MCID: ISC004
MIFTS: 62

Ischemia malady

Cardiovascular diseases category

Summaries for Ischemia

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Wikipedia:64 Ischemia, also spelled as ischaemia or isch more...

MalaCards based summary: Ischemia is related to brain ischemia and transient cerebral ischemia. An important gene associated with Ischemia is ADORA3 (adenosine A3 receptor), and among its related pathways are Neurotransmitter uptake and Metabolism In Glial Cells and Glutamic acid signaling. The compounds apadenoson and mrs5151 have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and heart, and related mouse phenotypes are vision/eye and renal/urinary system.

Disease Ontology:9 A vascular disease that is characterized by a restriction in blood supply to tissues.

Aliases & Classifications for Ischemia

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Sources:
9Disease Ontology, 44Novoseek, 61UMLS, 34MeSH, 39NCIt, 56SNOMED-CT
See all sources

Ischemia, Aliases & Descriptions:

Name: Ischemia 9 44 61


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


External Ids:

Disease Ontology9 DOID:326
MeSH34 D007511
SNOMED-CT56 52674009
NCIt39 C34738

Related Diseases for Ischemia

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Diseases related to Ischemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 518)
idRelated DiseaseScoreTop Affiliating Genes
1brain ischemia32.2ADORA3, ADORA1, HSPA4, NOS3
2transient cerebral ischemia32.1ADORA1, HSPA4, PLA2G2A
3vascular disease30.7NOS3, SOD1, XDH, CTSL
4type 2 diabetes mellitus30.7NOS3, HSPA4, ADORA1, PRKAA2, SOD1
5hypercholesterolemia30.6NOS3, XDH, PLA2G2A
6dementia30.5SLC1A3, HSPA4, SLC1A2
7acute chest syndrome30.5NOS3, PLA2G2A
8sepsis30.4ADORA2A, NOS3, PLA2G2A, XDH
9atherosclerosis30.4CTSL, PRKAA2, XDH, HSPA4, SOD1, PLA2G2A
10coronary artery anomaly30.3NOS3, HSPA4, XDH, PLA2G2A
11insulin resistance30.3NOS3, PLA2G2A, PRKAA2, ADORA1
12essential hypertension30.3SOD1, NOS3, ADORA2A, XDH
13alzheimer's disease30.2PLA2G2A, NOS3, CTSL, SLC1A2, ADORA2A, SOD1
14pneumonia30.2XDH, ADORA2A, HSPA4
15huntington's disease30.1ADORA2A, SOD1, HSPA4, SLC1A2
16asthma30.1ADORA1, PLA2G2A, ADORA3, ADORA2A, HSPA4, XDH
17cerebrovascular disease30.0HSPA4, ADORA3, ADORA1, NOS3, SLC1A3, SLC1A2
18septic shock30.0XDH, PLA2G2A, NOS3
19pre-eclampsia29.9XDH, SOD1, NOS3, PLA2G2A
20rheumatoid arthritis29.9ADORA3, ADORA1, ADORA2A, CTSL, PLA2G2A
21breast cancer29.9HSPA4, ADORA3, PRKAA2, XDH, PRKCE, CTSL
22schizophrenia29.8ADORA2A, PLA2G2A, SLC1A3, XDH, SLC1A1, HSPA4
23melanoma29.7CTSL, XDH, HSPA4, ADORA2A, PRKCE, PLA2G2A
24cerebritis11.3
25limb ischemia11.2
26critical limb ischemia11.1
27neuronitis11.1
28retinitis11.0
29retinal ischemia11.0
30hypoxia10.9
31endotheliitis10.8
32cerebral hypoxia10.8
33aneurysm10.7
34hepatitis10.7
35artery disease10.6
36hypertension10.6
37myocardial infarction10.6
38aortic aneurysm10.6
39cerebral artery occlusion10.6
40chronic myocardial ischemia10.5
41brain edema10.5
42brain injury10.5
43mild pre-eclampsia10.5SOD1
44myocardial stunning10.5
45hypermethioninemia10.4SOD1
46hyperglycemia10.4
47abdominal aortic aneurysm10.4
48diabetes mellitus10.4
49carotid artery occlusion10.4
50toxic encephalopathy10.4SLC1A3, SLC1A2, HSPA4

Graphical network of the top 20 diseases related to Ischemia:



Diseases related to ischemia

Symptoms for Ischemia

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Drugs & Therapeutics for Ischemia

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Drug clinical trials:

Search ClinicalTrials for Ischemia

Search NIH Clinical Center for Ischemia

Genetic Tests for Ischemia

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Anatomical Context for Ischemia

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MalaCards organs/tissues related to Ischemia:

32
Brain, Spinal cord, Heart, Endothelial, Liver, Bone, Kidney, Lung, Bone marrow, Skeletal muscle, Neutrophil, Cortex, Colon, Testes, Skin, Monocytes, Small intestine, Retina, T cells, Olfactory bulb, Cardiac myocytes, B cells, Pituitary, Eye, Pancreas, Breast, Prostate, Smooth muscle, Spleen, Thyroid, Placenta, Testis, Prefrontal cortex, Lymph node, Cerebellum, Salivary gland, Ovary, Myeloid, Fetal brain, Globus pallidus, Caudate nucleus, Amygdala, Pancreatic islet

Animal Models for Ischemia or affiliated genes

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Publications for Ischemia

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Articles related to Ischemia:

(show top 50)    (show all 5486)
idTitleAuthorsYear
1
Patent foramen ovale and gut ischemia in potential intestinal transplant recipients. (25221903)
2014
2
Comparison of graft patency, limb salvage, and antithrombotic therapy between prosthetic and autogenous below-knee bypass for critical limb ischemia. (24011814)
2013
3
Verapamil augments the neuroprotectant action of berberine in rat model of transient global cerebral ischemia. (24177287)
2013
4
Aldosterone synthase gene (CYP11B2) -344C/T polymorphism contributes to the risk of recurrent cerebral ischemia. (23701507)
2013
5
Effect of cation type and concentration of nitrates on neurological disorders during experimental cerebral ischemia. (24288757)
2013
6
Arteriographic findings in diabetic and non-diabetic with critical limb ischemia. (24211015)
2013
7
The relationship between ischemia modified albumin and oxidative stress parameters in patients with cardiac syndrome X. (24409667)
2013
8
Neuroprotective effect of melatonin against ischemia is partially mediated by alpha-7 nicotinic receptor modulation and HO-1 overexpression. (24350834)
2013
9
Bifurcation stenting after failed angioplasty of infrapopliteal arteries in critical limb ischemia: techniques and short-term follow-up. (23404942)
2013
10
The vulnerability of nitrergic neurons to transient spinal cord ischemia: a quantitative immunohistochemical and histochemical study. (22228218)
2012
11
Acute mesenteric ischemia and duodenal ulcer perforation: a unique double pathology. (23110681)
2012
12
Spinal cord ischemia occurring in association with induced hypotension for colonic surgery. (22075019)
2012
13
Plasma proteomic analysis of the critical limb ischemia markers in diabetic patients with hemodialysis. (21468429)
2011
14
Endovascular management of patients with critical limb ischemia. (21211929)
2011
15
Ischemia induced peroxynitrite dependent modifications of cardiomyocyte MLC1 increases its degradation by MMP-2 leading to contractile dysfunction. (20518849)
2011
16
Hypoxia-ischemia induces hypo-phosphorylation of collapsin response mediator protein 2 in a neonatal rat model of periventricular leukomalacia. (21333637)
2011
17
Transplantation of human mesenchymal stem cells promotes functional improvement and increased expression of neurotrophic factors in a rat focal cerebral ischemia model. (19885863)
2010
18
Transient middle cerebral artery occlusion in rats as an experimental model of brain ischemia. (20877953)
2010
19
Understanding objective performance goals for critical limb ischemia trials. (20826289)
2010
20
Lack of adrenomedullin, but not complement factor H, results in larger infarct size and more extensive brain damage in a focal ischemia model. (20854881)
2010
21
Antioxidant properties of alpha-lipoic acid: effects on red blood membrane permeability and adaptation of isolated rat heart to reversible ischemia. (18839280)
2009
22
Fate and manipulations of endogenous neural stem cells following brain ischemia. (19653861)
2009
23
Severe acute ocular ischemia associated with spontaneous internal carotid artery dissection. (17999033)
2008
24
Individual treatment strategies for patients suffering from critical limb ischemia are mandatory. (17390300)
2007
25
Subintimal angioplasty as the first-choice revascularization technique for infrainguinal arterial occlusions in patients with critical limb ischemia. (17980800)
2007
26
Peroxisome proliferator-activated receptors ligands and ischemia-reperfusion injury. (17394034)
2007
27
Current opinions regarding the spinal cord ischemia syndrome. (18386602)
2006
28
CD40/CD40 ligand signaling in mouse cerebral microvasculature after focal ischemia/reperfusion. (15795333)
2005
29
Neuroprotection afforded by prior citicoline administration in experimental brain ischemia: effects on glutamate transport. (15686962)
2005
30
Inflammation and ischemia: macrophages activated by fibronectin fragments enhance the survival of injured cardiac myocytes. (15169973)
2004
31
Diffusion-weighted MR imaging in acute spinal cord ischemia. (15022011)
2004
32
Recombinant t-PA in myocardial ischemia after switch operation. (15054563)
2004
33
Overexpression of SSAT in kidney cells recapitulates various phenotypic aspects of kidney ischemia-reperfusion injury. (15213272)
2004
34
The temporal profile of the reaction of microglia, astrocytes, and macrophages in the delayed onset paraplegia after transient spinal cord ischemia in rabbits. (12761011)
2003
35
Endothelial nitric oxide synthase expression in ischemia-reperfusion injury after living related-donor renal transplantation. (12478411)
2002
36
In vivo models of myocardial ischemia and reperfusion injury: application to drug discovery and evaluation. (11150743)
2000
37
Effect of dopamine blockers on cerebral ischemia-induced hyperactivity in gerbils. (10336152)
1999
38
Prevention of both T2- and diffusion-weighted increases in image intensity during cerebral hypoxia-ischemia in infant rats pretreated with dexamethasone. (10204774)
1999
39
BDNF diminishes caspase-2 but not c-Jun immunoreactivity of neurons in retinal ganglion cell layer after transient ischemia. (10549664)
1999
40
Delayed recovery of auditory cortical evoked potentials is correlated with cortical neuronal death after transient cerebral ischemia in awake gerbils. (9739151)
1998
41
Cytokines and adhesion molecules in elective and accidental trauma-related ischemia/reperfusion. (9603092)
1998
42
Blood-retinal barrier breakdown following experimental retinal ischemia and reperfusion. (8654497)
1995
43
The effects of naloxone on retinal ischemia in rats. (8083567)
1994
44
Human recombinant extracellular-superoxide dismutase type C improves cardioplegic protection against ischemia/reperfusion injury in isolated rat heart. (7528849)
1994
45
Cerebral ischemia in a patient with protein S deficiency and carotid stenosis. (8056555)
1994
46
Retinal ischemia and cell proliferation in the rat: the role of soluble mitogens. (2338257)
1990
47
Lack of conversion of xanthine dehydrogenase to xanthine oxidase during warm renal ischemia. (2253787)
1990
48
Effect of peroxide, sodium, and calcium on brain mitochondrial respiration in vitro: potential role in cerebral ischemia and reperfusion. (2313294)
1990
49
Neurological outcome correlated with spinal evoked potentials in a spinal cord ischemia model. (6707748)
1984
50
Management of transient cerebral ischemia. (573393)
1979

Variations for Ischemia

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Expression for genes affiliated with Ischemia

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Expression patterns in normal tissues for genes affiliated with Ischemia

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Pathways for genes affiliated with Ischemia

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Pathways related to Ischemia according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.2SLC1A2, SLC1A3
2
Show member pathways
10.1SLC1A2, SLC1A3, SLC1A1
3
Show member pathways
10.1ADORA3, ADORA1, ADORA2A
410.0SOD1, SLC1A1, SLC1A2
5
Show member pathways
Development A1 receptor signaling59
G protein signaling G Protein alpha q signaling cascades59
10.0PRKCE, ADORA1, ADORA3
6
Show member pathways
9.9XDH, SOD1, NOS3
7
Show member pathways
Development A2B receptor action via G protein alpha s59
9.9NOS3, PRKCE, ADORA2A
8
Show member pathways
9.9SLC1A6, SLC1A7, SLC1A1
9
Show member pathways
Amyotrophic lateral sclerosis (ALS)37
9.9SOD1, SLC1A1, SLC1A3, SLC1A2
109.9SOD1, SLC1A1, SLC1A3, SLC1A2
11
Show member pathways
9.9HSPA4, SOD1, NOS3
12
Show member pathways
Development EDNRB signaling59
Development ACM2 and ACM4 activation of ERK59
Cell adhesion Integrin inside out signaling59
Development G Proteins mediated regulation MARK ERK signaling59
Signal transduction IP3 signaling59
Development Angiotensin signaling via PYK259
Development EPO induced MAPK pathway59
9.8NOS3, PRKCE, ADORA2A, ADORA3
13
Show member pathways
9.6NOS3, PLA2G2A, PRKCE, PRKAA2, ADORA2A
14
Show member pathways
9.6SLC1A2, SLC1A6, SLC1A3, SLC1A7, SLC1A1
15
Show member pathways
9.6SLC1A1, SLC1A7, SLC1A3, SLC1A6, SLC1A2
16
Show member pathways
9.5SLC1A2, SLC1A6, SLC1A3, SLC1A7, SLC1A1, ADORA1

Compounds for genes affiliated with Ischemia

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Sources:
29IUPHAR, 44Novoseek, 25HMDB, 12DrugBank, 60Tocris Bioscience
See all sources

Compounds related to Ischemia according to GeneCards/GeneDecks:

(show top 50)    (show all 221)
idCompoundScoreTop Affiliating Genes
1apadenoson2910.4ADORA1, ADORA2A, ADORA3
2mrs51512910.4ADORA2A, ADORA1, ADORA3
3peneca2910.4ADORA2A, ADORA1, ADORA3
4psb-102910.4ADORA3, ADORA2A, ADORA1
5psb-112910.4ADORA2A, ADORA3, ADORA1
6(r,s)-phpneca2910.4ADORA2A, ADORA1, ADORA3
7dihydrokainate44 2911.4SLC1A2, SLC1A3, SLC1A1
8hemado2910.4ADORA3, ADORA2A, ADORA1
9las380962910.4ADORA2A, ADORA1, ADORA3
10fk-4532910.4ADORA2A, ADORA1, ADORA3
11mre 2029f202910.4ADORA2A, ADORA1, ADORA3
12psb6032910.3ADORA1, ADORA2A, ADORA3
13gs96672910.3ADORA2A, ADORA1, ADORA3
14(s)-pia2910.3ADORA3, ADORA1, ADORA2A
15n(6)-cyclohexyladenosine44 2911.3ADORA1, ADORA2A, ADK, ADORA3
16bay60-65832910.3ADORA2A, ADORA1, ADORA3
17adenosine29 25 1212.3ADK, ADORA1, ADORA2A, ADORA3
18slv3202910.3ADORA3, ADORA1, ADORA2A
195-diethoxyphosphoryl-5-methyl-1-pyrroline n-oxide4410.3SOD1, XDH, NOS3
20cgs 159432910.3ADORA3, ADORA1, ADORA2A
21sch44214162910.3ADORA3, ADORA1, ADORA2A
22sch 5826160 2911.2ADORA3, ADORA1, ADORA2A
23binodenoson44 2911.2ADORA3, ADORA1, ADORA2A
24regadenoson44 29 1212.2ADORA3, ADORA1, ADORA2A
25zm-2413852910.1ADORA2A, ADORA1, ADORA3
26theophylline44 29 25 1213.1ADORA3, ADORA1, ADORA2A, ADK, XDH
27tfb-tboa6010.1SLC1A7, SLC1A6, SLC1A2, SLC1A1, SLC1A3
28[3h]etb-tboa2910.1SLC1A2, SLC1A6, SLC1A3, SLC1A7, SLC1A1
29tcpa2910.1ADORA3, ADORA1, ADORA2A
30l-trans-2,4-pdc6010.1SLC1A1, SLC1A7, SLC1A3, SLC1A6, SLC1A2
31rolofylline2910.1ADORA3, ADORA1, ADORA2A
32[3h]d-aspartic acid2910.1SLC1A6, SLC1A1, SLC1A7, SLC1A3, SLC1A2
33[3h]l-aspartic acid2910.1SLC1A2, SLC1A6, SLC1A3, SLC1A7, SLC1A1
34way 2136136010.1SLC1A1, SLC1A7, SLC1A2, SLC1A6, SLC1A3
35dihydrokainic acid6010.0SLC1A1, SLC1A7, SLC1A3, SLC1A2, SLC1A6
36dl-tboa60 2911.0SLC1A1, SLC1A7, SLC1A3, SLC1A6, SLC1A2
37luf59812910.0ADORA3, ADORA1, ADORA2A
38l-glutamic acid29 25 1211.9SLC1A2, SLC1A3, SLC1A7, SLC1A1, SLC1A6
39xanthine44 2510.8XDH, SOD1, NOS3, ADK, ADORA3, ADORA1
40kainate44 2910.8ADORA1, HSPA4, ADK, ADORA2A, SLC1A1, SLC1A3
41mre 3008f20299.8ADORA3, ADORA1, ADORA2A
42aspartate449.5HSPA4, ADORA1, ADORA2A, CTSL, SLC1A1, SLC1A3
43adenylate449.5PRKAA2, PLA2G2A, SLC1A3, ADK, HSPA4, SLC1A2
44nitric oxide44 25 1211.4PRKAA2, NOS3, HSPA4, SLC1A3, SLC1A2, XDH
45oxygen44 2510.4HSPA4, ADK, SOD1, XDH, ADORA3, ADORA2A
46nmda44 2910.4ADORA1, ADK, HSPA4, PLA2G2A, SLC1A1, SLC1A7
47alanine449.4HSPA4, SOD1, ADORA1, PRKAA2, PLA2G2A, SLC1A2
48superoxide44 2510.2SOD1, ADORA3, PRKAA2, PLA2G2A, SLC1A2, XDH
49serine449.0PRKAA2, ADORA2A, SLC1A2, SLC1A3, CTSL, PLA2G2A
50glutamate448.4SLC1A2, HSPA4, SOD1, ADORA3, ADORA1, ADORA2A

GO Terms for genes affiliated with Ischemia

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Cellular components related to Ischemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1presynaptic active zoneGO:04878610.2ADORA2A, ADORA1
2axolemmaGO:03067310.2SLC1A2, ADORA2A, ADORA1
3asymmetric synapseGO:0322799.9ADORA2A, ADORA1
4neuronal cell bodyGO:0430259.8SOD1, ADORA1, ADORA2A, SLC1A3
5membraneGO:0160209.5YRDC, ADORA2A, SLC1A1, SLC1A3, SLC1A6, SLC1A2
6plasma membraneGO:0058868.7SOD1, ADORA3, ADORA1, ADORA2A, PRKCE, NOS3

Biological processes related to Ischemia according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of mucus secretionGO:07025710.4ADORA3, PRKCE
2relaxation of vascular smooth muscleGO:06008710.4ADORA1, SOD1
3D-aspartate importGO:07077910.4SLC1A2, SLC1A3, SLC1A1
4L-glutamate importGO:05193810.4SLC1A2, SLC1A3, SLC1A1
5response to woundingGO:00961110.3SLC1A2, SLC1A3, ADORA3
6positive regulation of synaptic transmission, GABAergicGO:03223010.3ADORA2A, PRKCE
7regulation of mitochondrial membrane potentialGO:05188110.2ADORA2A, SOD1
8L-glutamate transportGO:01581310.2SLC1A7, SLC1A6
9negative regulation of blood pressureGO:04577610.1NOS3, ADORA1
10regulation of excitatory postsynaptic membrane potentialGO:06007910.1ADORA2A, ADORA1
11response to drugGO:04249310.0SLC1A2, SLC1A3, ADORA2A, SOD1
12synaptic transmissionGO:00726810.0SLC1A1, SLC1A3, SLC1A6, SLC1A2
13ion transportGO:0068119.9SLC1A1, SLC1A7, SLC1A3, SLC1A6, SLC1A2
14transmembrane transportGO:0550859.8SLC1A1, SLC1A7, SLC1A3, SLC1A6, SLC1A2
15blood coagulationGO:0075969.8SOD1, ADORA2A, PRKCE, NOS3
16signal transductionGO:0071659.4SMOC2, ADORA3, ADORA1, PRKAA2, PRKCE

Molecular functions related to Ischemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutamate:sodium symporter activityGO:01550110.1SLC1A1, SLC1A2
2actin monomer bindingGO:00378510.1NOS3, PRKCE
3G-protein coupled adenosine receptor activityGO:00160910.1ADORA2A, ADORA1, ADORA3
4glutamate bindingGO:0165959.9SLC1A3, SLC1A1
5sodium:dicarboxylate symporter activityGO:0171539.7SLC1A2, SLC1A6, SLC1A3, SLC1A7, SLC1A1
6L-glutamate transmembrane transporter activityGO:0053139.7SLC1A1, SLC1A7, SLC1A3, SLC1A6, SLC1A2

Products for genes affiliated with Ischemia

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Sources for Ischemia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet