MCID: ISC002
MIFTS: 49

Ischemic Optic Neuropathy malady

Eye diseases, Neuronal diseases categories

Aliases & Classifications for Ischemic Optic Neuropathy

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Aliases & Descriptions for Ischemic Optic Neuropathy:

Name: Ischemic Optic Neuropathy 30 10
 
Optic Neuropathy, Ischemic 61


Classifications:



Summaries for Ischemic Optic Neuropathy

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Wikipedia:64 Ischemic optic neuropathy (ION) is the loss of structure and function of a portion of the optic nerve... more...

MalaCards based summary: Ischemic Optic Neuropathy, also known as optic neuropathy, ischemic, is related to nonarteritic anterior ischemic optic neuropathy and retinal artery occlusion. An important gene associated with Ischemic Optic Neuropathy is GP1BA (glycoprotein Ib (platelet), alpha polypeptide), and among its related pathways are Formation of Fibrin Clot (Clotting Cascade) and Angiogenesis. The compounds benazepril and chymostatin have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and liver, and related mouse phenotypes are liver/biliary system and embryogenesis.

Related Diseases for Ischemic Optic Neuropathy

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Diseases related to Ischemic Optic Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 209)
idRelated DiseaseScoreTop Affiliating Genes
1nonarteritic anterior ischemic optic neuropathy32.5PDE5A, MTHFR, F5
2retinal artery occlusion31.9APOH
3branch retinal artery occlusion31.3F5
4migraine31.2MTHFR, APOH, PDE5A
5thrombophilia31.1F2, APOH, MTHFR, F5
6retinal vein occlusion31.1F5, VEGFA, APOH, MTHFR
7antiphospholipid syndrome31.0MTHFR, F2, F5, APOH
8retinal vascular occlusion31.0APOH, F5
9central retinal vein occlusion30.9F5, VEGFA, APOH, MTHFR
10hellp syndrome30.8MTHFR, APOH, F5
11vascular disease30.8VEGFA, APOH
12diabetic macular edema30.7VEGFA
13vasculitis30.6F2, APOH, CRP
14behcet's disease30.5APOH, F5, CRP
15thrombocytosis30.4F2, CRP, GP1BA
16liver disease30.4F5, CRP, F2
17thrombocytopenia30.3F5, ITGB3, GP1BA, F2, APOH
18deficiency anemia30.2ACE, F2, G6PD, CRP
19neuropathy11.5
20arteritic anterior ischemic optic neuropathy11.0
21retinitis10.9
22neuritis10.7
23optic neuritis10.7
24choroiditis10.6
25thrombophlebitis10.6APOH
26priapism10.6PDE5A
27sneddon syndrome10.6APOH
28central retinal artery occlusion10.6
29eclampsia10.6MTHFR
30factor xiii deficiency10.6F5
31acute chest syndrome10.6NOS3
32glucosephosphate dehydrogenase deficiency10.5G6PD
33pyruvate kinase deficiency10.5G6PD
34factor viii deficiency10.5F5
35mediterranean spotted fever10.5G6PD
36riboflavin deficiency10.5MTHFR
37orthostatic intolerance10.5AGTR1
38cataract10.5
39sleep apnea10.5
40endotheliitis10.5
41gitelman syndrome10.5AGT
42factor xii deficiency10.5APOH, F5
43homocysteinemia10.5MTHFR, F5
44mondor disease10.5F5, APOH
45hepatitis a10.5F2
46hepatitis10.5
47hepatitis c10.5
48peritonitis10.5
49transient cerebral ischemia10.5APOH, MTHFR
50placental abruption10.5MTHFR, F5

Graphical network of the top 20 diseases related to Ischemic Optic Neuropathy:



Diseases related to ischemic optic neuropathy

Symptoms for Ischemic Optic Neuropathy

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Drugs & Therapeutics for Ischemic Optic Neuropathy

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Drug clinical trials:

Search ClinicalTrials for Ischemic Optic Neuropathy

Search NIH Clinical Center for Ischemic Optic Neuropathy

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Ischemic Optic Neuropathy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Ischemic Optic Neuropathy:
Renexus
Embryonic/Adult Cultured Cells Related to Ischemic Optic Neuropathy:
Human retinal stem cells secreting CNTF, PMIDs: 16805711, 17508034, 16505355, 23049090, 15684670, 12581701, 15223826, 18830926

Genetic Tests for Ischemic Optic Neuropathy

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Anatomical Context for Ischemic Optic Neuropathy

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MalaCards organs/tissues related to Ischemic Optic Neuropathy:

31
Eye, Endothelial, Liver, Brain, Spinal cord, Heart, Breast, Prostate, Testes, B cells

Animal Models for Ischemic Optic Neuropathy or affiliated genes

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MGI Mouse Phenotypes related to Ischemic Optic Neuropathy:

35 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.6NOS3, F5, ITGB3, ACE, AGT, VEGFA
2MP:00053808.5F2, EDN1, VEGFA, G6PD, F5, ITGB3
3MP:00053678.3AGT, AGTR1, NOS3, ITGB3, ACE, EDN1
4MP:00053898.3NOS3, F2, ITGB3, ACE, MTHFR, VEGFA
5MP:00053698.2VEGFA, AGT, NOS3, ITGB3, BEX1, EDN1
6MP:00053908.2ITGB3, MTHFR, VEGFA, EDN1, F2, NOS3
7MP:00036318.1F2, EDN1, VEGFA, MTHFR, G6PD, F5
8MP:00053877.8F2, VEGFA, ACE, ITGB3, NOS3, AGT
9MP:00053787.7F5, VEGFA, AGTR1, F2, AGT, NOS3
10MP:00107687.2EDN1, AGT, ITGB3, F2, F5, NOS3
11MP:00053857.2AGT, AGTR1, F5, ITGB3, CRP, ACE
12MP:00053766.1GP1BA, ITGB3, EDN1, AGTR1, AGT, NOS3

Publications for Ischemic Optic Neuropathy

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Articles related to Ischemic Optic Neuropathy:

(show top 50)    (show all 556)
idTitleAuthorsYear
1
Choroidal thickness in non-arteritic anterior ischemic optic neuropathy. (25488646)
2015
2
Combined anterior ischemic optic neuropathy and hemiretinal artery occlusion during hemodialysis. (25677295)
2015
3
Anterior ischemic optic neuropathy in pediatric peritoneal dialysis: risk factors and therapy. (24488506)
2014
4
Readout-Segmented Diffusion-Weighted Imaging in a Critical Anatomic Area - Diagnosing Posterior Ischemic Optic Neuropathy (PION). (25329511)
2014
5
Efficacy of granulocyte-colony stimulating factor treatment in a rat model of anterior ischemic optic neuropathy. (25317164)
2014
6
Sequential episodes of perioperative ischemic optic neuropathy after hip surgery. (24621863)
2014
7
Severe, early axonal degeneration following experimental anterior ischemic optic neuropathy. (25249599)
2014
8
Intravitreal bevacizumab for the treatment of nonarteritic anterior ischemic optic neuropathy: a prospective trial. (23370417)
2013
9
Sectoral loss of myelin and axons in anterior ischemic optic neuropathy. (23528450)
2013
10
Anterior ischemic optic neuropathy and dialysis: Effect of hypotension. (23772133)
2013
11
Tonic pupil, anterior ischemic optic neuropathy in a teenager with Takayasu arteritis. (24314433)
2013
12
Sustained neuroprotection from a single intravitreal injection of PGJ2 in a rodent model of anterior ischemic optic neuropathy. (24106118)
2013
13
A Study of Prevalence and Risk Factors of Diabetic Retinopathy in Patients with Non-Arteritic Anterior Ischemic Optic Neuropathy (NA-AION). (24171808)
2013
14
Evaluation of inner retinal thickness around the optic disc using optical coherence tomography of a rodent model of nonarteritic ischemic optic neuropathy. (23053634)
2013
15
Impending anterior ischemic optic neuropathy with elements of retinal vein occlusion in a patient on interferon for polycythemia vera. (23152654)
2012
16
You're the flight surgeon: nonarteritic ischemic optic neuropathy. (22764620)
2012
17
Bilateral posterior ischemic optic neuropathy in a patient with severe diabetic ketoacidosis. (21475607)
2011
18
Cellular inflammation in nonarteritic anterior ischemic optic neuropathy and its primate model. (22159678)
2011
19
Ischemic optic neuropathy as a rare but potentially devastating complication of liposuction. (21460684)
2011
20
Changes in cholinergic amacrine cells after rodent anterior ischemic optic neuropathy (rAION). (20847114)
2011
21
Non-arteritic ischemic optic neuropathy followed by intravitreal bevacizumab injection: is there an association? (20534939)
2010
22
A case of decreased visual field after uneventful cataract surgery: nonarteritic anterior ischemic optic neuropathy. (20157417)
2010
23
Clinical profile of patients with nonarteritic anterior ischemic optic neuropathy presented to a referral center from 2003 to 2008. (19722769)
2009
24
Non-arteritic anterior ischemic optic neuropathy and thrombophilia. (18958485)
2009
25
Nonarteritic anterior ischemic optic neuropathy associated with chronic anemia: a case series of myelodysplastic syndrome patients. (19668557)
2009
26
Ischemic optic neuropathy associated with low-dose interferon alfa: report of two cases. (19194130)
2009
27
Visual function in anterior ischemic optic neuropathy: effect of Vision Restoration Therapy--a pilot study. (18207164)
2008
28
Ischemic optic neuropathy. (18826805)
2008
29
A primate model of nonarteritic anterior ischemic optic neuropathy. (18326695)
2008
30
Nonarteritic anterior ischemic optic neuropathy after uneventful phacoemulsification: case report. (17768569)
2007
31
A case of polyarteritis nodosa complicated by left central retinal artery occlusion, ischemic optic neuropathy, and retinal vasculitis. (16575492)
2007
32
Incidence of nonarteritic anterior ischemic optic neuropathy in adult Chinese: the Beijing Eye Study. (17534837)
2007
33
Perioperative posterior ischemic optic neuropathy: review of the literature. (15621075)
2005
34
Bilateral anterior ischemic optic neuropathy after liposuction. (15348986)
2004
35
Anterior ischemic optic neuropathy following off-pump cardiac bypass surgery. (15513001)
2003
36
Recurrent facial palsy occurring with metastatic thymic carcinoid and nonarteritic ischemic optic neuropathy. (12644770)
2003
37
Overlap of optic neuritis and anterior ischemic optic neuropathy. (12601716)
2003
38
Posterior ischemic optic neuropathy related to profound shock after penetrating thoracoabdominal trauma. (12356108)
2002
39
Chlamydia in anterior ischemic optic neuropathy. (12065860)
2002
40
Comparative studies on pattern VECP between patients with ischemic optic neuropathy and optic neuritis. (10990041)
2000
41
Ophthaproblem. Anterior ischemic optic neuropathy. (10424264)
1999
42
Prothrombotic and vascular risk factors in nonarteritic anterior ischemic optic neuropathy. (10599644)
1999
43
Incidence of nonarteritic anterior ischemic optic neuropathy. (9186104)
1997
44
Bilateral nonarteritic anterior ischemic optic neuropathy. (9022091)
1997
45
Anterior ischemic optic neuropathy following neck dissection. (9059874)
1997
46
Anterior ischemic optic neuropathy associated with pulseless disease. (8751345)
1995
47
Postoperative ischemic optic neuropathy. (7726399)
1995
48
Fluorescein angiography in acute nonarteritic anterior ischemic optic neuropathy. (8116751)
1994
49
Risk factors in nonarteritic anterior ischemic optic neuropathy. (2077825)
1990
50
Ischemic optic neuropathy in chronic papilledema. (7362508)
1980

Variations for Ischemic Optic Neuropathy

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Expression for genes affiliated with Ischemic Optic Neuropathy

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Search GEO for disease gene expression data for Ischemic Optic Neuropathy.

Pathways for genes affiliated with Ischemic Optic Neuropathy

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Pathways related to Ischemic Optic Neuropathy according to GeneCards Suite gene sharing:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8GP1BA, F5, F2
2
Show member pathways
Angiogenesis36
9.7NOS3, VEGFA
3
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway59
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB59
Development Angiopoietin Tie2 signaling59
9.7F2, AGTR1, NOS3
4
Show member pathways
9.6ITGB3, GP1BA, F2
5
Show member pathways
thioredoxin pathway36
9.5F2, MTHFR, CRP
6
Show member pathways
9.4EDN1, AGT, AGTR1, F2
7
Show member pathways
9.4ACE, AGT, F2, AGTR1
8
Show member pathways
9.4AGT, AGTR1, NOS3, ACE
99.4EDN1, VEGFA, NOS3
109.4NOS3, PDE5A
11
Show member pathways
9.3F5, VEGFA, ITGB3
12
Show member pathways
9.3ITGB3, VEGFA, NOS3
13
Show member pathways
9.3VEGFA, NOS3, ITGB3
14
Show member pathways
VEGFR1 specific signals36
9.3NOS3, ITGB3, VEGFA
15
Show member pathways
9.2VEGFA, EDN1, CRP
16
Show member pathways
Development EDNRB signaling59
Development ACM2 and ACM4 activation of ERK59
Cell adhesion Integrin inside out signaling59
Development G Proteins mediated regulation MARK ERK signaling59
Signal transduction IP3 signaling59
Development Angiotensin signaling via PYK259
Development EPO induced MAPK pathway59
9.0ITGB3, NOS3, AGTR1, F2, EDN1
17
Show member pathways
7.8F2, VEGFA, ITGB3, PDE5A, F5, NOS3

Compounds for genes affiliated with Ischemic Optic Neuropathy

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Compounds related to Ischemic Optic Neuropathy according to GeneCards Suite gene sharing:

(show top 50)    (show all 218)
idCompoundScoreTop Affiliating Genes
1benazepril44 50 1111.8ACE, AGTR1, AGT, MTHFR
2chymostatin449.7EDN1, ACE, AGTR1, AGT
3ristocetin449.6GP1BA, F5, F2, ITGB3
4sele449.6AGT, MTHFR, ITGB3, ACE
5kininogen449.6F2, APOH, ACE, F5, GP1BA
6warfarin44 50 24 1112.6MTHFR, ACE, F5, APOH, F2
7irbesartan44 28 50 1112.5AGTR1, AGT, ACE, EDN1
8diltiazem44 28 50 1112.5EDN1, ACE, AGTR1, AGT, F2
9quinapril44 50 1111.5CRP, ACE, EDN1, AGTR1
10lisinopril44 50 24 1112.5VEGFA, ACE, AGTR1, AGT
11vitamin b12449.5APOH, CRP, G6PD, F5, MTHFR
12telmisartan44 28 1111.4AGTR1, CRP, AGT, ACE
138-isoprostane449.4EDN1, APOH, NOS3, CRP, AGTR1
14valsartan44 60 28 1112.3AGT, CRP, AGTR1, EDN1, ACE
15atenolol44 50 28 24 1113.3AGT, AGTR1, EDN1, ACE, CRP
16uric acid44 2410.3APOH, F5, AGTR1, CRP, MTHFR, G6PD
17candesartan44 50 28 1112.3AGT, NOS3, ACE, VEGFA, AGTR1
18phosphatidylserine44 28 1111.2F2, GP1BA, G6PD, ITGB3, F5, APOH
19azathioprine44 1 50 1112.2CRP, G6PD, APOH, MTHFR, NOS3, AGTR1
20carvedilol44 50 28 1112.2NOS3, AGTR1, ACE, VEGFA, EDN1
21epinephrine44 24 1111.2F5, G6PD, GP1BA, F2, EDN1, AGTR1
22losartan44 50 28 1112.2EDN1, ACE, CRP, AGT, AGTR1
23clopidogrel44 50 24 1112.1NOS3, CRP, F2, ACE, ITGB3
24abciximab44 1110.0ITGB3, GP1BA, CRP, F2
25pravastatin44 50 28 24 1113.0MTHFR, ACE, CRP, AGTR1, NOS3
26homocysteine44 2410.0MTHFR, CRP, APOH, F5, NOS3, AGT
27ang ii449.0EDN1, VEGFA, NOS3, AGTR1, AGT, ACE
28hydrochlorothiazide44 28 50 24 1112.9AGT, AGTR1, ACE, CRP
29perindopril44 50 1110.8NOS3, CRP, ACE, VEGFA, AGT, AGTR1
30cyclophosphamide44 50 1110.8F5, NOS3, CRP, APOH, MTHFR, G6PD
31lactate448.7CRP, F5, MT-ND1, APOH, G6PD, F2
32heparin44 28 24 1111.7APOH, F2, AGT, GP1BA, MTHFR, VEGFA
33simvastatin44 50 60 28 24 1113.7VEGFA, F2, AGTR1, F5, NOS3, AGT
34sildenafil28 44 50 24 1112.6PDE5A, ACE, EDN1, VEGFA, NOS3
35atorvastatin44 50 28 24 1112.6F5, CRP, AGT, NOS3, EDN1, VEGFA
36n acetylcysteine448.5F2, CRP, AGTR1, AGT, G6PD, VEGFA
37nitroglycerin44 119.5EDN1, ACE, NOS3, PDE5A, CRP, AGTR1
38folate448.5F5, CRP, PDE5A, NOS3, MTHFR, G6PD
39fibrinogen448.5MTHFR, APOH, GP1BA, AGTR1, ITGB3, CRP
40creatinine448.2APOH, F2, EDN1, G6PD, MTHFR, AGTR1
41acetylcholine44 50 28 24 1112.1AGTR1, AGT, PDE5A, CRP, NOS3, ACE
42glucose448.1GP1BA, AGTR1, APOH, G6PD, AGT, MT-ND1
43alanine448.1F5, F2, GP1BA, MTHFR, MT-ND1, AGTR1
44serine448.0G6PD, F2, AGT, NOS3, F5, ITGB3
45nitric oxide44 24 119.9F5, AGTR1, AGT, EDN1, ACE, PDE5A
46aspirin44 50 28 2410.9ACE, F2, ITGB3, CRP, F5, NOS3
47estrogen447.5ITGB3, MTHFR, G6PD, AGTR1, NOS3, F5
48vegf447.2ITGB3, APOH, EDN1, F5, PDE5A, NOS3
49prostacyclin447.1AGTR1, GP1BA, VEGFA, APOH, ACE, PDE5A
50calcium44 50 24 119.8CRP, EDN1, ITGB3, GP1BA, FLVCR2, ACE

GO Terms for genes affiliated with Ischemic Optic Neuropathy

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Cellular components related to Ischemic Optic Neuropathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.2EDN1, VEGFA, ACE, CRP, F5, AGT
2extracellular spaceGO:00056157.7AGT, F2, EDN1, VEGFA, APOH, ACE

Biological processes related to Ischemic Optic Neuropathy according to GeneCards Suite gene sharing:

(show all 43)
idNameGO IDScoreTop Affiliating Genes
1regulation of blood vessel size by renin-angiotensinGO:000203410.4AGTR1, AGT
2positive regulation of NAD(P)H oxidase activityGO:003386410.4AGTR1, AGT
3regulation of renal sodium excretionGO:003581310.4AGT, AGTR1
4renin-angiotensin regulation of aldosterone productionGO:000201810.4AGTR1, AGT
5regulation of blood coagulationGO:003019310.4F2, GP1BA
6negative regulation of smooth muscle cell apoptotic processGO:003439210.3APOH, EDN1
7positive regulation of cholesterol esterificationGO:001087310.3AGTR1, AGT
8negative regulation of fibrinolysisGO:005191810.3APOH, F2
9regulation of renal output by angiotensinGO:000201910.3ACE, AGT
10regulation of systemic arterial blood pressure by renin-angiotensinGO:000308110.3ACE, AGTR1
11low-density lipoprotein particle remodelingGO:003437410.3AGTR1, AGT
12artery smooth muscle contractionGO:001482410.3EDN1, AGT
13positive regulation of blood coagulationGO:003019410.3APOH, F2
14regulation of systemic arterial blood pressure by endothelinGO:000310010.3NOS3, EDN1
15blood coagulation, intrinsic pathwayGO:000759710.2GP1BA, APOH, F2
16negative regulation of platelet activationGO:001054410.2NOS3, F2
17positive regulation of cellular protein metabolic processGO:003227010.2AGT, AGTR1
18regulation of vasodilationGO:004231210.2ACE, AGTR1
19angiotensin maturationGO:000200310.2ACE, AGT
20negative regulation of blood coagulationGO:003019510.2APOH, EDN1
21positive regulation of reactive oxygen species metabolic processGO:0200037910.1AGTR1, F2, AGT
22positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling paGO:005148210.1EDN1, AGTR1
23positive regulation of macrophage derived foam cell differentiationGO:001074410.1AGT, AGTR1
24positive regulation of renal sodium excretionGO:003581510.1EDN1, AGT
25blood vessel remodelingGO:000197410.0NOS3, AGT, ACE
26negative regulation of lipid storageGO:001088810.0ITGB3, CRP
27nitric oxide mediated signal transductionGO:000726310.0AGT, NOS3
28fibrinolysisGO:00427309.9GP1BA, F2
29negative regulation of macrophage derived foam cell differentiationGO:00107459.8ITGB3, CRP
30regulation of vasoconstrictionGO:00192299.8ACE, EDN1, AGT, AGTR1
31cell surface receptor signaling pathwayGO:00071669.7EDN1, F2, GP1BA
32positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.7VEGFA, ITGB3, AGT
33platelet degranulationGO:00025769.7F5, VEGFA, ITGB3
34positive regulation of vascular endothelial growth factor receptor signaling pathwayGO:00309499.6VEGFA, ITGB3
35positive regulation of protein phosphorylationGO:00019349.6F2, VEGFA, ITGB3
36kidney developmentGO:00018229.6VEGFA, ACE, AGT, AGTR1
37positive regulation of cardiac muscle hypertrophyGO:00106139.5AGT, PDE5A, EDN1
38positive regulation of endothelial cell migrationGO:00105959.4EDN1, VEGFA, ITGB3, AGT
39positive regulation of branching involved in ureteric bud morphogenesisGO:00901909.4AGT, VEGFA
40response to hypoxiaGO:00016669.4CRP, EDN1, MTHFR, VEGFA
41platelet activationGO:00301689.3ITGB3, VEGFA, F5, F2, GP1BA
42positive regulation of MAP kinase activityGO:00434069.2VEGFA, EDN1, PDE5A
43blood coagulationGO:00075968.2NOS3, F5, VEGFA, GP1BA, PDE5A, ITGB3

Molecular functions related to Ischemic Optic Neuropathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1bradykinin receptor bindingGO:003171110.0AGTR1, ACE
2NADP bindingGO:00506619.7G6PD, MTHFR, NOS3
3vascular endothelial growth factor receptor 2 bindingGO:00431849.4ITGB3, VEGFA
4growth factor activityGO:00080839.4AGT, VEGFA, F2
5platelet-derived growth factor receptor bindingGO:00051619.2ITGB3, VEGFA
6protein bindingGO:00055156.7AGTR1, F2, EDN1, GP1BA, VEGFA, APOH

Sources for Ischemic Optic Neuropathy

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet