MCID: IRR002
MIFTS: 56

Irritable Bowel Syndrome malady

Rare diseases, Gastrointestinal diseases, Blood diseases categories

Summaries for Irritable Bowel Syndrome

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MedlinePlus:32 Irritable bowel syndrome (ibs) is a problem that affects the large intestine. it can cause abdominal cramping, bloating, and a change in bowel habits. some people with the disorder have constipation. some have diarrhea. others go back and forth between the two. although ibs can cause a great deal of discomfort, it does not harm the intestines. ibs is common. it affects about twice as many women as men and is most often found in people younger than 45 years. no one knows the exact cause of ibs. there is no specific test for it. your doctor may run tests to be sure you don't have other diseases. these tests may include stool sampling tests, blood tests, and x-rays. your doctor may also do a test called a sigmoidoscopy or colonoscopy. most people diagnosed with ibs can control their symptoms with diet, stress management, probiotics, and medicine. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary: Irritable Bowel Syndrome, also known as ibd, is related to dyspepsia and constipation. An important gene associated with Irritable Bowel Syndrome is MIR510 (microRNA 510), and among its related pathways are Ligand-gated ion channel transport and Integrin alphaIIb beta3 signaling. The drugs hyoscyamine sulfate and propantheline and the compounds 1,4-benzodiazepine and asperlicin have been mentioned in the context of this disorder. Affiliated tissues include colon, testes and kidney, and related mouse phenotypes are endocrine/exocrine gland and behavior/neurological.

Disease Ontology:9 A syndrome that is a functional bowel disorder characterized by chronic abdominal pain, discomfort, bloating, and alteration of bowel habits in the absence of any detectable organic cause.

Wikipedia:63 Irritable bowel syndrome (IBS) or spastic colon is a symptom-based diagnosis. It is characterized by... more...

Aliases & Classifications for Irritable Bowel Syndrome

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Irritable Bowel Syndrome, Aliases & Descriptions:

Name: Irritable Bowel Syndrome 9 41 11 32 60
Ibd 9 3
 
Irritable Colon 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Gastrointestinal diseases, Blood diseases


External Ids:

Disease Ontology9 DOID:9778
ICD9CM27 564.1
NCIt38 C82343
MeSH33 D043183
ICD1025 K58, K58.0, K58.9

Related Diseases for Irritable Bowel Syndrome

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Diseases related to Irritable Bowel Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 155)
idRelated DiseaseScoreTop Affiliating Genes
1dyspepsia31.9CCK, HTR3A
2constipation31.5CCK, HTR3A, SLC6A4
3gastroesophageal reflux31.3CCK, CCKAR
4fibromyalgia31.0SLC6A4, HTR3A
5anxiety disorder30.8HTR3A, SLC6A4
6generalized anxiety disorder30.7HTR3A, SLC6A4
7premature ejaculation30.6SLC6A4
8gallbladder disease30.5CCK, CCKAR
9panic disorder30.4CCK, CCKAR, HTR3A, SLC6A4
10bulimia nervosa30.4CCK, SLC6A4
11obesity30.0GNB3, ADRA2A, CCK, CCKAR
12diarrhea11.0
13inflammatory bowel disease10.8
14colitis10.8
15lactose intolerance10.7
16blindness10.7
17ulcerative colitis10.6
18celiac disease10.6
19gastroenteritis10.6
20microscopic colitis10.6
21motion sickness10.5HTR3A
22serotonin syndrome10.5HTR3A
23functional diarrhea10.4
24restless legs syndrome10.4
25migraine10.4
26chronic fatigue syndrome10.4
27infertility10.4
28duodenitis10.4
29diverticulitis10.4
30dysentery10.4
31endometriosis10.4
32esophagitis10.4
33pelvic inflammatory disease10.4
34prostatitis10.4
35gastroparesis10.3CCK, HTR3A
36isobutyryl-coa dehydrogenase deficiency10.3
37osteoporosis10.3
38crohn's disease10.3
39fecal incontinence10.3
40giardiasis10.3
41neuronitis10.3
42agoraphobia10.3
43somatization disorder10.3
44pancreas disease10.3CCKAR, CCK
45gastrointestinal system disease10.3CCK, CCKAR
46major depressive disorder and accelerated response to antidepressant drug treatment10.2SLC6A4
47eating disorder10.2SLC6A4
48sclerosing cholangitis10.2
49cholangitis10.2
50pain agnosia10.2HTR3A, CCKAR, CCK

Graphical network of the top 20 diseases related to Irritable Bowel Syndrome:



Diseases related to irritable bowel syndrome

Symptoms for Irritable Bowel Syndrome

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Drugs & Therapeutics for Irritable Bowel Syndrome

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Genetic Tests for Irritable Bowel Syndrome

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Anatomical Context for Irritable Bowel Syndrome

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MalaCards organs/tissues related to Irritable Bowel Syndrome:

31
Colon, Testes, Kidney, Brain, Small intestine, Prostate, Cortex, Pituitary, Bone, Cerebellum, Heart, Liver, Breast, Prefrontal cortex, Amygdala, Neutrophil

Animal Models for Irritable Bowel Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Irritable Bowel Syndrome:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.3SLC6A4, HTR3A, CCKAR, CCK, CLCN2
2MP:00053867.4CLCN2, ADRA2A, ADRA2C, CCKAR, HTR3A, SLC6A4
3MP:00053767.3CLCN2, ADRA2A, ADRA2C, CCK, CCKAR, HTR3A
4MP:00036316.9SLC6A4, GNB3, CLCN2, ADRA2A, ADRA2C, CCK

Publications for Irritable Bowel Syndrome

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Articles related to Irritable Bowel Syndrome:

(show top 50)    (show all 812)
idTitleAuthorsYear
1
Presence of tissue transglutaminase IgA antibody as a celiac disease marker in a sample of patients with irritable bowel syndrome. (25856876)
2015
2
Clinical pilot study: efficacy of triple antibiotic therapy in Blastocystis positive irritable bowel syndrome patients. (25349629)
2014
3
Incidence and predictive factors of irritable bowel syndrome after acute diverticulitis in Korea. (25255851)
2014
4
Review article: linaclotide for the management of irritable bowel syndrome with constipation. (24433216)
2014
5
Faecal microbiota composition and host-microbe cross-talk following gastroenteritis and in postinfectious irritable bowel syndrome. (24310267)
2013
6
Effect of Ramosetron on Stool Consistency in Male Patients With Irritable Bowel Syndrome With Diarrhea. (24315882)
2013
7
Diffusion tensor imaging detects microstructural reorganization in the brain associated with chronic irritable bowel syndrome. (23721972)
2013
8
Irritable bowel syndrome-type symptoms in female patients with mild systemic lupus erythematosus: frequency, related factors and quality of life. (24112121)
2013
9
Gastrointestinal permeability in patients with irritable bowel syndrome assessed using a four probe permeability solution. (23328210)
2013
10
Irritable bowel syndrome in women. (23279011)
2013
11
Linaclotide: a novel compound for the treatment of irritable bowel syndrome with constipation. (24007408)
2013
12
Metabolic and toxicological considerations for the latest drugs used to treat irritable bowel syndrome. (23330973)
2013
13
Comparison of Manning, Rome I, II, and III, and Asian diagnostic criteria: report of the Multicentric Indian Irritable Bowel Syndrome (MIIBS) study. (23999682)
2013
14
Linaclotide-a novel secretagogue in the treatment of irritable bowel syndrome with constipation and chronic idiopathic constipation. (24001336)
2013
15
Effect of transcranial magnetic stimulation on rectal sensitivity in irritable bowel syndrome: a randomised, placebo-controlled pilot study. (24119239)
2013
16
Hypnotherapy: first line treatment for children with irritable bowel syndrome? (23456974)
2013
17
It is time to plan further researches on altered nutrient-sensing in irritable bowel syndrome. (23148699)
2013
18
Update on irritable bowel syndrome program of research. (24351989)
2013
19
Polymorphisms: Genetic variations associated with irritable bowel syndrome. (24206546)
2013
20
Association between irritable bowel syndrome and colorectal cancer: A nationwide population-based study. (24268837)
2013
21
How patients with long-term experience of living with irritable bowel syndrome manage illness in daily life: a qualitative study. (24047860)
2013
22
Rifaximin in the treatment of irritable bowel syndrome: is there a high risk for development of antimicrobial resistance? (23340064)
2013
23
Linaclotide, novel therapy for the treatment of chronic idiopathic constipation and constipation-predominant irritable bowel syndrome. (23436110)
2013
24
Cognitive-behavioral therapy for the management of irritable bowel syndrome. (24379577)
2013
25
Association between irritable bowel syndrome and restless legs syndrome in the general population. (22463600)
2012
26
What is irritable bowel syndrome? (23152730)
2012
27
Is There Enough Evidence for the Association of GNI^3 C825T Polymorphism With Functional Dyspepsia and Irritable Bowel Syndrome? (22837889)
2012
28
The global perspective on irritable bowel syndrome: a Rome Foundation-World Gastroenterology Organisation symposium. (23160283)
2012
29
An Update on Post-infectious Irritable Bowel Syndrome: Role of Genetics, Immune Activation, Serotonin and Altered Microbiome. (22837873)
2012
30
Targeted therapies for diarrhea-predominant irritable bowel syndrome. (22754282)
2012
31
Lactase persistence/non-persistence genetic variants in irritable bowel syndrome in an endemic area for lactose malabsorption. (22989008)
2012
32
Is There Enough Evidence for the Association of GNI^3 C825T Polymorphism With Functional Dyspepsia and Irritable Bowel Syndrome?: Author's Reply. (22837890)
2012
33
Functional dyspepsia: subtypes, risk factors, and overlap with irritable bowel syndrome in a population of african patients. (23213327)
2012
34
Irritable bowel syndrome and the elusive mast cells. (22552242)
2012
35
New paradigm for studying genetic contributions to irritable bowel syndrome. (22926498)
2012
36
Irritable bowel syndrome: physicians' awareness and patients' experience. (22851864)
2012
37
Colonic expression of Runx3 protein and TGF-I^(1) and their correlation in patients with irritable bowel syndrome. (21803306)
2011
38
Serum correlates of the placebo effect in irritable bowel syndrome. (20028464)
2010
39
Increased proteasome-mediated degradation of occludin in irritable bowel syndrome. (19997094)
2010
40
Chenodeoxycholate in females with irritable bowel syndrome-constipation: a pharmacodynamic and pharmacogenetic analysis. (20691689)
2010
41
Genetic determination of irritable bowel syndrome. (19034965)
2008
42
Development of functional diarrhea, constipation, irritable bowel syndrome, and dyspepsia during and after traveling outside the USA. (17549631)
2008
43
Characterization of autonomic dysfunction in patients with irritable bowel syndrome using fingertip blood flow. (18248583)
2008
44
Serotonin transporter gene polymorphism and irritable bowel syndrome. (17040410)
2006
45
CRF1 receptor signaling pathways are involved in stress-related alterations of colonic function and viscerosensitivity: implications for irritable bowel syndrome. (15100165)
2004
46
Altered visceral perceptual and neuroendocrine response in patients with irritable bowel syndrome during mental stress. (15247175)
2004
47
Interleukin 10 genotypes in irritable bowel syndrome: evidence for an inflammatory component? (12477767)
2003
48
Irritable bowel syndrome. Survey of definitions, differential diagnosis and pathogenesis]. (11475255)
2001
49
Inhibition of gastric secretion relieves diarrhea and postprandial urgency associated with irritable bowel syndrome or functional diarrhea. (10505731)
1999
50
Cholecystokinin's role in regulation of colonic motility in health and in irritable bowel syndrome. (1587408)
1992

Variations for Irritable Bowel Syndrome

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Expression for genes affiliated with Irritable Bowel Syndrome

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Search GEO for disease gene expression data for Irritable Bowel Syndrome.

Pathways for genes affiliated with Irritable Bowel Syndrome

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Pathways related to Irritable Bowel Syndrome according to GeneCards Suite gene sharing:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6HTR3E, HTR3A
2
Show member pathways
9.5ADRA2C, ADRA2A
3
Show member pathways
9.5ADRA2A, ADRA2C
49.5ADRA2A, ADRA2C
59.4SLC6A4, HTR3A
6
Show member pathways
9.2CCKAR, CCK, GNB3
7
Show member pathways
9.2CLCN2, HTR3A, HTR3E
8
Show member pathways
9.0ADRA2C, ADRA2A, GNB3
9
Show member pathways
9.0GNB3, ADRA2A, ADRA2C
10
Show member pathways
9.0GNB3, ADRA2A, ADRA2C
11
Show member pathways
Apoptosis and survival BAD phosphorylation58
Development Alpha 2 adrenergic receptor activation of ERK58
Chemotaxis CXCR4 signaling pathway58
9.0GNB3, ADRA2A, ADRA2C
128.8SLC6A4, HTR3A, GNB3
13
Show member pathways
8.7HTR3E, HTR3A, CLCN2, GNB3
14
Show member pathways
8.7ADRA2C, ADRA2A, CLCN2, GNB3
15
Show member pathways
8.3CCKAR, CCK, ADRA2C, ADRA2A, GNB3
16
Show member pathways
8.3CCKAR, CCK, ADRA2C, ADRA2A, GNB3
17
Show member pathways
8.2GNB3, HTR3A, HTR3E, SLC6A4

Compounds for genes affiliated with Irritable Bowel Syndrome

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Compounds related to Irritable Bowel Syndrome according to GeneCards Suite gene sharing:

(show top 50)    (show all 122)
idCompoundScoreTop Affiliating Genes
11,4-benzodiazepine4310.1CCK, CCKAR
2asperlicin4310.1CCKAR, CCK
3l3652604310.0CCK, CCKAR
4ym0224310.0CCK, CCKAR
5lorglumide43 2810.9CCKAR, CCK
6atipamezole hydrochloride599.9ADRA2C, ADRA2A
7dexmedetomidine hydrochloride599.9ADRA2A, ADRA2C
8dexloxiglumide43 2810.9HTR3A, CCK, CCKAR
9jp 1302 dihydrochloride599.9ADRA2C, ADRA2A
10benzodiazepines439.9CCKAR, HTR3A, CCK
11brl 44408289.9ADRA2C, ADRA2A
12arc-239289.9ADRA2A, ADRA2C
13rx821002289.9ADRA2A, ADRA2C
14benzodiazepine439.9CCK, HTR3A, CCKAR
15[3h]rx821002289.9ADRA2A, ADRA2C
16[3h]mk-912289.8ADRA2A, ADRA2C
17brl 44408 maleate599.8ADRA2A, ADRA2C
18medetomidine hydrochloride599.8ADRA2A, ADRA2C
19devazepide43 59 2811.8CCKAR, CCK
20omeprazole43 49 28 24 1213.8CCKAR, CCK, CLCN2
21[3h]rauwolscine289.7ADRA2C, ADRA2A
22xylazine43 2810.7ADRA2A, ADRA2C
23aripiprazole28 43 49 24 1213.6ADRA2A, ADRA2C, HTR3A
24ziprasidone28 49 43 1212.6ADRA2C, ADRA2A, HTR3A
25yohimbine43 2 28 1212.6HTR3A, ADRA2A, ADRA2C
26chlorpromazine28 43 49 1212.6ADRA2A, ADRA2C, HTR3A
27tetrodotoxin43 59 2811.6HTR3A, CCKAR, CCK
28ondansetron hydrochloride599.6HTR3A, HTR3E
29sr 57227 hydrochloride599.6HTR3A, HTR3E
30granisetron hydrochloride599.5HTR3E, HTR3A
31alosetron43 1210.4SLC6A4, HTR3A, CCK
32tegaserod43 28 1211.4CCK, SLC6A4, HTR3A
33fenfluramine43 28 1211.4HTR3A, CCK, SLC6A4
34tropisetron hydrochloride599.3HTR3A, HTR3E
35nefazodone43 49 1211.3ADRA2A, HTR3A, SLC6A4
36mianserin43 28 1211.2SLC6A4, ADRA2A, HTR3A
37mirtazapine43 49 1211.2ADRA2A, SLC6A4, HTR3A
38amitriptyline43 28 49 1212.2HTR3A, ADRA2A, SLC6A4
39doxepin43 28 49 1212.1ADRA2C, ADRA2A, SLC6A4
40fluoxetine43 49 28 1212.1GNB3, HTR3A, SLC6A4
41ondansetron49 43 24 1212.1CCK, HTR3A, CCKAR, SLC6A4
42gaba439.0HTR3A, CCK, CCKAR, SLC6A4
43methamphetamine43 49 1211.0SLC6A4, ADRA2A, ADRA2C
44quetiapine43 49 28 24 1212.9HTR3A, ADRA2A, ADRA2C, SLC6A4
45risperidone43 49 28 59 24 1213.9HTR3A, ADRA2A, ADRA2C, SLC6A4
46clonidine43 49 28 1211.6ADRA2A, ADRA2C, GNB3, SLC6A4
47olanzapine43 49 28 24 1212.3SLC6A4, ADRA2A, ADRA2C, HTR3A, GNB3
48clozapine43 28 49 1211.3ADRA2C, GNB3, HTR3A, SLC6A4, ADRA2A
49norepinephrine43 24 1210.0ADRA2C, HTR3A, ADRA2A, GNB3, SLC6A4, CCK
50dopamine43 28 24 1210.6SLC6A4, GNB3, ADRA2A, ADRA2C, CCK, CCKAR

GO Terms for genes affiliated with Irritable Bowel Syndrome

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Cellular components related to Irritable Bowel Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:00058877.6ADRA2A, ADRA2C, CCKAR, HTR3A, SLC6A4, TNFSF15
2plasma membraneGO:00058865.8SLC6A4, GNB3, TNFSF15, CLCN2, ADRA2A, ADRA2C

Biological processes related to Irritable Bowel Syndrome according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1digestionGO:00075869.8HTR3A, CCKAR
2negative regulation of uterine smooth muscle contractionGO:00704739.8ADRA2C, ADRA2A
3activation of MAPK activity by adrenergic receptor signaling pathwayGO:00718839.8ADRA2C, ADRA2A
4epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathwayGO:00356259.7ADRA2A, ADRA2C
5negative regulation of epinephrine secretionGO:00328119.7ADRA2C, ADRA2A
6negative regulation of norepinephrine secretionGO:00107009.7ADRA2C, ADRA2A
7regulation of sensory perception of painGO:00519309.6ADRA2C, CCK
8activation of protein kinase B activityGO:00321489.6ADRA2C, ADRA2A
9ion transmembrane transportGO:00342209.2HTR3E, HTR3A, CLCN2
10energy reserve metabolic processGO:00061129.1GNB3, ADRA2A, ADRA2C
11G-protein coupled receptor signaling pathwayGO:00071868.7ADRA2C, ADRA2A, GNB3

Molecular functions related to Irritable Bowel Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1epinephrine bindingGO:00513799.5ADRA2C, ADRA2A
2alpha2-adrenergic receptor activityGO:00049389.2ADRA2C, ADRA2A

Products for genes affiliated with Irritable Bowel Syndrome

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Sources for Irritable Bowel Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet