IBD
MCID: IRR002
MIFTS: 68

Irritable Bowel Syndrome (IBD) malady

Gastrointestinal diseases category

Summaries for Irritable Bowel Syndrome

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8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Irritable bowel syndrome (ibs) is a problem that affects the large intestine. it can cause abdominal cramping, bloating, and a change in bowel habits. some people with the disorder have constipation. some have diarrhea. others go back and forth between the two. although ibs can cause a great deal of discomfort, it does not harm the intestines. ibs is common. it affects about twice as many women as men and is most often found in people younger than 45 years. no one knows the exact cause of ibs. there is no specific test for it. your doctor may run tests to be sure you don't have other diseases. these tests may include stool sampling tests, blood tests, and x-rays. your doctor may also do a test called a sigmoidoscopy or colonoscopy. most people diagnosed with ibs can control their symptoms with diet, stress management, probiotics, and medicine. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Irritable Bowel Syndrome, also known as inflammatory bowel diseases, is related to constipation and diarrhea. An important gene associated with Irritable Bowel Syndrome is MIR510 (microRNA 510), and among its related pathways are SLC-mediated transmembrane transport and Circadian entrainment. The drugs cromolyn sodium and clidinium and the compounds dopamine and norepinephrine have been mentioned in the context of this disorder. Affiliated tissues include colon, testes and kidney, and related mouse phenotypes are behavior/neurological and endocrine/exocrine gland.

Disease Ontology:8 A syndrome that is a functional bowel disorder characterized by chronic abdominal pain, discomfort, bloating, and alteration of bowel habits in the absence of any detectable organic cause.

Wikipedia:63 Irritable bowel syndrome (IBS, or spastic colon) is a symptom-based diagnosis characterized by chronic... more...

Aliases & Classifications for Irritable Bowel Syndrome

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 39NCIt, 27ICD9CM, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

irritable bowel syndrome 8 42 10 33 60
inflammatory bowel diseases 60
irritable colon 8
ibd 8


External Ids:

Disease Ontology8 DOID:9778
NCIt39 C82343
ICD9CM27 564.1
MeSH34 D043183
ICD1025 K58, K58.0, K58.9

Related Diseases for Irritable Bowel Syndrome

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Irritable Bowel Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 356)
idRelated DiseaseScoreTop Affiliating Genes
1constipation31.4CCK, HTR3A, HTR4, MLN, SLC6A4
2diarrhea31.4HTR3A, MLN
3dyspepsia31.2HTR3A, CCK, MLNR, MLN
4inflammatory bowel disease31.1S100A12
5ulcerative colitis30.8MLN, DEFB4A, F2RL1, AQP8
6gastroesophageal reflux disease30.7MLN, CCK, CCKAR
7panic disorder30.6CCKAR, CCK, HTR3A, SLC6A4
8chronic fatigue syndrome30.6SLC6A4
9anxiety disorder30.6SLC6A4, HTR3A
10migraine30.5SLC6A4, HTR3A
11generalized anxiety disorder30.5SLC6A4, HTR3A
12diabetes mellitus30.3CCKAR, CCK, GNB3, MLN
13gastrointestinal system disease30.3CCKAR, CCK, HTR4, MLN
14mood disorder30.1ADRA2A, SLC6A4, HTR3A, GNB3
15bulimia nervosa30.1CCK, SLC6A4
16duodenogastric reflux30.1MLN, CCK
17premature ejaculation30.1SLC6A4
18alzheimer's disease30.1CCK, S100A12, SLC6A4
19gastritis30.0CCK, MLN, DEFB4A
20obesity30.0CCKAR, CCK, GNB3, MLN, ADRA2A
21duodenal ulcer30.0DEFB4A, CCK
22functional colonic disease30.0HTR4, MLNR
23cystic fibrosis30.0DEFB4A, CLCN2, F2RL1
24bipolar disorder30.0HTR3A, SLC6A4
25acute pancreatitis30.0CCKAR, CCK, F2RL1
26peptic ulcer30.0CCK
27gallbladder disease30.0CCKAR, CCK, MLNR, MLN
28syndromic diarrhea10.9
29chromosomal disease10.7
30lactose intolerance10.6
31hepatitis10.6
32vascular disease10.6
33skin disease10.6
34functional diarrhea10.6
35colon cancer10.6
36gastroenteritis10.5
37collagen disease10.5
38rectal disease10.5
39tuberculosis10.5
40celiac disease10.5
41adult syndrome10.5
42ankylosing spondylitis10.5
43hepatitis a10.5
44arthritis10.5
45spondylitis10.5
46spondyloarthropathy10.5
47hepatitis b10.4
48multiple sclerosis10.4
49restless legs syndrome10.4
50hyperhomocysteinemia10.4

Graphical network of the top 20 diseases related to Irritable Bowel Syndrome:



Diseases related to irritable bowel syndrome

Clinical Features for Irritable Bowel Syndrome

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Drugs & Therapeutics for Irritable Bowel Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Irritable Bowel Syndrome

Drug clinical trials:

Search ClinicalTrials for Irritable Bowel Syndrome

Search NIH Clinical Center for Irritable Bowel Syndrome

Highlights from CenterWatch's Drugs in Clinical Trials Database for Irritable Bowel Syndrome:

idCompanyCompoundMechanismPhase
1Lexicon PharmaceuticalsLX1033An orally-delivered small molecule that inhibits tryptophan hydroxylaseII
2Synergy PharmaceuticalsplecanatideA synthetic analog of uroguanylin a natriuretic hormone that regulates ion and fluid transport in the GI tract.IIb
3Furiex PharmaceuticalsMuDeltaA mu-opioid receptor agonist and delta-opioid receptor antagonistIII
4Salix PharmaceuticalsrifaximinA semisynthetic rifamycin derivative and non-systemic gastrointestinal site-specific broad spectrum antibioticIII
5Tioga PharmaceuticalsasimadolineA peripheral kappa-agonistIII

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Irritable Bowel Syndrome

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Anatomical Context for Irritable Bowel Syndrome

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32MalaCards
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MalaCards organs/tissues related to Irritable Bowel Syndrome:

32
Colon, Testes, Kidney, Brain, Small intestine, Prostate, Pituitary, Heart, Cortex, Liver, Breast, Cerebellum, Prefrontal cortex, Amygdala, Bone

Animal Models for Irritable Bowel Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Irritable Bowel Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538610.5CCKAR, HTR3A, HTR4, CLCN2, F2RL1, SLC6A4
2MP:000537910.5AQP8, KLB, CCKAR, CCK, HTR3A, CLCN2
3MP:000537610.4KLB, CCKAR, CCK, HTR3A, HTR4, CLCN2
4MP:000363110.2HTR3A, GNB3, CCK, CCKAR, HTR4, CLCN2

Publications for Irritable Bowel Syndrome

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Sources:
50PubMed
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Articles related to Irritable Bowel Syndrome:

(show top 50)    (show all 769)
idTitleAuthorsYear
1
Faecal microbiota composition and host-microbe cross-talk following gastroenteritis and in postinfectious irritable bowel syndrome. (24310267)
2013
2
Relationship between overactive bladder (OAB) and irritable bowel syndrome (IBS): concurrent disorders with a common pathophysiology? (23551439)
2013
3
Moxibustion in the management of irritable bowel syndrome: systematic review and meta-analysis. (24088418)
2013
4
GP perspectives of irritable bowel syndrome--an accepted illness, but management deviates from guidelines: a qualitative study. (23805998)
2013
5
Burden of illness in irritable bowel syndrome: looking beyond the patient. (23103826)
2013
6
Symptoms of irritable bowel syndrome in patients with inflammatory bowel disease: examining the role of sub-clinical inflammation and the impact on clinical assessment of disease activity. (23668698)
2013
7
Measuring acceptance in irritable bowel syndrome: preliminary validation of an adapted scale and construct utility. (23096496)
2013
8
Common gastrointestinal symptoms: irritable bowel syndrome. (24124703)
2013
9
Atypical antipsychotics as a possible treatment option for irritable bowel syndrome. (23506326)
2013
10
Remarkable prevalence of coeliac disease in patients with irritable bowel syndrome plus fibromyalgia in comparison with those with isolated irritable bowel syndrome: a case-finding study. (24283458)
2013
11
Chronic fatigue in patients with unexplained self-reported food hypersensitivity and irritable bowel syndrome: validation of a Norwegian translation of the Fatigue Impact Scale. (23869173)
2013
12
Linaclotide in the treatment of patients with irritable bowel syndrome and constipation - analysis of an opportunity. (24090017)
2013
13
Challenges in management of irritable bowel syndrome in children. (24413506)
2013
14
Probiotics and irritable bowel syndrome. (24106397)
2013
15
Letter: serotonin transporter gene polymorphisms and the irritable bowel syndrome. (23406411)
2013
16
What does irritable bowel syndrome share with non-alcoholic fatty liver disease? (24023483)
2013
17
Serotonin transporter gene polymorphisms in Southwestern Iranian patients with irritable bowel syndrome. (23820502)
2013
18
The relationship of food intolerance and irritable bowel syndrome in adults. (23899486)
2013
19
The global perspective on irritable bowel syndrome: a Rome Foundation-World Gastroenterology Organisation symposium. (23160283)
2012
20
An Update on Post-infectious Irritable Bowel Syndrome: Role of Genetics, Immune Activation, Serotonin and Altered Microbiome. (22837873)
2012
21
Acupuncture for treatment of irritable bowel syndrome. (22592702)
2012
22
Carriage of Clostridium difficile in outpatients with irritable bowel syndrome. (22580916)
2012
23
Altered neuro-endocrine-immune pathways in the irritable bowel syndrome: the top-down and the bottom-up model. (22766747)
2012
24
Interleukin-8 and -10 gene polymorphisms in irritable bowel syndrome. (22740130)
2012
25
Key factors in developing the trinitrobenzene sulfonic acid-induced post-inflammatory irritable bowel syndrome model in rats. (22654445)
2012
26
Effect of antispasmodic agents, alone or in combination, in the treatment of Irritable Bowel Syndrome: systematic review and meta-analysis. (22672854)
2012
27
Double-blind placebo-controlled study of mesalamine in post-infective irritable bowel syndrome--a pilot study. (22783919)
2012
28
Safety and patient outcomes with lubiprostone for up to 52 weeks in patients with irritable bowel syndrome with constipation. (22251419)
2012
29
Can a mathematical model be used to estimate the contribution of acute gastroenteritis to the overall prevalence of irritable bowel syndrome? (22523720)
2012
30
Symptoms catastrophizing versus social hypervigilance in irritable bowel syndrome patients. (22967024)
2012
31
Celiac disease: Serologic prevalence in patients with irritable bowel syndrome. (23826010)
2012
32
Prevalence of gastro-esophageal reflux-type symptoms in individuals with irritable bowel syndrome in the community: a meta-analysis. (23032982)
2012
33
Diet and irritable bowel syndrome. (23256117)
2012
34
Association of TNFSF15 polymorphism with irritable bowel syndrome. (21636646)
2011
35
Elevated expression of c-fos in central nervous system correlates with visceral hypersensitivity in irritable bowel syndrome (IBS): a new target for IBS treatment. (21340718)
2011
36
Chenodeoxycholate in females with irritable bowel syndrome-constipation: a pharmacodynamic and pharmacogenetic analysis. (20691689)
2010
37
Dyspepsia and irritable bowel syndrome: mutually exclusive conditions? (20636622)
2010
38
Cytokine gene polymorphisms in irritable bowel syndrome in Indian population--a pilot case control study. (20860222)
2010
39
Duodenal mastocytosis, eosinophilia and intraepithelial lymphocytosis as possible disease markers in the irritable bowel syndrome and functional dyspepsia. (19183150)
2009
40
Evidence of an enhanced central 5HT response in irritable bowel syndrome and in the rat maternal separation model. (18194152)
2008
41
Efficacy and tolerability of alosetron for the treatment of irritable bowel syndrome in women and men: a meta-analysis of eight randomized, placebo-controlled, 12-week trials. (18555935)
2008
42
Proximal and distal gut hormone secretion in irritable bowel syndrome. (16484122)
2006
43
Association of the -1438 G/A and 102 T/C polymorphism of the 5-Ht2A receptor gene with irritable bowel syndrome 5-Ht2A gene polymorphism in irritable bowel syndrome. (15232358)
2004
44
Effect of alosetron on left colonic motility in non-constipated patients with irritable bowel syndrome and healthy volunteers. (11966509)
2002
45
H. pylori infection and visceral hypersensitivity in patients with irritable bowel syndrome. (11549828)
2001
46
Effects of probiotic administration upon the composition and enzymatic activity of human fecal microbiota in patients with irritable bowel syndrome or functional diarrhea. (11686387)
2001
47
Drug treatment options for irritable bowel syndrome: managing for success. (11302287)
2001
48
Inhibition of gastric secretion relieves diarrhea and postprandial urgency associated with irritable bowel syndrome or functional diarrhea. (10505731)
1999
49
Therapeutic approach to the patient with irritable bowel syndrome. (10588170)
1999
50
Pneumatosis cystoides intestinalis. Report of a case mimicking the irritable bowel syndrome with x-ray diagnosis and resolution. (14460896)
1962

Genetic Variations for Irritable Bowel Syndrome

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Expression for genes affiliated with Irritable Bowel Syndrome

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Irritable Bowel Syndrome

Search GEO for disease gene expression data for Irritable Bowel Syndrome.

Pathways for genes affiliated with Irritable Bowel Syndrome

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Sources:
53Reactome, 29KEGG, 37NCBI BioSystems Database, 49PharmGKB, 12EMD Millipore
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Pathways related to Irritable Bowel Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.5GNB3, HTR3A, HTR3E, CLCN2, AQP8
2
Hide members
10.5SLC6A4, HTR3E, HTR4, HTR3A, GNB3
3
Hide members
10.5KLB, CCL16, CCKAR, CCK, GNB3, HTR4
4
Hide members
10.5HTR3A, HTR4, SLC6A4, ADRA2A
5
Hide members
10.5CCKAR, CCK, GNB3, MLNR, MLN, F2RL1
6
Hide members
10.5ADRA2C, ADRA2A, GNB3
7
Hide members
10.5ADRA2A, CCL16, CCKAR, CCK, GNB3, HTR4
8
Hide members
10.5AQP8, ADRA2C, ADRA2A, GNB3
9
Hide members
10.5ADRA2A, ADRA2C

Compounds for genes affiliated with Irritable Bowel Syndrome

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB, 59Tocris Bioscience
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Compounds related to Irritable Bowel Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 123)
idCompoundScoreTop Affiliating Genes
1dopamine44 28 11 2414.0ADRA2C, CCKAR, CCK, GNB3, HTR3A, MLNR
2norepinephrine44 11 2413.0CCK, HTR3A, ADRA2A, SLC6A4, F2RL1, GNB3
3clozapine44 28 49 1114.0SLC6A4, F2RL1, HTR3A, GNB3, ADRA2C, ADRA2A
4dexloxiglumide44 2811.9CCK, HTR3A, MLN, CCKAR
5tegaserod44 28 1112.9SLC6A4, MLN, HTR4, HTR3A, CCK
6benzodiazepines4410.9CCKAR, F2RL1, HTR3A, CCK
7ondansetron44 49 11 2413.9HTR3A, HTR4, MLN, CCKAR, CCK
85-hydroxytryptamine4410.9HTR4, MLN, CCK, F2RL1, SLC6A4, HTR3A
9cisapride44 28 1112.9MLN, MLNR, HTR4, CCK, HTR3A
10mianserin28 44 1112.9HTR3A, ADRA2A, SLC6A4, HTR4
11metoclopramide44 1111.9HTR4, MLN, HTR3A, CCK
12yohimbine44 28 2 1113.9HTR3A, ADRA2A, ADRA2C, HTR4
13omeprazole44 28 49 11 2414.9CCKAR, CCK, MLN, CLCN2
14alosetron44 1111.9HTR3A, SLC6A4, CCK
15risperidone28 44 49 59 11 2415.9ADRA2A, ADRA2C, SLC6A4, HTR3A
16caerulein4410.9MLN, CCKAR, CCK
17prucalopride44 2811.9HTR4, MLN, HTR3A
18clonidine44 28 1112.9ADRA2C, ADRA2A, SLC6A4, GNB3
19olanzapine49 44 28 11 2414.9GNB3, HTR3A, ADRA2A, ADRA2C
20granisetron44 1111.9CCK, HTR3A, HTR4
21Ephedra1110.9SLC6A4, ADRA2C, ADRA2A
22tetrodotoxin44 59 2812.9CCK, MLN, HTR3A, CCKAR
23octreotide44 59 28 1113.9F2RL1, MLN, CCK, CCKAR
24gaba4410.9F2RL1, HTR3A, SLC6A4, CCKAR, CCK
25nefazodone44 49 1112.9HTR3A, ADRA2A, SLC6A4
26atropine44 28 1112.9HTR4, MLN, CCKAR, CCK
27mirtazapine49 44 1112.9HTR3A, ADRA2A, SLC6A4
28fenfluramine28 44 1112.9CCK, SLC6A4, HTR3A
29benzodiazepine4410.8CCK, HTR3A, CCKAR
30ketanserin28 4411.8SLC6A4, HTR3A, HTR4
31doxepin44 28 49 1113.8SLC6A4, ADRA2A, ADRA2C
32gr 11380844 59 2812.8HTR3A, HTR4
33mosapride44 2811.8HTR4, HTR3A
34indole4410.8SLC6A4, HTR3A, HTR4
35sumatriptan44 28 59 49 11 2415.8GNB3, HTR3A, MLN
36ranitidine44 28 11 2413.8F2RL1, MLN, CCK
37prazosin44 28 49 1113.8ADRA2C, ADRA2A, HTR4
38aripiprazole28 49 44 11 2414.8ADRA2A, ADRA2C, HTR3A
39histamine44 28 2412.7DEFB4A, F2RL1, HTR3A, CCK, MLN
40acetylcholine44 49 28 11 2414.7MLN, F2RL1, HTR4, HTR3A, CCK
41ziprasidone49 28 44 1113.7HTR3A, ADRA2A, ADRA2C
42[3h]rx8210022810.7ADRA2C, ADRA2A
43atipamezole hydrochloride5910.7ADRA2A, ADRA2C
441,4-benzodiazepine4410.6CCK, CCKAR
45zacopride44 2811.6HTR4, HTR3A
46asperlicin4410.6CCK, CCKAR
47dexmedetomidine hydrochloride5910.5ADRA2A, ADRA2C
48em 5234410.5MLNR, MLN
49rx8210022810.4ADRA2C, ADRA2A
50arc-2392810.2ADRA2A, ADRA2C

GO Terms for genes affiliated with Irritable Bowel Syndrome

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Sources:
16Gene Ontology
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Cellular components related to Irritable Bowel Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:00588710.5HTR3A, HTR4, MLNR, F2RL1, SLC6A4, ADRA2A
2plasma membraneGO:00588610.2LY96, KLB, CCKAR, S100A12, GNB3, HTR3A

Biological processes related to Irritable Bowel Syndrome according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1G-protein coupled receptor signaling pathwayGO:00718610.8ADRA2C, GNB3, HTR4, MLNR, MLN, DEFB4A
2negative regulation of uterine smooth muscle contractionGO:07047310.8ADRA2C, ADRA2A
3activation of MAPK activity by adrenergic receptor signaling pathwayGO:07188310.7ADRA2A, ADRA2C
4epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathwayGO:03562510.7ADRA2C, ADRA2A
5digestionGO:00758610.7CCKAR, HTR3A, MLNR
6negative regulation of epinephrine secretionGO:03281110.7ADRA2C, ADRA2A
7negative regulation of norepinephrine secretionGO:01070010.7ADRA2C, ADRA2A
8serotonin receptor signaling pathwayGO:00721010.6HTR3A, HTR4
9inflammatory responseGO:00695410.6LY96, F2RL1, S100A12, CCL16
10energy reserve metabolic processGO:00611210.6GNB3, ADRA2A, ADRA2C
11regulation of sensory perception of painGO:05193010.5ADRA2C, CCK
12innate immune responseGO:04508710.5KLB, S100A12, DEFB4A, F2RL1, LY96
13activation of protein kinase B activityGO:03214810.4ADRA2C, ADRA2A
14ion transmembrane transportGO:03422010.2CLCN2, HTR3E, HTR3A

Molecular functions related to Irritable Bowel Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1epinephrine bindingGO:05137910.5ADRA2C, ADRA2A
2alpha2-adrenergic receptor activityGO:00493810.2ADRA2C, ADRA2A

Products for genes affiliated with Irritable Bowel Syndrome

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  • Antibodies
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  • Antibodies

Sources for Irritable Bowel Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet