IBD
MCID: IRR002
MIFTS: 68

Irritable Bowel Syndrome (IBD) malady

Gastrointestinal diseases category

Summaries for Irritable Bowel Syndrome

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8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Irritable bowel syndrome (ibs) is a problem that affects the large intestine. it can cause abdominal cramping, bloating, and a change in bowel habits. some people with the disorder have constipation. some have diarrhea. others go back and forth between the two. although ibs can cause a great deal of discomfort, it does not harm the intestines. ibs is common. it affects about twice as many women as men and is most often found in people younger than 45 years. no one knows the exact cause of ibs. there is no specific test for it. your doctor may run tests to be sure you don't have other diseases. these tests may include stool sampling tests, blood tests, and x-rays. your doctor may also do a test called a sigmoidoscopy or colonoscopy. most people diagnosed with ibs can control their symptoms with diet, stress management, probiotics, and medicine. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Irritable Bowel Syndrome, also known as inflammatory bowel diseases, is related to constipation and diarrhea. An important gene associated with Irritable Bowel Syndrome is MIR510 (microRNA 510), and among its related pathways are SLC-mediated transmembrane transport and Circadian entrainment. The drugs cromolyn sodium and clidinium and the compounds dopamine and norepinephrine have been mentioned in the context of this disorder. Affiliated tissues include colon, testes and kidney, and related mouse phenotypes are behavior/neurological and endocrine/exocrine gland.

Disease Ontology:8 A syndrome that is a functional bowel disorder characterized by chronic abdominal pain, discomfort, bloating, and alteration of bowel habits in the absence of any detectable organic cause.

Wikipedia:63 Irritable bowel syndrome (IBS, or spastic colon) is a symptom-based diagnosis characterized by chronic... more...

Aliases & Classifications for Irritable Bowel Syndrome

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 39NCIt, 27ICD9CM, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

irritable bowel syndrome 8 42 10 33 60
inflammatory bowel diseases 60
irritable colon 8
ibd 8


External Ids:

Disease Ontology8 DOID:9778
NCIt39 C82343
ICD9CM27 564.1
MeSH34 D043183
ICD1025 K58, K58.0, K58.9

Related Diseases for Irritable Bowel Syndrome

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Irritable Bowel Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 356)
idRelated DiseaseScoreTop Affiliating Genes
1constipation31.4CCK, HTR3A, HTR4, MLN, SLC6A4
2diarrhea31.4HTR3A, MLN
3dyspepsia31.2HTR3A, CCK, MLNR, MLN
4inflammatory bowel disease31.1S100A12
5ulcerative colitis30.8MLN, DEFB4A, F2RL1, AQP8
6gastroesophageal reflux disease30.7MLN, CCK, CCKAR
7panic disorder30.6CCKAR, CCK, HTR3A, SLC6A4
8chronic fatigue syndrome30.6SLC6A4
9anxiety disorder30.6SLC6A4, HTR3A
10migraine30.5SLC6A4, HTR3A
11generalized anxiety disorder30.5SLC6A4, HTR3A
12diabetes mellitus30.3CCKAR, CCK, GNB3, MLN
13gastrointestinal system disease30.3CCKAR, CCK, HTR4, MLN
14mood disorder30.1ADRA2A, SLC6A4, HTR3A, GNB3
15bulimia nervosa30.1CCK, SLC6A4
16duodenogastric reflux30.1MLN, CCK
17premature ejaculation30.1SLC6A4
18alzheimer's disease30.1CCK, S100A12, SLC6A4
19gastritis30.0CCK, MLN, DEFB4A
20obesity30.0CCKAR, CCK, GNB3, MLN, ADRA2A
21duodenal ulcer30.0DEFB4A, CCK
22functional colonic disease30.0HTR4, MLNR
23cystic fibrosis30.0DEFB4A, CLCN2, F2RL1
24bipolar disorder30.0HTR3A, SLC6A4
25acute pancreatitis30.0CCKAR, CCK, F2RL1
26peptic ulcer30.0CCK
27gallbladder disease30.0CCKAR, CCK, MLNR, MLN
28syndromic diarrhea10.9
29chromosomal disease10.7
30lactose intolerance10.6
31hepatitis10.6
32vascular disease10.6
33skin disease10.6
34functional diarrhea10.6
35colon cancer10.6
36gastroenteritis10.5
37collagen disease10.5
38rectal disease10.5
39tuberculosis10.5
40celiac disease10.5
41adult syndrome10.5
42ankylosing spondylitis10.5
43hepatitis a10.5
44arthritis10.5
45spondylitis10.5
46spondyloarthropathy10.5
47hepatitis b10.4
48multiple sclerosis10.4
49restless legs syndrome10.4
50hyperhomocysteinemia10.4

Graphical network of the top 20 diseases related to Irritable Bowel Syndrome:



Diseases related to irritable bowel syndrome

Clinical Features for Irritable Bowel Syndrome

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Drugs & Therapeutics for Irritable Bowel Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Irritable Bowel Syndrome

Drug clinical trials:

Search ClinicalTrials for Irritable Bowel Syndrome

Search NIH Clinical Center for Irritable Bowel Syndrome

Highlights from CenterWatch's Drugs in Clinical Trials Database for Irritable Bowel Syndrome:

idCompanyCompoundMechanismPhase
1Lexicon PharmaceuticalsLX1033An orally-delivered small molecule that inhibits tryptophan hydroxylaseII
2Synergy PharmaceuticalsplecanatideA synthetic analog of uroguanylin a natriuretic hormone that regulates ion and fluid transport in the GI tract.IIb
3Furiex PharmaceuticalsMuDeltaA mu-opioid receptor agonist and delta-opioid receptor antagonistIII
4Salix PharmaceuticalsrifaximinA semisynthetic rifamycin derivative and non-systemic gastrointestinal site-specific broad spectrum antibioticIII
5Tioga PharmaceuticalsasimadolineA peripheral kappa-agonistIII

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Irritable Bowel Syndrome

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Anatomical Context for Irritable Bowel Syndrome

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32MalaCards
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MalaCards organs/tissues related to Irritable Bowel Syndrome:

32
Colon, Testes, Kidney, Brain, Small intestine, Prostate, Pituitary, Heart, Cortex, Liver, Breast, Cerebellum, Prefrontal cortex, Amygdala, Bone

Animal Models for Irritable Bowel Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Irritable Bowel Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538610.5CCKAR, HTR3A, HTR4, CLCN2, F2RL1, SLC6A4
2MP:000537910.5AQP8, KLB, CCKAR, CCK, HTR3A, CLCN2
3MP:000537610.4KLB, CCKAR, CCK, HTR3A, HTR4, CLCN2
4MP:000363110.2HTR3A, GNB3, CCK, CCKAR, HTR4, CLCN2

Publications for Irritable Bowel Syndrome

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Sources:
50PubMed
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Articles related to Irritable Bowel Syndrome:

