MCID: ISC006
MIFTS: 51

Ischemic Heart Disease malady

Cardiovascular diseases category

Aliases & Classifications for Ischemic Heart Disease

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Ischemic Heart Disease, Aliases & Descriptions:

Name: Ischemic Heart Disease 30 11
Coronary Arteriosclerosis 60
 
Myocardial Ischemia 60
Ihd 37


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


External Ids:

ICD1025 I20-I25

Summaries for Ischemic Heart Disease

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MalaCards based summary: Ischemic Heart Disease, also known as coronary arteriosclerosis, is related to arteriosclerosis and hyperlipidemia type 3. An important gene associated with Ischemic Heart Disease is ZNF202 (zinc finger protein 202), and among its related pathways are Cholesterol and Sphingolipids transport Recycling to plasma membrane in lung normal and CF and Selected targets of HNF1. The compounds polyethylene glycol 6000 and maxepa have been mentioned in the context of this disorder. Affiliated tissues include heart, bone and bone marrow, and related mouse phenotypes are immune system and cardiovascular system.

Related Diseases for Ischemic Heart Disease

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Diseases related to Ischemic Heart Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 124)
idRelated DiseaseScoreTop Affiliating Genes
1arteriosclerosis30.8APOA1, APOB
2hyperlipidemia type 330.7APOB, APOA1
3kawasaki disease30.6CRP, NPPB
4spondylitis30.6CHI3L1
5coronary stenosis30.5APOA1, APOB
6cerebrovascular disease30.5ACE, APOB, APOA1
7peripheral vascular disease30.2APOB, ACE, APOA1
8atrial fibrillation30.1ACE, NPPB
9amyloidosis30.1NPPB, APOA1, CRP
10obesity30.1CRP, KCNJ5, APOA4, APOA1, F7, APOB
11atherosclerosis29.8APOA4, APOA1, APOB, F7, CRP, CHI3L1
12myocardial infarction29.6APOA1, F7, NPPB, CRP, ACE, APOB
13vascular disease29.5F7, CRP, APOA4, APOA1, ACE, APOB
14coronary artery disease29.4ACE, CRP, NPPB, F7, APOA1, APOB
15acute myocardial infarction29.0APOB, APOA1, ACE, F7, NPPB, KCNJ5
16endotheliitis10.6
17ischemia10.5
18chylomicron retention disease10.5APOB
19pelvic inflammatory disease10.5CRP
20cerebral atherosclerosis10.5APOA1
21breast cancer10.4
22rheumatoid arthritis10.4
23arthritis10.4
24eye disease10.4CRP
25vaccinia10.4
26dilated cardiomyopathy10.3
27influenza10.3
28sleep apnea10.3
29hyperalphalipoproteinemia10.3APOA1, APOB
30hypoalphalipoproteinemia10.3APOB, APOA1
31arcus senilis10.3APOB, APOA1
32hyperlipidemia, familial combined10.3APOB, APOA1
33norum disease10.3APOB, APOA1
34hypertriglyceridemia10.3APOB, APOA1
35congestive heart failure10.3
36obstructive sleep apnea10.3
37pneumonia10.3
38hypobetalipoproteinemia10.3APOA1, APOB
39secondary amyloidosis10.3APOA1, CRP
40abetalipoproteinemia10.3APOB, APOA1
41familial hyperlipidemia10.3APOB, APOA1
42tangier disease10.2APOA1, APOB
43oligohydramnios10.2ACE
44angina pectoris10.2
45hepatitis10.2
46hyperuricemia10.2
47arteriosclerosis obliterans10.2
48artery disease10.2
49obstructive lung disease10.2
50prostatitis10.2

Graphical network of the top 20 diseases related to Ischemic Heart Disease:



Diseases related to ischemic heart disease

Symptoms for Ischemic Heart Disease

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Drugs & Therapeutics for Ischemic Heart Disease

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Drug clinical trials:

Search ClinicalTrials for Ischemic Heart Disease

Search NIH Clinical Center for Ischemic Heart Disease

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Ischemic Heart Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Ischemic Heart Disease:
ACT34-CMI, bone marrow-derived cells for ischemic heart diseases
Adipocell
Adipose-derived mesenchymal stromal stem cells for ischemic heart disease
ADRCs, adipose-derived regenerative cells for treatment of cardiovascular disease
AMDC, autologous muscle-derived cells for ischemic heart failure
Autologous bone marrow-derived mesenchymal stem cells for treatment of heart muscle damage
Bone marrow-derived CD133+ stem cells for treatment of ischemic heart disease
Bone marrow-derived mesenchymal stem cells for treatment of heart diseases
Bone marrow-derived mesenchymal stem cells for treatment of ischemic heart disease
Bone marrow-derived mononuclear cells for ischemic cardiomyopathy
Bone marrow-derived mononucleated cells for heart disease
Bone marrow-derived stem cells for treatment of chronic ischemic heart failure
Bone marrow-derived stem cells for treatment of ischemic cardiomyopathy
Bone marrow-derived stem cells for treatment of severe chronic ischemic heart disease
Cardiac stem cells for treatment of ischemic cardiomyopathy
Cardiocell
CD34+ stem cells for treatment of congestive heart failure
Combination therapy of mononuclear cells with laser for coronary disease
Embryonic stem cell-derived cardiomyocytes for ischemic myocardium
Enriched bone marrow-derived progenitor cells for heart diseases
Mesendo, stem cell combination for treatment of cardiovascular diseases
Peripheral mononuclear cells CD34+ stem cells for treatment of myocardial ischemia
Peripheral or bone marrow-derived stem cells for chronic heart failure
StempeucelICM
Embryonic/Adult Cultured Cells Related to Ischemic Heart Disease:
Bone marrow-derived CD34+ stem cells (ACT34), PMIDs: 11283669, 12551872, 22163120, 20448213, 9020076, 17562958, 21737787
VEGF-A165-stimulated ADSCs
Adipose-derived stem and regenerative cell, PMIDs: 21082397, 22281257
Autologous muscle-derived cells
Bone marrow-derived mesenchymal stem cells (family)
Bone marrow-derived CD133+ cells
Bone marrow-derived mesenchymal stem cells , PMID: 22940024
Bone marrow-derived mesenchymal stem cells (family), PMIDs: 21052537, 19591227
Bone marrow-derived hematopoietic stem cells (family)
Bone marrow-derived stem cells
Bone marrow-derived mesenchymal stem cells , PMIDs: 21392602, 22940024
Bone marrow-derived mononuclear cells (family), PMIDs: 21392602, 22940024
Porcine bone marrow-derived mesenchymal stem cells, PMIDs: 21392602, 22940024
Human cardiac stem cells, PMIDs: 22088800, 22965994
Bone marrow-derived mesenchymal stem cells (family)
Bone marrow-derived hematopoietic stem cells (family), PMID: 22163120
Bone marrow-derived mononuclear cells (family)
Cardiomyocyte-like cells, PMID: 18941512
Bone marrow-derived progenitor cells, PMIDs: 23362308, 22936827, 18794392, 16990384, 16990385, 22651868
Bone marrow-derived mononuclear cells, PMIDs: 21323410, 20631864
Bone marrow-derived mesenchymal stem cells, PMIDs: 21323410, 20631864
Peripheral blood-derived hematopoietic stem cells (family)
Bone marrow-derived mononuclear cells, PMIDs: 20668107, 21596713, 19761394, 22834565
Bone marrow-derived mesenchymal stem cells (Stempeucel, PMID: 18720444

Genetic Tests for Ischemic Heart Disease

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Anatomical Context for Ischemic Heart Disease

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MalaCards organs/tissues related to Ischemic Heart Disease:

31
Heart, Bone, Bone marrow, Endothelial, Testes, Breast, Brain, Lung, Prostate, Eye, Spinal cord, Kidney, Placenta, Neutrophil

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Ischemic Heart Disease:
id TissueAnatomical CompartmentCell Relevance
1 LimbPelvic GirdleBone Marrow Stromal Cells Potential therapeutic candidate
2 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate

Animal Models for Ischemic Heart Disease or affiliated genes

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MGI Mouse Phenotypes related to Ischemic Heart Disease:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.6APOA1, CHI3L1, ACE, CRP, TRIB1, APOA4
2MP:00053857.2F7, KCNJ5, APOA4, APOA1, APOB, ACE
3MP:00053767.1APOA4, APOA1, APOB, ACE, CRP, GCLM

Publications for Ischemic Heart Disease

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Articles related to Ischemic Heart Disease:

(show top 50)    (show all 828)
idTitleAuthorsYear
1
Global and regional functional assessment of ischemic heart disease with cardiac MR imaging. (25727001)
2015
2
Incident ischemic heart disease and recent occupational exposure to particulate matter in an aluminum cohort. (23982120)
2014
3
Update on Ischemic Heart Disease and Critical Care Cardiology. (24412103)
2014
4
Ischemic heart disease risk factors in lead exposed workers: research study. (23607481)
2013
5
Assessment of high on-treatment platelet reactivity in patients with ischemic heart disease: concordance between the Multiplate and VerifyNow assays. (23253198)
2013
6
Pseudoxanthoma elasticum and ischemic heart disease. (23611493)
2013
7
Ischemic heart disease after breast cancer radiotherapy. (23802526)
2013
8
Ischemic heart disease in women. (23820324)
2013
9
ABSORB II randomized controlled trial: a clinical evaluation to compare the safety, efficacy, and performance of the Absorb everolimus-eluting bioresorbable vascular scaffold system against the XIENCE everolimus-eluting coronary stent system in the treatment of subjects with ischemic heart disease caused by de novo native coronary artery lesions: rationale and study design. (23137495)
2012
10
Complex biphasic relationship between epicardial fat and ischemic heart disease. (22850244)
2012
11
Mobile radiofrequency does not interfere with antiarrhythmic drugs in patients with ischemic heart disease. (23112972)
2012
12
Relationship of self-reported exercise tolerance with inflammatory markers in women with stable ischemic heart disease. (23183510)
2012
13
Aspirin resistance and ischemic heart disease on Iranian experience. (23210092)
2012
14
Impact of metabolic syndrome on ischemic heart disease - a prospective cohort study in an Iranian adult population: Isfahan Cohort Study. (21195593)
2012
15
Ischemic heart disease in patients undergoing dialysis. (23299034)
2012
16
Ancient Theory about Public Health through Physical Activity against Hyperlipidemia and Ischemic Heart Disease. (23304669)
2012
17
Mental stress and ischemic heart disease: evolving awareness of a complex association. (21627481)
2011
18
Glutamine is cardioprotective in patients with ischemic heart disease following cardiopulmonary bypass. (22167767)
2011
19
Continuous intravenous infusion of prostaglandin E1 improves myocardial perfusion reserve in patients with ischemic heart disease assessed by positron emission tomography: a pilot study. (21461596)
2011
20
Clinical role of the Duke Activity Status Index in the selection of the optimal type of stress myocardial perfusion imaging study in patients with known or suspected ischemic heart disease. (21971704)
2011
21
Dementia and depression with ischemic heart disease: a population-based longitudinal study comparing interventional approaches to medical management. (21387018)
2011
22
Erectile dysfunction, depression, and ischemic heart disease: does the existence of one component of this triad necessitate inquiring the other two? (21457466)
2011
23
Intraoperative diagnosis of bilateral coronary ostia stenosis: a rare case of ischemic heart disease in a 3-month-old patient. (22051282)
2011
24
The Magnitude of Mortality from Ischemic Heart Disease Attributed to Occupational Factors in Korea - Attributable Fraction Estimation Using Meta-analysis. (22953190)
2011
25
Women have less severe and extensive coronary atherosclerosis in fatal cases of ischemic heart disease: an autopsy study. (21473966)
2011
26
Agreement of left ventricular mass in steady state free precession and delayed enhancement MR images: implications for quantification of fibrosis in congenital and ischemic heart disease. (20096134)
2010
27
Validation of physician billing and hospitalization data to identify patients with ischemic heart disease using data from the Electronic Medical Record Administrative data Linked Database (EMRALD). (20847968)
2010
28
Is the demand-control model still a usefull tool to assess work-related psychosocial risk for ischemic heart disease? Results from 14 year follow up in the Copenhagen City Heart study. (20971698)
2010
29
Ischemic heart disease in women: many questions, few facts. (20160161)
2010
30
Genetic vulnerability and phenotypic expression of depression and risk for ischemic heart disease in the Vietnam era twin study of aging. (20190130)
2010
31
CD14 C-260T gene polymorphism and ischemic heart disease susceptibility: a HuGE review and meta-analysis. (19346955)
2009
32
Systematic review: comparative effectiveness of angiotensin-converting enzyme inhibitors or angiotensin II-receptor blockers for ischemic heart disease. (20008762)
2009
33
The influence of simvastatin on hsCRP and some paramneters of hemostasis in patients with ischemic heart disease]. (18663903)
2008
34
Comparative assessment of antiinflammatory action of atorvastatin in ischemic heart disease and rheumatoid arthritis]. (18991814)
2008
35
Immunoglobulin E in patients with ischemic heart disease. (18651396)
2008
36
Functional promoter variant in zinc finger protein 202 predicts severe atherosclerosis and ischemic heart disease. (18652945)
2008
37
An application of the patient rule-induction method for evaluating the contribution of the Apolipoprotein E and Lipoprotein Lipase genes to predicting ischemic heart disease. (17436307)
2007
38
Neoangiogenesis and coronary atherosclerosis: diagnostic value of a novel biochemical marker placenta growth factor in patients with ischemic heart disease]. (17159877)
2006
39
Oxidized LDL and lipids as risk factors for ischemic heart disease in type 2 diabetes]. (16171015)
2005
40
Correlation of high-sensitivity CRP concentration with the extent of coronary atherosclerosis in men with symptoms of ischemic heart disease]. (16161944)
2005
41
Antioxidant action and therapeutic efficacy of laser irradiation of blood in patients with ischemic heart disease]. (12852010)
2003
42
Is it expendient to prescribe ACE inhibitors in stable ischemic heart disease?]. (12968600)
2003
43
Clinical use of C-reactive protein for the prognostic stratification of patients with ischemic heart disease. (11305527)
2001
44
The expanding role of HMG-CoA reductase inhibitors (statins) in the prevention and treatment of ischemic heart disease. (11743453)
2001
45
Polymorphic markers of endothelial NO-synthase and angiotensin II vascular receptor genes and predisposition to ischemic heart disease]. (11190479)
2000
46
Association of mutations in the apolipoprotein B gene with hypercholesterolemia and the risk of ischemic heart disease. (9867529)
1998
47
Different secretion profiles of atrial and brain natriuretic peptides after acute volume loading in patients with ischemic heart disease. (9217917)
1997
48
Apolipoprotein A-I and B levels and the risk of ischemic heart disease during a five-year follow-up of men in the QuAcbec cardiovascular study. (8759066)
1996
49
Sex hormones and DHEA-SO4 in relation to ischemic heart disease mortality in diabetic subjects. The Wisconsin Epidemiologic Study of Diabetic Retinopathy. (8886548)
1996
50
The relationship of the restriction fragment length polymorphism of the apo-B gene to the blood lipid spectrum in patients with ischemic heart disease]. (7900201)
1994

Variations for Ischemic Heart Disease

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Expression for genes affiliated with Ischemic Heart Disease

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Search GEO for disease gene expression data for Ischemic Heart Disease.

Pathways for genes affiliated with Ischemic Heart Disease

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Compounds for genes affiliated with Ischemic Heart Disease

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Compounds related to Ischemic Heart Disease according to GeneCards Suite gene sharing:

(show top 50)    (show all 115)
idCompoundScoreTop Affiliating Genes
1polyethylene glycol 60004310.1APOA1, APOB
2maxepa4310.1APOA1, APOB
3lynestrenol439.9APOB, APOA1
4colestipol439.9APOA1, APOB
5levonorgestrel43 59 28 1212.9APOB, APOA1, F7
6tibolone439.8CRP, APOB, APOA1
7ezetimibe43 1210.8CRP, APOB, APOA1
8retinyl palmitate43 2410.8APOA1, APOB, APOA4
9intralipid439.8APOA1, APOB, APOA4
10rosuvastatin43 49 28 1212.7APOA1, APOB, CRP
11cerivastatin49 43 28 1212.7APOA1, CRP, APOB
12cholesterol ester439.7APOA1, APOB, APOA4
13bezafibrate43 28 1211.6APOA1, APOB, CRP
14mspi439.6APOB, APOA4, APOA1
15hydrochlorothiazide43 28 49 24 1213.5CRP, ACE, APOA1
16fenofibrate43 49 1211.4APOA1, APOB, CRP
17fosinopril43 1210.4ACE, NPPB, CRP
18celiprolol439.4ACE, NPPB
19ramipril43 1210.4ACE, CRP, NPPB
20valsartan43 59 28 1212.4CRP, ACE, NPPB
21telmisartan43 28 1211.4NPPB, ACE, CRP
22perindopril43 49 1211.4ACE, NPPB, CRP
23alacepril439.3ACE, NPPB
24pioglitazone28 43 49 1212.3NPPB, APOB, APOA1, CRP
25uric acid43 2410.3APOB, CRP, APOA1, NPPB
26kininogen439.3APOA1, APOB, ACE, F7
27sildenafil28 43 49 24 1213.3ACE, KCNJ5, NPPB
28homocysteine43 2410.3NPPB, APOB, APOA1, CRP
29enalapril43 49 1211.3NPPB, APOA1, ACE
30vitamin a43 24 1211.2APOA4, APOA1, CRP, APOB
31fluvastatin43 49 28 1212.2CRP, ACE, APOB, APOA1
32metformin43 49 1211.2CRP, ACE, APOB, APOA1
33candoxatril43 1210.2ACE, NPPB
34furosemide43 59 28 49 24 1214.2APOB, ACE, NPPB
35fibrinogen439.2APOA4, APOA1, APOB, CRP, F7
36nitroglycerin43 1210.1KCNJ5, ACE, NPPB, CRP
37captopril43 59 49 28 1213.1APOB, APOA1, ACE, NPPB
38atenolol43 49 28 24 1213.1APOA1, ACE, CRP, NPPB
39lactate439.0KCNJ5, APOA1, APOB, CRP, NPPB
40prostacyclin438.9APOA1, NPPB, CRP, ACE
41pravastatin43 49 28 24 1212.7ACE, NPPB, CRP, APOA1, APOB
42atorvastatin43 49 28 24 1212.7NPPB, ACE, APOB, APOA1, CRP
43aspirin43 49 28 2411.7APOB, ACE, CRP, NPPB, APOA1
44acetylcholine43 49 28 24 1212.7NPPB, ACE, APOA1, CRP, KCNJ5
45cholesterol43 28 24 1211.3ZNF202, APOA4, F7, APOA1, APOB, ACE
46testosterone43 59 24 1211.3KCNJ5, NPPB, CRP, APOB, APOA1
47creatinine438.1APOA1, APOA4, APOB, ACE, CRP, NPPB
48nitric oxide43 24 129.8NPPB, KCNJ5, CHI3L1, F7, ACE, GCLM
49glucose437.8KCNJ5, APOA4, APOB, F7, NPPB, CRP
50lipid437.5APOB, KCNJ5, APOA4, APOA1, ZNF202, CRP

GO Terms for genes affiliated with Ischemic Heart Disease

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Cellular components related to Ischemic Heart Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chylomicronGO:00426279.7APOA4, APOB
2high-density lipoprotein particleGO:00343649.7APOA1, APOA4
3endocytic vesicle lumenGO:00716829.7APOB, APOA1
4very-low-density lipoprotein particleGO:00343619.5APOB, APOA1, APOA4
5endoplasmic reticulum lumenGO:00057889.2F7, APOB, APOA1, APOA4
6early endosomeGO:00057699.1APOB, APOA1, APOA4
7extracellular regionGO:00055767.7APOA4, APOA1, APOB, ACE, CRP, NPPB
8extracellular spaceGO:00056157.0F7, APOA4, APOA1, APOB, CHI3L1, ACE

Biological processes related to Ischemic Heart Disease according to GeneCards Suite gene sharing:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1lipoprotein biosynthetic processGO:004215810.0APOB, APOA1
2regulation of intestinal cholesterol absorptionGO:00303009.9APOA1, APOA4
3positive regulation of cholesterol esterificationGO:00108739.9APOA4, APOA1
4organ regenerationGO:00311009.8F7, APOA1
5phospholipid effluxGO:00337009.8APOA4, APOA1
6high-density lipoprotein particle remodelingGO:00343759.7APOA4, APOA1
7cholesterol transportGO:00303019.7APOA1, APOB
8cholesterol effluxGO:00333449.7APOB, APOA1, APOA4
9lipoprotein metabolic processGO:00421579.7APOA4, APOA1, APOB
10retinoid metabolic processGO:00015239.7APOB, APOA1, APOA4
11cholesterol homeostasisGO:00426329.6APOA4, APOA1, APOB
12cholesterol metabolic processGO:00082039.6APOB, APOA1, APOA4
13regulation of blood vessel sizeGO:00508809.6GCLM, NPPB
14phototransduction, visible lightGO:00076039.5APOB, APOA1, APOA4
15regulation of vasodilationGO:00423129.5ACE, NPPB
16reverse cholesterol transportGO:00436919.4APOA1, APOA4

Molecular functions related to Ischemic Heart Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cholesterol bindingGO:00154859.8CRP, APOA1
2phosphatidylcholine-sterol O-acyltransferase activator activityGO:00602289.4APOA1, APOA4
3cholesterol transporter activityGO:00171279.3APOB, APOA1, APOA4

Products for genes affiliated with Ischemic Heart Disease

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Sources for Ischemic Heart Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet