IBD
MCID: IRR002
MIFTS: 68

Irritable Bowel Syndrome (IBD) malady

Gastrointestinal diseases category

Summaries for Irritable Bowel Syndrome

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8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Irritable bowel syndrome (ibs) is a problem that affects the large intestine. it can cause abdominal cramping, bloating, and a change in bowel habits. some people with the disorder have constipation. some have diarrhea. others go back and forth between the two. although ibs can cause a great deal of discomfort, it does not harm the intestines. ibs is common. it affects about twice as many women as men and is most often found in people younger than 45 years. no one knows the exact cause of ibs. there is no specific test for it. your doctor may run tests to be sure you don't have other diseases. these tests may include stool sampling tests, blood tests, and x-rays. your doctor may also do a test called a sigmoidoscopy or colonoscopy. most people diagnosed with ibs can control their symptoms with diet, stress management, probiotics, and medicine. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Irritable Bowel Syndrome, also known as inflammatory bowel diseases, is related to constipation and diarrhea. An important gene associated with Irritable Bowel Syndrome is MIR510 (microRNA 510), and among its related pathways are SLC-mediated transmembrane transport and Circadian entrainment. The drugs cromolyn sodium and clidinium and the compounds dopamine and norepinephrine have been mentioned in the context of this disorder. Affiliated tissues include colon, testes and kidney, and related mouse phenotypes are behavior/neurological and endocrine/exocrine gland.

Disease Ontology:8 A syndrome that is a functional bowel disorder characterized by chronic abdominal pain, discomfort, bloating, and alteration of bowel habits in the absence of any detectable organic cause.

Wikipedia:63 Irritable bowel syndrome (IBS, or spastic colon) is a symptom-based diagnosis characterized by chronic... more...

Aliases & Classifications for Irritable Bowel Syndrome

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 39NCIt, 27ICD9CM, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

irritable bowel syndrome 8 42 10 33 60
inflammatory bowel diseases 60
irritable colon 8
ibd 8


External Ids:

Disease Ontology8 DOID:9778
NCIt39 C82343
ICD9CM27 564.1
MeSH34 D043183
ICD1025 K58, K58.0, K58.9

Related Diseases for Irritable Bowel Syndrome

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Irritable Bowel Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 356)
idRelated DiseaseScoreTop Affiliating Genes
1constipation31.4CCK, HTR3A, HTR4, MLN, SLC6A4
2diarrhea31.4HTR3A, MLN
3dyspepsia31.2HTR3A, CCK, MLNR, MLN
4inflammatory bowel disease31.1S100A12
5ulcerative colitis30.8MLN, DEFB4A, F2RL1, AQP8
6gastroesophageal reflux disease30.7MLN, CCK, CCKAR
7panic disorder30.6CCKAR, CCK, HTR3A, SLC6A4
8chronic fatigue syndrome30.6SLC6A4
9anxiety disorder30.6SLC6A4, HTR3A
10migraine30.5SLC6A4, HTR3A
11generalized anxiety disorder30.5SLC6A4, HTR3A
12diabetes mellitus30.3CCKAR, CCK, GNB3, MLN
13gastrointestinal system disease30.3CCKAR, CCK, HTR4, MLN
14mood disorder30.1ADRA2A, SLC6A4, HTR3A, GNB3
15bulimia nervosa30.1CCK, SLC6A4
16duodenogastric reflux30.1MLN, CCK
17premature ejaculation30.1SLC6A4
18alzheimer's disease30.1CCK, S100A12, SLC6A4
19gastritis30.0CCK, MLN, DEFB4A
20obesity30.0CCKAR, CCK, GNB3, MLN, ADRA2A
21duodenal ulcer30.0DEFB4A, CCK
22functional colonic disease30.0HTR4, MLNR
23cystic fibrosis30.0DEFB4A, CLCN2, F2RL1
24bipolar disorder30.0HTR3A, SLC6A4
25acute pancreatitis30.0CCKAR, CCK, F2RL1
26peptic ulcer30.0CCK
27gallbladder disease30.0CCKAR, CCK, MLNR, MLN
28syndromic diarrhea10.9
29chromosomal disease10.7
30lactose intolerance10.6
31hepatitis10.6
32vascular disease10.6
33skin disease10.6
34functional diarrhea10.6
35colon cancer10.6
36gastroenteritis10.5
37collagen disease10.5
38rectal disease10.5
39tuberculosis10.5
40celiac disease10.5
41adult syndrome10.5
42ankylosing spondylitis10.5
43hepatitis a10.5
44arthritis10.5
45spondylitis10.5
46spondyloarthropathy10.5
47hepatitis b10.4
48multiple sclerosis10.4
49restless legs syndrome10.4
50hyperhomocysteinemia10.4

Graphical network of the top 20 diseases related to Irritable Bowel Syndrome:



Diseases related to irritable bowel syndrome

Clinical Features for Irritable Bowel Syndrome

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Drugs & Therapeutics for Irritable Bowel Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Irritable Bowel Syndrome

Drug clinical trials:

Search ClinicalTrials for Irritable Bowel Syndrome

Search NIH Clinical Center for Irritable Bowel Syndrome

Highlights from CenterWatch's Drugs in Clinical Trials Database for Irritable Bowel Syndrome:

idCompanyCompoundMechanismPhase
1Lexicon PharmaceuticalsLX1033An orally-delivered small molecule that inhibits tryptophan hydroxylaseII
2Synergy PharmaceuticalsplecanatideA synthetic analog of uroguanylin a natriuretic hormone that regulates ion and fluid transport in the GI tract.IIb
3Furiex PharmaceuticalsMuDeltaA mu-opioid receptor agonist and delta-opioid receptor antagonistIII
4Salix PharmaceuticalsrifaximinA semisynthetic rifamycin derivative and non-systemic gastrointestinal site-specific broad spectrum antibioticIII
5Tioga PharmaceuticalsasimadolineA peripheral kappa-agonistIII

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Irritable Bowel Syndrome

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Anatomical Context for Irritable Bowel Syndrome

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32MalaCards
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MalaCards organs/tissues related to Irritable Bowel Syndrome:

32
Colon, Testes, Kidney, Brain, Small intestine, Prostate, Cortex, Heart, Pituitary, Amygdala, Breast, Cerebellum, Liver, Bone, Prefrontal cortex

Animal Models for Irritable Bowel Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Irritable Bowel Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538610.5CCKAR, HTR3A, HTR4, CLCN2, F2RL1, SLC6A4
2MP:000537910.5AQP8, KLB, CCKAR, CCK, HTR3A, CLCN2
3MP:000537610.4KLB, CCKAR, CCK, HTR3A, HTR4, CLCN2
4MP:000363110.2HTR3A, GNB3, CCK, CCKAR, HTR4, CLCN2

Publications for Irritable Bowel Syndrome

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Sources:
50PubMed
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Articles related to Irritable Bowel Syndrome:

(show top 50)    (show all 769)
idTitleAuthorsYear
1
Fasting and postprandial volumes of the undisturbed colon: normal values and changes in diarrhea-predominant irritable bowel syndrome measured using serial MRI. (24131490)
2014
2
Association Study of Serotonin Transporter SLC6A4 Gene with Chinese Han Irritable Bowel Syndrome. (24392134)
2014
3
Comparison of Manning, Rome I, II, and III, and Asian diagnostic criteria: report of the Multicentric Indian Irritable Bowel Syndrome (MIIBS) study. (23999682)
2013
4
Linaclotide-a novel secretagogue in the treatment of irritable bowel syndrome with constipation and chronic idiopathic constipation. (24001336)
2013
5
How patients with long-term experience of living with irritable bowel syndrome manage illness in daily life: a qualitative study. (24047860)
2013
6
Comment on: Rifaximin in the treatment of irritable bowel syndrome. is there a high risk for development of antimicrobial resistance? (23751850)
2013
7
Homeopathy for treatment of irritable bowel syndrome. (24222383)
2013
8
A meta-analysis of the therapeutic effects of amitriptyline for treating irritable bowel syndrome. (23411695)
2013
9
Emerging receptor target in the pharmacotherapy of irritable bowel syndrome with constipation. (23859756)
2013
10
Peripheral mechanisms in irritable bowel syndrome. (23388018)
2013
11
Irritable bowel syndrome and migraine: bystanders or partners? (23875096)
2013
12
Current and future pharmacological treatments for diarrhea-predominant irritable bowel syndrome. (23621801)
2013
13
Treatment of irritable bowel syndrome with probiotics: growing evidence. (24056591)
2013
14
Anxiety in close relationships is higher and self-esteem lower in patients with irritable bowel syndrome compared to patients with inflammatory bowel disease. (23245929)
2013
15
The Crohn's disease activity index (CDAI) is similarly elevated in patients with Crohn's disease and in patients with irritable bowel syndrome. (23432394)
2013
16
Peripheral mechanisms in irritable bowel syndrome. (23388017)
2013
17
Mental Strain and Chronic Stress among University Students with Symptoms of Irritable Bowel Syndrome. (23843782)
2013
18
Irritable bowel syndrome and organic diseases: a comparative analysis of esophageal motility. (24151359)
2013
19
Comorbidities in patients with irritable bowel syndrome with constipation or chronic idiopathic constipation: a review of the literature from the past decade. (23816770)
2013
20
Host immune response determines visceral hyperalgesia in a rat model of post-inflammatory irritable bowel syndrome. (23307099)
2013
21
A systematic review of minimal-contact psychological treatments for symptom management in irritable bowel syndrome. (23915765)
2013
22
Further validation of the visual analogue scale for irritable bowel syndrome after use in clinical practice. (23732784)
2013
23
Abnormal rectal endocrine cells in patients with irritable bowel syndrome. (24316398)
2013
24
Prevalence of irritable bowel syndrome in South America. (22902775)
2013
25
Autonomic response to a visceral stressor is dysregulated in irritable bowel syndrome and correlates with duration of disease. (23822743)
2013
26
Association between irritable bowel syndrome and restless legs syndrome in the general population. (22463600)
2012
27
Irritable bowel syndrome in children explained. (22866532)
2012
28
JCM-16021, a Chinese Herbal Formula, Attenuated Visceral Hyperalgesia in TNBS-Induced Postinflammatory Irritable Bowel Syndrome through Reducing Colonic EC Cell Hyperplasia and Serotonin Availability in Rats. (22719782)
2012
29
Effect of gender on prevalence of irritable bowel syndrome in the community: systematic review and meta-analysis. (22613905)
2012
30
Irritable bowel syndrome: diagnosis and pathogenesis. (23066308)
2012
31
Cytokine gene polymorphisms are associated with irritable bowel syndrome: a systematic review and meta-analysis. (22897390)
2012
32
Polymorphisms of the Serotonin Transporter Gene and G-Protein I^3 Subunit Gene in Korean Children with Irritable Bowel Syndrome and Functional Dyspepsia. (22570752)
2012
33
Linaclotide: evidence for its potential use in irritable bowel syndrome and chronic constipation. (22807692)
2012
34
Tianeptine vs amitriptyline for the treatment of irritable bowel syndrome with diarrhea: a multicenter, open-label, non-inferiority, randomized controlled study. (22679908)
2012
35
The impact of irritable bowel syndrome on health-related quality of life: a Singapore perspective. (22873839)
2012
36
The effect of Korean hand acupuncture on young, single Korean students with irritable bowel syndrome. (23207783)
2012
37
The effect of Lactobacillus brevis KB290 against irritable bowel syndrome: a placebo-controlled double-blind crossover trial. (22863114)
2012
38
When is irritable bowel syndrome not irritable bowel syndrome? Diagnosis and treatment of chronic functional abdominal pain. (22644880)
2012
39
Symptomatic overlap in patients with diarrhea predominant irritable bowel syndrome and microscopic colitis in a sub group of Bangladeshi population. (22545349)
2012
40
Colonic expression of Runx3 protein and TGF-I^(1) and their correlation in patients with irritable bowel syndrome. (21803306)
2011
41
Association of alpha 2A adrenergic receptor gene (ADRAlpha2A) polymorphism with irritable bowel syndrome, microscopic and ulcerative colitis. (19833115)
2010
42
Current and novel therapeutic options for irritable bowel syndrome management. (19665953)
2009
43
Genetics and irritable bowel syndrome: from genomics to intermediate phenotype and pharmacogenetics. (19655247)
2009
44
Serum leptin levels and irritable bowel syndrome: a new hypothesis. (19398923)
2009
45
Symptomatic overlap between irritable bowel syndrome and microscopic colitis. (17206699)
2007
46
Current gut-directed therapies for irritable bowel syndrome. (16836950)
2006
47
Serotonin transporter gene polymorphisms in irritable bowel syndrome and their impact on tegaserod treatment]. (17074108)
2006
48
Tegaserod: a serotonin 5-HT4 receptor agonist for treatment of constipation-predominant irritable bowel syndrome. (15645012)
2004
49
New and emerging treatments for irritable bowel syndrome and functional dyspepsia. (15989538)
2002
50
Loxiglumide, a CCK-A antagonist, in irritable bowel syndrome. A pilot multicenter clinical study. (8185213)
1994

Genetic Variations for Irritable Bowel Syndrome

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Expression for genes affiliated with Irritable Bowel Syndrome

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Irritable Bowel Syndrome

Search GEO for disease gene expression data for Irritable Bowel Syndrome.

Pathways for genes affiliated with Irritable Bowel Syndrome

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Sources:
53Reactome, 29KEGG, 37NCBI BioSystems Database, 49PharmGKB, 12EMD Millipore
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Pathways related to Irritable Bowel Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.5GNB3, HTR3A, HTR3E, CLCN2, AQP8
2
Hide members
10.5SLC6A4, HTR3E, HTR4, HTR3A, GNB3
3
Hide members
10.5KLB, CCL16, CCKAR, CCK, GNB3, HTR4
4
Hide members
10.5HTR3A, HTR4, SLC6A4, ADRA2A
5
Hide members
10.5CCKAR, CCK, GNB3, MLNR, MLN, F2RL1
6
Hide members
10.5ADRA2C, ADRA2A, GNB3
7
Hide members
10.5ADRA2A, CCL16, CCKAR, CCK, GNB3, HTR4
8
Hide members
10.5AQP8, ADRA2C, ADRA2A, GNB3
9
Hide members
10.5ADRA2A, ADRA2C

Compounds for genes affiliated with Irritable Bowel Syndrome

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB, 59Tocris Bioscience
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Compounds related to Irritable Bowel Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 123)
idCompoundScoreTop Affiliating Genes
1dopamine44 28 11 2414.0ADRA2C, CCKAR, CCK, GNB3, HTR3A, MLNR
2norepinephrine44 11 2413.0CCK, GNB3, HTR3A, F2RL1, SLC6A4, ADRA2A
3clozapine44 28 49 1114.0GNB3, HTR3A, F2RL1, SLC6A4, ADRA2A, ADRA2C
4dexloxiglumide44 2811.9MLN, HTR3A, CCK, CCKAR
5tegaserod44 28 1112.9CCK, HTR3A, HTR4, MLN, SLC6A4
6benzodiazepines4410.9CCKAR, CCK, HTR3A, F2RL1
7ondansetron44 49 11 2413.9CCKAR, CCK, HTR3A, HTR4, MLN
85-hydroxytryptamine4410.9CCK, HTR3A, HTR4, MLN, F2RL1, SLC6A4
9cisapride44 28 1112.9CCK, HTR3A, HTR4, MLNR, MLN
10mianserin28 44 1112.9ADRA2A, SLC6A4, HTR4, HTR3A
11metoclopramide44 1111.9CCK, HTR3A, HTR4, MLN
12yohimbine44 28 2 1113.9HTR3A, HTR4, ADRA2A, ADRA2C
13omeprazole44 28 49 11 2414.9CCKAR, CCK, MLN, CLCN2
14alosetron44 1111.9SLC6A4, HTR3A, CCK
15risperidone28 44 49 59 11 2415.9HTR3A, SLC6A4, ADRA2A, ADRA2C
16caerulein4410.9CCKAR, CCK, MLN
17prucalopride44 2811.9MLN, HTR4, HTR3A
18clonidine44 28 1112.9GNB3, SLC6A4, ADRA2A, ADRA2C
19olanzapine49 44 28 11 2414.9GNB3, HTR3A, ADRA2A, ADRA2C
20granisetron44 1111.9HTR4, HTR3A, CCK
21Ephedra1110.9ADRA2C, ADRA2A, SLC6A4
22tetrodotoxin44 59 2812.9CCKAR, CCK, HTR3A, MLN
23octreotide44 59 28 1113.9CCKAR, CCK, MLN, F2RL1
24gaba4410.9CCKAR, CCK, HTR3A, F2RL1, SLC6A4
25nefazodone44 49 1112.9ADRA2A, SLC6A4, HTR3A
26atropine44 28 1112.9CCKAR, CCK, HTR4, MLN
27mirtazapine49 44 1112.9HTR3A, SLC6A4, ADRA2A
28fenfluramine28 44 1112.9SLC6A4, HTR3A, CCK
29benzodiazepine4410.8HTR3A, CCK, CCKAR
30ketanserin28 4411.8HTR3A, HTR4, SLC6A4
31doxepin44 28 49 1113.8SLC6A4, ADRA2A, ADRA2C
32gr 11380844 59 2812.8HTR4, HTR3A
33mosapride44 2811.8HTR4, HTR3A
34indole4410.8HTR3A, HTR4, SLC6A4
35ranitidine44 28 11 2413.8CCK, MLN, F2RL1
36sumatriptan44 28 59 49 11 2415.8GNB3, HTR3A, MLN
37prazosin44 28 49 1113.8HTR4, ADRA2A, ADRA2C
38aripiprazole28 49 44 11 2414.8HTR3A, ADRA2A, ADRA2C
39histamine44 28 2412.7F2RL1, DEFB4A, MLN, HTR3A, CCK
40acetylcholine44 49 28 11 2414.7CCK, HTR3A, HTR4, MLN, F2RL1
41ziprasidone49 28 44 1113.7ADRA2C, ADRA2A, HTR3A
42rx8210022810.7ADRA2C, ADRA2A
43arc-2392810.7ADRA2C, ADRA2A
44brl 444082810.6ADRA2C, ADRA2A
45em 5234410.6MLN, MLNR
46brl 44408 maleate5910.6ADRA2A, ADRA2C
47medetomidine hydrochloride5910.5ADRA2A, ADRA2C
48dexmedetomidine hydrochloride5910.5ADRA2A, ADRA2C
49jp 1302 dihydrochloride5910.4ADRA2A, ADRA2C
50atipamezole hydrochloride5910.2ADRA2A, ADRA2C

GO Terms for genes affiliated with Irritable Bowel Syndrome

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Sources:
16Gene Ontology
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Cellular components related to Irritable Bowel Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:00588710.5HTR3A, HTR4, MLNR, F2RL1, SLC6A4, ADRA2A
2plasma membraneGO:00588610.2LY96, KLB, CCKAR, S100A12, GNB3, HTR3A

Biological processes related to Irritable Bowel Syndrome according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1G-protein coupled receptor signaling pathwayGO:00718610.8ADRA2C, GNB3, HTR4, MLNR, MLN, DEFB4A
2negative regulation of uterine smooth muscle contractionGO:07047310.8ADRA2C, ADRA2A
3activation of MAPK activity by adrenergic receptor signaling pathwayGO:07188310.7ADRA2A, ADRA2C
4epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathwayGO:03562510.7ADRA2C, ADRA2A
5digestionGO:00758610.7CCKAR, HTR3A, MLNR
6negative regulation of epinephrine secretionGO:03281110.7ADRA2C, ADRA2A
7negative regulation of norepinephrine secretionGO:01070010.7ADRA2C, ADRA2A
8serotonin receptor signaling pathwayGO:00721010.6HTR3A, HTR4
9inflammatory responseGO:00695410.6LY96, F2RL1, S100A12, CCL16
10energy reserve metabolic processGO:00611210.6GNB3, ADRA2A, ADRA2C
11regulation of sensory perception of painGO:05193010.5ADRA2C, CCK
12innate immune responseGO:04508710.5KLB, S100A12, DEFB4A, F2RL1, LY96
13activation of protein kinase B activityGO:03214810.4ADRA2C, ADRA2A
14ion transmembrane transportGO:03422010.2CLCN2, HTR3E, HTR3A

Molecular functions related to Irritable Bowel Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1epinephrine bindingGO:05137910.5ADRA2C, ADRA2A
2alpha2-adrenergic receptor activityGO:00493810.2ADRA2C, ADRA2A

Products for genes affiliated with Irritable Bowel Syndrome

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  • Antibodies
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  • Antibodies

Sources for Irritable Bowel Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet