IHD
MCID: ISC006
MIFTS: 62

Ischemic Heart Disease (IHD) malady

Cardiovascular category

Summaries for Ischemic Heart Disease

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
See all sources

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Wikipedia:64 Coronary artery disease (CAD) also known as atherosclerotic heart disease,coronary heart disease, or... more...

MalaCards: Ischemic Heart Disease, also known as myocardial ischemia, is related to coronary heart disease and stroke, ischemic. An important gene associated with Ischemic Heart Disease is F7 (coagulation factor VII (serum prothrombin conversion accelerator)), and among its related pathways are Selenium Pathway and Platelet activation, signaling and aggregation. The compounds lipid and cholesterol have been mentioned in the context of this disorder. Related mouse phenotypes are homeostasis/metabolism and cardiovascular system.

Disease Ontology:8 An extrinsic cardiomyopathy that is characterized by reduced blood supply to the cardiac muscles.

Aliases & Classifications for Ischemic Heart Disease

Sources:
61UMLS, 8Disease Ontology, 10DISEASES, 31LifeMap Discovery™, 45Novoseek, 39NCBI Bookshelf, 57SNOMED-CT, 35MeSH, 40NCIt, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular


Aliases & Descriptions:

ischemic heart disease 8 10 31
myocardial ischemia 8 45 61
chronic myocardial ischaemia 8
coronary arteriosclerosis 61
ihd 39


Related Diseases for Ischemic Heart Disease

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Ischemic Heart Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 219)
idRelated DiseaseScoreTop Affiliating Genes
1coronary heart disease31.4TNNI3, ACE, F7, PF4, CRP, LPL
2stroke, ischemic31.1APOA1, APOB, CRP, F7, ACE
3vascular disease30.9APOA1, APOB, LPL, CRP, F7, ACE
4atherosclerosis30.9APOA1, APOB, FABP12, LPXN, LPL, CRP
5hypercholesterolemia30.8APOA1, APOB, LPXN, LPL, CRP, F7
6coronary artery disease,30.7KCNJ5, APOA1, APOB, NPPB, LPL, CRP
7arthritis30.6CRP
8arteriosclerosis30.5APOA1, APOB, LPL
9insulin resistance30.4APOA1, APOB, FABP12, LPL, CRP, F7
10kawasaki disease30.4CRP, NPPB
11acute myocardial infarction30.3KCNJ5, TNNI3, APOA1, APOB, NPPB, FABP12
12peripheral vascular disease30.3APOA1, APOB, PF4, ACE
13thromboembolism30.3APOA1, PF4, F7
14hyperlipidemia type 330.3APOA1, APOB, LPL
15hyperuricemia30.3APOB
16hyperhomocysteinemia30.1CRP
17amyloidosis30.1CRP, LPL, NPPB, APOA1
18familial hypercholesterolemia30.1APOA1, APOB, LPL
19carotid stenosis30.1CRP
20aortic aneurysm30.1CRP
21osteoarthritis30.1CRP, UCN
22lipoprotein lipase deficiency30.1LPL
23nephritis30.1ACE
24asthma30.0UCN
25lip disease10.9
26cardiovascular disease risk factor10.5
27hypertensive heart disease10.5
28aortic disease10.5
29brain ischemia10.5
30brain disease10.4
31heart tumor10.4
32sleep apnea10.4
33vaccinia10.3
34coronary thrombosis10.3
35n syndrome10.3
36aortic valve disease10.3
37myocardial stunning10.3
38left ventricular outflow tract obstruction10.3
39angina pectoris10.2
40ischemic retinopathy10.2
41diabetic nephropathy10.2
42chronic angina10.2
43arteriosclerosis obliterans10.2
44celiac disease10.2
45systolic heart failure10.2
46adult syndrome10.2
47bronchogenic cyst10.2
48hypoxia10.2
49syncope10.2
50venous thromboembolism10.2

Graphical network of the top 20 diseases related to Ischemic Heart Disease:



Diseases related to ischemic heart disease

Clinical Features for Ischemic Heart Disease

Drugs & Therapeutics for Ischemic Heart Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Ischemic Heart Disease

Drug clinical trials:

Search ClinicalTrials for Ischemic Heart Disease

Search NIH Clinical Center for Ischemic Heart Disease

Search CenterWatch for Ischemic Heart Disease

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Ischemic Heart Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Ischemic Heart Disease:
ACT34-CMI, bone marrow-derived cells for ischemic heart diseases
Adipocell
Adipose-derived mesenchymal stromal stem cells for ischemic heart disease
ADRCs, adipose-derived regenerative cells for treatment of cardiovascular disease
AMDC, autologous muscle-derived cells for ischemic heart failure
Autologous bone marrow-derived mesenchymal stem cells for treatment of heart muscle damage
Bone marrow-derived CD133+ stem cells for treatment of ischemic heart disease
Bone marrow-derived mesenchymal stem cells for treatment of heart diseases
Bone marrow-derived mesenchymal stem cells for treatment of ischemic heart disease
Bone marrow-derived mononuclear cells for ischemic cardiomyopathy
Bone marrow-derived mononucleated cells for heart disease
Bone marrow-derived stem cells for treatment of chronic ischemic heart failure
Bone marrow-derived stem cells for treatment of ischemic cardiomyopathy
Bone marrow-derived stem cells for treatment of severe chronic ischemic heart disease
Cardiac stem cells for treatment of ischemic cardiomyopathy
Cardiocell
Combination therapy of mononuclear cells with laser for coronary disease
Embryonic stem cell-derived cardiomyocytes for ischemic myocardium
Enriched bone marrow-derived progenitor cells for heart diseases
Mesendo, stem cell combination for treatment of cardiovascular diseases
Peripheral mononuclear cells CD34+ stem cells for treatment of myocardial ischemia
Peripheral or bone marrow-derived stem cells for chronic heart failure
StempeucelICM
Embryonic/Adult Cultured Cells Related to Ischemic Heart Disease:
Bone marrow-derived CD34+ stem cells (ACT34), PMIDs: 11283669, 12551872, 22163120, 20448213, 9020076, 17562958, 21737787
VEGF-A165-stimulated ADSCs
Adipose-derived stem and regenerative cell, PMIDs: 21082397, 22281257
Autologous muscle-derived cells
Bone marrow-derived mesenchymal stem cells (family)
Bone marrow-derived CD133+ cells
Bone marrow-derived mesenchymal stem cells , PMID: 22940024
Bone marrow-derived mesenchymal stem cells (family), PMIDs: 21052537, 19591227
Bone marrow-derived hematopoietic stem cells (family)
Bone marrow-derived stem cells
Bone marrow-derived mesenchymal stem cells , PMIDs: 21392602, 22940024
Bone marrow-derived mononuclear cells (family), PMIDs: 21392602, 22940024
Porcine bone marrow-derived mesenchymal stem cells, PMIDs: 21392602, 22940024
Human cardiac stem cells, PMIDs: 22088800, 22965994
Bone marrow-derived mesenchymal stem cells (family)
Bone marrow-derived mononuclear cells (family)
Cardiomyocyte-like cells, PMID: 18941512
Bone marrow-derived progenitor cells, PMIDs: 23362308, 22936827, 18794392, 16990384, 16990385, 22651868
Bone marrow-derived mononuclear cells, PMIDs: 21323410, 20631864
Bone marrow-derived mesenchymal stem cells, PMIDs: 21323410, 20631864
Peripheral blood-derived hematopoietic stem cells (family)
Bone marrow-derived mononuclear cells, PMIDs: 20668107, 21596713, 19761394, 22834565
Bone marrow-derived mesenchymal stem cells (Stempeucel, PMID: 18720444

Genetic Tests for Ischemic Heart Disease

Anatomical Context for Ischemic Heart Disease

Sources:
31LifeMap Discovery™
See all sources

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Ischemic Heart Disease:
id TissueAnatomical CompartmentCell Relevance
1 LimbPelvic GirdleBone Marrow Stromal Cells Potential therapeutic candidate
2 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate

Animal Models for Ischemic Heart Disease or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Ischemic Heart Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537610.9APOA1, APOB, LPL, CRP, ZC3H12A, PF4
2MP:000538510.5ACE, KCNJ5, TNNI3, APOA1, APOB, NPPB

Publications for Ischemic Heart Disease

Sources:
51PubMed
See all sources

Articles related to Ischemic Heart Disease:

(show top 50)    (show all 840)
idTitleAuthorsYear
1
Association of I^-Blocker Therapy With Risks of Adverse Cardiovascular Events and Deaths in Patients With Ischemic Heart Disease Undergoing Noncardiac Surgery: A Danish Nationwide Cohort Study. (24247428)
2013
2
Guideline stresses medical therapy for treating stable ischemic heart disease. (23321742)
2013
3
Associations of adiponectin and leptin with incident coronary heart disease and ischemic stroke in african americans: the jackson heart study. (24350185)
2013
4
Probenecid as a noninjurious positive inotrope in an ischemic heart disease murine model. (23241275)
2013
5
Short-term effects of ivabradine in patients with chronic stable ischemic heart disease. (23983908)
2013
6
Silent ischemic heart disease and pericardial fat volume in HIV-infected patients: a case-control myocardial perfusion scintigraphy study. (23967275)
2013
7
Cross-cultural analysis of Type D (distressed) personality in 6222 patients with ischemic heart disease: a study from the International HeartQoL Project. (22078395)
2013
8
Determinants of cardiovascular mortality in a cohort of primary care patients with chronic ischemic heart disease. BARBANZA Ischemic Heart Disease (BARIHD) study. (22305776)
2013
9
Adult height and risk of ischemic heart disease, atrial fibrillation, stroke, venous thromboembolism, and premature death: a population based 36-year follow-up study. (24337942)
2013
10
Exercise mediates the association between positive affect and 5-year mortality in patients with ischemic heart disease. (24021694)
2013
11
Ischemic heart disease in patients undergoing dialysis. (23299034)
2012
12
Construction of PR39 recombinant AAV under control of the HRE promoter and the effect of recombinant AAV on gene therapy of ischemic heart disease. (23226731)
2012
13
Homocysteine is related to aortic mineralization in patients with ischemic heart disease. (22240908)
2012
14
Assessing the global burden of ischemic heart disease, part 2: analytic methods and estimates of the global epidemiology of ischemic heart disease in 2010. (23505617)
2012
15
Short telomere length, myocardial infarction, ischemic heart disease, and early death. (22199369)
2012
16
Towns with extremely low mortality due to ischemic heart disease in Spain. (22404881)
2012
17
Intra coronary freshly isolated bone marrow cells transplantation improve cardiac function in patients with ischemic heart disease. (22534049)
2012
18
Nonfasting glucose, ischemic heart disease, and myocardial infarction: a Mendelian randomization study. (22698489)
2012
19
Mental stress and ischemic heart disease: evolving awareness of a complex association. (21627481)
2011
20
Intraoperative diagnosis of bilateral coronary ostia stenosis: a rare case of ischemic heart disease in a 3-month-old patient. (22051282)
2011
21
Plasma YKL-40 in relation to the degree of coronary artery disease in patients with stable ischemic heart disease. (21827355)
2011
22
Factors determining clinical effectiveness of clopidogrel and prognosis of patients with stable ischemic heart disease]. (21627593)
2011
23
Report of the third International Society for Holter and Noninvasive Electrocardiology working group on improved electrocardiographic criteria for acute and chronic ischemic heart disease--Lund, Sweden: June 2010. (21168008)
2011
24
Optimizing stem cell function for the treatment of ischemic heart disease. (20828719)
2011
25
Histamine blood concentration in ischemic heart disease patients. (21687546)
2011
26
Nationwide cohort study of risk of ischemic heart disease in patients with celiac disease. (21262996)
2011
27
Psychological well-being in obese inpatients with ischemic heart disease at entry and at discharge from a four-week cardiac rehabilitation program. (21833207)
2010
28
MCP-1 -2518 A/G gene polymorphism is associated with blood pressure in ischemic heart disease asymptomatic subjects. (21033620)
2010
29
Effect of diabetes on the clinical characteristics and prognosis of patients with chronic ischemic heart disease. The CIBAR study. (21070733)
2010
30
Images in cardiovascular medicine: Perfusion cardiovascular magnetic resonance in a child with ischemic heart disease: potential advantages over nuclear medicine. (20644027)
2010
31
Clarithromycin use and risk of death in patients with ischemic heart disease. (20523043)
2010
32
Prevalence of the metabolic syndrome diagnosed using three different definitions and risk of ischemic heart disease among Kaunas adult population. (20234165)
2010
33
Beyond coronary artery disease: rosuvastatin in older patients with ischemic systolic heart failure. (18774975)
2008
34
Elevated plasma brain natriuretic peptide levels independent of heart disease in acute ischemic stroke: correlation with stroke severity. (18971547)
2008
35
Correlation of C-reactive protein with echocardiographic parameters of hypertrophic and ischemic heart disease in patients on regular hemodialyses]. (18928185)
2007
36
Effect of short-term treatment with pravastatin on cytokines and cytokine receptors in patients with chronic heart failure due to ischemic and nonischemic disease. (16102449)
2005
37
C-reactive protein, fibrin D-dimer, and risk of ischemic heart disease: the Caerphilly and Speedwell studies. (15308549)
2004
38
Ischemic heart disease induces upregulation of endothelin receptor mRNA in human coronary arteries. (14729387)
2004
39
Methylenetetrahydrofolate reductase polymorphism (C677T), hyperhomocysteinemia, and risk of ischemic cardiovascular disease and venous thromboembolism: prospective and case-control studies from the Copenhagen City Heart Study. (15226189)
2004
40
Repair versus replacement for degenerative mitral valve disease with coexisting ischemic heart disease. (12830055)
2003
41
Angiotensinogen gene polymorphism, plasma angiotensinogen, and risk of hypertension and ischemic heart disease: a meta-analysis. (12805070)
2003
42
Gilbert syndrome and ischemic heart disease: a protective effect of elevated bilirubin levels. (11849670)
2002
43
Evaluation of alcoholic intoxication depending of the level of brain ethanol-metabolizing enzymes in death from ischemic heart disease]. (11561510)
2001
44
C-reactive protein, fibrin D-dimer, and incident ischemic heart disease in the Speedwell study: are inflammation and fibrin turnover linked in pathogenesis? (11304479)
2001
45
Polymorphic markers of endothelial NO-synthase and angiotensin II vascular receptor genes and predisposition to ischemic heart disease]. (11190479)
2000
46
Efficacy and safety of sildenafil citrate in the treatment of erectile dysfunction in patients with ischemic heart disease. (10078540)
1999
47
Effect of low-dose heparin on fibrinogen levels in patients with chronic ischemic heart disease. (9801927)
1998
48
Relations between the levels of lipoprotein-containing immune complexes and lipids in the blood of patients with ischemic heart disease]. (2041289)
1991
49
The phosphate and methemoglobin content of the erythrocytes in patients with ischemic heart disease]. (2042338)
1991
50
Left ventricular remodeling and ischemic heart diseases. Therapeutic possibilities]. (1686544)
1991

Genetic Variations for Ischemic Heart Disease

Expression for genes affiliated with Ischemic Heart Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Ischemic Heart Disease

Search GEO for disease gene expression data for Ischemic Heart Disease.

Pathways for genes affiliated with Ischemic Heart Disease

Sources:
38NCBI BioSystems Database, 54Reactome, 12EMD Millipore, 50PharmGKB
See all sources

Compounds for genes affiliated with Ischemic Heart Disease

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 60Tocris Bioscience
See all sources

Compounds related to Ischemic Heart Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 111)
idCompoundScoreTop Affiliating Genes
1lipid4511.4KCNJ5, FABP12, NPPB, LPXN, APOB, ZNF202
2cholesterol45 29 11 2414.3ACE, ZNF202, F7, PF4, APOB, LPL
3lactate4511.3CRP, FABP12, APOB, APOA1, KCNJ5, PF4
4creatinine4511.3F7, APOA1, TNNI3, ACE, APOB, NPPB
5acetylcholine45 50 29 11 2415.2PF4, ACE, UCN, KCNJ5, CRP, LPL
6glucose4511.2UCN, KCNJ5, APOA1, NPPB, LPXN, LPL
7aspirin45 50 29 2414.1APOB, NPPB, CRP, PF4, APOA1, ACE
8kininogen4511.1ACE, APOA1, APOB, PF4, F7
9metformin45 50 1113.1CRP, ACE, APOB, APOA1, LPL
10pioglitazone45 50 29 1114.1NPPB, LPL, CRP, APOB, APOA1
11atorvastatin45 50 29 11 2415.1NPPB, APOA1, APOB, CRP, LPL
12carnitine4511.1APOA1, APOB, FABP12, LPL, CRP
13calcium45 50 11 2414.1KCNJ5, F7, PF4, ACE, CRP, FABP12
14atenolol45 29 50 11 2415.1NPPB, CRP, ACE, APOA1
15prostacyclin4511.1NPPB, CRP, APOA1, ACE, PF4
16nitroglycerin45 1112.1KCNJ5, ACE, CRP, NPPB
17bezafibrate45 29 1113.0CRP, APOA1, LPL, APOB
18fenofibrate45 50 1113.0LPL, CRP, APOB, APOA1
19vitamin a45 11 2413.0APOB, FABP12, APOA1, CRP, LPL
20dextran sulfate4511.0APOB, PF4, APOA1, LPL
21norepinephrine45 11 2413.0LPL, UCN, KCNJ5
22fluvastatin45 50 29 1114.0APOA1, APOB, LPL, CRP
23prostaglandin f2alpha4511.0FABP12, LPL, CRP, UCN
24fosinopril45 1112.0NPPB, ACE, CRP
25fenofibric acid45 2912.0LPL, APOB, APOA1
26triacylglycerol4511.0APOA1, APOB, FABP12, LPL
27pravastatin45 50 29 11 2415.0CRP, APOB, NPPB, APOA1
28ciprofibrate45 2912.0APOA1, APOB, LPL
29retinyl palmitate45 2412.0APOA1, APOB, LPL
30uric acid45 2411.9NPPB
31tirofiban45 1111.9PF4, CRP, NPPB
32ramipril45 1111.9ACE, NPPB, CRP
33intralipid4510.9LPL, APOB, APOA1
34indomethacin45 60 29 1113.9APOA1, PF4, KCNJ5, NPPB, LPL
35valsartan45 60 29 1113.9NPPB, ACE, CRP
36doxazosin45 1111.9APOA1, LPL, ACE
37warfarin45 50 11 2413.9PF4
38perindopril45 50 1112.9ACE, NPPB, CRP
39telmisartan45 29 1112.9NPPB, CRP, ACE
40tibolone4510.9APOB, APOA1, CRP
41adenylate4510.9PF4, LPL, APOB, UCN, KCNJ5, IMPA1
42cilostazol45 1111.8PF4, NPPB
43probucol45 1111.8LPL, APOB, APOA1
44alpha tocopherol4510.7LPL
45polyethylene glycol 60004510.7APOB, APOA1
46maxepa4510.6APOA1, APOB
47levonorgestrel45 60 29 1113.6APOB, F7, APOA1
48homocysteine45 2411.5APOA1, CRP, NPPB, APOB
49palmitate4510.5FABP12
50hydrochlorothiazide45 50 29 11 2414.3CRP, ACE, APOA1

GO Terms for genes affiliated with Ischemic Heart Disease

Sources:
16Gene Ontology
See all sources

Cellular components related to Ischemic Heart Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.9ACE, APOA1, APOB, NPPB, LPL, CRP
2extracellular regionGO:00557610.8UCN, APOA1, APOB, NPPB, LPL, CRP
3endocytic vesicle lumenGO:07168210.6APOB, APOA1
4very-low-density lipoprotein particleGO:03436110.5APOA1, APOB, LPL
5chylomicronGO:04262710.3LPL, APOB

Biological processes related to Ischemic Heart Disease according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of macrophage derived foam cell differentiationGO:01074410.8PF4, LPL, APOB
2lipoprotein metabolic processGO:04215710.8LPL, APOB, APOA1
3retinoid metabolic processGO:00152310.7LPL, APOB, APOA1
4lipoprotein biosynthetic processGO:04215810.7APOA1, APOB
5positive regulation of cholesterol storageGO:01088610.6APOB, LPL
6cholesterol transportGO:03030110.6APOB, APOA1
7positive regulation of lipid storageGO:01088410.6APOB, ZC3H12A
8regulation of vasodilationGO:04231210.5ACE, NPPB
9phototransduction, visible lightGO:00760310.3LPL, APOB, APOA1

Molecular functions related to Ischemic Heart Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cholesterol transporter activityGO:01712710.6APOB, APOA1
2receptor bindingGO:00510210.3IL27, F7, LPL, NPPB

Products for genes affiliated with Ischemic Heart Disease

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Ischemic Heart Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet