MCID: ISC004
MIFTS: 57

Ischemia malady

Summaries for Ischemia

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 In medicine, ischemia, also spelled as ischaemia or ischæmia, (/ɪˈskiːmɪə/;[a]) is a restriction... more...

MalaCards: Ischemia is related to brain ischemia and transient cerebral ischemia. An important gene associated with Ischemia is ADORA3 (adenosine A3 receptor), and among its related pathways are Circadian entrainment and Amino acid and oligopeptide SLC transporters. The compounds glutamate and superoxide have been mentioned in the context of this disorder. Related mouse phenotypes are homeostasis/metabolism and behavior/neurological.

Aliases & Classifications for Ischemia

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH
See all sources

Aliases & Descriptions:

ischemia 8 45 61


External Ids:

Disease Ontology8 DOID:326
NCIt40 C34738
SNOMED-CT57 52674009
MeSH35 D007511

Related Diseases for Ischemia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Ischemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 435)
idRelated DiseaseScoreTop Affiliating Genes
1brain ischemia31.8HSPA4, NOS3, ADORA1, ADORA3
2transient cerebral ischemia31.6HSPA4, PLA2G2A, ADORA1
3spinal cord ischemia31.6PLA2G2A
4coronary artery disease,30.7HSPA4, PLA2G2A, NOS3, ADORA1, ADORA2A
5coronary heart disease30.5HSPA4, XDH, PLA2G2A, NOS3
6vascular disease30.4SOD1, CTSL, XDH, NOS3
7atherosclerosis30.4HSPA4, SOD1, CTSL, PRKAA2, XDH, PLA2G2A
8hypercholesterolemia30.2NOS3, PLA2G2A, XDH
9alzheimer's disease30.1SOD1, CTSL, PLA2G2A, SLC1A2, SLC1A3, NOS3
10sepsis30.1ADORA2A, NOS3, PLA2G2A, XDH
11asthma30.0HSPA4, XDH, PLA2G2A, ADORA1, ADORA3, ADORA2A
12cadasil29.8HSPA4, PLA2G2A, SLC1A2, SLC1A3, NOS3, ADORA1
13insulin resistance29.8PRKAA2, PLA2G2A, NOS3, ADORA1
14colorectal cancer29.8PLA2G2A, XDH, CTSL
15type 2 diabetes mellitus29.6HSPA4, SOD1, PRKAA2, NOS3, ADORA1
16arthritis29.6ADORA3, PLA2G2A, CTSL
17septic shock29.6NOS3, PLA2G2A, XDH
18parkinson's disease29.6ADORA2A
19huntington's disease29.6ADORA2A, SLC1A2
20hepatopulmonary syndrome29.6NOS3
21critical limb ischemia11.1
22retinal ischemia11.0
23hypoxia10.9
24cerebral hypoxia10.8
25spinal cord injury10.7
26brain injury10.7
27cerebral artery occlusion10.6
28aortic aneurysm10.6
29brain edema10.5
30myocardial stunning10.5
31abdominal aortic aneurysm10.4
32carotid artery occlusion10.4
33acute myocardial infarction10.4
34memory impairment10.3
35angina pectoris10.3
36n syndrome10.3
37mesenteric artery ischemia10.3
38thoracic aortic aneurysm10.3
39peripheral vascular disease10.3
40anoxia10.3
41brain disease10.3
42ruptured abdominal aortic aneurysm10.2
43intermittent claudication10.2
44arteriosclerosis10.2
45moyamoya disease10.2
46thromboangiitis obliterans10.2
47transient global amnesia10.2
48carotid stenosis10.2
49hypertensive heart disease10.2
50hypoglycemia10.1

Graphical network of the top 20 diseases related to Ischemia:



Diseases related to ischemia

Clinical Features for Ischemia

Drugs & Therapeutics for Ischemia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Ischemia

Drug clinical trials:

Search ClinicalTrials for Ischemia

Search NIH Clinical Center for Ischemia

Search CenterWatch for Ischemia

Genetic Tests for Ischemia

Anatomical Context for Ischemia

Animal Models for Ischemia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Ischemia

Sources:
51PubMed
See all sources

Articles related to Ischemia:

(show top 50)    (show all 5374)
idTitleAuthorsYear
1
The small fibrinopeptide bI^15-42 as renoprotective agent preserving the endothelial and vascular integrity in early ischemia reperfusion injury in the mouse kidney. (24392138)
2014
2
Ionic transporter activity in astrocytes, microglia, and oligodendrocytes during brain ischemia. (23549380)
2013
3
Reduced beta-catenin expression in the hippocampal CA1 region following transient cerebral ischemia in the gerbil. (23504294)
2013
4
Modeling of diseases of retinal ischemia in vitro: possible participation of autocrine vascular endothelial growth factor signaling. (23257772)
2013
5
Sequential compression biomechanical device versus primary amputation in patients with critical limb ischemia. (24052447)
2013
6
Effects and mechanisms of chinese herbal medicine in ameliorating myocardial ischemia-reperfusion injury. (24288571)
2013
7
The influence of connective tissue disease in the management of lower limb ischemia. (24184498)
2013
8
Increasing Glutamate Promotes Ischemia-Reperfusion-Induced Ventricular Arrhythmias in Rats in vivo. (24401762)
2013
9
Effect of autologous adipose-derived stem cells in renal cold ischemia and reperfusion injury. (24182784)
2013
10
Regulator of calcineurin 1 (Rcan1) has a protective role in brain ischemia/reperfusion injury. (22397398)
2012
11
Diffusion tensor imaging detected optic nerve injury correlates with decreased compound action potentials after murine retinal ischemia. (22159023)
2012
12
Multilevel versus isolated endovascular tibial interventions for critical limb ischemia. (21803523)
2011
13
Postischemic administration of liposome-encapsulated luteolin prevents against ischemia-reperfusion injury in a rat middle cerebral artery occlusion model. (21190830)
2011
14
G-6-PD deficiency as the cause of isolated peripheral retinal ischemia. (21484659)
2011
15
Gender differences in serum and glucocorticoid regulated kinase-1 (SGK-1) expression during renal ischemia/reperfusion injury. (21691090)
2011
16
Influence of myocardial ischemia on outcomes in patients with systolic versus non-systolic heart failure. (22254196)
2011
17
Extended ischemia prevents HIF1alpha degradation at reoxygenation by impairing prolyl-hydroxylation: role of Krebs cycle metabolites. (20368331)
2010
18
Recurrent small bowel ischemia in a patient with paroxysmal nocturnal hemoglobinuria. (20440280)
2010
19
Delayed administration of glial cell line-derived neurotrophic factor (GDNF) protects retinal ganglion cells in a pig model of acute retinal ischemia. (19735654)
2009
20
Spinal cord ischemia after TEVAR in patients with abdominal aortic aneurysms. (19028067)
2009
21
Insulin activates the PI3K-Akt survival pathway in vulnerable neurons following global brain ischemia. (19203442)
2009
22
Geldanamycin protects rat brain through overexpression of HSP70 and reducing brain edema after cerebral focal ischemia. (18534054)
2008
23
Cerebral ischemia/stroke and small ubiquitin-like modifier (SUMO) conjugation--a new target for therapeutic intervention? (18410505)
2008
24
Technology insight: can neuroimaging provide insights into the role of ischemia in BalA^'s concentric sclerosis? (17549060)
2007
25
Enhanced protection of modified human acidic fibroblast growth factor with polyethylene glycol against ischemia/reperfusion-induced retinal damage in rats. (17416472)
2007
26
FLIP(L) protects neurons against in vivo ischemia and in vitro glucose deprivation-induced cell death. (17581950)
2007
27
Impact of preoperative steroids administration on ischemia-reperfusion injury and systemic responses in liver surgery: a prospective randomized study. (16710858)
2006
28
Proteasome inhibition attenuates lung injury induced by intestinal ischemia reperfusion in rats. (16875703)
2006
29
Role of oxidative/nitrosative stress in the tolerance to ischemia/reperfusion injury in cardiomyopathic hamster heart. (16910782)
2006
30
CXCR2/CXCR2 ligand biology during lung transplant ischemia-reperfusion injury. (16272353)
2005
31
Molecular changes in nNOS protein expression within the ventrolateral medulla following transient focal ischemia affect cardiovascular functions. (16084499)
2005
32
Bosentan, the mixed ETA-ETB endothelin receptor antagonist, attenuated oxidative stress after experimental myocardial ischemia and reperfusion. (16335785)
2005
33
PI3K rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injury. (16007268)
2005
34
Heme oxygenase-1: a pluripotent sentinel limiting the systemic inflammatory response to extremity ischemia and reperfusion. (16276211)
2005
35
Synthetic high-density lipoproteins exert cardioprotective effects in myocardial ischemia/reperfusion injury. (14566009)
2004
36
Acute changes in circulating natriuretic peptide levels in relation to myocardial ischemia. (15542281)
2004
37
Protective effect of D-003 on experimental spinal cord ischemia in rabbits. (14643173)
2004
38
Steady plasma concentration of unfractionated heparin reduces infarct volume and prevents inflammatory damage after transient focal cerebral ischemia in the rat. (15264226)
2004
39
The role of endothelin-1 in hepatic ischemia and reperfusion injury. (12375155)
2002
40
Cold blood spinal cord plegia for prediction of spinal cord ischemia during thoracoabdominal aneurysm repair. (11996256)
2002
41
Therapeutic angiogenesis induced by human hepatocyte growth factor gene in rat and rabbit hindlimb ischemia models: preclinical study for treatment of peripheral arterial disease. (11313789)
2001
42
Blood partition and protein binding of a new neuroprotective agent for ischemia-reperfusion damage, KR-31378. (12889527)
2001
43
Maximum length sequence brainstem auditory evoked responses in term neonates who have perinatal hypoxia-ischemia. (11044485)
2000
44
Pro- and anti-inflammatory cytokine-response in abdominal aortic aneurysm repair: a clinical model of ischemia-reperfusion. (10353534)
1999
45
Generation of superoxide in cardiomyocytes during ischemia before reperfusion. (10600842)
1999
46
Three different approaches to spinal cord monitoring for the prediction of spinal cord ischemia during thoracic aortic aneurysm surgery. (9828291)
1998
47
Role of kinins in the pathophysiology of myocardial ischemia. In vitro and in vivo studies. (8529801)
1996
48
Suppression of ischemia-induced fos expression and AP-1 activity by an antisense oligodeoxynucleotide to c-fos mRNA. (7944289)
1994
49
Changes of [3H]cyclic adenosine monophosphate binding in the gerbil brain following transient cerebral ischemia: an autoradiographic study and investigation of the effects of vinconate and pentobarbital. (8383351)
1993
50
Colonic ischemia complicating immunotherapy with interleukin-2 and interferon-alpha. (1893354)
1991

Genetic Variations for Ischemia

Expression for genes affiliated with Ischemia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Ischemia

Search GEO for disease gene expression data for Ischemia.

Pathways for genes affiliated with Ischemia

Sources:
30KEGG, 54Reactome, 4Cell Signaling Technology, 52QIAGEN, 12EMD Millipore, 38NCBI BioSystems Database, 50PharmGKB
See all sources

Pathways related to Ischemia according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.5SLC1A2, ADORA1, SLC1A3, SLC1A6, SLC1A1, SLC1A7
2
Hide members
11.3SLC1A7, SLC1A2, SLC1A6, SLC1A3, SLC1A1
3
Hide members
11.3SLC1A7, SLC1A2, SLC1A1, SLC1A6, SLC1A3
4
Hide members
11.3SLC1A3, SLC1A6, SLC1A1, SLC1A2, SLC1A7
511.2SOD1, SLC1A2, SLC1A1, SLC1A3
6
Hide members
11.2SLC1A3, SLC1A1, SOD1, SLC1A2
711.0SLC1A1, SLC1A3, SLC1A2
8
Hide members
11.0ADORA3, ADORA1, ADORA2A
911.0SLC1A1, SLC1A2, SOD1
10
Signal transduction IP3 signaling
Hide members
11.0ADORA3, ADORA2A, PRKCE
11
Development A3 receptor signaling
Hide members
11.0PRKCE, ADORA1, ADORA3
12
Development A2B receptor- action via G-protein alpha s
Hide members
11.0NOS3, ADORA2A, PRKCE
13
Hide members
11.0NOS3, XDH, SOD1
14
Hide members
11.0SLC1A7, SLC1A1, SLC1A6
15
Hide members
11.0SLC1A7, SLC1A1, SLC1A6
16
CFTR folding and maturation (norm and CF)
11.0NOS3, SOD1, HSPA4
17
Hide members
10.8SLC1A2, SLC1A3

Compounds for genes affiliated with Ischemia

Sources:
45Novoseek, 24HMDB, 11DrugBank, 29IUPHAR, 60Tocris Bioscience
See all sources

Compounds related to Ischemia according to GeneCards/GeneDecks:

(show top 50)    (show all 200)
idCompoundScoreTop Affiliating Genes
1glutamate4513.4HSPA4, ADORA3, ADORA1, NOS3, SLC1A3, SLC1A6
2superoxide45 2413.6SLC1A2, PLA2G2A, XDH, PRKAA2, CTSL, SOD1
3adenylate4512.5PLA2G2A, ADORA2A, ADORA3, ADORA1, ADK, SLC1A3
4nitric oxide45 11 2414.5SOD1, PRKAA2, XDH, SLC1A2, SLC1A3, NOS3
5alanine4512.4ADORA1, SLC1A1, SLC1A3, SLC1A2, PLA2G2A, PRKAA2
6nmda45 2913.3ADK, HSPA4, SLC1A7, SLC1A2, SLC1A1, SLC1A3
7aspartate4512.3HSPA4, SLC1A3, CTSL, SLC1A2, SLC1A1, SLC1A6
8xanthine45 2413.1SOD1, ADORA1, XDH, NOS3, ADK, ADORA2A
9kainate45 2913.1HSPA4, ADK, ADORA2A, ADORA1, SLC1A3, SLC1A1
10serine4511.9SLC1A3, SLC1A2, PLA2G2A, PRKCE, PRKAA2, CTSL
11tfb-tboa6011.8SLC1A3, SLC1A7, SLC1A1, SLC1A2, SLC1A6
12dl-tboa60 2912.8SLC1A6, SLC1A3, SLC1A1, SLC1A7, SLC1A2
13[3h]d-aspartic acid2911.8SLC1A7, SLC1A3, SLC1A6, SLC1A1, SLC1A2
14way 2136136011.8SLC1A3, SLC1A6, SLC1A1, SLC1A2, SLC1A7
15dihydrokainic acid6011.8SLC1A7, SLC1A2, SLC1A1, SLC1A6, SLC1A3
16l-trans-2,4-pdc6011.8SLC1A3, SLC1A7, SLC1A2, SLC1A1, SLC1A6
17[3h]l-aspartic acid2911.8SLC1A3, SLC1A6, SLC1A1, SLC1A2, SLC1A7
18[3h]etb-tboa2911.8SLC1A7, SLC1A1, SLC1A2, SLC1A3, SLC1A6
19theophylline45 29 11 2414.7ADORA3, ADORA1, XDH, ADK, ADORA2A
20n(6)-cyclohexyladenosine45 2912.6ADORA2A, ADORA3, ADORA1, ADK
21adenosine29 11 2413.6ADK, ADORA1, ADORA3, ADORA2A
22mrs51512911.4ADORA2A, ADORA1, ADORA3
23psb-102911.4ADORA1, ADORA3, ADORA2A
24apadenoson2911.4ADORA2A, ADORA3, ADORA1
25psb-112911.4ADORA3, ADORA2A, ADORA1
26dihydrokainate45 2912.4SLC1A2, SLC1A3, SLC1A1
275-diethoxyphosphoryl-5-methyl-1-pyrroline n-oxide4511.4NOS3, XDH, SOD1
28peneca2911.4ADORA2A, ADORA3, ADORA1
29(r,s)-phpneca2911.4ADORA2A, ADORA3, ADORA1
30biib0142911.3ADORA2A, ADORA3, ADORA1
31xac2911.3ADORA1, ADORA3, ADORA2A
328-(p-sulfophenyl)theophylline4511.3ADORA2A, ADORA3, ADORA1
33preladenant2911.3ADORA2A, ADORA1, ADORA3
34tcpa2911.3ADORA2A, ADORA3, ADORA1
35sch 5826160 2912.3ADORA2A, ADORA3, ADORA1
36cgs 159432911.3ADORA2A, ADORA3, ADORA1
37zm-2413852911.3ADORA2A, ADORA3, ADORA1
38mrs17542911.3ADORA3, ADORA2A, ADORA1
39(s)-pia2911.2ADORA1, ADORA3, ADORA2A
40tonapofylline2911.2ADORA1, ADORA3, ADORA2A
41(r)-pia2911.2ADORA2A, ADORA3, ADORA1
42cyclopentyladenosine2911.2ADORA1, ADORA3, ADORA2A
43atl8022911.2ADORA1, ADORA3, ADORA2A
44sch44214162911.1ADORA2A, ADORA3
45psb6032911.1ADORA2A, ADORA3, ADORA1
46slv3202911.1ADORA2A, ADORA3, ADORA1
47kf267772911.0ADORA2A, ADORA3, ADORA1
48gs96672911.0ADORA1, ADORA3, ADORA2A
49ib-meca29 6011.9ADORA2A, ADORA3, ADORA1
50bay60-65832910.7ADORA1, ADORA3, ADORA2A

GO Terms for genes affiliated with Ischemia

Sources:
16Gene Ontology
See all sources

Cellular components related to Ischemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588612.5SOD1, PRKCE, SLC1A7, SLC1A2, SLC1A1, SLC1A6
2membraneGO:01602011.5YRDC, SLC1A2, SLC1A1, SLC1A6, SLC1A3, ADORA2A
3axolemmaGO:03067311.1ADORA2A, ADORA1, SLC1A2
4neuronal cell bodyGO:04302510.9SOD1, SLC1A3, ADORA1, ADORA2A
5presynaptic active zoneGO:04878610.8ADORA2A, ADORA1
6asymmetric synapseGO:03227910.7ADORA2A, ADORA1

Biological processes related to Ischemia according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1ion transportGO:00681111.6SLC1A7, SLC1A2, SLC1A1, SLC1A6, SLC1A3
2transmembrane transportGO:05508511.2SLC1A7, SLC1A2, SLC1A1, SLC1A6, SLC1A3
3D-aspartate importGO:07077911.2SLC1A3, SLC1A1, SLC1A2
4L-glutamate importGO:05193811.2SLC1A3, SLC1A1, SLC1A2
5response to woundingGO:00961111.2ADORA3, SLC1A3, SLC1A2
6positive regulation of mucus secretionGO:07025711.0ADORA3, PRKCE
7relaxation of vascular smooth muscleGO:06008710.9SOD1, ADORA1
8L-glutamate transportGO:01581310.9SLC1A6, SLC1A7
9response to drugGO:04249310.9ADORA2A, SLC1A3, SLC1A2, SOD1
10positive regulation of synaptic transmission, GABAergicGO:03223010.8ADORA2A, PRKCE
11regulation of mitochondrial membrane potentialGO:05188110.8ADORA2A, SOD1

Molecular functions related to Ischemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sodium:dicarboxylate symporter activityGO:01715311.5SLC1A3, SLC1A6, SLC1A1, SLC1A2, SLC1A7
2L-glutamate transmembrane transporter activityGO:00531311.4SLC1A7, SLC1A2, SLC1A1, SLC1A6, SLC1A3
3G-protein coupled adenosine receptor activityGO:00160911.0ADORA2A, ADORA3, ADORA1
4actin monomer bindingGO:00378510.8NOS3, PRKCE
5glutamate:sodium symporter activityGO:01550110.7SLC1A2, SLC1A1
6glutamate bindingGO:01659510.5SLC1A3, SLC1A1

Products for genes affiliated with Ischemia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Ischemia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet