IBD
MCID: IRR002
MIFTS: 58

Irritable Bowel Syndrome (IBD) malady

Categories: Gastrointestinal diseases, Blood diseases

Aliases & Classifications for Irritable Bowel Syndrome

Aliases & Descriptions for Irritable Bowel Syndrome:

Name: Irritable Bowel Syndrome 12 41 42 14 69
Ibd 12 3
Irritable Colon 12
Psychogenic Ibs 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9778
ICD10 33 K58 K58.9 K58.0
ICD9CM 35 564.1
MeSH 42 D043183
NCIt 47 C82343
UMLS 69 C0022104

Summaries for Irritable Bowel Syndrome

MedlinePlus : 41 irritable bowel syndrome (ibs) is a problem that affects the large intestine. it can cause abdominal cramping, bloating, and a change in bowel habits. some people with the disorder have constipation. some have diarrhea. others go back and forth between the two. although ibs can cause a great deal of discomfort, it does not harm the intestines. ibs is common. it affects about twice as many women as men and is most often found in people younger than 45 years. no one knows the exact cause of ibs. there is no specific test for it. your doctor may run tests to be sure you don't have other diseases. these tests may include stool sampling tests, blood tests, and x-rays. your doctor may also do a test called a sigmoidoscopy or colonoscopy. most people diagnosed with ibs can control their symptoms with diet, stress management, probiotics, and medicine. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary : Irritable Bowel Syndrome, also known as ibd, is related to isobutyryl-coa dehydrogenase deficiency and gastrointestinal defects and immunodeficiency syndrome, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Irritable Bowel Syndrome is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1), and among its related pathways/superpathways are Inflammatory bowel disease (IBD) and Peptide ligand-binding receptors. The drugs Loperamide and Pentoxifylline have been mentioned in the context of this disorder. Affiliated tissues include colon, testes and kidney, and related phenotypes are Decreased viability and behavior/neurological

Disease Ontology : 12 A syndrome that is a functional bowel disorder characterized by chronic abdominal pain, discomfort, bloating, and alteration of bowel habits in the absence of any detectable organic cause.

Wikipedia : 71 Irritable bowel syndrome (IBS) is a group of symptoms—including abdominal pain and changes in the... more...

Related Diseases for Irritable Bowel Syndrome

Diseases related to Irritable Bowel Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 152)
id Related Disease Score Top Affiliating Genes
1 isobutyryl-coa dehydrogenase deficiency 11.6
2 gastrointestinal defects and immunodeficiency syndrome 11.4
3 diarrhea 11.3
4 fecal incontinence 11.2
5 interstitial cystitis 11.1
6 acquired fructose intolerance 10.8
7 hereditary alpha tryptasemia syndrome 10.8
8 colonic disease 10.8
9 constipation 10.6
10 dyspepsia 10.5
11 inflammatory bowel disease 10.4
12 colitis 10.4
13 pyridoxal 5'-phosphate-dependent epilepsy 10.3 IL10 TNF
14 mucositis 10.3
15 tubular renal disease-cardiomyopathy syndrome 10.3 IL10 TNF
16 ornithosis 10.3 CCK HTR3A SLC6A4
17 lactose intolerance 10.3
18 cytomegalic congenital adrenal hypoplasia 10.2 HTR3A SLC6A4 TNF
19 ischemic neuropathy 10.2 CCK HTR3A MLN
20 microscopic colitis 10.2
21 chagas disease 10.2 CCK HTR3A SLC6A4
22 gastroesophageal reflux 10.2
23 cerebral convexity meningioma 10.2 IL10 SLC6A4 TPH1
24 lagophthalmos 10.2 IL10 TNF
25 primary pigmented nodular adrenocortical disease 10.2 CCK CCKAR IL10
26 lichen disease 10.2 CRH IL10 SLC6A4 TNF
27 celiac disease 10.1
28 hematocele of tunica vaginalis testis 10.1 HTR7 SLC6A4 TNF
29 conjunctival pigmentation 10.1 CRH HTR7 SLC6A4
30 childhood intracortical osteosarcoma 10.1 CCK HTR4 MLN TRPV1
31 postencephalitic parkinson disease 10.1 CRHR1 HTR3A SLC6A4 TPH1
32 hidrocystoma 10.1 HTR4 HTR7 MLN
33 ulcerative colitis 10.1
34 gastroenteritis 10.1
35 placental insufficiency 10.1 HTR4 HTR7 MLN
36 hereditary multiple exostoses 10.1 CRH CRHR1 SLC6A4
37 hypoglycemic coma 10.1 CRH CRHR1 SLC6A4 TPH1
38 tularemia 10.1 IL10 TLR9 TNF
39 tuberculosis 10.1 IL10 TLR9 TNF
40 renpenning syndrome 10.1 HTR3A HTR7 SLC6A4 TPH1
41 motor peripheral neuropathy 10.1 IL10 TLR9 TNF
42 mansonelliasis 10.1 IL10 TLR9 TNF
43 unilateral hypoactive labyrinth 10.0 IL10 TLR9 TNF
44 lacrimal system cancer 10.0 CCK CCKAR IL10
45 functional diarrhea 10.0
46 restless legs syndrome 10.0
47 liver inflammatory pseudotumor 10.0 IL10 TLR9 TNF
48 keratosis 10.0 CRH HTR7 SLC6A4 TPH1
49 atrial fibrillation, familial, 10 10.0 CHGA HTR3A IL10 SLC6A4 TPH1
50 alzheimer disease 17 10.0 CRH HTR7 SLC6A4 TPH1

Comorbidity relations with Irritable Bowel Syndrome via Phenotypic Disease Network (PDN): (show all 25)


Active Peptic Ulcer Disease Acute Cystitis
Acute Pancreatitis Anxiety Disorder
Atrophic Gastritis Bronchitis
Chronic Myocardial Ischemia Deficiency Anemia
Dependent Personality Disorder Dyskinesia of Esophagus
Dysthymic Disorder Esophagitis
Generalized Anxiety Disorder Hypertension, Essential
Hypochondriasis Hypothyroidism
Intermediate Coronary Syndrome Intestinal Obstruction
Iron Deficiency Anemia Ischemic Heart Disease
Mitral Valve Disease Osteoporosis
Paralytic Ileus Protein-Energy Malnutrition
Somatization Disorder

Graphical network of the top 20 diseases related to Irritable Bowel Syndrome:



Diseases related to Irritable Bowel Syndrome

Symptoms & Phenotypes for Irritable Bowel Syndrome

UMLS symptoms related to Irritable Bowel Syndrome:


abdominal pain, constipation, diarrhea, dyspepsia, heartburn, icterus, nausea and vomiting, vomiting following gastrointestinal surgery, gastrointestinal gas

GenomeRNAi Phenotypes related to Irritable Bowel Syndrome according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00381-A-1 9.1 HTR3A MLN SLC6A4
2 Decreased viability GR00381-A-3 9.1 HTR3A MLN SLC6A4

MGI Mouse Phenotypes related to Irritable Bowel Syndrome:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.3 CCK CCKAR CRH CRHR1 HTR3A HTR4
2 homeostasis/metabolism MP:0005376 10.2 TPH1 TRPV1 CCK CCKAR CHGA CRH
3 growth/size/body region MP:0005378 10.11 CCKAR CHGA CRH HTR3A HTR4 IL10
4 endocrine/exocrine gland MP:0005379 10.1 CCK CCKAR CHGA CRH CRHR1 HTR3A
5 cardiovascular system MP:0005385 10.09 TPH1 TRPV1 CHGA CRHR1 IL10 SLC6A4
6 nervous system MP:0003631 9.97 CCK CCKAR CRH CRHR1 GNB3 HTR3A
7 integument MP:0010771 9.91 CRH HTR3A HTR7 IL10 SLC6A4 TAC1
8 no phenotypic analysis MP:0003012 9.5 CCK CRH CRHR1 IL10 TGM2 TNF
9 renal/urinary system MP:0005367 9.23 HTR3A CCKAR CHGA CRH TAC1 TGM2

Drugs & Therapeutics for Irritable Bowel Syndrome

Drugs for Irritable Bowel Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 334)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Loperamide Approved Phase 4,Phase 3,Phase 2 53179-11-6 3955
2
Pentoxifylline Approved, Investigational Phase 4 6493-05-6 4740
3
Citalopram Approved Phase 4,Phase 2 59729-33-8 2771
4
Esomeprazole Approved, Investigational Phase 4 161796-78-7, 119141-88-7 4594 9579578
5 Ramosetron Approved Phase 4,Phase 3,Phase 2 132036-88-5
6
Norepinephrine Approved Phase 4 51-41-2 439260
7
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
8
Pantoprazole Approved Phase 4 102625-70-7 4679
9
Histamine Approved, Investigational Phase 4,Phase 2 75614-87-8, 51-45-6 774
10
Hydrocortisone Approved, Vet_approved Phase 4,Phase 2 50-23-7 5754 657311
11
Ondansetron Approved Phase 4,Phase 2 99614-02-5 4595
12
Metronidazole Approved Phase 4 443-48-1 4173
13
Lubiprostone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 136790-76-6 656719
14
Paroxetine Approved, Investigational Phase 4 61869-08-7 43815
15 Trimebutine Approved Phase 4 39133-31-8
16
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 2 148553-50-8 5486971
17
Nitazoxanide Approved, Investigational, Vet_approved Phase 4 55981-09-4 41684
18
Pancrelipase Approved Phase 4 53608-75-6
19
Alverine Approved Phase 4 150-59-4 3678
20 Simethicone Approved Phase 4,Phase 1
21
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
22
Eluxadoline Approved Phase 4 864821-90-9
23
Amitriptyline Approved Phase 4 50-48-6 2160
24
Perphenazine Approved Phase 4 58-39-9 4748
25
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
26
Cholecalciferol Approved, Nutraceutical Phase 4,Phase 1 67-97-0 6221 10883523 5280795
27
Genistein Investigational Phase 4 446-72-0 5280961
28
Maleic acid Experimental Phase 4 110-16-7 444266
29 mosapride Phase 4,Phase 3,Phase 2 112885-41-3
30 Mesalamine Phase 4,Phase 2,Phase 3 89-57-6
31
Proton pump inhibitors Phase 4
32 calcium channel blockers Phase 4,Phase 2
33
Serotonin Phase 4,Phase 3,Phase 2,Early Phase 1 50-67-9 5202
34 Muscarinic Antagonists Phase 4,Phase 2
35 Cholinergic Agents Phase 4,Phase 2
36 Cholinergic Antagonists Phase 4,Phase 2
37 Serotonin Agents Phase 4,Phase 3,Phase 2
38 Adrenergic Agents Phase 4,Phase 3,Phase 2,Phase 1
39 Serotonin Antagonists Phase 4,Phase 3,Phase 2
40 Serotonin Uptake Inhibitors Phase 4,Phase 2
41 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1
42 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1
43 Sulfalene Phase 4,Phase 2,Phase 3,Phase 1
44 Neurotransmitter Uptake Inhibitors Phase 4,Phase 3,Phase 2
45 Tiropramide Phase 4 55837-29-1 42262
46 Dermatologic Agents Phase 4,Phase 2,Phase 3,Phase 1
47 Octylonium Phase 4
48 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
49 Hormones Phase 4,Phase 2,Phase 3,Phase 1
50 Parasympatholytics Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 618)
id Name Status NCT ID Phase
1 Saccharomyces Boulardii in Diarrhea Dominant Irritable Bowel Syndrome Unknown status NCT00543478 Phase 4
2 Comparison of the Efficacy and Safety of Tiropramide and Octylonium in the Treatment of Irritable Bowel Syndrome Unknown status NCT01629212 Phase 4
3 Effect of Pentoxifylline on Tight Junctions (TJs) of Intestinal Mucosa in Patients With Irritable Bowel Syndrome(IBS) Unknown status NCT01542268 Phase 4
4 Manipulation of Visceral Sensitivity and Immune System in IBS Unknown status NCT00418340 Phase 4
5 Effect of Mosapride on Gut Transit in Patients With Chronic Constipation or Constipated Irritable Bowel Syndrome and Healthy Subjects Unknown status NCT02433847 Phase 4
6 The Efficacy of Hydrolyzed Guar Gum ( PHGG) in the Treatment of Patients With Irritable Bowel Syndrome (IBS) Unknown status NCT01779765 Phase 4
7 Changes in Gastrointestinal Microbiota Using VSL#3 in Patients With IBS-D Unknown status NCT01638208 Phase 4
8 Safety and Therapeutic Efficacy of Phosphate Enema (Kleen Enema) in Patients Undergoing Sigmoidoscopy Unknown status NCT02386904 Phase 4
9 Probiotic in Irritable Bowel Syndrome (IBS) Patients With Diarrhea Unknown status NCT01667627 Phase 4
10 Effect of Ramosetron on Bowel Motility After Colorectal Resection Unknown status NCT01427127 Phase 4
11 Gastric Functions & Proton Pump Inhibitor( PPI) Study Unknown status NCT00951431 Phase 4
12 Curcumin (Tumeric) in the Treatment of Irritable Bowel Syndrome: A Randomized-Controlled Trial Completed NCT00779493 Phase 4
13 An Open-Label Trial of Duloxetine for the Treatment of Irritable Bowel Syndrome Completed NCT00401258 Phase 4
14 Paroxetine - Controlled Release in the Treatment of Irritable Bowel Syndrome (IBS) Completed NCT00610909 Phase 4
15 Management of Irritable Bowel Syndrome in Primary Care (MIBS Trial) Completed NCT00934973 Phase 4
16 An Open Label Trial of Duloxetine in the Treatment of Irritable Bowel Syndrome and Comorbid Generalized Anxiety Disorder Completed NCT00961298 Phase 4
17 Open Trial of Duloxetine in Outpatients With Irritable Bowel Syndrome Symptoms and Co-Morbid Major Depression Completed NCT01754493 Phase 4
18 Manipulation of Visceral Hypersensitivity With Probiotic Bacteria in Irritable Bowel Syndrome Completed NCT01139736 Phase 4
19 Pregabalin on Colonic Motor and Sensory Function in Constipation Predominant Irritable Bowel Syndrome Completed NCT01331213 Phase 4
20 Effectiveness of On-demand Meteospasmyl® Use in Irritable Bowel Syndrome (IBS) Completed NCT01404923 Phase 4
21 Validation of Surrogate Measures in Irritable Bowel Syndrome (IBS) Completed NCT00693732 Phase 4
22 A Study to Evaluate Efficacy of Ramosetron on Diarrhea-predominant Irritable Bowel Syndrome (IBS) in Male Patients Completed NCT01225237 Phase 4
23 A Preliminary Study to Explore Clinical Endpoints in Patients (Male) With Diarrhea-predominant Irritable Bowel Syndrome Completed NCT00918411 Phase 4
24 Escitalopram Trial for Irritable Bowel Syndrome (IBS) Patients With Panic Disorder Completed NCT01551225 Phase 4
25 Mesalazine for the Treatment of Diarrhoea-predominant Irritable Bowel Syndrome (IBS-D) Completed NCT01316718 Phase 4
26 Irritable Bowel Syndrome Evaluation and Treatment in Primary Care Completed NCT01641341 Phase 4
27 Efficacy Evaluation of a Commercial Preparation Containing Lactobacillus Casei DG on the Reduction of the Painful Symptoms Related to the Irritable Bowel Syndrome (IBS). A Pilot Clinical Study Completed NCT02077699 Phase 4
28 Effect of Lactobacillus Plantarum 299v on Symptoms of Irritable Bowel Syndrome Completed NCT01886781 Phase 4
29 Efficacy and Safety of Meteospasmyl® in Irritable Bowel Syndrome Completed NCT00542295 Phase 4
30 Irritable Bowel Syndrome (IBS) Treatment With H1-receptor Antagonists Completed NCT01144832 Phase 4
31 Ability of Mayo Clinic High-performance Liquid Chromatography (HPLC) Method to Measure Fecal Bile Acids Completed NCT02111603 Phase 4
32 Comparative Efficacy and Safety of Fenoverine Completed NCT01507922 Phase 4
33 Efficacy of Tegaserod in Relieving the Symptoms of Female Patients With Irritable Bowel Syndrome (IBS), Excluding Those With Predominant Diarrhea IBS Completed NCT00142987 Phase 4
34 Effect of Cholecalciferol, Soy Isoflavones in Patients With Irritable Bowel Syndrome Completed NCT02026518 Phase 4
35 EFESO - EFficacy Enterogermina Small Intestinal Bacterial Overgrowth Completed NCT00331994 Phase 4
36 Ondansetron for the Treatment of IBS With Diarrhoea (IBS-D) Completed NCT00745004 Phase 4
37 Study to Assess the Effect Of Alosetron On Mucosal Blood Flow Completed NCT00370032 Phase 4
38 Bifidobacteria In Children With Abdominal Pain-Associated Functional Gastrointestinal Disorders Completed NCT02566876 Phase 4
39 Mode of Action of Moviprep Completed NCT01622972 Phase 4
40 Lubiprostone in Patients With Multiple Sclerosis Associated Constipation Completed NCT01236534 Phase 4
41 Imaging the Effect of Experimental Stress on Small and Large Bowel Water During Fructose Absorption Completed NCT01763281 Phase 4
42 The Effect of Corticotrophin-releasing Hormone (CRH) on Esophageal Motility in Healthy Volunteers Completed NCT02736734 Phase 4
43 Single-dose Linaclotide for Capsule Endoscopy Preparation Completed NCT02465385 Phase 4
44 Glucomannan for the Treatment of Abdominal Pain-related Functional Gastrointestinal Disorders in Childhood Completed NCT01495806 Phase 4
45 Efficacy and Tolerability of α-galactosidase in Treating Gas-related Symptoms in Children Completed NCT01595932 Phase 4
46 Effect of Clostridium Butyricum in Treating Irritable Bowel Syndrome Recruiting NCT02614963 Phase 4
47 Lactibiane Tolérance® in Individuals Suffering From Irritable Bowel Syndrome With Diarrheal Predominance Recruiting NCT02728063 Phase 4
48 Efficacy of Eluxadoline in the Treatment of Irritable Bowel Syndrome With Diarrhea in Patients With Inadequate Control of Symptoms With Prior Loperamide Use Recruiting NCT02959983 Phase 4
49 Pain Relief In Irritable Bowel Syndrome Recruiting NCT02573844 Phase 4
50 Is Microbiota Community Associated With Clinical Response to a Low FODMAP Diet in Patients With Irritable Bowel Syndrome Recruiting NCT02565550 Phase 4

Search NIH Clinical Center for Irritable Bowel Syndrome

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: irritable bowel syndrome

Genetic Tests for Irritable Bowel Syndrome

Anatomical Context for Irritable Bowel Syndrome

MalaCards organs/tissues related to Irritable Bowel Syndrome:

39
Colon, Testes, Kidney, Brain, Small Intestine, Prostate, Pituitary

Publications for Irritable Bowel Syndrome

Articles related to Irritable Bowel Syndrome:

(show top 50) (show all 948)
id Title Authors Year
1
Optimizing the Use of Linaclotide in Patients with Constipation-Predominant Irritable Bowel Syndrome: An Expert Consensus Report. ( 28083815 )
2017
2
Editorial: volatile organic compounds in irritable bowel syndrome - technology for an accurate and reliable point-of-care test? ( 28074509 )
2017
3
The Place of Stress and Emotions in the Irritable Bowel Syndrome. ( 28061975 )
2017
4
Is-it possible to distinguish irritable bowel syndrome with constipation from functional constipation? ( 28066860 )
2017
5
Irritable Bowel Syndrome-Like Symptoms Following Fecal Microbiota Transplantation: A Possible Donor-Dependent Complication. ( 28050036 )
2017
6
Self-rated health and functional capacity in individuals reporting overlapping symptoms of gastroesophageal reflux disease, functional dyspepsia and irritable bowel syndrome - a population based study. ( 28521729 )
2017
7
Microscopic colitis: a missed diagnosis among patients with moderate to severe irritable bowel syndrome. ( 27796144 )
2017
8
Aminophylline suppresses stress-induced visceral hypersensitivity and defecation in irritable bowel syndrome. ( 28054654 )
2017
9
Editorial: increased expression of nerve growth factor correlates with visceral hypersensitivity and impaired gut barrier function in diarrhoea-predominant irritable bowel syndrome. Authors' reply. ( 28074518 )
2017
10
Prevalence and Impact of Inflammatory Bowel Disease-Irritable Bowel Syndrome on Patient-reported Outcomes in CCFA Partners. ( 28092305 )
2017
11
Damage of the Mucus Layer: The Possible Shared Critical Common Cause for Both Inflammatory Bowel Disease (IBD) and Irritable Bowel Syndrome (IBS). ( 28079624 )
2017
12
Prevalence, Risk Factors, and Outcomes of Irritable Bowel Syndrome After Infectious Enteritis: a Systematic Review and Meta-analysis. ( 28069350 )
2017
13
Editorial: increased expression of nerve growth factor correlates with visceral hypersensitivity and impaired gut barrier function in diarrhoea-predominant irritable bowel syndrome. ( 28074514 )
2017
14
Increased Expression of Toll-Like Receptors 4, 5, and 9 in Small Bowel Mucosa from Patients with Irritable Bowel Syndrome. ( 28246611 )
2017
15
Blastocystis and irritable bowel syndrome: Frequency and subtypes from Iranian patients. ( 28087441 )
2017
16
Structural and functional alterations in the colonic microbiome of the rat in a model of stress induced irritable bowel syndrome. ( 28059627 )
2017
17
Economic burden of irritable bowel syndrome in China. ( 28058026 )
2016
18
Visceral hypersensitivity in inflammatory bowel diseases and irritable bowel syndrome: The role of proteases. ( 28058009 )
2016
19
Validation of an LC-MS/MS Method for Urinary Lactulose and Mannitol Quantification: Results in Patients with Irritable Bowel Syndrome. ( 28070137 )
2016
20
Prevalence of Irritable Bowel Syndrome (IBS), Migraine and Co-Existing IBS-Migraine in Medical Students. ( 28050419 )
2016
21
The Severity of Symptoms Related to Irritable Bowel Syndrome is a Risk Factor for the Misclassification of Significant Organic Disease. ( 27661976 )
2016
22
Evidence that independent gut-to-brain and brain-to-gut pathways operate in the irritable bowel syndrome and functional dyspepsia: a 1-year population-based prospective study. ( 27444264 )
2016
23
Managing irritable bowel syndrome: The low-FODMAP diet. ( 27618353 )
2016
24
Restriction of FODMAP in the management of bloating in irritable bowel syndrome. ( 27664186 )
2016
25
The feasibility, usability, and clinical utility of traditional paper food and symptom journals for patients with irritable bowel syndrome. ( 27619957 )
2016
26
Negative Effects on Psychological Health and Quality of Life of Genuine Irritable Bowel Syndrome-type Symptoms in Patients With Inflammatory Bowel Disease. ( 27189912 )
2016
27
Activation of 5-HT and NR2B contributes to visceral hypersensitivity in irritable bowel syndrome in rats. ( 28078028 )
2016
28
Irritable Bowel Syndrome: A Global Challenge Among Medical Students. ( 27625907 )
2016
29
Irritable bowel syndrome symptom severity improves equally with probiotic and placebo. ( 28082816 )
2016
30
Childhood Irritable Bowel Syndrome Characteristics Are Related to Both Sex and Pubertal Development. ( 27639531 )
2016
31
Editorial: gut-directed hypnotherapy or low FODMAP diet for the treatment of irritable bowel syndrome? ( 27634230 )
2016
32
Drugs for irritable bowel syndrome. ( 27649342 )
2016
33
Histamine Receptor H1-Mediated Sensitization of TRPV1 Mediates Visceral Hypersensitivity and Symptoms in Patients With Irritable Bowel Syndrome. ( 26752109 )
2016
34
Extra-intestinal symptoms in patients with irritable bowel syndrome: related to high total IgE levels and atopic sensitization? ( 27161383 )
2016
35
Prevalence of irritable bowel syndrome - like symptoms in Japanese patients with inactive inflammatory bowel disease. ( 27193973 )
2016
36
Limited prolonged effects of rifaximin treatment on irritable bowel syndrome-related differences in the fecal microbiome and metabolome. ( 27662586 )
2016
37
Efficacy of double-coated probiotics for irritable bowel syndrome: a randomized double-blind controlled trial. ( 27178566 )
2016
38
Irritable bowel syndrome. ( 27191484 )
2016
39
Response of irritable bowel syndrome with constipation patients administered a combined quebracho/conker tree/M. balsamea Willd extract. ( 27602249 )
2016
40
Mind-Body Interventions for Irritable Bowel Syndrome Patients in the Chinese Population: a Systematic Review and Meta-Analysis. ( 27646279 )
2016
41
Severe Asthma with Joint Pain, Thrombophilia, and Irritable Bowel Syndrome. ( 27587324 )
2016
42
Irritable bowel syndrome: 4 big questions. ( 27191493 )
2016
43
Does frequency of restless legs syndrome and poor sleep quality increase with age in irritable bowel syndrome? ( 27624325 )
2016
44
Patients' experiences of health care encounters in severe irritable bowel syndrome: an analysis based on narrative and feminist theory. ( 27218818 )
2016
45
Associations between Single-Nucleotide Polymorphisms in Corticotropin-Releasing Hormone-Related Genes and Irritable Bowel Syndrome. ( 26882083 )
2016
46
Corticotropin-Releasing Hormone Receptor 2 Gene Variants in Irritable Bowel Syndrome. ( 26808377 )
2016
47
Irritable Bowel Syndrome May Be Associated with Elevated Alanine Aminotransferase and Metabolic Syndrome. ( 26632395 )
2016
48
Treatment of irritable bowel syndrome with a novel colonic irrigation system: a pilot study. ( 27194235 )
2016
49
Chemical and Molecular Factors in Irritable Bowel Syndrome: Current Knowledge, Challenges and Unanswered Questions. ( 27609770 )
2016
50
Biomarkers to distinguish functional constipation from irritable bowel syndrome with constipation. ( 27214096 )
2016

Variations for Irritable Bowel Syndrome

Expression for Irritable Bowel Syndrome

Search GEO for disease gene expression data for Irritable Bowel Syndrome.

Pathways for Irritable Bowel Syndrome

Pathways related to Irritable Bowel Syndrome according to KEGG:

37
id Name Kegg Source Accession
1 Inflammatory bowel disease (IBD) hsa05321

Pathways related to Irritable Bowel Syndrome according to GeneCards Suite gene sharing:

(show all 14)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.29 CCK CCKAR CRH CRHR1 GNB3 HTR4
2
Show member pathways
13.12 GNB3 HTR3A HTR3E HTR4 HTR7 TGM2
4 11.91 GNB3 HTR3A IL10 SLC6A4 TAC1 TNF
5 11.82 CRH CRHR1 GNB3 HTR4 HTR7
6
Show member pathways
11.74 IL10 TLR9 TNF
7 11.67 CRH CRHR1 GNB3
8 11.57 IL10 TLR9 TNF
9 11.5 IL10 TLR9 TNF
10 11.27 IL10 TLR9 TNF
11 11.22 GNB3 HTR3A HTR3E HTR4 HTR7 SLC6A4
12 11.09 IL10 TLR9 TNF
13 10.8 HTR3A HTR4 HTR7 SLC6A4 TPH1
14 10.28 CRH CRHR1

GO Terms for Irritable Bowel Syndrome

Cellular components related to Irritable Bowel Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.8 CCKAR CRHR1 HTR4 HTR7 SLC6A4 TNF
2 plasma membrane GO:0005886 9.77 CCKAR CRHR1 GNB3 HTR3A HTR3E HTR4
3 neuronal cell body GO:0043025 9.55 CCK CRH HTR3A TAC1 TRPV1
4 intrinsic component of plasma membrane GO:0031226 8.8 CRHR1 TGM2 TRPV1

Biological processes related to Irritable Bowel Syndrome according to GeneCards Suite gene sharing:

(show all 20)
id Name GO ID Score Top Affiliating Genes
1 chemical synaptic transmission GO:0007268 9.81 CRH HTR4 HTR7 TAC1
2 defense response to bacterium GO:0042742 9.78 CHGA IL10 TLR9 TNF
3 response to organic substance GO:0010033 9.74 IL10 SLC6A4 TNF
4 circadian rhythm GO:0007623 9.72 HTR7 SLC6A4 TPH1
5 regulation of blood pressure GO:0008217 9.67 CHGA GNB3 TAC1
6 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.59 IL10 TNF
7 positive regulation of chemokine production GO:0032722 9.58 TLR9 TNF
8 negative regulation of growth of symbiont in host GO:0044130 9.58 IL10 TNF
9 response to molecule of bacterial origin GO:0002237 9.56 IL10 TLR9
10 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.54 IL10 TNF
11 parturition GO:0007567 9.52 CRH CRHR1
12 endothelial cell apoptotic process GO:0072577 9.46 IL10 TNF
13 negative regulation of interleukin-6 production GO:0032715 9.43 IL10 TLR9 TNF
14 negative regulation of cytokine secretion involved in immune response GO:0002740 9.4 IL10 TNF
15 negative regulation of interleukin-8 production GO:0032717 9.37 IL10 TLR9
16 receptor biosynthetic process GO:0032800 9.32 IL10 TNF
17 positive regulation of corticosterone secretion GO:2000854 9.16 CRH TAC1
18 response to pain GO:0048265 9.13 CRH TAC1 TRPV1
19 inflammatory response GO:0006954 9.1 CRH IL10 TAC1 TLR9 TNF TRPV1
20 signal transduction GO:0007165 10.09 CCK CCKAR CRH CRHR1 GNB3 HTR3E

Molecular functions related to Irritable Bowel Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.43 CCK CRH MLN
2 serotonin binding GO:0051378 9.16 HTR3A HTR7
3 serotonin-gated cation channel activity GO:0022850 8.96 HTR3A HTR3E
4 G-protein coupled serotonin receptor activity GO:0004993 8.8 HTR3A HTR4 HTR7

Sources for Irritable Bowel Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
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