MCID: IRN002
MIFTS: 42

Iron Metabolism Disease

Categories: Immune diseases, Blood diseases, Metabolic diseases

Aliases & Classifications for Iron Metabolism Disease

Summaries for Iron Metabolism Disease

MedlinePlus : 41 iron is a mineral that our bodies need for many functions. for example, iron is part of hemoglobin, a protein which carries oxygen from our lungs throughout our bodies. it helps our muscles store and use oxygen. iron is also part of many other proteins and enzymes. your body needs the right amount of iron. if you have too little iron, you may develop iron deficiency anemia. causes of low iron levels include blood loss, poor diet, or an inability to absorb enough iron from foods. people at higher risk of having too little iron are young children and women who are pregnant or have periods. too much iron can damage your body. taking too many iron supplements can cause iron poisoning. some people have an inherited disease called hemochromatosis. it causes too much iron to build up in the body. centers for disease control and prevention

MalaCards based summary : Iron Metabolism Disease, also known as iron metabolism disorders, is related to iron-refractory iron deficiency anemia and iron deficiency anemia. An important gene associated with Iron Metabolism Disease is TF (Transferrin), and among its related pathways/superpathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Insulin receptor recycling. The drugs Iron and Deferasirox have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and liver, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 72 Human iron metabolism is the set of chemical reactions maintaining human homeostasis of iron at both the... more...

Related Diseases for Iron Metabolism Disease

Diseases related to Iron Metabolism Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 68)
id Related Disease Score Top Affiliating Genes
1 iron-refractory iron deficiency anemia 12.5
2 iron deficiency anemia 12.4
3 hemochromatosis 11.4
4 plummer vinson syndrome 11.3
5 autoimmune atrophic gastritis 11.2
6 hemochromatosis, type 5 11.1
7 hemochromatosis, type 4 11.1
8 hemochromatosis, type 3 11.1
9 microcytic anemia 11.1
10 atrophic gastritis 11.1
11 ancylostomiasis 11.0
12 hiatus hernia 11.0
13 gastric antral vascular ectasia 11.0
14 deficiency anemia 10.9
15 cerebellar ataxia 10.8
16 hemosiderosis 10.8
17 pulmonary arterio-veinous fistula 10.7
18 mucolipidosis iv 10.7
19 dyserythropoietic anemia, congenital, type iii 10.7
20 dermatoosteolysis, kirghizian type 10.5 HFE TF
21 distal arthrogryposis 10.4 SLC11A2 TF
22 posterior foramen magnum meningioma 10.4 TF TFRC
23 thalassemia 10.3
24 cerebral sarcoidosis 10.2 EPO TF
25 tinf2-related dyskeratosis congenita 10.2 HFE TF TFRC
26 klippel-feil syndrome 4, autosomal recessive, with myopathy and facial dysmorphism 10.2 EPO HFE2
27 breast osteosarcoma 10.2 HFE TFRC
28 conjunctival vascular disease 10.2 EPO TFRC
29 microcephaly 8, primary, autosomal recessive 10.2 EPO TF
30 anemia, hypochromic microcytic, with iron overload 1 10.1
31 thalassemia minor 10.1
32 inflammatory bowel disease 10.1
33 thrombocytosis 10.1
34 methylmalonic aciduria and homocystinuria type cblg 10.1 EPO TF
35 celiac disease 10.1
36 gastritis 10.1
37 harp syndrome 10.0 HFE IREB2 TF
38 poems syndrome 10.0 EPO TF TFRC
39 endometrial adenocarcinoma 10.0 EPO HFE TF
40 pyruvate kinase deficiency 10.0 EPO HFE
41 kidney disease 10.0
42 asperger syndrome 10.0 SLC11A2 TFRC
43 anemia, sideroblastic, 1 10.0
44 thrombosis 10.0
45 lacrimal system cancer 10.0 EPO TF TFRC
46 diarrhea 1, secretory chloride, congenital 10.0 HFE TFR2
47 porphyria cutanea tarda 9.9 HFE HFE2 TF TFRC
48 ehlers-danlos syndrome, type iv 9.8 SLC40A1 TFR2
49 slate pneumoconiosis 9.8 HFE SLC40A1 TF TFRC
50 timothy syndrome type 2 9.7 EPO HFE TF TFRC

Comorbidity relations with Iron Metabolism Disease via Phenotypic Disease Network (PDN):


Deficiency Anemia Pulmonary Hemosiderosis

Graphical network of the top 20 diseases related to Iron Metabolism Disease:



Diseases related to Iron Metabolism Disease

Symptoms & Phenotypes for Iron Metabolism Disease

MGI Mouse Phenotypes related to Iron Metabolism Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.02 EPO HFE HFE2 IREB2 SLC11A2 SLC40A1
2 homeostasis/metabolism MP:0005376 10.02 CYBRD1 EPO HFE HFE2 IREB2 SLC11A2
3 cardiovascular system MP:0005385 9.95 CYBRD1 EPO HFE2 IREB2 SLC11A2 SLC40A1
4 immune system MP:0005387 9.86 SLC11A2 SLC40A1 TFR2 TFRC EPO HFE
5 integument MP:0010771 9.63 EPO HFE2 IREB2 SLC11A2 SLC40A1 TFRC
6 liver/biliary system MP:0005370 9.61 IREB2 SLC11A2 SLC40A1 TFR2 TFRC CYBRD1
7 mortality/aging MP:0010768 9.23 TFRC EPO HFE HFE2 IREB2 SLC11A2

Drugs & Therapeutics for Iron Metabolism Disease

Drugs for Iron Metabolism Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 239)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 7439-89-6 23925
2
Deferasirox Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 201530-41-8 5493381
3
Zinc Approved Phase 4,Phase 3,Phase 1 7440-66-6 32051 23994
4
Deferiprone Approved Phase 4,Phase 2,Phase 3,Phase 1 30652-11-0 2972
5
Deferoxamine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 70-51-9 2973
6
Copper Approved Phase 4,Phase 1 7440-50-8 27099
7
Hydroxocobalamin Approved Phase 4,Phase 2,Phase 3 13422-51-0 11953898 5460373 44475014
8
Halofantrine Approved Phase 4 69756-53-2 37393
9
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 1 22916-47-8 4189
10
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 59-30-3 6037
11
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2 58-05-9 143 6006
12
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 11103-57-4, 68-26-8 445354
13
Vitamin C Approved, Nutraceutical Phase 4,Phase 3,Phase 2 50-81-7 5785 54670067
14
Cholecalciferol Approved, Nutraceutical Phase 4 67-97-0 6221 10883523 5280795
15
Cyanocobalamin Approved, Nutraceutical Phase 4,Phase 2,Phase 3 68-19-9 44176380
16
Niacin Approved, Investigational, Nutraceutical Phase 4 59-67-6 938
17
Nicotinamide Approved, Nutraceutical Phase 4 98-92-0 936
18
Pyridoxal Approved, Nutraceutical Phase 4,Phase 2 66-72-8 1050
19
Pyridoxine Approved, Nutraceutical, Vet_approved Phase 4,Phase 2 65-23-6 1054
20
Riboflavin Approved, Nutraceutical, Vet_approved Phase 4 83-88-5 493570
21
Thiamine Approved, Nutraceutical, Vet_approved Phase 4 59-43-8 1130
22 Tocopherol Approved, Nutraceutical Phase 4,Phase 1
23
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Early Phase 1 1406-16-2
24
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4,Phase 1 59-02-9 14985
25
Ergocalciferol Approved, Nutraceutical Phase 4,Early Phase 1 50-14-6 5280793
26
Iodine Investigational Phase 4 7553-56-2 807
27 Micronutrients Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
28 Trace Elements Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
29 Ferric Compounds Phase 4,Phase 3,Phase 2,Phase 1
30 Hematinics Phase 4,Phase 3,Phase 2,Phase 1
31 Teferrol Phase 4
32 Ferrous gluconate Phase 4
33 Ferric oxide, saccharated Phase 4,Phase 3,Phase 2,Phase 1
34 Chelating Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
35 Iron Chelating Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
36 Antioxidants Phase 4,Phase 2,Phase 3,Phase 1
37 Epoetin alfa Phase 4,Phase 3,Phase 2,Phase 1 113427-24-0
38 Protective Agents Phase 4,Phase 2,Phase 3,Phase 1
39 Vitamins Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
40 ferric gluconate Phase 4,Phase 2,Phase 3,Phase 1
41 Retinol palmitate Phase 4,Phase 3,Phase 2
42 Vitamin B Complex Phase 4,Phase 3,Phase 2
43 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1
44 Liver Extracts Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
45 Anticoagulants Phase 4,Phase 3,Phase 2,Phase 1
46 Blood Substitutes Phase 4,Phase 3,Phase 2,Phase 1
47 Dextrans Phase 4,Phase 3,Phase 2,Phase 1
48 Iron-Dextran Complex Phase 4,Phase 3,Phase 2,Phase 1
49 Plasma Substitutes Phase 4,Phase 3,Phase 2,Phase 1
50 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 459)

id Name Status NCT ID Phase Drugs
1 Study Effects of Ginkgo Biloba Extract on Endothelial Cell Function and Genetic Effects on the Response to Ginkgo Biloba Extract in Diabetic Patients With Stable Coronary Artery Disease Unknown status NCT01038050 Phase 4 Ginkgo Biloba Extract (GBE)
2 Iron Supplementation of Marginally Low Birth Weight Infants Unknown status NCT00558454 Phase 4 Iron
3 Different Iron Supplements for Prevention of Anemia in Pregnancy Unknown status NCT02487719 Phase 4 Iron sulfate and Iron polymaltose for prevention of iron deficiency anemia
4 Treatment of Anemia in the 2nd Year of Life. Comparison of the Efficacy of Two Different Iron Preparations. Unknown status NCT00248716 Phase 4 Ferrous gluconate and iron polysaccharide complex
5 Capsule Endoscopy vs Standard of Care for Obscure Intestinal Bleeding Unknown status NCT00694954 Phase 4
6 Iron Therapy in Colo-Rectal Neoplasm and Iron Deficiency Anemia: Intravenous Iron Sucrose Versus Oral Ferrous Sulphate. Unknown status NCT00199277 Phase 4 i.v. iron sucrose;Oral iron
7 Prevention of Iron Deficiency in 2nd Year of Life Unknown status NCT00479102 Phase 4 Ferripel-3 - iron polysaccharide complex for prevention
8 Treatment of Iron Deficiency Anaemia in Inflammatory Bowel Disease With Ferrous Sulphate Completed NCT01991314 Phase 4 Ferrous sulphate
9 Open-Label Single-Arm Pilot Study in Adult Allogeneic Hematopoietic Stem Cell Transplant Recipients With Transfusional Iron Overload Completed NCT01335035 Phase 4 deferasirox
10 Assessment of the Effect of Vitamin C on Anemia in Patients With Continuous Ambulatory Peritoneal Dialysis Completed NCT02780505 Phase 4 vitamin c;placebo
11 Effect of Ferrlecit® Versus Oral Iron on Iron Deficient Chronic Kidney Disease (CKD) Patients Completed NCT00224055 Phase 4 Sodium Ferric Gluconate Complex in Sucrose Injection;Ferrous sulfate tablets
12 Effect of Ferrlecit® Versus Oral Iron on Iron Deficient Chronic Kidney Disease (CKD) Patients Receiving Erythropoietic Agents Completed NCT00224042 Phase 4 Sodium Ferric Gluconate complex in sucrose;Ferrous sulfate tablets
13 Effectiveness of Selling Micronutrient Sprinkles in Rural Kenya Completed NCT01088958 Phase 4
14 Intensive Combined Chelation Therapy for Iron-Induced Cardiac Disease in Patients With Thalassemia Major Completed NCT00800761 Phase 4 Deferoxamine and Deferiprone;Deferoxamine
15 Ferumoxytol for Iron-Deficiency Anemia in Chronic Kidney Disease and Peritoneal Dialysis Patients Completed NCT01942460 Phase 4 Ferumoxytol
16 A Trial of Iron Replacement in Patients With Iron Deficiency. Completed NCT01067547 Phase 4 Iron Sucrose.;Iron sucrose
17 Switch From Oral Iron to Intravenous Ferric Carboxymaltose in Non-dialysis Chronic Kidney Disease (CKD) Completed NCT02232906 Phase 4 intravenous ferric carboxymaltose
18 Endovenous Versus Liposomal Iron in CKD Completed NCT01864161 Phase 4 gluconate iron;Liposomal iron
19 Hospitalization & Mortality in Patients With Iron Deficiency CKD and HF Treated With i.v. Iron. Completed NCT02392910 Phase 4 Iron Sucrose;Placebo
20 Effect of Two Iron Preparations on Protein in the Urine Completed NCT00354692 Phase 4 Sodium Ferric Gluconate and Iron sucrose
21 Pilot Study for Patients With Poor Response to Deferasirox Completed NCT00749515 Phase 4 Deferoxamine;Deferasirox
22 A Study to Compare the Use of Ferric Carboxymaltose With Placebo in Patients With Chronic Heart Failure and Iron Deficiency Completed NCT01453608 Phase 4 Ferinject (ferric carboxymaltose);Placebo (saline)
23 Efficacy and Safety of Oral Deferasirox (20 mg/kg/d) in Pts 3 to 6 Months After Allogeneic Hematopoietic Cell Transplantation Who Present With Iron Overload Completed NCT00654589 Phase 4 Deferasirox
24 Comparison of NovaFerrum® vs Ferrous Sulfate Treatment in Young Children With Nutritional Iron Deficiency Anemia Completed NCT01904864 Phase 4 elemental iron (NovaFerrum®);elemental iron (Ferrous Sulfate)
25 ENTRUST, a 5 Year Surveillance of Children Aged 2 to <6 Years With Transfusional Iron Overload Treated With Deferasirox Completed NCT00466063 Phase 4 Deferasirox
26 Pilot Study of Ferric Carboxymaltose to Treat Iron Deficiency in Asians With Heart Failure Completed NCT01922479 Phase 4 Ferric Carboxymaltose;Placebo
27 Short-Term Effects & Safety of an Accelerated Intravenous Iron Regimen in Patients With Heart Failure Completed NCT01925703 Phase 4 Sodium ferric gluconate
28 Clinical Evaluation of Iron Treatment Efficiency Among Non-anemic But Iron-deficient Female Blood Donors Completed NCT00689793 Phase 4 Ferrous sulphate;Placebo
29 Iron Supplementation Using Total Dose Infusion and Oral Routes for Treatment of Iron Deficiency Anemia in Pregnancy Completed NCT02086838 Phase 4 Theragran Hematinic;low molecular weight iron dextran
30 Efficacy and Safety Study of Iron Sucrose and Oral Iron Acetyl-transferrin Hydroglycerin Completed NCT00802139 Phase 4 venoferrum(iron sucrose);Bolgre (Iron acetyl-transferase)
31 Palatability and Tolerability of Deferasirox Taken With Meals, With Different Liquids or Crushed and Added to Food Completed NCT00845871 Phase 4 deferasirox:
32 Bovine Lactoferrin to Prevent and Cure Iron Deficiency and Iron Deficiency Anemia in Complicated Pregnancies Completed NCT01221844 Phase 4 FerroGrad by Abbott
33 Safety and Efficacy of Desferasirox in Chinese Patients With Iron Overload and Aplastic Anemia Completed NCT01546415 Phase 4 Desferasirox
34 Safety and Efficacy of Exjade in the Treatment of Transfusion-dependent Iron Overload in Aplastic Anemia Patients Completed NCT01818726 Phase 4 ICL670A and standard immunosupressive therapy (Cyclosporine A);Immunosupressive therapy (Cyclosporine A)
35 Intravenous Versus Oral Iron in Late Pregnancy: Results of Treatment Completed NCT00746551 Phase 4 Ferli-6® (Continental Pharm co., ltd.);Venofer® (Vifor AG, St. Gallen, Switzerland)
36 Prevention of Iron Deficiency in Breastfed Infants Completed NCT01444261 Phase 4
37 Effect of Intravenous Iron (Ferinject®) on Exercise Capacity and Quality of Life of Stable COPD Patients Recruiting NCT02416778 Phase 4 Ferric carboxymaltose, Ferinject® 50mg Iron/ml Solution for Injection / Infusion
38 Efficacy and Safety of Ferriprox® in Patients With Sickle Cell Disease or Other Anemias Recruiting NCT02041299 Phase 4 Deferiprone;Deferoxamine
39 Trial of Captafer® vs. Oral Iron Sulfate in the Treatment of Iron Deficiency Anemia in Patients With IBD Recruiting NCT02774057 Phase 4 Captafer®;Iron Sulfate
40 KRX-0502 (Ferric Citrate) in Subjects With NDD-CKD and IDA (The COMPASS Trial) Recruiting NCT03236246 Phase 4 KRX-0502
41 A Double Blind Randomised Placebo-controlled Trial to Assess the Role of Iron Repletion in Glucose Homeostasis. Recruiting NCT03191201 Phase 4 Ferric Carboxymaltose;0.9% sodium chloride solution
42 A Study of Ferric Citrate to Improve Inflammation and Lipid Levels Recruiting NCT02661295 Phase 4 Ferric Citrate
43 Bovine Lactoferrin Versus Ferrous Sulphate In The Treatment Of Iron Deficiency Anemia During Pregnancy Recruiting NCT03202615 Phase 4 F (ferrous sulphate)
44 A Study Comparing the Iron Substitution With the Medicinal Products Ferinject or Monofer Recruiting NCT02905539 Phase 4 Iron Isomaltoside 1000;Ferric Carboxymaltose
45 Impact of Preoperative Treatment of Anemia and Iron Deficiency in Cardiac Surgery on Outcome. Recruiting NCT02031289 Phase 4 Erythropoietin/Ferric carboxymaltose/Vitamin B12/Folic Acid
46 the Efficacy and Safety of Vitamin C for Iron Supplementation in Adult IDA Patients Recruiting NCT02631668 Phase 4 ferrous succinate and vitamin C;ferrous succinate;ferrous succinate
47 to Assess the Effect of Early vs Routine Iron Supplementation on Iron Store and Growth in Term Infants Recruiting NCT03171324 Phase 4 Iron Supplement
48 Supplementing Iron and Development in Breastfed Infants (SIDBI Study) Recruiting NCT02242188 Phase 4 Iron
49 Iron Treatment for Young Children With Non-anemic Iron Deficiency Recruiting NCT01481766 Phase 4
50 A Phase IV Trial of Repeated Doses of Ferumoxytol Compared to Iron Sucrose for the Treatment of Iron Deficiency Anemia in Patients With Chronic Kidney Disease on Hemodialysis Active, not recruiting NCT01227616 Phase 4 Ferumoxytol;Iron Sucrose

Search NIH Clinical Center for Iron Metabolism Disease

Cochrane evidence based reviews: iron metabolism disorders

Genetic Tests for Iron Metabolism Disease

Anatomical Context for Iron Metabolism Disease

MalaCards organs/tissues related to Iron Metabolism Disease:

39
Kidney, Heart, Liver, Lung, Bone, Testes, Brain

Publications for Iron Metabolism Disease

Variations for Iron Metabolism Disease

Expression for Iron Metabolism Disease

Search GEO for disease gene expression data for Iron Metabolism Disease.

Pathways for Iron Metabolism Disease

Pathways related to Iron Metabolism Disease according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.98 CYBRD1 SLC11A2 SLC40A1 TF TFRC
2
Show member pathways
12.1 CYBRD1 SLC11A2 SLC40A1 TF TFRC
3 11.58 EPO TF TFRC
4 11.31 EPO TF TFRC
5 11.16 EPO TF
6 11.16 CYBRD1 SLC11A2 SLC40A1 TF
7 10.96 EPO SLC11A2
8 10.86 SLC11A2 SLC40A1 TF TFRC
9 10.21 HFE HFE2
10 10.18 IREB2 SLC11A2 SLC40A1 TF TFR2 TFRC

GO Terms for Iron Metabolism Disease

Cellular components related to Iron Metabolism Disease according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.85 HFE SLC11A2 SLC40A1 TFR2 TFRC
2 cytoplasmic vesicle GO:0031410 9.72 HFE SLC11A2 TF TFR2 TFRC
3 perinuclear region of cytoplasm GO:0048471 9.71 HFE SLC11A2 TF TFRC
4 external side of plasma membrane GO:0009897 9.65 HFE TFR2 TFRC
5 cell surface GO:0009986 9.65 EPO HFE2 SLC11A2 TF TFRC
6 early endosome GO:0005769 9.61 HFE SLC11A2 TF
7 endosome membrane GO:0010008 9.54 SLC11A2 TF TFRC
8 brush border membrane GO:0031526 9.51 CYBRD1 SLC11A2
9 clathrin-coated vesicle membrane GO:0030665 9.49 TF TFRC
10 recycling endosome GO:0055037 9.46 HFE SLC11A2 TF TFRC
11 basal part of cell GO:0045178 9.13 HFE SLC11A2 TF
12 HFE-transferrin receptor complex GO:1990712 9.02 HFE HFE2 TF TFR2 TFRC

Biological processes related to Iron Metabolism Disease according to GeneCards Suite gene sharing:

(show all 14)
id Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.84 HFE SLC11A2 SLC40A1 TF
2 acute-phase response GO:0006953 9.63 EPO HFE TFR2
3 transferrin transport GO:0033572 9.62 HFE TF TFR2 TFRC
4 cellular iron ion homeostasis GO:0006879 9.61 CYBRD1 HFE HFE2 IREB2 SLC11A2 SLC40A1
5 multicellular organismal iron ion homeostasis GO:0060586 9.58 HFE SLC11A2 SLC40A1
6 response to iron ion GO:0010039 9.56 CYBRD1 HFE SLC11A2 TFR2
7 iron ion transport GO:0006826 9.55 IREB2 SLC11A2 SLC40A1 TF TFR2
8 cellular response to iron ion GO:0071281 9.54 HFE TF TFR2
9 osteoclast differentiation GO:0030316 9.52 IREB2 TFRC
10 positive regulation of receptor-mediated endocytosis GO:0048260 9.51 HFE TF
11 positive regulation of peptide hormone secretion GO:0090277 9.49 HFE TFR2
12 iron ion transmembrane transport GO:0034755 9.48 SLC11A2 SLC40A1
13 ferrous iron import across plasma membrane GO:0098707 9.43 TF TFR2
14 iron ion homeostasis GO:0055072 9.17 HFE HFE2 IREB2 SLC11A2 SLC40A1 TF

Molecular functions related to Iron Metabolism Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 co-receptor binding GO:0039706 9.32 HFE TFR2
2 iron ion transmembrane transporter activity GO:0005381 9.26 SLC11A2 SLC40A1
3 ferrous iron transmembrane transporter activity GO:0015093 9.16 SLC11A2 SLC40A1
4 transferrin receptor activity GO:0004998 8.96 TFR2 TFRC
5 transferrin receptor binding GO:1990459 8.8 HFE HFE2 TF
6 protein binding GO:0005515 10.07 CYBRD1 EPO HFE HFE2 IREB2 SLC11A2

Sources for Iron Metabolism Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
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36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
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43 MESH via Orphanet
44 MGI
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48 NDF-RT
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55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
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67 TGDB
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