MCID: ISC002
MIFTS: 44

Ischemic Optic Neuropathy

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Ischemic Optic Neuropathy

MalaCards integrated aliases for Ischemic Optic Neuropathy:

Name: Ischemic Optic Neuropathy 38
Optic Neuropathy, Ischemic 69

Classifications:



Summaries for Ischemic Optic Neuropathy

MalaCards based summary : Ischemic Optic Neuropathy, also known as optic neuropathy, ischemic, is related to central retinal artery occlusion and nonarteritic anterior ischemic optic neuropathy. An important gene associated with Ischemic Optic Neuropathy is GP1BA (Glycoprotein Ib Platelet Alpha Subunit), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Development Angiotensin activation of ERK. The drugs 4-Aminopyridine and Carbidopa have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and neutrophil, and related phenotypes are homeostasis/metabolism and cardiovascular system

Related Diseases for Ischemic Optic Neuropathy

Diseases related to Ischemic Optic Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 260)
id Related Disease Score Top Affiliating Genes
1 central retinal artery occlusion 29.6 APOH F2 MTHFR SERPINC1
2 nonarteritic anterior ischemic optic neuropathy 12.7
3 arteritic anterior ischemic optic neuropathy 12.3
4 neuropathy 11.1
5 multicentric osteolysis nephropathy 10.9 F5 MTHFR
6 coronary sinus stenosis 10.9 F5 MTHFR
7 variably protease-sensitive prionopathy 10.8 F2 F5
8 amelogenesis imperfecta hypomaturation type 10.8 F5 MTHFR
9 argyria 10.8 ACE F2
10 hypertonia 10.8 MTHFR NOS3
11 fetal hydantoin syndrome 10.8 GP1BA ITGB3
12 porphyria 10.8 F2 MTHFR
13 pars planitis 10.7 ACE MTHFR
14 primary pigmented nodular adrenocortical disease 10.7 F2 F5 MTHFR
15 islet cell tumor 10.7 ACE MTHFR NOS3
16 homologous wasting disease 10.7 F2 F5 MTHFR
17 epithelial predominant pulmonary blastoma 10.7 ACE NOS3 PDE5A
18 lip disease 10.7 F5 NOS3 PDE5A
19 mcgillivray syndrome 10.7 APOH F5
20 atrophic nonflaccid tympanic membrane 10.7 F2 F5 GP1BA
21 accessory deep peroneal nerve 10.6 APOH F5
22 third branchial cleft anomaly 10.6 GP1BA ITGB3
23 immunodeficiency 21 10.6 F2 GP1BA ITGB3
24 charcot-marie-tooth disease 10.6 F2 F5 MTHFR
25 bleeding disorder, platelet-type, 16, autosomal dominant 10.6 F2 GP1BA ITGB3
26 pelizaeus-merzbacher-like disease 10.6 ACE AGT
27 acanthocephaliasis 10.5 F2 MT-ND1
28 acute monocytic leukemia 10.5 GSTM1 GSTT1 MTHFR
29 pregnancy loss, recurrent 1 10.5 APOH F5 MTHFR
30 clitoris cancer 10.5 ACE AGTR1 NOS3
31 cavernous lymphangioma 10.5 APOH F5 MTHFR
32 hypertrichosis of eyelid 10.5 ACE AGTR1 MTHFR
33 asbestos intoxication 10.5 GSTM1 GSTT1
34 retroperitoneal sarcoma 10.5 GSTM1 GSTT1 NOS3
35 retinitis 10.5
36 46,xy ovotesticular disorder of sex development 10.5 APOH F2 F5
37 landau-kleffner syndrome 10.5 APOH F2
38 bile duct cystadenoma 10.5 F2 F5
39 myxomatous pattern testicular yolk sac tumor 10.5 APOH F5 NOS3
40 cervical incompetence 10.4 G6PD GSTM1 GSTT1
41 progressive black carbon hyperpigmentation of infancy 10.4 EDN1 NOS3
42 acute myocardial infarction 10.4 GSTM1 GSTT1 MTHFR
43 citrullinemia, adult-onset type ii 10.4 ACE AGTR1 NOS3
44 lockwood feingold syndrome 10.3 APOH F2 F5 MTHFR
45 thrombomodulin anomalies, familial 10.3 F2 F5 GP1BA ITGB3 MTHFR
46 optic neuritis 10.3
47 neuritis 10.3
48 traumatic glaucoma 10.3 EDN1 NOS3 PDE5A
49 myopia 10.3 ACE EDN1 F2
50 choroiditis 10.2

Graphical network of the top 20 diseases related to Ischemic Optic Neuropathy:



Diseases related to Ischemic Optic Neuropathy

Symptoms & Phenotypes for Ischemic Optic Neuropathy

MGI Mouse Phenotypes related to Ischemic Optic Neuropathy:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.07 ACE AGT AGTR1 APOH EDN1 F2
2 cardiovascular system MP:0005385 10.06 FLVCR2 G6PD ITGB3 NOS3 SERPINC1 ACE
3 mortality/aging MP:0010768 9.93 ACE AGT AGTR1 APOH EDN1 F2
4 nervous system MP:0003631 9.7 SERPINC1 AGT AGTR1 EDN1 F2 F5
5 renal/urinary system MP:0005367 9.17 ACE AGT AGTR1 EDN1 ITGB3 NOS3

Drugs & Therapeutics for Ischemic Optic Neuropathy

Drugs for Ischemic Optic Neuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 93)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
4-Aminopyridine Approved Phase 4 504-24-5 1727
2
Carbidopa Approved Phase 4 28860-95-9 34359 38101
3
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
4
Levodopa Approved Phase 4 59-92-7 6047
5
Tadalafil Approved, Investigational Phase 4 171596-29-5 110635
6
Ephedrine Approved Phase 4 299-42-3 9294
7
Pseudoephedrine Approved Phase 4 90-82-4 7028
8
Choline Approved, Nutraceutical Phase 4 62-49-7 305
9 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1
10 Gastrointestinal Agents Phase 4,Phase 3,Phase 1,Phase 2
11 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
12 Potassium Channel Blockers Phase 4
13 Cytidine Diphosphate Choline Phase 4
14 Nootropic Agents Phase 4
15 Adjuvants, Immunologic Phase 4
16 Antiparkinson Agents Phase 4
17 Aromatic Amino Acid Decarboxylase Inhibitors Phase 4
18 Carbidopa, levodopa drug combination Phase 4
19 Dopamine Agents Phase 4
20 Dopamine agonists Phase 4
21 Neurotransmitter Agents Phase 4,Phase 1
22 Phosphodiesterase 5 Inhibitors Phase 4
23 Phosphodiesterase Inhibitors Phase 4,Phase 2
24 Sildenafil Citrate Phase 4 171599-83-0
25 Vardenafil Dihydrochloride Phase 4
26 Adrenergic Agents Phase 4,Phase 1
27 Adrenergic Agonists Phase 4
28 Adrenergic alpha-2 Receptor Agonists Phase 4
29 Adrenergic alpha-Agonists Phase 4
30 Antihypertensive Agents Phase 4,Phase 3,Phase 1
31 Brimonidine Tartrate Phase 4 70359-46-5
32 Carboxymethylcellulose Sodium Phase 4
33 Cathartics Phase 4
34 Laxatives Phase 4
35 Nasal Decongestants Phase 4
36 Ophthalmic Solutions Phase 4
37 Pharmaceutical Solutions Phase 4
38 Respiratory System Agents Phase 4
39 Tetrahydrozoline Phase 4
40 Vasoconstrictor Agents Phase 4
41
Methylprednisolone Approved, Vet_approved Phase 3,Phase 1,Phase 2 83-43-2 6741
42
Prednisolone Approved, Vet_approved Phase 3,Phase 1,Phase 2 50-24-8 5755
43
Triamcinolone Approved, Vet_approved Phase 3,Phase 1,Phase 2 124-94-7 31307
44
Bosentan Approved, Investigational Phase 3 147536-97-8 104865
45 Antiemetics Phase 3,Phase 1,Phase 2
46 Anti-Inflammatory Agents Phase 3,Phase 1,Phase 2
47 Antineoplastic Agents, Hormonal Phase 3
48 glucocorticoids Phase 3,Phase 1,Phase 2
49 Hormone Antagonists Phase 3,Phase 1,Phase 2
50 Hormones Phase 3,Phase 1,Phase 2

Interventional clinical trials:

(show all 46)

id Name Status NCT ID Phase Drugs
1 A New Medicine to Treat Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) Completed NCT01975324 Phase 4 dalfampridine;Placebo
2 Citicoline Effect on Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) Completed NCT03046693 Phase 4 Group A Citicoline 1000 mg oral tablet;Group B placebo oral tablet
3 Effect of Levodopa-Carbidopa on Visual Function in Patients With Recent-Onset Nonarteritic Anterior Ischemic Optic Neuropathy Completed NCT00432393 Phase 4 levodopa-carbidopa
4 Neural Conduction Along the Visual Pathways After Oral Treatment With Citicoline in Patients With Optic Nerve Diseases Completed NCT00404729 Phase 4 Cytidine-5’-diphosphocholine (Citicoline)
5 PDE5 Inhibitor Use and Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) Recruiting NCT00867815 Phase 4 Diagnostic procedures
6 Preoperative Brimonidine on IOP of Patients Undergoing RALP Recruiting NCT02818816 Phase 4 brimonidine tartrate 0.2%
7 Outcomes of Steroid and Oxygen Therapy Versus Placebo Therapy in Non-arteritic Anterior Ischemic Optic Neuropathy Unknown status NCT02439866 Phase 3 placebo;Intravenous methylprednisolone;normobaric oxygen with face mask
8 Retrobulbar Triamcinolone Acetonide Injection in the Treatment of NA-AION Unknown status NCT02329288 Phase 3 Triamcinolone Acetonide;placebo
9 Ischemic Optic Neuropathy Decompression Trial (IONDT) Completed NCT00000127 Phase 3
10 Phase 2/3, Randomized, Double-Masked, Sham-Controlled Trial of QPI-1007 in Subjects With Acute Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) Recruiting NCT02341560 Phase 2, Phase 3 QPI-1007 Injection - single low dose;QPI-1007 Injection - single high dose;QPI-1007 Injection - multiple low dose;QPI-1007 Injection - multiple high dose
11 ENDOTHELION Study Group: Effect of Bosentan in NAION Patients Recruiting NCT02377271 Phase 3 bosentan;placebo
12 Erythropoietin in Methanol Associated Optic Neuropathy: A Phase-2 Clinical Trial (EPO-MAON Study) Recruiting NCT02376881 Phase 3 Erythropoietin
13 Intravitreal Bevacizumab for Non-Arteritic Anterior Ischemic Optic Neuropathy Unknown status NCT00813059 Phase 2 Intra-vitreal injection of bevacizumab (1.25mg/0.05ml)
14 Comparison of Intravitreal Bevacizumab and Triamcinolone With Placebo Unknown status NCT01330524 Phase 1, Phase 2 Avastin and Triamcinolone
15 Safety and Efficacy Study of RPh201 Treatment of Ischemic Optic Neuropathy (ION). Completed NCT02045212 Phase 2 RPh201;Placebo
16 Neurotomy of Optic Nerve in Non-Arthritic Anterior Ischemic Optic Neuropathy Completed NCT00372021 Phase 1, Phase 2
17 Effects of Moxaverine and Placebo on Ocular Blood Flow Completed NCT00709423 Phase 2 Moxaverine;Moxaverin 150mg;NaCl
18 Traumatic Optic Neuropathy Treatment Trial (TONTT) Completed NCT01783847 Phase 1, Phase 2 Recombinant human erythropoietin (EPO)
19 Safety Assessment of Intravitreal Mesenchymal Stem Cells for Acute Non Arteritic Anterior Ischemic Optic Neuropathy Not yet recruiting NCT03173638 Phase 2
20 Intraocular Pressure During Prone Spinal Surgery Terminated NCT00176722 Phase 2
21 A Phase I Clinical Trial of DARC Unknown status NCT02394613 Phase 1 ANX776
22 Ranibizumab Therapy for Non-arteritic Ischemic Optic Neuropathy Completed NCT00561834 Phase 1 ranibizumab
23 NT-501 CNTF Implant for Ischemic Optic Neuropathy: Safety, Neuroprotection and Neuroenhancement Completed NCT01411657 Phase 1 NT-501 CNTF Implant
24 Safety Study of a Single IVT Injection of QPI-1007 in Chronic Optic Nerve Atrophy and Recent Onset NAION Patients Completed NCT01064505 Phase 1 QPI-1007 at various doses
25 Treatment Study for Ischemic Optic Neuropathy With Opthalmic Timolol Maleate 0.5% Withdrawn NCT01607671 Phase 1 Timolol maleate
26 Ischemic Optic Neuropathy Decompression Trial Followup (IONDT Followup) Unknown status NCT00000126
27 Study of Ocular Blood Flow in Patients With Glaucoma and/or Obstructive Sleep Apnea Syndrome (OSAS) Unknown status NCT00874913
28 Epidemiology Study of Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) Completed NCT01260324
29 Assessment of Visual Field-related Endpoints in Patients With Non-arteritic Ischemic Optic Neuropathy Completed NCT01614158
30 A Study to Determine if There is a Possible Association Between Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) and Phosphodiesterase Type 5 (PDE5) Inhibitors Completed NCT01131104 PDE5 Inhibitors
31 Vision Restoration Therapy (VRT) to Treat Non-Arteritic Anterior Ischemic Optic Neuropathy Completed NCT00140491
32 Safety and Efficacy of Using SightSaver Visual Evoked Potential (VEP) for VEP Monitoring in Prone Spine Surgery Completed NCT02643615 Propofol;Desflurane
33 Intraocular Pressure During Abdominal Aortic Aneurysm (AAA) Repair Completed NCT00450294
34 Determine the Effect of Intraocular Pressure (IOP), Optic Nerve Imaging, Venous Congestion in Volunteers Prone Position 5 Hours Completed NCT00875043
35 Effects of Sevoflurane and Propofol on Light Flashed Evoked Pupillometry Completed NCT01219569 propofol;Sevoflurane
36 Continuous Intraocular Pressure Patterns in Spine Surgery Completed NCT03299400
37 Transcorneal Electrical Stimulation Therapy for Retinal Disease Completed NCT00804102
38 Validation of the GATE Software Completed NCT01265628
39 A Study to Assess Whether PDE5 Inhibitors Increase the Chance of Triggering the Onset of Acute NAION Completed NCT00759174 No intervention
40 Effect of EECP on Anterior Ischemic Optic Neuropathy Recruiting NCT01768260 Aspirin
41 Influence of Oral Treatment With Citicoline for the Prevention of Radiation Optic Neuropathy in Patients Treated for Uveal Melanomas With Proton Beam Therapy Recruiting NCT01338389
42 Biomechanics of Optic Neuropathy Recruiting NCT02982499
43 Stem Cell Ophthalmology Treatment Study II Recruiting NCT03011541
44 Electric Stimulation of the Eye to Improve Vision After Trauma Active, not recruiting NCT02019927
45 Stem Cell Ophthalmology Treatment Study Enrolling by invitation NCT01920867
46 Swept Source Enhanced Depth Imaging Optical Coherence Tomography Not yet recruiting NCT02443129

Search NIH Clinical Center for Ischemic Optic Neuropathy

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Ischemic Optic Neuropathy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Ischemic Optic Neuropathy:
Renexus
Embryonic/Adult Cultured Cells Related to Ischemic Optic Neuropathy:
Human retinal stem cells secreting CNTF PMIDs: 16805711 17508034 16505355 23049090 15684670 12581701 15223826 18830926

Genetic Tests for Ischemic Optic Neuropathy

Anatomical Context for Ischemic Optic Neuropathy

MalaCards organs/tissues related to Ischemic Optic Neuropathy:

39
Eye, Endothelial, Neutrophil, Liver, Testes, B Cells, Prostate

Publications for Ischemic Optic Neuropathy

Articles related to Ischemic Optic Neuropathy:

(show top 50) (show all 692)
id Title Authors Year
1
Visual field improvement in non-arteritic posterior ischemic optic neuropathy in a patient treated with intravenous prostaglandin E1 and steroids. ( 28867757 )
2017
2
Corticosteroid Therapy in Nonarteritic Anterior Ischemic Optic Neuropathy: Response. ( 28759500 )
2017
3
Increased Risk of Stroke in Patients With Nonarteritic Anterior Ischemic Optic Neuropathy: A Nationwide Retrospective CohortA Study. ( 28063480 )
2017
4
Corticosteroid Therapy in Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28759499 )
2017
5
Dalfampridine Treatment in Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28538037 )
2017
6
Automated Evaluation of Choroidal Thickness and Minimum Rim Width Thickness in Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28885450 )
2017
7
Neutrophil to Lymphocyte Ratio in Patients with Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28367045 )
2017
8
Optical coherence tomography angiography of optic disc perfusion in non-arteritic anterior ischemic optic neuropathy. ( 28944200 )
2017
9
Postural effects on intraocular pressure and ocular perfusion pressure in patients with non-arteritic anterior ischemic optic neuropathy. ( 28427356 )
2017
10
OCT angiography of acute non-arteritic anterior ischemic optic neuropathy. ( 28117076 )
2017
11
Nonarteritic Anterior Ischemic Optic Neuropathy Induced Retinal Folds and Deformations. ( 28846776 )
2017
12
Erectile Dysfunction Agents and Nonarteritic Anterior Ischemic Optic Neuropathy. ( 27886893 )
2017
13
Aqueous Humor Cytokines in Patients With Acute Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28438311 )
2017
14
Optical Coherence Tomography Angiography in Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28301863 )
2017
15
Does Nocturnal Hypotension Play a Causal Role in Nonarteritic Anterior Ischemic Optic Neuropathy?: Response. ( 28742641 )
2017
16
Optical coherence tomography angiography in acute arteritic and non-arteritic anterior ischemic optic neuropathy. ( 28861697 )
2017
17
Comparison of the Retinal Microvascular Density Between Open Angle Glaucoma and Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28687846 )
2017
18
Atrial fibrillation in retinal vascular occlusion disease and non-arteritic anterior ischemic optic neuropathy. ( 28771491 )
2017
19
Pathology of Ischemic Optic Neuropathy. ( 28029908 )
2017
20
Role of Nocturnal Arterial Hypotension in Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28742640 )
2017
21
Assessment of nonarteritic anterior ischemic optic neuropathy with intravoxel incoherent motion diffusion-weighted imaging using readout-segmented echo-planar imaging, parallel imaging, and 2D navigator-based reacquisition. ( 28513892 )
2017
22
Increased Risk of Stroke in Patients With Nonarteritic Anterior Ischemic Optic Neuropathy: A Nationwide Retrospective Cohort Study. ( 28093100 )
2017
23
Evaluation of optic nerve head blood flow in normal rats and a rodent model of non-arteritic ischemic optic neuropathy using laser speckle flowgraphy. ( 28786024 )
2017
24
Perioperative nonarteritic anterior ischemic optic neuropathy in Jehovah's Witnesses. ( 28457303 )
2017
25
Nonarteritic Anterior Ischemic Optic Neuropathy and Intraocular Surgery. ( 28108001 )
2017
26
Relative Frequencies of Arteritic and Nonarteritic Anterior Ischemic Optic Neuropathy in an Arab Population. ( 28099197 )
2017
27
Visual outcome following bilateral non-arteritic anterior ischemic optic neuropathy: a systematic review and meta-analysis. ( 28836961 )
2017
28
Use of Intravitreal Dexamethasone in a Case of Anterior Ischemic Optic Neuropathy. ( 28924446 )
2017
29
Retinal Vessel Density in Optical Coherence Tomography Angiography in Optic Atrophy after Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28316838 )
2017
30
Giant cell arteritis with arteritic anterior ischemic optic neuropathy. ( 28523333 )
2017
31
Takayasu arteritis presenting as isolated anterior ischemic optic neuropathy. ( 28389774 )
2017
32
New Treatments for Nonarteritic Anterior Ischemic Optic Neuropathy. ( 27886887 )
2017
33
Aqueous Humor Cytokines in Patients With Acute Nonarteritic Anterior Ischemic Optic Neuropathy. ( 28302535 )
2017
34
BARTONELLA HENSELAE NEURORETINITIS ASSOCIATED WITH CENTRAL RETINAL VEIN OCCLUSION, CHOROIDAL ISCHEMIA, AND ISCHEMIC OPTIC NEUROPATHY. ( 28700390 )
2017
35
High-dose intravenous pulse steroid therapy for optic disc swelling and subretinal fluid in non-arteritic anterior ischemic optic neuropathy. ( 28303068 )
2017
36
Structure-Function Analysis of Nonarteritic Anterior Ischemic Optic Neuropathy and Age-Related Differences in Outcome. ( 28538035 )
2017
37
Prospective Case-crossover Study Investigating the Possible Association Between Nonarteritic Anterior Ischemic Optic Neuropathy and Phosphodiesterase Type 5 Inhibitor Exposure. ( 28336289 )
2017
38
The Effect of Combined Systemic Erythropoietin and Steroid on Non-arteritic Anterior Ischemic Optic Neuropathy: A Prospective Study. ( 28632028 )
2017
39
Sequential development of non-arteritic anterior ischemic optic neuropathy in a patient on hemodialysis. ( 28944153 )
2017
40
SUR1-Associated Mechanisms Are Not Involved in Ischemic Optic Neuropathy 1 Day Post-Injury. ( 27560494 )
2016
41
Comparison of the Deep Optic Nerve Head Structure between Normal-Tension Glaucoma and Nonarteritic Anterior Ischemic Optic Neuropathy. ( 27035660 )
2016
42
Nonarteritic Anterior Ischemic Optic Neuropathy and Erectile Dysfunction Drugs: Is There an Elephant in the Bedroom? ( 27984350 )
2016
43
Cases of Ischemic Optic Neuropathy Associated With Phosphodiesterase-5 Inhibitor Use Reported to the Food and Drug Administration Adverse Event Reporting System. ( 26963573 )
2016
44
The enigma of nonarteritic anterior ischemic optic neuropathy: an update for the comprehensive ophthalmologist. ( 27585212 )
2016
45
Postoperative posterior ischemic optic neuropathy (PION) following right pterional meningioma surgery. ( 27570391 )
2016
46
Temporal Arteritis With Arteritic Anterior Ischemic Optic Neuropathy is Bilateral Until Proven Otherwise: Response. ( 27855129 )
2016
47
Optic Nerve Head Morphology in Nonarteritic Anterior Ischemic Optic Neuropathy Compared to Open-Angle Glaucoma. ( 27603724 )
2016
48
Macular choroidal thickness in non-arteritic ischemic optic neuropathy. ( 26832627 )
2016
49
The Relationship Between Phosphodiesterase-5 Inhibitors and Nonarteritic Anterior Ischemic Optic Neuropathy. ( 26720519 )
2016
50
Clinical and color Doppler imaging features of one patient with occult giant cell arteritis presenting arteritic anterior ischemic optic neuropathy. ( 27516038 )
2016

Variations for Ischemic Optic Neuropathy

Expression for Ischemic Optic Neuropathy

Search GEO for disease gene expression data for Ischemic Optic Neuropathy.

Pathways for Ischemic Optic Neuropathy

Pathways related to Ischemic Optic Neuropathy according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.84 APOH F2 F5 GP1BA ITGB3 NOS3
2
Show member pathways
12.19 AGT AGTR1 EDN1 F2 ITGB3 NOS3
3
Show member pathways
11.76 F2 F5 GP1BA SERPINC1
4 11.6 AGTR1 EDN1 NOS3
5
Show member pathways
11.57 F2 GP1BA ITGB3
6 11.31 ACE AGT AGTR1
7 11.16 EDN1 GSTM1 GSTT1 ITGB3 NOS3
8 10.48 NOS3 PDE5A

GO Terms for Ischemic Optic Neuropathy

Biological processes related to Ischemic Optic Neuropathy according to GeneCards Suite gene sharing:

(show all 36)
id Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.95 AGT EDN1 F2 GP1BA
2 kidney development GO:0001822 9.83 ACE AGT AGTR1
3 blood coagulation GO:0007596 9.77 F2 F5 GP1BA ITGB3 SERPINC1
4 glutathione metabolic process GO:0006749 9.76 G6PD GSTM1 GSTT1
5 positive regulation of endothelial cell migration GO:0010595 9.75 AGT EDN1 ITGB3
6 blood vessel remodeling GO:0001974 9.69 ACE AGT NOS3
7 vasoconstriction GO:0042310 9.67 AGT EDN1
8 nitric oxide mediated signal transduction GO:0007263 9.67 AGT NOS3
9 positive regulation of reactive oxygen species metabolic process GO:2000379 9.67 AGT AGTR1 F2
10 positive regulation of cellular protein metabolic process GO:0032270 9.66 AGT AGTR1
11 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.65 AGT AGTR1
12 regulation of blood vessel diameter GO:0097746 9.65 ACE AGTR1
13 low-density lipoprotein particle remodeling GO:0034374 9.64 AGT AGTR1
14 negative regulation of blood coagulation GO:0030195 9.64 APOH EDN1
15 positive regulation of renal sodium excretion GO:0035815 9.63 AGT EDN1
16 positive regulation of blood coagulation GO:0030194 9.63 APOH F2
17 positive regulation of cardiac muscle hypertrophy GO:0010613 9.63 AGT EDN1 PDE5A
18 angiotensin maturation GO:0002003 9.62 ACE AGT
19 negative regulation of fibrinolysis GO:0051918 9.62 APOH F2
20 regulation of blood pressure GO:0008217 9.62 ACE AGT EDN1 NOS3
21 artery smooth muscle contraction GO:0014824 9.61 AGT EDN1
22 negative regulation of platelet activation GO:0010544 9.61 F2 NOS3
23 blood coagulation, intrinsic pathway GO:0007597 9.61 APOH F2 GP1BA
24 positive regulation of cholesterol esterification GO:0010873 9.6 AGT AGTR1
25 negative regulation of smooth muscle cell apoptotic process GO:0034392 9.59 APOH EDN1
26 regulation of blood vessel size GO:0050880 9.58 AGT EDN1 NOS3
27 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.57 EDN1 NOS3
28 positive regulation of NAD(P)H oxidase activity GO:0033864 9.56 AGT AGTR1
29 hemostasis GO:0007599 9.56 F2 F5 GP1BA SERPINC1
30 renin-angiotensin regulation of aldosterone production GO:0002018 9.55 AGT AGTR1
31 regulation of renal sodium excretion GO:0035813 9.54 AGT AGTR1
32 regulation of blood vessel diameter by renin-angiotensin GO:0002034 9.52 AGT AGTR1
33 regulation of renal output by angiotensin GO:0002019 9.48 ACE AGT
34 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.33 ACE AGT AGTR1
35 regulation of vasoconstriction GO:0019229 9.26 ACE AGT AGTR1 EDN1
36 regulation of blood coagulation GO:0030193 8.92 APOH F2 GP1BA SERPINC1

Molecular functions related to Ischemic Optic Neuropathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 NADP binding GO:0050661 9.13 G6PD MTHFR NOS3
2 bradykinin receptor binding GO:0031711 8.62 ACE AGTR1

Sources for Ischemic Optic Neuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....