Aliases & Classifications for Ischemia

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Sources:
8Disease Ontology, 44Novoseek, 61UMLS, 33MeSH, 39NCIt, 56SNOMED-CT
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Aliases & Descriptions for Ischemia:

Name: Ischemia 8 44 61


External Ids:

Disease Ontology8 DOID:326
MeSH33 D007511
SNOMED-CT56 52674009
NCIt39 C34738

Summaries for Ischemia

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Wikipedia:64 Ischemia, also spelled as ischaemia or isch more...

MalaCards based summary: Ischemia is related to brain ischemia and transient cerebral ischemia. An important gene associated with Ischemia is ADORA3 (adenosine A3 receptor), and among its related pathways are Neurotransmitter uptake and Metabolism In Glial Cells and Glutamic acid signaling. The compounds peneca and psb-10 have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and heart, and related mouse phenotypes are vision/eye and renal/urinary system.

Disease Ontology:8 A vascular disease that is characterized by a restriction in blood supply to tissues.

Related Diseases for Ischemia

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Diseases related to Ischemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 505)
idRelated DiseaseScoreTop Affiliating Genes
1brain ischemia32.2HSPA4, ADORA3, ADORA1, NOS3
2transient cerebral ischemia32.1HSPA4, ADORA1, PLA2G2A
3coronary artery disease31.1XDH, HSPA4, PLA2G2A, NOS3
4vascular disease30.8XDH, SOD1, NOS3, CTSL
5dementia30.5SLC1A2, SLC1A3, HSPA4
6acute chest syndrome30.5NOS3, PLA2G2A
7atherosclerosis30.4XDH, HSPA4, SOD1, PRKAA2, PLA2G2A, NOS3
8pneumonia30.2ADORA2A, HSPA4, XDH
9asthma30.0XDH, HSPA4, ADORA3, ADORA1, ADORA2A, PLA2G2A
10diabetes mellitus, noninsulin-dependent30.0ADORA1, PRKAA2, PLA2G2A, NOS3
11rheumatoid arthritis29.9ADORA3, ADORA1, ADORA2A, PLA2G2A, CTSL
12breast cancer29.9XDH, HSPA4, ADORA3, PRKAA2, PRKCE, PLA2G2A
13schizophrenia29.8XDH, HSPA4, ADORA2A, PLA2G2A, SLC1A1, SLC1A3
14melanoma29.7XDH, HSPA4, ADORA3, ADORA2A, PRKCE, PLA2G2A
15cerebritis11.3
16limb ischemia11.2
17critical limb ischemia11.1
18neuronitis11.1
19retinitis11.0
20retinal ischemia11.0
21hypoxia11.0
22endotheliitis10.8
23cerebral hypoxia10.8
24aneurysm10.7
25hepatitis10.7
26artery disease10.6
27aortic aneurysm10.6
28myocardial infarction10.6
29cerebral artery occlusion10.6
30chronic myocardial ischemia10.5
31brain edema10.5
32brain injury10.5
33mild pre-eclampsia10.5SOD1
34myocardial stunning10.5
35hypermethioninemia10.4SOD1
36hyperglycemia10.4
37abdominal aortic aneurysm10.4
38carotid artery occlusion10.4
39angina pectoris10.4
40paraplegia10.4
41blindness10.4
42temporal lobe epilepsy10.4ADORA1, SLC1A1, SLC1A3, SLC1A2
43toxic encephalopathy10.4HSPA4, SLC1A3, SLC1A2
44peripheral artery disease10.3
45mesenteric artery ischemia10.3
46coronary stenosis10.3
47peripheral vascular disease10.3
48anoxia10.3
49prion disease10.3ADORA1, PLA2G2A, SLC1A3, SLC1A2
50motor neuron disease10.3HSPA4, SOD1, SLC1A3, SLC1A2

Graphical network of the top 20 diseases related to Ischemia:



Diseases related to ischemia

Symptoms for Ischemia

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Drugs & Therapeutics for Ischemia

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Drug clinical trials:

Search ClinicalTrials for Ischemia

Search NIH Clinical Center for Ischemia

Genetic Tests for Ischemia

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Anatomical Context for Ischemia

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MalaCards organs/tissues related to Ischemia:

31
Brain, Spinal cord, Heart, Endothelial, Liver, Bone, Kidney, Lung, Bone marrow, Skeletal muscle, Neutrophil, Cortex, Colon, Testes, Skin, Monocytes, Small intestine, Retina, T cells, Cardiac myocytes, Olfactory bulb, B cells, Pituitary, Eye, Pancreas, Breast, Prostate, Smooth muscle, Spleen, Thyroid, Placenta, Testis, Prefrontal cortex, Lymph node, Cerebellum, Salivary gland, Ovary, Myeloid, Fetal brain, Globus pallidus, Caudate nucleus, Amygdala, Pancreatic islet

Animal Models for Ischemia or affiliated genes

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Publications for Ischemia

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Articles related to Ischemia:

(show top 50)    (show all 5581)
idTitleAuthorsYear
1
Patent foramen ovale and gut ischemia in potential intestinal transplant recipients. (25221903)
2014
2
Real-time trafficking of PEGylated liposomes in the rodent focal brain ischemia analyzed by positron emission tomography. (25295359)
2014
3
Comparison of graft patency, limb salvage, and antithrombotic therapy between prosthetic and autogenous below-knee bypass for critical limb ischemia. (24011814)
2013
4
Verapamil augments the neuroprotectant action of berberine in rat model of transient global cerebral ischemia. (24177287)
2013
5
Aldosterone synthase gene (CYP11B2) -344C/T polymorphism contributes to the risk of recurrent cerebral ischemia. (23701507)
2013
6
Effect of cation type and concentration of nitrates on neurological disorders during experimental cerebral ischemia. (24288757)
2013
7
Arteriographic findings in diabetic and non-diabetic with critical limb ischemia. (24211015)
2013
8
The relationship between ischemia modified albumin and oxidative stress parameters in patients with cardiac syndrome X. (24409667)
2013
9
Neuroprotective effect of melatonin against ischemia is partially mediated by alpha-7 nicotinic receptor modulation and HO-1 overexpression. (24350834)
2013
10
Bifurcation stenting after failed angioplasty of infrapopliteal arteries in critical limb ischemia: techniques and short-term follow-up. (23404942)
2013
11
The vulnerability of nitrergic neurons to transient spinal cord ischemia: a quantitative immunohistochemical and histochemical study. (22228218)
2012
12
Acute mesenteric ischemia and duodenal ulcer perforation: a unique double pathology. (23110681)
2012
13
Spinal cord ischemia occurring in association with induced hypotension for colonic surgery. (22075019)
2012
14
Plasma proteomic analysis of the critical limb ischemia markers in diabetic patients with hemodialysis. (21468429)
2011
15
Endovascular management of patients with critical limb ischemia. (21211929)
2011
16
Ischemia induced peroxynitrite dependent modifications of cardiomyocyte MLC1 increases its degradation by MMP-2 leading to contractile dysfunction. (20518849)
2011
17
Hypoxia-ischemia induces hypo-phosphorylation of collapsin response mediator protein 2 in a neonatal rat model of periventricular leukomalacia. (21333637)
2011
18
Transplantation of human mesenchymal stem cells promotes functional improvement and increased expression of neurotrophic factors in a rat focal cerebral ischemia model. (19885863)
2010
19
Transient middle cerebral artery occlusion in rats as an experimental model of brain ischemia. (20877953)
2010
20
Understanding objective performance goals for critical limb ischemia trials. (20826289)
2010
21
Lack of adrenomedullin, but not complement factor H, results in larger infarct size and more extensive brain damage in a focal ischemia model. (20854881)
2010
22
Antioxidant properties of alpha-lipoic acid: effects on red blood membrane permeability and adaptation of isolated rat heart to reversible ischemia. (18839280)
2009
23
Fate and manipulations of endogenous neural stem cells following brain ischemia. (19653861)
2009
24
Severe acute ocular ischemia associated with spontaneous internal carotid artery dissection. (17999033)
2008
25
Individual treatment strategies for patients suffering from critical limb ischemia are mandatory. (17390300)
2007
26
Subintimal angioplasty as the first-choice revascularization technique for infrainguinal arterial occlusions in patients with critical limb ischemia. (17980800)
2007
27
Peroxisome proliferator-activated receptors ligands and ischemia-reperfusion injury. (17394034)
2007
28
Current opinions regarding the spinal cord ischemia syndrome. (18386602)
2006
29
CD40/CD40 ligand signaling in mouse cerebral microvasculature after focal ischemia/reperfusion. (15795333)
2005
30
Neuroprotection afforded by prior citicoline administration in experimental brain ischemia: effects on glutamate transport. (15686962)
2005
31
Inflammation and ischemia: macrophages activated by fibronectin fragments enhance the survival of injured cardiac myocytes. (15169973)
2004
32
Diffusion-weighted MR imaging in acute spinal cord ischemia. (15022011)
2004
33
Recombinant t-PA in myocardial ischemia after switch operation. (15054563)
2004
34
Overexpression of SSAT in kidney cells recapitulates various phenotypic aspects of kidney ischemia-reperfusion injury. (15213272)
2004
35
The temporal profile of the reaction of microglia, astrocytes, and macrophages in the delayed onset paraplegia after transient spinal cord ischemia in rabbits. (12761011)
2003
36
Endothelial nitric oxide synthase expression in ischemia-reperfusion injury after living related-donor renal transplantation. (12478411)
2002
37
In vivo models of myocardial ischemia and reperfusion injury: application to drug discovery and evaluation. (11150743)
2000
38
Effect of dopamine blockers on cerebral ischemia-induced hyperactivity in gerbils. (10336152)
1999
39
Prevention of both T2- and diffusion-weighted increases in image intensity during cerebral hypoxia-ischemia in infant rats pretreated with dexamethasone. (10204774)
1999
40
BDNF diminishes caspase-2 but not c-Jun immunoreactivity of neurons in retinal ganglion cell layer after transient ischemia. (10549664)
1999
41
Delayed recovery of auditory cortical evoked potentials is correlated with cortical neuronal death after transient cerebral ischemia in awake gerbils. (9739151)
1998
42
Cytokines and adhesion molecules in elective and accidental trauma-related ischemia/reperfusion. (9603092)
1998
43
Blood-retinal barrier breakdown following experimental retinal ischemia and reperfusion. (8654497)
1995
44
The effects of naloxone on retinal ischemia in rats. (8083567)
1994
45
Human recombinant extracellular-superoxide dismutase type C improves cardioplegic protection against ischemia/reperfusion injury in isolated rat heart. (7528849)
1994
46
Retinal ischemia and cell proliferation in the rat: the role of soluble mitogens. (2338257)
1990
47
Lack of conversion of xanthine dehydrogenase to xanthine oxidase during warm renal ischemia. (2253787)
1990
48
Effect of peroxide, sodium, and calcium on brain mitochondrial respiration in vitro: potential role in cerebral ischemia and reperfusion. (2313294)
1990
49
Neurological outcome correlated with spinal evoked potentials in a spinal cord ischemia model. (6707748)
1984
50
Management of transient cerebral ischemia. (573393)
1979

Variations for Ischemia

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Expression for genes affiliated with Ischemia

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Search GEO for disease gene expression data for Ischemia.

Pathways for genes affiliated with Ischemia

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Pathways related to Ischemia according to GeneCards Suite gene sharing:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.2SLC1A3, SLC1A2
2
Show member pathways
10.1ADORA1, ADORA3, ADORA2A
3
Show member pathways
Development A1 receptor signaling59
G protein signaling G Protein alpha q signaling cascades59
10.0ADORA3, PRKCE, ADORA1
4
Show member pathways
9.9XDH, SOD1, NOS3
5
Show member pathways
Development A2B receptor action via G protein alpha s59
9.9PRKCE, ADORA2A, NOS3
6
Show member pathways
9.9SLC1A1, SLC1A7, SLC1A6
79.9SLC1A3, SLC1A2, SLC1A1, SOD1
8
Show member pathways
Amyotrophic lateral sclerosis (ALS)36
9.9SLC1A2, SLC1A3, SLC1A1, SOD1
9
Show member pathways
9.9HSPA4, SOD1, NOS3
10
Show member pathways
Development EDNRB signaling59
Development ACM2 and ACM4 activation of ERK59
Cell adhesion Integrin inside out signaling59
Development G Proteins mediated regulation MARK ERK signaling59
Signal transduction IP3 signaling59
Development Angiotensin signaling via PYK259
Development EPO induced MAPK pathway59
9.8ADORA3, ADORA2A, PRKCE, NOS3
11
Show member pathways
9.6PLA2G2A, PRKCE, PRKAA2, NOS3, ADORA2A
12
Show member pathways
9.6SLC1A2, SLC1A6, SLC1A3, SLC1A7, SLC1A1
13
Show member pathways
9.6SLC1A2, SLC1A3, SLC1A1, SLC1A7, SLC1A6
14
Show member pathways
9.5ADORA1, SLC1A1, SLC1A7, SLC1A3, SLC1A6, SLC1A2

Compounds for genes affiliated with Ischemia

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Sources:
28IUPHAR, 44Novoseek, 24HMDB, 11DrugBank, 60Tocris Bioscience
See all sources

Compounds related to Ischemia according to GeneCards Suite gene sharing:

(show top 50)    (show all 221)
idCompoundScoreTop Affiliating Genes
1peneca2810.4ADORA2A, ADORA1, ADORA3
2psb-102810.4ADORA3, ADORA1, ADORA2A
3(r,s)-phpneca2810.4ADORA1, ADORA3, ADORA2A
4apadenoson2810.4ADORA3, ADORA1, ADORA2A
5mrs51512810.4ADORA3, ADORA1, ADORA2A
6psb-112810.4ADORA3, ADORA1, ADORA2A
7dihydrokainate44 2811.4SLC1A2, SLC1A3, SLC1A1
8las380962810.4ADORA3, ADORA1, ADORA2A
9cyclopentyladenosine2810.4ADORA3, ADORA1, ADORA2A
10atl8022810.4ADORA1, ADORA2A, ADORA3
11(s)-pia2810.4ADORA3, ADORA1, ADORA2A
12cvt-68832810.3ADORA2A, ADORA1, ADORA3
13tonapofylline2810.3ADORA3, ADORA1, ADORA2A
14cl-ib-meca2810.3ADORA3, ADORA1, ADORA2A
15n(6)-cyclohexyladenosine44 2811.3ADORA1, ADORA2A, ADK, ADORA3
16mrs15232810.3ADORA3, ADORA1, ADORA2A
17adenosine28 24 1112.3ADK, ADORA1, ADORA2A, ADORA3
18(r)-pia2810.3ADORA3, ADORA1, ADORA2A
195-diethoxyphosphoryl-5-methyl-1-pyrroline n-oxide4410.3NOS3, SOD1, XDH
20neca2810.3ADORA3, ADORA1, ADORA2A
218-phenyltheophylline4410.3ADORA1, ADK, ADORA2A
22sch 5826160 2811.2ADORA3, ADORA1, ADORA2A
238-(p-sulfophenyl)theophylline4410.2ADORA3, ADORA1, ADORA2A
248-cyclopentyltheophylline4410.1ADK, ADORA1, ADORA2A
252-hexynyl-neca2810.1ADORA2A, ADORA1, ADORA3
26theophylline44 28 24 1113.1ADK, ADORA3, XDH, ADORA1, ADORA2A
27tfb-tboa6010.1SLC1A7, SLC1A6, SLC1A2, SLC1A1, SLC1A3
28[3h]etb-tboa2810.1SLC1A2, SLC1A6, SLC1A3, SLC1A7, SLC1A1
29rolofylline2810.1ADORA3, ADORA1, ADORA2A
30l-trans-2,4-pdc6010.1SLC1A1, SLC1A7, SLC1A3, SLC1A6, SLC1A2
31msx-22810.1ADORA3, ADORA1, ADORA2A
32[3h]d-aspartic acid2810.1SLC1A6, SLC1A1, SLC1A7, SLC1A3, SLC1A2
33[3h]l-aspartic acid2810.1SLC1A2, SLC1A6, SLC1A3, SLC1A7, SLC1A1
34way 2136136010.1SLC1A1, SLC1A7, SLC1A2, SLC1A6, SLC1A3
35dihydrokainic acid6010.0SLC1A1, SLC1A7, SLC1A3, SLC1A2, SLC1A6
36dl-tboa60 2811.0SLC1A1, SLC1A7, SLC1A3, SLC1A6, SLC1A2
37cgs 216802810.0ADORA3, ADORA1, ADORA2A
38l-glutamic acid28 24 1111.9SLC1A3, SLC1A6, SLC1A7, SLC1A1, SLC1A2
39xanthine44 2410.8XDH, SOD1, NOS3, ADK, ADORA3, ADORA1
40kainate44 2810.8ADORA1, HSPA4, ADK, ADORA2A, SLC1A1, SLC1A3
41st-1535289.8ADORA3, ADORA1, ADORA2A
42aspartate449.5HSPA4, ADORA1, ADORA2A, CTSL, SLC1A1, SLC1A3
43adenylate449.5PRKAA2, PLA2G2A, SLC1A3, ADK, HSPA4, SLC1A2
44nitric oxide44 24 1111.4PRKAA2, NOS3, HSPA4, SLC1A3, SLC1A2, XDH
45oxygen44 2410.4SOD1, XDH, ADORA3, NOS3, ADORA2A, PRKAA2
46nmda44 2810.4ADORA1, ADK, HSPA4, PLA2G2A, SLC1A1, SLC1A7
47alanine449.4HSPA4, PRKAA2, ADORA1, SOD1, CTSL, SLC1A1
48superoxide44 2410.2SOD1, ADORA3, PRKAA2, PLA2G2A, SLC1A2, XDH
49serine449.0PRKAA2, ADORA2A, SLC1A2, SLC1A3, CTSL, PLA2G2A
50glutamate448.4SLC1A2, HSPA4, SOD1, ADORA3, ADORA1, ADORA2A

GO Terms for genes affiliated with Ischemia

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Cellular components related to Ischemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1presynaptic active zoneGO:004878610.2ADORA2A, ADORA1
2axolemmaGO:003067310.2SLC1A2, ADORA2A, ADORA1
3asymmetric synapseGO:00322799.9ADORA2A, ADORA1
4neuronal cell bodyGO:00430259.8SOD1, ADORA1, ADORA2A, SLC1A3
5membraneGO:00160209.5YRDC, ADORA2A, SLC1A1, SLC1A3, SLC1A6, SLC1A2
6plasma membraneGO:00058868.7SOD1, ADORA3, ADORA1, ADORA2A, PRKCE, NOS3

Biological processes related to Ischemia according to GeneCards Suite gene sharing:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of mucus secretionGO:007025710.4ADORA3, PRKCE
2relaxation of vascular smooth muscleGO:006008710.4ADORA1, SOD1
3D-aspartate importGO:007077910.4SLC1A2, SLC1A3, SLC1A1
4L-glutamate importGO:005193810.4SLC1A2, SLC1A3, SLC1A1
5response to woundingGO:000961110.3SLC1A2, SLC1A3, ADORA3
6positive regulation of synaptic transmission, GABAergicGO:003223010.3ADORA2A, PRKCE
7regulation of mitochondrial membrane potentialGO:005188110.2ADORA2A, SOD1
8L-glutamate transportGO:001581310.2SLC1A7, SLC1A6
9negative regulation of blood pressureGO:004577610.1NOS3, ADORA1
10regulation of excitatory postsynaptic membrane potentialGO:006007910.1ADORA2A, ADORA1
11response to drugGO:004249310.0SLC1A2, SLC1A3, ADORA2A, SOD1
12synaptic transmissionGO:000726810.0SLC1A1, SLC1A3, SLC1A6, SLC1A2
13ion transportGO:00068119.9SLC1A1, SLC1A7, SLC1A3, SLC1A6, SLC1A2
14transmembrane transportGO:00550859.8SLC1A1, SLC1A7, SLC1A3, SLC1A6, SLC1A2
15blood coagulationGO:00075969.8SOD1, ADORA2A, PRKCE, NOS3
16signal transductionGO:00071659.4SMOC2, ADORA3, ADORA1, PRKAA2, PRKCE

Molecular functions related to Ischemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1glutamate:sodium symporter activityGO:001550110.1SLC1A1, SLC1A2
2actin monomer bindingGO:000378510.1NOS3, PRKCE
3G-protein coupled adenosine receptor activityGO:000160910.1ADORA2A, ADORA1, ADORA3
4glutamate bindingGO:00165959.9SLC1A3, SLC1A1
5sodium:dicarboxylate symporter activityGO:00171539.7SLC1A2, SLC1A6, SLC1A3, SLC1A7, SLC1A1
6L-glutamate transmembrane transporter activityGO:00053139.7SLC1A1, SLC1A7, SLC1A3, SLC1A6, SLC1A2

Sources for Ischemia

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet