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12Gene Ontology
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Cellular components related to ischemia according to GeneDecks: (show all 18)
| id | Name | GO ID | Score | Top Affiliating Genes | | 1 | membrane | GO:016020 | INF | PIK3CG, PDE4A, REN, CNTN1, PCSK2, SELPLG | | 2 | cytoplasm | GO:005737 | INF | PIK3C2A, PIK3CG, WDR26, RELA, SGCB, KITLG | | 3 | plasma membrane | GO:005886 | INF | PIK3C2A, PIK3CG, , NCAM1, SGK1, CNR1 | | 4 | mitochondrion | GO:005739 | INF | SGK1, PC, GCK, BSG, VHL, BNIP3 | | 5 | integral to plasma membrane | GO:005887 | INF | SGCB, CNR1, CNR2, SELL, SELP, SELPLG | | 6 | external side of plasma membrane | GO:009897 | 14.6 | NCAM1, VWF, SELL, SELP, VCAM1, KDR | | 7 | secretory granule | GO:030141 | 12.3 | PCSK2, GCK, GCG, VEGFA, SCG5, AVP | | 8 | extracellular space | GO:005615 | INF | REN, CNTF, KITLG, VTN, PCSK2, GCG | | 9 | neuronal cell body | GO:043025 | INF | CNTF, MYLK2, CHAT, CHRNA4, UCN, S100B | | 10 | extracellular region | GO:005576 | INF | , NDFIP1, NCAM1, RETN, KITLG, VWF | | 11 | membrane raft | GO:045121 | INF | SELE, BSG, LCK, P2RX7, JAK2, CD36 | | 12 | caveola | GO:005901 | INF | , SELE, SCN5A, ATP1A2, ATP1B1, JAK2 | | 13 | axon | GO:030424 | INF | CNTF, GC, VIM, MYC, PARK7, CHAT | | 14 | cytosol | GO:005829 | INF | PIK3C2A, PIK3CG, PDE4A, RELA, CNTF, GCK | | 15 | platelet alpha granule lumen | GO:031093 | INF | VWF, SERPINA1, SERPINE1, VEGFA, VEGFB, VEGFC | | 16 | perinuclear region of cytoplasm | GO:048471 | INF | NDFIP1, PDE4A, GC, SELE, LMNA, CLU | | 17 | cell surface | GO:009986 | INF | NCAM1, VEGFA, LPL, VCAM1, SCN5A, LDLR | | 18 | nucleoplasm | GO:005654 | INF | RELA, PCNA, GCK, VHL, LMNA, BNIP3 |
Biological processes related to ischemia according to GeneDecks: (show top 50)
(show all 77)
| id | Name | GO ID | Score | Top Affiliating Genes | | 1 | synaptic transmission | GO:007268 | INF | RAF1, UTS2, PANX2, PANX1, KCNB1, | | 2 | negative regulation of cell proliferation | GO:008285 | INF | KLF4, VHL, RAF1, LIF, BECN1, BDKRB2 | | 3 | signal transduction | GO:007165 | INF | , NDFIP1, PDE4A, CNTF, KITLG, GCG | | 4 | platelet activation | GO:030168 | INF | PIK3CG, VWF, SELP, SERPINA1, SERPINE1, VEGFA | | 5 | innate immune response | GO:045087 | 17.0 | PIK3CG, RELA, CLU, PANX1, BCL2, BCL2L1 | | 6 | anti-apoptosis | GO:006916 | 15.9 | RELA, VIMP, NAIP, VHL, VEGFB, BNIP3 | | 7 | angiogenesis | GO:001525 | 15.8 | PIK3CG, SETD2, SERPINE1, VEGFA, VEGFC, KDR | | 8 | response to lipopolysaccharide | GO:032496 | 15.2 | CNR1, CNR2, SELE, SELP, SERPINA1, S100A8 | | 9 | protein autophosphorylation | GO:046777 | 14.4 | MYLK2, BMX, KDR, ATM, FYN, JAK2 | | 10 | positive regulation of angiogenesis | GO:045766 | 14.2 | SERPINE1, VEGFA, UTS2, KDR, CD34, MMP9 | | 11 | response to ethanol | GO:045471 | 14.0 | CNR1, BCL2, CHAT, BAK1, S100A8, AVP | | 12 | activation of MAPK activity | GO:000187 | 14.0 | UBC, P2RX7, ITGA1, INSR, FGF2, GRM1 | | 13 | response to organic cyclic compound | GO:014070 | 13.9 | SELP, SERPINA1, BAK1, P2RX7, MSH2, JUN | | 14 | negative regulation of neuron apoptotic process | GO:043524 | 13.9 | CNTF, NAIP, VEGFB, PARK7, PARK2, BDNF | | 15 | aging | GO:007568 | 13.9 | CNR1, SERPINF1, VCAM1, BAK1, P2RY1, MSRA | | 16 | positive regulation of cell migration | GO:030335 | 13.8 | VEGFA, KDR, S1PR1, JAK2, ITGAV, MMP14 | | 17 | elevation of cytosolic calcium ion concentration | GO:007204 | 13.7 | GCK, UTS2, BDKRB2, P2RY1, AVP, AVPR1A | | 18 | MyD88-independent toll-like receptor signaling pathway | GO:002756 | 13.4 | RELA, CHUK, UBC, ATF2, JUN, FOS | | 19 | toll-like receptor 3 signaling pathway | GO:034138 | 13.3 | RELA, CHUK, UBC, ATF2, JUN, FOS | | 20 | positive regulation of ERK1 and ERK2 cascade | GO:070374 | 13.2 | GCG, VEGFB, KDR, MT3, P2RY1, FLT4 | | 21 | Toll signaling pathway | GO:008063 | 13.2 | RELA, CHUK, UBC, ATF2, JUN, FOS | | 22 | toll-like receptor signaling pathway | GO:002224 | 13.2 | RELA, CHUK, UBC, ATF2, JUN, FOS | | 23 | MyD88-dependent toll-like receptor signaling pathway | GO:002755 | 13.2 | RELA, CHUK, UBC, ATF2, JUN, FOS | | 24 | toll-like receptor 4 signaling pathway | GO:034142 | 13.2 | RELA, CHUK, UBC, ATF2, JUN, FOS | | 25 | positive regulation of neuron apoptotic process | GO:043525 | 13.2 | BCL2L11, BAG1, BAX, ATM, JUN, CDK5 | | 26 | toll-like receptor 1 signaling pathway | GO:034130 | 13.1 | RELA, CHUK, UBC, ATF2, JUN, FOS | | 27 | toll-like receptor 2 signaling pathway | GO:034134 | 13.1 | RELA, CHUK, UBC, ATF2, JUN, FOS | | 28 | stress-activated MAPK cascade | GO:051403 | 13.0 | UBC, ATF2, JUN, FOS, MEF2C, MAPK8 | | 29 | activation of cysteine-type endopeptidase activity involved in apoptotic process | GO:006919 | 12.8 | VCP, MYC, BCL2L11, BBC3, LCK, BAD | | 30 | response to glucocorticoid stimulus | GO:051384 | 12.8 | SERPINF1, SERPINE1, BCHE, BCKDHB, UCN, INSR | | 31 | positive regulation of I-kappaB kinase/NF-kappaB cascade | GO:043123 | 12.8 | NDFIP1, RELA, PARK2, CHUK, UBC, S100B | | 32 | positive regulation of MAPK cascade | GO:043410 | 12.5 | CNTF, LIF, KDR, LEP, P2RX7, CD36 | | 33 | response to estradiol stimulus | GO:032355 | 12.4 | GC, SERPINA1, UCN, MMP9, INSR, IL1B | | 34 | positive regulation of NF-kappaB transcription factor activity | GO:051092 | 12.1 | RELA, CLU, CHUK, UBC, MTPN, CD40 | | 35 | negative regulation of apoptotic process | GO:043066 | INF | PIK3CG, RELA, GCG, SERPINE1, VEGFA, MYC | | 36 | blood coagulation | GO:007596 | INF | PIK3CG, , VWF, SELL, SELP, SELPLG | | 37 | induction of apoptosis | GO:006917 | INF | BNIP3, BCL2L11, BBC3, LCK, BAD, BAX | | 38 | apoptotic process | GO:006915 | INF | SGK1, VIM, LMNA, BNIP3, BMX, RAF1 | | 39 | small molecule metabolic process | GO:044281 | INF | PIK3C2A, PIK3CG, PC, GCK, GCG, GC | | 40 | regulation of blood pressure | GO:008217 | INF | REN, SGK1, UTS2, LEP, ATP1A2, ATP1A1 | | 41 | nerve growth factor receptor signaling pathway | GO:048011 | INF | RELA, RAF1, RAC1, BCL2L11, CHUK, UBC | | 42 | fibroblast growth factor receptor signaling pathway | GO:008543 | INF | RAF1, CHUK, UBC, BAD, CDKN1B, ITPR1 | | 43 | positive regulation of cell proliferation | GO:008284 | INF | CNTF, VIP, VEGFA, VEGFC, MYC, LIF | | 44 | leukocyte migration | GO:050900 | INF | SELL, SELP, SELPLG, BSG, LCK, ATP1B1 | | 45 | inflammatory response | GO:006954 | INF | PIK3CG, RELA, CNR2, SELE, SELP, RAC1 | | 46 | cell-cell signaling | GO:007267 | INF | AVP, ITGB2, ISG15, INS, FGF13, FGF4 | | 47 | platelet degranulation | GO:002576 | INF | VWF, SELP, SERPINA1, SERPINE1, VEGFA, VEGFB | | 48 | transmembrane transport | GO:055085 | INF | GCK, RAE1, AVP, ATP6V0D1, ATP1A2, ATP7A | | 49 | positive regulation of transcription from RNA polymerase II promoter | GO:045944 | INF | KLF4, RELA, SERPINE1, VEGFA, MYC, LIF | | 50 | cellular response to mechanical stimulus | GO:071260 | INF | BNIP3, BAD, BAK1, CD40, , IL18 |
Molecular functions related to ischemia according to GeneDecks: (show all 12)
| id | Name | GO ID | Score | Top Affiliating Genes | | 1 | ATP binding | GO:005524 | INF | PIK3C2A, PIK3CG, SGK1, PC, GCK, NAIP | | 2 | protein binding | GO:005515 | INF | PIK3CG, , COG2, NDFIP1, PDE4A, RELA | | 3 | protein heterodimerization activity | GO:046982 | INF | VEGFA, VEGFB, BNIP3, MYC, RAF1, PANX2 | | 4 | receptor binding | GO:005102 | 17.4 | REN, GCG, SELPLG, SERPINE1, LPL, VCP | | 5 | heparin binding | GO:008201 | 14.6 | VTN, SELL, SELP, SERPINC1, VEGFA, VEGFB | | 6 | protein kinase activity | GO:004672 | 13.7 | PIK3CG, RAF1, CHUK, AVP, JAK2, CDK5 | | 7 | growth factor activity | GO:008083 | 13.6 | CNTF, KITLG, VEGFA, VEGFB, VEGFC, BMP7 | | 8 | hormone activity | GO:005179 | 11.6 | RETN, GCG, VIP, UTS2, UTS2D, LEP | | 9 | enzyme binding | GO:019899 | INF | VIMP, VHL, RAC1, BLZF1, BCHE, UBE2I | | 10 | protein homodimerization activity | GO:042803 | INF | VWF, VEGFA, VEGFB, BNIP3, RABEP1, PARK7 | | 11 | protein kinase binding | GO:019901 | INF | RELA, VIM, PARK2, BCL2L1, LCK, BAD | | 12 | identical protein binding | GO:042802 | INF | RELA, PCNA, VIM, VCP, BNIP3, RAF1 |
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