MCID: ISC004
MIFTS: 64

Ischemia malady

Summaries for Ischemia

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63Wikipedia, 32MalaCards
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Wikipedia:63 In medicine, ischemia, also spelled as ischaemia or ischæmia, (/ɪˈskiːmɪə/;[a]) is a restriction... more...

MalaCards: Ischemia is related to transient cerebral ischemia and spinal cord ischemia. An important gene associated with Ischemia is ADORA3 (adenosine A3 receptor), and among its related pathways are Circadian entrainment and Amino acid and oligopeptide SLC transporters. The compounds glutamate and superoxide have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and heart, and related mouse phenotypes are homeostasis/metabolism and behavior/neurological.

Aliases & Classifications for Ischemia

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
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Aliases & Descriptions:

ischemia 8 44 60


External Ids:

Disease Ontology8 DOID:326
NCIt39 C34738
SNOMED-CT56 52674009
MeSH34 D007511

Related Diseases for Ischemia

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17GeneCards, 18GeneDecks
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Diseases related to Ischemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 467)
idRelated DiseaseScoreTop Affiliating Genes
1transient cerebral ischemia31.6HSPA4, PLA2G2A, ADORA1
2spinal cord ischemia31.6PLA2G2A
3hepatitis31.0XDH
4myocardial infarction30.9NOS3
5hypertension30.8NOS3
6coronary artery disease30.7HSPA4, PLA2G2A, NOS3, ADORA1, ADORA2A
7diabetes mellitus30.5HSPA4, SOD1, NOS3
8vascular disease30.4SOD1, CTSL, XDH, NOS3
9ischemic heart disease30.3SOD1, PRKAA2, PLA2G2A, NOS3, ADORA1
10atherosclerosis30.3HSPA4, SOD1, CTSL, PRKAA2, XDH, PLA2G2A
11type 2 diabetes mellitus30.3HSPA4, SOD1, PRKAA2, NOS3, ADORA1
12brain ischemia30.3HSPA4, NOS3, ADORA1, ADORA3
13pancreatitis30.2SOD1, PLA2G2A
14alzheimer's disease30.2SOD1, CTSL, PLA2G2A, SLC1A2, SLC1A3, NOS3
15glaucoma30.1ADORA3, ADORA1
16dementia30.1HSPA4, SLC1A2, SLC1A3
17migraine30.1SLC1A3
18meningioma29.9CTSL
19cadasil29.8HSPA4, PLA2G2A, SLC1A2, SLC1A3, NOS3, ADORA1
20asthma29.8HSPA4, XDH, PLA2G2A, ADORA1, ADORA3, ADORA2A
21breast cancer29.8HSPA4, CTSL, PRKAA2, PRKCE, XDH, PLA2G2A
22essential hypertension29.8SOD1, XDH, NOS3, ADORA2A
23colorectal cancer29.8PLA2G2A, XDH, CTSL
24pneumonia29.8HSPA4, XDH, ADORA2A
25schizophrenia29.6HSPA4, XDH, PLA2G2A, SLC1A2, SLC1A1, SLC1A3
26melanoma29.6HSPA4, CTSL, PRKCE, XDH, PLA2G2A, ADORA3
27rheumatoid arthritis29.6ADORA2A, ADORA3, ADORA1, PLA2G2A, CTSL
28motor neuron disease29.6HSPA4, SOD1, SLC1A2, SLC1A3
29leukemia29.6HSPA4, CTSL, PLA2G2A, ADORA3
30pre-eclampsia29.6NOS3, PLA2G2A, XDH, SOD1
31arthritis29.6ADORA3, PLA2G2A, CTSL
32multiple sclerosis29.6ADORA1, XDH
33malaria29.6XDH, HSPA4
34huntington's disease29.6ADORA2A, SLC1A2
35hepatopulmonary syndrome29.5NOS3
36cerebritis11.2
37critical limb ischemia11.1
38neuronitis11.0
39retinal ischemia10.9
40retinitis10.9
41cerebral artery occlusion10.6
42aortic aneurysm10.5
43brain edema10.5
44myocardial stunning10.4
45hyperglycemia10.4
46abdominal aortic aneurysm10.4
47carotid artery occlusion10.4
48acute myocardial infarction10.4
49paraplegia10.3
50angina pectoris10.3

Graphical network of the top 20 diseases related to Ischemia:



Diseases related to ischemia

Clinical Features for Ischemia

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Drugs & Therapeutics for Ischemia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Ischemia

Drug clinical trials:

Search ClinicalTrials for Ischemia

Search NIH Clinical Center for Ischemia

Search CenterWatch for Ischemia

Genetic Tests for Ischemia

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Anatomical Context for Ischemia

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32MalaCards
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MalaCards organs/tissues related to Ischemia:

32
Brain, Spinal cord, Heart, Endothelial, Liver, Kidney, Bone, Lung, Bone marrow, Skeletal muscle, Cortex, Colon, Testes, Skin, Monocytes, Small intestine, Retina, T cells, Cardiac myocytes, Olfactory bulb, B cells, Pituitary, Prostate, Eye, Breast, Pancreas, Smooth muscle, Placenta, Spleen, Thyroid, Testis, Prefrontal cortex, Globus pallidus, Fetal brain, Pancreatic islet, Ovary, Lymph node, Cerebellum, Amygdala, Myeloid, Caudate nucleus

Animal Models for Ischemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Ischemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537613.0PRKCE, ADORA2A, ADORA3, NOS3, ADORA1, ADK
2MP:000538612.9HSPA4, ADORA1, NOS3, SLC1A1, SLC1A2, SLC1A7
3MP:000363112.4HSPA4, SOD1, ADORA1, PRKAA2, SLC1A2, SLC1A1
4MP:000538412.2HSPA4, SLC1A3, SLC1A1, SLC1A2, XDH, SOD1
5MP:000539111.8SOD1, ADORA3, NOS3, SLC1A3, SLC1A1, CTSL
6MP:000536711.4CTSL, PRKAA2, XDH, SLC1A1, NOS3, ADORA1

Publications for Ischemia

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50PubMed
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Articles related to Ischemia:

(show top 50)    (show all 5367)
idTitleAuthorsYear
1
Comparison of graft patency, limb salvage, and antithrombotic therapy between prosthetic and autogenous below-knee bypass for critical limb ischemia. (24011814)
2013
2
The GluN3A subunit exerts a neuroprotective effect in brain ischemia and the hypoxia process. (23883441)
2013
3
Topical Nitroglycerine for Neonatal Arterial Associated Peripheral Ischemia following Cannulation: A Case Report and Comprehensive Literature Review. (24251058)
2013
4
Intrauterine upper limb ischemia: an unusual presentation of fetal thrombophilia-a case report and review of the literature. (24223318)
2013
5
Interferon regulatory factor-2 is protective against hepatic ischemia-reperfusion injury. (22744333)
2012
6
Association of diabetes and hemodialysis with ankle pressure and ankle-brachial index in Japanese patients with critical limb ischemia. (22723344)
2012
7
Increase of 20-HETE synthase after brain ischemia in rats revealed by PET study with 11C-labeled 20-HETE synthase-specific inhibitor. (22669478)
2012
8
3-n-Butylphthalide (NBP) attenuated neuronal autophagy and amyloid-I^ expression in diabetic mice subjected to brain ischemia. (21535939)
2011
9
Esmolol and landiolol, selective beta1-adrenoreceptor antagonists, provide neuroprotection against spinal cord ischemia and reperfusion in rats. (20103544)
2010
10
Ischemia-modified albumin in differential diagnosis of acute coronary syndrome without ST elevation and unstable angina pectoris. (20425705)
2010
11
The timing of perinatal hypoxia/ischemia events in term neonates: a retrospective autopsy study. HSPs, ORP-150 and COX2 are reliable markers to classify acute, perinatal events. (20626887)
2010
12
Sensing muscle ischemia: coincident detection of acid and ATP via interplay of two ion channels. (21092862)
2010
13
A study of the protective effects of lidocaine and nerve growth factor pretreatment on cerebral ischemia/reperfusion injury in gerbils]. (20398469)
2010
14
Docosahexaenoic acid pretreatment confers neuroprotection in a rat model of perinatal cerebral hypoxia-ischemia. (19254588)
2009
15
Heme oxygenase expression in human placental villous tissue in response to exposure to in vitro ischemia-reperfusion injury. (19263288)
2009
16
Protection from pulmonary ischemia-reperfusion injury by adenosine A2A receptor activation. (19558673)
2009
17
The correlation between quantitative T2' and regional cerebral blood flow after acute brain ischemia in early reperfusion as demonstrated in a middle cerebral artery occlusion/reperfusion model of the rat. (19103223)
2009
18
Enhancing limb salvage by non-mobilized peripheral blood angiogenic cell precursors therapy in patients with critical limb ischemia. (19301723)
2009
19
Osteopontin protects against cardiac ischemia-reperfusion injury through late preconditioning. (19337795)
2009
20
Imaging changes in lymphoid organs in vivo after brain ischemia with three-dimensional fluorescence molecular tomography in transgenic mice expressing green fluorescent protein in T lymphocytes. (19123986)
2008
21
Estrogen protects the heart from ischemia-reperfusion injury via COX-2-derived PGI2. (18806603)
2008
22
Imaging of the inflammatory response in reperfusion injury after transient cerebral ischemia in rats: correlation of superparamagnetic iron oxide-enhanced magnetic resonance imaging with histopathology. (18568546)
2008
23
Coronary microvascular dysfunction in the setting of chronic ischemia is independent of arginase activity. (17707069)
2008
24
Thrombotic thrombocytopenic purpura: inducible myocardial ischemia depicted on dipyridamole stress first-pass perfusion cardiac magnetic resonance despite normal myocardial stress single-photon emission computed tomography. (18695197)
2008
25
Effects of cyclosporin a on neurological outcome and serum biomarkers in the same setting of spinal cord ischemia model. (16609830)
2006
26
Acute spinal cord ischemia during aortography treated with intravenous thrombolytic therapy. (16572877)
2006
27
Neuroprotection afforded by prior citicoline administration in experimental brain ischemia: effects on glutamate transport. (15686962)
2005
28
Immunophilin ligands FK506 and cyclosporine A improve neurologic and histopathologic outcome after transient spinal cord ischemia in rabbits. (15632833)
2005
29
Atorvastatin: gold standard for prophylaxis of myocardial ischemia and stroke - comparison of the clinical benefit of statins on the basis of randomized controlled endpoint studies. (14766335)
2004
30
Endovascular treatment of a traumatic thoracic aortic aneurysm initially presenting as acute critical limb ischemia. (15224466)
2004
31
Excimer laser-assisted high-flow extracranial/intracranial bypass in patients with symptomatic carotid artery occlusion at high risk of recurrent cerebral ischemia: safety and long-term outcome. (12364737)
2002
32
N-methyl-D-aspartate receptor and L-type voltage-gated Ca(2+) channel antagonists suppress the release of cytochrome c and the expression of procaspase-3 in rat hippocampus after global brain ischemia. (12147322)
2002
33
Effect of endogenous catecholamine on myocardial stunning in a simulated ischemia model. (11468020)
2001
34
Alleviation of myocardial ischemia after Kawasaki disease by heparin and exercise therapy. (11382729)
2001
35
Nuclear factor-kappa B decoy attenuates neuronal damage after global brain ischemia: a future strategy for brain protection during circulatory arrest. (11581604)
2001
36
Effect of xinmaitong capsule on total ischemia burden in coronary heart disease patients with myocardial ischemia and analysis of its therapeutical mechanism]. (11783328)
2000
37
Ischemia-induced phosphorylation of initiation factor 2 in differentiated PC12 cells: role for initiation factor 2 phosphatase. (11080185)
2000
38
A novel assay for cobalt-albumin binding and its potential as a marker for myocardial ischemia-a preliminary report. (11074321)
2000
39
Differential regulation of vascular endothelial growth factor during ventilated pulmonary ischemia. (10424577)
1999
40
Spinal cord monitoring with myogenic motor evoked potentials: early detection of spinal cord ischemia as an integral part of spinal cord protective strategies during thoracoabdominal aneurysm surgery. (9469773)
1998
41
Activation of gadd153 expression through transient cerebral ischemia: evidence that ischemia causes endoplasmic reticulum dysfunction. (9748529)
1998
42
Age-related ischemia in the brain following bilateral carotid artery occlusion--collateral blood flow and brain metabolism. (9021760)
1997
43
Tourniquet-induced exsanguination in patients requiring lower limb surgery. An ischemia-reperfusion model of oxidant and antioxidant metabolism. (8572327)
1996
44
Effect of nitroglycerin on spinal cord ischemia after thoracic aortic cross-clamping. (8561534)
1996
45
Ventricular tachyarrhythmias, myocardial ischemia, and sudden cardiac death in patients with hypertensive heart disease. (7554542)
1995
46
Shed blood autotransfusion influences ischemia-sensitive laboratory parameters after coronary operations. (8179401)
1994
47
Failure of selective shunting to intercostal arteries to prevent spinal cord ischemia during experimental thoracoabdominal aortic occlusion. (1295934)
1992
48
Effect of peroxide, sodium, and calcium on brain mitochondrial respiration in vitro: potential role in cerebral ischemia and reperfusion. (2313294)
1990
49
Neuronal damage and calcium accumulation following transient cerebral ischemia in the rat. (2091666)
1990
50
Significance of ulcerated plaque in transient cerebral ischemia. (7212183)
1981

Genetic Variations for Ischemia

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Expression for genes affiliated with Ischemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ischemia

Search GEO for disease gene expression data for Ischemia.

Pathways for genes affiliated with Ischemia

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Sources:
29KEGG, 53Reactome, 4Cell Signaling Technology, 51QIAGEN, 12EMD Millipore, 37NCBI BioSystems Database, 49PharmGKB
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Pathways related to Ischemia according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.5SLC1A2, ADORA1, SLC1A3, SLC1A6, SLC1A1, SLC1A7
2
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11.3SLC1A7, SLC1A2, SLC1A6, SLC1A3, SLC1A1
3
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11.3SLC1A7, SLC1A2, SLC1A1, SLC1A6, SLC1A3
4
Hide members
11.3SLC1A3, SLC1A6, SLC1A1, SLC1A2, SLC1A7
511.2SOD1, SLC1A2, SLC1A1, SLC1A3
6
Hide members
11.2SLC1A3, SLC1A1, SOD1, SLC1A2
711.0SLC1A1, SLC1A3, SLC1A2
8
Hide members
11.0ADORA3, ADORA1, ADORA2A
911.0SLC1A1, SLC1A2, SOD1
10
Signal transduction IP3 signaling
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11.0ADORA3, ADORA2A, PRKCE
11
Development A3 receptor signaling
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11.0PRKCE, ADORA1, ADORA3
12
Development A2B receptor- action via G-protein alpha s
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11.0NOS3, ADORA2A, PRKCE
13
Hide members
11.0NOS3, XDH, SOD1
14
Hide members
11.0SLC1A7, SLC1A1, SLC1A6
15
Hide members
11.0SLC1A7, SLC1A1, SLC1A6
16
CFTR folding and maturation (norm and CF)
11.0NOS3, SOD1, HSPA4
17
Hide members
10.8SLC1A2, SLC1A3

Compounds for genes affiliated with Ischemia

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Sources:
44Novoseek, 24HMDB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Ischemia according to GeneCards/GeneDecks:

(show top 50)    (show all 200)
idCompoundScoreTop Affiliating Genes
1glutamate4413.4HSPA4, ADORA3, ADORA1, NOS3, SLC1A3, SLC1A6
2superoxide44 2413.6SLC1A2, PLA2G2A, XDH, PRKAA2, CTSL, SOD1
3adenylate4412.5PLA2G2A, ADORA2A, SLC1A2, ADORA1, ADORA3, SLC1A3
4nitric oxide44 11 2414.5ADORA3, SLC1A3, HSPA4, SLC1A2, XDH, PRKAA2
5alanine4412.4CTSL, SOD1, HSPA4, PRKAA2, PLA2G2A, SLC1A2
6nmda44 2813.3ADK, HSPA4, SLC1A7, SLC1A2, SLC1A1, SLC1A3
7aspartate4412.3SLC1A3, HSPA4, SLC1A6, SLC1A1, SLC1A2, CTSL
8xanthine44 2413.1SOD1, ADORA1, XDH, NOS3, ADK, ADORA2A
9kainate44 2813.1HSPA4, ADK, ADORA2A, ADORA1, SLC1A3, SLC1A1
10serine4411.9CTSL, PRKAA2, PRKCE, PLA2G2A, SLC1A2, SLC1A3
11tfb-tboa5911.8SLC1A3, SLC1A7, SLC1A1, SLC1A2, SLC1A6
12dl-tboa59 2812.8SLC1A6, SLC1A3, SLC1A1, SLC1A7, SLC1A2
13[3h]d-aspartic acid2811.8SLC1A7, SLC1A3, SLC1A6, SLC1A1, SLC1A2
14way 2136135911.8SLC1A3, SLC1A6, SLC1A1, SLC1A2, SLC1A7
15dihydrokainic acid5911.8SLC1A7, SLC1A2, SLC1A1, SLC1A6, SLC1A3
16l-trans-2,4-pdc5911.8SLC1A3, SLC1A7, SLC1A2, SLC1A1, SLC1A6
17[3h]l-aspartic acid2811.8SLC1A3, SLC1A6, SLC1A1, SLC1A2, SLC1A7
18[3h]etb-tboa2811.8SLC1A7, SLC1A1, SLC1A2, SLC1A3, SLC1A6
19theophylline44 28 11 2414.7ADK, XDH, ADORA3, ADORA1, ADORA2A
20n(6)-cyclohexyladenosine44 2812.6ADORA2A, ADORA3, ADORA1, ADK
21adenosine28 11 2413.6ADORA2A, ADORA3, ADK, ADORA1
225-diethoxyphosphoryl-5-methyl-1-pyrroline n-oxide4411.4NOS3, SOD1, XDH
23dihydrokainate44 2812.4SLC1A2, SLC1A3, SLC1A1
24psb-112811.4ADORA2A, ADORA1, ADORA3
25mrs51512811.4ADORA3, ADORA2A, ADORA1
26psb-102811.4ADORA2A, ADORA1, ADORA3
27peneca2811.4ADORA1, ADORA3, ADORA2A
28(r,s)-phpneca2811.4ADORA2A, ADORA3, ADORA1
29apadenoson2811.4ADORA1, ADORA3, ADORA2A
30preladenant2811.3ADORA2A, ADORA3, ADORA1
31gs96672811.3ADORA2A, ADORA1, ADORA3
32bay60-65832811.3ADORA2A, ADORA3, ADORA1
33xac2811.3ADORA1, ADORA3, ADORA2A
34regadenoson44 28 1113.3ADORA2A, ADORA3, ADORA1
35biib0142811.3ADORA1, ADORA3, ADORA2A
36neca2811.3ADORA2A, ADORA3, ADORA1
372-hexynyl-neca2811.3ADORA2A, ADORA3, ADORA1
38msx-22811.3ADORA2A, ADORA3, ADORA1
39st-15352811.3ADORA2A, ADORA3, ADORA1
40cgs 159432811.2ADORA2A, ADORA3, ADORA1
41zm-2413852811.2ADORA2A, ADORA3, ADORA1
42ib-meca28 5912.2ADORA2A, ADORA3, ADORA1
43las380962811.2ADORA2A, ADORA3, ADORA1
44mre 2029f202811.2ADORA2A, ADORA3, ADORA1
45hemado2811.1ADORA2A, ADORA3, ADORA1
46fk-4532811.1ADORA2A, ADORA3, ADORA1
47cyclopentyladenosine2811.0ADORA1, ADORA3, ADORA2A
48atl8022811.0ADORA2A, ADORA3, ADORA1
49mrs17542810.9ADORA2A, ADORA3, ADORA1
50(r)-pia2810.7ADORA2A, ADORA3, ADORA1

GO Terms for genes affiliated with Ischemia

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Sources:
16Gene Ontology
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Cellular components related to Ischemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588612.5ADORA2A, SOD1, PRKCE, SLC1A7, SLC1A2, SLC1A1
2membraneGO:01602011.5YRDC, SLC1A2, SLC1A1, SLC1A6, SLC1A3, ADORA2A
3axolemmaGO:03067311.1ADORA2A, ADORA1, SLC1A2
4neuronal cell bodyGO:04302510.9SOD1, SLC1A3, ADORA1, ADORA2A
5presynaptic active zoneGO:04878610.8ADORA2A, ADORA1
6asymmetric synapseGO:03227910.7ADORA2A, ADORA1

Biological processes related to Ischemia according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1ion transportGO:00681111.6SLC1A3, SLC1A2, SLC1A6, SLC1A1, SLC1A7
2transmembrane transportGO:05508511.2SLC1A7, SLC1A1, SLC1A6, SLC1A3, SLC1A2
3D-aspartate importGO:07077911.2SLC1A2, SLC1A1, SLC1A3
4L-glutamate importGO:05193811.2SLC1A2, SLC1A1, SLC1A3
5response to woundingGO:00961111.2SLC1A2, ADORA3, SLC1A3
6positive regulation of mucus secretionGO:07025711.0PRKCE, ADORA3
7relaxation of vascular smooth muscleGO:06008710.9ADORA1, SOD1
8L-glutamate transportGO:01581310.9SLC1A6, SLC1A7
9response to drugGO:04249310.9SOD1, ADORA2A, SLC1A3, SLC1A2
10positive regulation of synaptic transmission, GABAergicGO:03223010.8ADORA2A, PRKCE
11regulation of mitochondrial membrane potentialGO:05188110.8SOD1, ADORA2A

Molecular functions related to Ischemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sodium:dicarboxylate symporter activityGO:01715311.5SLC1A7, SLC1A2, SLC1A1, SLC1A6, SLC1A3
2L-glutamate transmembrane transporter activityGO:00531311.4SLC1A7, SLC1A2, SLC1A1, SLC1A6, SLC1A3
3G-protein coupled adenosine receptor activityGO:00160911.0ADORA3, ADORA1, ADORA2A
4actin monomer bindingGO:00378510.8PRKCE, NOS3
5glutamate:sodium symporter activityGO:01550110.7SLC1A2, SLC1A1
6glutamate bindingGO:01659510.5SLC1A3, SLC1A1

Products for genes affiliated with Ischemia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Ischemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet