Aliases & Classifications for Ischemic Heart Disease

MalaCards integrated aliases for Ischemic Heart Disease:

Name: Ischemic Heart Disease 37
Coronary Arteriosclerosis 69
Myocardial Ischemia 69
Ihd 44

Classifications:



External Ids:

ICD10 32 I20-I25

Summaries for Ischemic Heart Disease

MalaCards based summary : Ischemic Heart Disease, also known as coronary arteriosclerosis, is related to kawasaki disease and coronary heart disease 1, and has symptoms including other and unspecified angina pectoris and angina pectoris. An important gene associated with Ischemic Heart Disease is NOS3 (Nitric Oxide Synthase 3), and among its related pathways/superpathways are Metabolism of water-soluble vitamins and cofactors and Lipoprotein metabolism. The drugs Angiotensin II and Olmesartan have been mentioned in the context of this disorder. Affiliated tissues include Limb and Bone, and related phenotypes are Decreased free cholesterol and Increased LDL uptake

Related Diseases for Ischemic Heart Disease

Diseases related to Ischemic Heart Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 322)
# Related Disease Score Top Affiliating Genes
1 kawasaki disease 31.0 CCL2 CRP IL6 NPPB TNF
2 coronary heart disease 1 30.7 ACE APOA1 APOB APOE CRP F7
3 apnea, obstructive sleep 30.2 CRP IL6 TNF
4 diabetes mellitus 30.2 ACE CRP IL6 TNF
5 angina pectoris 30.2 ACE CRP IL6
6 chlamydia 30.0 CRP IL6 TNF
7 acute myocardial infarction 29.9 ACE CRP NPPB
8 takayasu arteritis 29.7 CRP IL6 TNF
9 spondylitis 29.7 CRP IL6 TNF
10 aortic valve disease 2 29.7 ACE CRP NPPB
11 systolic heart failure 29.6 ACE CRP IL6 NPPB
12 pneumonia 29.6 CCL2 CRP IL6 TNF
13 periodontitis 29.4 CCL2 CRP IL6 TNF
14 peripheral vascular disease 29.4 ACE APOA1 APOB CRP IL6
15 homocysteinemia 29.4 CRP MTHFR NOS3
16 chronic kidney failure 29.3 ACE CRP IL6 NPPB
17 hypercholesterolemia, familial 29.3 APOA1 APOB APOE CRP LPL
18 peritonitis 29.2 CCL2 CRP IL6 TNF
19 coronary stenosis 29.1 ACE APOA1 APOB APOE CRP IL6
20 lipid metabolism disorder 29.1 ACE APOA1 APOB APOE CRP LPL
21 multiple sclerosis 29.0 APOE CCL2 IL6 TNF
22 sleep apnea 28.9 ACE APOE CRP IL6 NOS3 NPPB
23 arteriosclerosis 28.8 ACE APOA1 APOB APOE CCL2 CRP
24 hypertrophic cardiomyopathy 28.7 ACE FHOD3 IL6 NPPB TNF
25 dilated cardiomyopathy 28.7 ACE CRP FHOD3 IL6 NOS3 NPPB
26 heart disease 28.6 ACE APOB APOE CRP F7 IL6
27 hypertension, essential 28.4 ACE APOA1 APOB CRP LPL NOS3
28 carotid stenosis 28.1 ACE APOE CRP F7 MTHFR TNF
29 body mass index quantitative trait locus 11 28.1 APOA1 APOB APOE CCL2 CRP IL6
30 stroke, ischemic 27.8 ACE APOB APOE CRP F7 MTHFR
31 cerebrovascular disease 27.5 ACE APOA1 APOB APOE CRP F7
32 vascular disease 27.4 ACE APOA1 APOB APOE CCL2 CRP
33 coronary artery anomaly 27.2 ACE APOA1 APOB APOE CRP IL6
34 arteries, anomalies of 26.5 ACE APOA1 APOB APOE CCL2 CRP
35 myocardial infarction 26.4 ACE APOA1 APOB APOE CCL2 CRP
36 sick sinus syndrome 10.9
37 moderate and severe traumatic brain injury 10.6 ACE APOE
38 xanthoma disseminatum 10.5 APOB APOE
39 intracranial vasospasm 10.5 APOE NOS3
40 hypercholesterolemia, autosomal dominant, type b 10.5 APOB APOE
41 hyperlipoproteinemia, type v 10.5 APOE LPL
42 familial lcat deficiency 10.5 APOA1 APOE
43 cold agglutinin disease 10.5 CRP IL6
44 defective apolipoprotein b-100 10.5 APOB APOE
45 subacute cutaneous lupus erythematosus 10.5 ACE TNF
46 skin sarcoidosis 10.5 ACE TNF
47 renal artery disease 10.4 ACE NOS3
48 generalized atherosclerosis 10.4 ACE APOE CRP
49 diabetic foot ulcers 10.4 CRP IL6
50 cryopyrin-associated periodic syndrome 10.4 CRP IL6

Comorbidity relations with Ischemic Heart Disease via Phenotypic Disease Network (PDN): (show top 50) (show all 201)


Acquired Thrombocytopenia Active Peptic Ulcer Disease
Acute Anterolateral Myocardial Infarction Acute Apical Periodontitis
Acute Conjunctivitis Acute Cor Pulmonale
Acute Cystitis Acute Kidney Failure
Acute Myocardial Infarction Acute Myocarditis
Acute Pancreatitis Acute Stress Disorder
Acute Vascular Insufficiency of Intestine Adjustment Disorder
Alcoholic Cardiomyopathy Allergic Urticaria
Anthracosis Anxiety
Aortic Aneurysm Aortic Atherosclerosis
Aortic Valve Disease 1 Aortic Valve Disease 2
Aortic Valve Insufficiency Asbestosis
Atrioventricular Block Atrophic Gastritis
Atypical Depressive Disorder Autonomic Nervous System Disease
Bacteremia 2 Basilar Artery Insufficiency
Benign Essential Hypertension Benign Hypertensive Renal Disease
Benign Renovascular Hypertension Bicipital Tenosynovitis
Bladder Cancer Bleeding Disorder, Platelet-Type, 11
Blepharoconjunctivitis Bronchitis
Bronchopneumonia Buerger Disease
Cardiac Arrest Cardiac Arrhythmia
Cardiogenic Shock Central Nervous System Origin Vertigo
Central Retinal Artery Occlusion Cerebral Atherosclerosis
Cerebral Degeneration Cerebrovascular Disease
Cholecystitis Chronic Intestinal Vascular Insufficiency

Graphical network of the top 20 diseases related to Ischemic Heart Disease:



Diseases related to Ischemic Heart Disease

Symptoms & Phenotypes for Ischemic Heart Disease

UMLS symptoms related to Ischemic Heart Disease:


other and unspecified angina pectoris, angina pectoris

GenomeRNAi Phenotypes related to Ischemic Heart Disease according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased free cholesterol GR00340-A-2 9.26 APOA1 APOB APOE LPL
2 Increased LDL uptake GR00340-A-1 8.8 APOA1 APOE LPL

MGI Mouse Phenotypes related to Ischemic Heart Disease:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.11 TNF CRP NOS3 F7 ACE FHOD3
2 homeostasis/metabolism MP:0005376 10.03 TNF APOE MTHFR CRP NOS3 F7
3 growth/size/body region MP:0005378 10.02 NOS3 TNF LPL APOE MTHFR F7
4 adipose tissue MP:0005375 9.95 TNF LPL APOE NOS3 F7 ACE
5 liver/biliary system MP:0005370 9.76 TNF APOE NOS3 ACE IL6 APOA1
6 mortality/aging MP:0010768 9.65 NOS3 TNF LPL APOE MTHFR F7
7 muscle MP:0005369 9.17 TNF LPL APOE NOS3 FHOD3 IL6

Drugs & Therapeutics for Ischemic Heart Disease

Drugs for Ischemic Heart Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1043)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Angiotensin II Approved, Investigational Phase 4,Phase 3,Phase 2,Early Phase 1 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
2
Olmesartan Approved, Investigational Phase 4,Phase 2 144689-24-7, 144689-63-4 158781 130881
3
Everolimus Approved Phase 4,Phase 3,Phase 2,Phase 1 159351-69-6 6442177
4
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
5
Sirolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 53123-88-9 46835353 6436030 5284616
6
Clopidogrel Approved Phase 4,Phase 2,Phase 3,Phase 1 120202-66-6, 113665-84-2 60606
7
Ticagrelor Approved Phase 4,Phase 3,Phase 2,Phase 1 274693-27-5 9871419
8
Ticlopidine Approved Phase 4,Phase 2,Phase 3,Phase 1 55142-85-3 5472
9
Cilostazol Approved, Investigational Phase 4,Phase 3,Phase 2 73963-72-1 2754
10
Ranolazine Approved, Investigational Phase 4,Phase 3,Phase 2 95635-55-5, 142387-99-3 56959
11
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 9005-49-6 46507594 772
12
Tirofiban Approved Phase 4,Phase 3,Phase 2,Phase 1 144494-65-5 60947
13
Menthol Approved Phase 4,Phase 3,Phase 2,Early Phase 1 2216-51-5 16666
14
Chlorhexidine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 55-56-1 2713 9552079
15
Chromium Approved Phase 4,Phase 2,Phase 3,Phase 1 7440-47-3 27668
16
Simvastatin Approved Phase 4,Phase 3,Phase 2,Phase 1 79902-63-9 54454
17
Trimetazidine Approved, Investigational Phase 4 5011-34-7
18
Insulin Glargine Approved Phase 4,Phase 3 160337-95-1
19
Metformin Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 657-24-9 4091 14219
20
Zinc Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 7440-66-6 32051 23994
21
Acarbose Approved, Investigational Phase 4,Phase 3 56180-94-0 441184
22
Amlodipine Approved Phase 4,Phase 3,Phase 2 88150-42-9 2162
23
Aspirin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 50-78-2 2244
24
Pioglitazone Approved, Investigational Phase 4,Phase 3,Phase 2 111025-46-8 4829
25
Rivaroxaban Approved Phase 4,Phase 3,Phase 2 366789-02-8
26
Warfarin Approved Phase 4,Phase 2,Phase 3 81-81-2 54678486 6691
27
Paclitaxel Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 33069-62-4 36314
28
Pitavastatin Approved Phase 4,Phase 3 147511-69-1, 147526-32-7 5282452 6366718
29
Rosiglitazone Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 122320-73-4 77999
30
Fluvastatin Approved Phase 4,Phase 3,Phase 2 93957-54-1 1548972
31
Ezetimibe Approved Phase 4,Phase 3,Phase 2,Phase 1 163222-33-1 150311
32
Lovastatin Approved, Investigational Phase 4,Phase 2,Phase 3 75330-75-5 53232
33
Bivalirudin Approved, Investigational Phase 4,Phase 3,Phase 2 128270-60-0 16129704
34
Carvedilol Approved, Investigational Phase 4,Phase 3,Phase 1 72956-09-3 2585
35
Thrombin Approved, Investigational Phase 4,Phase 2,Phase 3
36
Vorapaxar Approved Phase 4,Phase 3,Phase 2,Phase 1 618385-01-6
37
Metoprolol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 51384-51-1, 37350-58-6 4171
38
Adenosine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 58-61-7 60961
39
Dipyridamole Approved Phase 4,Phase 3,Phase 2,Phase 1 58-32-2 3108
40
Regadenoson Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 313348-27-5 219024
41
Nicorandil Approved, Investigational Phase 4,Phase 3 65141-46-0 47528
42
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2 1994-09-7, 94-09-7 2337
43
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 76631-46-4, 113775-47-6 5311068 56032 68602
44
Etomidate Approved Phase 4 33125-97-2 667484 36339
45
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
46
Ropivacaine Approved Phase 4 84057-95-4 175805 71273
47
Sevoflurane Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 28523-86-6 5206
48
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
49
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 3 73590-58-6 4594
50
Pantoprazole Approved Phase 4,Phase 3,Phase 1 102625-70-7 4679

