MCID: ISC005
MIFTS: 35

Ischemic Bone Disease

Categories: Bone diseases

Aliases & Classifications for Ischemic Bone Disease

MalaCards integrated aliases for Ischemic Bone Disease:

Name: Ischemic Bone Disease 12 14

Classifications:



External Ids:

Disease Ontology 12 DOID:0080008

Summaries for Ischemic Bone Disease

Disease Ontology : 12 A bone disease that results_in an interruption of blood supply located in bone.

MalaCards based summary : Ischemic Bone Disease is related to osteochondrosis and osteochondritis dissecans. An important gene associated with Ischemic Bone Disease is TBXAS1 (Thromboxane A Synthase 1), and among its related pathways/superpathways are RANK Signaling in Osteoclasts and Osteoclast differentiation. The drugs Alendronate and Menthol have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and heart, and related phenotypes are growth/size/body region and cardiovascular system

Related Diseases for Ischemic Bone Disease

Diseases related to Ischemic Bone Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 72)
id Related Disease Score Top Affiliating Genes
1 osteochondrosis 31.5 ACAN COL2A1 TNFRSF11B TNFSF11
2 osteochondritis dissecans 10.8
3 osteonecrosis 10.8
4 dysbaric osteonecrosis 10.8
5 binocular vision disease 10.8 BMP2 TNFSF11
6 familial mediterranean fever, ar 10.8 BGLAP TNFSF11
7 larynx leiomyosarcoma 10.7 TNFRSF11A TNFSF11
8 cortical blindness 10.7 TNFRSF11B TNFSF11
9 achondrogenesis 10.7 BGLAP PTH
10 photoallergic dermatitis 10.6 BGLAP PTH
11 internal hordeolum 10.6 ACP5 TNFSF11
12 peripheral scars of retina 10.6 TNFRSF11B TNFSF11
13 ectopic cushing syndrome 10.6 BGLAP BMP2 RUNX2
14 acth-independent macronodular adrenal hyperplasia 10.6 BGLAP BMP2 RUNX2
15 hypochondrogenesis 10.6 PTH TNFRSF11B
16 syringobulbia 10.6 BMP2 COL2A1 RUNX2
17 van buchem disease, type 2 10.6 BMP2 TNFRSF11B TNFSF11
18 white sponge nevus of cannon, krt4-related 10.6 BGLAP PTH
19 psoriasis susceptibility 1 10.6 BGLAP TNFRSF11B TNFSF11
20 leber congenital amaurosis 3 10.5 ACAN COL2A1
21 pleomorphic lipoma 10.5 ACP5 BMP2 TNFSF11
22 vaginal carcinosarcoma 10.5 BGLAP RUNX2
23 adams-oliver syndrome 5 10.5 BMP2 RUNX2 TNFRSF11B
24 polyembryoma 10.5 TNFRSF11A TNFRSF11B TNFSF11
25 vulva fibroepithelial polyp 10.5 BGLAP TNFRSF11B TNFSF11
26 bone structure disease 10.5 ACAN BMP2 COL2A1
27 tibial hemimelia 10.5 TNFRSF11A TNFRSF11B TNFSF11
28 paget disease of bone 2, early-onset 10.5 TNFRSF11A TNFRSF11B TNFSF11
29 hennekam van der horst syndrome 10.5 TNFRSF11A TNFRSF11B TNFSF11
30 chromosomal disease 10.5 ACAN BMP2 COL2A1
31 mixed cell type adenoma of parathyroid 10.5 BGLAP PTH
32 carotenemia 10.4 TNFRSF11A TNFRSF11B
33 non-distal trisomy 10q 10.4 BGLAP TNFRSF11B VEGFA
34 tinea unguium 10.4 BGLAP PTH TNFRSF11B
35 glossopharyngeal nerve paralysis 10.4 ACAN TNFRSF11B TNFSF11
36 craniosynostosis 7 10.4 BMP2 RUNX2 TNFRSF11B TNFSF11
37 hyperparathyroidism, familial primary 10.4 ACP5 BGLAP PTH
38 pharyngitis 10.4 BGLAP BMP2 RUNX2 TNFRSF11B
39 cerebral hemorrhage 10.4 ACAN COL2A1
40 osteopetrosis 10.3 COL2A1 KLHDC2 TBXAS1
41 lockwood feingold syndrome 10.3 F2 SERPINE1
42 hypersensitivity vasculitis 10.3 COL2A1 VEGFA
43 spinocerebellar ataxia 4 10.3 BGLAP TNFRSF11A TNFRSF11B TNFSF11
44 preretinal fibrosis 10.3 BGLAP TNFRSF11A TNFRSF11B TNFSF11
45 glossitis 10.3 RUNX2 TNFRSF11A TNFRSF11B TNFSF11
46 inappropriate adh syndrome 10.2 TNFRSF11A TNFRSF11B TNFSF11
47 metaphyseal anadysplasia 2 10.2 ACP5 TNFRSF11A TNFRSF11B TNFSF11
48 lower clivus meningioma 10.2 ACP5 TNFRSF11A TNFRSF11B TNFSF11
49 pes anserinus tendinitis or bursitis 10.2 ACP5 BGLAP PTH TNFRSF11B
50 xanthomatosis 10.2 BGLAP PTH

Graphical network of the top 20 diseases related to Ischemic Bone Disease:



Diseases related to Ischemic Bone Disease

Symptoms & Phenotypes for Ischemic Bone Disease

MGI Mouse Phenotypes related to Ischemic Bone Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.11 TNFSF11 VEGFA BMP2 COL2A1 F2 KLHDC2
2 cardiovascular system MP:0005385 10.09 VEGFA BMP2 COL2A1 F2 KLHDC2 PTH
3 craniofacial MP:0005382 10.06 BMP2 COL2A1 KLHDC2 PTH RUNX2 TNFRSF11A
4 hematopoietic system MP:0005397 10.02 BMP2 F2 PTH RUNX2 SERPINE1 TBXAS1
5 immune system MP:0005387 10 BMP2 COL2A1 F2 PTH RUNX2 SERPINE1
6 limbs/digits/tail MP:0005371 9.76 BMP2 COL2A1 PTH RUNX2 TNFRSF11A TNFRSF11B
7 respiratory system MP:0005388 9.5 COL2A1 F2 RUNX2 SERPINE1 TNFRSF11A TNFSF11
8 skeleton MP:0005390 9.28 TNFSF11 VEGFA BMP2 COL2A1 F2 PTH

Drugs & Therapeutics for Ischemic Bone Disease

Drugs for Ischemic Bone Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 107)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Alendronate Approved Phase 4 121268-17-5, 66376-36-1 2088
2
Menthol Approved Phase 4 2216-51-5 16666
3 Bone Density Conservation Agents Phase 4,Phase 3
4 Calcium, Dietary Phase 4,Phase 3
5
Minocycline Approved, Investigational Phase 2, Phase 3 10118-90-8 5281021
6
Progesterone Approved, Vet_approved Phase 3 57-83-0 5994
7
Tamoxifen Approved Phase 3 10540-29-1 2733526
8
Midazolam Approved, Illicit Phase 2, Phase 3,Phase 1 59467-70-8 4192
9
Lenograstim Approved Phase 2, Phase 3,Phase 1 135968-09-1
10
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 2, Phase 3,Phase 1 437-38-7 3345
11
Medroxyprogesterone acetate Approved, Investigational Phase 3 71-58-9
12 Defibrotide Approved, Investigational Phase 3 83712-60-1
13
Vitamin D Approved, Nutraceutical, Vet_approved Phase 3 1406-16-2
14
Ergocalciferol Approved, Nutraceutical Phase 3 50-14-6 5280793
15
Caffeine Approved, Nutraceutical Phase 3 58-08-2 2519
16 Micronutrients Phase 3
17 Anesthetics Phase 3,Phase 2,Phase 1
18 Trace Elements Phase 3
19 Anti-Bacterial Agents Phase 2, Phase 3
20 Ergocalciferols Phase 3
21 Pharmaceutical Solutions Phase 2, Phase 3,Phase 1
22 Vitamins Phase 3
23 Anti-Infective Agents Phase 2, Phase 3
24 Progestins Phase 3
25
Medroxyprogesterone Phase 3 520-85-4 10631
26 Ibandronic acid Phase 3
27 Fibrinolytic Agents Phase 3
28 Adjuvants, Immunologic Phase 2, Phase 3,Phase 1
29 Selective Estrogen Receptor Modulators Phase 3
30 Coagulants Phase 3
31 Contraceptive Agents Phase 3
32 Contraceptive Agents, Male Phase 3
33 Contraceptives, Oral Phase 3
34 Hormone Antagonists Phase 3,Phase 2
35 Hormones Phase 3,Phase 2
36 Diphosphonates Phase 3
37 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
38 Estrogen Antagonists Phase 3
39 Estrogen Receptor Modulators Phase 3
40 Estrogens Phase 3,Phase 2
41 Estrogens, Conjugated (USP) Phase 3
42 Phytoestrogens Phase 3,Phase 2
43 Platelet Aggregation Inhibitors Phase 3
44 Anticoagulants Phase 3
45 Anti-Inflammatory Agents Phase 3,Phase 1
46 Antineoplastic Agents, Hormonal Phase 3
47 Immunoglobulins Phase 3
48 Antibodies Phase 3
49 Calcifediol Phase 3 19356-17-3
50 Hydroxycholecalciferols Phase 3

Interventional clinical trials:

(show top 50) (show all 192)

id Name Status NCT ID Phase Drugs
1 Study of the Effect of Alendronate on Vascular Calcification and Arterial Stiffness in Chronic Kidney Disease Completed NCT00395382 Phase 4 Alendronate;Placebo
2 Transepicardial With Transseptal Autologous CD 133+ Bone Marrow Cell Implantation in Patient Following CABG Surgery Recruiting NCT02870933 Phase 4
3 Clinical Evaluation of Magnetic Resonance Imaging in Coronary Heart Disease-2 Active, not recruiting NCT01664858 Phase 4
4 Cell Therapy in Severe Chronic Ischemic Heart Disease Unknown status NCT01727063 Phase 2, Phase 3
5 Autologous Bone Marrow-derived Mononuclear Cells for Therapeutic Arteriogenesis in Patients With Limb Ischemia Unknown status NCT00539266 Phase 2, Phase 3
6 Autologous Bone Marrow Stem Cell Transplantation for Critical, Limb-threatening Ischemia Unknown status NCT00434616 Phase 2, Phase 3
7 Prevention of Imminent Paralysis Following Spinal Cord Trauma or Ischemia by Minocycline: A Multi-center Study in Israel With IDF Primary Care Involvement Unknown status NCT01813240 Phase 2, Phase 3 Minocycline;placebo
8 Safety and Efficacy of Autologous Cardiopoietic Cells for Treatment of Ischemic Heart Failure. Unknown status NCT01768702 Phase 3
9 Clinical Trial of Kryptonite for Prevention of Sternal Complications in High Risk Patients Undergoing Cardiac Surgery Unknown status NCT01368991 Phase 3
10 Bone Marrow Aspirate Concentrate (BMAC) for Treatment of Critical Limb Ischemia (CLI) Completed NCT01245335 Phase 3
11 Bone Marrow Derived Adult Stem Cells for Chronic Heart Failure Completed NCT00747708 Phase 2, Phase 3 Granulocyte-colony stimulating factor
12 Bone Marrow Autograft in Limb Ischemia Completed NCT00904501 Phase 3
13 Women's Health Initiative (WHI) Completed NCT00000611 Phase 3 hormone replacement therapy;estrogens;progestins;estrogen replacement therapy;calcium;vitamin D
14 Postmenopausal Estrogen/Progestin Interventions (PEPI) Completed NCT00000466 Phase 3 estrogens, conjugated;medroxyprogesterone;progesterone;estrogen replacement therapy
15 Study Into the Effect of Ibandronate for the Treatment of Bone Marrow Edema in Relation to Spontaneous or Non-traumatic Osteonecrosis of the Knee: A Randomized Double-blind, Placebo-controlled Trial Completed NCT00532220 Phase 3 Ibandronate IV;Placebo
16 Dynamic Magnetic Resonance (MR) Study in Evaluating the Vertebral Bone Marrow Perfusion and Its Related Research Completed NCT00172224 Phase 3
17 Bypass Surgery and CD133 Marrow Cell Injection for Treatment of Ischemic Heart Failure Completed NCT00462774 Phase 2, Phase 3
18 Autologous Bone Marrow Derived Stem Cells for Acute Myocardial Infarction Completed NCT01167751 Phase 3
19 Endocardial Stem Cells Approach Efficacy Completed NCT00841958 Phase 3
20 C-Cure Clinical Trial Completed NCT00810238 Phase 2, Phase 3
21 Tamoxifen Study Completed NCT00000529 Phase 3 tamoxifen
22 An Efficacy and Safety Study of Ixmyelocel-T in Patients With Critical Limb Ischemia (CLI) Completed NCT01483898 Phase 3
23 Defibrotide for Patients With Hepatic Veno-occlusive Disease: A Treatment IND Study Completed NCT00628498 Phase 3 Defibrotide;Defibrotide
24 Randomized Clinical Trial for the Treatment of Osteonecrosis of the Femoral Head Recruiting NCT01892514 Phase 3
25 The Efficacy and Safety of Rexmyelocel-T to Treat Ischemic Ulcers in Subjects With CLI Rutherford Category 5 and DM Recruiting NCT03174522 Phase 3 Rexmyelocel-T;Placebo
26 Intracoronary Infusion of Mononuclear Cells Autologous Bone Marrow in Patients With Chronic Coronary Occlusion and Ventricular Dysfunction, Previously Revascularized. Recruiting NCT02022514 Phase 2, Phase 3 Conventional medical treatment
27 The Efficacy and Safety of Rexmyelocel-T to Treat Ischemic Rest Pain in Subjects With CLI Rutherford Category 4 and DM Recruiting NCT03111238 Phase 3 Rexmyelocel-T;Placebo
28 Efficacy and Safety of Allogeneic Mesenchymal Precursor Cells (Rexlemestrocel-L) for the Treatment of Heart Failure. Recruiting NCT02032004 Phase 3
29 Safety and Efficacy Study of Autologous Bone Marrow Aspirate Concentrate for No-Option Critical Limb Ischemia Active, not recruiting NCT01818310 Phase 2, Phase 3
30 Allogeneic Mesenchymal Stromal Cells for Angiogenesis and Neovascularization in No-option Ischemic Limbs Not yet recruiting NCT03042572 Phase 2, Phase 3 Allogeneic Mesenchymal Stromal Cell
31 Congestive Heart Failure Cardiopoietic Regenerative Therapy (CHART-2) Trial - THE CHART-2 TRIAL Not yet recruiting NCT02317458 Phase 3
32 Cell Therapy in Chronic Ischemic Heart Disease Terminated NCT00362388 Phase 3
33 Intramyocardial Transplantation of Bone Marrow Stem Cells in Addition to Coronary Artery Bypass Graft (CABG) Surgery Terminated NCT00950274 Phase 3 CD133+ autologous bone marrow stem cell;Placebo
34 Effect of Exercise and Phytoestrogen on Bone, Metabolic Syndrome Criteria and Complaints of the Early Menopause Terminated NCT00663104 Phase 3
35 Cell Therapy in Myocardial Infarction Terminated NCT00350766 Phase 2, Phase 3
36 Effect of Vitamin D Supplement on Inflammation Markers in High-Risk Cardiovascular Patients With Chronic Kidney Disease Terminated NCT01012414 Phase 3 paricalcitol;placebo
37 Cell Therapy in Patients With Chronic Ischemic Heart Disease Undergoing Cardiac Surgery Unknown status NCT01267331 Phase 1, Phase 2
38 Direct Endomyocardial Injection of Autologous Bone Marrow Cells to Treat Ischaemic Heart Failure Unknown status NCT01150175 Phase 2
39 Prospective, Controlled and Randomized Clinical Trial on Cardiac Cell Regeneration With Laser and Autologous Bone Marrow Stem Cells, in Patients With Coronary Disease and Refractory Angina Unknown status NCT01214499 Phase 2
40 Safety and Efficacy Study of Autologous BM-MNC Processed by Two Methods for Treating Patients With Chronic Limb Ischemia Unknown status NCT01446055 Phase 1, Phase 2
41 Intra-coronary Versus Intramyocardial Application of Enriched CD133pos Autologous Bone Marrow Derived Stem Cells Unknown status NCT01337011 Phase 1, Phase 2
42 Intracoronary Autologous Mesenchymal Stem Cells Implantation in Patients With Ischemic Dilated Cardiomyopathy Unknown status NCT01720888 Phase 2
43 Safety and Efficacy of Autologous Bone Marrow Stem Cells for Lower Extremity Ischemia Treating Unknown status NCT01903044 Phase 1, Phase 2
44 TACT-NAGOYA: Therapeutic Angiogenesis Using Cell Transplantation Unknown status NCT00145262 Phase 2
45 Mesenchymal Stem Cells to Treat Ischemic Cardiomyopathy Unknown status NCT01913886 Phase 1, Phase 2
46 CD133+ Cell Therapy for Refractory Coronary Heart Disease Unknown status NCT01049867 Phase 1, Phase 2
47 Stem Cell Therapy to Improve Myocardial Function in Patients Undergoing Coronary Artery Bypass Grafting (CABG) Unknown status NCT00395811 Phase 1, Phase 2
48 Combined CABG and Stem-Cell Transplantation for Heart Failure Unknown status NCT00418418 Phase 2
49 The Long-term and Short-term Efficacy and Safety of Transplantation Autologous Bone Marrow Cells (BMCs) in Patients With the First STEMI (ST Segment Elevation Myocardial Infarction) Unknown status NCT01748383 Phase 2
50 Study of ALD-401 Via Intracarotid Infusion in Ischemic Stroke Subjects Unknown status NCT01273337 Phase 2

Search NIH Clinical Center for Ischemic Bone Disease

Genetic Tests for Ischemic Bone Disease

Anatomical Context for Ischemic Bone Disease

MalaCards organs/tissues related to Ischemic Bone Disease:

39
Bone, Bone Marrow, Heart, Endothelial, Kidney, Spinal Cord, Breast

Publications for Ischemic Bone Disease

Articles related to Ischemic Bone Disease:

id Title Authors Year
1
Bone marrow edema: mild or nascent variant of ischemic bone disease. ( 18083442 )
2008

Variations for Ischemic Bone Disease

Expression for Ischemic Bone Disease

Search GEO for disease gene expression data for Ischemic Bone Disease.

Pathways for Ischemic Bone Disease

GO Terms for Ischemic Bone Disease

Cellular components related to Ischemic Bone Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 ACAN BGLAP BMP2 COL2A1 EGFL8 F2
2 Golgi lumen GO:0005796 9.33 ACAN BGLAP F2
3 extracellular space GO:0005615 9.32 ACAN BGLAP BMP2 COL2A1 F2 PTH

Biological processes related to Ischemic Bone Disease according to GeneCards Suite gene sharing:

(show all 26)
id Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.8 ACAN COL2A1 SERPINE1 TNFRSF11B
2 response to ethanol GO:0045471 9.79 BGLAP PTH TBXAS1
3 osteoblast differentiation GO:0001649 9.76 BGLAP BMP2 RUNX2
4 response to vitamin D GO:0033280 9.63 BGLAP PTH
5 signal peptide processing GO:0006465 9.62 BGLAP F2
6 osteoblast development GO:0002076 9.61 BGLAP RUNX2
7 chondrocyte differentiation GO:0002062 9.61 BMP2 COL2A1 RUNX2
8 chondrocyte development GO:0002063 9.6 ACAN RUNX2
9 positive regulation of ossification GO:0045778 9.59 BMP2 PTH
10 response to inorganic substance GO:0010035 9.58 BGLAP TNFRSF11B
11 cellular response to BMP stimulus GO:0071773 9.58 BMP2 COL2A1 RUNX2
12 regulation of osteoclast differentiation GO:0045670 9.57 BGLAP TNFSF11
13 positive regulation of blood coagulation GO:0030194 9.56 F2 SERPINE1
14 peptidyl-glutamic acid carboxylation GO:0017187 9.55 BGLAP F2
15 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus GO:1901522 9.54 BMP2 RUNX2
16 negative regulation of fibrinolysis GO:0051918 9.52 F2 SERPINE1
17 proteoglycan metabolic process GO:0006029 9.51 BMP2 COL2A1
18 regulation of odontogenesis of dentin-containing tooth GO:0042487 9.48 BMP2 RUNX2
19 TNFSF11-mediated signaling pathway GO:0071847 9.46 TNFRSF11A TNFSF11
20 bone resorption GO:0045453 9.43 ACP5 PTH TNFSF11
21 ossification GO:0001503 9.43 BGLAP BMP2 COL2A1 RUNX2 TNFRSF11A TNFSF11
22 positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 9.37 TNFRSF11A TNFSF11
23 mammary gland alveolus development GO:0060749 9.33 TNFRSF11A TNFSF11 VEGFA
24 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848 9.32 TNFRSF11A TNFSF11
25 skeletal system development GO:0001501 9.17 ACAN BGLAP BMP2 COL2A1 PTH RUNX2
26 positive regulation of transcription from RNA polymerase II promoter GO:0045944 10.09 BMP2 PTH RUNX2 SERPINE1 TNFSF11 VEGFA

Molecular functions related to Ischemic Bone Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 BMP2 TNFRSF11B TNFSF11 VEGFA

Sources for Ischemic Bone Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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