MCID: ISC004
MIFTS: 64

Ischemia malady

Summaries for Ischemia

About this section
Sources:
63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 In medicine, ischemia, also spelled as ischaemia or ischæmia, (/ɪˈskiːmɪə/;[a]) is a restriction... more...

MalaCards: Ischemia is related to transient cerebral ischemia and spinal cord ischemia. An important gene associated with Ischemia is ADORA3 (adenosine A3 receptor), and among its related pathways are Circadian entrainment and Amino acid and oligopeptide SLC transporters. The compounds glutamate and superoxide have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and heart, and related mouse phenotypes are homeostasis/metabolism and behavior/neurological.

Aliases & Classifications for Ischemia

About this section
Sources:
8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
See all sources

Aliases & Descriptions:

ischemia 8 44 60


External Ids:

Disease Ontology8 DOID:326
NCIt39 C34738
SNOMED-CT56 52674009
MeSH34 D007511

Related Diseases for Ischemia

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Ischemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 467)
idRelated DiseaseScoreTop Affiliating Genes
1transient cerebral ischemia31.6HSPA4, PLA2G2A, ADORA1
2spinal cord ischemia31.6PLA2G2A
3hepatitis31.0XDH
4myocardial infarction30.9NOS3
5hypertension30.8NOS3
6coronary artery disease30.7HSPA4, PLA2G2A, NOS3, ADORA1, ADORA2A
7diabetes mellitus30.5HSPA4, SOD1, NOS3
8vascular disease30.4SOD1, CTSL, XDH, NOS3
9ischemic heart disease30.3SOD1, PRKAA2, PLA2G2A, NOS3, ADORA1
10atherosclerosis30.3HSPA4, SOD1, CTSL, PRKAA2, XDH, PLA2G2A
11type 2 diabetes mellitus30.3HSPA4, SOD1, PRKAA2, NOS3, ADORA1
12brain ischemia30.3HSPA4, NOS3, ADORA1, ADORA3
13pancreatitis30.2SOD1, PLA2G2A
14alzheimer's disease30.2SOD1, CTSL, PLA2G2A, SLC1A2, SLC1A3, NOS3
15glaucoma30.1ADORA3, ADORA1
16dementia30.1HSPA4, SLC1A2, SLC1A3
17migraine30.1SLC1A3
18meningioma29.9CTSL
19cadasil29.8HSPA4, PLA2G2A, SLC1A2, SLC1A3, NOS3, ADORA1
20asthma29.8HSPA4, XDH, PLA2G2A, ADORA1, ADORA3, ADORA2A
21breast cancer29.8HSPA4, CTSL, PRKAA2, PRKCE, XDH, PLA2G2A
22essential hypertension29.8SOD1, XDH, NOS3, ADORA2A
23colorectal cancer29.8PLA2G2A, XDH, CTSL
24pneumonia29.8HSPA4, XDH, ADORA2A
25schizophrenia29.6HSPA4, XDH, PLA2G2A, SLC1A2, SLC1A1, SLC1A3
26melanoma29.6HSPA4, CTSL, PRKCE, XDH, PLA2G2A, ADORA3
27rheumatoid arthritis29.6ADORA2A, ADORA3, ADORA1, PLA2G2A, CTSL
28motor neuron disease29.6HSPA4, SOD1, SLC1A2, SLC1A3
29leukemia29.6HSPA4, CTSL, PLA2G2A, ADORA3
30pre-eclampsia29.6NOS3, PLA2G2A, XDH, SOD1
31arthritis29.6ADORA3, PLA2G2A, CTSL
32multiple sclerosis29.6ADORA1, XDH
33malaria29.6XDH, HSPA4
34huntington's disease29.6ADORA2A, SLC1A2
35hepatopulmonary syndrome29.5NOS3
36cerebritis11.2
37critical limb ischemia11.1
38neuronitis11.0
39retinal ischemia10.9
40retinitis10.9
41cerebral artery occlusion10.6
42aortic aneurysm10.5
43brain edema10.5
44myocardial stunning10.4
45hyperglycemia10.4
46abdominal aortic aneurysm10.4
47carotid artery occlusion10.4
48acute myocardial infarction10.4
49paraplegia10.3
50angina pectoris10.3

Graphical network of the top 20 diseases related to Ischemia:



Diseases related to ischemia

Clinical Features for Ischemia

About this section

Drugs & Therapeutics for Ischemia

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Ischemia

Drug clinical trials:

Search ClinicalTrials for Ischemia

Search NIH Clinical Center for Ischemia

Search CenterWatch for Ischemia

Genetic Tests for Ischemia

About this section

Anatomical Context for Ischemia

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Ischemia:

32
Brain, Spinal cord, Heart, Endothelial, Liver, Kidney, Bone, Lung, Bone marrow, Skeletal muscle, Cortex, Colon, Testes, Skin, Monocytes, Small intestine, Retina, T cells, Cardiac myocytes, Olfactory bulb, Pituitary, B cells, Breast, Eye, Pancreas, Prostate, Smooth muscle, Testis, Prefrontal cortex, Placenta, Spleen, Thyroid, Pancreatic islet, Lymph node, Amygdala, Caudate nucleus, Ovary, Globus pallidus, Fetal brain, Myeloid, Cerebellum

Animal Models for Ischemia or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Ischemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537613.0SLC1A7, XDH, PRKCE, PRKAA2, CTSL, SOD1
2MP:000538612.9ADORA2A, HSPA4, SOD1, CTSL, PRKAA2, PRKCE
3MP:000363112.4HSPA4, SOD1, CTSL, PRKAA2, SLC1A2, SLC1A1
4MP:000538412.2SOD1, CTSL, PRKAA2, PRKCE, XDH, SLC1A2
5MP:000539111.8SOD1, CTSL, SLC1A1, SLC1A3, NOS3, ADK
6MP:000536711.4CTSL, PRKAA2, XDH, SLC1A1, NOS3, ADORA1

Publications for Ischemia

About this section
Sources:
50PubMed
See all sources

Articles related to Ischemia:

(show top 50)    (show all 5367)
idTitleAuthorsYear
1
Effects of the PPAR-I+ agonist fenofibrate on acute and short-term consequences of brain ischemia. (24398933)
2014
2
Bradykinin preconditioning affects the number of degenerated neurons and the level of antioxidant enzymes in spinal cord ischemia in rabbits. (23981244)
2013
3
Serum lactate and phosphate as biomarkers of intestinal ischemia in a Ugandan tertiary hospital: a cross-sectional study. (24304560)
2013
4
The Effects of Luteolin on the Intestinal Ischemia/Reperfusion Injury in Mice. (24354416)
2013
5
Worse limb prognosis for indirect versus direct endovascular revascularization only in patients with critical limb ischemia complicated with wound infection and diabetes mellitus. (24034905)
2013
6
PPAR-I^ activator induces neuroprotection in hypercholesterolemic rats subjected to global cerebral ischemia/reperfusion injury: In vivo and in vitro inhibition of oxidative stress. (24373843)
2013
7
Pedal bypass with deep venous arterialization: the therapeutic option in critical limb ischemia and unreconstructable distal arteries. (22008976)
2011
8
Effect of angiotensin II type 2 receptor deletion in hematopoietic cells on brain ischemia-reperfusion injury. (21768524)
2011
9
Clinical significance of anti-annexin V antibody in acute cerebral ischemia. (21450308)
2011
10
Low-dose cardiotonic steroids increase sodium-potassium ATPase activity that protects hippocampal slice cultures from experimental ischemia. (19822191)
2010
11
Cilostazol may improve outcome in critical limb ischemia. (19935589)
2009
12
Region-specific sensitivity of the spinal cord to ischemia/reperfusion: the dynamic of changes in catalytic NOS activity. (19340549)
2009
13
Changes in tissue factor and the effects of tissue factor pathway inhibitor on transient focal cerebral ischemia in rats. (18067952)
2008
14
A case control study of statin and magnesium administration in patients after aneurysmal subarachnoid hemorrhage: incidence of delayed cerebral ischemia and mortality. (18691455)
2008
15
Renal urokinase-type plasminogen activator (uPA) receptor but not uPA deficiency strongly attenuates ischemia reperfusion injury and acute kidney allograft rejection. (18606671)
2008
16
Apoptosis-inducing factor is a major contributor to neuronal loss induced by neonatal cerebral hypoxia-ischemia. (17039248)
2007
17
Myxedema coma and cardiac ischemia in relation to thyroid hormone replacement therapy in a 38-year-old Japanese woman. (18201588)
2007
18
The importance of ceruloplasmin oxidase activity in patients with chronic lower limb atherosclerotic ischemia. (18091701)
2007
19
Intrinsic and extrinsic erythropoietin enhances neuroprotection against ischemia and reperfusion injury in vitro. (16417583)
2006
20
Degradation of spectrin via calpains in the ventral horn after transient spinal cord ischemia in rabbits. (16847592)
2006
21
Retinal ischemia with neovascularization in cisplatin related retinal toxicity. (16387001)
2006
22
Protective roles of thioredoxin, a redox-regulating protein, in renal ischemia/reperfusion injury. (12969145)
2003
23
Potential beneficial as well as detrimental effects of chronic treatment with lisinopril and (or) spironolactone on isolated hearts following low-flow ischemia in normal and infarcted rats. (14614522)
2003
24
Ischemia-induced dephosphorylation of cardiomyocyte connexin-43 is reduced by okadaic acid and calyculin A but not fostriecin. (12619875)
2003
25
The effects of FK506 on neurologic and histopathologic outcome after transient spinal cord ischemia induced by aortic cross-clamping in rats. (11323353)
2001
26
Induction of apoptosis and Fas receptor/Fas ligand expression by ischemia/reperfusion in cardiac myocytes requires serine 727 of the STAT-1 transcription factor but not tyrosine 701. (11309387)
2001
27
Effective reduction of neuronal death by inhibiting gap junctional intercellular communication in a rodent model of global transient cerebral ischemia. (11476596)
2001
28
Electrochemical monitoring of superoxide anion production and cerebral blood flow: effect of interleukin-1 beta pretreatment in a model of focal ischemia and reperfusion. (10861792)
2000
29
Combined choroidal and retinal ischemia during interferon therapy: indocyanine green angiographic and microperimetric findings. (10766150)
2000
30
Inhibition of the sodium-hydrogen exchanger with cariporide to prevent myocardial infarction in high-risk ischemic situations. Main results of the GUARDIAN trial. Guard during ischemia against necrosis (GUARDIAN) Investigators. (11120691)
2000
31
Expression of cell death-associated phospho-c-Jun and p53-activated gene 608 in hippocampal CA1 neurons following global ischemia. (10581407)
1999
32
Interaction between neutrophils and endothelial cells following ischemia/reperfusion]. (10412150)
1999
33
Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia. (9861045)
1998
34
Consecutive evaluation of nitric oxide production after transient cerebral ischemia in the rat hippocampus using in vivo brain microdialysis. (9488173)
1998
35
Attenuation of myocardial ischemia with repeated exercise in subjects with chronic stable angina: relation to myocardial contractility, intensity of exercise and the adenosine triphosphate-sensitive potassium channel. (9822094)
1998
36
Isoform-specific redistribution of calcineurin A alpha and A beta in the hippocampal CA1 region of gerbils after transient ischemia. (9489752)
1998
37
Digital ischemia and gangrene due to red blood cell aggregation induced by acquired dysfibrinogenemia. (9423724)
1997
38
Amelioration of ischemia-reperfusion injury by human thioredoxin in rabbit lung. (9011676)
1997
39
Ischemia and reperfusion reduce the endogenous basic fibroblast growth factor in rat skeletal muscles: an immunohistochemical study. (17177736)
1996
40
Effect of nitric oxide synthase inhibition on blood flow after retinal ischemia in cats. (7591629)
1995
41
Survival of parvalbumin-immunoreactive neurons in the gerbil hippocampus following transient forebrain ischemia does not depend on HSP-70 protein induction. (8548318)
1995
42
Effect of the combination of human thioredoxin and L-cysteine on ischemia-reperfusion injury in isolated rat lungs. (8542921)
1995
43
Reduced adipose tissue lipoprotein lipase responses, postprandial lipemia, and low high-density lipoprotein-2 subspecies levels in older athletes with silent myocardial ischemia. (8121301)
1994
44
N-methyl-D-aspartate receptor-mediated, prolonged afterdischarges of CA1 pyramidal cells following transient cerebral ischemia in the rat hippocampus in vivo. (7529643)
1994
45
Use of aromatic hydroxylation of phenylalanine to measure production of hydroxyl radicals after myocardial ischemia in vivo. Direct evidence for a pathogenetic role of the hydroxyl radical in myocardial stunning. (8394226)
1993
46
Pharmacology of the endothelium in ischemia-reperfusion and circulatory shock. (8494355)
1993
47
Reduction of HSP70 and HSC70 heat shock mRNA induction by pentobarbital after transient global ischemia in gerbil brain. (8515271)
1993
48
Transient global amnesia followed by vertebrobasilar ischemia in a case of dolichoectatic basilar artery. (2085087)
1990
49
Altered protein kinase C activity in different subfields of hippocampus following cerebral ischemia. (2370943)
1990
50
Spinal cord ischemia following surgery for aortoiliac occlusive disease. (6502845)
1984

Genetic Variations for Ischemia

About this section

Expression for genes affiliated with Ischemia

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Ischemia

Search GEO for disease gene expression data for Ischemia.

Pathways for genes affiliated with Ischemia

About this section
Sources:
29KEGG, 53Reactome, 4Cell Signaling Technology, 51QIAGEN, 12EMD Millipore, 37NCBI BioSystems Database, 49PharmGKB
See all sources

Pathways related to Ischemia according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.5ADORA1, SLC1A3, SLC1A6, SLC1A1, SLC1A2, SLC1A7
2
Hide members
11.3SLC1A3, SLC1A6, SLC1A1, SLC1A2, SLC1A7
3
Hide members
11.3SLC1A3, SLC1A6, SLC1A1, SLC1A2, SLC1A7
4
Hide members
11.3SLC1A3, SLC1A6, SLC1A1, SLC1A2, SLC1A7
511.2SOD1, SLC1A2, SLC1A1, SLC1A3
6
Hide members
11.2SOD1, SLC1A2, SLC1A1, SLC1A3
711.0SLC1A2, SLC1A1, SLC1A3
8
Hide members
11.0ADORA1, ADORA3, ADORA2A
911.0SLC1A1, SLC1A2, SOD1
10
Signal transduction IP3 signaling
Hide members
11.0ADORA2A, ADORA3, PRKCE
11
Development A3 receptor signaling
Hide members
11.0ADORA3, ADORA1, PRKCE
12
Development A2B receptor- action via G-protein alpha s
Hide members
11.0PRKCE, NOS3, ADORA2A
13
Hide members
11.0NOS3, XDH, SOD1
14
Hide members
11.0SLC1A7, SLC1A1, SLC1A6
15
Hide members
11.0SLC1A7, SLC1A1, SLC1A6
16
CFTR folding and maturation (norm and CF)
11.0NOS3, SOD1, HSPA4
17
Hide members
10.8SLC1A3, SLC1A2

Compounds for genes affiliated with Ischemia

About this section
Sources:
44Novoseek, 24HMDB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience
See all sources

Compounds related to Ischemia according to GeneCards/GeneDecks:

(show top 50)    (show all 200)
idCompoundScoreTop Affiliating Genes
1glutamate4413.4HSPA4, ADORA3, ADORA1, NOS3, SLC1A3, SLC1A6
2superoxide44 2413.6SLC1A2, PLA2G2A, XDH, PRKAA2, CTSL, SOD1
3adenylate4412.5PLA2G2A, ADORA3, HSPA4, SLC1A2, SLC1A3, ADK
4nitric oxide44 11 2414.5PRKAA2, ADORA2A, XDH, SOD1, ADORA3, SLC1A2
5alanine4412.4ADORA1, PRKAA2, SOD1, PLA2G2A, SLC1A2, CTSL
6nmda44 2813.3ADK, HSPA4, SLC1A7, SLC1A2, SLC1A1, SLC1A3
7aspartate4412.3HSPA4, SLC1A3, SLC1A1, CTSL, ADORA2A, ADORA1
8xanthine44 2413.1SOD1, ADORA1, XDH, NOS3, ADK, ADORA2A
9kainate44 2813.1HSPA4, ADK, ADORA2A, ADORA1, SLC1A3, SLC1A1
10serine4411.9SLC1A2, PLA2G2A, SLC1A3, PRKCE, PRKAA2, CTSL
11tfb-tboa5911.8SLC1A3, SLC1A7, SLC1A1, SLC1A2, SLC1A6
12dl-tboa59 2812.8SLC1A6, SLC1A3, SLC1A1, SLC1A7, SLC1A2
13[3h]d-aspartic acid2811.8SLC1A7, SLC1A3, SLC1A6, SLC1A1, SLC1A2
14way 2136135911.8SLC1A3, SLC1A6, SLC1A1, SLC1A2, SLC1A7
15dihydrokainic acid5911.8SLC1A7, SLC1A2, SLC1A1, SLC1A6, SLC1A3
16l-trans-2,4-pdc5911.8SLC1A3, SLC1A7, SLC1A2, SLC1A1, SLC1A6
17[3h]l-aspartic acid2811.8SLC1A3, SLC1A6, SLC1A1, SLC1A2, SLC1A7
18[3h]etb-tboa2811.8SLC1A7, SLC1A1, SLC1A2, SLC1A3, SLC1A6
19theophylline44 28 11 2414.7ADORA1, XDH, ADK, ADORA2A, ADORA3
20n(6)-cyclohexyladenosine44 2812.6ADORA2A, ADORA3, ADORA1, ADK
21adenosine28 11 2413.6ADORA2A, ADORA3, ADORA1, ADK
22peneca2811.4ADORA3, ADORA1, ADORA2A
23mrs51512811.4ADORA2A, ADORA1, ADORA3
24psb-102811.4ADORA1, ADORA3, ADORA2A
25psb-112811.4ADORA3, ADORA2A, ADORA1
265-diethoxyphosphoryl-5-methyl-1-pyrroline n-oxide4411.4NOS3, XDH, SOD1
27dihydrokainate44 2812.4SLC1A3, SLC1A1, SLC1A2
28apadenoson2811.4ADORA2A, ADORA3, ADORA1
29(r,s)-phpneca2811.4ADORA2A, ADORA3, ADORA1
30cvt-68832811.3ADORA3, ADORA2A, ADORA1
31mrs15232811.3ADORA1, ADORA3, ADORA2A
32xac2811.3ADORA1, ADORA3, ADORA2A
33preladenant2811.3ADORA2A, ADORA3, ADORA1
34ib-meca28 5912.3ADORA2A, ADORA3, ADORA1
35bay60-65832811.3ADORA2A, ADORA3, ADORA1
368-cyclopentyltheophylline4411.3ADORA2A, ADORA1, ADK
37biib0142811.3ADORA1, ADORA3, ADORA2A
38neca2811.3ADORA2A, ADORA3, ADORA1
392-hexynyl-neca2811.3ADORA2A, ADORA3, ADORA1
40msx-22811.2ADORA2A, ADORA3, ADORA1
41st-15352811.2ADORA2A, ADORA3, ADORA1
428-phenyltheophylline4411.2ADORA2A, ADORA1, ADK
438-(p-sulfophenyl)theophylline4411.2ADORA2A, ADORA3, ADORA1
44atl8022811.2ADORA2A, ADORA3, ADORA1
45cyclopentyladenosine2811.1ADORA2A, ADORA3, ADORA1
46mrs35582811.1ADORA2A, ADORA3, ADORA1
47(r)-pia2811.0ADORA1, ADORA3, ADORA2A
48mrs17542811.0ADORA2A, ADORA3, ADORA1
49slv3202810.9ADORA2A, ADORA3, ADORA1
50kf267772810.7ADORA2A, ADORA3, ADORA1

GO Terms for genes affiliated with Ischemia

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Ischemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588612.5SOD1, PRKCE, SLC1A7, SLC1A2, SLC1A1, SLC1A6
2membraneGO:01602011.5YRDC, SLC1A2, SLC1A1, SLC1A6, SLC1A3, ADORA2A
3axolemmaGO:03067311.1ADORA2A, ADORA1, SLC1A2
4neuronal cell bodyGO:04302510.9SOD1, SLC1A3, ADORA1, ADORA2A
5presynaptic active zoneGO:04878610.8ADORA2A, ADORA1
6asymmetric synapseGO:03227910.7ADORA2A, ADORA1

Biological processes related to Ischemia according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1ion transportGO:00681111.6SLC1A7, SLC1A2, SLC1A1, SLC1A6, SLC1A3
2transmembrane transportGO:05508511.2SLC1A7, SLC1A2, SLC1A1, SLC1A6, SLC1A3
3D-aspartate importGO:07077911.2SLC1A3, SLC1A1, SLC1A2
4L-glutamate importGO:05193811.2SLC1A3, SLC1A1, SLC1A2
5response to woundingGO:00961111.2ADORA3, SLC1A3, SLC1A2
6positive regulation of mucus secretionGO:07025711.0ADORA3, PRKCE
7relaxation of vascular smooth muscleGO:06008710.9SOD1, ADORA1
8L-glutamate transportGO:01581310.9SLC1A6, SLC1A7
9response to drugGO:04249310.9ADORA2A, SLC1A3, SLC1A2, SOD1
10positive regulation of synaptic transmission, GABAergicGO:03223010.8ADORA2A, PRKCE
11regulation of mitochondrial membrane potentialGO:05188110.8ADORA2A, SOD1

Molecular functions related to Ischemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sodium:dicarboxylate symporter activityGO:01715311.5SLC1A3, SLC1A6, SLC1A1, SLC1A2, SLC1A7
2L-glutamate transmembrane transporter activityGO:00531311.4SLC1A7, SLC1A2, SLC1A1, SLC1A6, SLC1A3
3G-protein coupled adenosine receptor activityGO:00160911.0ADORA2A, ADORA3, ADORA1
4actin monomer bindingGO:00378510.8NOS3, PRKCE
5glutamate:sodium symporter activityGO:01550110.7SLC1A2, SLC1A1
6glutamate bindingGO:01659510.5SLC1A3, SLC1A1

Products for genes affiliated with Ischemia

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Ischemia

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet