MCID: IRR003
MIFTS: 43

Irritant Dermatitis

Categories: Skin diseases

Aliases & Classifications for Irritant Dermatitis

Summaries for Irritant Dermatitis

MalaCards based summary : Irritant Dermatitis, also known as dermatitis, irritant, is related to antley-bixler syndrome with genital anomalies and disordered steroidogenesis and granuloma inguinale. An important gene associated with Irritant Dermatitis is IL1A (Interleukin 1 Alpha), and among its related pathways/superpathways are Developmental Biology and Allograft rejection. The drugs Glycerol and Tacrolimus have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and breast.

Wikipedia : 72 Irritant contact dermatitis is a form of contact dermatitis that can be divided into forms caused by... more...

Related Diseases for Irritant Dermatitis

Diseases related to Irritant Dermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 104)
id Related Disease Score Top Affiliating Genes
1 antley-bixler syndrome with genital anomalies and disordered steroidogenesis 10.7 FLG IER3IP1
2 granuloma inguinale 10.7 IER3IP1 IL1A
3 boylan dew greco syndrome 10.7 FLG KRT16
4 small intestine lymphoma 10.6 IL1A TNF
5 epstein-barr virus hepatitis 10.6 IL1A TNF
6 toxic optic neuropathy 10.6 IL1A IL1B
7 aids wasting syndrome 10.6 FLG KRT16
8 euthyroid sick syndrome 10.6 IER3IP1 TNF
9 gliosarcoma 10.6 IL1A IL1B
10 dermatitis 10.6
11 papilledema 10.6 KRT16 TNF
12 atrichia with papular lesions 10.6 IL1A TNF
13 urethra transitional cell carcinoma 10.5 IL1A TNF
14 primary biliary cirrhosis 10.5 IL1A TNF
15 liver disease 10.5 IL1A IL1B
16 spastic entropion 10.5 IER3IP1 IL1A
17 mental retardation dysmorphism hypogonadism diabetes 10.5 IL1A IL1B
18 tabatznik syndrome 10.5 IL1B TNF
19 sternal cleft 10.5 IL1B TNF
20 pulmonary hypertension 10.5 IL1B TNF
21 walker dyson syndrome 10.5 IL1B TNF
22 cataract 10.5 IL1B TNF
23 pityriasis rosea 10.4 IER3IP1 TNF
24 hypotrichosis-lymphedema-telangiectasia-renal defect syndrome 10.4 IL1B TNF
25 acute vascular insufficiency of intestine 10.4 FLG TNF
26 upper gum cancer 10.4 IL1B TNF
27 moved to 244450 10.4 IL1B TNF
28 bipolar i disorder 10.4 IL1B TNF
29 amyotrophic lateral sclerosis type 10 10.4 IL1B TNF
30 tinea favosa 10.4 IL1B TNF
31 central nervous system leiomyosarcoma 10.4 IL1B TNF
32 epulis 10.4 IL1B TNF
33 indolent myeloma 10.4 IL1B TNF
34 ileocolitis 10.4 IL1B TNF
35 palmoplantar keratoderma, nonepidermolytic, focal 10.4 FLG KRT16
36 early-onset zonular cataract 10.4 IL1B TNF
37 senile reticular retinal degeneration 10.4 IL1B TNF
38 yao syndrome 10.3 IL1B TNF
39 acquired thrombocytopenia 10.3 IL1B TNF
40 ampulla of vater neoplasm 10.3 IL1B TNF
41 megaloblastic anemia 10.3 IL1B TNF
42 benign neonatal seizures 10.3 IL1B TNF
43 arthus reaction 10.3 IL1B TNF
44 pyridoxal 5'-phosphate-dependent epilepsy 10.3 PI3 TNF
45 hemangioma of orbit 10.3 PI3 TNF
46 central sleep apnea 10.3 FLG KRT16 TNF
47 tetanus 10.3 PI3 TNF
48 keloids 10.3 IL1B TNF
49 familial mediterranean fever, ad 10.2 IL1B TNF
50 small non-cleaved cell lymphoma 10.2 FLG KRT16 TNF

Graphical network of the top 20 diseases related to Irritant Dermatitis:



Diseases related to Irritant Dermatitis

Symptoms & Phenotypes for Irritant Dermatitis

Drugs & Therapeutics for Irritant Dermatitis

Drugs for Irritant Dermatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 58)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Glycerol Approved, Investigational Phase 4 56-81-5 753
2
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492
3
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
4
Adapalene Approved Phase 4 106685-40-9 60164
5
Benzoyl peroxide Approved Phase 4 94-36-0 7187
6
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
7
Menthol Approved Phase 4 2216-51-5 16666
8
Zinc Approved Phase 4 7440-66-6 32051 23994
9
Zinc oxide Approved Phase 4 1314-13-2
10
Clobetasol Investigational Phase 4 25122-46-7, 25122-41-2 32798 5311051
11 Anti-Inflammatory Agents Phase 4,Phase 2
12 Calcineurin Inhibitors Phase 4
13 glucocorticoids Phase 4
14 Hormone Antagonists Phase 4
15 Hormones Phase 4
16 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
17 Immunosuppressive Agents Phase 4
18 Protective Agents Phase 4
19 triamcinolone acetonide Phase 4
20 Triamcinolone diacetate Phase 4
21 Triamcinolone hexacetonide Phase 4
22 Adapalene, Benzoyl Peroxide Drug Combination Phase 4
23 Analgesics Phase 4,Phase 2
24 Analgesics, Non-Narcotic Phase 4,Phase 2
25 Anti-Bacterial Agents Phase 4
26 Anti-Infective Agents Phase 4
27 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2
28 Antirheumatic Agents Phase 4,Phase 2
29 Clindamycin palmitate Phase 4
30 Clindamycin phosphate Phase 4
31 Dermatologic Agents Phase 4,Phase 2
32 Peripheral Nervous System Agents Phase 4,Phase 2
33 Antipruritics Phase 4
34 Micronutrients Phase 4
35 Radiation-Protective Agents Phase 4
36 Sunscreening Agents Phase 4
37 Trace Elements Phase 4
38 Aloe Nutraceutical Phase 3
39
Petrolatum Approved Phase 2 8009-03-8
40
Ustekinumab Approved, Investigational Phase 2 815610-63-0
41 Parthenolide Investigational Phase 2 20554-84-1
42 Antibodies Phase 2
43 Antibodies, Monoclonal Phase 2
44 Immunoglobulins Phase 2
45 Interleukin-12 Phase 2
46
chenodeoxycholic acid Approved 474-25-9 10133
47
deoxycholic acid Approved 83-44-3 222528
48 Coconut Approved, Nutraceutical
49 Emollients
50 Bile Acids and Salts

Interventional clinical trials:

(show all 23)

id Name Status NCT ID Phase Drugs
1 Efficacy of Glycerol, Two Topical Steroids, and a Topical Immune Modulator Against Skin Irritation Unknown status NCT00779792 Phase 4 clobetasol;triamcinolone acetonide;tacrolimus;glycerol;vehicle ointment (paraffin oil/soft white paraffin)
2 A Comparative Study of the Tolerability of Two Combination Therapies for the Treatment of Acne Completed NCT00887484 Phase 4 BENZOYL PEROXIDE/ CLINDAMYCIN;BENZOYL PEROXIDE/ ADAPALENE
3 A Study to Evaluate Tolerability of Two Topical Drug Products in the Treatment of Facial Acne Completed NCT00964223 Phase 4 Clindamycin and benzoyl peroxide gel (Duac® Topical Gel);benzoyl peroxide and adapalene gel (EPIDUO™ Gel)
4 Trial Comparing Calmoseptine Ointment and Desitin Diaper Rash Paste in Diaper Dermatitis in Neonates and Infants Recruiting NCT02716415 Phase 4 Calmoseptine Ointment;Destin Maximum Strength 40% Zinc
5 Investigating the Therapeutic Effectiveness of Aloe Barbadensis in Reducing Cutaneous Side-Effects of Radiation Treatment for Breast Cancer. Completed NCT00156806 Phase 3
6 Clinical Evaluation of the 3 Allergens: Methyldibromoglutharonitrile, Parthenolide and Goldnatriumthiosulphate Completed NCT00133341 Phase 2 Goldnatriomthiosulphate, MDBGN, parthenolide
7 RTA 408 Lotion in Patients at Risk for Radiation Dermatitis - PRIMROSE Completed NCT02142959 Phase 2 Omaveloxolone Lotion 0.5%;Omaveloxolone Lotion 3%;Lotion vehicle/Placebo
8 Clinical Evaluation of Lyral® Dose Response Study Completed NCT02028182 Phase 2
9 Pilot Study of Ustekinumab for Subjects With Chronic Atopic Dermatitis Active, not recruiting NCT01806662 Phase 2 Ustekinumab
10 A Randomised Clinical Trial in a Population of Health Care Workers With Hand Eczema Unknown status NCT01012453
11 Evaluation of Irritancy/Allergic Sensitivity to Natural Personal-care Products by Patch Tests Unknown status NCT01816542
12 Regional Differences of Cutaneous Irritation and Its Effect on Skin Barrier Recovery Completed NCT03231813
13 Effect of Tetrix on Alleviation of Burning,Itching Associated With Lesions of Contact Dermatitis Completed NCT00646867
14 Risk Factors for Incontinence-Associated Dermatitis (IAD) in ICU Patients Suffering From Fecal Incontinence Completed NCT02996357
15 Infant Fecal Insult Study Completed NCT02979210
16 FiteBac Hand Sanitizer in the Management of Hand Dermatitis in Adults Completed NCT01950494
17 Epicutaneous Testing of Cosmetics Recruiting NCT03024671
18 The Use of Coconut Oil for the Prevention and Treatment of Diaper Dermatitis in the NICU Population Recruiting NCT02614248
19 Comparison of Barrier Products in the Prevention of Incontinence-associated Dermatitis in Hospitalized Elderly Recruiting NCT03309059
20 Comparison of Wash Wipes and Standard Care in the Prevention of Incontinence-associated Dermatitis in Elderly Terminated NCT02475512
21 Preliminary Evaluation of CASTLE Barrier Prototype UK Terminated NCT01530087
22 CeraVe Cream Compared to Desitin Paste for Treating Diaper Dermatitis in Infants Terminated NCT02299206 CeraVe Baby Diaper Rash Cream;Desitin Maximum Strength Original Paste
23 Vulvar Contact Dermatitis Resulting From Urine Incontinence Withdrawn NCT01320046

Search NIH Clinical Center for Irritant Dermatitis

Cochrane evidence based reviews: dermatitis, irritant

Genetic Tests for Irritant Dermatitis

Anatomical Context for Irritant Dermatitis

MalaCards organs/tissues related to Irritant Dermatitis:

39
Skin, Testes, Breast

Publications for Irritant Dermatitis

Articles related to Irritant Dermatitis:

(show top 50) (show all 74)
id Title Authors Year
1
Topical ROR inverse agonists suppress inflammation in mouse models of atopic dermatitis and acute irritant dermatitis. ( 28774591 )
2017
2
Preapplication of white petroleum jelly to adjacent skin to prevent aluminum chloride-induced irritant dermatitis. ( 28619576 )
2017
3
N-acyl ethanolamide and eicosanoid involvement in irritant dermatitis. ( 26947140 )
2016
4
To evaluate the efficacy and safety of "RV2427B" cream in Irritant dermatitis care. ( 23984228 )
2013
5
IL-6 deficiency exacerbates skin inflammation in a murine model of irritant dermatitis. ( 22966985 )
2013
6
Hand hygiene compliance and irritant dermatitis: a juxtaposition of healthcare issues. ( 22691060 )
2012
7
Oxidative stress in allergic and irritant dermatitis: from basic research to clinical management. ( 22827837 )
2012
8
Contact irritant dermatitis in Kenya. ( 23472569 )
2012
9
Allergic and irritant dermatitis: pathogenic and management aspects. ( 22827836 )
2012
10
IL-6, VEGF, KC and RANTES are a major cause of a high irritant dermatitis to phthalic anhydride in C57BL/6 inbred mice. ( 20864798 )
2010
11
Hair highlights and severe acute irritant dermatitis ("burn") of the scalp. ( 20854194 )
2010
12
WOC nurse consult: Moist, painful peristomal skin. Chemical irritant dermatitis and pseudoverrucous lesions. ( 20228658 )
2010
13
Povidone iodine irritant dermatitis. ( 20606840 )
2010
14
Irritant Dermatitis to Staphylinid Beetle in Indian Troops in Congo. ( 27375320 )
2010
15
Contact irritant dermatitis from insect secretions: report of 74 cases in a military unit in Eritrea. ( 19731793 )
2009
16
Recurrent cyclic hyperkeratotic eczema after occupational alkali burn: traumatic chronic irritant dermatitis. ( 19489972 )
2009
17
Treatment with pimecrolimus cream 1% clears irritant dermatitis of the periocular region, face and neck. ( 18937664 )
2008
18
The effect of irritant dermatitis on cutaneous bioavailability of a metronidazole formulation, investigated by microdialysis and dermatopharmacokinetic method. ( 18537995 )
2008
19
Occlusive irritant dermatitis: when is "allergic" contact dermatitis not allergic? ( 17366682 )
2007
20
Contact and primary irritant dermatitis of the nail unit diagnosis and treatment. ( 17403259 )
2007
21
Moisturizer effect on irritant dermatitis: an overview. ( 16930228 )
2006
22
Effectiveness of a hand care regimen with moisturizer in manufacturing facilities where workers are prone to occupational irritant dermatitis. ( 15573643 )
2004
23
Contact irritant dermatitis and anti-pruritic agents: the need to address the itch. ( 12852365 )
2003
24
Irritant dermatitis to detergents in textiles. ( 12882025 )
2003
25
Irritant dermatitis due to prolonged contact with Oilatum Plus. ( 12534617 )
2003
26
Irritant dermatitis, irritancy and its role in allergic contact dermatitis. ( 11952708 )
2002
27
Sea water or its components alter experimental irritant dermatitis in man. ( 11301639 )
2001
28
Successfully managing incontinence-related irritant dermatitis across the lifespan. ( 10347509 )
1999
29
Crystal deodorant dermatitis: irritant dermatitis to alum-containing deodorant. ( 10431678 )
1999
30
Human barrier recovery after acute acetone perturbation: an irritant dermatitis model. ( 9667101 )
1998
31
Arachidonic acid metabolism in primary irritant dermatitis produced by patch testing of human skin with surfactants. ( 9875300 )
1998
32
Kerosene - Induced Acute Irritant Dermatitis (le). ( 20921732 )
1998
33
What's new in irritant dermatitis. ( 9255463 )
1997
34
Predictive testing in contact dermatitis. Irritant dermatitis. ( 9255475 )
1997
35
Pigmented and hyperkeratotic napkin dermatitis: a liquid detergent irritant dermatitis. ( 8864616 )
1996
36
Irritant dermatitis: experimental aspects. ( 9035907 )
1995
37
Sodium hydroxide-induced irritant dermatitis as assessed by computerized elaboration of 20 MHz B-scan images and by TEWL measurement: a method for investigating skin barrier function. ( 7604663 )
1995
38
Acute irritant dermatitis: effect of short-term topical corticoid treatment. ( 7587340 )
1995
39
Irritant dermatitis among workers cleaning up a pesticide spill: California 1991. ( 7793424 )
1995
40
Electrical impedance measured to five skin depths in mild irritant dermatitis induced by sodium lauryl sulphate. ( 7772476 )
1995
41
Irritant dermatitis in the workplace. ( 7923942 )
1994
42
The causes of irritant dermatitis. ( 8240913 )
1993
43
Moisturizers prevent irritant dermatitis. ( 1350143 )
1992
44
Susceptibility of atopic dermatitis patients to irritant dermatitis caused by sodium lauryl sulphate. ( 1681644 )
1991
45
Increased stratum corneum turnover induced by subclinical irritant dermatitis. ( 2369560 )
1990
46
Susceptibility to irritant dermatitis induced by sodium lauryl sulfate. ( 2365862 )
1990
47
Cumulative irritant dermatitis and abnormal epidermal plasminogen activator activity: what connection? ( 2531125 )
1989
48
Quantification of sodium lauryl sulfate irritant dermatitis in man: comparison of four techniques: skin color reflectance, transepidermal water loss, laser Doppler flow measurement and visual scores. ( 2774663 )
1989
49
Pustular irritant dermatitis due to croton oil. Evaluation of the role played by leukocytes and complement. ( 2455422 )
1988
50
Susceptibility to cumulative and acute irritant dermatitis. An experimental approach in human volunteers. ( 3180788 )
1988

Variations for Irritant Dermatitis

Expression for Irritant Dermatitis

Search GEO for disease gene expression data for Irritant Dermatitis.

Pathways for Irritant Dermatitis

Pathways related to Irritant Dermatitis according to GeneCards Suite gene sharing:

(show all 29)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.27 FLG KRT16 LCE2B PI3 PKP3 TNF
2
Show member pathways
12.65 IL1A IL1B MS4A2 TNF
3
Show member pathways
12.07 IL1A IL1B TNF
4
Show member pathways
12.07 IL1A IL1B TNF
5 12.04 IL1A IL1B TNF
6 11.98 IL1A IL1B TNF
7
Show member pathways
11.94 IL1A IL1B TNF
8 11.89 IL1A IL1B TNF
9 11.83 IL1A IL1B TNF
10 11.78 IL1A IL1B TNF
11 11.74 IL1A IL1B TNF
12 11.67 IL1A IL1B TNF
13 11.64 IL1A IL1B TNF
14 11.59 IL1A IL1B TNF
15 11.49 IL1A IL1B TNF
16
Show member pathways
11.48 FLG KRT16 LCE2B PI3 PKP3
17
Show member pathways
11.34 IL1A IL1B TNF
18 11.19 IL1B TNF
19 11.19 IL1A IL1B TNF
20 11.18 IL1A IL1B
21 11.14 IL1B TNF
22 11.12 IL1B TNF
23 11.09 IL1A IL1B TNF
24 11.02 IL1A IL1B TNF
25 10.93 IL1B TNF
26 10.88 IL1A IL1B TNF
27 10.74 IL1B TNF
28 10.61 IL1A IL1B TNF
29 10.25 IL1A IL1B

GO Terms for Irritant Dermatitis

Cellular components related to Irritant Dermatitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cornified envelope GO:0001533 8.92 FLG LCE2B PI3 PKP3

Biological processes related to Irritant Dermatitis according to GeneCards Suite gene sharing:

(show all 34)
id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.92 IL1A IL1B MS4A2 TNF
2 positive regulation of gene expression GO:0010628 9.88 IL1A IL1B PKP3 TNF
3 keratinization GO:0031424 9.83 KRT16 LCE2B PKP3
4 keratinocyte differentiation GO:0030216 9.67 FLG KRT16 LCE2B
5 protein kinase B signaling GO:0043491 9.66 IL1B TNF
6 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.66 IL1A IL1B
7 lipopolysaccharide-mediated signaling pathway GO:0031663 9.65 IL1B TNF
8 positive regulation of phagocytosis GO:0050766 9.65 IL1B TNF
9 positive regulation of cytokine secretion GO:0050715 9.64 IL1A TNF
10 positive regulation of interleukin-8 production GO:0032757 9.64 IL1B TNF
11 positive regulation of vascular endothelial growth factor production GO:0010575 9.63 IL1A IL1B
12 positive regulation of mitotic nuclear division GO:0045840 9.63 IL1A IL1B
13 positive regulation of interleukin-6 secretion GO:2000778 9.62 IL1B NLRP10
14 positive regulation of NF-kappaB import into nucleus GO:0042346 9.61 IL1B TNF
15 establishment of skin barrier GO:0061436 9.61 FLG KRT16
16 negative regulation of lipid catabolic process GO:0050995 9.6 IL1B TNF
17 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.59 IL1B TNF
18 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.58 IL1B TNF
19 peptide cross-linking GO:0018149 9.58 FLG LCE2B PI3
20 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.57 IL1B TNF
21 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.56 IL1A IL1B
22 positive regulation of chemokine biosynthetic process GO:0045080 9.55 IL1B TNF
23 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.54 IL1A IL1B
24 skin epidermis development GO:0098773 9.52 FLG PI3
25 ectopic germ cell programmed cell death GO:0035234 9.51 IL1A IL1B
26 positive regulation of interleukin-6 production GO:0032755 9.5 IL1A IL1B TNF
27 regulation of establishment of endothelial barrier GO:1903140 9.48 IL1B TNF
28 fever generation GO:0001660 9.46 IL1A IL1B
29 positive regulation of fever generation GO:0031622 9.43 IL1B TNF
30 sequestering of triglyceride GO:0030730 9.37 IL1B TNF
31 inflammatory response GO:0006954 9.35 IL1A IL1B KRT16 MS4A2 TNF
32 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.33 IL1A IL1B TNF
33 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.26 IL1B TNF
34 cornification GO:0070268 8.92 FLG KRT16 PI3 PKP3

Molecular functions related to Irritant Dermatitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.33 IL1A IL1B TNF
2 interleukin-1 receptor binding GO:0005149 8.96 IL1A IL1B
3 structural constituent of epidermis GO:0030280 8.62 FLG PI3

Sources for Irritant Dermatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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