Iron Overload malady

Wikipedia: In medicine, iron overload indicates accumulation of iron in the body from any cause. The most important...⁴⁴ more...

MalaCards: Iron Overload is related to hemochromatosis and hepatitis. An important gene associated with Iron Overload is HFE2 (hemochromatosis type 2 (juvenile)), and among its related pathways are Metal ion SLC transporters and Iron uptake and transport. The compounds ferric ammonium citrate and fe3+ have been mentioned in the context of this disorder. Affiliated tissues include brain, skin and liver, and related mouse phenotypes are endocrine/exocrine gland and hematopoietic system.

iron overload 7 32 43

Diseases related to iron overload by text searches and GeneDecks gene sharing:

(show top 50)    (show all 784)

id	Related Disease	Score	Top Affiliating Genes
1	hemochromatosis	38.2	B2M, FXN, IREB2, HLA-B, CYBRD1, ACO1
2	hepatitis	36.7	GPT, IFNA1, SOD2, SLC17A5
3	beta thalassemia	34.1	UGT1A1, B2M, HBA2, HBB, EPO
4	microcytic anemia	33.8	IREB2, ALAS2, GLRX5, TMPRSS6, ACO1, HBA2
5	sideroblastic anemia	33.5	UROD, FXN, FTMT, ALAS2, ABCB7, TFRC
6	alcoholism	33.4	GPT, CYP2E1, ABCB7, TF, SLC17A5, CP
7	hepatitis c	32.2	GPT, IFNA1, F2, HLA-A, TNF, CYP2E1
8	hemoglobinopathy	31.9	HBA2, HBB, HFE, TF, TFRC, EPO
9	aceruloplasminemia	31.8	TF, SOD1, SOD2, CP
10	pyruvate kinase deficiency	31.8	HBA2, HFE, TF, EPO, GDF15
11	hemosiderosis	31.7	FTH1, FTL, CAT, CALCA, HFE, TF
12	hemolytic anemia	31.6	UGT1A1, HPX, HBA2, HBB, HFE, TF
13	hemochromatosis type 2	30.6	HFE, HFE2, TFR2, SLC40A1, HAMP
14	iron metabolism disease	30.5	HFE, TF, TFRC
15	siderosis	30.3	SEC23B, UROD, FTH1, GPT, HMOX1, CYBRD1
16	aminoaciduria	30.2	BCS1L, B2M, ABCB6, SLC7A7
17	congenital hemolytic anemia	30.0	HBB, TF, EPO
18	neonatal hemochromatosis	29.8	FTL, F2, HLA-A
19	liver cirrhosis	29.8	RBP4, SERPINA7, XDH, GPT, IFNA1, F2
20	hypothyroidism	29.1	SERPINA7, IFNA1, CALCA, TG
21	x-linked sideroblastic anemia	28.8	ALAS2, TNF, CRP, ABCB7
22	thalassemia	28.7	NAGLU, VDR, BLMH, BCS1L, CHIT1, UGT1A1
23	alcoholic hepatitis	28.7	F2, TNF, CYP2E1, HGF
24	fatty liver disease	28.4	RBP4, FTH1, FTL, INS, APOB, GPT
25	porphyria cutanea tarda	28.2	BMP6, UROD, FTH1, FTL, GSTM1, IFNA1
26	nonalcoholic steatohepatitis	28.2	BMP6, INS, GPT, F2, ALB, CAT
27	gaucher's disease	28.0	VDR, CHIT1, F5, F2, CAT, TNF
28	adult respiratory distress syndrome	27.9	SELP, F5, TNF, NOS2, TF
29	type 2 diabetes mellitus	27.9	RBP4, SELP, NAGLU, INS, APOB, GPT
30	age related macular degeneration	27.2	GSTM1, IMMT, APOB, F5, F2, CAT
31	retinol binding protein	26.9	RBP4, NAGLU, XDH, B2M, INS, ALB
32	arthropathy	26.8	BMP6, B2M, FTH1, FTL, F2, ALPP
33	cholestasis	26.4	RBP4, BCS1L, GPT, F5, F2, ALB
34	sickle cell disease	26.4	RBP4, SELP, BMP6, UGT1A1, XDH, B2M
35	acute myeloid leukemia	25.5	VDR, BMP6, CHIT1, B2M, GSTM1, GPT
36	macular degeneration	25.2	SELP, GSTM1, IMMT, APOB, F5, F2
37	duodenitis	24.8	VDR, UGT1A1, XDH, B2M, IREB2, INS
38	anemia	24.8	SELP, SERPINA7, SETD2, SEC23B, NAGLU, VDR
39	myeloid leukemia	24.6	SELP, VDR, BMP6, USF2, CHIT1, B2M
40	insulin resistance	24.1	RBP4, SELP, SETD2, NAGLU, VDR, BMP6
41	graft versus host disease	23.9	VDR, BMP6, GSTM1, IFNA1, F5, F2
42	viral hepatitis	23.4	UROD, B2M, INS, GPT, IFNA1, F5
43	hepatocellular carcinoma	21.6	RBP4, SELP, SERPINA7, SETD2, VDR, BMP6
44	esophagitis	20.7	RBP4, SETD2, VDR, BMP6, RAG1, XDH
45	multiple sclerosis	20.3	SELP, VDR, BMP6, CHIT1, XDH, B2M
46	atherosclerosis	19.9	RBP4, SELP, SETD2, VDR, BMP6, CHIT1
47	retinitis	19.7	RBP4, SELP, SETD2, NAGLU, VDR, BMP6
48	cholesterol	19.0	RBP4, SELP, SERPINA7, NAGLU, VDR, BMP6
49	neuronitis	18.5	SELP, SETD2, VDR, BMP6, USF2, PANK2
50	carcinoma	18.5	RBP4, SELP, SERPINA7, SETD2, NAGLU, VDR

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to iron overload:

²²

MGI Mouse Phenotypes related to iron overload:

²⁵ (show all 23)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	10.1	SEC23B, GGT1, SLC22A12, TBPL1, TMPRSS6, XDH
2	hematopoietic system phenotype	MP:0005397	9.5	EPO, HGF, HAMP, SLC11A1, SLC40A1, SLC22A12
3	pigmentation phenotype	MP:0001186	9.4	NAGLU, USF2, APOB, HEPH, CP, GGT1
4	embryogenesis phenotype	MP:0005380	9.3	SLC7A7, F2, SLC40A1, PRL, ABCB7, ODC1
5	renal/urinary system phenotype	MP:0005367	9.2	ESR1, HPX, INS, RAG1, SELP, NAGLU
6	other phenotype	MP:0005395	9.2	HBB, ABCB7, NOS2, NOS1, PTGS2, TMPRSS6
7	liver/biliary system phenotype	MP:0005370	8.9	TMPRSS6, CYBRD1, CYP2E1, ABCB7, HBB, HEPH
8	digestive/alimentary phenotype	MP:0005381	8.4	VDR, SEC23B, SLC40A1, SLC22A12, TFRC, TGFA
9	integument phenotype	MP:0010771	8.0	SELP, RAG1, USF2, BLMH, XDH, F5
10	behavior/neurological phenotype	MP:0005386	7.9	CALCA, CYP2E1, HMOX1, SOD2, F5, GSTM1
11	normal phenotype	MP:0002873	7.8	IREB2, NOS1, HBB, FTMT, HFE, EPO
12	skeleton phenotype	MP:0005390	7.8	SLC39A14, IREB2, BMP6, VDR, INS, NAGLU
13	nervous system phenotype	MP:0003631	7.7	HBB, IREB2, INS, F5, F2, NOS1
14	immune system phenotype	MP:0005387	7.6	SLC11A1, HAMP, GGT1, SLC40A1, CALCR, F2
15	tumorigenesis	MP:0002006	7.4	B2M, RAG1, SLC11A1, CAT, SOD2, PRL
16	reproductive system phenotype	MP:0005389	7.2	SOD2, NEO1, SLC11A2, SLC7A7, PRL, TLR4
17	vision/eye phenotype	MP:0005391	6.9	SELP, NAGLU, RAG1, BFSP1, SLC40A1, PANK2
18	growth/size phenotype	MP:0005378	6.8	MT-CO1, PANK2, USF2, RAG1, BMP6, VDR
19	muscle phenotype	MP:0005369	6.8	SLC7A7, SOD2, SOD1, TGFA, ESR1, TNF
20	mortality/aging	MP:0010768	6.5	TLR4, AHR, HFE2, HFE, HBA2, ACO1
21	cellular phenotype	MP:0005384	5.4	CAT, F2, SOD1, HMOX1, GSTM1, SLPI
22	cardiovascular system phenotype	MP:0005385	4.2	TLR4, AHR, HFE2, HEPH, HBB, ABCB7
23	homeostasis/metabolism phenotype	MP:0005376	2.7	TFR2, TF, TG, TLR4, AHR, HFE2

Articles related to iron overload:

(show top 50)    (show all 322)

id	Title	Authors	Year	Affiliating Genes
1	Sideroblastic anemia, iron overload, and ALAS2 R452S in African-American males: phenotype and genotype features of five unrelated pa tients. (21800356)	Lee P.L.... Barton J.C.	2011	ALAS2
2	Lack of association of primary iron overload and comm on HFE gene mutations with liver cirrhosis in adult Indian population. (21822737)	Jain S.... Choudhuri G.	2011	HFE
3	The role of iron overload and HFE gene mutations in t he era of pegylated interferon and ribavirin treatment of chronic hepatitis C. (20190684)	Sikorska K.... Bielawski K.P.	2010	HFE
4	Anemia, ineffective erythropoiesis, and hepcidin: int eracting factors in abnormal iron metabolism leading to iron overload in I^-thal assemia. (21075282)	Gardenghi S.... Rivella S.	2010	HAMP
5	Hyperferritinemia and iron overload in type 1 Gaucher disease. (20575041)	Stein P.... Mistry P.K.	2010	HFE
6	Nutritional deficiencies in iron overloaded patients with hemoglobinopathies. (19415722)	Claster S.... Coates T.D.	2009	CP
7	Potential nonresponse bias in a clinical examination after initial screening using iron phenotyping and HFE genotyping in the hemoch romatosis and iron overload screening study. (19860558)	Speechley M.... Diaz S.	2009	HFE
8	UGT1A1 gene polymorphism as a potential factor inducing iron overload in the pathogenesis of type 1 hereditary hemochromatosis. (19207584)	Romanowski T.... Bielawski K.P.	2009	UGT1A1
9	Lack of the bone morphogenetic protein BMP6 induces massive iron overload. (19252488)	Meynard D.... Roth M.P.	2009	BMP6
10	Screening for iron overload: Lessons from the HEmochr omatosis and IRon Overload Screening (HEIRS) Study. (19893773)	Adams P.... Eckfeldt J.H.	2009	HFE
11	Study of the eye and lacrimal glands in experimental iron overload in rats in vivo. (18402083)	Repanti M.... Papanastasiou D.A.	2008	TF
12	Early age-of-onset iron overload and homozygosity for the novel hemojuvelin mutation HJV R54X (exon 3; c.160A-->T) in an African American male of West Indies descent. (18492090)	Murugan R.C.... Barton J.C.	2008	TF, HFE2, HAMP
13	Revaluation of clinical and histological criteria for diagnosis of dysmetabolic iron overload syndrome. (18720534)	Riva A.... Piperno A.	2008	TF
14	Characteristics of participants with self-reported hemochromatosis or iron overload at HEIRS study initial screening. (17726683)	Barton J.C.... Dawkins F.W.	2008	HFE2, TFR2, HAMP
15	Accuracy of family history of hemochromatosis or iron overload: the hemochromatosis and iron overload screening study. (18585964)	Acton R.T.... McLaren C.E.	2008	HFE
16	Association of HFE mutations (C282Y and H63D) with iron overload in blood donors from Mexico City. (17297430)	Baptista-Gonzalez H.A.... Mendez-Sanchez N.	2007	HFE
17	Health-related quality of life in a racially diverse population screened for hemochromatosis: results from the Hemochromatosis and Iron Overload Screening (HEIRS) study. (18073584)	Wenzel L.B.... McLaren C.E.	2007	HFE
18	HFE gene mutation, chronic liver disease, and iron overload In Turkey. (17410459)	Yonal O.... Mungan Z.	2007	HFE
19	Chelation therapy for iron overload. (17335681)	Barton J.C.	2007	HFE
20	Iron overload manifesting as apparent exacerbation of hepatic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. (16635785)	Kamble R.T.... George J.N.	2006	TF
21	Disparate phenotypic expression of ALAS2 R452H (nt 1407 G --> A) in two brothers, one with severe sideroblastic anemia and iron overload, hepatic cirrhosis, and hepatocellular carcinoma. (16540354)	Barton J.C.... Lee P.L.	2006	ALAS2, TFR2, SLC40A1
22	Three kinships with ALAS2 P520L (c. 1559 C --> T) mutation, two in association with severe iron overload, and one with sideroblastic anemia and severe iron overload. (16446107)	Lee P.L.... Beutler E.	2006	ALAS2
23	Proteomic analysis of iron overload in human hepatoma cells. (16410366)	Petrak J.... Vyoral D.	2006	ABCC11
24	Survival after liver transplantation in patients with hepatic iron overload: the national hemochromatosis transplant registry. (16083706)	Kowdley K.V.... Polissar N.	2005	HFE
25	The impact of the mutations of the HFE gene and of the SLC11A3 gene on iron overload in Greek thalassemia intermedia and beta(s)/beta(thal) anemia patients. (15075083)	Politou M.... Papanikolaou G.	2004	SLC40A1, HFE
26	Hemochromatosis mutations in the general population: iron overload progression rate. (15070663)	Andersen R.V.... Nordestgaard B.G.	2004	TF, HFE
27	Health implications of iron overload: the role of diet and genotype. (12674437)	Heath A.L.... Fairweather-Tait S.J.	2003	HFE
28	Circadian variations of transferrin saturation levels in iron-overloaded patients: implications for the screening of C282Y-linked haemochromatosis. (12542499)	Guillygomarc'h A.... Deugnier Y.	2003	HFE
29	Hemochromatosis gene (HFE) mutations in South East Asia: a potential for iron overload. (12737949)	Pointon J.J.... Robson K.J.	2003	HFE
30	Relative iron 'overload' in offspring of patients with type 2 diabetes mellitus: a new component in the conundrum of insulin resistance syndrome? (17003017)	Psyrogiannis A.... Vagenakis A.G.	2003	TF, APOB
31	Ferroportin 1 (SCL40A1) variant associated with iron overload in African-Americans. (14636643)	Beutler E.... Vulpe C.	2003	SLC40A1
32	GRACILE syndrome, a lethal metabolic disorder with iron overload, is caused by a point mutation in BCS1L. (12215968)	Visapaeae I.... Peltonen L.	2002	BCS1L, IMMT
33	Mild iron overload in patients carrying the HFE S65C gene mutation: a retrospective study in patients with suspected iron overload and healthy controls. (12377814)	Holmstrom P.... Stal P.	2002	TF, HFE
34	Absence of hepcidin gene mutations in 10 Italian patients with primary iron overload. (11836175)	Majore S.... Grammatico P.	2002	TFR2, HFE, HAMP
35	Serum ceruloplasmin and ferroxidase activity are decreased in HFE C282Y homozygote male iron-overloaded patients. (11804665)	Laine F.... Brissot P.	2002	CP, HFE
36	ABCB6 (MTABC3) excluded as the causative gene for the growth retardation syndrome with aminoaciduria, cholestasis, iron overload, and lactacidosis. (11977179)	Visapaa I.... Peltonen L.	2002	ABCB6
37	HFE mutations do not account for transfusional iron overload in patients with acute myeloid leukemia. (11399828)	Parkkila S.... Koistinen P.	2001	HFE
38	Hepatic iron overload in aceruloplasminaemia. (11076887)	Hellman N.E.... Stremmel W.	2000	CP
39	Iron overload and cancer (10989544)	Blanc J.F.... Balabaud C.	2000	HFE
40	The effect of HFE genotypes on measurements of iron overload in patients attending a health appraisal clinic. (10979877)	Beutler E.... Ho N.	2000	TF, HFE
41	Transferrin receptor 2: continued expression in mouse liver in the face of iron overload and in hereditary hemochromatosis. (10681454)	Fleming R.E.... Sly W.S.	2000	TFRC, TFR2
42	Activation of an iron uptake mechanism from transferr in in hepatocytes by small-molecular-weight iron complexes: implications for th e pathogenesis of iron-overload disease. (9989766)	Richardson D.R.... Baker E.	1999	TF
43	The influence of hemochromatosis mutations on iron overload of thalassemia major. (10477452)	Longo F.... Camaschella C.	1999	HFE
44	Evidence of genetic transmission in African iron overload. (9446671)	Moyo V.M.... Gordeuk V.R.	1998	TF
45	Serum transferrin receptors are decreased in the presence of iron overload. (9550556)	Khumalo H.... Gangaidzo I.T.	1998	TF, TFRC
46	New advances in iron metabolism, iron deficiency, and iron overload. (9371267)	Brittenham G.M.	1994	TFRC, NFE2, C1D
47	Transient iron overload with bleomycin detectable iron in the plasma of patients with adult respiratory distress syndrome. (7520607)	Gutteridge J.M.... Evans T.W.	1994	TF
48	Iron overload in sub-Saharan Africa involves a geneti c component. (1407756)		1992	TF
49	H and L ferritins in myocardium in iron overload. (1951088)	Arbustini E.... Barosi G.	1991	FTL
50	Dietary iron overload in southern African rural blacks. (1975706)	Friedman B.M.... Hamberg S.	1990	GGT1, CRP

Genes related to iron overload according to GeneCards:

(show top 50)    (show all 101)

id	Symbol	Description	Score	GeneCards Section Context
1	HFE2	hemochromatosis type 2 (juvenile)	11.1	Summaries, Publications
2	HAMP	hepcidin antimicrobial peptide	11.1	Summaries, Publications
3	SLC11A2	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	11.1	Summaries, Publications
4	HFE	hemochromatosis	11.0	Publications
5	TF	transferrin	11.0	Publications
6	FTH1	ferritin, heavy polypeptide 1	11.0	Publications
7	SLC40A1	solute carrier family 40 (iron-regulated transporter), member 1	11.0	Publications
8	TFR2	transferrin receptor 2	11.0	Publications
9	BCS1L	BCS1-like (S. cerevisiae)	11.0	Publications
10	ALAS2	aminolevulinate, delta-, synthase 2	11.0	Publications
11	CYBRD1	cytochrome b reductase 1	11.0	UniProt Related, Publications
12	FTL	ferritin, light polypeptide	11.0	Publications
13	FTMT	ferritin mitochondrial	11.0	Publications
14	UROD	uroporphyrinogen decarboxylase	11.0	Publications
15	USF2	upstream transcription factor 2, c-fos interacting	11.0	Publications
16	IREB2	iron-responsive element binding protein 2	11.0	Publications
17	FXN	frataxin	11.0	Publications
18	EPO	erythropoietin	11.0	Publications
19	HEPH	hephaestin	11.0	Publications
20	ACO1	aconitase 1, soluble	11.0	Publications
21	CP	ceruloplasmin (ferroxidase)	11.0	Publications
22	CHIT1	chitinase 1 (chitotriosidase)	11.0
23	GGT1	gamma-glutamyltransferase 1	11.0	Publications
24	TFRC	transferrin receptor (p90, CD71)	11.0	Publications
25	SLC17A5	solute carrier family 17 (anion/sugar transporter), member 5	11.0	Publications
26	SLC11A1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	11.0
27	HBA2	hemoglobin, alpha 2	11.0
28	CYP2E1	cytochrome P450, family 2, subfamily E, polypeptide 1	11.0	Publications
29	HBB	hemoglobin, beta	11.0	Publications
30	SOD2	superoxide dismutase 2, mitochondrial	11.0	Publications
31	HMOX1	heme oxygenase (decycling) 1	11.0	Publications
32	GPT	glutamic-pyruvate transaminase (alanine aminotransferase)	11.0	Publications
33	B2M	beta-2-microglobulin	11.0	Publications
34	CAT	catalase	11.0	Publications
35	SOD1	superoxide dismutase 1, soluble	11.0	Publications
36	GLRX5	glutaredoxin 5	11.0	Publications
37	SLC25A38	solute carrier family 25, member 38	11.0
38	SLC46A1	solute carrier family 46 (folate transporter), member 1	11.0	Publications
39	ABCB6	ATP-binding cassette, sub-family B (MDR/TAP), member 6	11.0	Publications
40	PPOX	protoporphyrinogen oxidase	11.0
41	NDUFA6	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa	11.0
42	HPX	hemopexin	11.0	Publications
43	NFE2	nuclear factor (erythroid-derived 2), 45kDa	11.0	Publications
44	SLC22A12	solute carrier family 22 (organic anion/urate transporter), member 12	11.0	Publications
45	C1D	C1D nuclear receptor corepressor	11.0	Publications
46	TBPL1	TBP-like 1	11.0	Publications
47	PANK2	pantothenate kinase 2	11.0	Publications
48	ATOH8	atonal homolog 8 (Drosophila)	11.0
49	ABCC11	ATP-binding cassette, sub-family C (CFTR/MRP), member 11	11.0	Publications
50	UBE2D1	ubiquitin-conjugating enzyme E2D 1	11.0	Expressions

Pathways related to iron overload according to GeneDecks:

(show all 11)

id	Pathway	Score	Top Affiliating Genes
1	Metal ion SLC transporters38	10.5	HEPH, SLC11A2, SLC40A1, CP
2	Iron uptake and transport38	10.5	FTH1, FTL, CYBRD1
3	Porphyrin and chlorophyll metabolism20	10.4	CP, PPOX, HMOX1, ALAS2, FTL, FTH1
4	Mineral absorption20	10.4	FTH1, HEPH, CYBRD1, HMOX1, TF, SLC11A2
5	Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)41	10.0	NOS1, CP, SOD1, NOS2
6	Doxorubicin Pathway, Pharmacokinetics34	10.0	CAT, XDH, NOS2, SOD1, NOS1
7	Malaria20	9.2	HBA2, HBB, TLR4, HGF, TNF, SELP
8	Selected targets of HNF110	8.8	ALB, CRP, CYP2E1, APOB, INS
9	Immune response IL-1 signaling pathway10	8.6	PTGS2, TNF, HMOX1, NOS2, CP
10	Immune response_IL-1 signaling pathway41	8.4	TNF, CP, NOS2, HMOX1, PTGS2
11	Metabolic pathways20	8.1	XDH, ACO1, NAGLU, CAT, ALPP, ALAS2

Compounds related to iron overload according to GeneDecks:

(show top 50)    (show all 393)

id	Compound	Score	Top Affiliating Genes
1	ferric ammonium citrate32	10.7	TFRC, ACO1, CAT, IREB2, FTMT, FTL
2	fe3+32	10.7	CP, SLC11A2, TFRC, TF, ACO1, CYBRD1
3	protoporphyrin ix32 9 18 9	13.5	ALAS2, FTL, FXN, UROD, HPX, HMOX1
4	fenton32	10.5	XDH, FXN, FTL, CAT, EPO, CP
5	sodium nitroprusside32	10.5	CAT, IREB2, BMP6, HMOX1, ACO1, TF
6	deferoxamine32 9 9	12.2	EPO, CP, SLC40A1, SOD1, TFRC, TFR2
7	phosphorus32	10.0	SLPI, ABCB7, CALCA, ALPP, GPT, B2M
8	phenobarbital32 9 9	11.9	CYP2E1, HMOX1, ALPP, GPT, GSTM1, UGT1A1
9	citrate32	9.9	SELP, NAGLU, SLC11A2, SLPI, SOD2, TFRC
10	pge232	9.8	SETD2, HGF, SLPI, TF, TGFA, TLR4
11	gsno32	9.5	GGT1, SOD1, THPO, ACO1, NOS2, NOS1
12	n acetylcysteine32	9.5	HGF, SLC17A5, TLR4, AHR, ODC1, F2
13	betacarotene32	9.5	SLC17A5, SOD2, SOD1, TFRC, TF, CRP
14	vitamin b1232	9.4	ALPP, ALB, F5, APOB, B2M, TF
15	malondialdehyde32	9.4	HGF, CP, SLC17A5, SLPI, SOD2, SOD1
16	alpha tocopherol32	9.2	GGT1, CP, SOD2, SOD1, TF, ODC1
17	ursodeoxycholic acid32 9 18 9	12.1	HLA-B, HLA-A, ALPP, F2, IFNA1, GPT
18	ascorbic acid32 18	10.1	EPO, SLC17A5, SLC11A2, SLPI, CS, SOD2
19	silymarin32	8.9	F2, GPT, XDH, UGT1A1, BMP6, CAT
20	calcitriol32 42 9 18 9	12.8	EPO, SLPI, SOD2, TFRC, TGFA, TG
21	aspartate32	8.8	GGT1, HGF, SLC11A1, SLC17A5, SOD2, TG
22	dmso32	8.7	NOS1, CYP2E1, ALPP, APOB, XDH, UROD
23	h2o232	8.7	ACO1, NOS1, ODC1, HPX, ALPP, APOB
24	nitric oxide32 9 18 9	11.6	SLC11A1, SLPI, SELP, CS, THPO, TLR4
25	vitamin a32 9 18 9	11.3	ALB, GPT, APOB, GSTM1, B2M, VDR
26	uric acid32 18	9.2	GGT1, CP, NAGLU, RBP4, XDH, B2M
27	thyroxine32 18	9.1	GGT1, CP, SLC17A5, PRL, TF, TG
28	glutamine32	8.1	GGT1, HGF, CP, GPT, APOB, B2M
29	cysteine32	8.1	TGFA, AHR, HBB, ACO1, NOS1, ODC1
30	fibrinogen32	8.0	SLPI, SELP, CHIT1, TF, THPO, TLR4
31	folate32	7.9	EPO, HGF, CP, SLC17A5, SOD2, TFRC
32	vitamin d32	7.8	TLR4, NAGLU, AHR, ESR1, HPX, CALCA
33	arginine32	7.8	CS, INS, XDH, UGT1A1, VDR, SERPINA7
34	testosterone32 9 18 9	10.7	EPO, HGF, SLPI, SOD2, PRL, TFRC
35	pdtc32	7.7	SOD1, TLR4, NOS2, NOS1, PTGS2, TNF
36	creatinine32	7.5	GGT1, EPO, HGF, HAMP, CP, SLC22A12
37	cholesterol32 9 18 9	10.4	UGT1A1, NAGLU, SERPINA7, SELP, RBP4, TLR4
38	tacrolimus32 34 9 9	10.4	TF, NAGLU, TGFA, TLR4, NOS1, TNF
39	tamoxifen32 34 9 9	10.3	GGT1, SLC17A5, SLPI, SOD2, PRL, TF
40	indomethacin32 9 9	9.3	HMOX1, ALB, B2M, UGT1A1, BMP6, TNF
41	vegf32	7.1	ALPP, F5, APOB, SETD2, SELP, CP
42	methotrexate32 34 42 9 9	11.0	GSTM1, BMP6, NAGLU, SLC17A5, SOD2, TF
43	actinomycin d32	6.9	SOD2, TFRC, TGFA, THPO, TLR4, AHR
44	estrogen32	6.8	ODC1, HMOX1, ESR1, CALCA, CALCR, ALPP
45	iron32 18	7.3	SOD2, ABCB6, NDUFA6, NFE2, CRP, PPOX
46	genistein32 9 18 9	9.1	HGF, SLPI, SOD2, TFRC, TGFA, TG
47	cyclosporin a32 42	6.9	HGF, SLC17A5, SLPI, CS, SOD2, TFRC
48	cycloheximide32	5.3	PTGS2, TNF, HMOX1, ESR1, CAT, ALPP
49	dexamethasone32 42 34 9 9	9.1	GGT1, HGF, CP, SLPI, CS, SOD2
50	lactate32	4.4	TG, THPO, TLR4, HBB, ABCB7, CRP

Cellular components related to iron overload according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	basal part of cell	GO:045178	10.2	TF, SLC11A2, HFE
2	phagocytic vesicle membrane	GO:030670	10.0	SLC11A1, HLA-B, HLA-A, B2M
3	MHC class I protein complex	GO:042612	9.9	B2M, HFE, HLA-B, HLA-A
4	integral to plasma membrane	GO:005887	7.9	SLC7A7, SLC39A14, SLC11A2, SLC17A5, SLC40A1, SLC11A1
5	extracellular region	GO:005576	7.0	ALB, SERPINA7, GDF15, HPX, CALCA, F2
6	extracellular space	GO:005615	6.2	CHIT1, HPX, CALCA, ALB, F5, APOB
7	plasma membrane	GO:005886	5.9	SOD1, TFRC, TGFA, TLR4, HFE2, HFE

Biological processes related to iron overload according to GeneDecks:

(show all 25)

id	Name	GO ID	Score	Top Affiliating Genes
1	multicellular organismal iron ion homeostasis	GO:060586	10.8	SLC11A1, SLC40A1, SLC11A2, HFE
2	iron ion transport	GO:006826	10.8	HFE, SLC11A1, TFR2, IREB2, FTMT, FTL
3	heme biosynthetic process	GO:006783	10.7	UROD, FXN, ALAS2, SLC25A38, SLC11A2, PPOX
4	porphyrin-containing compound metabolic process	GO:006778	10.6	PPOX, UROD, UGT1A1, HMOX1, ALAS2
5	cellular iron ion homeostasis	GO:006879	10.4	CYBRD1, TFR2, ACO1, ABCB6, HMOX1, HPX
6	heme transport	GO:015886	10.4	ABCB7, HPX, ABCB6
7	citrate metabolic process	GO:006101	10.3	ACO2, CS, ACO1
8	protoporphyrinogen IX biosynthetic process	GO:006782	10.3	UROD, PPOX, ALAS2
9	iron ion homeostasis	GO:055072	10.1	TMPRSS6, HFE2, SLC11A1, FTL, HMOX1, NEO1
10	defense response to Gram-negative bacterium	GO:050829	10.1	NOS2, TLR4, SLC11A1, SELP
11	positive regulation of vasodilation	GO:045909	10.0	NOS1, HMOX1, CALCA, INS
12	regulation of blood pressure	GO:008217	9.8	SOD2, SOD1, HBB, PTGS2, HMOX1, CALCA
13	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent	GO:002480	9.7	HLA-B, B2M, HLA-A
14	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	9.7	CAT, INS, F2, HGF, SELP
15	embryo implantation	GO:007566	9.6	EPO, SOD1, CALCA, PTGS2
16	transmembrane transport	GO:055085	9.6	SLC7A7, FTH1, ABCB6, ALB, CYBRD1, ABCB7
17	immune response	GO:006955	9.5	BMP6, HAMP, CHIT1, TLR4, FTH1, HFE
18	platelet degranulation	GO:002576	9.5	HGF, TF, ALB, SELP, F5, SOD1
19	response to lipopolysaccharide	GO:032496	9.2	SLC11A1, THPO, TLR4, PTGS2, APOB, UGT1A1
20	platelet activation	GO:030168	9.1	F5, ALB, TF, F2, THPO, HGF
21	response to hypoxia	GO:001666	8.8	CAT, NOS2, CRP, SLC11A2, NOS1, ALAS2
22	response to drug	GO:042493	8.8	FXN, SLC22A12, TNF, B2M, SOD1, TGFA
23	positive regulation of nitric oxide biosynthetic process	GO:045429	8.4	INS, ESR1, TNF, PTGS2, HBB, TLR4
24	blood coagulation	GO:007596	8.2	SLC7A7, THPO, SELP, TF, SOD1, HBB
25	small molecule metabolic process	GO:044281	7.7	ACO2, GGT1, SLC46A1, CS, HBB, HBA2

Molecular functions related to iron overload according to GeneDecks:

(show all 10)

id	Name	GO ID	Score	Top Affiliating Genes
1	ferric iron binding	GO:008199	10.6	FXN, FTL, FTMT, TF, FTH1
2	ferroxidase activity	GO:004322	10.6	FXN, FTH1, FTMT, CP
3	heme transporter activity	GO:015232	10.3	SLC46A1, ABCB7, ABCB6, HPX
4	oxygen binding	GO:019825	9.9	ALB, HBB, HBA2, CYP2E1
5	iron ion binding	GO:005506	9.9	NOS1, SLC11A2, FTL, HBB, HBA2, ACO2
6	copper ion binding	GO:005507	9.5	F5, CP, ALB, SOD1, SLC11A2, HEPH
7	hormone activity	GO:005179	9.4	PRL, TG, INS, EPO, CALCA, THPO
8	heme binding	GO:020037	9.3	CYP2E1, HBA2, ABCB6, NOS2, NOS1, PTGS2
9	enzyme binding	GO:019899	8.4	CYP2E1, ESR1, SLPI, PTGS2, UGT1A1, APOB
10	protein binding	GO:005515	4.2	HFE, F5, APOB, MDFIC, IMMT, INS