IHD
MCID: ISC006
MIFTS: 58

Ischemic Heart Disease (IHD) malady

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Summaries for Ischemic Heart Disease

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Wikipedia:65 Coronary artery disease (CAD) also known as atherosclerotic heart disease,atherosclerotic cardiovascular... more...

MalaCards based summary: Ischemic Heart Disease, also known as coronary arteriosclerosis, is related to hyperlipidemia type 3 and arteriosclerosis. An important gene associated with Ischemic Heart Disease is ZNF202 (zinc finger protein 202), and among its related pathways are Cholesterol and Sphingolipids transport Recycling to plasma membrane in lung normal and CF and Selected targets of HNF1. The compounds polyethylene glycol 6000 and maxepa have been mentioned in the context of this disorder. Affiliated tissues include heart, bone and endothelial, and related mouse phenotypes are immune system and cardiovascular system.

Aliases & Classifications for Ischemic Heart Disease

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Ischemic Heart Disease, Aliases & Descriptions:

Name: Ischemic Heart Disease 30 10
Coronary Arteriosclerosis 62
 
Myocardial Ischemia 62
Ihd 38


Related Diseases for Ischemic Heart Disease

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Diseases related to Ischemic Heart Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 131)
idRelated DiseaseScoreTop Affiliating Genes
1hyperlipidemia type 330.7APOB, APOA1
2arteriosclerosis30.7APOA1, APOB
3kawasaki disease30.6CRP, NPPB
4spondylitis30.6CHI3L1
5thromboembolism30.5F7, APOA1
6coronary stenosis30.5APOA1, APOB
7cerebrovascular disease30.5ACE, APOB, APOA1
8hypertension30.3APOB, CRP, ACE, APOA1, NPPB
9hypercholesterolemia30.3F7, CRP, APOA1, APOB, ACE
10hypertensive heart disease30.3NPPB, ACE
11familial hypercholesterolemia30.3APOA4, APOA1, APOB
12peripheral vascular disease30.3APOB, ACE, APOA1
13diabetic nephropathy30.2APOB, APOA1, ACE
14amyloidosis30.1NPPB, APOA1, CRP
15obesity30.1CRP, KCNJ5, APOA4, APOA1, F7, APOB
16atherosclerosis29.8APOA4, APOA1, APOB, F7, CRP, CHI3L1
17insulin resistance29.7ACE, APOB, APOA1, CRP, APOA4, F7
18myocardial infarction29.6APOA1, F7, NPPB, CRP, ACE, APOB
19essential hypertension29.6NPPB, APOB, ACE, APOA1
20type 2 diabetes mellitus29.6APOA1, APOA4, ACE, KCNJ5, CRP, APOB
21vascular disease29.5F7, CRP, APOA4, APOA1, ACE, APOB
22diabetes mellitus29.5APOA1, ACE, APOA4, APOB, CRP, F7
23acute myocardial infarction29.0APOB, APOA1, ACE, F7, NPPB, KCNJ5
24coronary artery anomaly28.9ACE, CRP, NPPB, F7, APOA1, APOB
25endotheliitis10.6
26chylomicron retention disease10.5APOB
27breast cancer10.5
28ischemia10.5
29pelvic inflammatory disease10.5CRP
30cerebral atherosclerosis10.5APOA1
31influenza10.4
32spiradenoma10.4CRP
33vaccinia10.4
34arthritis10.3
35rheumatoid arthritis10.3
36sleep apnea10.3
37hyperalphalipoproteinemia10.3APOA1, APOB
38hypoalphalipoproteinemia10.3APOB, APOA1
39arcus senilis10.3APOB, APOA1
40familial combined hyperlipidemia10.3APOB, APOA1
41norum disease10.3APOB, APOA1
42familial hypertriglyceridemia10.3APOB, APOA1
43hypobetalipoproteinemia10.3APOA1, APOB
44congestive heart failure10.3
45dilated cardiomyopathy10.3
46obstructive sleep apnea10.3
47wegener's granulomatosis10.3
48pneumonia10.3
49amyloidosis, secondary10.3APOA1, CRP
50abetalipoproteinemia10.3APOB, APOA1

Graphical network of the top 20 diseases related to Ischemic Heart Disease:



Diseases related to ischemic heart disease

Symptoms for Ischemic Heart Disease

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Drugs & Therapeutics for Ischemic Heart Disease

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Drug clinical trials:

Search ClinicalTrials for Ischemic Heart Disease

Search NIH Clinical Center for Ischemic Heart Disease

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Ischemic Heart Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Ischemic Heart Disease:
ACT34-CMI, bone marrow-derived cells for ischemic heart diseases
Adipocell
Adipose-derived mesenchymal stromal stem cells for ischemic heart disease
ADRCs, adipose-derived regenerative cells for treatment of cardiovascular disease
AMDC, autologous muscle-derived cells for ischemic heart failure
Autologous bone marrow-derived mesenchymal stem cells for treatment of heart muscle damage
Bone marrow-derived CD133+ stem cells for treatment of ischemic heart disease
Bone marrow-derived mesenchymal stem cells for treatment of heart diseases
Bone marrow-derived mesenchymal stem cells for treatment of ischemic heart disease
Bone marrow-derived mononuclear cells for ischemic cardiomyopathy
Bone marrow-derived mononucleated cells for heart disease
Bone marrow-derived stem cells for treatment of chronic ischemic heart failure
Bone marrow-derived stem cells for treatment of ischemic cardiomyopathy
Bone marrow-derived stem cells for treatment of severe chronic ischemic heart disease
Cardiac stem cells for treatment of ischemic cardiomyopathy
Cardiocell
CD34+ stem cells for treatment of congestive heart failure
Combination therapy of mononuclear cells with laser for coronary disease
Embryonic stem cell-derived cardiomyocytes for ischemic myocardium
Enriched bone marrow-derived progenitor cells for heart diseases
Mesendo, stem cell combination for treatment of cardiovascular diseases
Peripheral mononuclear cells CD34+ stem cells for treatment of myocardial ischemia
Peripheral or bone marrow-derived stem cells for chronic heart failure
StempeucelICM
Embryonic/Adult Cultured Cells Related to Ischemic Heart Disease:
Bone marrow-derived CD34+ stem cells (ACT34), PMIDs: 11283669, 12551872, 22163120, 20448213, 9020076, 17562958, 21737787
VEGF-A165-stimulated ADSCs
Adipose-derived stem and regenerative cell, PMIDs: 21082397, 22281257
Autologous muscle-derived cells
Bone marrow-derived mesenchymal stem cells (family)
Bone marrow-derived CD133+ cells
Bone marrow-derived mesenchymal stem cells , PMID: 22940024
Bone marrow-derived mesenchymal stem cells (family), PMIDs: 21052537, 19591227
Bone marrow-derived hematopoietic stem cells (family)
Bone marrow-derived stem cells
Bone marrow-derived mesenchymal stem cells , PMIDs: 21392602, 22940024
Bone marrow-derived mononuclear cells (family), PMIDs: 21392602, 22940024
Porcine bone marrow-derived mesenchymal stem cells, PMIDs: 21392602, 22940024
Human cardiac stem cells, PMIDs: 22088800, 22965994
Bone marrow-derived mesenchymal stem cells (family)
Bone marrow-derived hematopoietic stem cells (family), PMID: 22163120
Bone marrow-derived mononuclear cells (family)
Cardiomyocyte-like cells, PMID: 18941512
Bone marrow-derived progenitor cells, PMIDs: 23362308, 22936827, 18794392, 16990384, 16990385, 22651868
Bone marrow-derived mononuclear cells, PMIDs: 21323410, 20631864
Bone marrow-derived mesenchymal stem cells, PMIDs: 21323410, 20631864
Peripheral blood-derived hematopoietic stem cells (family)
Bone marrow-derived mononuclear cells, PMIDs: 20668107, 21596713, 19761394, 22834565
Bone marrow-derived mesenchymal stem cells (Stempeucel, PMID: 18720444

Genetic Tests for Ischemic Heart Disease

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Anatomical Context for Ischemic Heart Disease

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MalaCards organs/tissues related to Ischemic Heart Disease:

32
Heart, Bone, Endothelial, Bone marrow, Testes, Breast, Brain, Lung, Prostate, Eye, Spinal cord, Placenta, Neutrophil

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Ischemic Heart Disease:
id TissueAnatomical CompartmentCell Relevance
1 LimbPelvic GirdleBone Marrow Stromal Cells Potential therapeutic candidate
2 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate

Animal Models for Ischemic Heart Disease or affiliated genes

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MGI Mouse Phenotypes related to Ischemic Heart Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.6APOA1, CHI3L1, ACE, CRP, TRIB1, APOA4
2MP:00053857.2F7, KCNJ5, APOA4, APOA1, APOB, ACE
3MP:00053767.1APOA4, APOA1, APOB, ACE, CRP, GCLM

Publications for Ischemic Heart Disease

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Articles related to Ischemic Heart Disease:

(show top 50)    (show all 811)
idTitleAuthorsYear
1
Incident ischemic heart disease and recent occupational exposure to particulate matter in an aluminum cohort. (23982120)
2014
2
Update on Ischemic Heart Disease and Critical Care Cardiology. (24412103)
2014
3
Ischemic heart disease risk factors in lead exposed workers: research study. (23607481)
2013
4
Assessment of high on-treatment platelet reactivity in patients with ischemic heart disease: concordance between the Multiplate and VerifyNow assays. (23253198)
2013
5
Pseudoxanthoma elasticum and ischemic heart disease. (23611493)
2013
6
Ischemic heart disease after breast cancer radiotherapy. (23802526)
2013
7
Ischemic heart disease in women. (23820324)
2013
8
ABSORB II randomized controlled trial: a clinical evaluation to compare the safety, efficacy, and performance of the Absorb everolimus-eluting bioresorbable vascular scaffold system against the XIENCE everolimus-eluting coronary stent system in the treatment of subjects with ischemic heart disease caused by de novo native coronary artery lesions: rationale and study design. (23137495)
2012
9
Complex biphasic relationship between epicardial fat and ischemic heart disease. (22850244)
2012
10
Mobile radiofrequency does not interfere with antiarrhythmic drugs in patients with ischemic heart disease. (23112972)
2012
11
Relationship of self-reported exercise tolerance with inflammatory markers in women with stable ischemic heart disease. (23183510)
2012
12
Aspirin resistance and ischemic heart disease on Iranian experience. (23210092)
2012
13
Impact of metabolic syndrome on ischemic heart disease - a prospective cohort study in an Iranian adult population: Isfahan Cohort Study. (21195593)
2012
14
Ischemic heart disease in patients undergoing dialysis. (23299034)
2012
15
Ancient Theory about Public Health through Physical Activity against Hyperlipidemia and Ischemic Heart Disease. (23304669)
2012
16
Right ventricular ejection fraction measured by multigated planar equilibrium radionuclide ventriculography is an independent prognostic factor in patients with ischemic heart disease. (22932818)
2012
17
Mental stress and ischemic heart disease: evolving awareness of a complex association. (21627481)
2011
18
Glutamine is cardioprotective in patients with ischemic heart disease following cardiopulmonary bypass. (22167767)
2011
19
Continuous intravenous infusion of prostaglandin E1 improves myocardial perfusion reserve in patients with ischemic heart disease assessed by positron emission tomography: a pilot study. (21461596)
2011
20
Clinical role of the Duke Activity Status Index in the selection of the optimal type of stress myocardial perfusion imaging study in patients with known or suspected ischemic heart disease. (21971704)
2011
21
Dementia and depression with ischemic heart disease: a population-based longitudinal study comparing interventional approaches to medical management. (21387018)
2011
22
Erectile dysfunction, depression, and ischemic heart disease: does the existence of one component of this triad necessitate inquiring the other two? (21457466)
2011
23
Intraoperative diagnosis of bilateral coronary ostia stenosis: a rare case of ischemic heart disease in a 3-month-old patient. (22051282)
2011
24
The Magnitude of Mortality from Ischemic Heart Disease Attributed to Occupational Factors in Korea - Attributable Fraction Estimation Using Meta-analysis. (22953190)
2011
25
Women have less severe and extensive coronary atherosclerosis in fatal cases of ischemic heart disease: an autopsy study. (21473966)
2011
26
Agreement of left ventricular mass in steady state free precession and delayed enhancement MR images: implications for quantification of fibrosis in congenital and ischemic heart disease. (20096134)
2010
27
Validation of physician billing and hospitalization data to identify patients with ischemic heart disease using data from the Electronic Medical Record Administrative data Linked Database (EMRALD). (20847968)
2010
28
Is the demand-control model still a usefull tool to assess work-related psychosocial risk for ischemic heart disease? Results from 14 year follow up in the Copenhagen City Heart study. (20971698)
2010
29
Ischemic heart disease in women: many questions, few facts. (20160161)
2010
30
Exercise training in patients with ischemic heart disease works but more high-quality studies are wanted ... (20653927)
2010
31
Genetic vulnerability and phenotypic expression of depression and risk for ischemic heart disease in the Vietnam era twin study of aging. (20190130)
2010
32
CD14 C-260T gene polymorphism and ischemic heart disease susceptibility: a HuGE review and meta-analysis. (19346955)
2009
33
Systematic review: comparative effectiveness of angiotensin-converting enzyme inhibitors or angiotensin II-receptor blockers for ischemic heart disease. (20008762)
2009
34
The influence of simvastatin on hsCRP and some paramneters of hemostasis in patients with ischemic heart disease]. (18663903)
2008
35
Comparative assessment of antiinflammatory action of atorvastatin in ischemic heart disease and rheumatoid arthritis]. (18991814)
2008
36
Immunoglobulin E in patients with ischemic heart disease. (18651396)
2008
37
Functional promoter variant in zinc finger protein 202 predicts severe atherosclerosis and ischemic heart disease. (18652945)
2008
38
An application of the patient rule-induction method for evaluating the contribution of the Apolipoprotein E and Lipoprotein Lipase genes to predicting ischemic heart disease. (17436307)
2007
39
Neoangiogenesis and coronary atherosclerosis: diagnostic value of a novel biochemical marker placenta growth factor in patients with ischemic heart disease]. (17159877)
2006
40
Oxidized LDL and lipids as risk factors for ischemic heart disease in type 2 diabetes]. (16171015)
2005
41
Correlation of high-sensitivity CRP concentration with the extent of coronary atherosclerosis in men with symptoms of ischemic heart disease]. (16161944)
2005
42
Antioxidant action and therapeutic efficacy of laser irradiation of blood in patients with ischemic heart disease]. (12852010)
2003
43
Clinical use of C-reactive protein for the prognostic stratification of patients with ischemic heart disease. (11305527)
2001
44
The expanding role of HMG-CoA reductase inhibitors (statins) in the prevention and treatment of ischemic heart disease. (11743453)
2001
45
Polymorphic markers of endothelial NO-synthase and angiotensin II vascular receptor genes and predisposition to ischemic heart disease]. (11190479)
2000
46
Association of mutations in the apolipoprotein B gene with hypercholesterolemia and the risk of ischemic heart disease. (9867529)
1998
47
Different secretion profiles of atrial and brain natriuretic peptides after acute volume loading in patients with ischemic heart disease. (9217917)
1997
48
Apolipoprotein A-I and B levels and the risk of ischemic heart disease during a five-year follow-up of men in the QuAcbec cardiovascular study. (8759066)
1996
49
Sex hormones and DHEA-SO4 in relation to ischemic heart disease mortality in diabetic subjects. The Wisconsin Epidemiologic Study of Diabetic Retinopathy. (8886548)
1996
50
The relationship of the restriction fragment length polymorphism of the apo-B gene to the blood lipid spectrum in patients with ischemic heart disease]. (7900201)
1994

Variations for Ischemic Heart Disease

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Expression for genes affiliated with Ischemic Heart Disease

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Expression patterns in normal tissues for genes affiliated with Ischemic Heart Disease

Search GEO for disease gene expression data for Ischemic Heart Disease.

Pathways for genes affiliated with Ischemic Heart Disease

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Compounds for genes affiliated with Ischemic Heart Disease

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Compounds related to Ischemic Heart Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 115)
idCompoundScoreTop Affiliating Genes
1polyethylene glycol 60004410.1APOA1, APOB
2maxepa4410.1APOA1, APOB
3lynestrenol449.9APOB, APOA1
4colestipol449.9APOA1, APOB
5levonorgestrel44 61 28 1112.9APOB, APOA1, F7
6tibolone449.8CRP, APOB, APOA1
7ezetimibe44 1110.8CRP, APOB, APOA1
8retinyl palmitate44 2410.8APOA1, APOB, APOA4
9intralipid449.8APOA1, APOB, APOA4
10rosuvastatin44 50 28 1112.7APOA1, APOB, CRP
11cerivastatin50 44 28 1112.7APOA1, CRP, APOB
12cholesterol ester449.7APOA1, APOB, APOA4
13bezafibrate44 28 1111.6APOA1, APOB, CRP
14mspi449.6APOB, APOA4, APOA1
15hydrochlorothiazide44 28 50 24 1113.5CRP, ACE, APOA1
16fenofibrate44 50 1111.4APOA1, APOB, CRP
17fosinopril44 1110.4ACE, NPPB, CRP
18celiprolol449.4ACE, NPPB
19ramipril44 1110.4ACE, CRP, NPPB
20valsartan44 61 28 1112.4CRP, ACE, NPPB
21telmisartan44 28 1111.4NPPB, ACE, CRP
22perindopril44 50 1111.4ACE, NPPB, CRP
23alacepril449.3ACE, NPPB
24pioglitazone28 44 50 1112.3NPPB, APOB, APOA1, CRP
25uric acid44 2410.3APOB, CRP, APOA1, NPPB
26kininogen449.3APOA1, APOB, ACE, F7
27sildenafil28 44 50 24 1113.3ACE, KCNJ5, NPPB
28homocysteine44 2410.3NPPB, APOB, APOA1, CRP
29enalapril44 50 1111.3NPPB, APOA1, ACE
30vitamin a44 24 1111.2APOA4, APOA1, CRP, APOB
31fluvastatin44 50 28 1112.2CRP, ACE, APOB, APOA1
32metformin44 50 1111.2CRP, ACE, APOB, APOA1
33candoxatril44 1110.2ACE, NPPB
34furosemide44 61 28 50 24 1114.2APOB, ACE, NPPB
35fibrinogen449.2APOA4, APOA1, APOB, CRP, F7
36nitroglycerin44 1110.1KCNJ5, ACE, NPPB, CRP
37captopril44 61 50 28 1113.1APOB, APOA1, ACE, NPPB
38atenolol44 50 28 24 1113.1APOA1, ACE, CRP, NPPB
39lactate449.0KCNJ5, APOA1, APOB, CRP, NPPB
40prostacyclin448.9APOA1, NPPB, CRP, ACE
41pravastatin44 50 28 24 1112.7ACE, NPPB, CRP, APOA1, APOB
42atorvastatin44 50 28 24 1112.7NPPB, ACE, APOB, APOA1, CRP
43aspirin44 50 28 2411.7APOB, ACE, CRP, NPPB, APOA1
44acetylcholine44 50 28 24 1112.7NPPB, ACE, APOA1, CRP, KCNJ5
45cholesterol44 28 24 1111.3ZNF202, APOA4, F7, APOA1, APOB, ACE
46testosterone44 61 24 1111.3KCNJ5, NPPB, CRP, APOB, APOA1
47creatinine448.1APOA1, APOA4, APOB, ACE, CRP, NPPB
48nitric oxide44 24 119.8NPPB, KCNJ5, CHI3L1, F7, ACE, GCLM
49glucose447.8KCNJ5, APOA4, APOB, F7, NPPB, CRP
50lipid447.5APOB, KCNJ5, APOA4, APOA1, ZNF202, CRP

GO Terms for genes affiliated with Ischemic Heart Disease

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Cellular components related to Ischemic Heart Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chylomicronGO:0426279.7APOA4, APOB
2high-density lipoprotein particleGO:0343649.7APOA1, APOA4
3endocytic vesicle lumenGO:0716829.7APOB, APOA1
4very-low-density lipoprotein particleGO:0343619.5APOB, APOA1, APOA4
5endoplasmic reticulum lumenGO:0057889.2F7, APOB, APOA1, APOA4
6early endosomeGO:0057699.1APOB, APOA1, APOA4
7extracellular regionGO:0055767.7APOA4, APOA1, APOB, ACE, CRP, NPPB
8extracellular spaceGO:0056157.0F7, APOA4, APOA1, APOB, CHI3L1, ACE

Biological processes related to Ischemic Heart Disease according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1lipoprotein biosynthetic processGO:04215810.0APOB, APOA1
2regulation of intestinal cholesterol absorptionGO:0303009.9APOA1, APOA4
3positive regulation of cholesterol esterificationGO:0108739.9APOA4, APOA1
4organ regenerationGO:0311009.8F7, APOA1
5phospholipid effluxGO:0337009.8APOA4, APOA1
6high-density lipoprotein particle remodelingGO:0343759.7APOA4, APOA1
7cholesterol transportGO:0303019.7APOA1, APOB
8cholesterol effluxGO:0333449.7APOB, APOA1, APOA4
9lipoprotein metabolic processGO:0421579.7APOA4, APOA1, APOB
10retinoid metabolic processGO:0015239.7APOB, APOA1, APOA4
11cholesterol homeostasisGO:0426329.6APOA4, APOA1, APOB
12cholesterol metabolic processGO:0082039.6APOB, APOA1, APOA4
13regulation of blood vessel sizeGO:0508809.6GCLM, NPPB
14phototransduction, visible lightGO:0076039.5APOB, APOA1, APOA4
15regulation of vasodilationGO:0423129.5ACE, NPPB
16reverse cholesterol transportGO:0436919.4APOA1, APOA4

Molecular functions related to Ischemic Heart Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cholesterol bindingGO:0154859.8CRP, APOA1
2phosphatidylcholine-sterol O-acyltransferase activator activityGO:0602289.4APOA1, APOA4
3cholesterol transporter activityGO:0171279.3APOB, APOA1, APOA4

Products for genes affiliated with Ischemic Heart Disease

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  • Antibodies
  • Proteins
  • Lysates

Sources for Ischemic Heart Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet