IBD
MCID: IRR002
MIFTS: 65

Irritable Bowel Syndrome (IBD) malady

Rare diseases, Gastrointestinal diseases categories
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Summaries for Irritable Bowel Syndrome

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MedlinePlus:33 Irritable bowel syndrome (ibs) is a problem that affects the large intestine. it can cause abdominal cramping, bloating, and a change in bowel habits. some people with the disorder have constipation. some have diarrhea. others go back and forth between the two. although ibs can cause a great deal of discomfort, it does not harm the intestines. ibs is common. it affects about twice as many women as men and is most often found in people younger than 45 years. no one knows the exact cause of ibs. there is no specific test for it. your doctor may run tests to be sure you don't have other diseases. these tests may include stool sampling tests, blood tests, and x-rays. your doctor may also do a test called a sigmoidoscopy or colonoscopy. most people diagnosed with ibs can control their symptoms with diet, stress management, probiotics, and medicine. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary: Irritable Bowel Syndrome, also known as inflammatory bowel diseases, is related to dyspepsia and constipation. An important gene associated with Irritable Bowel Syndrome is MIR510 (microRNA 510), and among its related pathways are Ligand-gated ion channel transport and Integrin alphaIIb beta3 signaling. The drugs cromolyn sodium and cromolyn and the compounds 1,4-benzodiazepine and asperlicin have been mentioned in the context of this disorder. Affiliated tissues include colon, testes and kidney, and related mouse phenotypes are endocrine/exocrine gland and behavior/neurological.

Disease Ontology:8 A syndrome that is a functional bowel disorder characterized by chronic abdominal pain, discomfort, bloating, and alteration of bowel habits in the absence of any detectable organic cause.

Wikipedia:65 Irritable bowel syndrome (IBS) or spastic colon is a symptom-based diagnosis characterized by chronic... more...

Aliases & Classifications for Irritable Bowel Syndrome

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Irritable Bowel Syndrome, Aliases & Descriptions:

Name: Irritable Bowel Syndrome 8 42 10 33 62
Inflammatory Bowel Diseases 62
 
Irritable Colon 8
Ibd 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Gastrointestinal diseases


External Ids:

Disease Ontology8 DOID:9778
NCIt39 C82343
ICD9CM27 564.1
MeSH34 D043183
ICD1025 K58, K58.0, K58.9

Related Diseases for Irritable Bowel Syndrome

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Diseases related to Irritable Bowel Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 149)
idRelated DiseaseScoreTop Affiliating Genes
1dyspepsia31.9HTR3A, CCK
2constipation31.5HTR3A, SLC6A4, CCK
3gastroesophageal reflux disease31.2CCKAR, CCK
4fibromyalgia31.0SLC6A4, HTR3A
5anxiety disorder30.8HTR3A, SLC6A4
6generalized anxiety disorder30.8SLC6A4, HTR3A
7premature ejaculation30.6SLC6A4
8gallbladder disease30.5CCKAR, CCK
9panic disorder30.4CCK, CCKAR, SLC6A4, HTR3A
10bulimia nervosa30.2HTR3A, SLC6A4, CCK
11diarrhea11.0
12colitis10.8
13inflammatory bowel disease10.8
14lactose intolerance10.7
15blindness10.7
16ulcerative colitis10.6
17gastroenteritis10.6
18microscopic colitis10.6
19celiac disease10.5
20motion sickness10.5HTR3A
21serotonin syndrome10.5HTR3A
22syndromic diarrhea10.4
23restless legs syndrome10.4
24functional diarrhea10.4
25infertility10.4
26diverticulitis10.4
27dysentery10.4
28endometriosis10.4
29esophagitis10.4
30migraine10.4
31pelvic inflammatory disease10.4
32prostatitis10.4
33gastroparesis10.3HTR3A, CCK
34isobutyryl-coa dehydrogenase deficiency10.3
35crohn's disease10.3
36fecal incontinence10.3
37osteoporosis10.3
38agoraphobia10.3
39somatization disorder10.3
40giardiasis10.3
41neuronitis10.3
42chronic fatigue syndrome10.3
43duodenitis10.3
44pancreas disease10.3CCK, CCKAR
45gastrointestinal system disease10.3CCKAR, CCK
46seasonal affective disorder10.3SLC6A4
47eating disorder10.2SLC6A4
48primary sclerosing cholangitis10.2
49pain agnosia10.2CCK, CCKAR, HTR3A
50thyroid medullary carcinoma10.2CCKAR, CCK

Graphical network of the top 20 diseases related to Irritable Bowel Syndrome:



Diseases related to irritable bowel syndrome

Symptoms for Irritable Bowel Syndrome

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Drugs & Therapeutics for Irritable Bowel Syndrome

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Genetic Tests for Irritable Bowel Syndrome

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Anatomical Context for Irritable Bowel Syndrome

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MalaCards organs/tissues related to Irritable Bowel Syndrome:

32
Colon, Testes, Kidney, Brain, Small intestine, Prostate, Cortex, Heart, Pituitary, Bone, Cerebellum, Liver, Breast, Prefrontal cortex, Amygdala, Neutrophil

Animal Models for Irritable Bowel Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Irritable Bowel Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.3CLCN2, CCK, CCKAR, HTR3A, SLC6A4
2MP:00053867.4CLCN2, ADRA2A, ADRA2C, CCKAR, HTR3A, SLC6A4
3MP:00053767.3CLCN2, ADRA2A, ADRA2C, CCK, CCKAR, HTR3A
4MP:00036316.9GNB3, CCKAR, HTR3A, SLC6A4, CCK, ADRA2C

Publications for Irritable Bowel Syndrome

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Articles related to Irritable Bowel Syndrome:

(show top 50)    (show all 788)
idTitleAuthorsYear
1
Clinical pilot study: efficacy of triple antibiotic therapy in Blastocystis positive irritable bowel syndrome patients. (25349629)
2014
2
Incidence and predictive factors of irritable bowel syndrome after acute diverticulitis in Korea. (25255851)
2014
3
Review article: linaclotide for the management of irritable bowel syndrome with constipation. (24433216)
2014
4
Faecal microbiota composition and host-microbe cross-talk following gastroenteritis and in postinfectious irritable bowel syndrome. (24310267)
2013
5
Effect of Ramosetron on Stool Consistency in Male Patients With Irritable Bowel Syndrome With Diarrhea. (24315882)
2013
6
Diffusion tensor imaging detects microstructural reorganization in the brain associated with chronic irritable bowel syndrome. (23721972)
2013
7
Irritable bowel syndrome-type symptoms in female patients with mild systemic lupus erythematosus: frequency, related factors and quality of life. (24112121)
2013
8
Gastrointestinal permeability in patients with irritable bowel syndrome assessed using a four probe permeability solution. (23328210)
2013
9
Irritable bowel syndrome in women. (23279011)
2013
10
Linaclotide: a novel compound for the treatment of irritable bowel syndrome with constipation. (24007408)
2013
11
Metabolic and toxicological considerations for the latest drugs used to treat irritable bowel syndrome. (23330973)
2013
12
Comparison of Manning, Rome I, II, and III, and Asian diagnostic criteria: report of the Multicentric Indian Irritable Bowel Syndrome (MIIBS) study. (23999682)
2013
13
Linaclotide-a novel secretagogue in the treatment of irritable bowel syndrome with constipation and chronic idiopathic constipation. (24001336)
2013
14
Effect of transcranial magnetic stimulation on rectal sensitivity in irritable bowel syndrome: a randomised, placebo-controlled pilot study. (24119239)
2013
15
Hypnotherapy: first line treatment for children with irritable bowel syndrome? (23456974)
2013
16
It is time to plan further researches on altered nutrient-sensing in irritable bowel syndrome. (23148699)
2013
17
Update on irritable bowel syndrome program of research. (24351989)
2013
18
Polymorphisms: Genetic variations associated with irritable bowel syndrome. (24206546)
2013
19
Association between irritable bowel syndrome and colorectal cancer: A nationwide population-based study. (24268837)
2013
20
How patients with long-term experience of living with irritable bowel syndrome manage illness in daily life: a qualitative study. (24047860)
2013
21
Rifaximin in the treatment of irritable bowel syndrome: is there a high risk for development of antimicrobial resistance? (23340064)
2013
22
Linaclotide, novel therapy for the treatment of chronic idiopathic constipation and constipation-predominant irritable bowel syndrome. (23436110)
2013
23
Cognitive-behavioral therapy for the management of irritable bowel syndrome. (24379577)
2013
24
Association between irritable bowel syndrome and restless legs syndrome in the general population. (22463600)
2012
25
What is irritable bowel syndrome? (23152730)
2012
26
Is There Enough Evidence for the Association of GNI^3 C825T Polymorphism With Functional Dyspepsia and Irritable Bowel Syndrome? (22837889)
2012
27
The global perspective on irritable bowel syndrome: a Rome Foundation-World Gastroenterology Organisation symposium. (23160283)
2012
28
An Update on Post-infectious Irritable Bowel Syndrome: Role of Genetics, Immune Activation, Serotonin and Altered Microbiome. (22837873)
2012
29
Targeted therapies for diarrhea-predominant irritable bowel syndrome. (22754282)
2012
30
Lactase persistence/non-persistence genetic variants in irritable bowel syndrome in an endemic area for lactose malabsorption. (22989008)
2012
31
Is There Enough Evidence for the Association of GNI^3 C825T Polymorphism With Functional Dyspepsia and Irritable Bowel Syndrome?: Author's Reply. (22837890)
2012
32
Functional dyspepsia: subtypes, risk factors, and overlap with irritable bowel syndrome in a population of african patients. (23213327)
2012
33
Irritable bowel syndrome and the elusive mast cells. (22552242)
2012
34
New paradigm for studying genetic contributions to irritable bowel syndrome. (22926498)
2012
35
Irritable bowel syndrome: physicians' awareness and patients' experience. (22851864)
2012
36
Colonic expression of Runx3 protein and TGF-I^(1) and their correlation in patients with irritable bowel syndrome. (21803306)
2011
37
Serum correlates of the placebo effect in irritable bowel syndrome. (20028464)
2010
38
Increased proteasome-mediated degradation of occludin in irritable bowel syndrome. (19997094)
2010
39
Chenodeoxycholate in females with irritable bowel syndrome-constipation: a pharmacodynamic and pharmacogenetic analysis. (20691689)
2010
40
Genetic determination of irritable bowel syndrome. (19034965)
2008
41
Development of functional diarrhea, constipation, irritable bowel syndrome, and dyspepsia during and after traveling outside the USA. (17549631)
2008
42
Characterization of autonomic dysfunction in patients with irritable bowel syndrome using fingertip blood flow. (18248583)
2008
43
Serotonin transporter gene polymorphism and irritable bowel syndrome. (17040410)
2006
44
CRF1 receptor signaling pathways are involved in stress-related alterations of colonic function and viscerosensitivity: implications for irritable bowel syndrome. (15100165)
2004
45
Altered visceral perceptual and neuroendocrine response in patients with irritable bowel syndrome during mental stress. (15247175)
2004
46
Interleukin 10 genotypes in irritable bowel syndrome: evidence for an inflammatory component? (12477767)
2003
47
Irritable bowel syndrome. Survey of definitions, differential diagnosis and pathogenesis]. (11475255)
2001
48
Irritable bowel syndrome: new agents targeting serotonin receptor subtypes. (11293643)
2001
49
Inhibition of gastric secretion relieves diarrhea and postprandial urgency associated with irritable bowel syndrome or functional diarrhea. (10505731)
1999
50
Cholecystokinin's role in regulation of colonic motility in health and in irritable bowel syndrome. (1587408)
1992

Variations for Irritable Bowel Syndrome

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Expression for genes affiliated with Irritable Bowel Syndrome

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Expression patterns in normal tissues for genes affiliated with Irritable Bowel Syndrome

Search GEO for disease gene expression data for Irritable Bowel Syndrome.

Pathways for genes affiliated with Irritable Bowel Syndrome

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Pathways related to Irritable Bowel Syndrome according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6HTR3A, HTR3E
2
Show member pathways
9.5ADRA2A, ADRA2C
3
Show member pathways
9.5ADRA2A, ADRA2C
49.5ADRA2A, ADRA2C
59.4SLC6A4, HTR3A
6
Show member pathways
9.2CCK, GNB3, CCKAR
7
Show member pathways
9.2CLCN2, HTR3A, HTR3E
8
Show member pathways
9.0ADRA2A, GNB3, ADRA2C
9
Show member pathways
9.0ADRA2C, GNB3, ADRA2A
10
Show member pathways
9.0GNB3, ADRA2A, ADRA2C
11
Show member pathways
Apoptosis and survival BAD phosphorylation60
Development Alpha 2 adrenergic receptor activation of ERK60
Chemotaxis CXCR4 signaling pathway60
9.0ADRA2C, ADRA2A, GNB3
128.8HTR3A, SLC6A4, GNB3
13
Show member pathways
8.7HTR3E, HTR3A, CLCN2, GNB3
14
Show member pathways
8.7GNB3, ADRA2C, ADRA2A, CLCN2
15
Show member pathways
8.3ADRA2A, CCKAR, CCK, ADRA2C, GNB3
16
Show member pathways
8.3CCKAR, CCK, ADRA2C, GNB3, ADRA2A
17
Show member pathways
8.2HTR3E, SLC6A4, GNB3, HTR3A

Compounds for genes affiliated with Irritable Bowel Syndrome

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Compounds related to Irritable Bowel Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 122)
idCompoundScoreTop Affiliating Genes
11,4-benzodiazepine4410.1CCK, CCKAR
2asperlicin4410.1CCKAR, CCK
3l3652604410.0CCK, CCKAR
4ym0224410.0CCK, CCKAR
5lorglumide44 2810.9CCKAR, CCK
6atipamezole hydrochloride619.9ADRA2C, ADRA2A
7dexmedetomidine hydrochloride619.9ADRA2A, ADRA2C
8dexloxiglumide44 2810.9HTR3A, CCK, CCKAR
9jp 1302 dihydrochloride619.9ADRA2C, ADRA2A
10benzodiazepines449.9CCKAR, HTR3A, CCK
11brl 44408289.9ADRA2C, ADRA2A
12arc-239289.9ADRA2A, ADRA2C
13rx821002289.9ADRA2A, ADRA2C
14benzodiazepine449.9CCK, HTR3A, CCKAR
15[3h]rx821002289.9ADRA2A, ADRA2C
16[3h]mk-912289.8ADRA2A, ADRA2C
17brl 44408 maleate619.8ADRA2A, ADRA2C
18medetomidine hydrochloride619.8ADRA2A, ADRA2C
19devazepide44 61 2811.8CCKAR, CCK
20omeprazole44 50 28 24 1113.8CCKAR, CCK, CLCN2
21[3h]rauwolscine289.7ADRA2C, ADRA2A
22xylazine44 2810.7ADRA2A, ADRA2C
23aripiprazole28 44 50 24 1113.6ADRA2A, ADRA2C, HTR3A
24ziprasidone28 50 44 1112.6ADRA2C, ADRA2A, HTR3A
25yohimbine44 2 28 1112.6HTR3A, ADRA2A, ADRA2C
26chlorpromazine28 44 50 1112.6ADRA2A, ADRA2C, HTR3A
27tetrodotoxin44 61 2811.6HTR3A, CCKAR, CCK
28ondansetron hydrochloride619.6HTR3A, HTR3E
29sr 57227 hydrochloride619.6HTR3A, HTR3E
30granisetron hydrochloride619.5HTR3E, HTR3A
31alosetron44 1110.4SLC6A4, HTR3A, CCK
32tegaserod44 28 1111.4CCK, SLC6A4, HTR3A
33fenfluramine44 28 1111.4HTR3A, CCK, SLC6A4
34tropisetron hydrochloride619.3HTR3A, HTR3E
35nefazodone44 50 1111.3ADRA2A, HTR3A, SLC6A4
36mianserin44 28 1111.2SLC6A4, ADRA2A, HTR3A
37mirtazapine44 50 1111.2ADRA2A, SLC6A4, HTR3A
38amitriptyline44 28 50 1112.2HTR3A, ADRA2A, SLC6A4
39doxepin44 28 50 1112.1ADRA2C, ADRA2A, SLC6A4
40fluoxetine44 50 28 1112.1GNB3, HTR3A, SLC6A4
41ondansetron50 44 24 1112.1CCK, HTR3A, CCKAR, SLC6A4
42gaba449.0HTR3A, CCK, CCKAR, SLC6A4
43methamphetamine44 50 1111.0SLC6A4, ADRA2A, ADRA2C
44quetiapine44 50 28 24 1112.9HTR3A, ADRA2A, ADRA2C, SLC6A4
45risperidone44 50 28 61 24 1113.9HTR3A, ADRA2A, ADRA2C, SLC6A4
46clonidine44 50 28 1111.6ADRA2A, ADRA2C, GNB3, SLC6A4
47olanzapine44 50 28 24 1112.3SLC6A4, ADRA2A, ADRA2C, HTR3A, GNB3
48clozapine44 28 50 1111.3ADRA2C, GNB3, HTR3A, SLC6A4, ADRA2A
49norepinephrine44 24 1110.0ADRA2C, HTR3A, ADRA2A, GNB3, SLC6A4, CCK
50dopamine44 28 24 1110.6SLC6A4, GNB3, ADRA2A, ADRA2C, CCK, CCKAR

GO Terms for genes affiliated with Irritable Bowel Syndrome

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Cellular components related to Irritable Bowel Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058877.6ADRA2A, ADRA2C, CCKAR, HTR3A, SLC6A4, TNFSF15
2plasma membraneGO:0058865.8SLC6A4, GNB3, TNFSF15, CLCN2, ADRA2A, ADRA2C

Biological processes related to Irritable Bowel Syndrome according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1digestionGO:0075869.8CCKAR, HTR3A
2negative regulation of uterine smooth muscle contractionGO:0704739.8ADRA2A, ADRA2C
3activation of MAPK activity by adrenergic receptor signaling pathwayGO:0718839.8ADRA2A, ADRA2C
4epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathwayGO:0356259.7ADRA2A, ADRA2C
5negative regulation of epinephrine secretionGO:0328119.7ADRA2A, ADRA2C
6negative regulation of norepinephrine secretionGO:0107009.7ADRA2C, ADRA2A
7regulation of sensory perception of painGO:0519309.6ADRA2C, CCK
8activation of protein kinase B activityGO:0321489.6ADRA2C, ADRA2A
9ion transmembrane transportGO:0342209.2CLCN2, HTR3E, HTR3A
10energy reserve metabolic processGO:0061129.1ADRA2A, GNB3, ADRA2C
11G-protein coupled receptor signaling pathwayGO:0071868.7ADRA2A, ADRA2C, GNB3

Molecular functions related to Irritable Bowel Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1epinephrine bindingGO:0513799.5ADRA2C, ADRA2A
2alpha2-adrenergic receptor activityGO:0049389.2ADRA2C, ADRA2A

Products for genes affiliated with Irritable Bowel Syndrome

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Sources for Irritable Bowel Syndrome

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3CDC
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25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
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40NDF-RT
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44Novoseek
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47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
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63UMLS via Orphanet