Interventional clinical trials:

(show top 50) (show all 7245)

# Name Status NCT ID Phase Drugs
1 Efficacy Study of Olmesartan Medoxomil on Coronary Atherosclerosis and Epicardial Adipose Tissue(EAT) Unknown status NCT02360956 Phase 4 Olmesartan medoxomil tablets;Antihypertensive medication (per doctor suggestion)
2 The Beneficial Role of Percutaneous Coronary Intervention Over Optimal Medical Therapy in Elderly Patients With Coronary Artery Disease Unknown status NCT01508663 Phase 4 ARB, CCB, ACE-inhibitor, statin, Nitrate, Antiplate etc.
3 Endothelial Dysfunction in Subjects With History of Premature Coronary Artery Disease Unknown status NCT00917527 Phase 4 Atorvastatin
4 Safety and Efficacy of Low-dose Ticagrelor in Chinese Patients With Stable Coronary Artery Disease Unknown status NCT02514642 Phase 4 low-dose ticagrelor;Clopidogrel
5 Rosuvastatin Effect on Reducing Coronary Atherosclerosis Plaques Volume Unknown status NCT01382277 Phase 4 Rosuvastatin
6 A Trial to Evaluate Efficacy of Heart-protecting Musk Pill Unknown status NCT01897805 Phase 4 Heart-protecting Musk Pill;Placebo
7 Effect of Cilostazol on Endothelial Progenitor Cells and Endothelial Function in Coronary Artery Disease Unknown status NCT02174939 Phase 4 Cilostazol;Dummy Placebo
8 Danshen Dropping Pill for Coronary Heart Disease Heart and Artery Structure and Function Unknown status NCT01825759 Phase 4 danshen dripping pill
9 The Prediction of Extent and Risk Profile of Coronary Atherosclerosis and Their Changes During Lipid-lowering Therapy Based on Non-invasive Techniques Unknown status NCT01773512 Phase 4 Rosuvastatin
10 The Association Between Very Small Embryonic-like Stem Cells and the Prognosis of Coronary Artery Disease Patients Unknown status NCT01633359 Phase 4 Intensive statin;Routine statin
11 Ranolazine for Improving Symptoms of Palpitations Unknown status NCT01495520 Phase 4 Ranolazine;Placebo
12 Efficacy and Safety of Different Dose of Tirofiban in Interventional Treatment of Complex Coronary Artery Disease Unknown status NCT02294994 Phase 4 tirofiban
13 Clinical Evaluation of Magnetic Resonance Imaging in Coronary Heart Disease-2 Unknown status NCT01664858 Phase 4
14 Firebird 2 Versus Excel Sirolimus-eluting Stent in Treating Real-world Patients With Coronary Artery Disease Unknown status NCT01373632 Phase 4
15 Pharmacodynamic Comparison of Rosuvastatin Versus Atorvastatin on Platelet Reactivity in Patients With Coronary Artery Disease on Dual Antiplatelet Therapy With New P2Y12 Inhibitors (Trial gRANADa) Unknown status NCT02030054 Phase 4 Atorvastatin;Rosuvastatin
16 Study to Investigate the Effect of Heart Rate Reduction With Ivabradine on Vascular Elastic Properties and Endothelial Function in Patients With Stable Coronary Heart Disease Unknown status NCT01768585 Phase 4 Ivabradine;Placebo
17 BioMime Vs. Xience Randomised Control Clinical Study Unknown status NCT02112981 Phase 4
18 Low-dose Statins and Nutraceuticals in High-intensity Statin-intolerant Patients Unknown status NCT02001883 Phase 4 Association low-dose statin and nutraceuticals
19 The ImPact of Trimetazidine on MicrOcirculation After Stenting for Stable Coronary Artery Disease Unknown status NCT02107144 Phase 4 trimetazidine
20 Can Insulin Glargine Improve Myocardial Function in Patients With T2D and Coronary Artery Disease (CAD) Unknown status NCT01035528 Phase 4 insulin glargine;metformin
21 Impact of Acarbose on Abnormal Glucose Regulation in Patients With Coronary Artery Disease (AAA Trial) Unknown status NCT00858676 Phase 4 acarbose
22 Xience/Promus for Long Coronary Lesion Registry Unknown status NCT01147237 Phase 4
23 Cerebral Artery Stenosis, Coronary Artery Disease and Arrhythmia Unknown status NCT00247533 Phase 4
24 A Prospective Multicenter Trial Evaluating Helios Biodegradable Polymer SES Safety and Effectiveness in CAD Treatment Unknown status NCT01880879 Phase 4
25 Pharmacodynamic Effects of Atorvastatin vs. Rosuvastatin on Platelet Reactivity Unknown status NCT01567774 Phase 4 Atorvastatin;Rosuvastatin
26 Pharmacodynamic Effects of Ranolazine Versus Amlodipine on Platelet Reactivity Unknown status NCT01490255 Phase 4 Ranolazine;Amlodipine
27 Treatment of Coronary Atherosclerosis by Insulin Sensitizers in Insulin-Resistant Patients Unknown status NCT00155350 Phase 4 pioglitazone
28 Rivaroxaban in Patients With Atrial Fibrillation and Coronary Artery Disease Undergoing Percutaneous Coronary Intervention Unknown status NCT02334254 Phase 4 rivaroxaban and ticagrel therapy;triple antithrombotic regimen with warfarin, asipirin and clopidogrel
29 Atrial Fibrillation and Ischemic Events With Rivaroxaban in Patients With Stable Coronary Artery Disease Study Unknown status NCT02642419 Phase 4 Rivaroxaban and single antiplatelet drug (aspirin, clopidogrel or prasugrel);Rivaroxaban
30 Safety and Effectiveness of the Coronary Momo Stent Unknown status NCT01535625 Phase 4
31 Clinical Study of Combination Therapy for Angina of Coronary Heart Disease With Aspirin and Salvianolate Injection Unknown status NCT02694848 Phase 4 Salvianolate injection;Aspirin
32 Harmonizing Optimal Strategy for Treatment of Coronary Artery Stenosis - SAfety & EffectiveneSS of Drug-ElUting Stents & Anti-platelet REgimen Unknown status NCT01267734 Phase 4 Triple anti-platelet therapy (TAT);Double-dose clopidogrel anti-platelet therapy (DDAT)
33 Study Effects of Ginkgo Biloba Extract on Endothelial Cell Function and Genetic Effects on the Response to Ginkgo Biloba Extract in Diabetic Patients With Stable Coronary Artery Disease Unknown status NCT01038050 Phase 4 Ginkgo Biloba Extract (GBE)
34 Assessment of Surface Coverage of Two Types of DES in Diabetes Mellitus and Non- Diabetes Mellitus Unknown status NCT01023919 Phase 4
35 Overcoming High On-Treatment Platelet Reactivity (HPR) During Prasugrel Therapy With Ticagrelor Unknown status NCT01869309 Phase 4 Prasugrel;Ticagrelor
36 PharmacOdynamic compaRison of piTavastatin Versus atOrvastatin on Platelet Reactivity Unknown status NCT01648829 Phase 4 Atorvastatin;Pitavastatin
37 Multivessel Stenting Versus Staged Revascularization With Zotarolimus-eluting Stent for STEMI Unknown status NCT01781715 Phase 4
38 Rosiglitazone Therapy In The Prevention Of Coronary Artery Disease In Patients With Impaired Glucose Tolerance Unknown status NCT00733174 Phase 4 Rosiglitazone;Placebo
39 Fluvastatin AmelIorates aTHerosclerosis Study Unknown status NCT01681199 Phase 4 Fluvastatin extended release tablet
40 Cholesterol-lowering Effects of nutraceuticaLs Versus Ezetimibe in Statin-intolerant Patients Unknown status NCT01807078 Phase 4 Ezetimibe
41 Ranolazine, Ethnicity and the Metabolic Syndrome Unknown status NCT01304095 Phase 4 Ranolazine
42 Diagnostic Benefits of HyperQTM vs. Conventional ECG Stress Test. Comparison of HyperQ vs. Stress ECG in Women Before Angiography Unknown status NCT00850486 Phase 4
43 Trial to Assess the Everolimus-Eluting Coronary Stent System (PROMUS Element) for Coronary Revascularization Unknown status NCT01342822 Phase 4
44 Comparison of Biolimus-eluting Biodegradable Polymer, Everolimus-eluting and Sirolimus-eluting Coronary Stents Unknown status NCT01268371 Phase 4
45 Plasma and Platelet microRNAs in Clopidogrel Low Response Patients Unknown status NCT02447809 Phase 4 Clopidogrel;acetylsalicylic acid (ASA)
46 A Registry To Evaluate Safety And Effectiveness Of Everolimus Drug Eluting Stent For Coronary Revascularization Unknown status NCT01157455 Phase 4 Aspirin;Clopidogrel;Heparin or Bivalirudin
47 Periodontal Therapy in Coronary Artery Patients Unknown status NCT01609725 Phase 4
48 Italian Diffuse/Multivessel Disease ABSORB Prospective Registry: IT-Disappears Unknown status NCT02004730 Phase 4
49 The Effects of Omega 3 and Vitamin E Supplementation on the Serum Antioxidant Enzymes and Gene Expressions of PGC-1a, h TERT, FOXOs and SIRTs in CAD Patients Unknown status NCT02011906 Phase 4
50 Diagnostic Performance of Noninvasive Fractional Flow Reserve From Computed Tomography Unknown status NCT01747317 Phase 4

Search NIH Clinical Center for Ischemic Heart Disease

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Ischemic Heart Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Ischemic Heart Disease:
ACT34-CMI, bone marrow-derived cells for ischemic heart diseases
Adipocell
Adipose-derived mesenchymal stromal stem cells for ischemic heart disease
ADRCs, adipose-derived regenerative cells for cardiovascular disease
AMDC, autologous muscle-derived cells for ischemic heart failure
Autologous bone marrow-derived mesenchymal stem cells for treatment of heart muscle damage
Bone marrow-derived CD133+ stem cells for treatment of ischemic heart disease
Bone marrow-derived mesenchymal stem cells for treatment of heart diseases
Bone marrow-derived mesenchymal stem cells for treatment of ischemic cardiomyopathy
Bone marrow-derived mesenchymal stem cells for treatment of ischemic cardiomyopathy during artery bypass grafting
Bone marrow-derived mesenchymal stem cells for treatment of ischemic heart disease
Bone marrow-derived mononuclear cells for ischemic cardiomyopathy
Bone marrow-derived mononucleated cells for heart disease
Bone marrow-derived stem cells for treatment of chronic ischemic heart failure
Bone marrow-derived stem cells for treatment of ischemic cardiomyopathy
Bone marrow-derived stem cells for treatment of severe chronic ischemic heart disease
Cardiac stem cells for treatment of ischemic cardiomyopathy
Cardiocell
Combination therapy of mononuclear cells with laser for coronary disease
Embryonic stem cell-derived cardiomyocytes for ischemic myocardium
Enriched bone marrow-derived progenitor cells for heart diseases
itMSC, bone marrow-derived mesenchymal stem cells for cardiovascular diseases
Mesendo, stem cell combination for treatment of cardiovascular diseases
Peripheral mononuclear cells CD34+ stem cells for treatment of myocardial ischemia
Peripheral or bone marrow-derived stem cells for chronic heart failure
StempeucelICM
Embryonic/Adult Cultured Cells Related to Ischemic Heart Disease:
Bone marrow-derived CD34+ stem cells (ACT34) PMIDs: 11283669 12551872 22163120 20448213 9020076 17562958 21737787
VEGF-A165-stimulated ADSCs
Adipose-derived stem and regenerative cells PMIDs: 21082397 22281257
Autologous muscle-derived cells
Bone marrow-derived mesenchymal stem cells (family) PMIDs: 21052537 19591227
Bone marrow-derived CD133+ cells
Bone marrow-derived mesenchymal stem cells PMIDs: 22940024 21392602
Bone marrow-derived hematopoietic stem cells (family)
Bone marrow-derived stem cells
Bone marrow-derived mononuclear cells (family) PMIDs: 21392602 22940024
Porcine bone marrow-derived mesenchymal stem cells PMIDs: 21392602 22940024
Human cardiac stem cells PMIDs: 22088800 22965994
Cardiomyocyte-like cells PMIDs: 18941512
Bone marrow-derived progenitor cells PMIDs: 23362308 22936827 18794392 16990384 16990385 22651868
Bone marrow-derived mononuclear cells PMIDs: 21323410 20631864
Bone marrow-derived mesenchymal stem cells PMIDs: 21323410 20631864
Peripheral blood-derived hematopoietic stem cells (family)
Bone marrow-derived mononuclear cells PMIDs: 20668107 21596713 19761394 22834565
Bone marrow-derived mesenchymal stem cells (Stempeucel PMIDs: 18720444

Genetic Tests for Ischemic Heart Disease

Anatomical Context for Ischemic Heart Disease

MalaCards organs/tissues related to Ischemic Heart Disease:

38
Heart, Endothelial, Bone, Testes, Kidney, Bone Marrow, Breast
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Ischemic Heart Disease:
# Tissue Anatomical CompartmentCell Relevance
1 Limb Pelvic Girdle Bone Marrow Stromal Cells Potential therapeutic candidate
2 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate

Publications for Ischemic Heart Disease

Articles related to Ischemic Heart Disease:

(show top 50) (show all 1162)
# Title Authors Year
1
The effect of exercise therapy on depressive and anxious symptoms in patients with ischemic heart disease: A systematic review. ( 29332638 )
2018
2
Corrigendum to "Endothelial dysfunction mediated by interleukin-18 in patients with ischemic heart disease undergoing coronary artery bypass grafting surgery" [Med. Hypotheses 104 (2017) 20-24]. ( 29406994 )
2018
3
Increased left ventricular mass index is present in patients with type 2 diabetes without ischemic heart disease. ( 29343820 )
2018
4
Integrated Modules Analysis to Explore the Molecular Mechanisms of Phlegm-Stasis Cementation Syndrome with Ischemic Heart Disease. ( 29403392 )
2018
5
Favorable effects of statins in the treatment of heart failure with preserved ejection fraction in patients without ischemic heart disease. ( 29307549 )
2018
6
Sex Differences in Ischemic Heart Disease: Advances, Obstacles, and Next Steps. ( 29449443 )
2018
7
Prevalence of Takayasu arteritis in young women with acute ischemic heart disease. ( 29249430 )
2018
8
Spontaneously occurring intramural coronary arteriosclerosis in regularly slaughtered veal calves and beef cattle: aA screening study about prevalence and histopathological features. ( 29371083 )
2018
9
Hybrid Imaging in Ischemic Heart Disease. ( 29329818 )
2018
10
Relationships between road-distance to primary care facilities and ischemic heart disease and stroke mortality in Hokkaido, Japan: A Bayesian hierarchical approach to ecological count data. ( 29340259 )
2018
11
Disconnect Between Genes Associated With Ischemic Heart Disease and Targets of Ischemic Heart Disease Treatments. ( 29396305 )
2018
12
Effect of Baseline Antiarrhythmic Drug on Outcomes With Ablation in Ischemic Ventricular Tachycardia: A VANISH Substudy (Ventricular Tachycardia Ablation Versus Escalated Antiarrhythmic Drug Therapy in Ischemic Heart Disease). ( 29305400 )
2018
13
Increased risk of ischemic heart disease, hypertension, and type 2 diabetes in women with previous gestational diabetes mellitus, a target group in general practice for preventive interventions: A population-based cohort study. ( 29337985 )
2018
14
A portable prototype magnetometer to differentiate ischemic and non-ischemic heart disease in patients with chest pain. ( 29351337 )
2018
15
Association between unplanned readmission to a different hospital and all-cause mortality among older patients with ischemic heart disease: A nationwide claim study. ( 29371060 )
2018
16
Physicians Addicted to Prescribing Aspirin-a Disorder Of Cardiologists (PAPA-DOC) Syndrome: The Headache of Nonevidence-Based Medicine for Ischemic Heart Disease? ( 29413373 )
2018
17
Lifestyle factors and subsequent ischemic heart disease risk after hematopoietic cell transplantation. ( 29315507 )
2018
18
Epistasis analysis of metabolic genes polymorphisms associated with ischemic heart disease in Yucatan. ( 29395491 )
2018
19
Selective Pressure-Regulated Retroinfusion for Gene Therapy Application in Ischemic Heart Disease. ( 27910055 )
2017
20
Mental stress-induced left ventricular dysfunction and adverse outcome in ischemic heart disease patients. ( 28067532 )
2017
21
The association between insulin resistance, metabolic syndrome, and ischemic heart disease among Rumoi residents. ( 29264065 )
2017
22
The Effects of Age, Period, and Cohort on Mortality from Ischemic Heart Disease in China. ( 28067846 )
2017
23
Increased Hazard of Myocardial Infarction With Insulin-Provision Therapy in Actively Smoking Patients With Diabetes Mellitus and Stable Ischemic Heart Disease: The BARI 2D (Bypass Angioplasty Revascularization Investigation 2 Diabetes) Trial. ( 28903941 )
2017
24
The Association Between Giant Cell Arteritis and Ischemic Heart Disease: A Population Based Cross-Sectional Study. ( 28786254 )
2017
25
Modified mRNA as a therapeutic tool to induce cardiac regeneration in ischemic heart disease. ( 27911047 )
2017
26
Role of TLR4 and miR-155 in peripheral blood mononuclear cell-mediated inflammatory reaction in coronary slow flow and coronary arteriosclerosis patients. ( 28407320 )
2017
27
Guidelines in review: ACC/AATS/AHA/ASE/ASNC/SCAI/SCCT/STS 2017 appropriate use criteria for coronary revascularization in patients with stable ischemic heart disease. ( 28836156 )
2017
28
Thyroid function and ischemic heart disease: a Mendelian randomization study. ( 28819171 )
2017
29
Myofilament remodeling and function is more impaired in peripartum cardiomyopathy compared to dilated cardiomyopathy and ischemic heart disease. ( 28935576 )
2017
30
Self-Rated Health Status and Risk of Ischemic Heart Disease in the China Kadoorie Biobank Study: A Population-Based Cohort Study. ( 28939702 )
2017
31
Comparison of Coronary CT Angiography, SPECT, PET, and Hybrid Imaging for Diagnosis of Ischemic Heart Disease Determined by Fractional Flow Reserve. ( 28813561 )
2017
32
Tumor necrosis factor-alpha gene polymorphisms and susceptibility to ischemic heart disease: A systematic review and meta-analysis. ( 28383437 )
2017
33
Left-sided breast cancer and risks of secondary lung cancer and ischemic heart disease : Effects of modern radiotherapy techniques. ( 28916844 )
2017
34
Seasonal Periodicity of Ischemic Heart Disease and Heart Failure. ( 28865777 )
2017
35
A Case of Subclavian Artery Aneurysm with History of Ischemic Heart Disease Operated Under Cervical Epidural Anesthesia. ( 28298800 )
2017
36
MicroRNA-31 promotes adverse cardiac remodeling and dysfunction in ischemic heart disease. ( 28865712 )
2017
37
Polyphenols and Oxidative Stress in Atherosclerosis-Related Ischemic Heart Disease and Stroke. ( 29317985 )
2017
38
Small airway dysfunction in smokers with stable ischemic heart disease. ( 28846677 )
2017
39
Estimation of Antioxidant Levels in Saliva and Serum of Chronic Periodontitis Patients with and without Ischemic Heart Disease. ( 28781595 )
2017
40
Cardioprotective Effects of Pomegranate (Punica granatum) Juice in Patients with Ischemic Heart Disease. ( 28913846 )
2017
41
Impact of diabetes on heart failure incidence in adults with ischemic heart disease. ( 28947278 )
2017
42
Activation of Yap1/Taz signaling in ischemic heart disease and dilated cardiomyopathy. ( 29154888 )
2017
43
Cryopreserved Off-the-Shelf Allogeneic Adipose-Derived Stromal Cells for Therapy in Patients with Ischemic Heart Disease and Heart Failure-A Safety Study. ( 28880460 )
2017
44
Sudden Cardiac Death in Women With Suspected Ischemic Heart Disease, Preserved Ejection Fraction, and No Obstructive Coronary Artery Disease: A Report From the Women's Ischemia Syndrome Evaluation Study. ( 28862961 )
2017
45
Spinal cord infarction mimicking ischemic heart disease. ( 28717781 )
2017
46
Differential proteome profile in ischemic heart disease: Prognostic value in chronic angina versus myocardial infarction. A proof of concept. ( 28501389 )
2017
47
The long-term risk of smoking in diabetic patients with stable ischemic heart disease treated with intensive medical therapy and lifestyle modification. ( 28517955 )
2017
48
Influence of the amount of myocardium subtended to a coronary stenosis on the index of microcirculatory resistance. Implications for the invasive assessment of microcirculatory function in ischemic heart disease. ( 28485281 )
2017
49
Epidemiology of ischemic heart disease in HIV. ( 28799997 )
2017
50
Plasma sphingosine-1-phosphate concentrations are associated with systolic heart failure in patients with ischemic heart disease. ( 28709768 )
2017

Variations for Ischemic Heart Disease

ClinVar genetic disease variations for Ischemic Heart Disease:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 NOS3 NM_000603.4(NOS3): c.894T> G (p.Asp298Glu) single nucleotide variant risk factor rs1799983 GRCh37 Chromosome 7, 150696111: 150696111

Expression for Ischemic Heart Disease

LifeMap Discovery
Genes differentially expressed in tissues of Ischemic Heart Disease patients vs. healthy controls: 35
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 EIF1AY eukaryotic translation initiation factor 1A, Y-linked Heart + 3.61 0.020
2 LEP leptin Heart + 3.55 0.003
3 MFSD4 major facilitator superfamily domain containing 4 Endothelium + 3.54 0.000
4 FOSB FBJ murine osteosarcoma viral oncogene homolog B Heart + 3.13 0.012
5 DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked Heart + 3.12 0.017
6 RBP4 retinol binding protein 4, plasma Heart + 3.11 0.011
Search GEO for disease gene expression data for Ischemic Heart Disease.

Pathways for Ischemic Heart Disease

Pathways related to Ischemic Heart Disease according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.48 APOA1 APOB APOE LPL MTHFR
2
Show member pathways
12.45 APOA1 APOB APOE LPL
3
Show member pathways
12.43 CCL2 IL6 NOS3 TNF
4
Show member pathways
12.36 ACE CCL2 IL6 TNF
5
Show member pathways
12.17 APOA1 APOB APOE LPL
6 11.92 IL6 LPL TNF
7 11.88 CCL2 IL6 TNF
8 11.84 CCL2 IL6 TNF
9
Show member pathways
11.8 IL6 NOS3 TNF
10 11.79 CCL2 IL6 TNF
11
Show member pathways
11.77 APOA1 APOB APOE
12 11.69 CCL2 IL6 TNF
13
Show member pathways
11.63 APOA1 APOB APOE LPL
14
Show member pathways
11.61 APOA1 APOB APOE CCL2 CRP F7
15 11.52 CCL2 IL6 TNF
16 11.45 CCL2 IL6 NOS3 TNF
17 11.39 CCL2 IL6 TNF
18 11.38 CCL2 IL6 TNF
19 11.35 APOB IL6 TNF
20 11.29 APOE IL6 TNF
21 11.15 APOA1 IL6 TNF
22 11.11 CCL2 IL6 NOS3
23 11.05 ACE APOE CCL2
24 10.99 IL6 MTHFR TNF
25 10.82 CCL2 TNF
26 10.41 CRP IL6 TNF

GO Terms for Ischemic Heart Disease

Cellular components related to Ischemic Heart Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.83 APOA1 APOB APOE F7 IL6
2 endocytic vesicle lumen GO:0071682 9.58 APOA1 APOB APOE
3 low-density lipoprotein particle GO:0034362 9.54 APOA1 APOB APOE
4 intermediate-density lipoprotein particle GO:0034363 9.5 APOA1 APOB APOE
5 discoidal high-density lipoprotein particle GO:0034365 9.46 APOA1 APOE
6 very-low-density lipoprotein particle GO:0034361 9.46 APOA1 APOB APOE LPL
7 extracellular space GO:0005615 9.36 ACE APOA1 APOB APOE CCL2 CRP
8 chylomicron GO:0042627 9.26 APOA1 APOB APOE LPL
9 extracellular region GO:0005576 10 ACE APOA1 APOB APOE CCL2 CRP

Biological processes related to Ischemic Heart Disease according to GeneCards Suite gene sharing:

(show all 47)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.99 APOB CRP IL6 TNF
2 post-translational protein modification GO:0043687 9.98 APOA1 APOB APOE IL6
3 lipid transport GO:0006869 9.88 APOA1 APOB APOE
4 cellular response to lipopolysaccharide GO:0071222 9.86 CCL2 IL6 TNF
5 cellular protein metabolic process GO:0044267 9.86 APOA1 APOB APOE IL6
6 steroid metabolic process GO:0008202 9.85 APOA1 APOB APOE
7 defense response to Gram-positive bacterium GO:0050830 9.82 CRP IL6 TNF
8 cholesterol metabolic process GO:0008203 9.81 APOA1 APOB APOE
9 regulation of blood pressure GO:0008217 9.77 ACE NOS3 NPPB
10 cholesterol homeostasis GO:0042632 9.71 APOA1 APOB APOE LPL
11 positive regulation of chemokine production GO:0032722 9.7 IL6 TNF
12 humoral immune response GO:0006959 9.7 CCL2 IL6 TNF
13 reverse cholesterol transport GO:0043691 9.69 APOA1 APOE
14 regulation of blood vessel size GO:0050880 9.69 NOS3 NPPB
15 nitric oxide mediated signal transduction GO:0007263 9.68 APOE NOS3
16 high-density lipoprotein particle remodeling GO:0034375 9.68 APOA1 APOE
17 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.67 APOB LPL
18 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.67 APOE TNF
19 lipopolysaccharide-mediated signaling pathway GO:0031663 9.67 CCL2 NOS3 TNF
20 retinoid metabolic process GO:0001523 9.67 APOA1 APOB APOE LPL
21 regulation of blood vessel diameter GO:0097746 9.66 ACE NPPB
22 high-density lipoprotein particle assembly GO:0034380 9.66 APOA1 APOE
23 low-density lipoprotein particle remodeling GO:0034374 9.65 APOB APOE
24 positive regulation of leukocyte chemotaxis GO:0002690 9.65 F7 IL6
25 triglyceride homeostasis GO:0070328 9.65 APOA1 APOE LPL
26 phospholipid efflux GO:0033700 9.64 APOA1 APOE
27 neutrophil mediated immunity GO:0002446 9.63 ACE IL6
28 negative regulation of platelet activation GO:0010544 9.63 APOE NOS3
29 lipoprotein metabolic process GO:0042157 9.63 APOA1 APOB APOE
30 positive regulation of cholesterol esterification GO:0010873 9.62 APOA1 APOE
31 high-density lipoprotein particle clearance GO:0034384 9.62 APOA1 APOE
32 chylomicron remnant clearance GO:0034382 9.61 APOB APOE
33 neuron projection regeneration GO:0031102 9.61 APOA1 APOE
34 cholesterol efflux GO:0033344 9.61 APOA1 APOB APOE
35 regulation of Cdc42 protein signal transduction GO:0032489 9.59 APOA1 APOE
36 positive regulation of cholesterol storage GO:0010886 9.58 APOB LPL
37 very-low-density lipoprotein particle remodeling GO:0034372 9.58 APOE LPL
38 negative regulation of hydrolase activity GO:0051346 9.57 APOA1 NOS3
39 negative regulation of cytokine secretion involved in immune response GO:0002740 9.55 APOA1 TNF
40 very-low-density lipoprotein particle clearance GO:0034447 9.54 APOB APOE
41 lipoprotein catabolic process GO:0042159 9.51 APOB APOE
42 chylomicron assembly GO:0034378 9.5 APOA1 APOB APOE
43 negative regulation of lipid storage GO:0010888 9.43 CRP IL6 TNF
44 lipoprotein biosynthetic process GO:0042158 9.33 APOA1 APOB APOE
45 triglyceride catabolic process GO:0019433 9.26 APOA1 APOB APOE LPL
46 chylomicron remodeling GO:0034371 8.92 APOA1 APOB APOE LPL
47 inflammatory response GO:0006954 10 CCL2 CRP IL6 TNF

Molecular functions related to Ischemic Heart Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phospholipid binding GO:0005543 9.54 APOA1 APOB APOE
2 lipid transporter activity GO:0005319 9.33 APOA1 APOB APOE
3 lipoprotein particle binding GO:0071813 9.32 APOA1 APOE
4 phosphatidylcholine-sterol O-acyltransferase activator activity GO:0060228 9.26 APOA1 APOE
5 low-density lipoprotein particle receptor binding GO:0050750 9.13 APOB APOE CRP
6 cholesterol transporter activity GO:0017127 8.8 APOA1 APOB APOE

Sources for Ischemic Heart Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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