IBD
MCID: IRR002
MIFTS: 65

Irritable Bowel Syndrome (IBD) malady

Rare diseases, Gastrointestinal diseases categories
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Summaries for Irritable Bowel Syndrome

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Sources:
8Disease Ontology, 34MedlinePlus, 65Wikipedia, 33MalaCards
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MedlinePlus:34 Irritable bowel syndrome (ibs) is a problem that affects the large intestine. it can cause abdominal cramping, bloating, and a change in bowel habits. some people with the disorder have constipation. some have diarrhea. others go back and forth between the two. although ibs can cause a great deal of discomfort, it does not harm the intestines. ibs is common. it affects about twice as many women as men and is most often found in people younger than 45 years. no one knows the exact cause of ibs. there is no specific test for it. your doctor may run tests to be sure you don't have other diseases. these tests may include stool sampling tests, blood tests, and x-rays. your doctor may also do a test called a sigmoidoscopy or colonoscopy. most people diagnosed with ibs can control their symptoms with diet, stress management, probiotics, and medicine. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Irritable Bowel Syndrome, also known as inflammatory bowel diseases, is related to constipation and dyspepsia. An important gene associated with Irritable Bowel Syndrome is MIR510 (microRNA 510), and among its related pathways are Ligand-gated ion channel transport and Integrin alphaIIb beta3 signaling. The drugs cromolyn sodium and cromolyn and the compounds 1,4-benzodiazepine and asperlicin have been mentioned in the context of this disorder. Affiliated tissues include colon, testes and kidney, and related mouse phenotypes are endocrine/exocrine gland and behavior/neurological.

Disease Ontology:8 A syndrome that is a functional bowel disorder characterized by chronic abdominal pain, discomfort, bloating, and alteration of bowel habits in the absence of any detectable organic cause.

Wikipedia:65 Irritable bowel syndrome (IBS, or spastic colon) is a symptom-based diagnosis characterized by chronic... more...

Aliases & Classifications for Irritable Bowel Syndrome

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Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 34MedlinePlus, 62UMLS, 27ICD9CM, 58SNOMED-CT, 35MeSH, 40NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

irritable bowel syndrome 8 43 10 34 62
inflammatory bowel diseases 62
irritable colon 8
ibd 8


External Ids:

Disease Ontology8 DOID:9778
ICD9CM27 564.1
MeSH35 D043183
NCIt40 C82343
ICD1025 K58, K58.0, K58.9

Related Diseases for Irritable Bowel Syndrome

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Irritable Bowel Syndrome:



Diseases related to irritable bowel syndrome

Symptoms for Irritable Bowel Syndrome

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Drugs & Therapeutics for Irritable Bowel Syndrome

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Genetic Tests for Irritable Bowel Syndrome

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Anatomical Context for Irritable Bowel Syndrome

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33MalaCards
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MalaCards organs/tissues related to Irritable Bowel Syndrome:

33
Colon, Testes, Kidney, Brain, Small intestine, Prostate, Pituitary, Cortex, Heart, Amygdala, Cerebellum, Liver, Breast, Bone, Prefrontal cortex

Animal Models for Irritable Bowel Syndrome or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Irritable Bowel Syndrome:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.3SLC6A4, HTR3A, CCKAR, CCK, CLCN2
2MP:00053867.4CLCN2, ADRA2A, ADRA2C, CCKAR, HTR3A, SLC6A4
3MP:00053767.3CLCN2, ADRA2A, ADRA2C, CCK, CCKAR, HTR3A
4MP:00036316.9SLC6A4, GNB3, CLCN2, ADRA2A, ADRA2C, CCK

Publications for Irritable Bowel Syndrome

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Sources:
52PubMed
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Articles related to Irritable Bowel Syndrome:

(show top 50)    (show all 757)
idTitleAuthorsYear
1
Review article: linaclotide for the management of irritable bowel syndrome with constipation. (24433216)
2014
2
Faecal microbiota composition and host-microbe cross-talk following gastroenteritis and in postinfectious irritable bowel syndrome. (24310267)
2013
3
Effect of Ramosetron on Stool Consistency in Male Patients With Irritable Bowel Syndrome With Diarrhea. (24315882)
2013
4
Diffusion tensor imaging detects microstructural reorganization in the brain associated with chronic irritable bowel syndrome. (23721972)
2013
5
Irritable bowel syndrome-type symptoms in female patients with mild systemic lupus erythematosus: frequency, related factors and quality of life. (24112121)
2013
6
Gastrointestinal permeability in patients with irritable bowel syndrome assessed using a four probe permeability solution. (23328210)
2013
7
Irritable bowel syndrome in women. (23279011)
2013
8
Linaclotide: a novel compound for the treatment of irritable bowel syndrome with constipation. (24007408)
2013
9
Metabolic and toxicological considerations for the latest drugs used to treat irritable bowel syndrome. (23330973)
2013
10
Comparison of Manning, Rome I, II, and III, and Asian diagnostic criteria: report of the Multicentric Indian Irritable Bowel Syndrome (MIIBS) study. (23999682)
2013
11
Linaclotide-a novel secretagogue in the treatment of irritable bowel syndrome with constipation and chronic idiopathic constipation. (24001336)
2013
12
Effect of transcranial magnetic stimulation on rectal sensitivity in irritable bowel syndrome: a randomised, placebo-controlled pilot study. (24119239)
2013
13
Hypnotherapy: first line treatment for children with irritable bowel syndrome? (23456974)
2013
14
It is time to plan further researches on altered nutrient-sensing in irritable bowel syndrome. (23148699)
2013
15
Update on irritable bowel syndrome program of research. (24351989)
2013
16
Polymorphisms: Genetic variations associated with irritable bowel syndrome. (24206546)
2013
17
How patients with long-term experience of living with irritable bowel syndrome manage illness in daily life: a qualitative study. (24047860)
2013
18
Rifaximin in the treatment of irritable bowel syndrome: is there a high risk for development of antimicrobial resistance? (23340064)
2013
19
Linaclotide, novel therapy for the treatment of chronic idiopathic constipation and constipation-predominant irritable bowel syndrome. (23436110)
2013
20
Cognitive-behavioral therapy for the management of irritable bowel syndrome. (24379577)
2013
21
Mental, physical, dietary, and nutritional effects on irritable bowel syndrome in young Japanese women. (23774537)
2013
22
Association between irritable bowel syndrome and restless legs syndrome in the general population. (22463600)
2012
23
What is irritable bowel syndrome? (23152730)
2012
24
Is There Enough Evidence for the Association of GNI^3 C825T Polymorphism With Functional Dyspepsia and Irritable Bowel Syndrome? (22837889)
2012
25
The global perspective on irritable bowel syndrome: a Rome Foundation-World Gastroenterology Organisation symposium. (23160283)
2012
26
An Update on Post-infectious Irritable Bowel Syndrome: Role of Genetics, Immune Activation, Serotonin and Altered Microbiome. (22837873)
2012
27
Targeted therapies for diarrhea-predominant irritable bowel syndrome. (22754282)
2012
28
Lactase persistence/non-persistence genetic variants in irritable bowel syndrome in an endemic area for lactose malabsorption. (22989008)
2012
29
Is There Enough Evidence for the Association of GNI^3 C825T Polymorphism With Functional Dyspepsia and Irritable Bowel Syndrome?: Author's Reply. (22837890)
2012
30
Functional dyspepsia: subtypes, risk factors, and overlap with irritable bowel syndrome in a population of african patients. (23213327)
2012
31
New paradigm for studying genetic contributions to irritable bowel syndrome. (22926498)
2012
32
Irritable bowel syndrome: physicians' awareness and patients' experience. (22851864)
2012
33
Fermentable carbohydrate restriction reduces luminal bifidobacteria and gastrointestinal symptoms in patients with irritable bowel syndrome. (22739368)
2012
34
Colonic expression of Runx3 protein and TGF-I^(1) and their correlation in patients with irritable bowel syndrome. (21803306)
2011
35
Pro-inflammatory chemokine C-C motif ligand 16 (CCL-16) dysregulation in irritable bowel syndrome (IBS): a pilot study. (21951809)
2011
36
Serum correlates of the placebo effect in irritable bowel syndrome. (20028464)
2010
37
Increased proteasome-mediated degradation of occludin in irritable bowel syndrome. (19997094)
2010
38
Chenodeoxycholate in females with irritable bowel syndrome-constipation: a pharmacodynamic and pharmacogenetic analysis. (20691689)
2010
39
Genetic determination of irritable bowel syndrome. (19034965)
2008
40
Development of functional diarrhea, constipation, irritable bowel syndrome, and dyspepsia during and after traveling outside the USA. (17549631)
2008
41
Characterization of autonomic dysfunction in patients with irritable bowel syndrome using fingertip blood flow. (18248583)
2008
42
Serotonin transporter gene polymorphism and irritable bowel syndrome. (17040410)
2006
43
CRF1 receptor signaling pathways are involved in stress-related alterations of colonic function and viscerosensitivity: implications for irritable bowel syndrome. (15100165)
2004
44
Altered visceral perceptual and neuroendocrine response in patients with irritable bowel syndrome during mental stress. (15247175)
2004
45
Interleukin 10 genotypes in irritable bowel syndrome: evidence for an inflammatory component? (12477767)
2003
46
Irritable bowel syndrome. Survey of definitions, differential diagnosis and pathogenesis]. (11475255)
2001
47
Irritable bowel syndrome: new agents targeting serotonin receptor subtypes. (11293643)
2001
48
Inhibition of gastric secretion relieves diarrhea and postprandial urgency associated with irritable bowel syndrome or functional diarrhea. (10505731)
1999
49
Role of irritable bowel syndrome in subjective lactose intolerance. (9537618)
1998
50
Cholecystokinin's role in regulation of colonic motility in health and in irritable bowel syndrome. (1587408)
1992

Variations for Irritable Bowel Syndrome

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Expression for genes affiliated with Irritable Bowel Syndrome

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Irritable Bowel Syndrome

Search GEO for disease gene expression data for Irritable Bowel Syndrome.

Pathways for genes affiliated with Irritable Bowel Syndrome

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Sources:
50PathCards, 55Reactome, 38NCBI BioSystems Database, 51PharmGKB, 53QIAGEN, 60Thomson Reuters, 30KEGG
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Pathways related to Irritable Bowel Syndrome according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6HTR3E, HTR3A
2
Show member pathways
9.5ADRA2C, ADRA2A
3
Show member pathways
9.5ADRA2A, ADRA2C
49.5ADRA2A, ADRA2C
59.4SLC6A4, HTR3A
6
Show member pathways
9.2CCKAR, CCK, GNB3
7
Show member pathways
9.2CLCN2, HTR3A, HTR3E
8
Show member pathways
9.0ADRA2C, ADRA2A, GNB3
9
Show member pathways
9.0GNB3, ADRA2A, ADRA2C
10
Show member pathways
9.0GNB3, ADRA2A, ADRA2C
11
Show member pathways
Apoptosis and survival BAD phosphorylation60
Development Alpha 2 adrenergic receptor activation of ERK60
Chemotaxis CXCR4 signaling pathway60
9.0GNB3, ADRA2A, ADRA2C
128.8SLC6A4, HTR3A, GNB3
13
Show member pathways
8.7HTR3E, HTR3A, CLCN2, GNB3
14
Show member pathways
8.7ADRA2C, ADRA2A, CLCN2, GNB3
15
Show member pathways
8.3CCKAR, CCK, ADRA2C, ADRA2A, GNB3
16
Show member pathways
8.3CCKAR, CCK, ADRA2C, ADRA2A, GNB3
17
Show member pathways
8.2GNB3, HTR3A, HTR3E, SLC6A4

Compounds for genes affiliated with Irritable Bowel Syndrome

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Sources:
45Novoseek, 29IUPHAR, 61Tocris Bioscience, 51PharmGKB, 24HMDB, 11DrugBank, 3BitterDB
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Compounds related to Irritable Bowel Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 122)
idCompoundScoreTop Affiliating Genes
11,4-benzodiazepine4510.1CCK, CCKAR
2asperlicin4510.1CCKAR, CCK
3l3652604510.0CCK, CCKAR
4ym0224510.0CCK, CCKAR
5lorglumide45 2910.9CCKAR, CCK
6atipamezole hydrochloride619.9ADRA2C, ADRA2A
7dexmedetomidine hydrochloride619.9ADRA2A, ADRA2C
8dexloxiglumide45 2910.9HTR3A, CCK, CCKAR
9jp 1302 dihydrochloride619.9ADRA2C, ADRA2A
10benzodiazepines459.9CCKAR, HTR3A, CCK
11brl 44408299.9ADRA2C, ADRA2A
12arc-239299.9ADRA2A, ADRA2C
13rx821002299.9ADRA2A, ADRA2C
14benzodiazepine459.9CCK, HTR3A, CCKAR
15[3h]rx821002299.9ADRA2A, ADRA2C
16[3h]mk-912299.8ADRA2A, ADRA2C
17brl 44408 maleate619.8ADRA2A, ADRA2C
18medetomidine hydrochloride619.8ADRA2A, ADRA2C
19devazepide45 61 2911.8CCKAR, CCK
20omeprazole45 51 29 24 1113.8CCKAR, CCK, CLCN2
21[3h]rauwolscine299.7ADRA2C, ADRA2A
22xylazine45 2910.7ADRA2A, ADRA2C
23aripiprazole29 45 51 24 1113.6ADRA2A, ADRA2C, HTR3A
24ziprasidone29 51 45 1112.6ADRA2C, ADRA2A, HTR3A
25yohimbine45 3 29 1112.6HTR3A, ADRA2A, ADRA2C
26chlorpromazine29 45 51 1112.6ADRA2A, ADRA2C, HTR3A
27tetrodotoxin45 61 2911.6HTR3A, CCKAR, CCK
28ondansetron hydrochloride619.6HTR3A, HTR3E
29sr 57227 hydrochloride619.6HTR3A, HTR3E
30granisetron hydrochloride619.5HTR3E, HTR3A
31alosetron45 1110.4SLC6A4, HTR3A, CCK
32tegaserod45 29 1111.4CCK, SLC6A4, HTR3A
33fenfluramine45 29 1111.4HTR3A, CCK, SLC6A4
34tropisetron hydrochloride619.3HTR3A, HTR3E
35nefazodone45 51 1111.3ADRA2A, HTR3A, SLC6A4
36mianserin45 29 1111.2SLC6A4, ADRA2A, HTR3A
37mirtazapine45 51 1111.2ADRA2A, SLC6A4, HTR3A
38amitriptyline45 29 51 1112.2HTR3A, ADRA2A, SLC6A4
39doxepin45 29 51 1112.1ADRA2C, ADRA2A, SLC6A4
40fluoxetine45 51 29 1112.1GNB3, HTR3A, SLC6A4
41ondansetron51 45 24 1112.1CCK, HTR3A, CCKAR, SLC6A4
42gaba459.0HTR3A, CCK, CCKAR, SLC6A4
43methamphetamine45 51 1111.0SLC6A4, ADRA2A, ADRA2C
44quetiapine45 51 29 24 1112.9HTR3A, ADRA2A, ADRA2C, SLC6A4
45risperidone45 51 29 61 24 1113.9HTR3A, ADRA2A, ADRA2C, SLC6A4
46clonidine45 51 29 1111.6ADRA2A, ADRA2C, GNB3, SLC6A4
47olanzapine45 51 29 24 1112.3SLC6A4, ADRA2A, ADRA2C, HTR3A, GNB3
48clozapine45 29 51 1111.3ADRA2C, GNB3, HTR3A, SLC6A4, ADRA2A
49norepinephrine45 24 1110.0ADRA2C, HTR3A, ADRA2A, GNB3, SLC6A4, CCK
50dopamine45 29 24 1110.6SLC6A4, GNB3, ADRA2A, ADRA2C, CCK, CCKAR

GO Terms for genes affiliated with Irritable Bowel Syndrome

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16Gene Ontology
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Cellular components related to Irritable Bowel Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058877.6ADRA2A, ADRA2C, CCKAR, HTR3A, SLC6A4, TNFSF15
2plasma membraneGO:0058865.8SLC6A4, GNB3, TNFSF15, CLCN2, ADRA2A, ADRA2C

Biological processes related to Irritable Bowel Syndrome according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1digestionGO:0075869.8HTR3A, CCKAR
2negative regulation of uterine smooth muscle contractionGO:0704739.8ADRA2C, ADRA2A
3activation of MAPK activity by adrenergic receptor signaling pathwayGO:0718839.8ADRA2C, ADRA2A
4epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathwayGO:0356259.7ADRA2A, ADRA2C
5negative regulation of epinephrine secretionGO:0328119.7ADRA2C, ADRA2A
6negative regulation of norepinephrine secretionGO:0107009.7ADRA2C, ADRA2A
7regulation of sensory perception of painGO:0519309.6ADRA2C, CCK
8activation of protein kinase B activityGO:0321489.6ADRA2C, ADRA2A
9ion transmembrane transportGO:0342209.2HTR3E, HTR3A, CLCN2
10energy reserve metabolic processGO:0061129.1GNB3, ADRA2A, ADRA2C
11G-protein coupled receptor signaling pathwayGO:0071868.7ADRA2C, ADRA2A, GNB3

Molecular functions related to Irritable Bowel Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1epinephrine bindingGO:0513799.5ADRA2C, ADRA2A
2alpha2-adrenergic receptor activityGO:0049389.2ADRA2C, ADRA2A

Products for genes affiliated with Irritable Bowel Syndrome

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  • Antibodies
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Sources for Irritable Bowel Syndrome

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet