MCID: ISC002
MIFTS: 49

Ischemic Optic Neuropathy malady

Eye diseases, Neuronal diseases categories

Aliases & Classifications for Ischemic Optic Neuropathy

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Ischemic Optic Neuropathy, Aliases & Descriptions:

Name: Ischemic Optic Neuropathy 30 11
 
Optic Neuropathy, Ischemic 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases, Neuronal diseases


Summaries for Ischemic Optic Neuropathy

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Wikipedia:63 Ischemic optic neuropathy (ION) is the loss of structure and function of a portion of the optic nerve... more...

MalaCards based summary: Ischemic Optic Neuropathy, also known as optic neuropathy, ischemic, is related to nonarteritic anterior ischemic optic neuropathy and retinal artery occlusion. An important gene associated with Ischemic Optic Neuropathy is GP1BA (glycoprotein Ib (platelet), alpha polypeptide), and among its related pathways are Formation of Fibrin Clot (Clotting Cascade) and Angiogenesis. The compounds benazepril and chymostatin have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and liver, and related mouse phenotypes are liver/biliary system and embryogenesis.

Related Diseases for Ischemic Optic Neuropathy

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Diseases related to Ischemic Optic Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 209)
idRelated DiseaseScoreTop Affiliating Genes
1nonarteritic anterior ischemic optic neuropathy32.5PDE5A, MTHFR, F5
2retinal artery occlusion31.9APOH
3branch retinal artery occlusion31.3F5
4migraine31.2MTHFR, APOH, PDE5A
5thrombophilia31.1F2, APOH, MTHFR, F5
6retinal vein occlusion31.1F5, VEGFA, APOH, MTHFR
7antiphospholipid syndrome31.0MTHFR, F2, F5, APOH
8retinal vascular occlusion31.0APOH, F5
9central retinal vein occlusion30.9F5, VEGFA, APOH, MTHFR
10hellp syndrome30.8MTHFR, APOH, F5
11vascular disease30.8VEGFA, APOH
12diabetic macular edema30.7VEGFA
13vasculitis30.6F2, APOH, CRP
14behcet's disease30.5APOH, F5, CRP
15thrombocytosis30.4F2, CRP, GP1BA
16liver disease30.4F5, CRP, F2
17thrombocytopenia30.3F5, ITGB3, GP1BA, F2, APOH
18deficiency anemia30.2ACE, F2, G6PD, CRP
19neuropathy11.5
20arteritic anterior ischemic optic neuropathy11.0
21retinitis10.9
22neuritis10.7
23optic neuritis10.7
24choroiditis10.6
25thrombophlebitis10.6APOH
26priapism10.6PDE5A
27sneddon syndrome10.6APOH
28central retinal artery occlusion10.6
29eclampsia10.6MTHFR
30factor xiii deficiency10.6F5
31acute chest syndrome10.6NOS3
32glucosephosphate dehydrogenase deficiency10.5G6PD
33pyruvate kinase deficiency10.5G6PD
34factor viii deficiency10.5F5
35mediterranean spotted fever10.5G6PD
36riboflavin deficiency10.5MTHFR
37orthostatic intolerance10.5AGTR1
38cataract10.5
39sleep apnea10.5
40endotheliitis10.5
41gitelman syndrome10.5AGT
42factor xii deficiency10.5APOH, F5
43homocysteinemia10.5MTHFR, F5
44mondor disease10.5F5, APOH
45hepatitis a10.5F2
46hepatitis10.5
47hepatitis c10.5
48peritonitis10.5
49transient cerebral ischemia10.5APOH, MTHFR
50placental abruption10.5MTHFR, F5

Graphical network of the top 20 diseases related to Ischemic Optic Neuropathy:



Diseases related to ischemic optic neuropathy

Symptoms for Ischemic Optic Neuropathy

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Drugs & Therapeutics for Ischemic Optic Neuropathy

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Drug clinical trials:

Search ClinicalTrials for Ischemic Optic Neuropathy

Search NIH Clinical Center for Ischemic Optic Neuropathy

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Ischemic Optic Neuropathy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Ischemic Optic Neuropathy:
Renexus
Embryonic/Adult Cultured Cells Related to Ischemic Optic Neuropathy:
Human retinal stem cells secreting CNTF, PMIDs: 16805711, 17508034, 16505355, 23049090, 15684670, 12581701, 15223826, 18830926

Genetic Tests for Ischemic Optic Neuropathy

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Anatomical Context for Ischemic Optic Neuropathy

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MalaCards organs/tissues related to Ischemic Optic Neuropathy:

31
Eye, Endothelial, Liver, Brain, Spinal cord, Heart, Breast, Prostate, Testes, B cells

Animal Models for Ischemic Optic Neuropathy or affiliated genes

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MGI Mouse Phenotypes related to Ischemic Optic Neuropathy:

35 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.6VEGFA, ACE, ITGB3, F5, NOS3, AGT
2MP:00053808.5F5, ITGB3, G6PD, VEGFA, EDN1, F2
3MP:00053678.3EDN1, VEGFA, ACE, ITGB3, NOS3, AGT
4MP:00053898.3F2, VEGFA, MTHFR, ACE, ITGB3, NOS3
5MP:00053698.2EDN1, VEGFA, BEX1, ITGB3, NOS3, AGT
6MP:00053908.2F2, EDN1, VEGFA, MTHFR, ITGB3, NOS3
7MP:00036318.1F2, EDN1, VEGFA, G6PD, MTHFR, F5
8MP:00053877.8F2, VEGFA, ACE, ITGB3, CRP, NOS3
9MP:00053787.7F2, VEGFA, G6PD, MTHFR, ACE, ITGB3
10MP:00107687.2G6PD, APOH, VEGFA, EDN1, F2, MTHFR
11MP:00053857.2F2, EDN1, VEGFA, G6PD, ACE, ITGB3
12MP:00053766.1AGTR1, F2, EDN1, GP1BA, VEGFA, APOH

Publications for Ischemic Optic Neuropathy

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Articles related to Ischemic Optic Neuropathy:

(show top 50)    (show all 556)
idTitleAuthorsYear
1
Choroidal thickness in non-arteritic anterior ischemic optic neuropathy. (25488646)
2015
2
Combined anterior ischemic optic neuropathy and hemiretinal artery occlusion during hemodialysis. (25677295)
2015
3
Anterior ischemic optic neuropathy in pediatric peritoneal dialysis: risk factors and therapy. (24488506)
2014
4
Readout-Segmented Diffusion-Weighted Imaging in a Critical Anatomic Area - Diagnosing Posterior Ischemic Optic Neuropathy (PION). (25329511)
2014
5
Efficacy of granulocyte-colony stimulating factor treatment in a rat model of anterior ischemic optic neuropathy. (25317164)
2014
6
Sequential episodes of perioperative ischemic optic neuropathy after hip surgery. (24621863)
2014
7
Severe, early axonal degeneration following experimental anterior ischemic optic neuropathy. (25249599)
2014
8
Intravitreal bevacizumab for the treatment of nonarteritic anterior ischemic optic neuropathy: a prospective trial. (23370417)
2013
9
Sectoral loss of myelin and axons in anterior ischemic optic neuropathy. (23528450)
2013
10
Anterior ischemic optic neuropathy and dialysis: Effect of hypotension. (23772133)
2013
11
Tonic pupil, anterior ischemic optic neuropathy in a teenager with Takayasu arteritis. (24314433)
2013
12
Sustained neuroprotection from a single intravitreal injection of PGJ2 in a rodent model of anterior ischemic optic neuropathy. (24106118)
2013
13
A Study of Prevalence and Risk Factors of Diabetic Retinopathy in Patients with Non-Arteritic Anterior Ischemic Optic Neuropathy (NA-AION). (24171808)
2013
14
Evaluation of inner retinal thickness around the optic disc using optical coherence tomography of a rodent model of nonarteritic ischemic optic neuropathy. (23053634)
2013
15
Impending anterior ischemic optic neuropathy with elements of retinal vein occlusion in a patient on interferon for polycythemia vera. (23152654)
2012
16
You're the flight surgeon: nonarteritic ischemic optic neuropathy. (22764620)
2012
17
Bilateral posterior ischemic optic neuropathy in a patient with severe diabetic ketoacidosis. (21475607)
2011
18
Cellular inflammation in nonarteritic anterior ischemic optic neuropathy and its primate model. (22159678)
2011
19
Ischemic optic neuropathy as a rare but potentially devastating complication of liposuction. (21460684)
2011
20
Changes in cholinergic amacrine cells after rodent anterior ischemic optic neuropathy (rAION). (20847114)
2011
21
Non-arteritic ischemic optic neuropathy followed by intravitreal bevacizumab injection: is there an association? (20534939)
2010
22
A case of decreased visual field after uneventful cataract surgery: nonarteritic anterior ischemic optic neuropathy. (20157417)
2010
23
Clinical profile of patients with nonarteritic anterior ischemic optic neuropathy presented to a referral center from 2003 to 2008. (19722769)
2009
24
Non-arteritic anterior ischemic optic neuropathy and thrombophilia. (18958485)
2009
25
Nonarteritic anterior ischemic optic neuropathy associated with chronic anemia: a case series of myelodysplastic syndrome patients. (19668557)
2009
26
Ischemic optic neuropathy associated with low-dose interferon alfa: report of two cases. (19194130)
2009
27
Visual function in anterior ischemic optic neuropathy: effect of Vision Restoration Therapy--a pilot study. (18207164)
2008
28
Ischemic optic neuropathy. (18826805)
2008
29
A primate model of nonarteritic anterior ischemic optic neuropathy. (18326695)
2008
30
Nonarteritic anterior ischemic optic neuropathy after uneventful phacoemulsification: case report. (17768569)
2007
31
A case of polyarteritis nodosa complicated by left central retinal artery occlusion, ischemic optic neuropathy, and retinal vasculitis. (16575492)
2007
32
Incidence of nonarteritic anterior ischemic optic neuropathy in adult Chinese: the Beijing Eye Study. (17534837)
2007
33
Perioperative posterior ischemic optic neuropathy: review of the literature. (15621075)
2005
34
Bilateral anterior ischemic optic neuropathy after liposuction. (15348986)
2004
35
Anterior ischemic optic neuropathy following off-pump cardiac bypass surgery. (15513001)
2003
36
Recurrent facial palsy occurring with metastatic thymic carcinoid and nonarteritic ischemic optic neuropathy. (12644770)
2003
37
Overlap of optic neuritis and anterior ischemic optic neuropathy. (12601716)
2003
38
Posterior ischemic optic neuropathy related to profound shock after penetrating thoracoabdominal trauma. (12356108)
2002
39
Chlamydia in anterior ischemic optic neuropathy. (12065860)
2002
40
Comparative studies on pattern VECP between patients with ischemic optic neuropathy and optic neuritis. (10990041)
2000
41
Ophthaproblem. Anterior ischemic optic neuropathy. (10424264)
1999
42
Prothrombotic and vascular risk factors in nonarteritic anterior ischemic optic neuropathy. (10599644)
1999
43
Incidence of nonarteritic anterior ischemic optic neuropathy. (9186104)
1997
44
Bilateral nonarteritic anterior ischemic optic neuropathy. (9022091)
1997
45
Anterior ischemic optic neuropathy following neck dissection. (9059874)
1997
46
Anterior ischemic optic neuropathy associated with pulseless disease. (8751345)
1995
47
Postoperative ischemic optic neuropathy. (7726399)
1995
48
Fluorescein angiography in acute nonarteritic anterior ischemic optic neuropathy. (8116751)
1994
49
Risk factors in nonarteritic anterior ischemic optic neuropathy. (2077825)
1990
50
Ischemic optic neuropathy in chronic papilledema. (7362508)
1980

Variations for Ischemic Optic Neuropathy

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Expression for genes affiliated with Ischemic Optic Neuropathy

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Search GEO for disease gene expression data for Ischemic Optic Neuropathy.

Pathways for genes affiliated with Ischemic Optic Neuropathy

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Pathways related to Ischemic Optic Neuropathy according to GeneCards Suite gene sharing:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8F2, GP1BA, F5
2
Show member pathways
Angiogenesis36
9.7NOS3, VEGFA
3
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway58
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB58
Development Angiopoietin Tie2 signaling58
9.7AGTR1, NOS3, F2
4
Show member pathways
9.6ITGB3, GP1BA, F2
5
Show member pathways
thioredoxin pathway36
9.5F2, MTHFR, CRP
6
Show member pathways
9.4AGTR1, AGT, EDN1, F2
7
Show member pathways
9.4AGTR1, AGT, ACE, F2
8
Show member pathways
9.4AGTR1, AGT, NOS3, ACE
99.4EDN1, VEGFA, NOS3
109.4PDE5A, NOS3
11
Show member pathways
9.3F5, ITGB3, VEGFA
12
Show member pathways
9.3VEGFA, ITGB3, NOS3
13
Show member pathways
VEGFR1 specific signals36
9.3VEGFA, ITGB3, NOS3
14
Show member pathways
9.3NOS3, ITGB3, VEGFA
15
Show member pathways
9.2CRP, VEGFA, EDN1
16
Show member pathways
Development EDNRB signaling58
Development ACM2 and ACM4 activation of ERK58
Cell adhesion Integrin inside out signaling58
Development G Proteins mediated regulation MARK ERK signaling58
Signal transduction IP3 signaling58
Development Angiotensin signaling via PYK258
Development EPO induced MAPK pathway58
9.0F2, EDN1, ITGB3, NOS3, AGTR1
17
Show member pathways
7.8F2, GP1BA, VEGFA, ITGB3, PDE5A, F5

Compounds for genes affiliated with Ischemic Optic Neuropathy

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Compounds related to Ischemic Optic Neuropathy according to GeneCards Suite gene sharing:

(show top 50)    (show all 218)
idCompoundScoreTop Affiliating Genes
1benazepril43 49 1211.8ACE, AGTR1, AGT, MTHFR
2chymostatin439.7EDN1, ACE, AGTR1, AGT
3ristocetin439.6GP1BA, F5, F2, ITGB3
4sele439.6AGT, MTHFR, ITGB3, ACE
5kininogen439.6F2, APOH, ACE, F5, GP1BA
6warfarin43 49 24 1212.6MTHFR, ACE, F5, APOH, F2
7irbesartan43 28 49 1212.5AGTR1, AGT, ACE, EDN1
8diltiazem43 28 49 1212.5EDN1, ACE, AGTR1, AGT, F2
9quinapril43 49 1211.5CRP, ACE, EDN1, AGTR1
10lisinopril43 49 24 1212.5VEGFA, ACE, AGTR1, AGT
11vitamin b12439.5APOH, CRP, G6PD, F5, MTHFR
12telmisartan43 28 1211.4AGTR1, CRP, AGT, ACE
138-isoprostane439.4EDN1, APOH, NOS3, CRP, AGTR1
14valsartan43 59 28 1212.3AGT, CRP, AGTR1, EDN1, ACE
15atenolol43 49 28 24 1213.3AGT, AGTR1, EDN1, ACE, CRP
16uric acid43 2410.3APOH, F5, AGTR1, CRP, MTHFR, G6PD
17candesartan43 49 28 1212.3AGT, NOS3, ACE, VEGFA, AGTR1
18phosphatidylserine43 28 1211.2F2, GP1BA, G6PD, ITGB3, F5, APOH
19azathioprine43 2 49 1212.2CRP, G6PD, APOH, MTHFR, NOS3, AGTR1
20carvedilol43 49 28 1212.2NOS3, AGTR1, ACE, VEGFA, EDN1
21epinephrine43 24 1211.2F5, G6PD, GP1BA, F2, EDN1, AGTR1
22losartan43 49 28 1212.2EDN1, ACE, CRP, AGT, AGTR1
23clopidogrel43 49 24 1212.1NOS3, CRP, F2, ACE, ITGB3
24abciximab43 1210.0ITGB3, GP1BA, CRP, F2
25pravastatin43 49 28 24 1213.0MTHFR, ACE, CRP, AGTR1, NOS3
26homocysteine43 2410.0MTHFR, CRP, APOH, F5, NOS3, AGT
27ang ii439.0EDN1, VEGFA, NOS3, AGTR1, AGT, ACE
28hydrochlorothiazide43 28 49 24 1212.9AGT, AGTR1, ACE, CRP
29perindopril43 49 1210.8NOS3, CRP, ACE, VEGFA, AGT, AGTR1
30cyclophosphamide43 49 1210.8F5, NOS3, CRP, APOH, MTHFR, G6PD
31lactate438.7CRP, F5, MT-ND1, APOH, G6PD, F2
32heparin43 28 24 1211.7APOH, F2, AGT, GP1BA, MTHFR, VEGFA
33simvastatin43 49 59 28 24 1213.7VEGFA, F2, AGTR1, F5, NOS3, AGT
34sildenafil28 43 49 24 1212.6PDE5A, ACE, EDN1, VEGFA, NOS3
35atorvastatin43 49 28 24 1212.6F5, CRP, AGT, NOS3, EDN1, VEGFA
36n acetylcysteine438.5F2, CRP, AGTR1, AGT, G6PD, VEGFA
37nitroglycerin43 129.5EDN1, ACE, NOS3, PDE5A, CRP, AGTR1
38folate438.5F5, CRP, PDE5A, NOS3, MTHFR, G6PD
39fibrinogen438.5MTHFR, APOH, GP1BA, AGTR1, ITGB3, CRP
40creatinine438.2APOH, F2, EDN1, G6PD, MTHFR, AGTR1
41acetylcholine43 49 28 24 1212.1AGTR1, AGT, PDE5A, CRP, NOS3, ACE
42glucose438.1GP1BA, AGTR1, APOH, G6PD, AGT, MT-ND1
43alanine438.1F5, F2, GP1BA, MTHFR, MT-ND1, AGTR1
44serine438.0G6PD, F2, AGT, NOS3, F5, ITGB3
45nitric oxide43 24 129.9F5, AGTR1, AGT, EDN1, ACE, PDE5A
46aspirin43 49 28 2410.9ACE, F2, ITGB3, CRP, F5, NOS3
47estrogen437.5ITGB3, MTHFR, G6PD, AGTR1, NOS3, F5
48vegf437.2ITGB3, APOH, EDN1, F5, PDE5A, NOS3
49prostacyclin437.1AGTR1, GP1BA, VEGFA, APOH, ACE, PDE5A
50calcium43 49 24 129.8CRP, EDN1, ITGB3, GP1BA, FLVCR2, ACE

GO Terms for genes affiliated with Ischemic Optic Neuropathy

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Cellular components related to Ischemic Optic Neuropathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.2EDN1, VEGFA, ACE, CRP, F5, AGT
2extracellular spaceGO:00056157.7AGT, F2, EDN1, VEGFA, APOH, ACE

Biological processes related to Ischemic Optic Neuropathy according to GeneCards Suite gene sharing:

(show all 43)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of NAD(P)H oxidase activityGO:003386410.4AGT, AGTR1
2regulation of blood vessel size by renin-angiotensinGO:000203410.4AGT, AGTR1
3regulation of blood coagulationGO:003019310.4F2, GP1BA
4regulation of renal sodium excretionGO:003581310.4AGT, AGTR1
5renin-angiotensin regulation of aldosterone productionGO:000201810.4AGT, AGTR1
6negative regulation of smooth muscle cell apoptotic processGO:003439210.4EDN1, APOH
7negative regulation of fibrinolysisGO:005191810.3F2, APOH
8regulation of renal output by angiotensinGO:000201910.3AGT, ACE
9positive regulation of cholesterol esterificationGO:001087310.3AGT, AGTR1
10low-density lipoprotein particle remodelingGO:003437410.3AGTR1, AGT
11artery smooth muscle contractionGO:001482410.3EDN1, AGT
12regulation of systemic arterial blood pressure by renin-angiotensinGO:000308110.3ACE, AGTR1
13regulation of systemic arterial blood pressure by endothelinGO:000310010.3EDN1, NOS3
14positive regulation of blood coagulationGO:003019410.3F2, APOH
15positive regulation of cellular protein metabolic processGO:003227010.2AGT, AGTR1
16blood coagulation, intrinsic pathwayGO:000759710.2F2, GP1BA, APOH
17negative regulation of platelet activationGO:001054410.2F2, NOS3
18regulation of vasodilationGO:004231210.2ACE, AGTR1
19negative regulation of blood coagulationGO:003019510.2APOH, EDN1
20angiotensin maturationGO:000200310.2ACE, AGT
21positive regulation of reactive oxygen species metabolic processGO:0200037910.1AGTR1, AGT, F2
22positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling paGO:005148210.1EDN1, AGTR1
23positive regulation of macrophage derived foam cell differentiationGO:001074410.1AGTR1, AGT
24positive regulation of renal sodium excretionGO:003581510.1EDN1, AGT
25blood vessel remodelingGO:000197410.0ACE, NOS3, AGT
26negative regulation of lipid storageGO:001088810.0ITGB3, CRP
27nitric oxide mediated signal transductionGO:000726310.0NOS3, AGT
28fibrinolysisGO:00427309.9GP1BA, F2
29negative regulation of macrophage derived foam cell differentiationGO:00107459.8CRP, ITGB3
30regulation of vasoconstrictionGO:00192299.8AGTR1, AGT, ACE, EDN1
31cell surface receptor signaling pathwayGO:00071669.7GP1BA, EDN1, F2
32positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.7AGT, ITGB3, VEGFA
33platelet degranulationGO:00025769.7F5, ITGB3, VEGFA
34positive regulation of vascular endothelial growth factor receptor signaling pathwayGO:00309499.6ITGB3, VEGFA
35positive regulation of protein phosphorylationGO:00019349.6F2, VEGFA, ITGB3
36kidney developmentGO:00018229.6AGTR1, AGT, ACE, VEGFA
37positive regulation of cardiac muscle hypertrophyGO:00106139.5AGT, PDE5A, EDN1
38positive regulation of endothelial cell migrationGO:00105959.4EDN1, VEGFA, ITGB3, AGT
39positive regulation of branching involved in ureteric bud morphogenesisGO:00901909.4AGT, VEGFA
40response to hypoxiaGO:00016669.4CRP, MTHFR, VEGFA, EDN1
41platelet activationGO:00301689.3F2, GP1BA, VEGFA, ITGB3, F5
42positive regulation of MAP kinase activityGO:00434069.2PDE5A, VEGFA, EDN1
43blood coagulationGO:00075968.2F2, GP1BA, VEGFA, ITGB3, PDE5A, F5

Molecular functions related to Ischemic Optic Neuropathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1bradykinin receptor bindingGO:003171110.0AGTR1, ACE
2NADP bindingGO:00506619.7G6PD, MTHFR, NOS3
3vascular endothelial growth factor receptor 2 bindingGO:00431849.4ITGB3, VEGFA
4growth factor activityGO:00080839.4AGT, VEGFA, F2
5platelet-derived growth factor receptor bindingGO:00051619.2ITGB3, VEGFA
6protein bindingGO:00055156.7AGTR1, F2, EDN1, GP1BA, VEGFA, APOH

Products for genes affiliated with Ischemic Optic Neuropathy

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Sources for Ischemic Optic Neuropathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet