IHD
MCID: ISC006
MIFTS: 69

Ischemic Heart Disease (IHD) malady

Cardiovascular diseases category

Summaries for Ischemic Heart Disease

About this section
Sources:
8Disease Ontology, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Coronary artery disease (CAD) also known as atherosclerotic heart disease,coronary heart disease, or... more...

MalaCards: Ischemic Heart Disease, also known as myocardial ischemia, is related to stroke, ischemic and myocardial infarction. An important gene associated with Ischemic Heart Disease is F7 (coagulation factor VII (serum prothrombin conversion accelerator)), and among its related pathways are Selenium Pathway and Platelet activation, signaling and aggregation. The compounds lipid and cholesterol have been mentioned in the context of this disorder. Affiliated tissues include heart, bone and endothelial, and related mouse phenotypes are homeostasis/metabolism and cardiovascular system.

Disease Ontology:8 An extrinsic cardiomyopathy that is characterized by reduced blood supply to the cardiac muscles.

Aliases & Classifications for Ischemic Heart Disease

About this section
Sources:
60UMLS, 8Disease Ontology, 10DISEASES, 30LifeMap Discovery™, 44Novoseek, 38NCBI Bookshelf, 56SNOMED-CT, 34MeSH, 39NCIt, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

ischemic heart disease 8 10 30
myocardial ischemia 8 44 60
chronic myocardial ischaemia 8
coronary arteriosclerosis 60
ihd 38


Related Diseases for Ischemic Heart Disease

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Ischemic Heart Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 228)
idRelated DiseaseScoreTop Affiliating Genes
1stroke, ischemic31.0APOA1, APOB, CRP, F7, ACE
2myocardial infarction31.0KCNJ5, TNNI3, APOA1, APOB, NPPB, FABP12
3hypertension31.0APOA1, APOB, NPPB, LPL, CRP, ACE
4vascular disease30.9APOA1, APOB, LPL, CRP, F7, ACE
5coronary artery disease30.9KCNJ5, APOA1, APOB, NPPB, LPL, CRP
6atherosclerosis30.9APOA1, APOB, FABP12, LPXN, LPL, CRP
7diabetes mellitus30.9KCNJ5, APOA1, APOB, NPPB, LPL, CRP
8ischemia30.7PF4, NPPB, UCN, KCNJ5
9cerebrovascular disease30.6APOA1, APOB, LPL, ACE
10type 2 diabetes mellitus30.6KCNJ5, APOA1, APOB, FABP12, LPXN, LPL
11rheumatoid arthritis30.6PF4, CRP, LPL, APOA1, UCN
12arthritis30.6CRP
13obesity30.5KCNJ5, UCN, APOA1, APOB, FABP12, LPL
14arteriosclerosis30.5APOA1, APOB, LPL
15dilated cardiomyopathy30.4ACE, LPL, NPPB, TNNI3
16kawasaki disease30.4CRP, NPPB
17pneumonia30.4CRP
18acute myocardial infarction30.3KCNJ5, TNNI3, APOA1, APOB, NPPB, FABP12
19essential hypertension30.3APOA1, APOB, NPPB, LPXN, LPL, PF4
20peripheral vascular disease30.3APOA1, APOB, PF4, ACE
21coronary stenosis30.3APOA1, APOB
22hyperlipidemia type 330.3APOA1, APOB, LPL
23congestive heart failure30.3UCN, NPPB, ACE
24hyperuricemia30.3APOB
25diabetic retinopathy30.3ACE
26hyperhomocysteinemia30.1CRP
27coronary heart disease30.0TNNI3, ACE, F7, PF4, CRP, LPL
28amyloidosis30.0CRP, LPL, NPPB, APOA1
29familial hypercholesterolemia30.0APOA1, APOB, LPL
30hypothyroidism30.0APOB
31carotid stenosis30.0CRP
32aortic aneurysm30.0CRP
33osteoarthritis30.0CRP, UCN
34dementia30.0LPL
35peritonitis30.0CRP
36schizophrenia30.0IMPA1, FABP12
37coronary arteriosclerosis11.2
38hypertensive heart disease10.7
39ischemic bone disease10.6
40heart cancer10.5
41breast cancer10.5
42breast disease10.5
43aortic disease10.4
44brain disease10.4
45influenza10.4
46heart valve disease10.3
47coronary thrombosis10.3
48vaccinia10.3
49diabetic nephropathy10.3
50wegener's granulomatosis10.3

Graphical network of the top 20 diseases related to Ischemic Heart Disease:



Diseases related to ischemic heart disease

Clinical Features for Ischemic Heart Disease

About this section

Drugs & Therapeutics for Ischemic Heart Disease

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Ischemic Heart Disease

Drug clinical trials:

Search ClinicalTrials for Ischemic Heart Disease

Search NIH Clinical Center for Ischemic Heart Disease

Search CenterWatch for Ischemic Heart Disease

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Ischemic Heart Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Ischemic Heart Disease:
ACT34-CMI, bone marrow-derived cells for ischemic heart diseases
Adipocell
Adipose-derived mesenchymal stromal stem cells for ischemic heart disease
ADRCs, adipose-derived regenerative cells for treatment of cardiovascular disease
AMDC, autologous muscle-derived cells for ischemic heart failure
Autologous bone marrow-derived mesenchymal stem cells for treatment of heart muscle damage
Bone marrow-derived CD133+ stem cells for treatment of ischemic heart disease
Bone marrow-derived mesenchymal stem cells for treatment of heart diseases
Bone marrow-derived mesenchymal stem cells for treatment of ischemic heart disease
Bone marrow-derived mononuclear cells for ischemic cardiomyopathy
Bone marrow-derived mononucleated cells for heart disease
Bone marrow-derived stem cells for treatment of chronic ischemic heart failure
Bone marrow-derived stem cells for treatment of ischemic cardiomyopathy
Bone marrow-derived stem cells for treatment of severe chronic ischemic heart disease
Cardiac stem cells for treatment of ischemic cardiomyopathy
Cardiocell
CD34+ stem cells for treatment of congestive heart failure
Combination therapy of mononuclear cells with laser for coronary disease
Embryonic stem cell-derived cardiomyocytes for ischemic myocardium
Enriched bone marrow-derived progenitor cells for heart diseases
Mesendo, stem cell combination for treatment of cardiovascular diseases
Peripheral mononuclear cells CD34+ stem cells for treatment of myocardial ischemia
Peripheral or bone marrow-derived stem cells for chronic heart failure
StempeucelICM
Embryonic/Adult Cultured Cells Related to Ischemic Heart Disease:
Bone marrow-derived CD34+ stem cells (ACT34), PMIDs: 11283669, 12551872, 22163120, 20448213, 9020076, 17562958, 21737787
VEGF-A165-stimulated ADSCs
Adipose-derived stem and regenerative cell, PMIDs: 21082397, 22281257
Autologous muscle-derived cells
Bone marrow-derived mesenchymal stem cells (family)
Bone marrow-derived CD133+ cells
Bone marrow-derived mesenchymal stem cells , PMID: 22940024
Bone marrow-derived mesenchymal stem cells (family), PMIDs: 21052537, 19591227
Bone marrow-derived hematopoietic stem cells (family)
Bone marrow-derived stem cells
Bone marrow-derived mesenchymal stem cells , PMIDs: 21392602, 22940024
Bone marrow-derived mononuclear cells (family), PMIDs: 21392602, 22940024
Porcine bone marrow-derived mesenchymal stem cells, PMIDs: 21392602, 22940024
Human cardiac stem cells, PMIDs: 22088800, 22965994
Bone marrow-derived mesenchymal stem cells (family)
Bone marrow-derived hematopoietic stem cells (family), PMID: 22163120
Bone marrow-derived mononuclear cells (family)
Cardiomyocyte-like cells, PMID: 18941512
Bone marrow-derived progenitor cells, PMIDs: 23362308, 22936827, 18794392, 16990384, 16990385, 22651868
Bone marrow-derived mononuclear cells, PMIDs: 21323410, 20631864
Bone marrow-derived mesenchymal stem cells, PMIDs: 21323410, 20631864
Peripheral blood-derived hematopoietic stem cells (family)
Bone marrow-derived mononuclear cells, PMIDs: 20668107, 21596713, 19761394, 22834565
Bone marrow-derived mesenchymal stem cells (Stempeucel, PMID: 18720444

Genetic Tests for Ischemic Heart Disease

About this section

Anatomical Context for Ischemic Heart Disease

About this section
Sources:
30LifeMap Discovery™, 32MalaCards
See all sources

MalaCards organs/tissues related to Ischemic Heart Disease:

32
Heart, Bone, Endothelial, Bone marrow, Testes, Breast, Brain, Lung, Prostate, Eye, Spinal cord, Placenta

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Ischemic Heart Disease:
id TissueAnatomical CompartmentCell Relevance
1 LimbPelvic GirdleBone Marrow Stromal Cells Potential therapeutic candidate
2 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate

Animal Models for Ischemic Heart Disease or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Ischemic Heart Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537610.9APOA1, APOB, LPL, CRP, ZC3H12A, PF4
2MP:000538510.5ACE, KCNJ5, TNNI3, APOA1, APOB, NPPB

Publications for Ischemic Heart Disease

About this section
Sources:
50PubMed
See all sources

Articles related to Ischemic Heart Disease:

(show top 50)    (show all 840)
idTitleAuthorsYear
1
Elevated remnant cholesterol causes both low-grade inflammation and ischemic heart disease, whereas elevated low-density lipoprotein cholesterol causes ischemic heart disease without inflammation. (23926208)
2013
2
Angiogenesis inhibitor bevacizumab increases the risk of ischemic heart disease associated with chemotherapy: a meta-analysis. (23818962)
2013
3
Myocardial delivery of stromal cell-derived factor 1 in patients with ischemic heart disease: safe and promising. (23429606)
2013
4
Analgesic efficacy and outcome of transversus-abdominis plane block versus low thoracic-epidural analgesia after laparotomy in ischemic heart disease patients. (24375223)
2013
5
Total and high-molecular-weight adiponectin and risk of coronary heart disease and ischemic stroke in older adults. (23162097)
2013
6
Rationale, design and baseline characteristics of a study to evaluate effects of candesartan on cardiovascular events after drug-eluting stent implantation in patients with ischemic heart disease. (23411616)
2013
7
Door-to-door survey of cardiovascular health, stroke, and ischemic heart disease in rural coastal Ecuador - the Atahualpa Project: methodology and operational definitions. (23506643)
2013
8
Adherence to recommendations for fruit and vegetable intake, ethnicity and ischemic heart disease mortality. (23725771)
2013
9
The evaluation of perioperative safety of local anesthesia with lidocaine containing epinephrine in patients with ischemic heart disease. (24026990)
2013
10
Epidemiological and Pathogenic Relationship between Sleep Apnea and Ischemic Heart Disease. (23862060)
2013
11
Risk factors associated with ischemic heart disease occurence in acute ischemic stroke patients. (22660218)
2013
12
Cardiovascular magnetic resonance imaging in ischemic heart disease. (22696124)
2012
13
Initial strategy of revascularization versus optimal medical therapy for improving outcomes in ischemic heart disease: a review of the literature. (22555943)
2012
14
Alcohol consumption and ischemic heart disease mortality in Russia. (22508014)
2012
15
Regulatory systems for hypoxia-inducible gene expression in ischemic heart disease gene therapy. (21241757)
2011
16
Diagnosis of ischemic heart disease using CK-MB, troponin-I and ischemia modified albumin. (21456469)
2011
17
Gender differences in the treatment of ischemic heart disease. (21449886)
2011
18
The association of ghrelin polymorphisms with coronary artery disease and ischemic chronic heart failure in an elderly Chinese population. (21195705)
2011
19
Physical work demands, hypertension status, and risk of ischemic heart disease and all-cause mortality in the Copenhagen Male Study. (20852831)
2010
20
Prognostication of long-term outcomes for patients with ischemic heart disease. (21393989)
2010
21
Antihypertensive treatment, high triglycerides, and low high-density lipoprotein cholesterol and risk of ischemic heart disease mortality: a 16-year follow-up in the Copenhagen male study. (20156073)
2010
22
Lactoferrin is a novel predictor of fatal ischemic heart disease in diabetes mellitus type 2: long-term follow-up of the HUNT 1 study. (20598696)
2010
23
Lack of association of ischemic heart disease with COPD when taking into account classical cardiovascular risk factors. (21103405)
2010
24
Lipoprotein(a) and ischemic heart disease--a causal association? A review. (20106478)
2010
25
The utility of cardiopulmonary exercise testing to detect and track early-stage ischemic heart disease. (20884826)
2010
26
Ischemic heart disease and stroke in relation to blood DNA methylation. (20805753)
2010
27
The influence of six cardiovascular polymorphisms on a first event of ischemic heart disease is modified by sex and age. (19779330)
2009
28
Comparative assessment of antiinflammatory action of atorvastatin in ischemic heart disease and rheumatoid arthritis]. (18991814)
2008
29
Impact of nebivolol on levels of serum nitric oxide, plasma von Willebrand factor and exercise stress testing parameters in hypertensive and ischemic heart disease patients. (18651401)
2008
30
An application of the patient rule-induction method for evaluating the contribution of the Apolipoprotein E and Lipoprotein Lipase genes to predicting ischemic heart disease. (17436307)
2007
31
Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: The American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists. (17515473)
2007
32
Effects of soluble fiber (Plantago ovata husk) on plasma lipids, lipoproteins, and apolipoproteins in men with ischemic heart disease. (17413119)
2007
33
Spinal cord stimulation for ischemic heart disease and peripheral vascular disease. (17907475)
2007
34
Genetically determined high serum levels of mannose-binding lectin and agalactosyl IgG are associated with ischemic heart disease in rheumatoid arthritis. (17195187)
2007
35
Lipoprotein(a): an independent risk factor for ischemic heart disease that is dependent on triglycerides in subjects with type 2 diabetes mellitus. (17908332)
2007
36
CD40 ligand and risk of ischemic stroke or coronary events in patients with chronic coronary heart disease. (16503253)
2006
37
Primary prevention of ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council: cosponsored by the Atherosclerotic Peripheral Vascular Disease Interdisciplinary Working Group; Cardiovascular Nursing Council; Clinical Cardiology Council; Nutrition, Physical Activity, and Metabolism Council; and the Quality of Care and Outcomes Research Interdisciplinary Working Group. (16785347)
2006
38
Oxidized LDL and lipids as risk factors for ischemic heart disease in type 2 diabetes]. (16171015)
2005
39
Hypoxia-inducible factor 1alpha polymorphism and coronary collaterals in patients with ischemic heart disease. (16100168)
2005
40
Functional status and patient satisfaction: a comparison of ischemic heart disease, obstructive lung disease, and diabetes mellitus. (15963172)
2005
41
Effect of omega-3 polyunsaturated fatty acids of animal origin on changes in regulation of lipid peroxidation in patients with ischemic heart disease]. (15724620)
2004
42
Antioxidant action and therapeutic efficacy of laser irradiation of blood in patients with ischemic heart disease]. (12852010)
2003
43
Persistent elevation of C-reactive protein and ischemic heart disease in patients with continuous ambulatory peritoneal dialysis. (11840375)
2002
44
Clinical and experimental evidence of prostaglandin E1-induced angiogenesis in the myocardium of patients with ischemic heart disease. (12393092)
2002
45
Use of antioxidants and trimetazidine in preparation of patients with ischemic heart disease for coronary angiography]. (11234263)
2001
46
Urinary albumin excretion. An independent predictor of ischemic heart disease. (10446083)
1999
47
Hyperinsulinemia as an independent risk factor for ischemic heart disease. (8596596)
1996
48
Low serum TSH levels in patients with emergent conditions due to ischemic heart disease or congestive heart failure]. (7861644)
1994
49
Lipid peroxidation and hyperuricemia in patients with ischemic heart disease]. (2395265)
1990
50
Renal transplantation. Effect on the ischemic heart disease of essential malignant hypertension. (772241)
1976

Genetic Variations for Ischemic Heart Disease

About this section

Expression for genes affiliated with Ischemic Heart Disease

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Ischemic Heart Disease

Search GEO for disease gene expression data for Ischemic Heart Disease.

Pathways for genes affiliated with Ischemic Heart Disease

About this section
Sources:
37NCBI BioSystems Database, 53Reactome, 12EMD Millipore, 49PharmGKB
See all sources

Compounds for genes affiliated with Ischemic Heart Disease

About this section
Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience
See all sources

Compounds related to Ischemic Heart Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 111)
idCompoundScoreTop Affiliating Genes
1lipid4411.4KCNJ5, APOA1, APOB, NPPB, FABP12, LPXN
2cholesterol44 28 11 2414.3APOA1, APOB, FABP12, LPXN, LPL, CRP
3lactate4411.3KCNJ5, TNNI3, APOA1, APOB, NPPB, FABP12
4creatinine4411.3TNNI3, APOA1, APOB, NPPB, FABP12, CRP
5acetylcholine44 49 28 11 2415.2KCNJ5, UCN, APOA1, NPPB, LPL, CRP
6glucose4411.2PF4, KCNJ5, UCN, APOA1, NPPB, LPXN
7aspirin44 49 28 2414.1APOA1, APOB, NPPB, CRP, PF4, ACE
8metformin44 49 1113.1APOA1, APOB, LPL, CRP, ACE
9kininogen4411.1APOA1, APOB, PF4, F7, ACE
10pioglitazone44 49 28 1114.1APOA1, APOB, NPPB, LPL, CRP
11atorvastatin44 49 28 11 2415.1CRP, LPL, NPPB, APOB, APOA1
12carnitine4411.1APOA1, APOB, FABP12, LPL, CRP
13calcium44 49 11 2414.1KCNJ5, UCN, TNNI3, NPPB, FABP12, CRP
14atenolol44 28 49 11 2415.1ACE, CRP, NPPB, APOA1
15prostacyclin4411.1ACE, PF4, CRP, NPPB, APOA1
16nitroglycerin44 1112.1KCNJ5, NPPB, CRP, ACE
17bezafibrate44 28 1113.0CRP, LPL, APOB, APOA1
18fenofibrate44 49 1113.0APOA1, APOB, LPL, CRP
19vitamin a44 11 2413.0APOA1, APOB, FABP12, LPL, CRP
20dextran sulfate4411.0APOA1, APOB, LPL, PF4
21norepinephrine44 11 2413.0KCNJ5, UCN, LPL
22fluvastatin44 49 28 1114.0CRP, LPL, APOB, APOA1
23prostaglandin f2alpha4411.0UCN, FABP12, LPL, CRP
24fosinopril44 1112.0NPPB, CRP, ACE
25fenofibric acid44 2812.0APOA1, APOB, LPL
26triacylglycerol4411.0APOA1, APOB, FABP12, LPL
27pravastatin44 49 28 11 2415.0APOA1, APOB, NPPB, CRP
28ciprofibrate44 2812.0LPL, APOB, APOA1
29retinyl palmitate44 2412.0LPL, APOB, APOA1
30uric acid44 2411.9NPPB
31tirofiban44 1111.9NPPB, CRP, PF4
32ramipril44 1111.9NPPB, CRP, ACE
33intralipid4410.9APOA1, APOB, LPL
34indomethacin44 59 28 1113.9KCNJ5, APOA1, NPPB, LPL, PF4
35valsartan44 59 28 1113.9NPPB, CRP, ACE
36doxazosin44 1111.9APOA1, LPL, ACE
37warfarin44 49 11 2413.9PF4
38telmisartan44 28 1112.9NPPB, CRP, ACE
39perindopril44 49 1112.9NPPB, CRP, ACE
40tibolone4410.9CRP, APOB, APOA1
41adenylate4410.9KCNJ5, UCN, APOB, LPL, IMPA1, PF4
42cilostazol44 1111.8NPPB, PF4
43probucol44 1111.8APOA1, APOB, LPL
44alpha tocopherol4410.7LPL
45polyethylene glycol 60004410.7APOA1, APOB
46maxepa4410.6APOA1, APOB
47levonorgestrel44 59 28 1113.6F7, APOB, APOA1
48homocysteine44 2411.5APOA1, APOB, NPPB, CRP
49palmitate4410.5FABP12
50hydrochlorothiazide44 49 28 11 2414.3ACE, CRP, APOA1

GO Terms for genes affiliated with Ischemic Heart Disease

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Ischemic Heart Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.9PF4, IL27, F7, CRP, LPL, NPPB
2extracellular regionGO:00557610.8ACE, UCN, F7, PF4, CRP, LPL
3endocytic vesicle lumenGO:07168210.6APOB, APOA1
4very-low-density lipoprotein particleGO:03436110.5APOA1, APOB, LPL
5chylomicronGO:04262710.3LPL, APOB

Biological processes related to Ischemic Heart Disease according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of macrophage derived foam cell differentiationGO:01074410.8PF4, APOB, LPL
2lipoprotein metabolic processGO:04215710.8LPL, APOB, APOA1
3retinoid metabolic processGO:00152310.7LPL, APOA1, APOB
4lipoprotein biosynthetic processGO:04215810.7APOA1, APOB
5positive regulation of cholesterol storageGO:01088610.6APOB, LPL
6cholesterol transportGO:03030110.6APOA1, APOB
7positive regulation of lipid storageGO:01088410.6APOB, ZC3H12A
8regulation of vasodilationGO:04231210.5ACE, NPPB
9phototransduction, visible lightGO:00760310.3APOB, LPL, APOA1

Molecular functions related to Ischemic Heart Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cholesterol transporter activityGO:01712710.6APOB, APOA1
2receptor bindingGO:00510210.3IL27, F7, LPL, NPPB

Products for genes affiliated with Ischemic Heart Disease

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Ischemic Heart Disease

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet