MCID: ISC005
MIFTS: 30

Ischemic Bone Disease

Categories: Bone diseases

Aliases & Classifications for Ischemic Bone Disease

MalaCards integrated aliases for Ischemic Bone Disease:

Name: Ischemic Bone Disease 12 14

Classifications:



External Ids:

Disease Ontology 12 DOID:0080008

Summaries for Ischemic Bone Disease

Disease Ontology : 12 A bone disease that results_in an interruption of blood supply located in bone.

MalaCards based summary : Ischemic Bone Disease is related to osteochondrosis and cohen-gibson syndrome. An important gene associated with Ischemic Bone Disease is TBXAS1 (Thromboxane A Synthase 1), and among its related pathways/superpathways are RANK Signaling in Osteoclasts and G-protein signaling Ras family GTPases in kinase cascades (scheme). Affiliated tissues include bone, bone and bone marrow, and related phenotypes are growth/size/body region and cardiovascular system

Related Diseases for Ischemic Bone Disease

Diseases related to Ischemic Bone Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Related Disease Score Top Affiliating Genes
1 osteochondrosis 31.6 COL2A1 KLHDC2 TBXAS1
2 cohen-gibson syndrome 29.6 BGLAP TNFRSF11A TNFRSF11B TNFSF11
3 osteonecrosis 29.0 ACP5 BGLAP BMP2 COL2A1 F2 PTH
4 dysbaric osteonecrosis 11.0
5 osteochondritis dissecans 10.9
6 osteopetrosis, autosomal dominant 2 10.5 BGLAP TNFSF11
7 axial osteomalacia 10.5 BGLAP PTH
8 multicentric reticulohistiocytosis 10.5 TNFRSF11B TNFSF11
9 pseudoarthrosis 10.5 BMP2 PTH
10 kummell's disease 10.5 TNFRSF11B TNFSF11
11 extraskeletal chondroma 10.4 BGLAP PTH
12 tooth ankylosis 10.4 BMP2 TNFSF11
13 villonodular synovitis 10.4 ACP5 TNFSF11
14 periodontitis, chronic 10.4 TNFRSF11B TNFSF11
15 chronic apical periodontitis 10.4 TNFRSF11B TNFSF11
16 breast leiomyosarcoma 10.4 TNFRSF11A TNFSF11
17 ossification of the posterior longitudinal ligament of spine 10.4 BGLAP BMP2 RUNX2
18 fibrogenesis imperfecta ossium 10.4 PTH TNFRSF11B
19 osseous heteroplasia, progressive 10.4 BGLAP BMP2 RUNX2
20 synovial chondromatosis 10.4 BMP2 COL2A1 RUNX2
21 achondrogenesis, type ia 10.4 ACAN COL2A1
22 endosteal hyperostosis, autosomal dominant 10.4 BMP2 TNFRSF11B TNFSF11
23 spondyloarthropathy 1 10.4 BGLAP TNFRSF11B TNFSF11
24 osteomyelitis 10.4 ACP5 BMP2 TNFSF11
25 aortic valve disease 1 10.4 BMP2 RUNX2 TNFRSF11B
26 bone deterioration disease 10.3 ACAN BMP2 COL2A1
27 bone structure disease 10.3 ACAN BMP2 COL2A1
28 periodontitis 10.3 BGLAP TNFRSF11B TNFSF11
29 adamantinoma of long bones 10.3 BGLAP SP7 TNFSF11
30 brachydactyly 10.3 BMP2 COL2A1 RUNX2
31 alveolar periostitis 10.3 BGLAP RUNX2
32 renal osteodystrophy 10.3 BGLAP PTH TNFRSF11B
33 polyarticular onset juvenile idiopathic arthritis 10.3 TNFRSF11A TNFRSF11B TNFSF11
34 hemophilic arthropathy 10.3 TNFRSF11A TNFRSF11B TNFSF11
35 paget disease of bone 5, juvenile-onset 10.3 TNFRSF11A TNFRSF11B TNFSF11
36 familial expansile osteolysis 10.3 TNFRSF11A TNFRSF11B TNFSF11
37 arthropathy 10.3 ACAN TNFRSF11B TNFSF11
38 differentiated thyroid carcinoma 10.3 BGLAP TNFRSF11B VEGFA
39 osteochondrodysplasia 10.2 BGLAP COL2A1 SP7
40 aortic valve disease 2 10.2 BMP2 RUNX2 TNFRSF11B TNFSF11
41 periostitis 10.2 TNFRSF11A TNFRSF11B
42 osteitis fibrosa 10.2 BGLAP PTH
43 myeloma, multiple 10.1 TNFRSF11B TNFSF11 VEGFA
44 osteoarthritis 10.1 ACAN COL2A1 TNFRSF11B TNFSF11
45 livedoid vasculopathy 10.1 F2 SERPINE1
46 multicentric carpotarsal osteolysis syndrome 10.1 BGLAP TNFRSF11A TNFRSF11B TNFSF11
47 secondary hyperparathyroidism of renal origin 10.1 ACP5 BGLAP PTH TNFRSF11B
48 giant cell tumor 10.1 BGLAP TNFRSF11A TNFRSF11B TNFSF11
49 root resorption 10.1 RUNX2 TNFRSF11A TNFRSF11B TNFSF11
50 periodontal disease 10.1 TNFRSF11A TNFRSF11B TNFSF11

Graphical network of the top 20 diseases related to Ischemic Bone Disease:



Diseases related to Ischemic Bone Disease

Symptoms & Phenotypes for Ischemic Bone Disease

MGI Mouse Phenotypes related to Ischemic Bone Disease:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.14 RUNX2 F2 SERPINE1 KLHDC2 BMP2 PTH
2 cardiovascular system MP:0005385 10.11 COL2A1 RUNX2 F2 SERPINE1 KLHDC2 BMP2
3 hematopoietic system MP:0005397 10.11 F2 SERPINE1 KLHDC2 BMP2 PTH RUNX2
4 immune system MP:0005387 10.1 F2 SERPINE1 KLHDC2 BMP2 PTH COL2A1
5 craniofacial MP:0005382 10.09 KLHDC2 BMP2 PTH COL2A1 RUNX2 TNFRSF11B
6 mortality/aging MP:0010768 9.93 F2 SERPINE1 KLHDC2 SP7 BMP2 PTH
7 limbs/digits/tail MP:0005371 9.91 SP7 BMP2 PTH COL2A1 RUNX2 TNFRSF11B
8 respiratory system MP:0005388 9.56 F2 SERPINE1 SP7 COL2A1 RUNX2 TNFRSF11A
9 skeleton MP:0005390 9.32 F2 SP7 BMP2 PTH COL2A1 RUNX2

Drugs & Therapeutics for Ischemic Bone Disease

Search Clinical Trials , NIH Clinical Center for Ischemic Bone Disease

Genetic Tests for Ischemic Bone Disease

Anatomical Context for Ischemic Bone Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Ischemic Bone Disease:

18
Bone

MalaCards organs/tissues related to Ischemic Bone Disease:

38
Bone, Bone Marrow

Publications for Ischemic Bone Disease

Articles related to Ischemic Bone Disease:

# Title Authors Year
1
Bone marrow edema: mild or nascent variant of ischemic bone disease. ( 18083442 )
2008

Variations for Ischemic Bone Disease

Expression for Ischemic Bone Disease

Search GEO for disease gene expression data for Ischemic Bone Disease.

Pathways for Ischemic Bone Disease

Pathways related to Ischemic Bone Disease according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.16 ACP5 TNFRSF11A TNFRSF11B TNFSF11
2
Show member pathways
12.03 SERPINE1 TNFRSF11A TNFSF11 VEGFA
3 11.84 ACP5 TNFRSF11A TNFRSF11B TNFSF11
4 11.66 ACP5 TNFRSF11A TNFSF11 VEGFA
5
Show member pathways
11.58 TNFRSF11A TNFRSF11B TNFSF11
6 11.53 ACAN COL2A1 PTH RUNX2 VEGFA
7 11.26 BGLAP PTH RUNX2 TNFSF11
8 11.15 ACAN BGLAP BMP2 COL2A1 PTH RUNX2
9 11.09 BGLAP PTH RUNX2 TNFRSF11A TNFRSF11B TNFSF11
10 10.76 ACP5 TNFRSF11A TNFRSF11B TNFSF11
11 10.69 BGLAP F2
12 10.6 BGLAP PTH TNFRSF11B TNFSF11

GO Terms for Ischemic Bone Disease

Cellular components related to Ischemic Bone Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 ACAN BGLAP BMP2 COL2A1 EGFL8 F2
2 proteinaceous extracellular matrix GO:0005578 9.56 ACAN COL2A1 TNFRSF11B VEGFA
3 Golgi lumen GO:0005796 9.33 ACAN BGLAP F2
4 extracellular space GO:0005615 9.32 ACAN BGLAP BMP2 COL2A1 F2 PTH

Biological processes related to Ischemic Bone Disease according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.84 ACAN COL2A1 SERPINE1 TNFRSF11B
2 response to ethanol GO:0045471 9.8 BGLAP PTH TBXAS1
3 regulation of receptor activity GO:0010469 9.7 BMP2 F2 PTH SERPINE1 TNFRSF11B TNFSF11
4 osteoblast differentiation GO:0001649 9.67 BGLAP BMP2 RUNX2 SP7
5 chondrocyte differentiation GO:0002062 9.65 BMP2 COL2A1 RUNX2
6 response to vitamin D GO:0033280 9.63 BGLAP PTH
7 signal peptide processing GO:0006465 9.63 BGLAP F2
8 cellular response to BMP stimulus GO:0071773 9.63 BMP2 COL2A1 RUNX2
9 osteoblast development GO:0002076 9.62 BGLAP RUNX2
10 chondrocyte development GO:0002063 9.61 ACAN RUNX2
11 regulation of osteoclast differentiation GO:0045670 9.61 BGLAP TNFSF11
12 positive regulation of ossification GO:0045778 9.6 BMP2 PTH
13 response to inorganic substance GO:0010035 9.59 BGLAP TNFRSF11B
14 positive regulation of blood coagulation GO:0030194 9.58 F2 SERPINE1
15 peptidyl-glutamic acid carboxylation GO:0017187 9.58 BGLAP F2
16 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus GO:1901522 9.57 BMP2 RUNX2
17 negative regulation of fibrinolysis GO:0051918 9.56 F2 SERPINE1
18 proteoglycan metabolic process GO:0006029 9.55 BMP2 COL2A1
19 regulation of odontogenesis of dentin-containing tooth GO:0042487 9.52 BMP2 RUNX2
20 bone resorption GO:0045453 9.5 ACP5 PTH TNFSF11
21 TNFSF11-mediated signaling pathway GO:0071847 9.49 TNFRSF11A TNFSF11
22 positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 9.43 TNFRSF11A TNFSF11
23 mammary gland alveolus development GO:0060749 9.43 TNFRSF11A TNFSF11 VEGFA
24 ossification GO:0001503 9.43 BGLAP BMP2 COL2A1 RUNX2 TNFRSF11A TNFSF11
25 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848 9.4 TNFRSF11A TNFSF11
26 skeletal system development GO:0001501 9.17 ACAN BGLAP BMP2 COL2A1 PTH RUNX2
27 positive regulation of transcription by RNA polymerase II GO:0045944 10.05 BMP2 PTH RUNX2 SERPINE1 SP7 TNFSF11

Molecular functions related to Ischemic Bone Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 BMP2 TNFRSF11B TNFSF11 VEGFA

Sources for Ischemic Bone Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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