Ischemic Heart Disease malady

Wikipedia: Ischaemic or ischemic heart disease (IHD), or myocardial ischaemia, is a disease characterized by...⁴⁴ more...

MalaCards: Ischemic Heart Disease, also known as myocardial ischemia, is related to coronary arteriosclerosis and hypertension. An important gene associated with Ischemic Heart Disease is HDLCQ1 (high density lipoprotein cholesterol level QTL 1), and among its related pathways are ACE Inhibitor Pathway, Pharmacodynamics and Statin Pathway, Pharmacodynamics. The compounds atenolol and dmso have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, brain and heart, and related mouse phenotypes are respiratory system and endocrine/exocrine gland.

Disease Ontology: An extrinsic cardiomyopathy that is characterized by reduced blood supply to the cardiac muscles.⁶

Aliases & Descriptions:

ischemic heart disease 6 myocardial ischemia 6 8 32 43 chronic myocardial ischaemia 6

chronic myocardial ischemia 43 coronary arteriosclerosis 43 ihd 26

Diseases related to ischemic heart disease by text searches and GeneDecks gene sharing:

(show top 50)    (show all 954)

id	Related Disease	Score	Top Affiliating Genes
1	coronary arteriosclerosis	34.8	SELE, VCL, IL6, APOA1, APOB, APOE
2	hypertension	34.7	REN, GNB3, NOS2, NOS3, ACE, AGT
3	atherosclerosis	33.5	SELE, CETP, MMP3, FABP12, ELN
4	hypertensive heart disease	31.3	MMP1, MMP9, PPARA, ACE, AGT, AGTR1
5	arthritis	31.0	SELL, SERPINA1, MMP3, IL1B, IL6, IL8
6	familial hypercholesterolemia	30.9	COG2, PCSK9, LPA, LPL, LIPC, MTTP
7	lipoprotein lipase deficiency	30.8	LPA, LPL, CETP, INS, APOA1, APOB
8	congestive heart failure	30.2	PIK3C2A, COG2, REN, UCN, XDH, HMGCR
9	alcoholism	30.0	GSR, IL1RN, AKR1A1, GHRL, HMGCR, CYCS
10	arteriosclerosis obliterans	29.8	SELP, VCAM1, FGF2, ICAM1, PF4, EDN1
11	diabetes, type 2	29.8	SELE, MMP3, INS, ALB, PPARG, NOS3
12	aortic disease	29.3	REN, MMP1, MMP9, IL6, ELN
13	hepatitis	29.0	SELP, SERPINA1, XDH, GSR, IL2RB, F2
14	arteriosclerosis	28.4	COG2, SELE, SELP, SERPINE1, LPA, LPL
15	hypertrophic cardiomyopathy	28.3	PIK3C2A, REN, VWF, SELP, VCL, ATP2A2
16	werner syndrome	27.8	SERPINE1, INS, INSR, IL6, APOE, MAPK14
17	type 2 diabetes mellitus	27.7	COG2, VWF, GCKR, SELE, SELL, SELP
18	hyperuricemia	27.5	PIK3C2A, REN, SELP, SERPINE1, LPL, LIPC
19	hemophilia	27.2	VWF, SELP, SERPINC1, CKM, MTHFR, IL1B
20	alpha 1-antitrypsin deficiency	27.2	SERPINC1, SERPINA1, SERPINE1, VEGFA, MPO, CD14
21	hyperlipidemia	26.6	PIK3C2A, COG2, VWF, PCSK9, SELP, SERPINC1
22	coronary artery anomaly	25.7	PIK3C2A, COG2, VWF, VTN, SELE, SELP
23	hypercholesterolemia	24.1	PIK3C2A, COG2, VWF, PCSK9, SELE, SELP
24	kawasaki disease	23.6	VWF, SELE, SELL, SELP, SERPINA1, VEGFA
25	diabetic retinopathy	21.7	VWF, VTN, SELE, SELL, SELP, SERPINE1
26	homocysteine	21.5	PIK3C2A, COG2, REN, VWF, SELE, SELP
27	cholesterol	21.1	ZNF202, PIK3CA, PIK3C2A, COG2, REN, KIF6
28	essential hypertension	21.0	COG2, REN, VWF, SELE, SELL, SELP
29	sinusitis	20.1	PIK3CA, VWF, SELL, SELP, SERPINC1, SERPINE1
30	rheumatoid arthritis	19.8	VWF, VTN, SELE, SELL, SELP, SERPINC1
31	diabetes mellitus	19.6	PIK3CA, PIK3C2A, COG2, REN, VWF, VTN
32	pneumonia	19.6	PIK3C2A, COG2, VTN, SELE, SELL, SERPINC1
33	osteoarthritis	19.4	VTN, SERPINA1, SERPINE1, VEGFA, LPA, VCAM1
34	insulin resistance	19.4	PIK3CA, COG2, REN, VWF, GCKR, SELE
35	acute myocardial infarction	19.1	PIK3C2A, COG2, REN, KIF6, VWF, VTN
36	nephropathy	18.7	COG2, REN, VWF, VTN, GCLM, SELE
37	coronary heart disease	18.7	ZNF202, PIK3C2A, COG2, KIF6, VWF, PCSK9
38	blindness	18.6	PIK3C2A, COG2, REN, VWF, SELE, SELP
39	myocardial infarction	18.4	PIK3C2A, COG2, REN, KIF6, VWF, VTN
40	hypoxia	16.8	PIK3CA, PIK3C2A, REN, VWF, VTN, SELE
41	peritonitis	16.8	PIK3C2A, COG2, REN, VWF, VTN, SELE
42	neuronitis	16.5	PIK3CA, PIK3C2A, REN, VWF, PCSK9, GCLM
43	ischemia	16.0	PIK3CA, PIK3C2A, COG2, REN, VWF, VTN
44	cerebritis	15.7	PIK3C2A, COG2, REN, VWF, VTN, SELE
45	obesity	15.3	PIK3CA, PIK3C2A, COG2, REN, VWF, PCSK9
46	hyperalphalipoproteinemia	14.2	LPL, LIPC, CETP, APOA1, APOB, APOC3
47	abetalipoproteinemia	14.2	COG2, PCSK9, LPA, MTTP, APOA1, APOB
48	cetp deficiency	14.1	LPL, LIPC, CETP, APOA1, APOB, APOE
49	hereditary diffuse leukoencephalopathy with spheroids	14.1	LPA, CETP, APOA1, APOB, ABCA1
50	intermediate coronary syndrome	14.1	PIK3C2A, MB, TNNI3, PLAT, PF4, ACE

Approved drugs:

Drug clinical trials:

Cell-based therapeutics:

Human cardiac stem cells, PMIDs: 22088800

MalaCards organs/tissues related to ischemic heart disease:

²²

MGI Mouse Phenotypes related to ischemic heart disease:

²⁵ (show all 24)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.4	PGF, STAT6, ELN, ABCA1, NF2, SELL
2	endocrine/exocrine gland phenotype	MP:0005379	10.3	GGT1, EDNRA, NF2, IL2RB, XDH, SELL
3	hematopoietic system phenotype	MP:0005397	10.3	HGF, CSF3, STAT6, CYCS, AKR1A1, F13A1
4	integument phenotype	MP:0010771	10.1	FGA, ITGB3, ATP2A2, XDH, SELP, IL2RB
5	renal/urinary system phenotype	MP:0005367	9.9	NPPA, DNASE1, AGTR1, INSR, INS, ATP2A2
6	liver/biliary system phenotype	MP:0005370	9.9	APOB, APOA1, IL6, FGA, INS, MTTP
7	embryogenesis phenotype	MP:0005380	9.8	EDNRB, NF2, CYCS, F2, MB, VCL
8	other phenotype	MP:0005395	9.5	NOS2, NOS3, ABCA1, CSF1, CPT1A, PTGS1
9	immune system phenotype	MP:0005387	8.7	DNASE1, AGTR1, AGER, ABCA1, EDNRB, EDNRA
10	digestive/alimentary phenotype	MP:0005381	8.4	GHRL, PTGS1, SST, PLAT, NOS2, NOS3
11	normal phenotype	MP:0002873	8.1	F2, ALB, GHRL, HMGCR, TMSB4X, SST
12	skeleton phenotype	MP:0005390	7.7	CSF1, SOD3, HIF1A, HBEGF, EDNRB, NF2
13	nervous system phenotype	MP:0003631	7.5	ADD1, CP, CSF1, CXCL12, HSPA1A, F2
14	adipose tissue phenotype	MP:0005375	7.2	HADHB, TNF, GHRL, IGF1, CCL2, ENPP1
15	behavior/neurological phenotype	MP:0005386	7.0	PLAT, PPARG, SST, CYCS, PTGS1, TNNI3
16	vision/eye phenotype	MP:0005391	6.8	NF2, NOS3, NOS2, PLAT, PPARG, PTGS2
17	growth/size phenotype	MP:0005378	6.7	VCAM1, LPL, SERPINE1, SELP, SELE, REN
18	reproductive system phenotype	MP:0005389	6.2	MMP9, ATP2A2, LEP, LIPC, VEGFA, REN
19	tumorigenesis	MP:0002006	6.0	CAT, LEP, SERPINE1, SELL, PIK3CA, ATP2A2
20	mortality/aging	MP:0010768	5.7	APOA4, MTTP, MTR, MTHFR, LEP, VCL
21	muscle phenotype	MP:0005369	4.6	IL6, CKM, CLU, VCL, LPL, VEGFA
22	cellular phenotype	MP:0005384	3.4	IGF1, IL27, IL1RN, FGF2, INSR, INS
23	homeostasis/metabolism phenotype	MP:0005376	2.6	ADRB2, KNG1, PGF, CPT1A, CP, NPPA
24	cardiovascular system phenotype	MP:0005385	2.2	VWF, REN, PIK3CA, SELE, HGF, F3

Articles related to ischemic heart disease:

(show top 50)    (show all 270)

id	Title	Authors	Year	Affiliating Genes
1	Diagnosis of ischemic heart disease using CK-MB, trop onin-I and ischemia modified albumin. (21456469)	Dawie J.... Azazh A.	2011	TNNI3, ALB, CKM
2	PCSK9 R46L, low-density lipoprotein cholesterol level s, and risk of ischemic heart disease: 3 independent studies and meta-analyses. (20579540)	Benn M.... Tybjaerg-Hansen A.	2010	PCSK9
3	Allele-specific regulation of MTTP expression influen ces the risk of ischemic heart disease. (19546343)	Aminoff A.... Ehrenborg E.	2010	MTTP
4	Relationship between common lipoprotein lipase gene s equence variants, hyperinsulinemia, and risk of ischemic heart disease: A popul ation-based study. (20347446)	Jeppesen J.... Fenger M.	2010	LPL
5	Genetically elevated apolipoprotein A-I, high-density lipoprotein cholesterol levels, and risk of ischemic heart disease. (20826588)	Haase C.L.... TybjA	2010	APOA1, HDLCQ1
6	Lipoprotein(a) and ischemic heart disease--a causal a ssociation? A review. (20106478)	Kamstrup P.R.	2010	LPA
7	Genetic variation in the ABCA1 gene, HDL cholesterol, and risk of ischemic heart disease in the general population. (19596329)	Frikke-Schmidt R.	2010	ABCA1
8	Motor protein Kinesin-6 and ischemic heart disease]. (20659029)	Koroleva O.S.... ZateA-shchikov D.A.	2010	KIF6
9	N-terminal fragment of the brain natriuretic peptide and proinflammatory cytokines in patients with ischemic heart disease (19537583)	Shalaev S.V.... Volkova S.I.u.	2009	IL6, NPPB
10	Association of loss-of-function mutations in the ABCA1 gene with high-density lipoprotein cholesterol levels and risk of ischemic heart disease. (18523221)	Frikke-Schmidt R.... Tybjaerg-Hansen A.	2008	ABCA1
11	ABCA1 gene mutations, HDL cholesterol levels, and risk of ischemic heart disease. (18984885)	Brunham L.R.... Hayden M.R.	2008	ABCA1
12	Treatment of erectile dysfunction in patients with ischemic heart disease and angina of effort (17918321)	Neimark A.I.... Vorob'eva E.N.	2007	IMPA1
13	The level of C-reactive protein and major artery elasticity in patients with ischemic heart disease (17385467)	Iliukhin O.V.... Lopatin I.u.M.	2007	CRP
14	C-588T polymorphism of the human glutamate-cysteine ligase modifier subunit gene is not associated with the risk and extent of ischemic heart disease in a German cohort. (17924854)	Muehlhause A.... Gardemann A.	2007	GCLM
15	Cell-enhancement strategies for the treatment of ischemic heart disease. (17230207)	Seeger F.H.... Dimmeler S.	2007	MAPK1, NOS3
16	Relationship between renal function at the time of percutaneous coronary intervention and prognosis in ischemic heart disease patients. (17384999)	Inaguma D.... Matsuo S.	2007	CRP
17	Zinc Finger Protein 202: a new candidate gene for ischemic heart disease: The Copenhagen City Heart Study. (16289551)	Stene M.C.... Tybjaerg-Hansen A.	2006	ZNF202
18	How dietary deficiency, genes and a toxin can cooperate to produce arteriosclerosis and ischemic heart disease. (17543200)	Klevay L.M.	2006	MTR, ELN, PON1
19	Celecoxib, ibuprofen, and the antiplatelet effect of aspirin in patients with osteoarthritis and ischemic heart disease. (16952493)	Renda G.... Patrignani P.	2006	PTGS1, PTGS2
20	Cyclosporine A as an effective treatment for a patient with acquired hemophilia A complicated with diabetes mellitus and ischemic heart disease (16440770)	Wano Y.... Hirose Y.	2005	F8
21	The antiplatelet effect of clopidogrel is not attenuated by statin treatment in stable patients with ischemic heart disease. (16113837)	Vinholt P.... Mickley H.	2005	CYP3A4
22	Genetic factors of risk of ischemic heart disease development in patients with familial hypercholesterolemia (16091654)	Meshkov A.N.... Malyshev P.P.	2005	F7, ITGB3, MTHFR
23	Genetic Predictors of Unfavorable Course in High Risk Patients With Ischemic Heart Disease. Data of Follow-up for Two Years. (15699916)	Zateishchikov D.A.... Sidorenko B.A.	2004	LPL, PPARG, PPARA
24	Quantification of D-dimer and soluble fibrin in blood plasma of people with ischemic heart disease and hypertension (16350758)	LugovskoA- E.V.... Komisarenko S.V.	2004	F13A1
25	Antioxidant action and therapeutic efficacy of laser irradiation of blood in patients with ischemic heart disease (12852010)	Volotovskaia A.V.... Filipovich V.N.	2003	SOD1
26	Is it expendient to prescribe ACE inhibitors in stable ischemic heart disease? (12968600)	Makolkin V.I.	2003	ACE
27	Spotlight on abciximab in patients with ischemic heart disease undergoing percutaneous coronary revascularization. (14728074)	Ibbotson T.... Goa K.L.	2003	PLAT, VTN
28	Cracovian program for secondary prevention of ischemic heart disease. Secondary prevention of ischemic heart disease during hospitalization in 1996-97 and 1998-99 (14575013)	Pajak A.... Tracz W.	2003	ACE
29	Genotypes of ACE gene in Kazakh and Uygur patients with ischemic heart disease (11855311)	Baitasova N.B.... Rysmendiev A.Z.h.	2002	ACE
30	Persistent elevation of C-reactive protein and ischemic heart disease in patients with continuous ambulatory peritoneal dialysis. (11840375)	Kim S.B.... Yang W.S.	2002	CRP
31	Standardization of plasma brain natriuretic peptide concentrations in older Japanese-relationship to latent renal dysfunction and ischemic heart disease. (12383147)	Nomura H.... Iguchi A.	2002	NPPB
32	Elevated HDL cholesterol is a risk factor for ischemic heart disease in white women when caused by a common mutation in the cholesteryl ester transfer protein gene. (10779455)	Agerholm-Larsen B.... Tybjaerg-Hansen A.	2000	CETP
33	Common cholesteryl ester transfer protein mutations, decreased HDL cholesterol, and possible decreased risk of ischemic heart disease: The Copenhagen City Heart Study. (11056092)	Agerholm-Larsen B.... Nordestgaard B.G.	2000	CETP
34	Tissue factor and homocysteine levels in ischemic heart disease are associated with angiographically documented clinical recurrences after coronary angioplasty. (10896233)	Marcucci R.... Gensini G.F.	2000	F3
35	Soluble E-selectin is not a marker of unstable coronary plaque in serum of patients with ischemic heart disease. (10590190)	Galvani M.... Nicolini F.A.	2000	SELE
36	The effects of dipyridamole stress test on plasma levels of soluble adhesion molecules intracellular adhesion molecule-1, vascular cell adhesion molecule-1, E-selectin and L-selectin in patients with ischemic heart disease and patients with syndrome X. (10376202)	Siminiak T.... Wysocki H.	1999	SELL
37	Mutations in the lipoprotein lipase gene associated with ischemic heart disease in men. The Copenhagen city heart study. (10364086)	Wittrup H.H.... Nordestgaard B.G.	1999	LPL
38	Evaluation of platelet function and tissue plasminogen activator activity in ischemic heart disease depending on concurrence with hyperlipoproteinemia and aspirin therapy (9640079)	Jastrzebska M.... CheA8stowski K.	1997	SERPINE1, PF4
39	Elevated platelet factor 4 and beta-thromboglobulin plasma levels in depressed patients with ischemic heart disease. (9270907)	Laghrissi-Thode F.... Finkel M.S.	1997	PF4
40	New indices of ischemic heart disease and aging: studies on the serum levels of soluble intercellular adhesion molecule-1 (ICAM-1) and soluble vascular cell adhesion molecule-1 (VCAM-1) in patients with hypercholesterolemia and ischemic heart disease. (9180243)	Morisaki N.... Saito Y.	1997	VCAM1
41	Endothelin-1: a scientist's curiosity, or a real player in ischemic heart disease? (8969576)	Cesari M.... Rossi G.P.	1996	EDN1
42	A prospective evaluation of an angiotensin-converting-enzyme gene polymorphism and the risk of ischemic heart disease. (7854377)	Lindpaintner K.... Hennekens C.H.	1995	ACE
43	Allelic variants of apolipoproteins B and CII genes in patients with ischemic heart disease and in healthy persons from the Moscow population (7590197)	Pogoda T.V.... Limborskaia S.A.	1995	APOB
44	ATP sensitive potassium channels and ischemic heart disease. (8111784)	Gross G.J.	1994	KCNJ5
45	ATP sensitive potassium channels and ischemic heart disease. (8111782)	Chi L.... Lucchesi B.R.	1994	KCNJ5
46	Allopurinol therapy of ischemic heart disease with infarct extension. (1576562)	Parmley L.F.... Downey J.M.	1992	XDH
47	Asymptomatic ischemic heart disease and diabetic nephropathy: relationship between prevalence of asymptomatic ischemic heart disease and urinary albumin excretion rate. (1770034)	Tani N.... Shibata A.	1991	ALB
48	The content of fibronectin, fibrinogen, its degradation products and myoglobin in patients with ischemic heart disease (2095000)	Malaia L.T.... Shuliak L.N.	1990	MB
49	Ischemic heart disease risk in postmenopausal women. Effects of estrogen use on glucose and insulin levels. (2164381)	Barrett-Connor E.... Laakso M.	1990	INS
50	The effect of lovastatin therapy on the dynamics of the clinical state of patients with ischemic heart disease and hyperlipoprotein emia (2274859)	Zhukova I.M.... Lediashova G.A.	1990	LPXN

Genes related to ischemic heart disease according to GeneCards:

(show top 50)    (show all 155)

id	Symbol	Description	Score	GeneCards Section Context
1	HDLCQ1	high density lipoprotein cholesterol level QTL 1	11.0	Publications
2	HRES1	HTLV-1 related endogenous sequence	11.0	Publications
3	ZNF202	zinc finger protein 202	11.0	Publications
4	IL27	interleukin 27	11.0	Publications
5	TRIB1	tribbles homolog 1 (Drosophila)	11.0	Publications
6	TMSB4X	thymosin beta 4, X-linked	11.0	Publications
7	MGP	matrix Gla protein	11.0	Publications
8	UCN	urocortin	11.0	Publications
9	IGES	immunoglobulin E concentration, serum	11.0	Publications
10	KCNJ5	potassium inwardly-rectifying channel, subfamily J, member 5	11.0	Publications
11	LPXN	leupaxin	11.0	Publications
12	CHI3L1	chitinase 3-like 1 (cartilage glycoprotein-39)	11.0	Publications
13	GCKR	glucokinase (hexokinase 4) regulator	11.0	Publications
14	FABP12	fatty acid binding protein 12	11.0	Publications
15	F7	coagulation factor VII (serum prothrombin conversion accelerator)	11.0	Publications
16	SOD3	superoxide dismutase 3, extracellular	11.0	Publications
17	GCLM	glutamate-cysteine ligase, modifier subunit	11.0	Publications
18	CKM	creatine kinase, muscle	11.0	Publications
19	HADHB	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit	11.0	Publications
20	TNNI3	troponin I type 3 (cardiac)	11.0	Publications
21	IMPA1	inositol(myo)-1(or 4)-monophosphatase 1	11.0	Publications
22	APOB	apolipoprotein B (including Ag(x) antigen)	11.0	Publications
23	PF4	platelet factor 4	11.0	Publications
24	IRAK1	interleukin-1 receptor-associated kinase 1	11.0	Publications
25	APOA1	apolipoprotein A-I	11.0	Publications
26	LPL	lipoprotein lipase	11.0	Publications
27	GP1BA	glycoprotein Ib (platelet), alpha polypeptide	11.0	Publications
28	STAT6	signal transducer and activator of transcription 6, interleukin-4 induced	11.0	Publications
29	EDNRB	endothelin receptor type B	11.0	Publications
30	LOX	lysyl oxidase	11.0	Publications
31	FGA	fibrinogen alpha chain	11.0	Publications
32	FGB	fibrinogen beta chain	11.0	Publications
33	PGF	placental growth factor	11.0	Publications
34	NUDT6	nudix (nucleoside diphosphate linked moiety X)-type motif 6	11.0	Publications
35	APOA4	apolipoprotein A-IV	11.0	Publications
36	MTTP	microsomal triglyceride transfer protein	11.0	Publications
37	PCSK9	proprotein convertase subtilisin/kexin type 9	11.0	Publications
38	ATP2A3	ATPase, Ca++ transporting, ubiquitous	11.0	Publications
39	LPA	lipoprotein, Lp(a)	11.0	Publications
40	PIK3C2A	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha	11.0	Publications
41	NPPB	natriuretic peptide B	11.0	Publications
42	NOS3	nitric oxide synthase 3 (endothelial cell)	11.0	Publications
43	NPPA	natriuretic peptide A	11.0	Publications
44	ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	11.0	Publications
45	HBEGF	heparin-binding EGF-like growth factor	11.0	Publications
46	MB	myoglobin	11.0	Publications
47	HBG2	hemoglobin, gamma G	11.0	Publications
48	GSR	glutathione reductase	11.0	Publications
49	GNB3	guanine nucleotide binding protein (G protein), beta polypeptide 3	11.0	Publications
50	ABCA1	ATP-binding cassette, sub-family A (ABC1), member 1	11.0	Publications

Pathways related to ischemic heart disease according to GeneDecks:

(show top 50)    (show all 90)

id	Pathway	Score	Top Affiliating Genes
1	ACE Inhibitor Pathway, Pharmacodynamics34	10.9	AGTR1
2	Statin Pathway, Pharmacodynamics34	10.7	HMGCR, APOB, LPL, LIPC, MTTP, APOA1
3	Development Leptin signaling via JAK/STAT and MAPK cascades10	10.6	CRP, LEP
4	Development_Leptin signaling via JAK/STAT and MAPK cascades41	10.5	CYCS, TIMP1
5	Glioma Invasiveness36	10.4	HGF, NUDT6, FGF2, VTN, TIMP1, PGF
6	Extrinsic Prothrombin Activation Pathway36	10.4	THBD, SERPINC1, F7, FGB, FGA, F5
7	Selected targets of HNF110	10.3	SERPINA1, LPA, APOA1, APOB, INS, ALB
8	Akt Signaling36	10.2	GNB3, CXCL12, NUDT6, CSF1, PF4, PGF
9	Blood Coagulation Signaling Pathways37	9.9	F5, F3, F2, F8, GP1BA, FGB
10	Complement and coagulation cascades20	9.9	SERPINE1, FGA, FGB, MBL2, F8, F7
11	Blood Coagulation Cascade36	9.9	F13A1, F8, F3, F2, FGB, F5
12	Cell adhesion Plasmin signaling10	9.7	MAPK14, PIK3CA, VEGFA, FGA, FGB, FGF2
13	LDL Oxidation in Atherogenesis36	9.7	VCAM1, TNF, CSF1, ICAM1, CCL2, MPO
14	Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics34	9.5	ACE, AGT, AGTR1, TGFB1, KNG1, NOS3
15	Cell adhesion_ECM remodeling41	9.4	HBEGF, SERPINE1, VTN, PLAT, MMP1, MMP3
16	Cell adhesion ECM remodeling10	9.4	TIMP1, HBEGF, VTN, SERPINE1, PLAT, IGF1
17	Selected targets of GCR-alpha10	9.3	CYP3A4, ELN, HSPD1, IL6, IL1B, INSR
18	Development_VEGF signaling via VEGFR2 - generic cascades41	8.8	VCL, ITGB3, VEGFA, PIK3CA, PTGS2, PTGS1
19	Angiogenesis3	8.8	MMP9, TGFB1, NOS3, HIF1A, TIMP1, PTGS2
20	Endothelin-1 Signaling Pathway36	8.7	EDNRA, INSR, IL6, CXCL12, EDN1, PF4
21	Immune response MIF in innate immunity response10	8.6	CD14, IRAK1, IL1B, IL6, IL8, NOS2
22	Immune response_MIF in innate immunity response41	8.6	PTGS2, CD14, IRAK1, IL1B, IL6, IL8
23	Malaria20	8.5	IL6, IL1B, VCAM1, SELP, SELE, HGF
24	Rheumatoid arthritis20	8.5	TNF, TGFB1, CXCL12, CSF1, PGF, ICAM1
25	Immune response MIF-mediated glucocorticoid regulation10	8.4	PTGS2, TNF, ICAM1, NOS2, MAPK1, IL8
26	Immune response_MIF-mediated glucocorticoid regulation41	8.4	NOS2, VCAM1, MMP1, IL6, IL8, MAPK1
27	Immune response_IL-1 signaling pathway41	8.4	IL6, IL1B, IRAK1, SERPINE1, CP, EDN1
28	Immune response IL-1 signaling pathway10	8.4	EDN1, NOS2, PTGS2, TNF, HMOX1, F3
29	Molecular Mechanisms of Cancer36	8.2	FGF2, HIF1A, PF4, CYCS, HGF, GNB3
30	PPAR Pathway36	8.1	IL6, PPARA, NUDT6, FGF2, ITGB3, MAPK14
31	Activation of PKA through GPCR36	8.1	HGF, UCN, ADRB2, PGF, NUDT6, TGFB1
32	ERK Signaling36	8.0	MAPK1, INSR, IL1B, IL6, TIMP1, TGFB1
33	Pathways in cancer20	7.9	CYCS, NOS2, TGFB1, PIK3CA, MAPK1, FGF2
34	Tec Kinases Signaling36	7.8	STAT6, TGFB1, TIMP1, TNF, GNB3, IGF1
35	MIF Mediated Glucocorticoid Regulation36	7.8	IL6, HGF, CSF1, CXCL12, PF4, PTGS2
36	MIF Regulation of Innate Immune Cells36	7.8	CSF3, CD14, IL1B, IL6, IL8, MAPK1
37	p70S6K Signaling36	7.7	INS, HGF, PGF, NUDT6, TGFB1, TIMP1
38	Chagas disease (American trypanosomiasis)20	7.6	IL1B, TGFB1, ACE, NOS2, TNF, IRAK1
39	Renin-Angiotensin Pathway36	7.6	VCAM1, PTGS2, PGF, TGFB1, CXCL12, NUDT6
40	Activation of cAMP-Dependent PKA36	7.5	UCN, TNNI3, FGF2, INSR, TGFB1, IL6
41	PAK Pathway36	7.5	TGFB1, NUDT6, TIMP1, PF4, TNF, IGF1
42	p38 Signaling36	7.5	INSR, IRAK1, FGF2, PGF, CSF3, IL1B
43	Pancreatic Adenocarcinoma36	7.3	HGF, MAPK1, TGFB1, STAT6, CXCL12, NUDT6
44	mTOR Pathway36	7.2	MAPK14, TGFB1, MAPK1, IGF1, HIF1A, TIMP1
45	MAPK Signaling36	7.2	NUDT6, IL6, INSR, IRAK1, ITGB3, STAT6
46	Rho Family GTPases36	7.1	NUDT6, CXCL12, TGFB1, MAPK1, ITGB3, INSR
47	JAK-STAT Pathway36	7.0	PGF, HGF, NUDT6, CXCL12, STAT6, TGFB1
48	MAPK Family Pathway36	6.7	GNB3, FGF2, IL1B, IL2RB, IL6, TNF
49	TGF-Beta Pathway36	6.7	TIMP1, HGF, IL8, FGF2, MAPK1, CCL2
50	Antioxidant Action of Vitamin-C36	6.5	TGFB1, IL1B, FGF2, HGF, PGF, CSF3

Compounds related to ischemic heart disease according to GeneDecks:

(show top 50)    (show all 587)

id	Compound	Score	Top Affiliating Genes
1	atenolol32 9 18 9	13.6	SERPINE1, ADRB2
2	dmso32	10.4	SELP, XDH, MMP3, INSR, APOB, F3
3	egcg32	10.3	MAPK14, CAT, PTGS1, CYCS, EDNRA, TIMP1
4	malondialdehyde32	10.2	PIK3C2A, COG2, LPA, CKM, XDH, MPO
5	cholesterol ester32	10.2	COG2, LPA, LIPC, MTTP, CETP, APOA1
6	fatty acid32	10.1	PIK3C2A, COG2, CLU, LEP, MTTP, MKI67
7	palmitate32	10.1	SELE, CETP, APOA1, FABP12, PPARG, PPARA
8	enalapril32 9 9	12.0	REN, SERPINE1, APOA1, ALB, CYP3A4, PLAT
9	potassium32 9 18 9	13.0	PIK3CA, PIK3C2A, COG2, REN, VTN, KCNJ5
10	amlodipine32 9 18 9	13.0	REN, SERPINE1, VCAM1, ALB, HMGCR, CYP3A4
11	p00332	9.9	COG2, SERPINA1, SERPINE1, LIPC, LEP, CHI3L1
12	rapamycin32 42	10.9	SELL, VEGFA, KCNJ5, INS, IMPA1, IL2RB
13	vitamin a32 9 18 9	12.9	VWF, SERPINA1, LPL, LIPC, LEP, CETP
14	ezetimibe32 9 9	11.8	COG2, MTTP, CETP, INS, APOA1, APOB
15	sodium nitroprusside32	9.8	PIK3C2A, REN, VWF, KCNJ5, MB, CAT
16	valsartan32 42 9 9	12.8	REN, SELP, SERPINE1, CCL2, ALB, PPARG
17	betacarotene32	9.8	VWF, LPL, LEP, MTHFR, CETP, CD79A
18	perindopril32 34 9 9	12.8	REN, VWF, SERPINE1, VEGFA, ALB, CRP
19	l-nmma32	9.6	VCAM1, XDH, INSR, IL1RN, CAT, GHRL
20	kininogen32	9.6	REN, VWF, VTN, SELP, SERPINC1, SERPINE1
21	gnrh32	9.6	SELL, SERPINE1, LEP, MKI67, INS, CCL2
22	bezafibrate32 9 9	11.6	PIK3C2A, COG2, SERPINE1, LPA, LPL, LIPC
23	rosuvastatin32 34 9 9	12.4	COG2, CETP, INS, IL6, APOA1, APOB
24	atp32	9.4	ZNF202, PIK3CA, PIK3C2A, VTN, VCL, LIPC
25	quinacrine32 9 9	11.3	SELE, SELP, MMP1, MMP3, GSR, LOX
26	aspartate32	9.2	PIK3C2A, VTN, SELP, CETP, CD14, MMP9
27	cysteine32	9.1	VTN, SELP, SERPINA1, LPA, VCL, CLU
28	mannitol32 9 9	11.1	GCKR, SELP, VCAM1, XDH, FGF2, MB
29	phosphatidylcholine32	9.0	SELE, LPA, LPL, VCAM1, LIPC, MTTP
30	folate32	9.0	VWF, SELE, SERPINC1, LPA, VCAM1, CLU
31	h2o232	8.9	VWF, SELL, SERPINA1, LPA, CLU, LEP
32	prednisolone32 9 9	10.9	PIK3C2A, VWF, SELL, VCAM1, MPO, CD79A
33	formaldehyde32 18	9.8	VWF, SELE, SELL, SELP, MPO, CD79A
34	acth32	8.7	PIK3C2A, REN, SERPINA1, LEP, UCN, INS
35	isoproterenol32 9 9	10.6	SELL, INSR, FGF2, MAPK1, SST, NOS2
36	menadione32 9 18 9	11.5	MTHFR, XDH, IRAK1, GSR, MAPK1, IGF1
37	fenofibrate32 9 9	10.4	PIK3C2A, COG2, SELE, SELP, SERPINE1, LPA
38	epinephrine32 9 18 9	11.2	PIK3C2A, REN, VTN, SELE, SELL, SELP
39	gm-csf32	8.1	VEGFA, CD14, IL1B, IL6, IL8, CCL2
40	glutamate32	8.1	PIK3CA, VTN, CLU, KCNJ5, CKM, LEP
41	alpha tocopherol32	8.0	LPL, VCAM1, CKM, LEP, MTHFR, XDH
42	arachidonic acid32 9 18 9	10.6	PIK3CA, VWF, SELP, SERPINA1, LPL, LIPC
43	norepinephrine32 9 18 9	10.6	PIK3C2A, REN, VWF, SELE, SELL, SELP
44	alanine32	7.4	PIK3C2A, COG2, VWF, VTN, SELE, SELL
45	resveratrol32 9 18 9	10.2	PIK3CA, VEGFA, XDH, CD14, MMP9, MAPK14
46	cytochalasin d32 42	8.0	VWF, VTN, SELE, SELL, LPL, VCAM1
47	cholesterol32 9 18 9	9.9	ZNF202, PIK3CA, PIK3C2A, COG2, REN, VWF
48	thymidine32 18	7.4	PIK3CA, SERPINA1, CLU, MTHFR, MKI67, INSR
49	pdtc32	5.2	PIK3CA, GCLM, SELE, VCAM1, XDH, MMP1
50	troglitazone32 42 9 9	8.2	SELE, SERPINE1, LPL, VCAM1, LEP, MMP1

Cellular components related to ischemic heart disease according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	very-low-density lipoprotein particle	GO:034361	10.6	APOE, APOC3, APOB, APOA4, APOA1, LPL
2	high-density lipoprotein particle	GO:034364	10.5	PON1, APOE, APOA4, APOA1, CETP, LIPC
3	extracellular matrix	GO:031012	10.4	SOD1, PLAT, F3, MGP, CLU, LPL
4	chylomicron	GO:042627	10.2	APOE, APOC3, APOB, APOA4, LPL
5	external side of plasma membrane	GO:009897	10.0	IL2RB, ICAM1, TNF, ACE, CXCL12, FGB
6	cell surface	GO:009986	9.7	CYP3A4, PLAT, HBEGF, THBD, TGFB1, PROM1
7	secretory granule	GO:030141	9.3	PLAT, GHRL, HSPD1, APOA1, IL1B, INS
8	platelet alpha granule lumen	GO:031093	8.6	VWF, SERPINA1, SERPINE1, VEGFA, CLU, FGA
9	plasma membrane	GO:005886	8.4	EDNRB, EDNRA, NF2, NOS3, PTGS1, TNF
10	extracellular region	GO:005576	5.6	SERPINE1, APOA1, APOA4, APOB, APOC3, APOE
11	extracellular space	GO:005615	4.8	REN, MGP, FGA, FGB, FGF2, IL1B

Biological processes related to ischemic heart disease according to GeneDecks:

(show top 50)    (show all 58)

id	Name	GO ID	Score	Top Affiliating Genes
1	cholesterol homeostasis	GO:042632	10.9	ABCA1, APOE, APOC3, APOB, APOA4, APOA1
2	reverse cholesterol transport	GO:043691	10.9	ABCA1, APOE, APOC3, APOA4, APOA1, CETP
3	high-density lipoprotein particle remodeling	GO:034375	10.8	APOE, APOC3, APOA4, APOA1, CETP, LIPC
4	low-density lipoprotein particle remodeling	GO:034374	10.8	AGTR1, AGT, APOB, MPO, CETP, LIPC
5	positive regulation of macrophage derived foam cell differentiation	GO:010744	10.8	CSF1, AGTR1, AGT, PF4, APOB, LPL
6	cholesterol metabolic process	GO:008203	10.8	ABCA1, CAT, APOE, APOC3, APOB, APOA4
7	very-low-density lipoprotein particle remodeling	GO:034372	10.7	APOE, APOA4, CETP, LIPC, LPL
8	triglyceride metabolic process	GO:006641	10.7	CPT1A, PCSK9, LPL, CETP, APOC3, APOE
9	positive regulation of cholesterol esterification	GO:010873	10.7	AGTR1, AGT, APOE, APOA4, APOA1
10	lipoprotein metabolic process	GO:042157	10.7	LPA, PCSK9, LPL, MTTP, PPARA, ALB
11	triglyceride homeostasis	GO:070328	10.7	APOC3, APOA1, CETP, LIPC, LPL, GCKR
12	phospholipid efflux	GO:033700	10.5	APOA1, APOA4, APOC3, APOE, ABCA1
13	negative regulation of blood coagulation	GO:030195	10.5	KNG1, THBD, EDN1, APOE, SERPINE1, VTN
14	response to mechanical stimulus	GO:009612	10.4	CXCL12, CHI3L1, MMP9, MGP, CCL2, F3
15	negative regulation of macrophage derived foam cell differentiation	GO:010745	10.2	ADIPOQ, ABCA1, CRP, PPARA, PPARG, ITGB3
16	lipid metabolic process	GO:006629	10.1	LPA, ZNF202, LPL, CLU, MTTP, ALB
17	positive regulation of cellular protein metabolic process	GO:032270	10.0	ADIPOQ, CSF1, TGFB1, AGTR1, AGT, INS
18	response to lipopolysaccharide	GO:032496	10.0	PTGS2, PDE5A, EDN1, EDNRA, THBD, TRIB1
19	leukocyte tethering or rolling	GO:050901	9.9	TNF, LEP, VCAM1, SELP, SELE
20	acute-phase response	GO:006953	9.9	CRP, F2, F8, MBL2, IL6, IL1RN
21	cell surface receptor signaling pathway	GO:007166	9.9	ADRB2, NPPB, AGER, EDNRB, EDN1, SST
22	regulation of blood pressure	GO:008217	9.8	NPPB, NPPA, SOD1, ACE, EDNRB, NOS3
23	G-protein coupled receptor signaling pathway	GO:007186	9.7	SST, EDN1, EDNRA, ABCA1, AGT, AGTR1
24	positive regulation of endothelial cell proliferation	GO:001938	9.7	PGF, CXCL12, HIF1A, F3, CCL2, FGF2
25	cellular response to interleukin-1	GO:071347	9.6	HIF1A, EDN1, ICAM1, CCL2, IL8, MMP9
26	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.6	HGF, ADIPOQ, AGT, IGF1, IL6, INS
27	response to heat	GO:009408	9.5	SOD1, CXCL12, NOS3, SST, CCL2, IL1B
28	positive regulation of protein kinase B signaling cascade	GO:051897	9.4	TGFB1, HBEGF, TNF, F3, F7, IGF1
29	lipopolysaccharide-mediated signaling pathway	GO:031663	9.4	TGFB1, NOS3, TNF, CCL2, MAPK14, IL1B
30	negative regulation of apoptotic process	GO:043066	9.4	CAT, GHRL, TNF, PF4, EDNRA, TIMP1
31	response to organic cyclic compound	GO:014070	9.3	CPT1A, NPPB, NOS3, PTGS2, ICAM1, F7
32	aging	GO:007568	9.2	TGFB1, TIMP1, AGT, EDNRA, NOS3, PTGS1
33	positive regulation of angiogenesis	GO:045766	9.1	HIF1A, NOS3, HMOX1, F3, IL1B, FGF2
34	positive regulation of NF-kappaB transcription factor activity	GO:051092	9.1	TGFB1, AGT, AGER, TNF, CAT, ICAM1
35	positive regulation of apoptotic process	GO:043065	9.1	AGT, SOD1, KNG1, ADRB2, ADCY10, PDE5A
36	positive regulation of protein phosphorylation	GO:001934	9.0	ADIPOQ, TGFB1, EDNRA, TNF, F2, IL1B
37	positive regulation of nitric oxide biosynthetic process	GO:045429	9.0	INSR, IL1B, ICAM1, TNF, PTGS2, EDN1
38	response to drug	GO:042493	9.0	PPARG, NOS3, EDN1, TGFB1, SOD1, NPPB
39	response to glucocorticoid stimulus	GO:051384	9.0	ADIPOQ, PLAT, PTGS2, TNF, CCL2, IL6
40	positive regulation of smooth muscle cell proliferation	GO:048661	8.9	IGF1, HMOX1, TNF, PTGS2, EDN1, HBEGF
41	anti-apoptosis	GO:006916	8.9	GHRL, HMOX1, TNF, NOS3, SOD1, HGF
42	small molecule metabolic process	GO:044281	8.8	PTGS1, PTGS2, HMGCR, HMOX1, CAT, GNB3
43	platelet degranulation	GO:002576	8.7	ALB, F5, F8, IGF1, APOA1, FGB
44	response to estradiol stimulus	GO:032355	8.7	TGFB1, NOS3, PTGS2, F3, IL1B, INSR
45	activation of MAPK activity	GO:000187	8.5	HGF, SOD1, TNF, GHRL, MAPK1, MAPK14
46	inflammatory response	GO:006954	8.3	TNF, PTGS2, CRP, AGER, TGFB1, CSF1
47	positive regulation of cell proliferation	GO:008284	8.3	EDNRA, TIMP1, TGFB1, CSF1, CSF3, PGF
48	response to hypoxia	GO:001666	8.1	CRP, TGFB1, HIF1A, EDNRA, EDN1, PDE5A
49	platelet activation	GO:030168	7.2	KNG1, SOD1, TGFB1, TIMP1, PF4, TMSB4X
50	blood coagulation	GO:007596	7.0	PIK3CA, F13A1, ALB, F2, F3, F5

Molecular functions related to ischemic heart disease according to GeneDecks:

(show all 10)

id	Name	GO ID	Score	Top Affiliating Genes
1	cholesterol transporter activity	GO:017127	10.6	CETP, APOA1, APOA4, APOB, ABCA1
2	eukaryotic cell surface binding	GO:043499	10.0	ADIPOQ, TGFB1, HBEGF, MBL2, APOA4, FGB
3	heparin binding	GO:008201	10.0	VTN, KNG1, PGF, SOD3, HBEGF, PF4
4	protease binding	GO:002020	9.8	TNF, F3, INS, SERPINE1, SERPINA1, SERPINC1
5	receptor binding	GO:005102	9.8	CAT, NOS2, CXCL12, NPPA, NPPB, KNG1
6	heme binding	GO:020037	9.3	HBG2, NOS3, NOS2, CYCS, CYP2C19, CYP3A4
7	hormone activity	GO:005179	9.0	ADIPOQ, NPPB, NPPA, AGT, EDN1, SST
8	protein homodimerization activity	GO:042803	8.6	CRP, NOS2, SHBG, TGFB1, SOD1, CSF1
9	growth factor activity	GO:008083	8.0	TGFB1, CXCL12, NUDT6, CSF1, CSF3, PGF
10	protein binding	GO:005515	4.1	CYCS, PPARG, PPARA, CRP, PLAT, NOS2