MCID: ISC002
MIFTS: 52

Ischemic Optic Neuropathy malady

Eye, Neuronal categories

Summaries for Ischemic Optic Neuropathy

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Ischemic optic neuropathy (ION) is the loss of structure and function of a portion of the optic nerve... more...

MalaCards: Ischemic Optic Neuropathy, also known as optic neuropathy, ischemic, is related to hepatitis a and hepatitis c. An important gene associated with Ischemic Optic Neuropathy is GP1BA (glycoprotein Ib (platelet), alpha polypeptide), and among its related pathways are Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics and Formation of Fibrin Clot (Clotting Cascade). The compounds warfarin and tamoxifen have been mentioned in the context of this disorder. Affiliated tissues include liver, spinal cord and brain, and related mouse phenotypes are cardiovascular system and liver/biliary system.

Aliases & Classifications for Ischemic Optic Neuropathy

Sources:
8Disease Ontology, 10DISEASES, 31LifeMap Discovery™, 61UMLS, 35MeSH, 27ICD9CM, 57SNOMED-CT
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye, Neuronal


Aliases & Descriptions:

ischemic optic neuropathy 8 10 31
optic neuropathy, ischemic 61


External Ids:

Disease Ontology8 DOID:12010
MeSH35 D018917
SNOMED-CT57 14357004
ICD9CM27 377.41

Related Diseases for Ischemic Optic Neuropathy

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Ischemic Optic Neuropathy family:

optic neuropathy, anterior ischemic

Diseases related to Ischemic Optic Neuropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 246)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis a30.7F2
2hepatitis c30.7F2
3stroke, ischemic30.6F5, F2
4thrombophilia30.6F2, MTHFR, F5, APOH
5central retinal vein occlusion30.6VEGFA, MTHFR, F5, APOH
6antiphospholipid syndrome30.6APOH, F5, MTHFR, F2
7hepatitis b30.4F2
8branch retinal artery occlusion30.4F5
9polycythemia vera30.4G6PD, ITGB3
10blindness30.4VEGFA
11vasculitis30.4F2, CRP, APOH
12intracranial aneurysm30.2NOS3
13uveitis30.2ACE
14thrombocytosis30.2F2, GP1BA, CRP
15thrombocytopenia30.2APOH, ITGB3, F5, GP1BA, F2
16deficiency anemia30.2ACE, F2, CRP, G6PD
17vascular disease30.1MTHFR, F5, ITGB3, CRP, G6PD, APOH
18ischemic neuropathy11.5
19optic neuropathy, anterior ischemic11.4
20nonarteritic anterior ischemic optic neuropathy11.2
21n syndrome10.8
22central retinal artery occlusion10.6
23sleep apnea10.5
24herpes zoster10.4
25herpes zoster ophthalmicus10.4
26axonal neuropathy10.3
27cavernous sinus thrombosis10.3
28polyarteritis nodosa10.3
29strabismus10.3
30posner-schlossman syndrome10.3
31ischemic retinopathy10.2
32moyamoya disease10.2
33estrogen excess10.2
34substernal goiter10.2
35foster-kennedy syndrome10.2
36pseudoxanthoma elasticum10.2
37myoma10.2
38diabetic ketoacidosis10.2
39uremic neuropathy10.2
40optic disk drusen10.2
41cystoid macular edema10.2
42angioid streaks10.2
43vogt-koyanagi-harada disease10.2
44empty sella syndrome10.2
45carotid artery dissection10.2
46diabetic macular edema10.2
47hereditary spherocytosis10.2
48ocular hypertension10.2
49iron deficiency anemia10.2
50femoral neuropathy10.2

Graphical network of the top 20 diseases related to Ischemic Optic Neuropathy:



Diseases related to ischemic optic neuropathy

Clinical Features for Ischemic Optic Neuropathy

Drugs & Therapeutics for Ischemic Optic Neuropathy

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™
See all sources

Approved drugs:

Search CenterWatch for Ischemic Optic Neuropathy

Drug clinical trials:

Search ClinicalTrials for Ischemic Optic Neuropathy

Search NIH Clinical Center for Ischemic Optic Neuropathy

Search CenterWatch for Ischemic Optic Neuropathy

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Ischemic Optic Neuropathy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Ischemic Optic Neuropathy:
Renexus
Embryonic/Adult Cultured Cells Related to Ischemic Optic Neuropathy:
Human retinal stem cells secreting CNTF, PMIDs: 16805711, 17508034, 16505355, 23049090, 15684670, 12581701, 15223826, 18830926

Genetic Tests for Ischemic Optic Neuropathy

Anatomical Context for Ischemic Optic Neuropathy

Sources:
33MalaCards
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MalaCards organs/tissues related to Ischemic Optic Neuropathy:

33
Liver, Spinal cord, Brain, Heart, Breast, Prostate, B cells, Endothelial

Animal Models for Ischemic Optic Neuropathy or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Ischemic Optic Neuropathy:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.3G6PD, CRP, ITGB3, AGTR1, AGT, F2
2MP:00053707.9CCNDBP1, ITGB3, F5, AGT, VEGFA, NOS3
3MP:00107687.7MTHFR, F5, ITGB3, G6PD, AGTR1, AGT
4MP:00053787.6G6PD, ITGB3, F5, MTHFR, AGTR1, AGT
5MP:00053766.7BEX1, APOH, G6PD, CRP, ITGB3, F5

Publications for Ischemic Optic Neuropathy

Sources:
51PubMed
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Articles related to Ischemic Optic Neuropathy:

(show top 50)    (show all 527)
idTitleAuthorsYear
1
Neuroprotective effects of recombinant human granulocyte colony-stimulating factor (G-CSF) in a rat model of anterior ischemic optic neuropathy (rAION). (24316388)
2014
2
A Study of Prevalence and Risk Factors of Diabetic Retinopathy in Patients with Non-Arteritic Anterior Ischemic Optic Neuropathy (NA-AION). (24171808)
2013
3
Treatment of non-arteritic anterior ischemic optic neuropathy with high-dose systemic corticosteroids. (22644095)
2013
4
RhoA activity and post-ischemic inflammation in an experimental model of adult rodent anterior ischemic optic neuropathy. (23973747)
2013
5
Bilateral non-arteritic anterior ischemic optic neuropathy following second-trimester spontaneous abortion-related haemorrhage. (22898194)
2012
6
Nonarteritic anterior ischemic optic neuropathy in a child with optic disk drusen. (22525184)
2012
7
Shape analysis of the peripapillary RPE layer in papilledema and ischemic optic neuropathy. (21896851)
2011
8
Interferon alfa-associated anterior ischemic optic neuropathy. (20630599)
2011
9
Comparison of the correlations between optic disc rim area and retinal nerve fiber layer thickness in glaucoma and nonarteritic anterior ischemic optic neuropathy. (21168811)
2011
10
Optic disk excavation in nonarteritic anterior ischemic optic neuropathy. (20436358)
2011
11
Postoperative ischemic optic neuropathy. (20407342)
2010
12
Arteritic anterior ischemic optic neuropathy treated with intravenous prostaglandin E(1) and steroids. (22477619)
2010
13
Ischemic optic neuropathy associated with low-dose interferon alfa: report of two cases. (19194130)
2009
14
Perioperative ischemic optic neuropathy: a case control analysis of 126,666 surgical procedures at a single institution. (19194151)
2009
15
Anterior ischemic optic neuropathy due to giant cell arteritis with normal inflammatory markers. (18386041)
2008
16
Progressive damage along the optic nerve following induction of crush injury or rodent anterior ischemic optic neuropathy in transgenic mice. (19052651)
2008
17
Dilated superior ophthalmic veins and posterior ischemic optic neuropathy after prolonged spine surgery. (19145135)
2008
18
Optic disc and peripapillary morphology in unilateral nonarteritic anterior ischemic optic neuropathy and age- and refraction-matched normals. (18342941)
2008
19
Nonarteritic anterior ischemic optic neuropathy: natural history of visual outcome. (17698200)
2008
20
Treatment of erectile dysfunction by phosphodiesterase-5 inhibitors and nonarteritic anterior ischemic optic neuropathy (NOIAN)]. (17969789)
2007
21
The ischemic optic neuropathy decompression trial. (17998521)
2007
22
A case of Adamantiades-BehAset disease with ischemic optic neuritis (posterior optic neuropathy). (17976143)
2007
23
Nonarteritic ischemic optic neuropathy. (17339146)
2007
24
Efficacy and tolerability of 0.2% brimonidine tartrate for the treatment of acute non-arteritic anterior ischemic optic neuropathy (NAION): a 3-month, double-masked, randomised, placebo-controlled trial. (16151785)
2006
25
Bilateral ischemic optic neuropathy after transurethral prostatic resection: a case report. (17034630)
2006
26
Perioperative posterior ischemic optic neuropathy: review of the literature. (15621075)
2005
27
Nonarteritic anterior ischemic optic neuropathy. (16264343)
2005
28
Aggressive glioma of adulthood simulating ischemic optic neuropathy. (15883294)
2005
29
Bilateral anterior ischemic optic neuropathy after liposuction. (15348986)
2004
30
Acute ischemic optic neuropathy associated with an abdominal compartment syndrome in a burn patient. (15225919)
2004
31
LDL-apheresis in acute anterior ischemic optic neuropathy. (15163068)
2004
32
Ischemic optic neuropathy after endoscopic sinus surgery: a case report. (12720006)
2003
33
Posterior ischemic optic neuropathy related to profound shock after penetrating thoracoabdominal trauma. (12356108)
2002
34
Anterior ischemic optic neuropathy associated with idiopathic aldosteronism and hypertension. (11901293)
2002
35
Anterior ischemic optic neuropathy after a trans-Atlantic airplane journey. (11931805)
2002
36
Mistaken treatment of anterior ischemic optic neuropathy with interferon beta-1a. (12112066)
2002
37
Chlamydia pneumoniae seropositivity and the risk of nonarteritic ischemic optic neuropathy. (11927434)
2002
38
Anterior ischemic optic neuropathy in children: case reports and review of the literature. (12057795)
2002
39
The role of angiotensin converting enzyme and angiotensin II type 1 receptor gene polymorphisms in patients with nonarteritic anterior ischemic optic neuropathy. (10964835)
2000
40
Axonal loss in a patient with anterior ischemic optic neuropathy as measured with scanning laser polarimetry. (11124316)
2000
41
Sildenafil (Viagra) associated anterior ischemic optic neuropathy. (10676804)
2000
42
Crowded optic discs and AION. Anterior ischemic optic neuropathy. (10599650)
1999
43
Incidence of nonarteritic anterior ischemic optic neuropathy. (9186104)
1997
44
Nonarteritic anterior ischemic optic neuropathy: role of nocturnal arterial hypotension. (9230848)
1997
45
Comparison of visual function in fellow eyes after bilateral nonarteritic anterior ischemic optic neuropathy. (9022112)
1997
46
Spontaneous recovery of progressive anterior ischemic optic neuropathy. (11548787)
1996-1997
47
Pain in anterior ischemic optic neuropathy. (7780575)
1995
48
Non-arteritic anterior ischemic optic neuropathy and refraction. (8936778)
1995
49
Optic neuritis and ischemic neuropathy. What we thought we already knew. (1841571)
1991
50
Ischemic optic neuropathy in cavernous sinus thrombosis. (629684)
1978

Genetic Variations for Ischemic Optic Neuropathy

Expression for genes affiliated with Ischemic Optic Neuropathy

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Ischemic Optic Neuropathy

Search GEO for disease gene expression data for Ischemic Optic Neuropathy.

Pathways for genes affiliated with Ischemic Optic Neuropathy

Sources:
50PharmGKB, 38NCBI BioSystems Database, 54Reactome, 53R&D Systems, 12EMD Millipore, 52QIAGEN
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Compounds for genes affiliated with Ischemic Optic Neuropathy

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Ischemic Optic Neuropathy according to GeneCards/GeneDecks:

(show top 50)    (show all 154)
idCompoundScoreTop Affiliating Genes
1warfarin45 50 11 2413.7APOH
2tamoxifen45 50 29 1113.5G6PD
3uric acid45 2411.3F5, G6PD, APOH
4estrogen4510.2APOH, PDE5A
5kaolin4510.0F2, F5, APOH
6phosphatidylserine45 29 1112.0F2, APOH, ITGB3, GP1BA
7ristocetin4510.0ITGB3, F5, GP1BA, F2
8aliskiren45 1110.9ACE, AGTR1, AGT
9glucose459.8APOH, AGTR1, AGT, GP1BA
10benazepril45 1110.8ACE, MTHFR, AGT, AGTR1
11sele459.8AGT, ACE, MTHFR, ITGB3
12abciximab45 1110.8F2, GP1BA, ITGB3, CRP
13saralasin459.7AGT, AGTR1, ACE
14kininogen459.7APOH, GP1BA, F2, ACE, F5
15vitamin b12459.7MTHFR, F5, CRP, APOH, G6PD
16diltiazem45 29 1111.7ACE, F2, AGTR1, AGT
178-isoprostane459.7NOS3, AGTR1, CRP, APOH
18amlodipine45 50 11 2412.7ACE, AGTR1, AGT, NOS3
19heparin45 29 11 2412.6VEGFA, AGT, MTHFR, APOH, GP1BA
20atenolol45 29 50 11 2413.6AGTR1, CRP, ACE, AGT
21lisinopril45 11 2411.6VEGFA, AGTR1, AGT, ACE
22valsartan45 60 29 1112.6AGTR1, AGT, ACE, CRP
23telmisartan45 29 1111.6ACE, AGT, CRP, AGTR1
24eprosartan45 29 1111.6AGT, ACE, AGTR1
25acetylcholine45 50 29 11 2413.6ACE, AGT, AGTR1
26carvedilol45 50 29 1112.6AGTR1, VEGFA, NOS3, ACE
27hydrochlorothiazide45 50 29 11 2413.6CRP, AGT, AGTR1, ACE
28clopidogrel50 45 11 2412.5CRP, ITGB3, F2, NOS3, ACE
29cyclophosphamide45 50 1111.5MTHFR, F5, CRP, G6PD, NOS3, APOH
30azathioprine45 50 2 1112.4G6PD, APOH, NOS3, CRP, MTHFR, AGTR1
31candesartan45 29 1111.4ACE, NOS3, VEGFA, AGT, AGTR1
32ang ii459.4ACE, AGTR1, NOS3, VEGFA, AGT
33serine459.4GP1BA, AGT, AGTR1, MT-ND1, G6PD
34epinephrine45 11 2411.4GP1BA, AGTR1, AGT, F2, G6PD, F5
35atorvastatin45 50 29 11 2413.3CRP, F5, NOS3, AGT, VEGFA
36nitroglycerin45 1110.3CRP, NOS3, ACE, AGTR1, PDE5A
37homocysteine45 2410.2CRP, NOS3, F2, MTHFR, F5, APOH
38citrate459.2NOS3, F2, F5, G6PD, CRP
39lactate459.2F5, MT-ND1, G6PD, CRP, APOH, F2
40folate459.1F5, NOS3, CRP, G6PD, APOH, MTHFR
41perindopril45 50 1111.1AGT, ACE, AGTR1, NOS3, CRP, VEGFA
42adenine45 11 2411.0F5, AGTR1, AGT, GP1BA, MTHFR
43n acetylcysteine459.0CRP, AGTR1, AGT, VEGFA, G6PD, F2
44simvastatin45 50 60 29 11 2414.0F2, NOS3, CRP, F5, AGTR1, AGT
45fibrinogen458.7F2, F5, CRP, APOH, MTHFR, AGTR1
46creatinine458.6F2, F5, AGTR1, CRP, AGT, ACE
47alanine458.6GP1BA, AGTR1, MTHFR, MT-ND1, CRP, F5
48aspirin45 50 29 2411.3G6PD, AGTR1, MTHFR, F5, ITGB3, CRP
49vegf458.2AGTR1, NOS3, AGT, CRP, PDE5A, APOH
50prostacyclin458.1VEGFA, PDE5A, APOH, CRP, F5, AGTR1

GO Terms for genes affiliated with Ischemic Optic Neuropathy

Sources:
16Gene Ontology
See all sources

Cellular components related to Ischemic Optic Neuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.5ACE, F2, VEGFA, AGT, F5, CRP

Biological processes related to Ischemic Optic Neuropathy according to GeneCards/GeneDecks:

(show all 29)
idNameGO IDScoreTop Affiliating Genes
1regulation of blood coagulationGO:03019310.4GP1BA, F2
2negative regulation of fibrinolysisGO:05191810.3APOH, F2
3negative regulation of platelet activationGO:01054410.3NOS3, F2
4blood coagulation, intrinsic pathwayGO:00759710.3APOH, GP1BA, F2
5positive regulation of NAD(P)H oxidase activityGO:03386410.2AGTR1, AGT
6regulation of blood vessel size by renin-angiotensinGO:00203410.2AGT, AGTR1
7regulation of renal sodium excretionGO:03581310.2AGTR1, AGT
8renin-angiotensin regulation of aldosterone productionGO:00201810.2AGTR1, AGT
9regulation of renal output by angiotensinGO:00201910.2AGT, ACE
10regulation of systemic arterial blood pressure by renin-angiotensinGO:00308110.2ACE, AGTR1
11positive regulation of cholesterol esterificationGO:01087310.2AGTR1, AGT
12negative regulation of lipid storageGO:01088810.1CRP, ITGB3
13positive regulation of blood coagulationGO:03019410.1APOH, F2
14positive regulation of reactive oxygen species metabolic processGO:200037910.0F2, AGT, AGTR1
15regulation of vasodilationGO:04231210.0AGTR1, ACE
16low-density lipoprotein particle remodelingGO:03437410.0AGTR1, AGT
17blood vessel remodelingGO:00197410.0ACE, NOS3, AGT
18regulation of vasoconstrictionGO:0192299.9AGTR1, AGT, ACE
19positive regulation of cardiac muscle hypertrophyGO:0106139.9PDE5A, AGT
20positive regulation of endothelial cell migrationGO:0105959.9ITGB3, AGT, VEGFA
21negative regulation of macrophage derived foam cell differentiationGO:0107459.9ITGB3, CRP
22platelet degranulationGO:0025769.8VEGFA, F5, ITGB3
23positive regulation of cellular protein metabolic processGO:0322709.8AGTR1, AGT
24positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.8ITGB3, AGT, VEGFA
25platelet activationGO:0301689.6ITGB3, F5, VEGFA, GP1BA, F2
26positive regulation of protein phosphorylationGO:0019349.6F2, VEGFA, ITGB3
27kidney developmentGO:0018229.6AGTR1, AGT, VEGFA, ACE
28angiotensin maturationGO:0020039.6AGT, ACE
29blood coagulationGO:0075968.9NOS3, F2, GP1BA, VEGFA, F5, ITGB3

Molecular functions related to Ischemic Optic Neuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1acetyltransferase activator activityGO:0106989.9AGT, AGTR1
2bradykinin receptor bindingGO:0317119.8ACE, AGTR1
3vascular endothelial growth factor receptor 2 bindingGO:0431849.5VEGFA, ITGB3
4protein bindingGO:0055156.5F5, ITGB3, CRP, G6PD, APOH, AGTR1

Products for genes affiliated with Ischemic Optic Neuropathy

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Ischemic Optic Neuropathy

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet