mortality in Renal Transplant Recipients. ( 28774998 )
2017
26
Helicobacter pylori sabA gene is associated with iron deficiency anemia in childhood and adolescence. ( 28854239 )
2017
27
Amino acid chelated iron versus an iron salt in the treatment of iron deficiency anemia with pregnancy: A randomized controlled study. ( 28073037 )
2017
28
Preoperative management of colorectal cancer-induced iron deficiency anemia in clinical practice: data from a large observational cohort. ( 28833205 )
2017
29
Paediatric breath-holding spells are associated with autonomic dysfunction and iron deficiency may play a role. ( 29210110 )
2017
30
Motor hyperactivity of the iron-deficient rat - an animal model of restless legs syndrome. ( 28843017 )
2017
31
Sodium chloride pica causing recurrent nephrolithiasis in a patient with iron deficiency anemia: a case report. ( 29149910 )
2017
32
Idiopathic Pulmonary Hemosiderosis Mimicking Iron Deficiency Anemia: A Delayed Diagnosis? ( 28670434 )
2017
33
A new red cell index and portable RBC analyzer for screening of iron deficiency and Thalassemia minor in a Chinese population. ( 28874768 )
2017
34
A randomized trial of iron isomaltoside versus iron sucrose in patients with iron deficiency anemia. ( 28052413 )
2017
35
VON WILLEBRAND FACTOR IMMUNOHISTOCHEMICAL STAINING QUANTITATIVE OPTICAL DENSITY PARAMETERS IN THE ENDOTHELIUM AND FIBRINOID OF THE PLACENTA DURING SECUNDINES INFLAMMATION AND CONCOMITANT IRON DEFICIENCY ANEMIA IN GRAVIDAS. ( 29328041 )
2017
36
Author's reply: Directly observed iron supplementation for control of iron deficiency anemia. ( 28928309 )
2017
37
The Relationship Between Iron Deficiency Anemia and Sensorineural Hearing Loss in the Pediatric and Adolescent Population. ( 28492865 )
2017
38
Two novel mutations in TMPRSS6 associated with iron-refractory iron deficiency anemia in a mother and child. ( 28460265 )
2017
39
Hepcidin detects iron deficiency in Sri Lankan adolescents with a high burden of hemoglobinopathy: A diagnostic test accuracy study. ( 27883199 )
2017
40
Prevalence of Iron Deficiency and Iron Deficiency Anemia in the Northern and Southern Provinces of Rwanda. ( 28826251 )
2017
41
Challenges in the diagnosis of iron deficiency anemia in aged people. ( 28830594 )
2017
42
Relationship between iron deficiency anemia and febrile seizures in children: A systematic review and meta-analysis. ( 28957722 )
2017
43
Iron deficiency anemia and Plummer-Vinson syndrome: current insights. ( 29089792 )
2017
44
The DMT1 IVS4+44C>A polymorphism and the risk of iron deficiency anemia in children with celiac disease. ( 29023457 )
2017
45
Comparison of Methods Study between a Photonic Crystal Biosensor and Certified ELISA to Measure Biomarkers of Iron Deficiency in Chronic Kidney Disease Patients. ( 28946680 )
2017
46
Phase III randomized trial comparing intravenous to oral iron in patients with cancer-related iron deficiency anemia not on erythropoiesis stimulating agents. ( 28849623 )
2017
47
Assessment of the Matos & Carvalho index for distinguishing thalassemia from iron deficiency anemia. ( 28830614 )
2017
48
A budget impact analysis of parenteral iron treatments for iron deficiency anemia in the UK: reduced resource utilization with iron isomaltoside 1000. ( 28848355 )
2017
49
Effects of Ferric Citrate in Patients with Nondialysis-Dependent CKD and Iron Deficiency Anemia. ( 28082519 )
2017
50
New Bioinformatics-Based Discrimination Formulas for Differentiation of Thalassemia Traits From Iron Deficiency Anemia. ( 28934514 )
2017

Variations for Iron Metabolism Disease

Expression for Iron Metabolism Disease

Search GEO for disease gene expression data for Iron Metabolism Disease.

Pathways for Iron Metabolism Disease

Pathways related to Iron Metabolism Disease according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.04 CP CYBRD1 SLC11A2 SLC40A1 TF TFRC
2
Show member pathways
12.08 CP CYBRD1 SLC11A2 SLC40A1 TF TFRC
3 11.63 EPO TF TFRC
4
Show member pathways
11.56 CP SLC11A2 SLC40A1
5 11.44 CP EPO TF TFRC
6 11.27 CYBRD1 SLC11A2 SLC40A1 TF
7 11.18 EPO TF
8 11.01 EPO SLC11A2
9 10.96 CP SLC11A2 SLC40A1 TF TFRC
10 10.21 HFE HFE2
11 10.18 IREB2 SLC11A2 SLC40A1 TF TFR2 TFRC

GO Terms for Iron Metabolism Disease

Cellular components related to Iron Metabolism Disease according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.92 HFE SLC11A2 SLC40A1 TFR2 TFRC
2 extracellular space GO:0005615 9.88 CP EPO HFE HFE2 TF TFRC
3 perinuclear region of cytoplasm GO:0048471 9.78 HFE SLC11A2 TF TFRC
4 cytoplasmic vesicle GO:0031410 9.77 HFE SLC11A2 TF TFR2 TFRC
5 external side of plasma membrane GO:0009897 9.67 HFE TFR2 TFRC
6 cell surface GO:0009986 9.65 EPO HFE2 SLC11A2 TF TFRC
7 endosome membrane GO:0010008 9.63 SLC11A2 TF TFRC
8 early endosome GO:0005769 9.62 HFE SLC11A2 TF TFRC
9 blood microparticle GO:0072562 9.61 CP TF TFRC
10 extracellular vesicle GO:1903561 9.55 SLC11A2 TFRC
11 brush border membrane GO:0031526 9.54 CYBRD1 SLC11A2
12 clathrin-coated vesicle membrane GO:0030665 9.51 TF TFRC
13 recycling endosome GO:0055037 9.46 HFE SLC11A2 TF TFRC
14 basal part of cell GO:0045178 9.13 HFE SLC11A2 TF
15 HFE-transferrin receptor complex GO:1990712 9.02 HFE HFE2 TF TFR2 TFRC

Biological processes related to Iron Metabolism Disease according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.89 CP HFE SLC11A2 SLC40A1 TF
2 cellular iron ion homeostasis GO:0006879 9.65 CP CYBRD1 HFE HFE2 IREB2 SLC11A2
3 acute-phase response GO:0006953 9.63 EPO HFE TFR2
4 transferrin transport GO:0033572 9.62 HFE TF TFR2 TFRC
5 multicellular organismal iron ion homeostasis GO:0060586 9.58 HFE SLC11A2 SLC40A1
6 response to iron ion GO:0010039 9.56 CYBRD1 HFE SLC11A2 TFR2
7 osteoclast differentiation GO:0030316 9.55 IREB2 TFRC
8 iron ion transport GO:0006826 9.55 IREB2 SLC11A2 SLC40A1 TF TFR2
9 positive regulation of receptor-mediated endocytosis GO:0048260 9.54 HFE TF
10 cellular response to iron ion GO:0071281 9.54 HFE TF TFR2
11 copper ion transport GO:0006825 9.52 CP SLC11A2
12 positive regulation of peptide hormone secretion GO:0090277 9.51 HFE TFR2
13 iron ion transmembrane transport GO:0034755 9.48 SLC11A2 SLC40A1
14 ferrous iron import across plasma membrane GO:0098707 9.43 TF TFR2
15 iron ion homeostasis GO:0055072 9.17 HFE HFE2 IREB2 SLC11A2 SLC40A1 TF

Molecular functions related to Iron Metabolism Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 co-receptor binding GO:0039706 9.37 HFE TFR2
2 iron ion transmembrane transporter activity GO:0005381 9.32 SLC11A2 SLC40A1
3 ferrous iron transmembrane transporter activity GO:0015093 9.26 SLC11A2 SLC40A1
4 transferrin transmembrane transporter activity GO:0033570 9.16 TFR2 TFRC
5 transferrin receptor activity GO:0004998 8.96 TFR2 TFRC
6 transferrin receptor binding GO:1990459 8.8 HFE HFE2 TF

Sources for Iron Metabolism Disease

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