IBD
MCID: IRR002
MIFTS: 65

Irritable Bowel Syndrome (IBD) malady

Gastrointestinal category

Summaries for Irritable Bowel Syndrome

Sources:
8Disease Ontology, 34MedlinePlus, 64Wikipedia, 33MalaCards
See all sources

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MedlinePlus:34 Irritable bowel syndrome (ibs) is a problem that affects the large intestine. it can cause abdominal cramping, bloating, and a change in bowel habits. some people with the disorder have constipation. some have diarrhea. others go back and forth between the two. although ibs can cause a great deal of discomfort, it does not harm the intestines. ibs is common. it affects about twice as many women as men and is most often found in people younger than 45 years. no one knows the exact cause of ibs. there is no specific test for it. your doctor may run tests to be sure you don't have other diseases. these tests may include stool sampling tests, blood tests, and x-rays. your doctor may also do a test called a sigmoidoscopy or colonoscopy. most people diagnosed with ibs can control their symptoms with diet, stress management, probiotics, and medicine. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Irritable Bowel Syndrome, also known as inflammatory bowel diseases, is related to dyspepsia and ulcerative colitis. An important gene associated with Irritable Bowel Syndrome is MIR510 (microRNA 510), and among its related pathways are SLC-mediated transmembrane transport and Circadian entrainment. The drugs cromolyn sodium and clidinium and the compounds dopamine and norepinephrine have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and cerebellum, and related mouse phenotypes are behavior/neurological and endocrine/exocrine gland.

Disease Ontology:8 A syndrome that is a functional bowel disorder characterized by chronic abdominal pain, discomfort, bloating, and alteration of bowel habits in the absence of any detectable organic cause.

Wikipedia:64 Irritable bowel syndrome (IBS, or spastic colon) is a symptom-based diagnosis characterized by chronic... more...

Aliases & Classifications for Irritable Bowel Syndrome

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 40NCIt, 27ICD9CM, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal


Aliases & Descriptions:

irritable bowel syndrome 8 43 10 34 61
inflammatory bowel diseases 61
irritable colon 8
ibd 8


External Ids:

Disease Ontology8 DOID:9778
NCIt40 C82343
ICD9CM27 564.1
MeSH35 D043183
ICD1025 K58, K58.0, K58.9

Related Diseases for Irritable Bowel Syndrome

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Irritable Bowel Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 333)
idRelated DiseaseScoreTop Affiliating Genes
1dyspepsia31.3HTR3A, CCK, MLNR, MLN
2ulcerative colitis30.9MLN, DEFB4A, F2RL1, AQP8
3gastroesophageal reflux disease30.8MLN, CCK, CCKAR
4panic disorder30.6CCKAR, CCK, HTR3A, SLC6A4
5chronic fatigue syndrome30.6SLC6A4
6anxiety disorder30.6SLC6A4, HTR3A
7generalized anxiety disorder30.5SLC6A4, HTR3A
8bulimia nervosa30.1CCK, SLC6A4
9duodenogastric reflux30.1MLN, CCK
10premature ejaculation30.1SLC6A4
11alzheimer's disease30.1CCK, S100A12, SLC6A4
12cystic fibrosis30.1DEFB4A, CLCN2, F2RL1
13bipolar disorder30.1HTR3A, SLC6A4
14acute pancreatitis30.1CCKAR, CCK, F2RL1
15n syndrome11.0
16serotonin syndrome10.9
17micro syndrome10.9
18inflammatory bowel disease 210.8
19lip disease10.7
20lactose intolerance10.7
21vascular disease10.7
22hepatitis b10.6
23hepatitis d10.6
24inflammatory bowel disease 2010.6
25microscopic colitis10.6
26inflammatory bowel disease 1910.6
27nutrition disease10.6
28inflammatory bowel disease 1010.5
29inflammatory bowel disease 310.5
30venous thrombosis10.5
31tuberculosis10.5
32inflammatory bowel disease 1210.5
33functional diarrhea10.5
34celiac disease10.5
35adult syndrome10.5
36mast syndrome10.5
37chronic pain10.5
38hepatitis c10.5
39ankylosing spondylitis10.5
40arthritis10.5
41spondylitis10.5
42spondyloarthropathy10.5
43inflammatory bowel disease 810.5
44char syndrome10.5
45fibromyalgia10.5
46hepatitis a10.5
47inflammatory bowel disease 710.5
48inflammatory bowel disease 1110.5
49venous thromboembolism10.5
50hyperhomocysteinemia10.4

Graphical network of the top 20 diseases related to Irritable Bowel Syndrome:



Diseases related to irritable bowel syndrome

Clinical Features for Irritable Bowel Syndrome

Drugs & Therapeutics for Irritable Bowel Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Irritable Bowel Syndrome

Drug clinical trials:

Search ClinicalTrials for Irritable Bowel Syndrome

Search NIH Clinical Center for Irritable Bowel Syndrome

Highlights from CenterWatch's Drugs in Clinical Trials Database for Irritable Bowel Syndrome:

idCompanyCompoundMechanismPhase
1Lexicon PharmaceuticalsLX1033An orally-delivered small molecule that inhibits tryptophan hydroxylaseII
2Synergy PharmaceuticalsplecanatideA synthetic analog of uroguanylin a natriuretic hormone that regulates ion and fluid transport in the GI tract.IIb
3Furiex PharmaceuticalsMuDeltaA mu-opioid receptor agonist and delta-opioid receptor antagonistIII
4Salix PharmaceuticalsrifaximinA semisynthetic rifamycin derivative and non-systemic gastrointestinal site-specific broad spectrum antibioticIII
5Tioga PharmaceuticalsasimadolineA peripheral kappa-agonistIII

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Irritable Bowel Syndrome

Anatomical Context for Irritable Bowel Syndrome

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Irritable Bowel Syndrome:

33
Brain, Cortex, Cerebellum, Heart, Small intestine, Colon, Kidney, Liver, Adrenal gland, Breast, Prostate, T cells, Prefrontal cortex, Amygdala, Adrenal cortex, Pituitary

Animal Models for Irritable Bowel Syndrome or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Irritable Bowel Syndrome:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538610.5CCKAR, HTR3A, HTR4, CLCN2, F2RL1, SLC6A4
2MP:000537910.5AQP8, KLB, CCKAR, CCK, HTR3A, CLCN2
3MP:000537610.4KLB, CCKAR, CCK, HTR3A, HTR4, CLCN2
4MP:000363110.2HTR3A, GNB3, CCK, CCKAR, HTR4, CLCN2

Publications for Irritable Bowel Syndrome

Sources:
51PubMed
See all sources

Articles related to Irritable Bowel Syndrome:

(show top 50)    (show all 770)
idTitleAuthorsYear
1
Linaclotide: a review of its use in the treatment of irritable bowel syndrome with constipation. (24293117)
2014
2
Diffusion tensor imaging detects microstructural reorganization in the brain associated with chronic irritable bowel syndrome. (23721972)
2013
3
Linaclotide: a novel compound for the treatment of irritable bowel syndrome with constipation. (24007408)
2013
4
Association between irritable bowel syndrome and colorectal cancer: A nationwide population-based study. (24268837)
2013
5
Effect of cholecystokinin on rectal motor and sensory function in patients with irritable bowel syndrome and healthy controls. (23006632)
2013
6
A long-term profile of patients with irritable bowel syndrome. (23763796)
2013
7
Pharmacologic properties, metabolism, and disposition of linaclotide, a novel therapeutic peptide approved for the treatment of irritable bowel syndrome with constipation and chronic idiopathic constipation. (23090647)
2013
8
Identification of a functional TPH1 polymorphism associated with irritable bowel syndrome bowel habit subtypes. (24060757)
2013
9
Eluxadoline benefits patients with irritable bowel syndrome with diarrhea in a phase 2 study. (23583433)
2013
10
Probiotics VSL#3 protect against development of visceral pain in murine model of irritable bowel syndrome. (23691109)
2013
11
Commentary: irritable bowel syndrome and the CDAI--misleading activity by straw men; authors' reply. (23590539)
2013
12
The epidemiology of irritable bowel syndrome in Denmark. A population-based survey in adults a8o50 years of age. (23506174)
2013
13
Probiotics in the management of irritable bowel syndrome and inflammatory bowel disease. (23286925)
2013
14
Ask the doctor. I have chronic diarrhea because of irritable bowel syndrome (IBS). Should I take probiotics? (23862208)
2013
15
An investigation of fecal volatile organic metabolites in irritable bowel syndrome. (23516449)
2013
16
Are bloating and abdominal distention attributed to gas production and visceral sensitivity in irritable bowel syndrome? (Am j gastroenterol 2013;108:1516-1525). (24199019)
2013
17
Which psychological factors exacerbate irritable bowel syndrome? Development of a comprehensive model. (23731745)
2013
18
Linaclotide for the treatment of irritable bowel syndrome with constipation: is it time to reshuffle the deck? (23791794)
2013
19
Sensory neuro-immune interactions differ between irritable bowel syndrome subtypes. (22767422)
2013
20
Patient satisfaction after gut-directed hypnotherapy in irritable bowel syndrome. (23051178)
2013
21
Management of irritable bowel syndrome with constipation: a flexible approach to treating a complex condition with multiple symptoms. (23859755)
2013
22
Gluten-free diet and irritable bowel syndrome-diarrhea. (23896372)
2013
23
A systematic review of the economic and humanistic burden of illness in irritable bowel syndrome and chronic constipation. (24156644)
2013
24
Targeted therapies for diarrhea-predominant irritable bowel syndrome. (22754282)
2012
25
Irritable bowel syndrome: a holistic approach. (22635277)
2012
26
Quantitative profiling of gut microbiota of children with diarrhea-predominant irritable bowel syndrome. (22986438)
2012
27
Cellular and molecular basis of intestinal barrier dysfunction in the irritable bowel syndrome. (22844557)
2012
28
Imbalanced shift of cytokine expression between T helper 1 and T helper 2 (Th1/Th2) in intestinal mucosa of patients with post-infectious irritable bowel syndrome. (22816602)
2012
29
Effect of a glucagon-like peptide 1 analog, ROSE-010, on GI motor functions in female patients with constipation-predominant irritable bowel syndrome. (22517769)
2012
30
Pro-inflammatory and anti-inflammatory cytokine response in diarrhoea-predominant irritable bowel syndrome patients. (23923350)
2012
31
Rome III survey of irritable bowel syndrome among ethnic Malays. (23197894)
2012
32
Clinical trial: Lactobacillus plantarum 299v (DSM 9843) improves symptoms of irritable bowel syndrome. (22912552)
2012
33
Pro-inflammatory chemokine C-C motif ligand 16 (CCL-16) dysregulation in irritable bowel syndrome (IBS): a pilot study. (21951809)
2011
34
Influence of irritable bowel syndrome on treatment outcome in gastroesophageal reflux disease. (21912473)
2011
35
Irritable bowel syndrome associated with mitral valve prolapse and autonomic and haemostatic abnormalities in children, adolescents and adults with migraine. (21426307)
2011
36
Relative importance of abnormalities of CCK and 5-HT (serotonin) in Giardia-induced post-infectious irritable bowel syndrome and functional dyspepsia. (20132151)
2010
37
Phenotypic analysis of Th cells in colon and peripheral blood in patients with irritable bowel syndrome]. (20058616)
2009
38
Genetic determination of irritable bowel syndrome. (19034965)
2008
39
Correlation of gut hormones with irritable bowel syndrome. (18948690)
2008
40
Serotonin receptor modulators in the treatment of irritable bowel syndrome. (18728719)
2008
41
Expression of human beta-defensin 2 and tumor necrosis factor-A in colonic mucosae of ulcerative colitis and diarrhea-predominant irritable bowel syndrome]. (18756966)
2008
42
Faecal S100A12 as a non-invasive marker distinguishing inflammatory bowel disease from irritable bowel syndrome. (17675327)
2007
43
Hypothalamic-pituitary-gut axis dysregulation in irritable bowel syndrome: plasma cytokines as a potential biomarker? (16472586)
2006
44
Are cardiac syndrome X, irritable bowel syndrome and reflex sympathetic dystrophy examples of lateral medullary ischaemic syndromes? (15893131)
2005
45
Diagnostic and therapeutic strategies in the irritable bowel syndrome. (15467518)
2004
46
Irritable bowel syndrome genophenomics: correlation of serotonin-transporter polymorphisms and alosetron response. (12746730)
2003
47
Tegaserod maleate in the treatment of irritable bowel syndrome: a clinical review. (12946544)
2003
48
New drugs in the management of the irritable bowel syndrome. (9664195)
1998
49
Oxytocin increases thresholds of colonic visceral perception in patients with irritable bowel syndrome. (9014776)
1996
50
Effect of a 5HT3-antagonist (ondansetron) on rectal sensitivity and compliance in health and the irritable bowel syndrome. (8280823)
1993

Genetic Variations for Irritable Bowel Syndrome

Expression for genes affiliated with Irritable Bowel Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Irritable Bowel Syndrome

Search GEO for disease gene expression data for Irritable Bowel Syndrome.

Pathways for genes affiliated with Irritable Bowel Syndrome

Sources:
54Reactome, 30KEGG, 38NCBI BioSystems Database, 50PharmGKB, 12EMD Millipore
See all sources

Pathways related to Irritable Bowel Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.5GNB3, HTR3A, HTR3E, CLCN2, AQP8
2
Hide members
10.5SLC6A4, HTR3E, HTR4, HTR3A, GNB3
3
Hide members
10.5KLB, CCL16, CCKAR, CCK, GNB3, HTR4
4
Hide members
10.5HTR3A, HTR4, SLC6A4, ADRA2A
5
Hide members
10.5CCKAR, CCK, GNB3, MLNR, MLN, F2RL1
6
Hide members
10.5ADRA2C, ADRA2A, GNB3
7
Hide members
10.5ADRA2A, CCL16, CCKAR, CCK, GNB3, HTR4
8
Hide members
10.5AQP8, ADRA2C, ADRA2A, GNB3
9
Hide members
10.5ADRA2A, ADRA2C

Compounds for genes affiliated with Irritable Bowel Syndrome

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 2BitterDB, 60Tocris Bioscience
See all sources

Compounds related to Irritable Bowel Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 123)
idCompoundScoreTop Affiliating Genes
1dopamine45 29 11 2414.0ADRA2C, CCKAR, CCK, GNB3, HTR3A, MLNR
2norepinephrine45 11 2413.0CCK, GNB3, HTR3A, F2RL1, SLC6A4, ADRA2A
3clozapine45 29 50 1114.0GNB3, HTR3A, F2RL1, SLC6A4, ADRA2A, ADRA2C
4dexloxiglumide45 2911.9MLN, HTR3A, CCK, CCKAR
5tegaserod45 29 1112.9CCK, HTR3A, HTR4, MLN, SLC6A4
6benzodiazepines4510.9CCKAR, CCK, HTR3A, F2RL1
7ondansetron45 50 11 2413.9CCKAR, CCK, HTR3A, HTR4, MLN
85-hydroxytryptamine4510.9CCK, HTR3A, HTR4, MLN, F2RL1, SLC6A4
9cisapride45 29 1112.9CCK, HTR3A, HTR4, MLNR, MLN
10mianserin29 45 1112.9ADRA2A, SLC6A4, HTR4, HTR3A
11metoclopramide45 1111.9CCK, HTR3A, HTR4, MLN
12yohimbine45 29 2 1113.9HTR3A, HTR4, ADRA2A, ADRA2C
13omeprazole45 29 50 11 2414.9CCKAR, CCK, MLN, CLCN2
14alosetron45 1111.9SLC6A4, HTR3A, CCK
15risperidone29 45 50 60 11 2415.9HTR3A, SLC6A4, ADRA2A, ADRA2C
16caerulein4510.9CCKAR, CCK, MLN
17prucalopride45 2911.9MLN, HTR4, HTR3A
18clonidine45 29 1112.9GNB3, SLC6A4, ADRA2A, ADRA2C
19olanzapine50 45 29 11 2414.9GNB3, HTR3A, ADRA2A, ADRA2C
20granisetron45 1111.9HTR4, HTR3A, CCK
21Ephedra1110.9ADRA2C, ADRA2A, SLC6A4
22tetrodotoxin45 60 2912.9CCKAR, CCK, HTR3A, MLN
23octreotide45 60 29 1113.9CCKAR, CCK, MLN, F2RL1
24gaba4510.9CCKAR, CCK, HTR3A, F2RL1, SLC6A4
25nefazodone45 50 1112.9ADRA2A, SLC6A4, HTR3A
26atropine45 29 1112.9CCKAR, CCK, HTR4, MLN
27mirtazapine50 45 1112.9HTR3A, SLC6A4, ADRA2A
28fenfluramine29 45 1112.9SLC6A4, HTR3A, CCK
29benzodiazepine4510.8HTR3A, CCK, CCKAR
30ketanserin29 4511.8HTR3A, HTR4, SLC6A4
31doxepin45 29 50 1113.8SLC6A4, ADRA2A, ADRA2C
32gr 11380845 60 2912.8HTR4, HTR3A
33mosapride45 2911.8HTR4, HTR3A
34indole4510.8HTR3A, HTR4, SLC6A4
35ranitidine45 29 11 2413.8CCK, MLN, F2RL1
36sumatriptan45 29 60 50 11 2415.8GNB3, HTR3A, MLN
37prazosin45 29 50 1113.8HTR4, ADRA2A, ADRA2C
38aripiprazole29 50 45 11 2414.8HTR3A, ADRA2A, ADRA2C
39histamine45 29 2412.7F2RL1, DEFB4A, MLN, HTR3A, CCK
40acetylcholine45 50 29 11 2414.7CCK, HTR3A, HTR4, MLN, F2RL1
41ziprasidone50 29 45 1113.7ADRA2C, ADRA2A, HTR3A
421,4-benzodiazepine4510.7CCK, CCKAR
43asperlicin4510.7CCK, CCKAR
44em 5234510.6MLN, MLNR
45zacopride45 2911.6HTR4, HTR3A
46arc-2392910.6ADRA2A, ADRA2C
47rx8210022910.5ADRA2A, ADRA2C
48dexmedetomidine hydrochloride6010.5ADRA2A, ADRA2C
49[3h]rx8210022910.4ADRA2A, ADRA2C
50atipamezole hydrochloride6010.2ADRA2A, ADRA2C

GO Terms for genes affiliated with Irritable Bowel Syndrome

Sources:
16Gene Ontology
See all sources

Cellular components related to Irritable Bowel Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:00588710.5HTR3A, HTR4, MLNR, F2RL1, SLC6A4, ADRA2A
2plasma membraneGO:00588610.2LY96, KLB, CCKAR, S100A12, GNB3, HTR3A

Biological processes related to Irritable Bowel Syndrome according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1G-protein coupled receptor signaling pathwayGO:00718610.8ADRA2C, GNB3, HTR4, MLNR, MLN, DEFB4A
2negative regulation of uterine smooth muscle contractionGO:07047310.8ADRA2C, ADRA2A
3activation of MAPK activity by adrenergic receptor signaling pathwayGO:07188310.7ADRA2A, ADRA2C
4epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathwayGO:03562510.7ADRA2C, ADRA2A
5digestionGO:00758610.7CCKAR, HTR3A, MLNR
6negative regulation of epinephrine secretionGO:03281110.7ADRA2C, ADRA2A
7negative regulation of norepinephrine secretionGO:01070010.7ADRA2C, ADRA2A
8serotonin receptor signaling pathwayGO:00721010.6HTR3A, HTR4
9inflammatory responseGO:00695410.6LY96, F2RL1, S100A12, CCL16
10energy reserve metabolic processGO:00611210.6GNB3, ADRA2A, ADRA2C
11regulation of sensory perception of painGO:05193010.5ADRA2C, CCK
12innate immune responseGO:04508710.5KLB, S100A12, DEFB4A, F2RL1, LY96
13activation of protein kinase B activityGO:03214810.4ADRA2C, ADRA2A
14ion transmembrane transportGO:03422010.2CLCN2, HTR3E, HTR3A

Molecular functions related to Irritable Bowel Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1epinephrine bindingGO:05137910.5ADRA2C, ADRA2A
2alpha2-adrenergic receptor activityGO:00493810.2ADRA2C, ADRA2A

Products for genes affiliated with Irritable Bowel Syndrome

  • Antibodies
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Sources for Irritable Bowel Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet