MCID: IRR001
MIFTS: 26

Irregular Astigmatism

Categories: Eye diseases

Aliases & Classifications for Irregular Astigmatism

MalaCards integrated aliases for Irregular Astigmatism:

Name: Irregular Astigmatism 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:13919
ICD10 33 H52.21
ICD9CM 35 367.22
SNOMED-CT 64 47099006
UMLS 69 C0152194

Summaries for Irregular Astigmatism

MalaCards based summary : Irregular Astigmatism is related to keratoconus and keratoconus 5. An important gene associated with Irregular Astigmatism is RPS29 (Ribosomal Protein S29). The drugs Lidocaine and Dipivefrin have been mentioned in the context of this disorder. Affiliated tissues include eye and endothelial, and related phenotype is Nucleoplasmic pre-40S maturation defects.

Related Diseases for Irregular Astigmatism

Diseases related to Irregular Astigmatism via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 13)
id Related Disease Score Top Affiliating Genes
1 keratoconus 11.2
2 keratoconus 5 10.8
3 keratoconus 1 10.8
4 astigmatism 10.7
5 clubfoot 10.0 LOXL3 NYX
6 endotheliitis 9.9
7 cataract 9.9
8 myopia 9.8
9 anisometropia 9.8
10 corneal ectasia 9.8
11 keratitis 9.8
12 campomelic dysplasia 9.7 RPS27 RPS29
13 necrotizing ulcerative gingivitis 7.0 CHST6 LOXL3 NYX PRDM5 RPS27 RPS29

Graphical network of the top 20 diseases related to Irregular Astigmatism:



Diseases related to Irregular Astigmatism

Symptoms & Phenotypes for Irregular Astigmatism

GenomeRNAi Phenotypes related to Irregular Astigmatism according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Nucleoplasmic pre-40S maturation defects GR00209-A-1 8.62 RPS27 RPS29

Drugs & Therapeutics for Irregular Astigmatism

Drugs for Irregular Astigmatism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 2, Phase 3 137-58-6 3676
2
Dipivefrin Approved Phase 3 52365-63-6 3105
3
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 59-30-3 6037
4
Riboflavin Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 83-88-5 493570
5
Flavin Mononucleotide Experimental Phase 2, Phase 3 146-17-8 643976
6 Anesthetics Phase 2, Phase 3
7 Anesthetics, Local Phase 2, Phase 3
8 Anti-Arrhythmia Agents Phase 2, Phase 3
9 Central Nervous System Depressants Phase 2, Phase 3
10 Dermatologic Agents Phase 2, Phase 3
11 Dextrans Phase 2, Phase 3
12 Diuretics, Potassium Sparing Phase 2, Phase 3
13 Micronutrients Phase 2, Phase 3
14 Peripheral Nervous System Agents Phase 2, Phase 3
15 Pharmaceutical Solutions Phase 2, Phase 3
16 Photosensitizing Agents Phase 2, Phase 3
17 Sodium Channel Blockers Phase 2, Phase 3
18 Trace Elements Phase 2, Phase 3
19 Vitamin B Complex Phase 2, Phase 3
20 Vitamins Phase 2, Phase 3
21 Ophthalmic Solutions Phase 3
22 Mitomycins Phase 3
23 Folate Nutraceutical Phase 2, Phase 3
24 Vitamin B2 Nutraceutical Phase 2, Phase 3
25 Vitamin B9 Nutraceutical Phase 2, Phase 3
26 Tetrahydrozoline

Interventional clinical trials:

(show all 13)

id Name Status NCT ID Phase Drugs
1 Treatment of Keratoconus Using Collagen Cross-Linking Unknown status NCT00841386 Phase 2, Phase 3 Riboflavin-5-phosphate;Sham cross-linking
2 Evaluating the Safety and Efficacy of the KXL System for Corneal Collagen Cross-Linking in Eyes Having Keratoconus Recruiting NCT02638376 Phase 3
3 Corneal Cross Linking and Topography Guided Excimer Laser Treatment Terminated NCT01682993 Phase 3
4 Biomechanical Properties of Keratoconic Eyes Unknown status NCT02476149
5 Evaluation of Topical Riboflavin Exposed to UVA Radiation and Implantation of Corneal Ring Completed NCT00832897
6 Study of Clinical Performance of Corneal Topography Measurement Using an Optical Biometer Completed NCT01861925
7 Visual Outcomes of Topography Guided Photorefractive Keratectomy (PRK) for Treatment of Patients With Irregular Cornea Recruiting NCT03140046
8 Changes of Visual Function, Ocular Surface Structures and Physiology After Long-Termed Contact Lens Wear Recruiting NCT02894489
9 Higher Irradiance in Keratoconus Ectasia Recruiting NCT01789333 Riboflavin 0.1% ophthalmic solution
10 Study to Evaluate the Safety and Efficacy of HI-BRITE Large Diameter Rigid Gas Permeable Contact Lens Active, not recruiting NCT02812316
11 Scleral Versus Corneal RGP Contact Lenses in Irregular Cornea Disorders Enrolling by invitation NCT02444923
12 Measurement Repeatability in Contemporary Aberrometry Not yet recruiting NCT02687022
13 Progressive Keratoconus or Ectasia Treatment Plan No longer available NCT01384773

Search NIH Clinical Center for Irregular Astigmatism

Genetic Tests for Irregular Astigmatism

Anatomical Context for Irregular Astigmatism

MalaCards organs/tissues related to Irregular Astigmatism:

39
Eye, Endothelial

Publications for Irregular Astigmatism

Articles related to Irregular Astigmatism:

(show top 50) (show all 80)
id Title Authors Year
1
Stepwise Guided Photorefractive Keratectomy in Treatment of Irregular Astigmatism After Penetrating Keratoplasty and Deep Anterior Lamellar Keratoplasty. ( 28914632 )
2017
2
Validity of autorefractor based screening method for irregular astigmatism compared to the corneal topography- a cross sectional study. ( 28944202 )
2017
3
Stromal surface topography-guided custom ablation as a repair tool for corneal irregular astigmatism. ( 25599543 )
2015
4
Safety and efficacy of femtosecond laser-assisted arcuate keratotomy to treat irregular astigmatism after penetrating keratoplasty. ( 26189378 )
2015
5
Effects of corneal irregular astigmatism on visual acuity after conventional and femtosecond laser-assisted Descemet's stripping automated endothelial keratoplasty. ( 26028117 )
2015
6
Irregular Astigmatism After Corneal Transplantation-Efficacy and Safety of Topography-Guided Treatment. ( 26509761 )
2015
7
Topography-guided photorefractive keratectomy for irregular astigmatism after small incision lenticule extraction. ( 24972410 )
2014
8
Transepithelial phototherapeutic keratectomy protocol for treating irregular astigmatism based on population epithelial thickness measurements by artemis very high-frequency digital ultrasound. ( 24972404 )
2014
9
Visual outcomes of topography-guided excimer laser surgery for treatment of patients with irregular astigmatism. ( 23435799 )
2014
10
Topography-guided transepithelial photorefractive keratectomy for irregular astigmatism using a 213 nm solid-state laser. ( 23158680 )
2013
11
Incidence of irregular astigmatism eligible for contact lens fitting after Descemet membrane endothelial keratoplasty. ( 23664354 )
2013
12
Wearing time as a measure of success of scleral lenses for patients with irregular astigmatism. ( 24145901 )
2013
13
Irregular astigmatism after femtosecond laser refractive lenticule extraction. ( 23688883 )
2013
14
Intrastromal corneal ring segment implantation for irregular astigmatism after laser in situ keratomileusis. ( 22520312 )
2012
15
Advanced topography-guided (OcuLink) treatment of irregular astigmatism after epikeratophakia in keratoconus with the WaveLight excimer laser. ( 22094961 )
2012
16
Toric soft contact lens fit in a postoperative LASIK keratoectasia patient with high and irregular astigmatism. ( 22019833 )
2011
17
Customized photorefractive keratectomy for the correction of regular and irregular astigmatism after penetrating keratoplasty. ( 21912229 )
2011
18
Severe hyperopic shift and irregular astigmatism after radial keratotomy. ( 19812501 )
2009
19
Recovery of corneal irregular astigmatism, ocular higher-order aberrations, and contrast sensitivity after discontinuation of overnight orthokeratology. ( 19019936 )
2009
20
Femtosecond-assisted astigmatic keratotomy for post-keratoplasty irregular astigmatism. ( 19101418 )
2009
21
Management of irregular astigmatism following rotationally disoriented free cap after LASIK. ( 18500089 )
2008
22
Irregular astigmatism after cataract surgery resulting from inadequate clear corneal incision formation. ( 19034136 )
2008
23
Phototherapeutic keratectomy for epithelial irregular astigmatism: an emphasis on map-dot-fingerprint degeneration. ( 17269244 )
2007
24
Topographic customized photorefractive keratectomy for regular and irregular astigmatism after penetrating keratoplasty using the LIGI CIPTA/LaserSight platform. ( 17912938 )
2007
25
Topography-guided ablation for treatment of patients with irregular astigmatism. ( 17326350 )
2007
26
Longitudinal changes in corneal irregular astigmatism and visual acuity in eyes with keratoconus. ( 17660986 )
2007
27
Topography-guided treatment of irregular astigmatism with the wavelight excimer laser. ( 16629063 )
2006
28
Strategic planning in topography-guided ablation of irregular astigmatism after laser refractive surgery. ( 16128335 )
2005
29
Corneal irregular astigmatism after hyperopic laser in situ keratomileusis. ( 16160493 )
2005
30
Corneal regular and irregular astigmatism assessed by Fourier analysis of videokeratography data in normal and pathologic eyes. ( 15051209 )
2004
31
Topographically guided ablations for the correction of irregular astigmatism after corneal surgery. ( 12881654 )
2003
32
Consultation section. Refractive surgical problem: irregular astigmatism in the left eye. ( 12551660 )
2003
33
Treatment of irregular astigmatism and keratoconus with the VISX C-CAP method. ( 12881653 )
2003
34
Management of irregular astigmatism after laser in situ keratomileusis. ( 12881656 )
2003
35
Intraocular lens calculations in patients with corneal scarring and irregular astigmatism. ( 12900244 )
2003
36
Topography-guided laser in situ keratomileusis (TOPOLINK) to correct irregular astigmatism after previous refractive surgery. ( 14518740 )
2003
37
RGP lens treats irregular astigmatism from intracorneal glass. ( 12861118 )
2003
38
Management of irregular astigmatism induced by laser in situ keratomileusis. ( 12881655 )
2003
39
Fourier analysis of induced irregular astigmatism. Photorefractive keratectomy versus laser in situ keratomileusis in a bilateral cohort of hyperopic patients. ( 14522289 )
2003
40
Contact lens fitting to correct irregular astigmatism after corneal refractive surgery. ( 12388023 )
2002
41
Evaluation of lenticular irregular astigmatism using wavefront analysis in patients with lenticonus. ( 12365924 )
2002
42
Correction of irregular astigmatism. ( 11927414 )
2002
43
Corneal irregular astigmatism and contrast sensitivity after photorefractive keratectomy. ( 11733260 )
2001
44
Corneal irregular astigmatism after laser in situ keratomileusis for myopia. ( 11316709 )
2001
45
Surgically induced topographical abnormalities after LASIK: management of central islands, corneal ectasia, decentration, and irregular astigmatism. ( 11507346 )
2001
46
Correction of irregular astigmatism with excimer laser assisted by sodium hyaluronate. ( 11425683 )
2001
47
Photorefractive keratectomy with customized segmental ablation to correct irregular astigmatism after laser in situ keratomileusis. ( 11316028 )
2001
48
Soft contact lenses for irregular astigmatism after laser in situ keratomileusis. ( 11758989 )
2001
49
Early clinical experience using custom excimer laser ablations to treat irregular astigmatism. ( 11033389 )
2000
50
Fourier analysis of irregular astigmatism after trabeculectomy. ( 10743918 )
2000

Variations for Irregular Astigmatism

Expression for Irregular Astigmatism

Search GEO for disease gene expression data for Irregular Astigmatism.

Pathways for Irregular Astigmatism

GO Terms for Irregular Astigmatism

Cellular components related to Irregular Astigmatism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytosolic small ribosomal subunit GO:0022627 8.62 RPS27 RPS29

Biological processes related to Irregular Astigmatism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 translational initiation GO:0006413 9.26 RPS27 RPS29
2 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 9.16 RPS27 RPS29
3 viral transcription GO:0019083 8.96 RPS27 RPS29
4 SRP-dependent cotranslational protein targeting to membrane GO:0006614 8.62 RPS27 RPS29

Molecular functions related to Irregular Astigmatism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 structural constituent of ribosome GO:0003735 8.62 RPS27 RPS29

Sources for Irregular Astigmatism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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