(show top 50)    (show all 769)
idTitleAuthorsYear
1
It is time to plan further researches on altered nutrient-sensing in irritable bowel syndrome. (23148699)
2013
2
Update on irritable bowel syndrome program of research. (24351989)
2013
3
Linaclotide, novel therapy for the treatment of chronic idiopathic constipation and constipation-predominant irritable bowel syndrome. (23436110)
2013
4
Rome III functional constipation and irritable bowel syndrome with constipation are similar disorders within a spectrum of sensitization, regulated by serotonin. (23872499)
2013
5
Mast cell tryptase reduces junctional adhesion molecule-A (JAM-A) expression in intestinal epithelial cells: implications for the mechanisms of barrier dysfunction in irritable bowel syndrome. (23588236)
2013
6
The overlap in the genetic pathogenesis of ulcerative colitis and irritable bowel syndrome. (24233129)
2013
7
Adverse events appear to unblind clinical trials in irritable bowel syndrome. (24350975)
2013
8
A clinical observation of irritable bowel syndrome treated by traditional Chinese spinal orthopedic manipulation. (24280469)
2013
9
Changes in the modulation of spinal pain processing are related to severity in irritable bowel syndrome. (23551988)
2013
10
Treatment of Refractory Irritable Bowel Syndrome with Visceral Osteopathy: Short-Term and Long-Term Results of a Randomized Trial. (23981319)
2013
11
The low FODMAP diet improves gastrointestinal symptoms in patients with irritable bowel syndrome: a prospective study. (23701141)
2013
12
A randomised trial of ondansetron for the treatment of irritable bowel syndrome with diarrhoea. (24334242)
2013
13
Automatic functioning in irritable bowel syndrome as measured by heart rate variability: a meta-analysis. (23927739)
2013
14
The role of oxidants and reactive nitrogen species in irritable bowel syndrome: a potential etiological explanation. (24029778)
2013
15
IgG-based elimination diet in migraine plus irritable bowel syndrome. (23216231)
2013
16
Influence of tianeptine on melatonin homeostasis and psychosomatic symptoms in patients with irritable bowel syndrome. (23756392)
2013
17
Optimizing treatment for patients with irritable bowel syndrome with constipation. (23859753)
2013
18
A randomised controlled trial of a probiotic 'functional food' in the management of irritable bowel syndrome. (23496803)
2013
19
Long-term success of GUT-directed group hypnosis for patients with refractory irritable bowel syndrome: a randomized controlled trial. (23419384)
2013
20
Is There Enough Evidence for the Association of GNI^3 C825T Polymorphism With Functional Dyspepsia and Irritable Bowel Syndrome? (22837889)
2012
21
Efficacy of Solifenacin on Irritable Bowel Syndrome With Diarrhea: Open-label Prospective Pilot Trial. (22837880)
2012
22
IgG and IgG4 antibodies in subjects with irritable bowel syndrome: a case control study in the general population. (23170971)
2012
23
Increased proton pump inhibitor and NSAID exposure in irritable bowel syndrome: results from a case-control study. (22950677)
2012
24
Subtle mucosal changes at capsule endoscopy in diarrhoea predominant Irritable Bowel Syndrome. (22766519)
2012
25
Epidemiology of functional diarrhea and comparison with diarrhea-predominant irritable bowel syndrome: a population-based survey in China. (22937091)
2012
26
Virulence markers of Helicobacter pylori in patients with diarrhoea-dominant irritable bowel syndrome. (22558797)
2012
27
The Irritable Bowel Syndrome Outcome Study (IBSOS): rationale and design of a randomized, placebo-controlled trial with 12 month follow up of self- versus clinician-administered CBT for moderate to severe irritable bowel syndrome. (22846389)
2012
28
Treatment of irritable bowel syndrome: sex and gender specific aspects. (23027463)
2012
29
Risk of inflammatory bowel disease following a diagnosis of irritable bowel syndrome. (22639930)
2012
30
Fecal fat excretion in irritable bowel syndrome. (22746315)
2012
31
Chromogranin A cell density in the rectum of patients with irritable bowel syndrome. (22992886)
2012
32
Subtypes and Symptomatology of Irritable Bowel Syndrome in Children and Adolescents: A School-based Survey Using Rome III Criteria. (22837878)
2012
33
High frequency of chronic bacterial and non-inflammatory prostatitis in infertile patients with prostatitis syndrome plus irritable bowel syndrome. (21494624)
2011
34
An investigation of signal transduction pathway of colonic mucosal toll-like receptor 4 in patients with diarrhea-irritable bowel syndrome]. (20979736)
2010
35
G protein beta3 subunit, interleukin-10, and tumor necrosis factor-alpha gene polymorphisms in Koreans with irritable bowel syndrome. (20337945)
2010
36
The serotonin transporter polymorphism rs25531 is associated with irritable bowel syndrome. (19125330)
2009
37
Design and synthesis of piperazinylpyridine derivatives as novel 5-HT1A agonists/5-HT3 antagonists for the treatment of irritable bowel syndrome (IBS). (19122313)
2009
38
Ghrelin in patients with irritable bowel syndrome. (19424595)
2009
39
Management of irritable bowel syndrome. (19829284)
2009
40
Lactose intolerance in patients with irritable bowel syndrome from northern India: a case-control study. (17559357)
2007
41
Safety and tolerability of tegaserod in irritable bowel syndrome management. (14965152)
2004
42
Clinical and subclinical intestinal inflammation assessed by the mucosal patch technique: studies of mucosal neutrophil and eosinophil activation in inflammatory bowel diseases and irritable bowel syndrome. (15542519)
2004
43
Elevated vasoactive intestinal peptide concentrations in patients with irritable bowel syndrome. (15387352)
2004
44
Comorbidity of irritable bowel syndrome, panic disorder, and agoraphobia in a Japanese representative sample. (15046231)
2004
45
Breath testing to evaluate lactose intolerance in irritable bowel syndrome correlates with lactulose testing and may not reflect true lactose malabsorption. (14687820)
2003
46
Role of corticotropin releasing factor receptor subtype 1 in stress-related functional colonic alterations: implications in irritable bowel syndrome. (16144197)
2002
47
Irritable bowel syndrome: new agents targeting serotonin receptor subtypes. (11293643)
2001
48
Irritable bowel syndrome: new pharmaceutical approaches to treatment. (10580922)
1999
49
Metronidazole relieves symptoms in irritable bowel syndrome: the confusion with so-called 'chronic amebiasis'. (9357184)
1997
50
Irritable-bowel syndrome with lactose intolerance. (50523)
1975

Genetic Variations for Irritable Bowel Syndrome

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Expression for genes affiliated with Irritable Bowel Syndrome

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Irritable Bowel Syndrome

Search GEO for disease gene expression data for Irritable Bowel Syndrome.

Pathways for genes affiliated with Irritable Bowel Syndrome

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Sources:
53Reactome, 29KEGG, 37NCBI BioSystems Database, 49PharmGKB, 12EMD Millipore
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Pathways related to Irritable Bowel Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.5GNB3, HTR3A, HTR3E, CLCN2, AQP8
2
Hide members
10.5SLC6A4, HTR3E, HTR4, HTR3A, GNB3
3
Hide members
10.5KLB, CCL16, CCKAR, CCK, GNB3, HTR4
4
Hide members
10.5HTR3A, HTR4, SLC6A4, ADRA2A
5
Hide members
10.5CCKAR, CCK, GNB3, MLNR, MLN, F2RL1
6
Hide members
10.5ADRA2C, ADRA2A, GNB3
7
Hide members
10.5ADRA2A, CCL16, CCKAR, CCK, GNB3, HTR4
8
Hide members
10.5AQP8, ADRA2C, ADRA2A, GNB3
9
Hide members
10.5ADRA2A, ADRA2C

Compounds for genes affiliated with Irritable Bowel Syndrome

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB, 59Tocris Bioscience
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Compounds related to Irritable Bowel Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 123)
idCompoundScoreTop Affiliating Genes
1dopamine44 28 11 2414.0ADRA2C, CCKAR, CCK, GNB3, HTR3A, MLNR
2norepinephrine44 11 2413.0HTR3A, F2RL1, SLC6A4, ADRA2A, ADRA2C, GNB3
3clozapine44 28 49 1114.0HTR3A, GNB3, ADRA2C, SLC6A4, F2RL1, ADRA2A
4dexloxiglumide44 2811.9HTR3A, CCK, CCKAR, MLN
5tegaserod44 28 1112.9SLC6A4, MLN, HTR4, HTR3A, CCK
6benzodiazepines4410.9CCKAR, CCK, F2RL1, HTR3A
7ondansetron44 49 11 2413.9CCKAR, CCK, HTR3A, HTR4, MLN
85-hydroxytryptamine4410.9F2RL1, CCK, HTR3A, SLC6A4, MLN, HTR4
9cisapride44 28 1112.9MLN, MLNR, HTR4, CCK, HTR3A
10mianserin28 44 1112.9HTR4, SLC6A4, ADRA2A, HTR3A
11metoclopramide44 1111.9HTR3A, HTR4, MLN, CCK
12yohimbine44 28 2 1113.9HTR3A, HTR4, ADRA2A, ADRA2C
13omeprazole44 28 49 11 2414.9CCKAR, CLCN2, MLN, CCK
14alosetron44 1111.9HTR3A, CCK, SLC6A4
15risperidone28 44 49 59 11 2415.9ADRA2C, ADRA2A, SLC6A4, HTR3A
16caerulein4410.9CCK, CCKAR, MLN
17prucalopride44 2811.9MLN, HTR4, HTR3A
18clonidine44 28 1112.9GNB3, SLC6A4, ADRA2A, ADRA2C
19olanzapine49 44 28 11 2414.9ADRA2A, ADRA2C, GNB3, HTR3A
20granisetron44 1111.9CCK, HTR3A, HTR4
21Ephedra1110.9ADRA2C, ADRA2A, SLC6A4
22tetrodotoxin44 59 2812.9CCKAR, CCK, HTR3A, MLN
23octreotide44 59 28 1113.9F2RL1, MLN, CCK, CCKAR
24gaba4410.9CCKAR, F2RL1, CCK, SLC6A4, HTR3A
25nefazodone44 49 1112.9SLC6A4, ADRA2A, HTR3A
26atropine44 28 1112.9MLN, HTR4, CCKAR, CCK
27mirtazapine49 44 1112.9HTR3A, SLC6A4, ADRA2A
28fenfluramine28 44 1112.9CCK, HTR3A, SLC6A4
29benzodiazepine4410.8CCKAR, CCK, HTR3A
30ketanserin28 4411.8HTR3A, HTR4, SLC6A4
31doxepin44 28 49 1113.8ADRA2C, ADRA2A, SLC6A4
32mosapride44 2811.8HTR4, HTR3A
33gr 11380844 59 2812.8HTR4, HTR3A
34indole4410.8SLC6A4, HTR4, HTR3A
35ranitidine44 28 11 2413.8F2RL1, CCK, MLN
36sumatriptan44 28 59 49 11 2415.8MLN, GNB3, HTR3A
37prazosin44 28 49 1113.8ADRA2C, ADRA2A, HTR4
38aripiprazole28 49 44 11 2414.8ADRA2C, HTR3A, ADRA2A
39histamine44 28 2412.7F2RL1, CCK, DEFB4A, MLN, HTR3A
40acetylcholine44 49 28 11 2414.7F2RL1, MLN, HTR4, CCK, HTR3A
41ziprasidone49 28 44 1113.7HTR3A, ADRA2A, ADRA2C
42zacopride44 2811.7HTR3A, HTR4
43asperlicin4410.7CCK, CCKAR
441,4-benzodiazepine4410.6CCKAR, CCK
45jp 1302 dihydrochloride5910.6ADRA2C, ADRA2A
46medetomidine hydrochloride5910.6ADRA2C, ADRA2A
47brl 444082810.5ADRA2C, ADRA2A
48[3h]mk-9122810.5ADRA2C, ADRA2A
49[3h]rx8210022810.4ADRA2C, ADRA2A
50brl 44408 maleate5910.2ADRA2A, ADRA2C

GO Terms for genes affiliated with Irritable Bowel Syndrome

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16Gene Ontology
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Cellular components related to Irritable Bowel Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:00588710.5HTR3A, HTR4, MLNR, F2RL1, SLC6A4, ADRA2A
2plasma membraneGO:00588610.2LY96, KLB, CCKAR, S100A12, GNB3, HTR3A

Biological processes related to Irritable Bowel Syndrome according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1G-protein coupled receptor signaling pathwayGO:00718610.8ADRA2C, GNB3, HTR4, MLNR, MLN, DEFB4A
2negative regulation of uterine smooth muscle contractionGO:07047310.8ADRA2C, ADRA2A
3activation of MAPK activity by adrenergic receptor signaling pathwayGO:07188310.7ADRA2A, ADRA2C
4epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathwayGO:03562510.7ADRA2C, ADRA2A
5digestionGO:00758610.7CCKAR, HTR3A, MLNR
6negative regulation of epinephrine secretionGO:03281110.7ADRA2C, ADRA2A
7negative regulation of norepinephrine secretionGO:01070010.7ADRA2C, ADRA2A
8serotonin receptor signaling pathwayGO:00721010.6HTR3A, HTR4
9inflammatory responseGO:00695410.6LY96, F2RL1, S100A12, CCL16
10energy reserve metabolic processGO:00611210.6GNB3, ADRA2A, ADRA2C
11regulation of sensory perception of painGO:05193010.5ADRA2C, CCK
12innate immune responseGO:04508710.5KLB, S100A12, DEFB4A, F2RL1, LY96
13activation of protein kinase B activityGO:03214810.4ADRA2C, ADRA2A
14ion transmembrane transportGO:03422010.2CLCN2, HTR3E, HTR3A

Molecular functions related to Irritable Bowel Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1epinephrine bindingGO:05137910.5ADRA2C, ADRA2A
2alpha2-adrenergic receptor activityGO:00493810.2ADRA2C, ADRA2A

Products for genes affiliated with Irritable Bowel Syndrome

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  • Antibodies
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Sources for Irritable Bowel Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet