MCID: ISC002
MIFTS: 57

Ischemic Optic Neuropathy malady

Eye diseases, Neuronal diseases categories

Summaries for Ischemic Optic Neuropathy

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63Wikipedia, 32MalaCards
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Wikipedia:63 Ischemic optic neuropathy (ION) is the loss of structure and function of a portion of the optic nerve... more...

MalaCards: Ischemic Optic Neuropathy, also known as optic neuropathy, ischemic, is related to retinal artery occlusion and retinal vein occlusion. An important gene associated with Ischemic Optic Neuropathy is GP1BA (glycoprotein Ib (platelet), alpha polypeptide), and among its related pathways are Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics and Formation of Fibrin Clot (Clotting Cascade). The compounds warfarin and tamoxifen have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and brain, and related mouse phenotypes are cardiovascular system and liver/biliary system.

Aliases & Classifications for Ischemic Optic Neuropathy

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Sources:
8Disease Ontology, 10DISEASES, 30LifeMap Discovery™, 60UMLS, 34MeSH, 27ICD9CM, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases, Neuronal diseases


Aliases & Descriptions:

ischemic optic neuropathy 8 10 30
optic neuropathy, ischemic 60


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Disease Ontology8 DOID:12010
MeSH34 D018917
SNOMED-CT56 14357004
ICD9CM27 377.41

Related Diseases for Ischemic Optic Neuropathy

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Ischemic Optic Neuropathy family:

Optic Neuropathy, Anterior Ischemic

Diseases related to Ischemic Optic Neuropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 261)
idRelated DiseaseScoreTop Affiliating Genes
1retinal artery occlusion31.0APOH
2retinal vein occlusion30.7VEGFA, MTHFR, F5, APOH
3cataract30.7G6PD
4hypertension30.6PDE5A, ACE, NOS3, F2, AGT, AGTR1
5hepatitis c30.6F2
6hepatitis30.6F2
7stroke, ischemic30.6F5, F2
8thrombophilia30.6F2, MTHFR, F5, APOH
9central retinal vein occlusion30.6VEGFA, MTHFR, F5, APOH
10migraine30.5MTHFR, APOH, PDE5A
11antiphospholipid syndrome30.5APOH, F5, MTHFR, F2
12branch retinal artery occlusion30.4F5
13polycythemia30.4ITGB3, G6PD
14polycythemia vera30.4G6PD, ITGB3
15peritonitis30.4F2, CRP
16vasculitis30.4F2, CRP, APOH
17diabetes mellitus30.3ACE, NOS3, GP1BA, VEGFA, AGT, AGTR1
18intracranial aneurysm30.2NOS3
19prostatitis30.2PDE5A
20hepatitis a30.2F2
21retinal vascular occlusion30.2APOH, F5
22pneumonia30.2CRP
23crohn's disease30.2CRP
24uveitis30.2ACE
25thrombocytosis30.2F2, GP1BA, CRP
26behcet's disease30.2F5, CRP, APOH
27thrombocytopenia30.2APOH, ITGB3, F5, GP1BA, F2
28deficiency anemia30.1ACE, F2, CRP, G6PD
29diabetic retinopathy30.1ITGB3, AGTR1, AGT, VEGFA, NOS3, ACE
30vascular disease30.1MTHFR, F5, ITGB3, CRP, G6PD, APOH
31ischemic neuropathy11.5
32neuropathy11.5
33retinitis10.9
34neuritis10.7
35optic neuritis10.7
36diabetic neuropathy10.6
37central retinal artery occlusion10.6
38glaucoma10.6
39choroiditis10.5
40optic neuropathy, anterior ischemic10.4
41axonal neuropathy10.4
42cerebritis10.4
43herpes zoster10.4
44burns10.3
45cavernous sinus thrombosis10.3
46wegener's granulomatosis10.3
47polyarteritis nodosa10.3
48macular retinal edema10.3
49papilledema10.3
50refractive error10.3

Graphical network of the top 20 diseases related to Ischemic Optic Neuropathy:



Diseases related to ischemic optic neuropathy

Clinical Features for Ischemic Optic Neuropathy

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Drugs & Therapeutics for Ischemic Optic Neuropathy

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™
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Approved drugs:

Search CenterWatch for Ischemic Optic Neuropathy

Drug clinical trials:

Search ClinicalTrials for Ischemic Optic Neuropathy

Search NIH Clinical Center for Ischemic Optic Neuropathy

Search CenterWatch for Ischemic Optic Neuropathy

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Ischemic Optic Neuropathy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Ischemic Optic Neuropathy:
Renexus
Embryonic/Adult Cultured Cells Related to Ischemic Optic Neuropathy:
Human retinal stem cells secreting CNTF, PMIDs: 16805711, 17508034, 16505355, 23049090, 15684670, 12581701, 15223826, 18830926

Genetic Tests for Ischemic Optic Neuropathy

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Anatomical Context for Ischemic Optic Neuropathy

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32MalaCards
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MalaCards organs/tissues related to Ischemic Optic Neuropathy:

32
Eye, Endothelial, Brain, Spinal cord, Heart, Liver, Breast, Prostate, Testes

Animal Models for Ischemic Optic Neuropathy or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Ischemic Optic Neuropathy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.3ACE, NOS3, F2, AGT, AGTR1, ITGB3
2MP:00053707.9CCNDBP1, ITGB3, F5, AGT, VEGFA, NOS3
3MP:00107687.7ACE, G6PD, ITGB3, NOS3, MTHFR, AGTR1
4MP:00053787.6ACE, ITGB3, F5, MTHFR, AGTR1, AGT
5MP:00053766.7BEX1, G6PD, CRP, ITGB3, F5, NOS3

Publications for Ischemic Optic Neuropathy

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50PubMed
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Articles related to Ischemic Optic Neuropathy:

(show top 50)    (show all 527)
idTitleAuthorsYear
1
Anterior ischemic optic neuropathy and dialysis: Effect of hypotension. (23772133)
2013
2
Visual Loss due to non-arteritic anterior ischemic optic neuropathy (NAION) immediately following routine strabismus surgery under general anesthesia-a case report. (22906382)
2012
3
Ischemic optic neuropathy and cataract extraction: What do I need to know? (23436973)
2012
4
Risk factors associated with ischemic optic neuropathy after spinal fusion surgery. (22185873)
2012
5
Diffusion-weighted MRI in acute posterior ischemic optic neuropathy. (23162251)
2012
6
Acute posterior ischemic optic neuropathy mimicking posterior cerebral artery stroke visualized by 3-tesla MRI. (23185170)
2012
7
Bilateral simultaneous nonarteritic anterior ischemic optic neuropathy after ingestion of sildenafil for erectile dysfunction. (22481954)
2012
8
Bilateral posterior ischemic optic neuropathy in a patient with severe diabetic ketoacidosis. (21475607)
2011
9
Neuroprotective effect of hyperbaric oxygen therapy on anterior ischemic optic neuropathy. (21577253)
2011
10
Case of ischemic optic neuropathy developed eleven days after an aortic arch replacement. (22167492)
2011
11
A case of nonarteritic anterior ischemic optic neuropathy of a male with family history of the disease after receiving sildenafil. (22034568)
2011
12
Early diabetes mellitus or hypertension is not significantly associated with severity of vision loss in nonarteritic anterior ischemic optic neuropathy. (21825204)
2011
13
Ischemic optic neuropathy. (20695733)
2010
14
Anterior ischemic optic neuropathy in a case of Takayasu's arteritis. (21217905)
2010
15
Arteritic anterior ischemic optic neuropathy with positive myeloperoxidase antineutrophil cytoplasmic antibody. (20700804)
2010
16
Clinical profile of patients with nonarteritic anterior ischemic optic neuropathy presented to a referral center from 2003 to 2008. (19722769)
2009
17
Translation of clinical studies to clinical practice: survey on the treatment of nonarteritic anterior ischemic optic neuropathy. (19878760)
2009
18
Pathogenesis of nonarteritic anterior ischemic optic neuropathy. (19667362)
2009
19
Anterior ischemic optic neuropathy after unilateral radical neck dissection: case report and review. (17981414)
2008
20
Anterior ischemic optic neuropathy associated with metabolic syndrome. (18408840)
2008
21
Optic disc evaluation by optical coherence tomography in nonarteritic anterior ischemic optic neuropathy. (17724191)
2007
22
Anterior ischemic optic neuropathy. (18054657)
2007
23
Wegener's granulomatosis and posterior ischemic optic neuropathy: Atypical associated conditions. (17574109)
2007
24
Amiodarone and ischemic optic neuropathy. (17414882)
2007
25
Correlations between retinal nerve fiber layer and visual field in eyes with nonarteritic anterior ischemic optic neuropathy. (17157797)
2007
26
Ischemic optic neuropathy. (17577864)
2007
27
Case report: association of combined nonarteritic anterior ischemic optic neuropathy (NAION) and obstruction of cilioretinal artery with overdose of Viagra. (16117695)
2005
28
Anterior ischemic optic neuropathy in an extreme dipper dialysis patient. (16191062)
2005
29
Ischemic optic neuropathy and carotid dissection. (15753417)
2005
30
Posner-Schlossman syndrome and nonarteritic anterior ischemic optic neuropathy. (14663306)
2003
31
Posterior ischemic optic neuropathy following endoscopic sinus surgery. (14574305)
2003
32
Functional and cellular responses in a novel rodent model of anterior ischemic optic neuropathy. (14507856)
2003
33
Optic disc structure and shock-induced anterior ischemic optic neuropathy. (12578776)
2003
34
Chlamydia in anterior ischemic optic neuropathy. (12065860)
2002
35
Central retinal vein occlusion and nonarteritic ischemic optic neuropathy in 2 patients with mild iron deficiency anemia. (11244344)
2001
36
Bilateral non-arteritic anterior ischemic optic neuropathy in a patient with autoimmune thrombocytopenia. (10887933)
2000
37
Delayed anterior ischemic optic neuropathy after neck dissection. (10680875)
2000
38
Prothrombotic and vascular risk factors in nonarteritic anterior ischemic optic neuropathy. (10599644)
1999
39
Hypotensive ischemic optic neuropathy and peritoneal dialysis. (10482108)
1999
40
Bilateral anterior ischemic optic neuropathy following influenza vaccination. (9532544)
1998
41
Aspirin therapy in nonarteritic anterior ischemic optic neuropathy. (9186127)
1997
42
Application of HELP in nonarteritic anterior ischemic optic neuropathy: a prospective, randomized, controlled study. (9034837)
1997
43
Anterior ischemic optic neuropathy and activated protein C resistance. A case report and review of the literature. (9304527)
1997
44
Hyperbaric oxygen therapy for nonarteritic anterior ischemic optic neuropathy. (8862051)
1996
45
Apoptosis of retinal ganglion cells in anterior ischemic optic neuropathy. (8602791)
1996
46
Ischemic optic neuropathy. (8592243)
1996
47
Postoperative ischemic optic neuropathy. (7726399)
1995
48
Ischemic optic neuropathy after sumatriptan in a migraine with aura patient. (8014044)
1994
49
Systemic diseases associated with nonarteritic anterior ischemic optic neuropathy. (7977604)
1994
50
Anterior ischemic optic neuropathy associated with macrocytic anemia. (2150841)
1990

Genetic Variations for Ischemic Optic Neuropathy

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Expression for genes affiliated with Ischemic Optic Neuropathy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ischemic Optic Neuropathy

Search GEO for disease gene expression data for Ischemic Optic Neuropathy.

Pathways for genes affiliated with Ischemic Optic Neuropathy

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Sources:
49PharmGKB, 37NCBI BioSystems Database, 53Reactome, 52R&D Systems, 12EMD Millipore, 51QIAGEN
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Compounds for genes affiliated with Ischemic Optic Neuropathy

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Ischemic Optic Neuropathy according to GeneCards/GeneDecks:

(show top 50)    (show all 154)
idCompoundScoreTop Affiliating Genes
1warfarin44 49 11 2413.7APOH
2tamoxifen44 49 28 1113.5G6PD
3uric acid44 2411.3F5, G6PD, APOH
4estrogen4410.2APOH, PDE5A
5kaolin4410.0F2, F5, APOH
6phosphatidylserine44 28 1112.0F2, APOH, ITGB3, GP1BA
7ristocetin4410.0ITGB3, F5, GP1BA, F2
8aliskiren44 1110.9ACE, AGTR1, AGT
9glucose449.8APOH, AGTR1, AGT, GP1BA
10benazepril44 1110.8ACE, MTHFR, AGT, AGTR1
11sele449.8AGT, ACE, MTHFR, ITGB3
12abciximab44 1110.8F2, GP1BA, ITGB3, CRP
13saralasin449.7AGT, AGTR1, ACE
14kininogen449.7APOH, GP1BA, F2, ACE, F5
15vitamin b12449.7MTHFR, F5, CRP, APOH, G6PD
16diltiazem44 28 1111.7ACE, F2, AGTR1, AGT
178-isoprostane449.7NOS3, AGTR1, CRP, APOH
18amlodipine44 49 11 2412.7ACE, AGTR1, AGT, NOS3
19heparin44 28 11 2412.6VEGFA, AGT, MTHFR, APOH, GP1BA
20atenolol44 28 49 11 2413.6AGTR1, CRP, ACE, AGT
21lisinopril44 11 2411.6VEGFA, AGTR1, AGT, ACE
22valsartan44 59 28 1112.6AGTR1, AGT, ACE, CRP
23telmisartan44 28 1111.6ACE, AGT, CRP, AGTR1
24eprosartan44 28 1111.6AGT, ACE, AGTR1
25acetylcholine44 49 28 11 2413.6ACE, AGT, AGTR1
26carvedilol44 49 28 1112.6AGTR1, VEGFA, NOS3, ACE
27hydrochlorothiazide44 49 28 11 2413.6CRP, AGT, AGTR1, ACE
28clopidogrel49 44 11 2412.5CRP, ITGB3, F2, NOS3, ACE
29cyclophosphamide44 49 1111.5MTHFR, F5, CRP, G6PD, NOS3, APOH
30azathioprine44 49 2 1112.4G6PD, APOH, NOS3, CRP, MTHFR, AGTR1
31candesartan44 28 1111.4ACE, NOS3, VEGFA, AGT, AGTR1
32ang ii449.4ACE, AGTR1, NOS3, VEGFA, AGT
33serine449.4GP1BA, AGT, AGTR1, MT-ND1, G6PD
34epinephrine44 11 2411.4GP1BA, AGTR1, AGT, F2, G6PD, F5
35atorvastatin44 49 28 11 2413.3CRP, F5, NOS3, AGT, VEGFA
36nitroglycerin44 1110.3CRP, NOS3, ACE, AGTR1, PDE5A
37homocysteine44 2410.2CRP, NOS3, F2, MTHFR, F5, APOH
38citrate449.2NOS3, F2, F5, G6PD, CRP
39lactate449.2F5, MT-ND1, G6PD, CRP, APOH, F2
40folate449.1F5, NOS3, CRP, G6PD, APOH, MTHFR
41perindopril44 49 1111.1AGT, ACE, AGTR1, NOS3, CRP, VEGFA
42adenine44 11 2411.0F5, AGTR1, AGT, GP1BA, MTHFR
43n acetylcysteine449.0CRP, AGTR1, AGT, VEGFA, G6PD, F2
44simvastatin44 49 59 28 11 2414.0F2, NOS3, CRP, F5, AGTR1, AGT
45fibrinogen448.7F2, F5, CRP, APOH, MTHFR, AGTR1
46creatinine448.6F2, F5, AGTR1, CRP, AGT, ACE
47alanine448.6GP1BA, AGTR1, MTHFR, MT-ND1, CRP, F5
48aspirin44 49 28 2411.3G6PD, AGTR1, MTHFR, F5, ITGB3, CRP
49vegf448.2AGTR1, NOS3, AGT, CRP, PDE5A, APOH
50prostacyclin448.1VEGFA, PDE5A, APOH, CRP, F5, AGTR1

GO Terms for genes affiliated with Ischemic Optic Neuropathy

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16Gene Ontology
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Cellular components related to Ischemic Optic Neuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.5ACE, F2, VEGFA, AGT, F5, CRP

Biological processes related to Ischemic Optic Neuropathy according to GeneCards/GeneDecks:

(show all 29)
idNameGO IDScoreTop Affiliating Genes
1regulation of blood coagulationGO:03019310.4GP1BA, F2
2negative regulation of fibrinolysisGO:05191810.3APOH, F2
3negative regulation of platelet activationGO:01054410.3NOS3, F2
4blood coagulation, intrinsic pathwayGO:00759710.3APOH, GP1BA, F2
5positive regulation of NAD(P)H oxidase activityGO:03386410.2AGTR1, AGT
6regulation of blood vessel size by renin-angiotensinGO:00203410.2AGT, AGTR1
7regulation of renal sodium excretionGO:03581310.2AGTR1, AGT
8renin-angiotensin regulation of aldosterone productionGO:00201810.2AGTR1, AGT
9regulation of renal output by angiotensinGO:00201910.2AGT, ACE
10regulation of systemic arterial blood pressure by renin-angiotensinGO:00308110.2ACE, AGTR1
11positive regulation of cholesterol esterificationGO:01087310.2AGTR1, AGT
12negative regulation of lipid storageGO:01088810.1CRP, ITGB3
13positive regulation of blood coagulationGO:03019410.1APOH, F2
14positive regulation of reactive oxygen species metabolic processGO:200037910.0F2, AGT, AGTR1
15regulation of vasodilationGO:04231210.0AGTR1, ACE
16low-density lipoprotein particle remodelingGO:03437410.0AGTR1, AGT
17blood vessel remodelingGO:00197410.0ACE, NOS3, AGT
18regulation of vasoconstrictionGO:0192299.9AGTR1, AGT, ACE
19positive regulation of cardiac muscle hypertrophyGO:0106139.9PDE5A, AGT
20positive regulation of endothelial cell migrationGO:0105959.9ITGB3, AGT, VEGFA
21negative regulation of macrophage derived foam cell differentiationGO:0107459.9ITGB3, CRP
22platelet degranulationGO:0025769.8VEGFA, F5, ITGB3
23positive regulation of cellular protein metabolic processGO:0322709.8AGTR1, AGT
24positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.8ITGB3, AGT, VEGFA
25platelet activationGO:0301689.6ITGB3, F5, VEGFA, GP1BA, F2
26positive regulation of protein phosphorylationGO:0019349.6F2, VEGFA, ITGB3
27kidney developmentGO:0018229.6AGTR1, AGT, VEGFA, ACE
28angiotensin maturationGO:0020039.6AGT, ACE
29blood coagulationGO:0075968.9NOS3, F2, GP1BA, VEGFA, F5, ITGB3

Molecular functions related to Ischemic Optic Neuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1bradykinin receptor bindingGO:0317119.9AGTR1, ACE
2acetyltransferase activator activityGO:0106989.8AGTR1, AGT
3vascular endothelial growth factor receptor 2 bindingGO:0431849.5ITGB3, VEGFA
4protein bindingGO:0055156.5CCNDBP1, APOH, G6PD, CRP, ITGB3, F5

Products for genes affiliated with Ischemic Optic Neuropathy

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Ischemic Optic Neuropathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet