MCID: ISC004
MIFTS: 63

Ischemia malady

Cardiovascular diseases category

Summaries for Ischemia

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9Disease Ontology, 66Wikipedia, 34MalaCards
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Wikipedia:66 In medicine, ischemia, also spelled as ischaemia or isch more...

MalaCards: Ischemia is related to brain ischemia and transient cerebral ischemia. An important gene associated with Ischemia is ADORA3 (adenosine A3 receptor), and among its related pathways are Neurotransmitter uptake and Metabolism In Glial Cells and Glutamic acid signaling. The compounds psb-11 and peneca have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and heart, and related mouse phenotypes are vision/eye and renal/urinary system.

Disease Ontology:9 A vascular disease that is characterized by a restriction in blood supply to tissues.

Aliases & Classifications for Ischemia

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9Disease Ontology, 46Novoseek, 63UMLS, 41NCIt, 59SNOMED-CT, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

ischemia 9 46 63


External Ids:

Disease Ontology9 DOID:326
NCIt41 C34738
SNOMED-CT59 52674009
MeSH36 D007511

Related Diseases for Ischemia

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Ischemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 504)
idRelated DiseaseScoreTop Affiliating Genes
1brain ischemia31.8HSPA4, ADORA3, ADORA1, NOS3
2transient cerebral ischemia31.7HSPA4, ADORA1, PLA2G2A
3coronary artery disease30.9XDH, HSPA4, PLA2G2A, NOS3
4type 2 diabetes mellitus30.4HSPA4, SOD1, ADORA1, PRKAA2, NOS3
5vascular disease30.4XDH, SOD1, NOS3, CTSL
6atherosclerosis30.4XDH, HSPA4, SOD1, PRKAA2, PLA2G2A, NOS3
7hypercholesterolemia30.3XDH, PLA2G2A, NOS3
8dementia30.2SLC1A2, SLC1A3, HSPA4
9alzheimer's disease30.2SOD1, ADORA1, ADORA2A, PLA2G2A, NOS3, CTSL
10sepsis30.2NOS3, PLA2G2A, ADORA2A, XDH
11insulin resistance30.1ADORA1, PRKAA2, PLA2G2A, NOS3
12cerebrovascular disease30.0HSPA4, ADORA3, ADORA1, ADORA2A, PLA2G2A, NOS3
13acute chest syndrome30.0NOS3, PLA2G2A
14essential hypertension29.9NOS3, ADORA2A, SOD1, XDH
15pneumonia29.9ADORA2A, HSPA4, XDH
16asthma29.9XDH, HSPA4, ADORA3, ADORA1, ADORA2A, PLA2G2A
17breast cancer29.9XDH, HSPA4, ADORA3, PRKAA2, PRKCE, PLA2G2A
18huntington's disease29.7HSPA4, SOD1, ADORA2A, SLC1A2
19septic shock29.7NOS3, PLA2G2A, XDH
20pre-eclampsia29.7XDH, SOD1, PLA2G2A, NOS3
21rheumatoid arthritis29.7ADORA3, ADORA1, ADORA2A, PLA2G2A, CTSL
22schizophrenia29.7XDH, HSPA4, ADORA2A, PLA2G2A, SLC1A1, SLC1A3
23melanoma29.6XDH, HSPA4, ADORA3, ADORA2A, PRKCE, PLA2G2A
24cerebritis11.3
25limb ischemia11.1
26critical limb ischemia11.1
27neuronitis11.0
28retinitis11.0
29retinal ischemia10.9
30hypoxia10.9
31endotheliitis10.8
32cerebral hypoxia10.8
33aneurysm10.7
34hepatitis10.7
35artery disease10.6
36hypertension10.6
37aortic aneurysm10.6
38myocardial infarction10.6
39cerebral artery occlusion10.5
40brain edema10.5
41brain injury10.5
42myocardial stunning10.5
43hyperglycemia10.4
44abdominal aortic aneurysm10.4
45carotid artery occlusion10.4
46diabetes mellitus10.4
47paraplegia10.4
48angina pectoris10.3
49blindness10.3
50peripheral artery disease10.3

Graphical network of the top 20 diseases related to Ischemia:



Diseases related to ischemia

Symptoms for Ischemia

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Drugs & Therapeutics for Ischemia

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Ischemia

Drug clinical trials:

Search ClinicalTrials for Ischemia

Search NIH Clinical Center for Ischemia

Search CenterWatch for Ischemia

Genetic Tests for Ischemia

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Anatomical Context for Ischemia

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34MalaCards
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MalaCards organs/tissues related to Ischemia:

34
Brain, Spinal cord, Heart, Endothelial, Liver, Kidney, Bone, Lung, Bone marrow, Skeletal muscle, Cortex, Colon, Testes, Skin, Monocytes, Small intestine, Retina, T cells, Cardiac myocytes, Olfactory bulb, Pituitary, B cells, Breast, Eye, Pancreas, Prostate, Smooth muscle, Testis, Prefrontal cortex, Placenta, Spleen, Thyroid, Pancreatic islet, Lymph node, Amygdala, Caudate nucleus, Ovary, Globus pallidus, Fetal brain, Myeloid, Cerebellum

Animal Models for Ischemia or affiliated genes

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38MGI
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Publications for Ischemia

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53PubMed
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Articles related to Ischemia:

(show top 50)    (show all 5326)
idTitleAuthorsYear
1
Comparison of graft patency, limb salvage, and antithrombotic therapy between prosthetic and autogenous below-knee bypass for critical limb ischemia. (24011814)
2013
2
Verapamil augments the neuroprotectant action of berberine in rat model of transient global cerebral ischemia. (24177287)
2013
3
Effect of cation type and concentration of nitrates on neurological disorders during experimental cerebral ischemia. (24288757)
2013
4
Arteriographic findings in diabetic and non-diabetic with critical limb ischemia. (24211015)
2013
5
The relationship between ischemia modified albumin and oxidative stress parameters in patients with cardiac syndrome X. (24409667)
2013
6
Neuroprotective effect of melatonin against ischemia is partially mediated by alpha-7 nicotinic receptor modulation and HO-1 overexpression. (24350834)
2013
7
Bifurcation stenting after failed angioplasty of infrapopliteal arteries in critical limb ischemia: techniques and short-term follow-up. (23404942)
2013
8
The vulnerability of nitrergic neurons to transient spinal cord ischemia: a quantitative immunohistochemical and histochemical study. (22228218)
2012
9
Acute mesenteric ischemia and duodenal ulcer perforation: a unique double pathology. (23110681)
2012
10
Spinal cord ischemia occurring in association with induced hypotension for colonic surgery. (22075019)
2012
11
Human umbilical cord blood cells protect oligodendrocytes from brain ischemia through Akt signal transduction. (22158864)
2012
12
Plasma proteomic analysis of the critical limb ischemia markers in diabetic patients with hemodialysis. (21468429)
2011
13
Endovascular management of patients with critical limb ischemia. (21211929)
2011
14
Ischemia induced peroxynitrite dependent modifications of cardiomyocyte MLC1 increases its degradation by MMP-2 leading to contractile dysfunction. (20518849)
2011
15
Hypoxia-ischemia induces hypo-phosphorylation of collapsin response mediator protein 2 in a neonatal rat model of periventricular leukomalacia. (21333637)
2011
16
Transplantation of human mesenchymal stem cells promotes functional improvement and increased expression of neurotrophic factors in a rat focal cerebral ischemia model. (19885863)
2010
17
Transient middle cerebral artery occlusion in rats as an experimental model of brain ischemia. (20877953)
2010
18
Understanding objective performance goals for critical limb ischemia trials. (20826289)
2010
19
Lack of adrenomedullin, but not complement factor H, results in larger infarct size and more extensive brain damage in a focal ischemia model. (20854881)
2010
20
Antioxidant properties of alpha-lipoic acid: effects on red blood membrane permeability and adaptation of isolated rat heart to reversible ischemia. (18839280)
2009
21
Fate and manipulations of endogenous neural stem cells following brain ischemia. (19653861)
2009
22
Severe acute ocular ischemia associated with spontaneous internal carotid artery dissection. (17999033)
2008
23
Individual treatment strategies for patients suffering from critical limb ischemia are mandatory. (17390300)
2007
24
Subintimal angioplasty as the first-choice revascularization technique for infrainguinal arterial occlusions in patients with critical limb ischemia. (17980800)
2007
25
Peroxisome proliferator-activated receptors ligands and ischemia-reperfusion injury. (17394034)
2007
26
Current opinions regarding the spinal cord ischemia syndrome. (18386602)
2006
27
CD40/CD40 ligand signaling in mouse cerebral microvasculature after focal ischemia/reperfusion. (15795333)
2005
28
Neuroprotection afforded by prior citicoline administration in experimental brain ischemia: effects on glutamate transport. (15686962)
2005
29
Inflammation and ischemia: macrophages activated by fibronectin fragments enhance the survival of injured cardiac myocytes. (15169973)
2004
30
Diffusion-weighted MR imaging in acute spinal cord ischemia. (15022011)
2004
31
Recombinant t-PA in myocardial ischemia after switch operation. (15054563)
2004
32
Overexpression of SSAT in kidney cells recapitulates various phenotypic aspects of kidney ischemia-reperfusion injury. (15213272)
2004
33
The temporal profile of the reaction of microglia, astrocytes, and macrophages in the delayed onset paraplegia after transient spinal cord ischemia in rabbits. (12761011)
2003
34
Endothelial nitric oxide synthase expression in ischemia-reperfusion injury after living related-donor renal transplantation. (12478411)
2002
35
In vivo models of myocardial ischemia and reperfusion injury: application to drug discovery and evaluation. (11150743)
2000
36
Effect of dopamine blockers on cerebral ischemia-induced hyperactivity in gerbils. (10336152)
1999
37
Prevention of both T2- and diffusion-weighted increases in image intensity during cerebral hypoxia-ischemia in infant rats pretreated with dexamethasone. (10204774)
1999
38
BDNF diminishes caspase-2 but not c-Jun immunoreactivity of neurons in retinal ganglion cell layer after transient ischemia. (10549664)
1999
39
Delayed recovery of auditory cortical evoked potentials is correlated with cortical neuronal death after transient cerebral ischemia in awake gerbils. (9739151)
1998
40
Cytokines and adhesion molecules in elective and accidental trauma-related ischemia/reperfusion. (9603092)
1998
41
Blood-retinal barrier breakdown following experimental retinal ischemia and reperfusion. (8654497)
1995
42
The effects of naloxone on retinal ischemia in rats. (8083567)
1994
43
Human recombinant extracellular-superoxide dismutase type C improves cardioplegic protection against ischemia/reperfusion injury in isolated rat heart. (7528849)
1994
44
Cerebral ischemia in a patient with protein S deficiency and carotid stenosis. (8056555)
1994
45
Retinal ischemia and cell proliferation in the rat: the role of soluble mitogens. (2338257)
1990
46
Lack of conversion of xanthine dehydrogenase to xanthine oxidase during warm renal ischemia. (2253787)
1990
47
Effect of peroxide, sodium, and calcium on brain mitochondrial respiration in vitro: potential role in cerebral ischemia and reperfusion. (2313294)
1990
48
Neurological outcome correlated with spinal evoked potentials in a spinal cord ischemia model. (6707748)
1984
49
Lack of effect of ischemia and dipyridamole on prostacyclin production in arteriosclerosis obliterans. (7041195)
1981
50
Management of transient cerebral ischemia. (573393)
1979

Variations for Ischemia

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Expression for genes affiliated with Ischemia

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ischemia

Search GEO for disease gene expression data for Ischemia.

Pathways for genes affiliated with Ischemia

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Sources:
51PathCards, 56Reactome, 39NCBI BioSystems Database, 13EMD Millipore, 55R&D Systems, 61Thomson Reuters, 52PharmGKB, 31KEGG, 54QIAGEN, 5Cell Signaling Technology
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Pathways related to Ischemia according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.2SLC1A2, SLC1A3
2
Show member pathways
10.1SLC1A2, SLC1A3, SLC1A1
3
Show member pathways
10.1ADORA3, ADORA1, ADORA2A
410.0SOD1, SLC1A1, SLC1A2
5
Show member pathways
Development A1 receptor signaling61
G protein signaling G Protein alpha q signaling cascades61
10.0PRKCE, ADORA1, ADORA3
6
Show member pathways
9.9XDH, SOD1, NOS3
7
Show member pathways
Development A2B receptor action via G protein alpha s61
9.9NOS3, PRKCE, ADORA2A
8
Show member pathways
9.9SLC1A6, SLC1A7, SLC1A1
9
Show member pathways
Amyotrophic lateral sclerosis (ALS)39
9.9SOD1, SLC1A1, SLC1A3, SLC1A2
109.9SOD1, SLC1A1, SLC1A3, SLC1A2
11
Show member pathways
9.9HSPA4, SOD1, NOS3
12
Show member pathways
Development EDNRB signaling61
Development ACM2 and ACM4 activation of ERK61
Cell adhesion Integrin inside out signaling61
Development G Proteins mediated regulation MARK ERK signaling61
Signal transduction IP3 signaling61
Development Angiotensin signaling via PYK261
Development EPO induced MAPK pathway61
9.8NOS3, PRKCE, ADORA2A, ADORA3
13
Show member pathways
9.6NOS3, PLA2G2A, PRKCE, PRKAA2, ADORA2A
14
Show member pathways
9.6SLC1A2, SLC1A6, SLC1A3, SLC1A7, SLC1A1
15
Show member pathways
9.6SLC1A1, SLC1A7, SLC1A3, SLC1A6, SLC1A2
16
Show member pathways
9.5SLC1A2, SLC1A6, SLC1A3, SLC1A7, SLC1A1, ADORA1

Compounds for genes affiliated with Ischemia

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Sources:
30IUPHAR, 46Novoseek, 25HMDB, 12DrugBank, 62Tocris Bioscience
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Compounds related to Ischemia according to GeneCards/GeneDecks:

(show top 50)    (show all 221)
idCompoundScoreTop Affiliating Genes
1psb-113010.4ADORA3, ADORA2A, ADORA1
2peneca3010.4ADORA2A, ADORA1, ADORA3
3psb-103010.4ADORA2A, ADORA1, ADORA3
4apadenoson3010.4ADORA2A, ADORA1, ADORA3
5mrs51513010.4ADORA3, ADORA1, ADORA2A
6dihydrokainate46 3011.4SLC1A1, SLC1A3, SLC1A2
7(r,s)-phpneca3010.4ADORA2A, ADORA1, ADORA3
8las380963010.4ADORA1, ADORA2A, ADORA3
9mre 2029f203010.4ADORA2A, ADORA1, ADORA3
10cyclopentyladenosine3010.4ADORA3, ADORA2A, ADORA1
11cvt-68833010.4ADORA3, ADORA1, ADORA2A
12atl8023010.3ADORA3, ADORA1, ADORA2A
13mrs35583010.3ADORA3, ADORA1, ADORA2A
14fk-4533010.3ADORA3, ADORA1, ADORA2A
15n(6)-cyclohexyladenosine46 3011.3ADORA1, ADORA2A, ADK, ADORA3
16xac3010.3ADORA3, ADORA1, ADORA2A
17adenosine30 25 1212.3ADK, ADORA3, ADORA1, ADORA2A
18hemado3010.3ADORA3, ADORA1, ADORA2A
195-diethoxyphosphoryl-5-methyl-1-pyrroline n-oxide4610.3NOS3, SOD1, XDH
20rolofylline3010.3ADORA3, ADORA1, ADORA2A
21neca3010.3ADORA2A, ADORA1, ADORA3
22biib0143010.2ADORA3, ADORA1, ADORA2A
23istradefylline46 3011.2ADORA3, ADORA1, ADORA2A
24binodenoson46 3011.2ADORA3, ADORA1, ADORA2A
25regadenoson46 30 1212.1ADORA3, ADORA1, ADORA2A
26theophylline46 30 25 1213.1ADORA1, ADORA3, XDH, ADK, ADORA2A
27tfb-tboa6210.1SLC1A7, SLC1A6, SLC1A2, SLC1A1, SLC1A3
28[3h]etb-tboa3010.1SLC1A2, SLC1A6, SLC1A3, SLC1A7, SLC1A1
29cgs 216803010.1ADORA3, ADORA1, ADORA2A
30l-trans-2,4-pdc6210.1SLC1A1, SLC1A7, SLC1A3, SLC1A6, SLC1A2
312-hexynyl-neca3010.1ADORA3, ADORA1, ADORA2A
32[3h]d-aspartic acid3010.1SLC1A6, SLC1A1, SLC1A7, SLC1A3, SLC1A2
33[3h]l-aspartic acid3010.1SLC1A2, SLC1A6, SLC1A3, SLC1A7, SLC1A1
34way 2136136210.1SLC1A1, SLC1A7, SLC1A2, SLC1A6, SLC1A3
35dihydrokainic acid6210.0SLC1A1, SLC1A7, SLC1A3, SLC1A2, SLC1A6
36dl-tboa62 3011.0SLC1A1, SLC1A7, SLC1A3, SLC1A6, SLC1A2
37st-15353010.0ADORA3, ADORA1, ADORA2A
38l-glutamic acid30 25 1211.9SLC1A2, SLC1A1, SLC1A3, SLC1A6, SLC1A7
39xanthine46 2510.8XDH, SOD1, NOS3, ADK, ADORA3, ADORA1
40kainate46 3010.8ADORA1, HSPA4, ADK, ADORA2A, SLC1A1, SLC1A3
41msx-2309.8ADORA3, ADORA1, ADORA2A
42aspartate469.5HSPA4, ADORA1, ADORA2A, CTSL, SLC1A1, SLC1A3
43adenylate469.5PRKAA2, PLA2G2A, SLC1A3, ADK, HSPA4, SLC1A2
44nitric oxide46 25 1211.4PRKAA2, NOS3, HSPA4, SLC1A3, SLC1A2, XDH
45oxygen46 2510.4HSPA4, ADORA3, SOD1, SLC1A2, NOS3, PRKAA2
46nmda46 3010.4ADORA1, ADK, HSPA4, PLA2G2A, SLC1A1, SLC1A7
47alanine469.4HSPA4, PRKAA2, ADORA1, SOD1, CTSL, SLC1A1
48superoxide46 2510.2SOD1, ADORA3, PRKAA2, PLA2G2A, SLC1A2, XDH
49serine469.0PRKAA2, ADORA2A, SLC1A2, SLC1A3, CTSL, PLA2G2A
50glutamate468.4SLC1A2, HSPA4, SOD1, ADORA3, ADORA1, ADORA2A

GO Terms for genes affiliated with Ischemia

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17Gene Ontology
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Cellular components related to Ischemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1presynaptic active zoneGO:04878610.2ADORA2A, ADORA1
2axolemmaGO:03067310.2SLC1A2, ADORA2A, ADORA1
3asymmetric synapseGO:0322799.9ADORA2A, ADORA1
4neuronal cell bodyGO:0430259.8SOD1, ADORA1, ADORA2A, SLC1A3
5membraneGO:0160209.5YRDC, ADORA2A, SLC1A1, SLC1A3, SLC1A6, SLC1A2
6plasma membraneGO:0058868.7SOD1, ADORA3, ADORA1, ADORA2A, PRKCE, NOS3

Biological processes related to Ischemia according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of mucus secretionGO:07025710.4ADORA3, PRKCE
2relaxation of vascular smooth muscleGO:06008710.4ADORA1, SOD1
3D-aspartate importGO:07077910.4SLC1A2, SLC1A3, SLC1A1
4L-glutamate importGO:05193810.4SLC1A2, SLC1A3, SLC1A1
5response to woundingGO:00961110.3SLC1A2, SLC1A3, ADORA3
6positive regulation of synaptic transmission, GABAergicGO:03223010.3ADORA2A, PRKCE
7regulation of mitochondrial membrane potentialGO:05188110.2ADORA2A, SOD1
8L-glutamate transportGO:01581310.2SLC1A7, SLC1A6
9negative regulation of blood pressureGO:04577610.1NOS3, ADORA1
10regulation of excitatory postsynaptic membrane potentialGO:06007910.1ADORA2A, ADORA1
11response to drugGO:04249310.0SLC1A2, SLC1A3, ADORA2A, SOD1
12synaptic transmissionGO:00726810.0SLC1A1, SLC1A3, SLC1A6, SLC1A2
13ion transportGO:0068119.9SLC1A1, SLC1A7, SLC1A3, SLC1A6, SLC1A2
14transmembrane transportGO:0550859.8SLC1A1, SLC1A7, SLC1A3, SLC1A6, SLC1A2
15blood coagulationGO:0075969.8SOD1, ADORA2A, PRKCE, NOS3
16signal transductionGO:0071659.4SMOC2, ADORA3, ADORA1, PRKAA2, PRKCE

Molecular functions related to Ischemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutamate:sodium symporter activityGO:01550110.1SLC1A1, SLC1A2
2actin monomer bindingGO:00378510.1NOS3, PRKCE
3G-protein coupled adenosine receptor activityGO:00160910.1ADORA2A, ADORA1, ADORA3
4glutamate bindingGO:0165959.9SLC1A3, SLC1A1
5sodium:dicarboxylate symporter activityGO:0171539.7SLC1A2, SLC1A6, SLC1A3, SLC1A7, SLC1A1
6L-glutamate transmembrane transporter activityGO:0053139.7SLC1A1, SLC1A7, SLC1A3, SLC1A6, SLC1A2

Products for genes affiliated with Ischemia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Ischemia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet