MCID: ISL001
MIFTS: 51

Islet Cell Tumor malady

Cancer diseases, Endocrine diseases categories

Summaries for Islet Cell Tumor

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Disease Ontology:9 A pancreatic cancer that is located in the pancreatic islet cells.

MalaCards based summary: Islet Cell Tumor, also known as well differentiated pancreatic endocrine tumor, is related to hypoglycemia and cushing's syndrome. An important gene associated with Islet Cell Tumor is IAPP (islet amyloid polypeptide), and among its related pathways are Selected targets of CREB1 and Peptide ligand-binding receptors. The drug dacarbazine and the compounds 111in-pentetreotide and 5-hydroxytryptophan have been mentioned in the context of this disorder. Affiliated tissues include the pancreatic islet cells, pancreas and pancreatic islet, and related mouse phenotypes are cardiovascular system and endocrine/exocrine gland.

Aliases & Classifications for Islet Cell Tumor

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Islet Cell Tumor, Aliases & Descriptions:

Name: Islet Cell Tumor 30 9 43 60
Well Differentiated Pancreatic Endocrine Tumor 60
Malignant Neoplasm of Endocrine Pancreas 60
Malignant Tumor of Endocrine Pancreas 9
Malignant Pancreatic Endocrine Tumor 9
Pancreatic Endocrine Carcinoma 60
 
Pancreatic Endocrine Neoplasm 9
Endocrine Pancreas Cancer 9
Carcinoma Islet Cell 43
Islet Cell Neoplasm 9
Islet Cell Tumour 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Endocrine diseases


Related Diseases for Islet Cell Tumor

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Diseases related to Islet Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 99)
idRelated DiseaseScoreTop Affiliating Genes
1hypoglycemia31.5SST, IAPP, CHGA
2cushing's syndrome31.2SST
3hyperinsulinism30.9SST, IAPP
4diarrhea30.8SST, CHGA, VIP
5zollinger-ellison syndrome30.7MEN1, SST, CHGA
6adenoma30.5CHGA, SST, MEN1
7multiple endocrine neoplasia30.5VIP, CHGA, MEN1
8vipoma30.5SST, VIP
9neurofibromatosis30.5SST, MEN1
10acute pancreatitis30.4SST, IAPP
11acromegaly30.4MEN1, SST, VIP
12thyroid cancer30.4SST, CHGA
13somatostatinoma30.4SST, CHGA, VIP
14hypercalcemia30.3MEN1, IAPP, CHGA, PTHLH
15hyperparathyroidism30.1PTHLH, CHGA, MEN1
16prolactinoma29.9PTHLH, CHGA, SST, MEN1
17glucagonoma29.9VIP, CHGA, SST, MEN1
18insulinoma29.9MEN1, SST, IAPP, CHGA, VIP
19pheochromocytoma29.9VIP, CHGA, IAPP, SST, MEN1
20carcinoid syndrome29.5VIP, CHGA, IAPP, SST, MEN1
21gastrinoma29.4VIP, CHGA, IAPP, SST, MEN1
22adenocarcinoma29.0PTHLH, VIP, CHGA, IAPP, SST, MEN1
23pancreatitis11.2
24pancreatic islet cell tumors11.1
25pheochromocytoma-islet cell tumor syndrome10.6
26intestinal disease10.4SST
27hepatitis10.4
28duodenitis10.4
29hypokalemia10.4
30thyroiditis10.4
31gastrointestinal stromal tumor10.3
32portal hypertension10.3
33tuberous sclerosis10.3
34mahvash disease10.3
35diabetes insipidus10.2
36hyperinsulinemic hypoglycemia, familial, 210.2CHGA, SST
37merkel cell carcinoma10.2CHGA, SST
38lung cancer10.2SST, CHGA
39insulin-like growth factor i10.2
40neurofibromatosis, type 110.2
41pancreatic adenoma10.2
42recurrent acute pancreatitis10.2
43factor vii deficiency10.2SST, CHGA
44pituitary gland disease10.2MEN1, SST
45steatorrhea10.2
46adrenal cortical adenoma10.2MEN1, CHGA
47adenosquamous carcinoma10.1PTHLH, CHGA
48hepatocellular carcinoma10.1
49obesity10.1
50renal cell carcinoma10.1

Graphical network of the top 20 diseases related to Islet Cell Tumor:



Diseases related to islet cell tumor

Symptoms for Islet Cell Tumor

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Drugs & Therapeutics for Islet Cell Tumor

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Drug clinical trials:

Search ClinicalTrials for Islet Cell Tumor

Search NIH Clinical Center for Islet Cell Tumor

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Islet Cell Tumor

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Anatomical Context for Islet Cell Tumor

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MalaCards organs/tissues related to Islet Cell Tumor:

31
Pancreas, Pancreatic islet, Liver, Thyroid, Pituitary, Bone, Breast, B cells, Spinal cord, Lung, Ovary, Testes

FMA organs/tissues related to Islet Cell Tumor:

14
The pancreatic islet cells

Animal Models for Islet Cell Tumor or affiliated genes

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MGI Mouse Phenotypes related to Islet Cell Tumor:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.1MEN1, CHGA, VIP, PTHLH
2MP:00053798.0MEN1, CHGA, VIP, PTHLH
3MP:00053787.9PTHLH, CHGA, IAPP, SST, MEN1
4MP:00053897.8PTHLH, VIP, CHGA, MEN1
5MP:00053877.6PTHLH, VIP, IAPP, SST, MEN1
6MP:00053767.2MEN1, SST, IAPP, CHGA, VIP, PTHLH

Publications for Islet Cell Tumor

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Articles related to Islet Cell Tumor:

(show top 50)    (show all 341)
idTitleAuthorsYear
1
Surgical treatment of pancreatic islet cell tumor: report of 44 cases. (24719954)
2013
2
Management of Non-Islet-Cell Tumor Hypoglycemia: A Clinical Review. (24423303)
2013
3
Non-islet cell tumor-induced hypoglycemia: a report of five cases and brief review of the literature. (24616774)
2013
4
Severe hypoglycemia with "Big"-IGF-2 oversecretion by a giant phyllode tumor of the breast: a rare case of non-islet cell tumor-induced hypoglycemia (NICTH). (22867750)
2012
5
Spectrum of functioning islet cell tumor on multislice computed tomography: experience on 70 patients. (18437902)
2008
6
A minute nonfunctioning islet cell tumor demonstrating malignant features. (15754106)
2005
7
Surgical treatment of nonfunctioning islet cell tumor: report of 41 cases. (15313691)
2004
8
A wolf in sheep's clothing: a non-functioning islet cell tumor of the pancreas masquerading as a microcystic (serous cystic) adenoma. (15254352)
2004
9
Parathyroid hormone-related protein induced coupled increases in bone formation and resorption markers for 7 years in a patient with malignant islet cell tumors. (12009004)
2002
10
Antibodies directed against the E region of pro-insulin-like growth factor-II used to evaluate non-islet cell tumor-induced hypoglycemia. (12324491)
2002
11
Streptozocin for treatment of pancreatic islet cell tumors in dogs: 17 cases (1989-1999). (12322919)
2002
12
Malignant islet cell tumor of the pancreas associated with portal venous thrombus. (11511884)
2001
13
Immunocytochemical localization of prohormone convertase 1/3 and 2 in pancreatic islet cells and islet cell tumors. (11484919)
2001
14
Insulin and somatostatin releasing islet cell tumor caused hypoglycemia. (11334393)
2001
15
Functional pancreatic islet cell tumors with liver metastasis: the role of cytoreductive surgery and transcatheter arterial chemoembolization: a report of five cases. (9884450)
1998
16
Hepatoma with severe non-islet cell tumor hypoglycemia. (9647037)
1998
17
Fine-needle aspiration of pancreatic extramedullary plasmacytoma: possible confusion with islet cell tumor. (7924813)
1994
18
Aneuploid islet cell tumor with late metastasis. (7991294)
1994
19
Giant nonfunctioning islet cell tumor requiring pancreaticoduodenectomy and complete liver revascularization. (8101891)
1993
20
Characterization of insulin-like growth factor II (IGF-II) and IGF binding proteins in patients with non-islet-cell tumor hypoglycemia. (7524924)
1993
21
Duct-islet cell tumor of the pancreas. A case report with immunohistochemical and electron microscopic findings. (2558493)
1989
22
Islet cell tumor presenting as massive upper gastrointestinal bleeding in pregnancy. (2839980)
1988
23
Metastatic islet cell tumor with ACTH, gastrin, and glucagon secretion. Clinical and pathologic studies with multiple therapies. (3032401)
1987
24
Pancreatic islet cell tumors. (3029883)
1987
25
Insulin-producing islet cell tumor in an ectopic pancreas of a red fox (Vulpes vulpes). (6325727)
1984
26
Clonal analysis of insulin and somatostatin secretion and L-dopa decarboxylase expression by a rat islet cell tumor. (6129963)
1983
27
Metastasizing pancreatic islet cell tumors in the rat. (6279704)
1982
28
Rupture of a giant non-functioning pancreatic islet cell tumor following minimal trauma. (6258461)
1981
29
Glucagon secreting clones of rat islet cell tumor. (6257606)
1980
30
Serially transplantable chemically induced rat islet cell tumor. (6250800)
1980
31
Coexistence of bilateral pheochromocytoma and pancreatic islet cell tumor: report of a case and review of the literature. (215301)
1978
32
Remission of hypoglycemia after partial resection of a metastatic islet cell tumor. (208422)
1978
33
Vascular liver nodules caused by an islet cell tumor. (179758)
1976
34
Recent advances in management of functioning islet cell tumor. (4335281)
1972
35
Hydroxyindole-producing tumors of the pancreas. Carcinoid-islet cell tumor and oat cell carcinoma. (4340726)
1972
36
Islet cell tumor with hypoglycemia. (4323689)
1971
37
Adipose tissue lipolysis in golden hamsters with chronic hypoglycemia and hyperinsulinemia due to a transplantable islet cell tumor. (4329446)
1970
38
Pathogenesis of hypoglycemia in hamsters with a transplantable islet-cell tumor. (4303975)
1969
39
Prolonged remission of diarrhea due to nonbeta islet cell tumor of the pancreas by radiotherapy. (4296999)
1968
40
Giant nonfunctioning islet cell tumor. Survival after pancreaticoduodenectomy. (4296368)
1968
41
Functioning metastases from an islet cell tumor of the pancreas. (4289479)
1966
42
PEPTIC ULCER WITH ISLET CELL TUMOR: A REAPPRAISAL. (14215844)
1964
43
Islet cell tumor. Diarrhea, and hypopotassemia (the Zollinger-Ellison syndrome?). (13903135)
1962
44
The syndrome of refractory watery diarrhea and hypokalemia in patients with a non-insulin-secreting islet cell tumor. A further case study and review of the literature. (14476287)
1962
45
Pancreatic islet cell tumors and renal tumors in the male rat following neutron exposure. (14038763)
1961
46
Clinics on endocrine and metabolic diseases. 3. Hyperinsulinism: review of 95 cases of functioning pancreatic islet cell tumors. (13748469)
1960
47
Surgical treatment of the occult islet cell tumor. (13823626)
1959
48
Islet-cell tumor of the pancreas with hyperinsulinism; failure of surgical and alloxan treatment; report of a case. (13268201)
1955
49
Coma and hyperglycemia following islet-cell tumor removal. (14356522)
1955
50
Islet cell tumor of the pancreas: case report. (14838565)
1951

Variations for Islet Cell Tumor

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Expression for genes affiliated with Islet Cell Tumor

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Search GEO for disease gene expression data for Islet Cell Tumor.

Pathways for genes affiliated with Islet Cell Tumor

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Compounds for genes affiliated with Islet Cell Tumor

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Compounds related to Islet Cell Tumor according to GeneCards Suite gene sharing:

(show top 50)    (show all 83)
idCompoundScoreTop Affiliating Genes
1111in-pentetreotide439.8SST, CHGA
25-hydroxytryptophan439.7SST, CHGA
3lanreotide43 2810.7SST, CHGA
4secretoneurin439.5CHGA, VIP
5tyr-3-octreotide439.5SST, VIP
6minigastrin439.5SST, VIP
7dacarbazine43 1210.5CHGA, SST
8streptozotocin439.5CHGA, IAPP, SST
9c-peptide439.5SST, IAPP, CHGA
10vanillylmandelic acid43 2410.5VIP, CHGA
11spantide439.5SST, VIP
12cyclophosphamide43 49 1211.2SST, CHGA, PTHLH
13catecholamine439.1IAPP, CHGA, VIP
14mibg439.1SST, CHGA, VIP
15oxyntomodulin43 5910.1VIP, CHGA, SST
165-hydroxyindoleacetic acid43 2410.1VIP, CHGA, SST
17propranolol43 28 49 24 1213.1SST, CHGA, VIP
18trifluoroethanol43 1210.0PTHLH, VIP, IAPP
19caffeine43 28 2 49 24 1214.0VIP, CHGA, SST
20carbachol43 28 1211.0VIP, CHGA, SST
215-hydroxytryptamine439.0SST, CHGA, VIP
22acth438.9VIP, CHGA, SST
23gnrh438.9SST, CHGA, VIP
24vitamin d438.9MEN1, CHGA, PTHLH
25gaba438.8VIP, CHGA, SST
26thyroxine43 249.8PTHLH, VIP, SST
27epinephrine43 24 1210.7VIP, CHGA, IAPP, SST
28histamine43 28 2410.7SST, IAPP, CHGA, VIP
29dopamine43 28 24 1211.6VIP, CHGA, IAPP, SST
30forskolin43 49 1210.6PTHLH, VIP, CHGA, IAPP
31ibmx43 59 2810.5SST, IAPP, VIP, PTHLH
32cyclic amp43 249.5PTHLH, VIP, CHGA, IAPP
33octreotide43 59 28 1211.5PTHLH, VIP, CHGA, SST
34nifedipine43 28 49 1211.5PTHLH, VIP, CHGA, SST
35thymidine43 249.5PTHLH, VIP, IAPP, MEN1
36nitric oxide43 24 1210.4IAPP, CHGA, VIP, PTHLH
37glucose438.4SST, IAPP, CHGA, PTHLH
38indomethacin43 28 59 1211.3PTHLH, VIP, IAPP
39estrogen438.1MEN1, CHGA, VIP, PTHLH
40isoproterenol43 129.1SST, IAPP, CHGA, VIP, PTHLH
41norepinephrine43 24 1210.1PTHLH, VIP, CHGA, IAPP, SST
42acetylcholine43 49 28 24 1212.1SST, IAPP, CHGA, VIP, PTHLH
43lactate438.1PTHLH, VIP, CHGA, IAPP, SST
44adenylate438.1PTHLH, VIP, CHGA, IAPP, SST
45testosterone43 59 24 1211.1PTHLH, VIP, CHGA, IAPP, SST
46dexamethasone43 49 28 1211.1PTHLH, VIP, CHGA, IAPP, SST
47arginine438.1PTHLH, VIP, CHGA, IAPP, SST
48serine438.0PTHLH, VIP, CHGA, IAPP, MEN1
49vegf437.9MEN1, SST, CHGA, VIP, PTHLH
50calcium43 49 24 1210.8PTHLH, VIP, CHGA, IAPP, MEN1

GO Terms for genes affiliated with Islet Cell Tumor

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Cellular components related to Islet Cell Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:00430258.7SST, IAPP, VIP
2extracellular regionGO:00055767.3SST, IAPP, CHGA, VIP, PTHLH

Biological processes related to Islet Cell Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1osteoblast developmentGO:00020769.3MEN1, PTHLH
2negative regulation of sequence-specific DNA binding transcription factor activityGO:00434339.3MEN1, PTHLH
3cell-cell signalingGO:00072678.8SST, IAPP, PTHLH
4negative regulation of cell proliferationGO:00082858.5PTHLH, SST, MEN1

Molecular functions related to Islet Cell Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00051798.1SST, IAPP, VIP, PTHLH

Products for genes affiliated with Islet Cell Tumor

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Sources for Islet Cell Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet