Irritable Bowel Syndrome malady

MedlinePlus: Irritable bowel syndrome (ibs) is a problem that affects the large intestine. it can cause abdominal cramping, bloating and a change in bowel habits. some people with the disorder have constipation. some have diarrhea. some go back and forth between constipation and diarrhea. although ibs can cause a great deal of discomfort, it does not harm the intestines. ibs is a common disorder and happens more often in women than men. no one knows the exact cause of ibs. there is no specific test for ibs. however, your doctor may run tests to be sure you don't have other diseases. these tests may include stool sampling tests, blood tests and x-rays. your doctor may also do a test called a sigmoidoscopy or colonoscopy. most people diagnosed with ibs can control their symptoms with diet, stress management and medicine. nih: national institute of diabetes and digestive and kidney diseases²³

MalaCards: Irritable Bowel Syndrome, also known as inflammatory bowel diseases, is related to constipation and crohn's disease. An important gene associated with Irritable Bowel Syndrome is MIR510 (microRNA 510), and among its related pathways are Ion channel transport and Glucocorticoid Pathway (HPA Axis), Pharmacodynamics. The drugs propantheline and propantheline bromide and the compounds carbachol and mirtazapine have been mentioned in the context of this disorder. Affiliated tissues include brain, small intestine and colon, and related mouse phenotypes are respiratory system and hematopoietic system.

Disease Ontology: A syndrome that is a functional bowel disorder characterized by chronic abdominal pain, discomfort, bloating, and alteration of bowel habits in the absence of any detectable organic cause.⁶

Wikipedia: Irritable bowel syndrome (IBS, or spastic colon) is a symptom-based diagnosis characterized by chronic...⁴⁴ more...

Aliases & Descriptions:

irritable bowel syndrome 6 8 23 43 inflammatory bowel diseases 43

irritable colon 6 ibd 6

Diseases related to irritable bowel syndrome by text searches and GeneDecks gene sharing:

(show top 50)    (show all 879)

id	Related Disease	Score	Top Affiliating Genes
1	constipation	32.2	VIP, CLCN2, CHGA, ATP4A, ATP12A, MLN
2	crohn's disease	31.5	GCG, MPO, MLN, IL10, IL13, IL1RN
3	dyspepsia	30.7	ATP4A, ATP12A, CD79A, MLN, MLNR, IL1RN
4	tuberculosis	30.7	P2RX7, IL10, IL1RN, IL4, IFNG, TNF
5	panic disorder	30.6	CCK, CCKAR, HTR1A, HTR3A, PTK7, CRH
6	collagenous colitis	30.4	MPO, CD79A, CD40LG, LTF, EPX
7	ankylosing spondylitis	30.2	CD79A, CD40LG, IL1RN, TNF
8	iron deficiency anemia	30.0	GHRL, TNF, LTF, SOD1
9	proctitis	29.5	MPO, TNF, LTF, EPX
10	rheumatoid arthritis	29.2	IL10, IL1RN, IL2, TNF, PRL
11	klebsiella	28.5	MPO, CD79A, CD40LG, IL1RN, TNF, ELANE
12	thrombocytosis	28.4	CD79A, CD40LG, IL4, IL6, HMGCR
13	pancreatic diseases	28.2	CHGA, P2RX7, IL6, CCK, CCKAR, TNF
14	primary sclerosing cholangitis	27.8	MPO, CD79A, IL10, IL2, IL4, IL6
15	cholangitis	27.8	MPO, CD79A, CD40LG, IL10, IL2, IL4
16	ulcerative colitis	27.7	GCG, VIP, MPO, CD79A, FOS, MLN
17	sclerosing cholangitis	27.5	MPO, CD79A, CD40LG, IL10, IL2, IL4
18	diarrhea	27.4	KLB, GCG, VIP, CLCN2, CHGA, LCT
19	type 2 diabetes mellitus	27.4	GCG, LEP, IL6, CCK, CCKAR, HTR2A
20	sepsis	27.2	MPO, IL10, IL1RN, IL6, IDO1, F2R
21	familial mediterranean fever	27.0	LEP, IL10, IL1RN, IL6, IFNG, TNF
22	homocysteine	25.7	GCG, LEP, CD40LG, FOS, IL1RN, IL2
23	arthropathy	25.6	CD79A, IL10, IL1RN, IL2, IL4, IL6
24	osteoporosis	24.7	GCG, LEP, LCT, P2RX7, ATP4A, ATP12A
25	cytomegalovirus infection	24.5	MPO, CD40LG, IL10, IL1RN, IL2, IL4
26	thrombosis	24.5	LEP, CHGA, P2RX7, MPO, CD79A, CD40LG
27	immunodeficiency	24.4	VIP, S100A12, CD79A, CD40LG, IL10, IL13
28	systemic lupus erythematosus	24.4	VIP, MPO, CD79A, CD40LG, FOS, IL10
29	connective tissue disease	24.2	MPO, CD79A, CD40LG, IL10, IL2, IL4
30	eczema	24.1	VIP, MPO, CD79A, CD40LG, IL10, IL13
31	pemphigus	23.9	CD79A, CD40LG, IL10, IL1RN, IL2, IL4
32	twinning	23.9	GCG, SCN5A, LEP, CHGA, MPO, CD79A
33	measles	23.5	CD79A, CD40LG, IL10, IL13, IL1RN, IL2
34	primary biliary cirrhosis	23.5	LEP, MPO, CD79A, CD40LG, IL10, IL1RN
35	spondylitis	23.4	VIP, LEP, MPO, CD79A, CD40LG, ITGB7
36	viral hepatitis	23.3	LEP, MPO, CD40LG, IL10, IL2, IL4
37	polyposis	23.1	VIP, CHGA, MPO, CD79A, CD40LG, IL10
38	colon cancer	23.1	GCG, VIP, SCN5A, LEP, CHGA, CHRM3
39	common variable immunodeficiency	23.0	MPO, CD79A, CD40LG, IL10, IL1RN, IL2
40	celiac disease	22.2	LEP, LCT, CD79A, CD40LG, MLN, IL10
41	colorectal cancer	22.2	VPS72, VIP, LEP, CHGA, LCT, S100A10
42	aortic aneurysm	22.1	LEP, MPO, CD79A, CD40LG, IL10, IL1RN
43	hypoxia	22.0	VIP, LEP, CHGA, CHRM3, UCN3, LCT
44	insulin resistance	21.9	GCG, LEP, CHGA, MPO, CD40LG, FOS
45	colon carcinoma	21.4	VIP, LEP, CHGA, CHRM3, LCT, S100A12
46	duodenitis	21.0	GCG, VIP, LEP, CHGA, ATP4A, ATP12A
47	inflammatory bowel disease	20.1	GCG, VIP, LEP, CHGA, LCT, S100A12
48	anemia	20.0	LEP, CHGA, ATP4A, MPO, CD79A, CD40LG
49	fibrosis	20.0	VIP, CLCN2, SCN5A, LEP, CHGA, LCT
50	adenoma	19.2	GCG, VIP, LEP, CHGA, MPO, FOS

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 alosetron, alosetron hcl, calcium polycarbophil, clidinium, clidinium bromide, cromolyn, cromolyn sodium, hyoscyamine, hyoscyamine hydrobromide, hyoscyamine sulfate, polycarbophil calcium, propantheline, propantheline bromide, psyllium, psyllium hydrocolloid, psyllium hydrophilic mucilloid, psyllium mucilloid, psyllium seed coatings,blond, tegaserod, tegaserod maleate

MalaCards organs/tissues related to irritable bowel syndrome:

²²

MGI Mouse Phenotypes related to irritable bowel syndrome:

²⁵ (show all 23)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.0	NPR1, CRHR1, CRH, NTF3, PTK7, TPH2
2	hematopoietic system phenotype	MP:0005397	9.8	TGM2, RUNX3, LY96, EPX, IDO1, IGHE
3	renal/urinary system phenotype	MP:0005367	9.8	TRPV1, PTK7, TGM2, TAC1, OXT, GNRH1
4	no phenotypic analysis	MP:0003012	9.1	TPH2, SST, TGM2, POMC, RUNX3, TRPV1
5	endocrine/exocrine gland phenotype	MP:0005379	8.8	HTR2A, IFNG, CCKAR, AQP8, IL2, CD40LG
6	skeleton phenotype	MP:0005390	8.6	RUNX3, TACR1, PTK7, PYY, GNRH1, F2RL1
7	liver/biliary system phenotype	MP:0005370	8.1	SOD1, PRL, TRPV1, IFNG, CCKAR, IL6
8	digestive/alimentary phenotype	MP:0005381	7.9	HTR2A, F2R, GNRH1, GHRL, SST, TGFB1
9	integument phenotype	MP:0010771	7.7	TPH1, TPH2, CRH, TACR1, OXT, PRL
10	nervous system phenotype	MP:0003631	7.6	ADRA2A, ADRA2C, RUNX3, SLC6A4, POMC, HTR7
11	mortality/aging	MP:0010768	7.3	ELANE, CRHR1, NTF3, PTK7, TPH2, TGM2
12	adipose tissue phenotype	MP:0005375	7.2	TNF, PYY, CRHR2, TGFB1, POMC, RUNX3
13	normal phenotype	MP:0002873	7.0	SST, NTF3, CRH, CRHR1, ELANE, SLC18A1
14	growth/size phenotype	MP:0005378	6.4	TPH2, TPH1, TRPV1, GNRH1, F2R, HTR4
15	vision/eye phenotype	MP:0005391	6.3	F2R, TNF, PTK7, NTF3, CRHR2, TGFB1
16	muscle phenotype	MP:0005369	6.1	TNF, NTF3, TGFB1, SOD1, NPR1, SLC6A4
17	immune system phenotype	MP:0005387	6.0	NPR1, IL6, IL2, GUCY2C, FOS, ITGB7
18	reproductive system phenotype	MP:0005389	5.5	IDO1, GNRH1, TNF, COMT, TGFB1, OXT
19	tumorigenesis	MP:0002006	5.3	TRPV1, TNF, ELANE, TGFB1, TGM2, PRL
20	cardiovascular system phenotype	MP:0005385	4.3	ADRA2A, NTF3, PTK7, TNF, TPH2, TPH1
21	cellular phenotype	MP:0005384	3.8	TNF, TRPV1, GNRH1, F2RL1, F2R, IDO1
22	homeostasis/metabolism phenotype	MP:0005376	3.6	NPR1, NTF3, SST, PYY, TPH2, TPH1
23	behavior/neurological phenotype	MP:0005386	2.9	ADRB3, ADRA2C, CRH, NTF3, SST, PYY

Articles related to irritable bowel syndrome:

(show top 50)    (show all 138)

id	Title	Authors	Year	Affiliating Genes
1	The HTR3A polymorphism c. -42C>T is associated wit h amygdala responsiveness in patients with irritable bowel syndrome. (21420406)	Kilpatrick L.A.... Mayer E.A.	2011	HTR3A
2	A KlothoI^ variant mediates protein stability and asso ciates with colon transit in irritable bowel syndrome with diarrhea. (21396369)	Wong B.S.... Gores G.J.	2011	KLB
3	Impaired uptake of serotonin by platelets from patien ts with irritable bowel syndrome correlates with duodenal immune activation. (21315720)	Foley S.... Spiller R.C.	2011	SLC6A4
4	Elevated expression of c-fos in central nervous syste m correlates with visceral hypersensitivity in irritable bowel syndrome (IBS): a new target for IBS treatment. (21340718)	Zhang R.... Qian J.M.	2011	FOS
5	Association of alpha 2A adrenergic receptor gene (ADR Alpha2A) polymorphism with irritable bowel syndrome, microscopic and ulcerative colitis. (19833115)	Sikander A.... Singh K.	2010	ADRA2A
6	Serotonin transporter activity and serotonin concentr ation in platelets of patients with irritable bowel syndrome: effect of gender. (19997855)	Franke L.... MAPnnikes H.	2010	SLC6A4
7	5-HTTLPR and STin2 polymorphisms in the serotonin tra nsporter gene and irritable bowel syndrome: effect of bowel habit and sex. (19561511)	Niesler B.... Houghton L.A.	2010	SLC6A4
8	The Serotonin Transporter Polymorphism rs25531 Is Associated with Irritable Bowel Syndrome. (19125330)	Kohen R.... Heitkemper M.M.	2009	SLC6A4
9	Ghrelin in patients with irritable bowel syndrome. (19424595)	El-Salhy M.... Salmelid L.	2009	GHRL
10	The role of chromogranin A in irritable bowel syndrom e. (19565071)	Hausken T.	2009	CHGA
11	Serum leptin levels and irritable bowel syndrome: a n ew hypothesis. (19398923)	Semnani S.... Joshaghani H.	2009	LEP
12	Pathophysiological concepts of functional dyspepsia a nd irritable bowel syndrome future pharmacotherapy. (19894640)	Dobrek A.8.... Thor P.J.	2009	HTR4
13	Elevated human beta-defensin-2 levels indicate an activation of the innate immune system in patients with irritable bowel syndrome. (19174795)	Langhorst J.... Dobos G.J.	2009	LTF, DEFB4A
14	Tryptophan catabolism in females with irritable bowel syndrome: relationship to interferon-gamma, severity of symptoms and psychiatric co-morbidity. (18823288)	Fitzgerald P.... Dinan Timothy G.	2008	IFNG, IDO1
15	Genetic determination of irritable bowel syndrome. (19034965)	Hotoleanu C.... Dumitrascu D.L.	2008	CCKAR, GNB3
16	Renzapride: a new drug for the treatment of constipation in the irritable bowel syndrome. (18922103)	Scarpellini E.... Tack J.	2008	HTR4
17	Lubiprostone for chronic idiopathic constipation and irritable bowel syndrome with constipation. (19072397)	Saad R.... Chey W.D.	2008	CLCN2
18	Evidence of an enhanced central 5HT response in irritable bowel syndrome and in the rat maternal separation model. (18194152)	O'Mahony S.... Dinan T.G.	2008	PRL, SLC6A4, HTR1A
19	Candidate Genes and Sensory Functions in Health and Irritable Bowel Syndrome. (18511740)	Camilleri M.... Zinsmeister A.R.	2008	GNB3, ADRA2C, SLC6A4
20	Expression of human beta-defensin 2 and tumor necrosis factor-A in colonic mucosae of ulcerative colitis and diarrhea-predominant irritable bowel syndrome (18756966)	Li M.R.... Zhang Q.Y.	2008	TNF, DEFB4A
21	Relationship of SERT polymorphisms to depressive and anxiety symptoms in irritable bowel syndrome. (17909168)	Jarrett M.E.... Heitkemper M.M.	2007	SLC6A4
22	Role of corticotropin-releasing hormone in irritable bowel syndrome and intestinal inflammation. (17238026)	Fukudo S.	2007	CRHR1, CRH, CRHR2
23	Faecal S100A12 as a non-invasive marker distinguishing inflammatory bowel disease from irritable bowel syndrome. (17675327)	Kaiser T.... Foell D.	2007	S100A12
24	Pharmacoeconomics and outcome research on Irritable Bowel Syndrome review of findings using Tegaserod (16622489)	Ariza J.G.... Martinez J.A.	2006	HTR4
25	Hypothalamic-pituitary-gut axis dysregulation in irritable bowel syndrome: plasma cytokines as a potential biomarker? (16472586)	Dinan T.G.... Keeling P.W.	2006	IL6
26	Irritable bowel syndrome: recent and novel therapeutic approaches. (16789793)	Andresen V.... Camilleri M.	2006	NTF3, HTR3A, CCK
27	A controlled study of colonic immune activity and beta7+ blood T lymphocytes in patients with irritable bowel syndrome. (16234043)	Ohman L.... Sjovall H.	2005	ITGB7
28	Central cholecystokinin activity in irritable bowel syndrome, panic disorder, and healthy controls. (16046372)	Koszycki D.... Bradwejn J.	2005	PTK7, CCK
29	The effects of the 5-HT3 antagonist, alosetron, on br ain serotonin synthesis in patients with irritable bowel syndrome. (15787942)	Nakai A.... Kersey K.	2005	HTR3A
30	Effect of CCK-1 antagonist, dexloxiglumide, in female patients with irritable bowel syndrome: a pharmacodynamic and pharmacogenomic study. (15743365)	Cremonini F.... Zinsmeister A.R.	2005	CCK
31	Fecal leukocyte proteins in inflammatory bowel disease and irritable bowel syndrome. (15819166)	Silberer H.... Schmidt-Gayk H.	2005	MPO, LTF, ELANE
32	Tachykinin NK2 receptor antagonists for the treatment of irritable bowel syndrome. (15037522)	Lecci A.... Maggi C.A.	2004	TAC1, TACR2
33	Serotonin transporter gene polymorphism in healthy adults and patients with irritable bowel syndrome (14745247)	Lee D.Y.... Choi Y.C.	2004	SLC6A4
34	Bacillary dysentery as a causative factor of irritable bowel syndrome and its pathogenesis. (15247174)	Wang L.H.... Pan G.Z.	2004	ENO2
35	Elevated vasoactive intestinal peptide concentrations in patients with irritable bowel syndrome. (15387352)	Palsson O.S.... Whitehead W.E.	2004	VIP
36	Association of the -1438 G/A and 102 T/C polymorphism of the 5-Ht2A receptor gene with irritable bowel syndrome 5-Ht2A gene polymorphism in irritable bowel syndrome. (15232358)	Pata C.... Ulu O.	2004	HTR2A
37	Increased rectal mucosal expression of interleukin 1beta in recently acquired post-infectious irritable bowel syndrome. (12631663)	Gwee K.A.... Moochhala S.M.	2003	IL1RN
38	Interleukin 10 genotypes in irritable bowel syndrome: evidence for an inflammatory component? (12477767)	Gonsalkorale W.M.... Hutchinson I.V.	2003	IL10
39	Tegaserod: a novel, selective 5-HT4 receptor partial agonist for irritable bowel syndrome. (11831835)	Beglinger C.	2002	HTR4
40	Irritable bowel syndrome neuropharmacology. A review of approved and investigational compounds. (12184141)	Callahan M.J.	2002	TACR1
41	Food hypersensitivity and irritable bowel syndrome. (11284772)	Zar S.... Benson M.J.	2001	IGHE
42	Therapeutic approach to the patient with irritable bowel syndrome. (10588170)	Camilleri M.	1999	HTR3A
43	5-HT4 receptor antagonism in irritable bowel syndrome : effect of SB-207266-A on rectal sensitivity and small bowel transit. (10571599)	Houghton L.A.... Cooper S.M.	1999	HTR4
44	Impact of corticotropin-releasing hormone on gastrointestinal motility and adrenocorticotropic hormone in normal controls and patients with irritable bowel syndrome. (9691924)	Fukudo S.... Hongo M.	1998	CRH
45	Abnormal sphincter of Oddi response to cholecystokinin in postcholecystectomy syndrome patients with irritable bowel syndrome. The irritable sphincter. (7729279)	Evans P.R.... Kellow J.E.	1995	SOD1
46	Effect of a 5HT3-antagonist (ondansetron) on rectal s ensitivity and compliance in health and the irritable bowel syndrome. (8280823)	Hammer J.... Camilleri M.	1993	HTR3A
47	Role of gut hormones in irritable bowel syndrome (1287245)	Morise K.... Saito H.	1992	CCK
48	Selective 5-hydroxytryptamine type 3 receptor antagonism with ondansetron as treatment for diarrhea-predominant irritable bowel syndrome: a pilot study. (1434911)	Steadman C.J.... Zinsmeister A.R.	1992	HTR3A
49	Motility disorders in the irritable bowel syndrome. (2066153)	Lind C.D.	1991	CCK
50	Intestinal sensitivity disorders and irritable bowel syndrome (2210179)	Mei N.	1990	CCK

Genes related to irritable bowel syndrome according to GeneCards:

(show top 50)    (show all 90)

id	Symbol	Description	Score	GeneCards Section Context
1	MIR510	microRNA 510	11.0	Publications
2	AQP8	aquaporin 8	11.0	Publications
3	HTR3E	5-hydroxytryptamine (serotonin) receptor 3E, ionotropic	11.0	Publications
4	CLCN2	chloride channel, voltage-sensitive 2	11.0	Publications
5	HTR3A	5-hydroxytryptamine (serotonin) receptor 3A, ionotropic	11.0	Publications
6	MLNR	motilin receptor	11.0	Publications
7	HTR4	5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled	11.0	Publications
8	HTR3D	5-hydroxytryptamine (serotonin) receptor 3D, ionotropic	11.0
9	MLN	motilin	11.0	Publications
10	VPS72	vacuolar protein sorting 72 homolog (S. cerevisiae)	11.0
11	ADRA2C	adrenoceptor alpha 2C	11.0	Publications
12	S100A10	S100 calcium binding protein A10	11.0	Publications
13	KLB	klotho beta	11.0	Publications
14	CCK	cholecystokinin	11.0	Publications
15	S100A12	S100 calcium binding protein A12	11.0	Publications
16	SLC6A4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	11.0	Publications
17	TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	11.0	Publications
18	GNB3	guanine nucleotide binding protein (G protein), beta polypeptide 3	11.0	Publications
19	OR2B2	olfactory receptor, family 2, subfamily B, member 2	11.0	Disorders
20	UCN3	urocortin 3 (stresscopin)	11.0
21	ADRA2A	adrenoceptor alpha 2A	11.0	Publications
22	PARM1	prostate androgen-regulated mucin-like protein 1	11.0
23	ATP4A	ATPase, H+/K+ exchanging, alpha polypeptide	11.0
24	CCKAR	cholecystokinin A receptor	11.0	Publications
25	ITGB7	integrin, beta 7	11.0	Publications
26	ITM2B	integral membrane protein 2B	11.0
27	LY96	lymphocyte antigen 96	11.0	Publications
28	HTR7	5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled	11.0	Publications
29	SLC18A1	solute carrier family 18 (vesicular monoamine), member 1	11.0	Publications
30	DEFB4A	defensin, beta 4A	11.0	Publications
31	PRSS3	protease, serine, 3	11.0	Publications
32	EPX	eosinophil peroxidase	11.0	Publications
33	TPH1	tryptophan hydroxylase 1	11.0	Publications
34	HTR3B	5-hydroxytryptamine (serotonin) receptor 3B, ionotropic	11.0
35	NPR1	natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)	11.0
36	PTK7	PTK7 protein tyrosine kinase 7	11.0	Publications
37	RUNX3	runt-related transcription factor 3	11.0	Publications
38	TACR2	tachykinin receptor 2	11.0	Publications
39	ATP12A	ATPase, H+/K+ transporting, nongastric, alpha polypeptide	11.0
40	CRHR2	corticotropin releasing hormone receptor 2	11.0	Publications
41	F2RL1	coagulation factor II (thrombin) receptor-like 1	11.0	Publications
42	CRHR1	corticotropin releasing hormone receptor 1	11.0	Publications
43	P2RX7	purinergic receptor P2X, ligand-gated ion channel, 7	11.0	Publications
44	TAC1	tachykinin, precursor 1	11.0	Publications
45	CHGA	chromogranin A (parathyroid secretory protein 1)	11.0	Publications
46	LTF	lactotransferrin	11.0	Publications
47	ADRB3	adrenoceptor beta 3	11.0	Publications
48	IDO1	indoleamine 2,3-dioxygenase 1	11.0	Publications
49	CRH	corticotropin releasing hormone	11.0	Publications
50	NTF3	neurotrophin 3	11.0	Publications

Pathways related to irritable bowel syndrome according to GeneDecks:

(show top 50)    (show all 71)

id	Pathway	Score	Top Affiliating Genes
1	Ion channel transport38	10.7	HTR3E, HTR3D, HTR3B, HTR3A
2	Glucocorticoid Pathway (HPA Axis), Pharmacodynamics34	10.5	POMC, CRHR2, CRHR1, CRH, UCN3
3	Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics34	10.5	SLC6A4, TPH2, TPH1, HTR4, HTR2A, HTR1A
4	Amine ligand-binding receptors38	10.4	ADRA2A, ADRA2C, HTR7, HTR4, HTR2A, HTR1A
5	OX40 Pathway36	10.2	IL5, IL4, IL13
6	Calcium signaling pathway20	10.1	ADRB3, TACR2, TACR1, F2R, HTR7, HTR4
7	G alpha (q) signalling events38	10.0	OXT, TACR2, TAC1, TACR1, GHRL, GNRH1
8	CRHR Pathway36	10.0	NPR1, POMC, CRHR2, CRHR1, CRH, GNB3
9	Selected targets of CREB110	9.8	CRH, HMGCR, CCK, IL13, CHGA, GCG
10	Immune System38	9.8	PRSS3, DEFB4A, IFNG, IL5, ITGB7, CD79A
11	IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.1	TGFB1, IL6, IL5, IL4, IL13
12	Neuroactive ligand-receptor interaction20	8.8	LEP, CRHR1, CRHR2, TACR1, TACR2, PRSS3
13	Asthma20	8.8	EPX, TNF, IL5, IL4, IL13, IL10
14	African trypanosomiasis20	8.6	TNF, F2RL1, IDO1, IFNG, IL6, IL10
15	eNOS Signaling36	8.6	NPR1, TGFB1, NTF3, PTK7, GNRH1, GNB3
16	Jak-STAT signaling pathway20	8.5	PRL, IL5, IL4, IL2, IL13, IL10
17	Activation of PKA through GPCR36	8.5	ADRA2A, ADRB3, ADRA2C, TGFB1, NTF3, PTK7
18	Endothelin-1 Signaling Pathway36	8.4	PTK7, IL6, IL5, IL4, IL2, IL13
19	cAMP Pathway36	8.4	CRHR1, CRHR2, TGFB1, ADRA2C, ADRB3, ADRA2A
20	Activation of cAMP-Dependent PKA36	8.4	CRHR1, CRHR2, TGFB1, ADRA2C, ADRB3, ADRA2A
21	Regulation of eIF4 and p70S6K36	8.4	NTF3, IL6, IL5, IL4, IL2, IL13
22	p70S6K Signaling36	8.3	TGFB1, NTF3, GNRH1, GNB3, F2RL1, F2R
23	Intestinal immune network for IgA production20	8.2	TGFB1, IL6, IL5, IL4, IL2, IL10
24	IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types37	8.2	TGFB1, TNF, IL2, IL10
25	Rho Family GTPases36	8.2	TGFB1, NTF3, PTK7, GNRH1, GNB3, IL4
26	Akt Signaling36	8.2	NTF3, PTK7, TNF, GNB3, IL6, IL4
27	THC Differentiation Pathway36	8.2	TNF, IFNG, IL4, IL2, IL10
28	Intracellular Calcium Signaling36	8.1	HTR7, GNB3, GNRH1, TRPV1, PTK7, NTF3
29	Allograft rejection20	8.0	TNF, IFNG, IL5, IL4, IL2, IL10
30	Immune response_MIF-mediated glucocorticoid regulation41	8.0	TNF, IFNG, IL6, IL2, FOS
31	Immune response MIF-mediated glucocorticoid regulation10	8.0	TNF, IFNG, IL6, IL2, FOS
32	Malaria20	8.0	TGFB1, TNF, IFNG, IL6, IL10, CD40LG
33	Leishmaniasis20	8.0	TGFB1, TNF, IFNG, IL4, IL10, FOS
34	ERK Signaling36	7.9	TGFB1, PTK7, GNRH1, IL6, IL5, IL4
35	MIF Mediated Glucocorticoid Regulation36	7.8	LY96, TNF, IL6, IL5, IL4, IL2
36	T cell receptor signaling pathway20	7.7	TNF, IFNG, IL5, IL4, IL2, IL10
37	Molecular Mechanisms of Cancer36	7.7	TGFB1, NTF3, PTK7, GNRH1, GNB3, IL6
38	TGF-Beta Pathway36	7.6	TGFB1, NTF3, GNRH1, IL6, IL5, IL4
39	MIF Regulation of Innate Immune Cells36	7.5	LY96, TNF, IL6, IL5, IL4, IL2
40	PEDF Induced Signaling36	7.5	TNF, IL6, IL5, IL4, IL2, IL13
41	Cytokine Network36	7.5	TNF, IFNG, IL6, IL5, IL4, IL2
42	Glucocorticoid Receptor Signaling36	7.5	IL6, IL5, IL4, IL2, IL13, IL10
43	Chagas disease (American trypanosomiasis)20	7.2	TGFB1, TNF, IFNG, IL6, IL2, IL10
44	MAPK Family Pathway36	7.0	GNRH1, TNF, NTF3, TGFB1, GNB3, IL6
45	PAK Pathway36	6.9	TGFB1, NTF3, TNF, GNRH1, IL6, IL5
46	p38 Signaling36	6.9	GNRH1, TNF, PTK7, NTF3, TGFB1, GNB3
47	Tec Kinases Signaling36	6.7	TGFB1, NTF3, TNF, GNRH1, GNB3, IL6
48	JAK-STAT Pathway36	6.7	F2R, GNRH1, PTK7, NTF3, TGFB1, PRL
49	Antioxidant Action of Vitamin-C36	6.1	TGFB1, NTF3, TNF, GNRH1, IL6, IL5
50	Cytokine-cytokine receptor interaction20	6.0	PRL, TGFB1, TNF, IFNG, IL6, IL5

Compounds related to irritable bowel syndrome according to GeneDecks:

(show top 50)    (show all 478)

id	Compound	Score	Top Affiliating Genes
1	carbachol32 9 9	12.4	GCG, TAC1, CRH, SST, F2RL1, CCK
2	mirtazapine32 34 9 9	12.8	ADRA2A, SLC6A4, POMC, PRL, CRH, TPH2
3	5-hydroxytryptophan32	9.7	HTR2A, HTR1A, CHGA, HTR3A, TPH1, SLC6A4
4	propranolol32 34 9 18 9	13.6	VIP, CHGA, MPO, ADRB3, TAC1, LTF
5	bromocriptine32 9 9	11.6	ADRA2A, ADRA2C, POMC, PRL, SST, GNRH1
6	l-nmma32	9.5	TAC1, TACR1, CRH, GHRL, IGHE, CCK
7	fenfluramine32 9 9	11.5	SLC6A4, POMC, PRL, CRH, TPH1, HTR3A
8	sodium nitroprusside32	9.5	NPR1, TAC1, TACR1, ELANE, CRH, SST
9	risperidone32 34 9 18 9	13.4	HTR3A, HTR2A, HTR1A, LEP, GHRL, COMT
10	tetrodotoxin32	9.3	CCK, ENO2, MLN, SCN5A, VIP, GCG
11	fluoxetine32 34 9 9	12.2	SLC6A4, PRL, OXT, TAC1, TACR1, CRHR1
12	paroxetine32 34 9 9	12.1	SLC6A4, PRL, TACR1, COMT, TPH1, GHRL
13	olanzapine32 34 9 18 9	13.0	PRL, COMT, GHRL, HTR7, HTR3A, HTR2A
14	corticosterone32 18	9.9	MPO, VIP, GCG, FOS, IL1RN, POMC
15	pge232	8.8	LTF, CRH, SST, TRPV1, F2RL1, F2R
16	isoproterenol32 9 9	10.8	SST, PYY, GNRH1, IGHE, IL5, IL13
17	clonidine32 9 9	10.7	LEP, CHGA, GNB3, ADRA2A, ADRA2C, SLC6A4
18	gaba32 42	9.7	GHRL, GNRH1, F2RL1, F2R, HTR3A, CCKAR
19	octreotide32 42 9 9	11.5	MLN, MPO, CHGA, VIP, GCG, ENO2
20	erythromycin32 9 9	10.4	GHRL, GNRH1, CCKAR, IL5, IL13, MLNR
21	methacholine32 9 9	10.3	VIP, OXT, TACR2, TAC1, TACR1, TGFB1
22	clozapine32 34 9 9	11.2	TACR1, GHRL, GNB3, F2RL1, HTR3A, HTR2A
23	calcium32 9 18 9	11.2	EPX, ADRA2A, PRSS3, DEFB4A, TACR2, TAC1
24	cocaine32 9 9	10.1	SLC6A4, POMC, PRL, COMT, CRHR1, CRH
25	naloxone32 34 9 9	11.0	POMC, PRL, OXT, TACR2, CRH, SST
26	acth32	7.9	CRHR1, VIP, CRH, SST, PTK7, PYY
27	heparin32 9 18 9	10.9	EPX, POMC, OXT, GCG, CHRM3, LCT
28	testosterone32 9 18 9	10.9	CRH, SST, GNRH1, IGHE, CCK, ENO2
29	alanine32	7.8	ADRB3, SLC6A4, NPR1, POMC, TACR2, TACR1
30	5-hydroxytryptamine32	7.8	MLN, CHGA, VIP, GCG, TPH1, GHRL
31	glutamate32	7.7	NTF3, GCG, VIP, SST, TRPV1, GNRH1
32	epinephrine32 9 18 9	10.5	GNB3, F2R, IGHE, IL1RN, CD79A, CHGA
33	vegf32	7.3	MPO, CHGA, VIP, GCG, OXT, TGFB1
34	estrogen32	7.1	POMC, PRL, OXT, DEFB4A, TAC1, ELANE
35	dopamine32 9 18 9	10.1	SST, FOS, CD40LG, CD79A, VIP, GCG
36	acetylcholine32 9 18 9	10.0	SLC18A1, POMC, TACR2, TAC1, TACR1, ELANE
37	neopterin32	6.9	ELANE, LTF, TNF, TPH1, IDO1, IFNG
38	pentoxifylline32 9 9	8.8	ELANE, LTF, TNF, GNRH1, IFNG, IL6
39	prednisolone32 9 9	8.5	POMC, TNF, IFNG, IGHE, IL6, IL5
40	adenylate32	6.2	CHRM3, CHGA, VIP, GCG, ADRA2A, HTR7
41	nitric oxide32 9 18 9	9.0	EPX, ADRB3, NPR1, SOD1, OXT, TACR2
42	tyrosine32	6.0	EPX, ADRA2A, ADRA2C, SLC18A1, DEFB4A, TAC1
43	arginine32	5.7	ADRB3, SLC6A4, POMC, SOD1, PRL, PRSS3
44	hydrocortisone32 9 9	7.4	POMC, PRL, ELANE, LTF, CRH, SST
45	lactate32	5.1	IGHE, ENO2, IL6, IL1RN, IL13, CD40LG
46	indomethacin32 9 9	6.6	TAC1, TACR1, TGFB1, LTF, CRH, TNF
47	cycloheximide32	4.2	IDO1, IFNG, IGHE, IL6, IL5, IL4
48	cyclosporin a32 42	4.6	POMC, TACR2, TGFB1, ELANE, LTF, TNF
49	histamine32 18	4.3	TAC1, TACR1, TGFB1, LTF, CRHR1, CRH
50	dexamethasone32 42 34 9 9	6.6	EPX, ADRB3, POMC, PRL, DEFB4A, TAC1

Cellular components related to irritable bowel syndrome according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	terminal button	GO:043195	10.2	P2RX7, CCK, CCKAR, OXT
2	axon	GO:030424	9.6	ADRA2C, TAC1, TGFB1, GHRL, HTR3B, HTR3A
3	secretory granule	GO:030141	9.4	POMC, OXT, ELANE, LTF, GHRL, MPO
4	neuronal cell body	GO:043025	9.1	SOD1, TAC1, TGFB1, SST, HTR3B, HTR3A
5	external side of plasma membrane	GO:009897	8.1	TNF, IFNG, IL4, IL13, CD40LG, CD79A
6	integral to plasma membrane	GO:005887	7.9	CHRM3, LCT, P2RX7, ATP4A, TNF, PTK7
7	plasma membrane	GO:005886	6.4	KLB, IL1RN, AQP8, ENO2, CCKAR, HTR1A
8	extracellular region	GO:005576	4.9	ELANE, LTF, CRH, NTF3, SST, PYY
9	extracellular space	GO:005615	4.1	IL10, CRH, TGFB1, TAC1, OXT, PRSS3

Biological processes related to irritable bowel syndrome according to GeneDecks:

(show all 49)

id	Name	GO ID	Score	Top Affiliating Genes
1	ion transmembrane transport	GO:034220	10.7	HTR3E, HTR3D, HTR3B, HTR3A, ATP12A, ATP4A
2	serotonin receptor signaling pathway	GO:007210	10.6	HTR4, HTR3A, HTR2A
3	tachykinin receptor signaling pathway	GO:007217	10.5	TACR2, TAC1, TACR1
4	sperm ejaculation	GO:042713	10.5	SLC6A4, OXT, TACR1
5	positive regulation of renal sodium excretion	GO:035815	10.5	NPR1, OXT, TAC1, TACR1
6	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	GO:007188	10.4	ADRB3, CRHR2, CRHR1, GCG
7	digestion	GO:007586	10.4	PRSS3, SST, PYY, HTR3A, CCKAR, MLNR
8	negative regulation of appetite	GO:032099	10.3	CCK, LEP, GCG
9	feeding behavior	GO:007631	10.3	CRH, PYY, CCKAR, GCG
10	regulation of sensory perception of pain	GO:051930	10.3	OXT, F2R, CCK, IL10
11	regulation of proton transport	GO:010155	10.3	IL4, IL13, ATP4A
12	positive regulation of synaptic transmission, cholinergic	GO:032224	10.2	TAC1, TACR1, IFNG
13	energy reserve metabolic process	GO:006112	10.1	ADRA2A, ADRB3, ADRA2C, GNB3, CHRM3, LEP
14	eating behavior	GO:042755	10.0	ADRB3, OXT, TACR1, PYY, CCK, LEP
15	B cell proliferation	GO:042100	10.0	CD79A, CD40LG, IL10
16	regulation of blood pressure	GO:008217	9.9	NPR1, POMC, SOD1, TAC1, GNB3, CHGA
17	response to organic cyclic compound	GO:014070	9.9	COMT, ENO2, IL4, IL1RN, ATP12A, P2RX7
18	response to lipopolysaccharide	GO:032496	9.8	LY96, TAC1, ELANE, COMT, F2R, IDO1
19	sensory perception of pain	GO:019233	9.7	TAC1, TACR1, HTR2A, P2RX7
20	synaptic transmission	GO:007268	9.7	TAC1, COMT, CRH, SST, GNB3, HTR7
21	response to nutrient	GO:007584	9.7	SST, HMGCR, CCKAR, IL4, LCT
22	positive regulation of MHC class II biosynthetic process	GO:045348	9.7	IFNG, IL4, IL10, CD40LG
23	response to ethanol	GO:045471	9.7	SOD1, TACR1, GNRH1, IL4, IL13, LCT
24	positive regulation of JAK-STAT cascade	GO:046427	9.7	PRL, F2R, IL6, IL5
25	positive regulation of MAPK cascade	GO:043410	9.6	LEP, P2RX7, IL6, F2R, ADRB3
26	G-protein coupled receptor signaling pathway	GO:007186	9.6	GCG, ADRA2A, ADRA2C, DEFB4A, CRHR1, SST
27	cell surface receptor signaling pathway	GO:007166	9.5	LY96, NPR1, PRL, SST, TRPV1, IFNG
28	elevation of cytosolic calcium ion concentration	GO:007204	9.5	OXT, TAC1, TACR1, GHRL, F2RL1, F2R
29	B cell differentiation	GO:030183	9.5	CD79A, CD40LG, IL10, IL4
30	positive regulation of isotype switching to IgG isotypes	GO:048304	9.5	IFNG, IL4, IL2
31	positive regulation of cytokine production	GO:001819	9.4	ADRA2A, SOD1, TNF, LEP
32	positive regulation of immunoglobulin secretion	GO:051024	9.4	IL6, IL5, IL2
33	response to activity	GO:014823	9.4	OXT, TNF, TPH2, IL10
34	positive regulation of B cell proliferation	GO:030890	9.3	IL5, IL4, IL2, IL13, CD40LG
35	positive regulation of chemokine biosynthetic process	GO:045080	9.2	IL4, IFNG, TNF
36	positive regulation of MAP kinase activity	GO:043406	9.1	HTR2A, TNF, ELANE, TGFB1, ADRA2A
37	negative regulation of growth of symbiont in host	GO:044130	9.1	ELANE, TNF, IFNG, IL10
38	positive regulation of smooth muscle cell proliferation	GO:048661	9.0	TGM2, ELANE, TNF, IL6, IL13
39	regulation of insulin secretion	GO:050796	9.0	ADRA2A, ADRA2C, TNF, IFNG, CHRM3, LEP
40	cell-cell signaling	GO:007267	8.9	ADRA2C, POMC, TAC1, NTF3, SST, PYY
41	platelet activation	GO:030168	8.9	ADRA2A, ADRA2C, SOD1, TGFB1, F2R, IL6
42	response to glucocorticoid stimulus	GO:051384	8.7	OXT, TNF, TPH2, CCKAR, IL6, IL1RN
43	humoral immune response	GO:006959	8.6	IL6, IFNG, TNF, LTF
44	positive regulation of sequence-specific DNA binding transcription factor activity	GO:051091	8.5	TNF, IL6, IL5, IL4, IL10
45	female pregnancy	GO:007565	8.4	PRL, OXT, TGFB1, COMT, CRHR1, CRH
46	positive regulation of cell proliferation	GO:008284	8.3	HTR2A, HTR4, F2R, TGFB1, ADRA2A, HTR1A
47	anti-apoptosis	GO:006916	8.2	SOD1, TNF, GHRL, GNRH1, IL2, IL10
48	response to drug	GO:042493	7.2	TNF, SST, COMT, TGFB1, SOD1, SLC6A4
49	inflammatory response	GO:006954	7.1	F2RL1, TNF, CRH, TGFB1, TACR1, TAC1

Molecular functions related to irritable bowel syndrome according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	serotonin receptor activity	GO:004993	10.2	HTR7, HTR4, HTR3B, HTR3A, HTR2A, HTR1A
2	serotonin binding	GO:051378	10.2	HTR1A, HTR2A, HTR3A
3	epinephrine binding	GO:051379	10.0	ADRA2C, ADRB3, ADRA2A
4	neuropeptide hormone activity	GO:005184	10.0	CRH, PYY, CCK, VIP
5	receptor binding	GO:005102	9.8	POMC, CRH, NTF3, F2RL1, F2R, MLN
6	hormone activity	GO:005179	8.9	GCG, POMC, PRL, CRHR2, CRH, SST
7	growth factor activity	GO:008083	7.6	TGFB1, NTF3, IL6, IL5, IL4, IL2
8	cytokine activity	GO:005125	6.9	TNF, IFNG, IL6, IL5, IL4, IL2