MCID: ISL001
MIFTS: 50

Islet Cell Tumor malady

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Islet Cell Tumor

Aliases & Descriptions for Islet Cell Tumor:

Name: Islet Cell Tumor 38 12 52 14 69
Well Differentiated Pancreatic Endocrine Tumor 69
Malignant Neoplasm of Endocrine Pancreas 69
Malignant Tumor of Endocrine Pancreas 12
Malignant Pancreatic Endocrine Tumor 12
Pancreatic Endocrine Carcinoma 69
Pancreatic Endocrine Neoplasm 12
Endocrine Pancreas Cancer 12
Carcinoma Islet Cell 52
Islet Cell Neoplasm 12
Adenoma, Islet Cell 42
Islet Cell Tumour 12

Classifications:



Summaries for Islet Cell Tumor

Disease Ontology : 12 A pancreatic cancer that is located in the pancreatic islet cells.

MalaCards based summary : Islet Cell Tumor, also known as well differentiated pancreatic endocrine tumor, is related to pheochromocytoma and pancreatic islet cell tumors. An important gene associated with Islet Cell Tumor is SST (Somatostatin), and among its related pathways/superpathways are Signaling by GPCR and G alpha (s) signalling events. The drugs Everolimus and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include pancreas, pancreatic islet and liver, and related phenotypes are cardiovascular system and endocrine/exocrine gland

Related Diseases for Islet Cell Tumor

Diseases related to Islet Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 170)
id Related Disease Score Top Affiliating Genes
1 pheochromocytoma 29.2 CALCA CHGA MEN1 SST VIP
2 pancreatic islet cell tumors 12.3
3 pheochromocytoma-islet cell tumor syndrome 12.1
4 pancreatic neuroendocrine tumor 11.5
5 insulinoma 11.3
6 somatostatinoma 11.3
7 mahvash disease 11.1
8 vipoma 11.0
9 pancreatic endocrine carcinoma 10.9
10 pancreatitis 10.7
11 hypoglycemia 10.5
12 nutritional optic neuropathy 10.3 GAST SST
13 cherubism 10.3 GAST SST
14 myocardial stunning 10.3 GAST SST
15 shaken baby syndrome 10.3 INS SST
16 tricuspid valve stenosis 10.3 GAST SST
17 alpha-heavy chain disease 10.3 CALCA GAST
18 vein disease 10.3 GAST INS
19 color blindness 10.3 GAST SST
20 peripheral degeneration of cornea 10.3 INS SST
21 lung occult small cell carcinoma 10.3 CALCA SST
22 protein s deficiency 10.2 INS SST
23 photoparoxysmal response 3 10.2 INS SST
24 uterine ligament cancer 10.2 MEN1 SST
25 early-onset parkinson disease 10.2 MEN1 SST
26 oculocutaneous albinism 10.2 CHGA SST
27 autoimmune pancreatitis 10.2 CHGA GAST
28 breast secretory carcinoma 10.2 CHGA SST
29 breast malignant eccrine spiradenoma 10.2 GAST MEN1
30 gastric duplication cysts 10.2 CHGA GAST
31 granulocytopenia 10.2 CHGA GAST
32 tabes dorsalis 10.2 MEN1 SST
33 adult botryoid rhabdomyosarcoma 10.2 CHGA SST
34 pulmonary neuroendocrine tumor 10.2 MEN1 SST
35 hemopericardium 10.2 CALCA INS
36 hirschsprung disease 1 10.2 CALCA MEN1
37 perineural angioma 10.2 CALCA CHGA
38 parietal lobe neoplasm 10.2 CALCA CHGA
39 merkel cell carcinoma 10.2 INS SST
40 waardenburg syndrome, type 4b 10.2 CALCA PTHLH
41 acinar cell cystadenocarcinoma 10.2 CHGA GAST
42 hypogonadism cardiomyopathy 10.2 CALCA PTHLH
43 neutral lipid storage disease with myopathy 10.2 IGF2 INS
44 neuroretinitis 10.2 MEN1 SST
45 maroteaux stanescu cousin syndrome 10.2 CALCA PTHLH
46 breast fibroadenoma 10.2 IGF2 INS
47 growth retardation hydrocephaly lung hypoplasia 10.1 CHGA INS
48 retinal vascular occlusion 10.1 GAST INS SST
49 diarrhea 10.1
50 epidermolysis bullosa, junctional, herlitz type 10.1 CALCA MEN1

Graphical network of the top 20 diseases related to Islet Cell Tumor:



Diseases related to Islet Cell Tumor

Symptoms & Phenotypes for Islet Cell Tumor

MGI Mouse Phenotypes related to Islet Cell Tumor:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.88 CHGA IGF2 INS MEN1 PTHLH VIP
2 endocrine/exocrine gland MP:0005379 9.87 GAST IGF2 INS MEN1 PTHLH VIP
3 homeostasis/metabolism MP:0005376 9.86 CHGA GAST IGF2 INS MEN1 PTHLH
4 digestive/alimentary MP:0005381 9.85 GAST IGF2 INS MEN1 PTHLH SST
5 immune system MP:0005387 9.7 GAST IGF2 INS MEN1 PTHLH SST
6 mortality/aging MP:0010768 9.56 CHGA GAST IGF2 INS MEN1 PTHLH
7 reproductive system MP:0005389 9.1 CHGA IGF2 INS MEN1 PTHLH VIP

Drugs & Therapeutics for Islet Cell Tumor

Drugs for Islet Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 226)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Everolimus Approved Phase 4,Phase 3,Phase 2,Phase 1 159351-69-6 6442177
2
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
3
Sirolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 53123-88-9 5284616 6436030 46835353
4
Pancrelipase Approved Phase 4,Phase 3,Phase 2,Phase 1 53608-75-6
5
Etanercept Approved, Investigational Phase 4,Phase 1,Phase 2 185243-69-0
6
Sunitinib Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 341031-54-7, 557795-19-4 5329102
7
Somatostatin Approved Phase 4,Phase 3,Phase 2,Phase 1 38916-34-6, 51110-01-1 53481605
8
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
9
Zinc Approved Phase 4 7440-66-6 32051 23994
10 Liver Extracts Phase 4,Phase 3,Phase 2,Phase 1
11 pancreatic polypeptide Phase 4,Phase 2,Phase 3,Phase 1
12 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1
13 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1
14 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Phase 1
15 Antifungal Agents Phase 4,Phase 3,Phase 2,Phase 1
16 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
17 Immunosuppressive Agents Phase 4,Phase 2,Phase 3,Phase 1
18 pancreatin Phase 4,Phase 3,Phase 2,Phase 1
19 Analgesics Phase 4,Phase 3,Phase 1,Phase 2
20 Analgesics, Non-Narcotic Phase 4,Phase 1,Phase 2
21 Anti-Inflammatory Agents Phase 4,Phase 1,Phase 2
22 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 1,Phase 2
23 Antirheumatic Agents Phase 4,Phase 1,Phase 2
24 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 1,Phase 2
25 Angiogenesis Inhibitors Phase 4,Phase 2,Phase 3,Phase 1
26 Angiogenesis Modulating Agents Phase 4,Phase 2,Phase 3,Phase 1
27 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
28 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
29 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
30 Hypoglycemic Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
31 Antacids Phase 4,Phase 3,Phase 2
32 Anti-Ulcer Agents Phase 4,Phase 3,Phase 2
33
Dexlansoprazole Phase 4 138530-94-6, 103577-45-3 9578005
34
Proton pump inhibitors Phase 4,Phase 3,Phase 2
35 insulin Phase 4,Phase 2
36 Insulin, Globin Zinc Phase 4,Phase 2
37 Fluorodeoxyglucose F18 Phase 4,Phase 2
38 Alpha 1-Antitrypsin Phase 4
39 HIV Protease Inhibitors Phase 4,Phase 2
40
protease inhibitors Phase 4,Phase 2
41 Protein C Phase 4
42 Protein C Inhibitor Phase 4
43 Serine Proteinase Inhibitors Phase 4
44 Trypsin Inhibitors Phase 4
45 serine Nutraceutical Phase 4
46
Bevacizumab Approved, Investigational Phase 2, Phase 3 216974-75-3
47
Fluorouracil Approved Phase 2, Phase 3, Phase 1 51-21-8 3385
48
Levoleucovorin Approved Phase 2, Phase 3,Phase 1 68538-85-2
49
Oxaliplatin Approved, Investigational Phase 2, Phase 3,Phase 1 61825-94-3 5310940 9887054 6857599, 9887054 43805
50
Exenatide Approved, Investigational Phase 2, Phase 3,Phase 1,Early Phase 1 141758-74-9 15991534

Interventional clinical trials:

(show top 50) (show all 191)
id Name Status NCT ID Phase
1 Disease-Specific Questionnaire in Assessing Quality of Life in Patients With Gastrointestinal-Related Neuroendocrine Tumors Unknown status NCT00454376 Phase 4
2 Treatment of Zollinger-Ellison Syndrome With Prevacid Completed NCT00204373 Phase 4
3 Phase IV Study of the Safety and Efficacy of Everolimus in Adult Patients With Progressive pNET in China Recruiting NCT02842749 Phase 4
4 Nonfunctional Pancreatic NET and PET Imaging Recruiting NCT02621541 Phase 4
5 Anti-inflammatory Therapy to Improve Outcomes After TPIAT Recruiting NCT02713997 Phase 4
6 A Study Of The Efficacy And Safety Of Sunitinib In Patients With Advanced Well-Differentiated Pancreatic Neuroendocrine Tumors Active, not recruiting NCT01525550 Phase 4
7 Clinical Effectiveness of Serum Chromogranin A Levels on Diagnostic of Pancreatic Neuroendocrine Tumors Active, not recruiting NCT02759718 Phase 4
8 Pasireotide Treatment for Neuroendocrine Tumor Withdrawn NCT02779257 Phase 4
9 Combination Chemotherapy and Bevacizumab in Treating Patients With Advanced Neuroendocrine Tumors Unknown status NCT00227617 Phase 2, Phase 3
10 Study of Lanreotide Autogel 120 mg in Patients With Non-functioning Entero- Pancreatic Endocrine Tumour Completed NCT00842348 Phase 3
11 Study of Lanreotide Autogel in Non-functioning Entero-pancreatic Endocrine Tumours Completed NCT00353496 Phase 3
12 Efficacy and Safety of Everolimus (RAD001) Compared to Placebo in Patients With Advanced Neuroendocrine Tumors Completed NCT00510068 Phase 3
13 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3
14 Safety and Efficacy Study of In-111 Pentetreotide to Treat Neuroendocrine Tumors Completed NCT00442533 Phase 2, Phase 3
15 Esomeprazole In Patients With Gastric Acid Hypersecretory States Including Idiopathic Hypersecretion and Zollinger-Ellison Syndrome Completed NCT00079833 Phase 3
16 A Phase I/III Study of D961H 10 mg and 20 mg in Japanese Paediatric Patients With Gastrointestinal Acid Related Diseases Completed NCT02153398 Phase 3
17 Phase III Study of Sulfatinib in Treating Advanced Pancreatic Neuroendocrine Tumors Recruiting NCT02589821 Phase 3
18 A Study Evaluating Lanreotide as Maintenance Therapy in Patients With Non-Resectable Duodeno-Pancreatic Neuroendocrine Tumors (REMINET) Recruiting NCT02288377 Phase 2, Phase 3
19 New Imaging Procedure for the Localisation of Insulinoma and Transplanted Islet Cells Recruiting NCT02127541 Phase 2, Phase 3
20 Efficacy and Safety of Everolimus and (STZ-5FU) Given One Upfront the Other Upon Progression in Advanced pNET Recruiting NCT02246127 Phase 3
21 Efficacy and Safety of Radiofrequency Ablation in Pancreatic Neuroendocrine and Cystic Tumor Recruiting NCT02330497 Phase 3
22 18F-DOPA PET Imaging: an Evaluation of Biodistribution and Safety Recruiting NCT03042416 Phase 3
23 Clinical Evaluation Of Needle-based Confocal Laser Endomicroscopy in The Lymph Nodes Along With Masses and Cystic Tumors of the Pancreas Active, not recruiting NCT01563133 Phase 3
24 Non-functioning Pancreatic Neuroendocrine Tumors in MEN1: Somatostatin Analogs Versus NO Treatment Not yet recruiting NCT02705651 Phase 3
25 A Study Of Sunitinib Compared To Placebo For Patients With Advanced Pancreatic Islet Cell Tumors Terminated NCT00428597 Phase 3
26 Activity and Safety of Everolimus+Octreotide LAR+Metformin in Advanced Pancreatic Well-differentiated NETs Unknown status NCT02294006 Phase 2
27 68-Ga-labeled Octreotide Analogues PET in Duodenal-pancreatic Neuroendocrine Tumours Unknown status NCT01673906 Phase 2
28 Single Arm Trial With Combination of Everolimus and Letrozole in Treatment of Platinum Resistant Relapse or Refractory or Persistent Ovarian Cancer/Endometrial Cancer Unknown status NCT02188550 Phase 2
29 RAD001 and Erlotinib in Patients With Neuroendocrine Tumors Unknown status NCT00843531 Phase 2
30 Islet Transplantation in Type 1 Diabetic Patients Using the Edmonton Protocol of Steroid Free Immunosuppression Unknown status NCT00566813 Phase 1, Phase 2
31 Interferon and Octreotide to Treat Zollinger-Ellison Syndrome and Advanced Non-B Islet Cell Cancer Completed NCT00001228 Phase 2
32 Combination Chemotherapy in Patients With Zollinger-Ellison Syndrome and Tumors of the Pancreas Completed NCT00001165 Phase 2
33 Chemotherapy Plus Endostatin in Advanced Pancreatic Neuroendocrine Tumor Completed NCT01845675 Phase 2
34 BEZ235 Phase II Trial in Patients With Advanced Pancreatic Neuroendocrine Tumors (pNET) After Failure of mTOR Inhibitor Therapy. Completed NCT01658436 Phase 2
35 Efficacy And Safety Of Sunitinib In Patients With Advanced Well-Differentiated Pancreatic Neuroendocrine Tumors Completed NCT01121562 Phase 2
36 Capecitabine and Streptozocin With or Without Cisplatin in Treating Patients With Unresectable or Metastatic Neuroendocrine Tumors Completed NCT00602082 Phase 2
37 Phase II Study of Sunitinib Malate Following Hepatic Artery Embolization Completed NCT00434109 Phase 2
38 Thalidomide in Treating Patients With Metastatic Neuroendocrine Tumors Completed NCT00027638 Phase 2
39 PS-341 in Treating Patients With Metastatic Neuroendocrine Tumors Completed NCT00017199 Phase 2
40 Combination Chemotherapy as First-Line Therapy in Treating Patients With Locally Advanced or Metastatic Neuroendocrine Tumors of the Duodenum or Pancreas That Cannot Be Removed By Surgery Completed NCT00416767 Phase 2
41 AMG 706 and Octreotide in Treating Patients With Low-Grade Neuroendocrine Tumors Completed NCT00427349 Phase 2
42 Isolated Hepatic Perfusion With Melphalan in Treating Patients With Primary Unresectable Liver Cancer or Liver Metastases Completed NCT00019786 Phase 2
43 Sorafenib Tosylate in Treating Patients With Progressive Metastatic Neuroendocrine Tumors Completed NCT00131911 Phase 2
44 Gefitinib in Treating Patients With Progressive Metastatic Neuroendocrine Tumors Completed NCT00075439 Phase 2
45 Pazopanib Hydrochloride in Treating Patients With Advanced Neuroendocrine Cancer Completed NCT00454363 Phase 2
46 Safety/Efficacy of Everolimus in Adults With Advanced Pancreatic Neuroendocrine Cancer Not Responsive to Chemotherapy Completed NCT00363051 Phase 2
47 A Study of IMC-A12 in Islet Cell Cancer Completed NCT00781911 Phase 2
48 RAD001 Plus Octreotide Depot in Metastatic or Unresectable Low Grade Neuroendocrine Carcinoma Completed NCT00113360 Phase 2
49 68Ga-OPS202 Study for Diagnostic Imaging of GEP NET Completed NCT02162446 Phase 1, Phase 2
50 Pazopanib as Single Agent in Advanced NETs Completed NCT01280201 Phase 2

Search NIH Clinical Center for Islet Cell Tumor

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: adenoma, islet cell

Genetic Tests for Islet Cell Tumor

Anatomical Context for Islet Cell Tumor

MalaCards organs/tissues related to Islet Cell Tumor:

39
Pancreas, Pancreatic Islet, Liver, Thyroid, Pituitary, B Cells, Breast

The Foundational Model of Anatomy Ontology organs/tissues related to Islet Cell Tumor:

18
The Pancreatic Islet Cells

Publications for Islet Cell Tumor

Articles related to Islet Cell Tumor:

(show top 50) (show all 347)
id Title Authors Year
1
Non-islet cell tumor hypoglycemia caused by a big insulin-like growth factor II- producing hepatocellular carcinoma:an autopsy case report. ( 27916774 )
2016
2
Non-islet cell tumor hypoglycemia caused by intrathoracic solitary fibrous tumor: a case report. ( 27061182 )
2016
3
Non-Islet Cell Tumor Hypoglycemia Is Caused by Big IGF-II in a Patient with a Carcinosarcoma of the Uterus. ( 26666605 )
2015
4
Fatal hepatitis B reactivation in a patient with islet cell tumor on octreotide and sirolimus. ( 26487953 )
2015
5
Multiple hepatocellular adenomas presenting in a male 8 years post-pancreaticoduodenectomy for islet cell tumor of the pancreas. ( 25810673 )
2015
6
The Transformation of a Nonfunctioning Islet Cell Tumor of the Pancreas into a Proinsulinoma under Conditions of Lung Metastasis. ( 25832942 )
2015
7
A 94-year-old man with recurrent hypoglycemia caused by non-islet cell tumor hypoglycemia (NICTH). ( 25780362 )
2014
8
Bioactive insulin-like growth factors as a possible molecular target for non-islet cell tumor hypoglycemia. ( 25535894 )
2014
9
Nonfunctional islet cell tumor of the pancreas in a patient with tuberous sclerosis: a case report with literature review. ( 24678435 )
2014
10
Characterization of a pancreatic islet cell tumor in a polar bear (Ursus maritimus). ( 25273481 )
2014
11
Surgical treatment of pancreatic islet cell tumor: report of 44 cases. ( 24719954 )
2013
12
Gastric neuroendocrine carcinoma with non-islet cell tumor hypoglycemia associated with enhanced production of insulin-like growth factor II. ( 23545670 )
2013
13
Metastatic Insulinoma Following Resection of Nonsecreting Pancreatic Islet Cell Tumor: A Case Report and Review of the Literature. ( 26425568 )
2013
14
Non-islet cell tumor hypoglycemia associated with recurrent carcinosarcoma of the ovary. ( 23512392 )
2013
15
GPR119 expression in normal human tissues and islet cell tumors: evidence for its islet-gastrointestinal distribution, expression in pancreatic beta and alpha cells, and involvement in islet function. ( 22883930 )
2013
16
Non-Islet Cell Tumor-Induced Hypoglycemia Associated with Macronodular Pulmonary Metastases from Poorly Differentiated Thyroid Carcinoma. ( 23697382 )
2013
17
Nesidioblastosis and Pancreatic Non-functioning Islet Cell Tumor in an Adult with Type 2 Diabetes Mellitus. ( 24255640 )
2013
18
Non-islet cell tumor-induced hypoglycemia: a report of five cases and brief review of the literature. ( 24616774 )
2013
19
Management of Non-Islet-Cell Tumor Hypoglycemia: A Clinical Review. ( 24423303 )
2013
20
Non-islet cell tumor hypoglycemia at the second recurrence of malignant solitary fibrous tumor in the retroperitoneum and pelvis: a case report. ( 22949904 )
2012
21
Sorafenib inhibits tumor growth and improves survival in a transgenic mouse model of pancreatic islet cell tumors. ( 23346016 )
2012
22
Recurrent solitary fibrous tumor of the pleura with malignant transformation and non-islet cell tumor-induced hypoglycemia due to paraneoplastic overexpression and secretion of high-molecular-weight insulin-like growth Factor II. ( 23207122 )
2012
23
Severe hypoglycemia with "Big"-IGF-2 oversecretion by a giant phyllode tumor of the breast: a rare case of non-islet cell tumor-induced hypoglycemia (NICTH). ( 22867750 )
2012
24
Gastrointestinal stromal tumor of the pelvic soft tissue presenting with symptomatic hypoglycemia: A case report and brief review of current literature of non-islet cell tumor-induced hypoglycemia. ( 24371628 )
2012
25
Pancreatic and peri-pancreatic lesions mimic pancreatic islet cell tumor in multidetector computed tomography. ( 21740785 )
2011
26
Retrospective Review of Cross Sectional Imaging Findings of Pancreatic Non-functional Islet Cell Tumor (NFICT) and its Hepatic Metastases. ( 22043378 )
2011
27
Non-islet cell tumor hypoglycemia associated with uterine leiomyomata. ( 21550955 )
2011
28
Diabetic ketoacidosis with concurrent pancreatitis, pancreatic I^ islet cell tumor, and adrenal disease in an obese ferret (Mustela putorius furo). ( 21838985 )
2011
29
Metastatic pancreatic polypeptide-secreting islet cell tumor in a dog. ( 20698942 )
2010
30
Systematic comparison of sporadic and syndromic pancreatic islet cell tumors. ( 20660572 )
2010
31
Diffusion weighted MR imaging of pancreatic islet cell tumors. ( 19264435 )
2010
32
A case of gastric cancer with non-islet cell tumor hypoglycemia detected by insulin-like growth factor II. ( 20618739 )
2010
33
Hepatic abscess after yttrium-90 radioembolization for islet-cell tumor hepatic metastasis. ( 19688373 )
2010
34
Homozygous P86S mutation of the human glucagon receptor is associated with hyperglucagonemia, alpha cell hyperplasia, and islet cell tumor. ( 19657311 )
2009
35
Non-islet cell tumor hypoglycemia. ( 19345293 )
2009
36
Insulinoma with six islet cell tumors associated with severe hypoglycemia. ( 19525595 )
2009
37
Pancreatic islet cell tumor secreting insulin-like growth factor type-II in a dog. ( 19780935 )
2009
38
Successful control of intractable hypoglycemia using rapamycin in an 86-year-old man with a pancreatic insulin-secreting islet cell tumor and metastases. ( 19567519 )
2009
39
Islet cell tumor of the pancreas: increasing diagnosis after instituting ultrasonography-guided fine needle aspiration. ( 18323274 )
2008
40
Non-islet-cell tumor hypoglycemia and lactic acidosis in a child with congenital HIV and Burkitt's lymphoma. ( 18825882 )
2008
41
Spontaneous pancreatic islet cell tumor in a black and white colobus monkey (Colobus guereza kikuyuensis). ( 18269522 )
2008
42
Successful treatment of non-islet cell tumor hypoglycemia in hepatocellular carcinoma with doxorubicin. ( 18278497 )
2008
43
Spectrum of functioning islet cell tumor on multislice computed tomography: experience on 70 patients. ( 18437902 )
2008
44
Hypoglycemia associated with the production of insulin-like growth factor II in a pancreatic islet cell tumor: a case report. ( 18490836 )
2008
45
Nesidioblastosis and hyperplasia of alpha cells, microglucagonoma, and nonfunctioning islet cell tumor of the pancreas: review of the literature. ( 18437091 )
2008
46
Differential diagnosis of non-functional islet cell tumor and pancreatic carcinoma with sonography. ( 17412543 )
2007
47
Severe hypoglycemia induced by IGF-II producing non-islet cell tumor. ( 17603253 )
2007
48
Solitary fibrous tumor associated with non-islet cell tumor hypoglycemia. ( 17588442 )
2007
49
Non-islet cell tumor hypoglycemia in a patient with poorly differentiated thyroid cancer. ( 17274758 )
2007
50
Generation and characterization of islet cell tumor in pTet-on/pTRE-SV40Tag double-transgenic mice model. ( 17697978 )
2007

Variations for Islet Cell Tumor

Expression for Islet Cell Tumor

Search GEO for disease gene expression data for Islet Cell Tumor.

Pathways for Islet Cell Tumor

Pathways related to Islet Cell Tumor according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.45 CALCA GAST IGF2 INS MEN1 PTHLH
2 11.3 CALCA PTHLH VIP
3 10.98 IGF2 INS
4 9.47 GAST VIP

GO Terms for Islet Cell Tumor

Cellular components related to Islet Cell Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 CALCA CHGA GAST IGF2 INS PTHLH
2 extracellular region GO:0005576 9.23 CALCA CHGA GAST IGF2 INS PTHLH

Biological processes related to Islet Cell Tumor according to GeneCards Suite gene sharing:

(show all 13)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.71 IGF2 INS PTHLH VIP
2 response to heat GO:0009408 9.52 CALCA SST
3 regulation of protein localization GO:0032880 9.51 INS VIP
4 positive regulation of cAMP biosynthetic process GO:0030819 9.49 CALCA PTHLH
5 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 9.48 CALCA PTHLH
6 positive regulation of vasodilation GO:0045909 9.46 CALCA INS
7 cell-cell signaling GO:0007267 9.46 CALCA INS PTHLH SST
8 positive regulation of mitotic nuclear division GO:0045840 9.43 IGF2 INS
9 osteoblast development GO:0002076 9.37 MEN1 PTHLH
10 positive regulation of glycogen biosynthetic process GO:0045725 9.32 IGF2 INS
11 positive regulation of insulin receptor signaling pathway GO:0046628 9.26 IGF2 INS
12 negative regulation of vasodilation GO:0045908 8.96 CHGA INS
13 cellular protein metabolic process GO:0044267 8.92 CALCA IGF2 INS MEN1

Molecular functions related to Islet Cell Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.17 CALCA GAST IGF2 INS PTHLH SST
2 insulin receptor binding GO:0005158 9.16 IGF2 INS
3 insulin-like growth factor receptor binding GO:0005159 8.96 IGF2 INS

Sources for Islet Cell Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
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42 MeSH
43 MESH via Orphanet
44 MGI
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48 NDF-RT
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54 OMIM
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60 QIAGEN
65 SNOMED-CT via Orphanet
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68 Tocris
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70 UMLS via Orphanet
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