MCID: IRR001
MIFTS: 28

Irregular Astigmatism

Categories: Eye diseases

Aliases & Classifications for Irregular Astigmatism

MalaCards integrated aliases for Irregular Astigmatism:

Name: Irregular Astigmatism 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:13919
ICD10 32 H52.21
ICD9CM 34 367.22
SNOMED-CT 64 47099006
UMLS 69 C0152194

Summaries for Irregular Astigmatism

MalaCards based summary : Irregular Astigmatism is related to keratoconus and keratoconus 1. An important gene associated with Irregular Astigmatism is RPS29 (Ribosomal Protein S29). The drugs Lidocaine and Dipivefrin have been mentioned in the context of this disorder. Affiliated tissues include eye and endothelial.

Related Diseases for Irregular Astigmatism

Diseases related to Irregular Astigmatism via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 14)
# Related Disease Score Top Affiliating Genes
1 keratoconus 11.3
2 keratoconus 1 10.9
3 keratoconus 5 10.9
4 astigmatism 10.8
5 cataract 32, multiple types 10.0
6 cataract 10.0
7 endotheliitis 10.0
8 keratitis, hereditary 9.9
9 glass syndrome 9.9
10 myopia 9.9
11 anisometropia 9.9
12 corneal ectasia 9.9
13 streptococcal group a invasive disease 9.9
14 pierre robin syndrome 9.8 RPS27 RPS29

Graphical network of the top 20 diseases related to Irregular Astigmatism:



Diseases related to Irregular Astigmatism

Symptoms & Phenotypes for Irregular Astigmatism

Drugs & Therapeutics for Irregular Astigmatism

Drugs for Irregular Astigmatism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 2, Phase 3 137-58-6 3676
2
Dipivefrin Approved Phase 3 52365-63-6 3105
3
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 59-30-3 6037
4
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Phase 2, Phase 3 83-88-5 493570
5 Anesthetics Phase 2, Phase 3
6 Anesthetics, Local Phase 2, Phase 3
7 Anti-Arrhythmia Agents Phase 2, Phase 3
8 Central Nervous System Depressants Phase 2, Phase 3
9 Dermatologic Agents Phase 2, Phase 3
10 Dextrans Phase 2, Phase 3
11 Diuretics, Potassium Sparing Phase 2, Phase 3
12
Flavin Mononucleotide Phase 2, Phase 3 146-17-8 643976
13 Micronutrients Phase 2, Phase 3
14 Peripheral Nervous System Agents Phase 2, Phase 3
15 Pharmaceutical Solutions Phase 2, Phase 3
16 Photosensitizing Agents Phase 2, Phase 3
17 Sodium Channel Blockers Phase 2, Phase 3
18 Trace Elements Phase 2, Phase 3
19 Vitamin B Complex Phase 2, Phase 3
20 Vitamins Phase 2, Phase 3
21 Mitomycins Phase 3
22 Ophthalmic Solutions Phase 3
23 Folate Nutraceutical Phase 2, Phase 3
24 Vitamin B2 Nutraceutical Phase 2, Phase 3
25 Vitamin B9 Nutraceutical Phase 2, Phase 3
26 Tetrahydrozoline

Interventional clinical trials:

(show all 13)

# Name Status NCT ID Phase Drugs
1 Treatment of Keratoconus Using Collagen Cross-Linking Unknown status NCT00841386 Phase 2, Phase 3 Riboflavin-5-phosphate;Sham cross-linking
2 Evaluating the Safety and Efficacy of the KXL System for Corneal Collagen Cross-Linking in Eyes Having Keratoconus Unknown status NCT02638376 Phase 3
3 Corneal Cross Linking and Topography Guided Excimer Laser Treatment Terminated NCT01682993 Phase 3
4 Measurement Repeatability in Contemporary Aberrometry Unknown status NCT02687022
5 Biomechanical Properties of Keratoconic Eyes Unknown status NCT02476149
6 Evaluation of Topical Riboflavin Exposed to UVA Radiation and Implantation of Corneal Ring Completed NCT00832897
7 Study of Clinical Performance of Corneal Topography Measurement Using an Optical Biometer Completed NCT01861925
8 Visual Outcomes of Topography Guided Photorefractive Keratectomy (PRK) for Treatment of Patients With Irregular Cornea Recruiting NCT03140046
9 Changes of Visual Function, Ocular Surface Structures and Physiology After Long-Termed Contact Lens Wear Recruiting NCT02894489
10 Higher Irradiance in Keratoconus Ectasia Recruiting NCT01789333 Riboflavin 0.1% ophthalmic solution
11 Scleral Versus Corneal RGP Contact Lenses in Irregular Cornea Disorders Enrolling by invitation NCT02444923
12 Astigmatism in Keratoconus Patients Not yet recruiting NCT03450213
13 Progressive Keratoconus or Ectasia Treatment Plan No longer available NCT01384773

Search NIH Clinical Center for Irregular Astigmatism

Genetic Tests for Irregular Astigmatism

Anatomical Context for Irregular Astigmatism

MalaCards organs/tissues related to Irregular Astigmatism:

38
Eye, Endothelial

Publications for Irregular Astigmatism

Articles related to Irregular Astigmatism:

(show top 50) (show all 83)
# Title Authors Year
1
Visual Outcomes and Aberrometric Changes With Topography-Guided Photorefractive Keratectomy Treatment of Irregular Astigmatism After Penetrating Keratoplasty. ( 29215394 )
2018
2
Role of Hemidivisional Corneal Topographic Astigmatisms (CorTs) in the Regularization and Reduction of Irregular Astigmatism. ( 29135603 )
2018
3
Validity of autorefractor based screening method for irregular astigmatism compared to the corneal topography- a cross sectional study. ( 28944202 )
2017
4
Stepwise Guided Photorefractive Keratectomy in Treatment of Irregular Astigmatism After Penetrating Keratoplasty and Deep Anterior Lamellar Keratoplasty. ( 28914632 )
2017
5
Repair of Irregularly Irregular Astigmatism by Transepithelial Phototherapeutic Keratectomy. ( 28991341 )
2017
6
Effects of corneal irregular astigmatism on visual acuity after conventional and femtosecond laser-assisted Descemet's stripping automated endothelial keratoplasty. ( 26028117 )
2015
7
Irregular Astigmatism After Corneal Transplantation-Efficacy and Safety of Topography-Guided Treatment. ( 26509761 )
2015
8
Stromal surface topography-guided custom ablation as a repair tool for corneal irregular astigmatism. ( 25599543 )
2015
9
Safety and efficacy of femtosecond laser-assisted arcuate keratotomy to treat irregular astigmatism after penetrating keratoplasty. ( 26189378 )
2015
10
Transepithelial phototherapeutic keratectomy protocol for treating irregular astigmatism based on population epithelial thickness measurements by artemis very high-frequency digital ultrasound. ( 24972404 )
2014
11
Topography-guided photorefractive keratectomy for irregular astigmatism after small incision lenticule extraction. ( 24972410 )
2014
12
Visual outcomes of topography-guided excimer laser surgery for treatment of patients with irregular astigmatism. ( 23435799 )
2014
13
Irregular astigmatism after femtosecond laser refractive lenticule extraction. ( 23688883 )
2013
14
Wearing time as a measure of success of scleral lenses for patients with irregular astigmatism. ( 24145901 )
2013
15
Incidence of irregular astigmatism eligible for contact lens fitting after Descemet membrane endothelial keratoplasty. ( 23664354 )
2013
16
Topography-guided transepithelial photorefractive keratectomy for irregular astigmatism using a 213 nm solid-state laser. ( 23158680 )
2013
17
Advanced topography-guided (OcuLink) treatment of irregular astigmatism after epikeratophakia in keratoconus with the WaveLight excimer laser. ( 22094961 )
2012
18
Intrastromal corneal ring segment implantation for irregular astigmatism after laser in situ keratomileusis. ( 22520312 )
2012
19
Customized photorefractive keratectomy for the correction of regular and irregular astigmatism after penetrating keratoplasty. ( 21912229 )
2011
20
Toric soft contact lens fit in a postoperative LASIK keratoectasia patient with high and irregular astigmatism. ( 22019833 )
2011
21
Femtosecond-assisted astigmatic keratotomy for post-keratoplasty irregular astigmatism. ( 19101418 )
2009
22
Severe hyperopic shift and irregular astigmatism after radial keratotomy. ( 19812501 )
2009
23
Recovery of corneal irregular astigmatism, ocular higher-order aberrations, and contrast sensitivity after discontinuation of overnight orthokeratology. ( 19019936 )
2009
24
Management of irregular astigmatism following rotationally disoriented free cap after LASIK. ( 18500089 )
2008
25
Irregular astigmatism after cataract surgery resulting from inadequate clear corneal incision formation. ( 19034136 )
2008
26
Topography-guided ablation for treatment of patients with irregular astigmatism. ( 17326350 )
2007
27
Topographic customized photorefractive keratectomy for regular and irregular astigmatism after penetrating keratoplasty using the LIGI CIPTA/LaserSight platform. ( 17912938 )
2007
28
Longitudinal changes in corneal irregular astigmatism and visual acuity in eyes with keratoconus. ( 17660986 )
2007
29
Phototherapeutic keratectomy for epithelial irregular astigmatism: an emphasis on map-dot-fingerprint degeneration. ( 17269244 )
2007
30
Topography-guided treatment of irregular astigmatism with the wavelight excimer laser. ( 16629063 )
2006
31
Corneal irregular astigmatism after hyperopic laser in situ keratomileusis. ( 16160493 )
2005
32
Strategic planning in topography-guided ablation of irregular astigmatism after laser refractive surgery. ( 16128335 )
2005
33
Corneal regular and irregular astigmatism assessed by Fourier analysis of videokeratography data in normal and pathologic eyes. ( 15051209 )
2004
34
Topographically guided ablations for the correction of irregular astigmatism after corneal surgery. ( 12881654 )
2003
35
Management of irregular astigmatism after laser in situ keratomileusis. ( 12881656 )
2003
36
Treatment of irregular astigmatism and keratoconus with the VISX C-CAP method. ( 12881653 )
2003
37
Intraocular lens calculations in patients with corneal scarring and irregular astigmatism. ( 12900244 )
2003
38
Fourier analysis of induced irregular astigmatism. Photorefractive keratectomy versus laser in situ keratomileusis in a bilateral cohort of hyperopic patients. ( 14522289 )
2003
39
Topography-guided laser in situ keratomileusis (TOPOLINK) to correct irregular astigmatism after previous refractive surgery. ( 14518740 )
2003
40
RGP lens treats irregular astigmatism from intracorneal glass. ( 12861118 )
2003
41
Consultation section. Refractive surgical problem: irregular astigmatism in the left eye. ( 12551660 )
2003
42
Management of irregular astigmatism induced by laser in situ keratomileusis. ( 12881655 )
2003
43
Evaluation of lenticular irregular astigmatism using wavefront analysis in patients with lenticonus. ( 12365924 )
2002
44
Correction of irregular astigmatism. ( 11927414 )
2002
45
Contact lens fitting to correct irregular astigmatism after corneal refractive surgery. ( 12388023 )
2002
46
Soft contact lenses for irregular astigmatism after laser in situ keratomileusis. ( 11758989 )
2001
47
Surgically induced topographical abnormalities after LASIK: management of central islands, corneal ectasia, decentration, and irregular astigmatism. ( 11507346 )
2001
48
Correction of irregular astigmatism with excimer laser assisted by sodium hyaluronate. ( 11425683 )
2001
49
Corneal irregular astigmatism after laser in situ keratomileusis for myopia. ( 11316709 )
2001
50
Corneal irregular astigmatism and contrast sensitivity after photorefractive keratectomy. ( 11733260 )
2001

Variations for Irregular Astigmatism

Expression for Irregular Astigmatism

Search GEO for disease gene expression data for Irregular Astigmatism.

Pathways for Irregular Astigmatism

GO Terms for Irregular Astigmatism

Cellular components related to Irregular Astigmatism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosolic small ribosomal subunit GO:0022627 8.62 RPS27 RPS29

Biological processes related to Irregular Astigmatism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 translational initiation GO:0006413 9.26 RPS27 RPS29
2 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 9.16 RPS27 RPS29
3 viral transcription GO:0019083 8.96 RPS27 RPS29
4 SRP-dependent cotranslational protein targeting to membrane GO:0006614 8.62 RPS27 RPS29

Sources for Irregular Astigmatism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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