MCID: IRR003
MIFTS: 44

Irritant Dermatitis malady

Categories: Skin diseases

Aliases & Classifications for Irritant Dermatitis

Summaries for Irritant Dermatitis

MalaCards based summary : Irritant Dermatitis, also known as dermatitis, irritant, is related to dermatitis and toxic optic neuropathy. An important gene associated with Irritant Dermatitis is IL1A (Interleukin 1 Alpha), and among its related pathways/superpathways are Allograft rejection and Keratinization. The drugs Tacrolimus and Glycerol have been mentioned in the context of this disorder. Affiliated tissues include skin and testes.

Wikipedia : 71 Irritant contact dermatitis is a form of contact dermatitis that can be divided into forms caused by... more...

Related Diseases for Irritant Dermatitis

Diseases related to Irritant Dermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 71)
id Related Disease Score Top Affiliating Genes
1 dermatitis 10.6
2 toxic optic neuropathy 10.3 IL1A IL1B
3 brachydactyly small stature face anomalies 10.2 FLG KRT16
4 small non-cleaved cell lymphoma 10.2 IL1A TNF
5 swine influenza 10.2 IL1A TNF
6 intussusception 10.2 IL1B TNF
7 tau syndrome 10.2 IL1B TNF
8 stocco dos santos syndrome 10.2 IL1B TNF
9 hypotrichosis-lymphedema-telangiectasia-renal defect syndrome 10.2 IL1B TNF
10 twin-to-twin transfusion syndrome 10.2 IL1B TNF
11 papilledema 10.2 KRT16 TNF
12 warthin tumor 10.2 IL1B TNF
13 cataract 10.1 IL1B TNF
14 hepatic encephalopathy 10.1 IL1B TNF
15 acute kidney failure 10.1 FLG IL1A TNF
16 anal paget's disease 10.1 IL1A IL1B TNF
17 steroid dehydrogenase deficiency dental anomalies 10.1 IL1A IL1B TNF
18 mikulicz disease 10.1 IL1A IL1B TNF
19 mast-cell leukemia 10.1 FLG KRT16 TNF
20 autosomal recessive type iv ehlers-danlos syndrome 10.1 IL1A IL1B TNF
21 bipolar i disorder 10.1 IL1B TNF
22 inappropriate adh syndrome 10.1 IL1A IL1B TNF
23 immunoglobulin g deficiency 10.1 IL1A IL1B TNF
24 skin conditions 10.1 IL1A IL1B TNF
25 nasopharyngitis 10.1 IL1A IL1B TNF
26 infancy electroclinical syndrome 10.1 IL1A IL1B TNF
27 stenosis of lacrimal sac 10.1 IL1A IL1B TNF
28 baritosis 10.1 IL1A IL1B TNF
29 classic type lipoma 10.1 IL1A IL1B TNF
30 radial defect robin sequence 10.1 PI3 TNF
31 bare lymphocyte syndrome, type i 10.1 IL1A IL1B TNF
32 human immunodeficiency virus infectious disease 10.1 IL1B TNF
33 bone angioendothelial sarcoma 10.1 IL1A IL1B TNF
34 erythematosquamous dermatosis 10.1 IL1A IL1B TNF
35 intracranial hemorrhage in brain cerebrovascular malformations 10.1 IL1A IL1B TNF
36 band keratopathy 10.1 IL1A IL1B TNF
37 hemangioma of orbit 10.1 PI3 TNF
38 nervous system cancer 10.1 IL1A IL1B TNF
39 balkan nephropathy 10.1 FLG IL1B TNF
40 histiocytosis 10.1 IL1A IL1B TNF
41 molybdenum cofactor deficiency a 10.1 IL1A IL1B TNF
42 intratubular embryonal carcinoma 10.1 IL1A IL1B TNF
43 peroneal neuropathy 10.1 IER3IP1 IL1B TNF
44 gangliosidosis gm2 10.1 FLG MS4A2 TNF
45 body dysmorphic disorder 10.1 IER3IP1 IL1B TNF
46 tetanus 10.1 PI3 TNF
47 tinea capitis 10.0 IL1B TNF
48 solitary bone cyst 10.0 FLG KRT16 TNF
49 thymus adenosquamous carcinoma 10.0 IL1A IL1B TNF
50 hypotrichosis 4 10.0 IL1A TNF

Graphical network of the top 20 diseases related to Irritant Dermatitis:



Diseases related to Irritant Dermatitis

Symptoms & Phenotypes for Irritant Dermatitis

Drugs & Therapeutics for Irritant Dermatitis

Drugs for Irritant Dermatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 85)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492
2
Glycerol Approved, Experimental Phase 4 56-81-5 753
3
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
4
Zinc Approved Phase 4,Phase 2 7440-66-6 32051 23994
5
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 1 22916-47-8 4189
6
Adapalene Approved Phase 4 106685-40-9 60164
7
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
8
Benzoyl peroxide Approved Phase 4 94-36-0 7187
9
Zinc oxide Approved Phase 4 1314-13-2
10
Menthol Approved Phase 4 2216-51-5 16666
11
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
12 triamcinolone acetonide Phase 4
13
Clobetasol Phase 4 25122-46-7 32798 5311051
14 glucocorticoids Phase 4
15 Hormone Antagonists Phase 4,Phase 1
16 Triamcinolone diacetate Phase 4
17 Triamcinolone hexacetonide Phase 4
18 Hormones Phase 4,Phase 1
19 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 1
20 Immunosuppressive Agents Phase 4
21 Protective Agents Phase 4,Phase 2
22 Anti-Inflammatory Agents Phase 4,Phase 2
23 Calcineurin Inhibitors Phase 4
24 Analgesics Phase 4,Phase 2
25 Adapalene, Benzoyl Peroxide Drug Combination Phase 4
26 Clindamycin palmitate Phase 4
27 Clindamycin phosphate Phase 4
28 Steroid Synthesis Inhibitors Phase 4,Phase 1
29 Sunscreening Agents Phase 4,Phase 2
30 Cytochrome P-450 CYP2C9 Inhibitors Phase 4
31 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 1
32 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 1
33 Tocopherols Phase 4
34 Tocotrienols Phase 4
35 Analgesics, Non-Narcotic Phase 4,Phase 2
36 Dermatologic Agents Phase 4,Phase 1,Phase 2
37 Trace Elements Phase 4
38 Peripheral Nervous System Agents Phase 4,Phase 2
39 Anti-Bacterial Agents Phase 4,Phase 1
40 Vitamins Phase 4
41 Anti-Infective Agents Phase 4,Phase 1
42 Antifungal Agents Phase 4,Phase 1
43 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2
44 Radiation-Protective Agents Phase 4,Phase 2
45 Micronutrients Phase 4
46 Antirheumatic Agents Phase 4,Phase 2
47 Antioxidants Phase 4
48 Antipruritics Phase 4
49 Tocopherol Nutraceutical Phase 4
50 Tocotrienol Nutraceutical Phase 4

Interventional clinical trials:

(show all 41)
id Name Status NCT ID Phase
1 Efficacy of Glycerol, Two Topical Steroids, and a Topical Immune Modulator Against Skin Irritation Unknown status NCT00779792 Phase 4
2 Prospective Two-Year Study to Assess Miconazole Nitrate Resistance in Neonates and Infants Completed NCT00702507 Phase 4
3 Clinical Study to Evaluate the Efficacy and Safety of Two Marketed Investigational Products in Children With Diaper Rash Completed NCT00219466 Phase 4
4 A Comparative Study of the Tolerability of Two Combination Therapies for the Treatment of Acne Completed NCT00887484 Phase 4
5 A Study to Evaluate Tolerability of Two Topical Drug Products in the Treatment of Facial Acne Completed NCT00964223 Phase 4
6 Trial Comparing Calmoseptine Ointment and Desitin Diaper Rash Paste in Diaper Dermatitis in Neonates and Infants Recruiting NCT02716415 Phase 4
7 Determination of Safety and Consumers' Satisfaction of Moussik Versus Desitin Creamy Ointment in Diaper Rash Prophylaxis Withdrawn NCT01167465 Phase 4
8 Investigating the Therapeutic Effectiveness of Aloe Barbadensis in Reducing Cutaneous Side-Effects of Radiation Treatment for Breast Cancer. Completed NCT00156806 Phase 3
9 Clinical Evaluation of the 3 Allergens: Methyldibromoglutharonitrile, Parthenolide and Goldnatriumthiosulphate Completed NCT00133341 Phase 2
10 RTA 408 Lotion in Patients at Risk for Radiation Dermatitis - PRIMROSE Completed NCT02142959 Phase 2
11 Clinical Evaluation of Lyral® Dose Response Study Completed NCT02028182 Phase 2
12 COLLAGEN CROSS-LINKING WITH ULTRAVIOLET-A IN ASYMMETRIC CORNEAS Recruiting NCT03029104 Phase 2
13 Superficial Basal Cell Cancer's Photodynamic Therapy: Comparing Three Photosensitises: HAL and BF-200 ALA Versus MAL Recruiting NCT02367547 Phase 1, Phase 2
14 Pilot Study of Ustekinumab for Subjects With Chronic Atopic Dermatitis Active, not recruiting NCT01806662 Phase 2
15 Clinical Evaluation of Metal Panel Allergens: Dose Response Study Not yet recruiting NCT02615249 Phase 2
16 Efficacy and Safety of a Sunscreen Against Porfimer Sodium-induced Phototoxicity to Visible Light Withdrawn NCT01256203 Phase 2
17 A Study Evaluating Skin Irritation, Phototoxicity and Safety After Administration of LEO 90105 on Intact Skin of Healthy Japanese Male Subjects Completed NCT01293357 Phase 1
18 A Pilot of Pediatric/Adult Study of Gene Expression Profiling and Clinical Characterization of Phototoxicity Completed NCT00353158 Phase 1
19 A Randomised Clinical Trial in a Population of Health Care Workers With Hand Eczema Unknown status NCT01012453
20 Evaluation of Irritancy/Allergic Sensitivity to Natural Personal-care Products by Patch Tests Unknown status NCT01816542
21 Effect of Tetrix on Alleviation of Burning,Itching Associated With Lesions of Contact Dermatitis Completed NCT00646867
22 Human Phototoxicity Test (823/2016) Completed NCT02962856
23 18348-Human Phototoxicity Test Completed NCT02823483
24 Test the Phototoxicity of Sunscreen Products Completed NCT02802930
25 Human Phototoxicity Test Completed NCT02754102
26 Human Phototoxicity Test Completed NCT02751541
27 Human Phototoxicity Test Completed NCT02751489
28 Human Phototoxicity Test Completed NCT02750475
29 FiteBac Hand Sanitizer in the Management of Hand Dermatitis in Adults Completed NCT01950494
30 Risk Factors for Incontinence-Associated Dermatitis (IAD) in ICU Patients Suffering From Fecal Incontinence Recruiting NCT02996357
31 The Use of Coconut Oil for the Prevention and Treatment of Diaper Dermatitis in the NICU Population Recruiting NCT02614248
32 BM Characterization Pilot Recruiting NCT03138057
33 Prevention of Phototoxicities in Patients Undergoing Vemurafenib Treatment Recruiting NCT03108209
34 Epicutaneous Testing of Cosmetics Recruiting NCT03024671
35 BM Collection From NICU Infants for Composition Active, not recruiting NCT02570698
36 Infant Microbiome in Diaper Rash Active, not recruiting NCT02893501
37 Infant Fecal Insult Study Active, not recruiting NCT02979210
38 Comparison of Wash Wipes and Standard Care in the Prevention of Incontinence-associated Dermatitis in Elderly Terminated NCT02475512
39 Preliminary Evaluation of CASTLE Barrier Prototype UK Terminated NCT01530087
40 CeraVe Cream Compared to Desitin Paste for Treating Diaper Dermatitis in Infants Terminated NCT02299206
41 Vulvar Contact Dermatitis Resulting From Urine Incontinence Withdrawn NCT01320046

Search NIH Clinical Center for Irritant Dermatitis

Cochrane evidence based reviews: dermatitis, irritant

Genetic Tests for Irritant Dermatitis

Anatomical Context for Irritant Dermatitis

MalaCards organs/tissues related to Irritant Dermatitis:

39
Skin, Testes

Publications for Irritant Dermatitis

Articles related to Irritant Dermatitis:

(show top 50) (show all 72)
id Title Authors Year
1
N-acyl ethanolamide and eicosanoid involvement in irritant dermatitis. ( 26947140 )
2016
2
To evaluate the efficacy and safety of "RV2427B" cream in Irritant dermatitis care. ( 23984228 )
2013
3
IL-6 deficiency exacerbates skin inflammation in a murine model of irritant dermatitis. ( 22966985 )
2013
4
Hand hygiene compliance and irritant dermatitis: a juxtaposition of healthcare issues. ( 22691060 )
2012
5
Allergic and irritant dermatitis: pathogenic and management aspects. ( 22827836 )
2012
6
Contact irritant dermatitis in Kenya. ( 23472569 )
2012
7
Oxidative stress in allergic and irritant dermatitis: from basic research to clinical management. ( 22827837 )
2012
8
Povidone iodine irritant dermatitis. ( 20606840 )
2010
9
IL-6, VEGF, KC and RANTES are a major cause of a high irritant dermatitis to phthalic anhydride in C57BL/6 inbred mice. ( 20864798 )
2010
10
WOC nurse consult: Moist, painful peristomal skin. Chemical irritant dermatitis and pseudoverrucous lesions. ( 20228658 )
2010
11
Irritant Dermatitis to Staphylinid Beetle in Indian Troops in Congo. ( 27375320 )
2010
12
Hair highlights and severe acute irritant dermatitis ("burn") of the scalp. ( 20854194 )
2010
13
Contact irritant dermatitis from insect secretions: report of 74 cases in a military unit in Eritrea. ( 19731793 )
2009
14
Recurrent cyclic hyperkeratotic eczema after occupational alkali burn: traumatic chronic irritant dermatitis. ( 19489972 )
2009
15
The effect of irritant dermatitis on cutaneous bioavailability of a metronidazole formulation, investigated by microdialysis and dermatopharmacokinetic method. ( 18537995 )
2008
16
Treatment with pimecrolimus cream 1% clears irritant dermatitis of the periocular region, face and neck. ( 18937664 )
2008
17
Occlusive irritant dermatitis: when is "allergic" contact dermatitis not allergic? ( 17366682 )
2007
18
Contact and primary irritant dermatitis of the nail unit diagnosis and treatment. ( 17403259 )
2007
19
Moisturizer effect on irritant dermatitis: an overview. ( 16930228 )
2006
20
Effectiveness of a hand care regimen with moisturizer in manufacturing facilities where workers are prone to occupational irritant dermatitis. ( 15573643 )
2004
21
Irritant dermatitis due to prolonged contact with Oilatum Plus. ( 12534617 )
2003
22
Irritant dermatitis to detergents in textiles. ( 12882025 )
2003
23
Contact irritant dermatitis and anti-pruritic agents: the need to address the itch. ( 12852365 )
2003
24
Irritant dermatitis, irritancy and its role in allergic contact dermatitis. ( 11952708 )
2002
25
Sea water or its components alter experimental irritant dermatitis in man. ( 11301639 )
2001
26
Crystal deodorant dermatitis: irritant dermatitis to alum-containing deodorant. ( 10431678 )
1999
27
Successfully managing incontinence-related irritant dermatitis across the lifespan. ( 10347509 )
1999
28
Kerosene - Induced Acute Irritant Dermatitis (le). ( 20921732 )
1998
29
Human barrier recovery after acute acetone perturbation: an irritant dermatitis model. ( 9667101 )
1998
30
Arachidonic acid metabolism in primary irritant dermatitis produced by patch testing of human skin with surfactants. ( 9875300 )
1998
31
What's new in irritant dermatitis. ( 9255463 )
1997
32
Predictive testing in contact dermatitis. Irritant dermatitis. ( 9255475 )
1997
33
Pigmented and hyperkeratotic napkin dermatitis: a liquid detergent irritant dermatitis. ( 8864616 )
1996
34
Irritant dermatitis: experimental aspects. ( 9035907 )
1995
35
Irritant dermatitis among workers cleaning up a pesticide spill: California 1991. ( 7793424 )
1995
36
Acute irritant dermatitis: effect of short-term topical corticoid treatment. ( 7587340 )
1995
37
Sodium hydroxide-induced irritant dermatitis as assessed by computerized elaboration of 20 MHz B-scan images and by TEWL measurement: a method for investigating skin barrier function. ( 7604663 )
1995
38
Electrical impedance measured to five skin depths in mild irritant dermatitis induced by sodium lauryl sulphate. ( 7772476 )
1995
39
Irritant dermatitis in the workplace. ( 7923942 )
1994
40
The causes of irritant dermatitis. ( 8240913 )
1993
41
Moisturizers prevent irritant dermatitis. ( 1350143 )
1992
42
Susceptibility of atopic dermatitis patients to irritant dermatitis caused by sodium lauryl sulphate. ( 1681644 )
1991
43
Increased stratum corneum turnover induced by subclinical irritant dermatitis. ( 2369560 )
1990
44
Susceptibility to irritant dermatitis induced by sodium lauryl sulfate. ( 2365862 )
1990
45
Cumulative irritant dermatitis and abnormal epidermal plasminogen activator activity: what connection? ( 2531125 )
1989
46
Quantification of sodium lauryl sulfate irritant dermatitis in man: comparison of four techniques: skin color reflectance, transepidermal water loss, laser Doppler flow measurement and visual scores. ( 2774663 )
1989
47
Pustular irritant dermatitis due to croton oil. Evaluation of the role played by leukocytes and complement. ( 2455422 )
1988
48
Susceptibility to cumulative and acute irritant dermatitis. An experimental approach in human volunteers. ( 3180788 )
1988
49
Irritant dermatitis from tri-butyl tin oxide and contact allergy from chlorocresol. ( 2960483 )
1987
50
Prevention of irritant dermatitis. ( 2956714 )
1986

Variations for Irritant Dermatitis

Expression for Irritant Dermatitis

Search GEO for disease gene expression data for Irritant Dermatitis.

Pathways for Irritant Dermatitis

Pathways related to Irritant Dermatitis according to GeneCards Suite gene sharing:

(show all 28)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.64 IL1A IL1B MS4A2 TNF
2
Show member pathways
12.19 FLG KRT16 LCE5A PI3
3
Show member pathways
12.06 IL1A IL1B TNF
4
Show member pathways
12.06 IL1A IL1B TNF
5 12.03 IL1A IL1B TNF
6 11.97 IL1A IL1B TNF
7
Show member pathways
11.94 IL1A IL1B TNF
8 11.89 IL1A IL1B TNF
9 11.83 IL1A IL1B TNF
10 11.78 IL1A IL1B TNF
11 11.74 IL1A IL1B TNF
12 11.67 IL1A IL1B TNF
13 11.64 IL1A IL1B TNF
14 11.59 IL1A IL1B TNF
15 11.46 IL1A IL1B TNF
16
Show member pathways
11.3 IL1A IL1B TNF
17 11.18 IL1B TNF
18 11.18 IL1A IL1B
19 11.13 IL1B TNF
20 11.12 IL1A IL1B TNF
21 11.11 IL1B TNF
22 11.02 IL1A IL1B TNF
23 10.99 IL1A IL1B TNF
24 10.92 IL1B TNF
25 10.74 IL1B TNF
26 10.68 IL1A IL1B TNF
27 10.28 IL1A IL1B TNF
28 10.21 IL1A IL1B

GO Terms for Irritant Dermatitis

Cellular components related to Irritant Dermatitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cornified envelope GO:0001533 8.8 FLG LCE5A PI3

Biological processes related to Irritant Dermatitis according to GeneCards Suite gene sharing:

(show all 32)
id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.92 IL1A IL1B MS4A2 TNF
2 cornification GO:0070268 9.74 FLG KRT16 PI3
3 protein kinase B signaling GO:0043491 9.65 IL1B TNF
4 lipopolysaccharide-mediated signaling pathway GO:0031663 9.65 IL1B TNF
5 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.65 IL1A IL1B
6 keratinocyte differentiation GO:0030216 9.65 FLG KRT16 LCE5A
7 positive regulation of phagocytosis GO:0050766 9.64 IL1B TNF
8 positive regulation of cytokine secretion GO:0050715 9.64 IL1A TNF
9 positive regulation of vascular endothelial growth factor production GO:0010575 9.63 IL1A IL1B
10 positive regulation of mitotic nuclear division GO:0045840 9.63 IL1A IL1B
11 positive regulation of interleukin-8 production GO:0032757 9.62 IL1B TNF
12 positive regulation of NF-kappaB import into nucleus GO:0042346 9.61 IL1B TNF
13 establishment of skin barrier GO:0061436 9.61 FLG KRT16
14 positive regulation of interleukin-6 secretion GO:2000778 9.6 IL1B NLRP10
15 negative regulation of lipid catabolic process GO:0050995 9.59 IL1B TNF
16 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.58 IL1B TNF
17 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.58 IL1B TNF
18 peptide cross-linking GO:0018149 9.58 FLG LCE5A PI3
19 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.56 IL1B TNF
20 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.55 IL1A IL1B
21 positive regulation of chemokine biosynthetic process GO:0045080 9.54 IL1B TNF
22 skin epidermis development GO:0098773 9.52 FLG PI3
23 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.51 IL1A IL1B
24 positive regulation of interleukin-6 production GO:0032755 9.5 IL1A IL1B TNF
25 ectopic germ cell programmed cell death GO:0035234 9.49 IL1A IL1B
26 regulation of establishment of endothelial barrier GO:1903140 9.46 IL1B TNF
27 positive regulation of fever generation GO:0031622 9.43 IL1B TNF
28 sequestering of triglyceride GO:0030730 9.37 IL1B TNF
29 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.26 IL1B TNF
30 fever generation GO:0001660 9.16 IL1A IL1B
31 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.13 IL1A IL1B TNF
32 inflammatory response GO:0006954 9.02 IL1A IL1B KRT16 MS4A2 TNF

Molecular functions related to Irritant Dermatitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.33 IL1A IL1B TNF
2 interleukin-1 receptor binding GO:0005149 8.96 IL1A IL1B
3 structural constituent of epidermis GO:0030280 8.62 FLG PI3

Sources for Irritant Dermatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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