Aliases & Classifications for Ischemic Retinopathy

MalaCards integrated aliases for Ischemic Retinopathy:

Name: Ischemic Retinopathy 51

Summaries for Ischemic Retinopathy

MalaCards based summary : Ischemic Retinopathy is related to retinitis and endotheliitis. An important gene associated with Ischemic Retinopathy is PLXND1 (Plexin D1), and among its related pathways/superpathways is Semaphorin interactions. The drugs Ranibizumab and Ciprofloxacin have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and endothelial.

Related Diseases for Ischemic Retinopathy

Graphical network of the top 20 diseases related to Ischemic Retinopathy:



Diseases related to Ischemic Retinopathy

Symptoms & Phenotypes for Ischemic Retinopathy

Drugs & Therapeutics for Ischemic Retinopathy

Drugs for Ischemic Retinopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ranibizumab Approved 347396-82-1 459903
2
Ciprofloxacin Approved, Investigational 85721-33-1 2764
3
Iodine Approved, Investigational 7553-56-2 807
4
Povidone-iodine Approved 25655-41-8
5
Povidone Approved 9003-39-8
6 Angiogenesis Inhibitors
7 Angiogenesis Modulating Agents
8 cadexomer iodine
9 Proxymetacaine

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study to Evaluate the Effects of Ranibizumab (Lucentis) for Patients With Rubeosis and Neovascular Glaucoma Completed NCT01370135 0.5mg intraocular Ranibizumab (Lucentis)
2 Effect of Intravitreal Bone Marrow Stem Cells on Ischemic Retinopathy Active, not recruiting NCT01518842

Search NIH Clinical Center for Ischemic Retinopathy

Genetic Tests for Ischemic Retinopathy

Anatomical Context for Ischemic Retinopathy

MalaCards organs/tissues related to Ischemic Retinopathy:

38
Bone, Bone Marrow, Endothelial, Myeloid, Retina

Publications for Ischemic Retinopathy

Articles related to Ischemic Retinopathy:

(show top 50) (show all 80)
# Title Authors Year
1
An apelin receptor antagonist prevents pathological retinal angiogenesis with ischemic retinopathy in mice. ( 29118394 )
2017
2
Impact of minocycline on vascularization and visual function in an immature mouse model of ischemic retinopathy. ( 28790417 )
2017
3
MicroRNA-126 Reduces Blood-Retina Barrier Breakdown via the Regulation of VCAM-1 and BCL2L11 in Ischemic Retinopathy. ( 28076855 )
2017
4
Silencing of galectin-1 inhibits retinal neovascularization and ameliorates retinal hypoxia in a murine model of oxygen-induced ischemic retinopathy. ( 28257831 )
2017
5
Inhibition or deletion of 11I^-HSD1 does not increase angiogenesis in ischemic retinopathy. ( 28089372 )
2017
6
Interplay between CCN1 and Wnt5a in endothelial cells and pericytes determines the angiogenic outcome in a model of ischemic retinopathy. ( 28469167 )
2017
7
Evaluation of Nonperfused Retinal Vessels in Ischemic Retinopathy. ( 27661854 )
2016
8
Treatment with polyamine oxidase inhibitor reduces microglial activation and limits vascular injury in ischemic retinopathy. ( 27239699 )
2016
9
Global metabolomics reveals metabolic dysregulation in ischemic retinopathy. ( 26617478 )
2016
10
Ischemic retinopathy associated with Crohn's disease. ( 27524921 )
2016
11
Lack of R-Ras Leads to Increased Vascular Permeability in Ischemic Retinopathy. ( 27654416 )
2016
12
Intractable Intradialytic Hypotension with Ischemic Retinopathy. ( 27915344 )
2016
13
S100A4 gene silencing in oxygen-induced ischemic retinopathy inhibits retinal neovascularization via down-regulation of CREB expression. ( 26358273 )
2015
14
ISCHEMIC RETINOPATHY IN NEUROFIBROMATOSIS TYPE 1. ( 26252734 )
2015
15
Epac2-deficiency leads to more severe retinal swelling, glial reactivity and oxidative stress in transient middle cerebral artery occlusion induced ischemic retinopathy. ( 25985753 )
2015
16
Severe ischemic retinopathy in a patient with systemic lupus erythematosus without antiphospholipid syndrome: A case report. ( 25892939 )
2015
17
A platform of integrative studies from in vitro to in vivo experiments: towards drug development for ischemic retinopathy. ( 25661384 )
2015
18
Candesartan stimulates reparative angiogenesis in ischemic retinopathy model: role of hemeoxygenase-1 (HO-1). ( 25420481 )
2015
19
Gemigliptin, a dipeptidyl peptidase-4 inhibitor, inhibits retinal pericyte injury in db/db mice and retinal neovascularization in mice with ischemic retinopathy. ( 26391252 )
2015
20
Ischemic retinopathy and neovascular proliferation secondary to severe head injury. ( 25143848 )
2014
21
Proliferative ischemic retinopathy after arteriovenous malformation embolization in a child with hereditary hemorrhagic telangiectasia. ( 25372443 )
2014
22
Activation of the Endothelin System Mediates Pathological Angiogenesis during Ischemic Retinopathy. ( 25203536 )
2014
23
Angiopoietin-1 guides directional angiogenesis through integrin I+vI^5 signaling for recovery of ischemic retinopathy. ( 24048525 )
2013
24
NADPH Oxidase, NOX1, Mediates Vascular Injury in Ischemic Retinopathy. ( 24053718 )
2013
25
Targeting Neovascularization in Ischemic Retinopathy: Recent Advances. ( 25598837 )
2013
26
Neuronal sirtuin1 mediates retinal vascular regeneration in oxygen-induced ischemic retinopathy. ( 23912262 )
2013
27
Vitreous haemorrhage and ischemic retinopathy in a patient with CADASIL. ( 23064698 )
2013
28
Microglia and interleukin-1I^ in ischemic retinopathy elicit microvascular degeneration through neuronal semaphorin-3A. ( 23766263 )
2013
29
Macrophage metalloelastase (MMP-12) deficiency mitigates retinal inflammation and pathological angiogenesis in ischemic retinopathy. ( 23285156 )
2012
30
Endogenous erythropoietin protects neuroretinal function in ischemic retinopathy. ( 22342523 )
2012
31
Peripheral ischemic retinopathy in Adams-Oliver syndrome. ( 22893088 )
2012
32
Overexpression of 15-lipoxygenase-1 in oxygen-induced ischemic retinopathy inhibits retinal neovascularization via downregulation of vascular endothelial growth factor-A expression. ( 23233787 )
2012
33
Zinc transporter 8 (ZnT8) expression is reduced by ischemic insults: a potential therapeutic target to prevent ischemic retinopathy. ( 23209723 )
2012
34
Hypoxia-induced oxidative stress in ischemic retinopathy. ( 23125893 )
2012
35
Reduced retinal neovascularization, vascular permeability, and apoptosis in ischemic retinopathy in the absence of prolyl hydroxylase-1 due to the prevention of hyperoxia-induced vascular obliteration. ( 21873682 )
2011
36
Increased expression and activity of 12-lipoxygenase in oxygen-induced ischemic retinopathy and proliferative diabetic retinopathy: implications in retinal neovascularization. ( 21228311 )
2011
37
Calpain inhibitors reduce retinal hypoxia in ischemic retinopathy by improving neovascular architecture and functional perfusion. ( 20804843 )
2011
38
Hyperoxia therapy of pre-proliferative ischemic retinopathy in a mouse model. ( 21705685 )
2011
39
Sema3E-PlexinD1 signaling selectively suppresses disoriented angiogenesis in ischemic retinopathy in mice. ( 21505259 )
2011
40
The matricellular protein cysteine-rich protein 61 (CCN1/Cyr61) enhances physiological adaptation of retinal vessels and reduces pathological neovascularization associated with ischemic retinopathy. ( 21212276 )
2011
41
Differential macrophage polarization promotes tissue remodeling and repair in a model of ischemic retinopathy. ( 22355595 )
2011
42
Reversal of ischemic retinopathy following balloon angioplasty of a stenotic ophthalmic artery. ( 20418775 )
2010
43
Moderate GSK-3I^ inhibition improves neovascular architecture, reduces vascular leakage, and reduces retinal hypoxia in a model of ischemic retinopathy. ( 20809259 )
2010
44
Outgrowth endothelial cells: characterization and their potential for reversing ischemic retinopathy. ( 20554606 )
2010
45
Reduced nitro-oxidative stress and neural cell death suggests a protective role for microglial cells in TNFalpha-/- mice in ischemic retinopathy. ( 20107169 )
2010
46
Early intervention of tyrosine nitration prevents vaso-obliteration and neovascularization in ischemic retinopathy. ( 19815813 )
2010
47
Retinal vascular repair and neovascularization are not dependent on CX3CR1 signaling in a model of ischemic retinopathy. ( 19176215 )
2009
48
Stimulating angiogenesis to prevent ischemic retinopathy. ( 19729095 )
2009
49
Vascular endothelial growth factor upregulates expression of annexin A2 in vitro and in a mouse model of ischemic retinopathy. ( 19536308 )
2009
50
Effects of intravitreal morphine administered at different time points after reperfusion in a rabbit model of ischemic retinopathy. ( 18854781 )
2009

Variations for Ischemic Retinopathy

Expression for Ischemic Retinopathy

Search GEO for disease gene expression data for Ischemic Retinopathy.

Pathways for Ischemic Retinopathy

GO Terms for Ischemic Retinopathy

Biological processes related to Ischemic Retinopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.26 PLXND1 SEMA3E
2 regulation of cell shape GO:0008360 9.16 PLXND1 SEMA3E
3 branching involved in blood vessel morphogenesis GO:0001569 8.96 PLXND1 SEMA3E
4 semaphorin-plexin signaling pathway GO:0071526 8.62 PLXND1 SEMA3E

Sources for Ischemic Retinopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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