MCID: ISL001
MIFTS: 48

Islet Cell Tumor

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Islet Cell Tumor

MalaCards integrated aliases for Islet Cell Tumor:

Name: Islet Cell Tumor 38 12 52 14 69
Well Differentiated Pancreatic Endocrine Tumor 69
Malignant Neoplasm of Endocrine Pancreas 69
Malignant Tumor of Endocrine Pancreas 12
Malignant Pancreatic Endocrine Tumor 12
Pancreatic Endocrine Carcinoma 69
Pancreatic Endocrine Neoplasm 12
Endocrine Pancreas Cancer 12
Carcinoma Islet Cell 52
Islet Cell Neoplasm 12
Adenoma, Islet Cell 42
Islet Cell Tumour 12

Classifications:



Summaries for Islet Cell Tumor

Disease Ontology : 12 A pancreatic cancer that is located in the pancreatic islet cells.

MalaCards based summary : Islet Cell Tumor, also known as well differentiated pancreatic endocrine tumor, is related to pheochromocytoma and pancreatic islet cell tumors. An important gene associated with Islet Cell Tumor is SST (Somatostatin), and among its related pathways/superpathways are Signaling by GPCR and G alpha (s) signalling events. The drugs Everolimus and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include pancreas, pancreatic islet and liver, and related phenotypes are cardiovascular system and endocrine/exocrine gland

Related Diseases for Islet Cell Tumor

Diseases related to Islet Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 175)
id Related Disease Score Top Affiliating Genes
1 pheochromocytoma 27.9 CALCA CHGA MEN1 SST VIP
2 pancreatic islet cell tumors 12.2
3 pheochromocytoma-islet cell tumor syndrome 12.0
4 somatostatinoma 11.3
5 mahvash disease 11.1
6 vipoma 11.0
7 pancreatic endocrine carcinoma 10.9
8 pancreatic neuroendocrine tumor 10.9
9 nutritional optic neuropathy 10.7 GAST SST
10 perianal hematoma 10.7 GAST SST
11 pancreatitis 10.7
12 autoimmune enteropathy 10.6 CHGA GAST
13 mental retardation, autosomal recessive 53 10.6 GAST SST
14 bile duct cystadenocarcinoma 10.6 GAST SST
15 renal pelvis carcinoma 10.6 CHGA SST
16 gorlin bushkell jensen syndrome 10.6 CHGA GAST
17 color blindness 10.6 GAST SST
18 rete ovarii cystadenofibroma 10.6 CHGA SST
19 perianal skin paget's disease 10.6 CHGA GAST
20 repetitive stress injuries 10.6 INS SST
21 substance-induced psychosis 10.5 GAST INS
22 protein s deficiency 10.5 INS SST
23 peripheral degeneration of cornea 10.5 INS SST
24 hypoglycemia 10.5
25 diphtheria 10.5 CHGA IGF2
26 breast fibroadenoma 10.5 IGF2 INS
27 hyperphosphatasia with mental retardation syndrome 3 10.5 IGF2 INS
28 epidural abscess 10.5 CHGA IGF2
29 pineal gland cancer 10.5 CHGA PTHLH
30 group b strep disease in newborns 10.4 CHGA INS
31 motility-related diarrhea 10.4 SST VIP
32 paraganglioma 10.4 CHGA SST
33 pigmented villonodular synovitis 10.4 CHGA PTHLH
34 drug psychosis 10.4 SST VIP
35 colon signet ring adenocarcinoma 10.4 CHGA IGF2
36 neuroendocrine tumor of the colon 10.4 CALCA GAST
37 acute myocarditis 10.4 INS SST
38 water-clear cell adenoma 10.4 CALCA SST
39 fibrosarcomatous osteosarcoma 10.4 GAST SST
40 algoneurodystrophy 10.4 IGF2 INS
41 male reproductive system disease 10.4 GAST VIP
42 fetal parvovirus syndrome 10.4 IGF2 INS
43 primary syphilis 10.3 CHGA GAST SST
44 bone giant cell sarcoma 10.3 CHGA GAST SST
45 congenital granular cell tumor 10.3 CALCA CHGA
46 parietal lobe neoplasm 10.3 CALCA CHGA
47 limb-mammary syndrome 10.3 IGF2 INS
48 epilepsy with generalized tonic-clonic seizures 10.3 CHGA GAST SST
49 small cell osteogenic sarcoma 10.3 IGF2 PTHLH
50 tricuspid valve insufficiency 10.3 CALCA CHGA

Graphical network of the top 20 diseases related to Islet Cell Tumor:



Diseases related to Islet Cell Tumor

Symptoms & Phenotypes for Islet Cell Tumor

MGI Mouse Phenotypes related to Islet Cell Tumor:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.88 CHGA IGF2 INS MEN1 PTHLH VIP
2 endocrine/exocrine gland MP:0005379 9.87 CHGA GAST IGF2 INS MEN1 PTHLH
3 homeostasis/metabolism MP:0005376 9.86 SST VIP CHGA GAST IGF2 INS
4 digestive/alimentary MP:0005381 9.85 GAST IGF2 INS MEN1 PTHLH SST
5 immune system MP:0005387 9.7 GAST IGF2 INS MEN1 PTHLH SST
6 mortality/aging MP:0010768 9.56 CHGA GAST IGF2 INS MEN1 PTHLH
7 reproductive system MP:0005389 9.1 CHGA IGF2 INS MEN1 PTHLH VIP

Drugs & Therapeutics for Islet Cell Tumor

Drugs for Islet Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 179)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Everolimus Approved Phase 4,Phase 3,Phase 2,Phase 1 159351-69-6 6442177
2
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
3
Sirolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 53123-88-9 5284616 6436030 46835353
4
Sunitinib Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 341031-54-7, 557795-19-4 5329102
5
Somatostatin Approved Phase 4,Phase 3,Phase 2,Phase 1 38916-34-6, 51110-01-1 53481605
6
Pancrelipase Approved Phase 4,Phase 2,Phase 1 53608-75-6
7
Zinc Approved Phase 4 7440-66-6 32051 23994
8 Pancreatic Polypeptide Investigational Phase 4,Phase 2,Phase 3,Phase 1 59763-91-6
9 Liver Extracts Phase 4,Phase 3,Phase 2,Phase 1
10 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1
11 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Phase 1
12 Antifungal Agents Phase 4,Phase 3,Phase 2,Phase 1
13 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
14 Immunosuppressive Agents Phase 4,Phase 2,Phase 3,Phase 1
15 Angiogenesis Inhibitors Phase 4,Phase 2,Phase 3,Phase 1
16 Angiogenesis Modulating Agents Phase 4,Phase 2,Phase 3,Phase 1
17 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
18 Hormones Phase 4,Phase 3,Phase 2,Phase 1
19 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
20 Hypoglycemic Agents Phase 4,Phase 2,Phase 3,Phase 1
21 pancreatin Phase 4,Phase 2,Phase 1
22 insulin Phase 4,Phase 2
23 Insulin, Globin Zinc Phase 4,Phase 2
24 Fluorodeoxyglucose F18 Phase 4,Phase 2
25
Bevacizumab Approved, Investigational Phase 2, Phase 3 216974-75-3
26
Fluorouracil Approved Phase 2, Phase 3 51-21-8 3385
27
Levoleucovorin Approved Phase 2, Phase 3,Phase 1 68538-85-2
28
Oxaliplatin Approved, Investigational Phase 2, Phase 3,Phase 1 61825-94-3 5310940 9887054 43805 6857599
29 lanreotide Approved Phase 3,Phase 2 108736-35-2
30
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
31
Streptozocin Approved Phase 3,Phase 2 18883-66-4 29327
32
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
33
Exenatide Approved, Investigational Phase 2, Phase 3,Phase 1 141758-74-9 15991534
34
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3,Phase 1 59-30-3 6037
35
leucovorin Approved, Nutraceutical Phase 2, Phase 3, Phase 1 58-05-9 143 6006
36 Antimetabolites Phase 2, Phase 3, Phase 1
37 Antimetabolites, Antineoplastic Phase 2, Phase 3, Phase 1
38 Angiopeptin Phase 3,Phase 2
39 Pharmaceutical Solutions Phase 3
40 Adjuvants, Anesthesia Phase 3
41 Analgesics Phase 3
42 Analgesics, Opioid Phase 3
43 Anesthetics Phase 3
44 Anesthetics, General Phase 3
45 Anesthetics, Intravenous Phase 3
46 Central Nervous System Depressants Phase 3,Phase 2
47 Narcotics Phase 3
48 Peripheral Nervous System Agents Phase 3,Phase 2
49 Dihydroxyphenylalanine Phase 3
50 Dopamine Agents Phase 3

Interventional clinical trials:

(show top 50) (show all 159)

id Name Status NCT ID Phase Drugs
1 Disease-Specific Questionnaire in Assessing Quality of Life in Patients With Gastrointestinal-Related Neuroendocrine Tumors Unknown status NCT00454376 Phase 4
2 Phase IV Study of the Safety and Efficacy of Everolimus in Adult Patients With Progressive pNET in China Recruiting NCT02842749 Phase 4 everolimus
3 Nonfunctional Pancreatic NET and PET Imaging Recruiting NCT02621541 Phase 4
4 Clinical Effectiveness of Serum Chromogranin A Levels on Diagnostic of Pancreatic Neuroendocrine Tumors Active, not recruiting NCT02759718 Phase 4
5 A Study Of The Efficacy And Safety Of Sunitinib In Patients With Advanced Well-Differentiated Pancreatic Neuroendocrine Tumors Active, not recruiting NCT01525550 Phase 4 sunitinib
6 Pasireotide Treatment for Neuroendocrine Tumor Withdrawn NCT02779257 Phase 4 Pasireotide;Diazoxide
7 Combination Chemotherapy and Bevacizumab in Treating Patients With Advanced Neuroendocrine Tumors Unknown status NCT00227617 Phase 2, Phase 3 5-fluorouracil;leucovorin;oxaliplatin
8 Study of Lanreotide Autogel 120 mg in Patients With Non-functioning Entero- Pancreatic Endocrine Tumour Completed NCT00842348 Phase 3 lanreotide (Autogel formulation)
9 Study of Lanreotide Autogel in Non-functioning Entero-pancreatic Endocrine Tumours Completed NCT00353496 Phase 3 lanreotide (Autogel formulation);Placebo
10 Efficacy and Safety of Everolimus (RAD001) Compared to Placebo in Patients With Advanced Neuroendocrine Tumors Completed NCT00510068 Phase 3 Everolimus;Everolimus Placebo
11 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
12 Safety and Efficacy Study of In-111 Pentetreotide to Treat Neuroendocrine Tumors Completed NCT00442533 Phase 2, Phase 3 Indium-111 pentetreotide
13 A Study Evaluating Lanreotide as Maintenance Therapy in Patients With Non-Resectable Duodeno-Pancreatic Neuroendocrine Tumors (REMINET) Recruiting NCT02288377 Phase 2, Phase 3 lanreotide;Placebo
14 Phase III Study of Sulfatinib in Treating Advanced Pancreatic Neuroendocrine Tumors Recruiting NCT02589821 Phase 3 Sulfatinib
15 Efficacy and Safety of Everolimus and (STZ-5FU) Given One Upfront the Other Upon Progression in Advanced pNET Recruiting NCT02246127 Phase 3 Drug: Everolimus;STZ-5FU
16 Efficacy and Safety of Radiofrequency Ablation in Pancreatic Neuroendocrine and Cystic Tumor Recruiting NCT02330497 Phase 3
17 18F-DOPA PET Imaging: an Evaluation of Biodistribution and Safety Recruiting NCT03042416 Phase 3 18F-DOPA
18 New Imaging Procedure for the Localisation of Insulinoma and Transplanted Islet Cells Recruiting NCT02127541 Phase 2, Phase 3
19 Non-functioning Pancreatic Neuroendocrine Tumors in MEN1: Somatostatin Analogs Versus NO Treatment Not yet recruiting NCT02705651 Phase 3 Somatostatin-Analog
20 A Study Of Sunitinib Compared To Placebo For Patients With Advanced Pancreatic Islet Cell Tumors Terminated NCT00428597 Phase 3 sunitinib malate;Placebo
21 68-Ga-labeled Octreotide Analogues PET in Duodenal-pancreatic Neuroendocrine Tumours Unknown status NCT01673906 Phase 2 Diagnostic work up
22 Activity and Safety of Everolimus+Octreotide LAR+Metformin in Advanced Pancreatic Well-differentiated NETs Unknown status NCT02294006 Phase 2 Everolimus plus Octreotide LAR plus Metformin
23 Single Arm Trial With Combination of Everolimus and Letrozole in Treatment of Platinum Resistant Relapse or Refractory or Persistent Ovarian Cancer/Endometrial Cancer Unknown status NCT02188550 Phase 2 everolimus and letrozole
24 Recombinant Anti-tumor and Anti-virus Protein for Injection to Treat Advanced Neuroendocrine Tumors Unknown status NCT02455596 Phase 2 Recombinant anti-tumor and anti-virus protein for injection (Novaferon)
25 177Lutetium-DOTA-Octreotate Therapy in Somatostatin Receptor-Expressing Neuroendocrine Neoplasms Unknown status NCT01237457 Phase 2 177Lu-DOTATATE
26 BEZ235 Phase II Trial in Patients With Advanced Pancreatic Neuroendocrine Tumors (pNET) After Failure of mTOR Inhibitor Therapy. Completed NCT01658436 Phase 2 BEZ235 (Stage 1)
27 Chemotherapy Plus Endostatin in Advanced Pancreatic Neuroendocrine Tumor Completed NCT01845675 Phase 2 temozolomide or dacarbazine-based chemotherapy, endostatin
28 Efficacy And Safety Of Sunitinib In Patients With Advanced Well-Differentiated Pancreatic Neuroendocrine Tumors Completed NCT01121562 Phase 2 Sunitinib
29 Combination Chemotherapy in Patients With Zollinger-Ellison Syndrome and Tumors of the Pancreas Completed NCT00001165 Phase 2 combined chemotherapy with streptozotocin, 5-fluorouracil, and doxorubicin
30 Combination Chemotherapy as First-Line Therapy in Treating Patients With Locally Advanced or Metastatic Neuroendocrine Tumors of the Duodenum or Pancreas That Cannot Be Removed By Surgery Completed NCT00416767 Phase 2 fluorouracil;irinotecan hydrochloride;leucovorin calcium
31 Safety/Efficacy of Everolimus in Adults With Advanced Pancreatic Neuroendocrine Cancer Not Responsive to Chemotherapy Completed NCT00363051 Phase 2 Everolimus 10 mg;Octreotide Depot
32 Interferon and Octreotide to Treat Zollinger-Ellison Syndrome and Advanced Non-B Islet Cell Cancer Completed NCT00001228 Phase 2 Interferon
33 Capecitabine and Streptozocin With or Without Cisplatin in Treating Patients With Unresectable or Metastatic Neuroendocrine Tumors Completed NCT00602082 Phase 2 capecitabine;cisplatin;streptozocin
34 A Study of IMC-A12 in Islet Cell Cancer Completed NCT00781911 Phase 2 depot octreotide
35 Combination of Lanreotide Autogel 120mg and Temozolomide in Progressive GEP-NET Completed NCT02231762 Phase 2 Lanreotide Autogel 120 mg;Temozolomide (TMZ)
36 PS-341 in Treating Patients With Metastatic Neuroendocrine Tumors Completed NCT00017199 Phase 2 bortezomib
37 Phase II Study of Sunitinib Malate Following Hepatic Artery Embolization Completed NCT00434109 Phase 2 Sunitinib malate
38 AMG 706 and Octreotide in Treating Patients With Low-Grade Neuroendocrine Tumors Completed NCT00427349 Phase 2 AMG 706;octreotide
39 RAD001 Plus Octreotide Depot in Metastatic or Unresectable Low Grade Neuroendocrine Carcinoma Completed NCT00113360 Phase 2 RAD001;Octreotide Depot
40 Thalidomide in Treating Patients With Metastatic Neuroendocrine Tumors Completed NCT00027638 Phase 2 thalidomide
41 68Ga-OPS202 Study for Diagnostic Imaging of GEP NET Completed NCT02162446 Phase 1, Phase 2 68Ga-OPS202
42 Pazopanib as Single Agent in Advanced NETs Completed NCT01280201 Phase 2 Pazopanib
43 The Use of Oral Omeprazole and Intravenous Pantoprazole in Patients With Hypersecretion of Gastric Acid Completed NCT00001191 Phase 2 Pantoprazole;Omeprazole
44 Study of MK-2206 in Patients With Metastatic Neuroendocrine Tumors (NET) Completed NCT01169649 Phase 2 MK-2206
45 KPT-330 to Treat Poorly Differentiated Lung and Gastroenteropancreatic Tumors Completed NCT02250885 Phase 2 Selinexor
46 Isolated Hepatic Perfusion With Melphalan in Treating Patients With Primary Unresectable Liver Cancer or Liver Metastases Completed NCT00019786 Phase 2 isolated perfusion;melphalan
47 Temsirolimus in Treating Patients With Metastatic Neuroendocrine Carcinoma Completed NCT00093782 Phase 2 temsirolimus
48 Sorafenib Tosylate in Treating Patients With Progressive Metastatic Neuroendocrine Tumors Completed NCT00131911 Phase 2 sorafenib tosylate
49 Temsirolimus and Bevacizumab in Treating Patients With Advanced Endometrial, Ovarian, Liver, Carcinoid, or Islet Cell Cancer Completed NCT01010126 Phase 2 Temsirolimus
50 Gefitinib in Treating Patients With Progressive Metastatic Neuroendocrine Tumors Completed NCT00075439 Phase 2 gefitinib

Search NIH Clinical Center for Islet Cell Tumor

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: adenoma, islet cell

Genetic Tests for Islet Cell Tumor

Anatomical Context for Islet Cell Tumor

MalaCards organs/tissues related to Islet Cell Tumor:

39
Pancreas, Pancreatic Islet, Liver, Breast, Lung, Endothelial, Lymph Node

Publications for Islet Cell Tumor

Articles related to Islet Cell Tumor:

(show top 50) (show all 351)
id Title Authors Year
1
A Case of Non-Islet Cell Tumor Hypoglycemia (NICTH) Associated with Gastrointestinal Stromal Tumor (GIST). ( 28900071 )
2017
2
Characterization of pancreatic islet cell tumors and renal tumors induced by a combined treatment of streptozotocin and nicotinamide in male SD rats. ( 28390812 )
2017
3
Levels of glucose-regulatory hormones in patients with non-islet cell tumor hypoglycemia: including a review of the literature. ( 28529277 )
2017
4
Non-islet cell tumor hypoglycemia caused by intrathoracic solitary fibrous tumor: a case report. ( 27061182 )
2016
5
Non-islet cell tumor hypoglycemia caused by a big insulin-like growth factor II- producing hepatocellular carcinoma:an autopsy case report. ( 27916774 )
2016
6
Fatal hepatitis B reactivation in a patient with islet cell tumor on octreotide and sirolimus. ( 26487953 )
2015
7
Non-Islet Cell Tumor Hypoglycemia Is Caused by Big IGF-II in a Patient with a Carcinosarcoma of the Uterus. ( 26666605 )
2015
8
The Transformation of a Nonfunctioning Islet Cell Tumor of the Pancreas into a Proinsulinoma under Conditions of Lung Metastasis. ( 25832942 )
2015
9
Multiple hepatocellular adenomas presenting in a male 8 years post-pancreaticoduodenectomy for islet cell tumor of the pancreas. ( 25810673 )
2015
10
A 94-year-old man with recurrent hypoglycemia caused by non-islet cell tumor hypoglycemia (NICTH). ( 25780362 )
2014
11
Characterization of a pancreatic islet cell tumor in a polar bear (Ursus maritimus). ( 25273481 )
2014
12
Nonfunctional islet cell tumor of the pancreas in a patient with tuberous sclerosis: a case report with literature review. ( 24678435 )
2014
13
Bioactive insulin-like growth factors as a possible molecular target for non-islet cell tumor hypoglycemia. ( 25535894 )
2014
14
Nesidioblastosis and Pancreatic Non-functioning Islet Cell Tumor in an Adult with Type 2 Diabetes Mellitus. ( 24255640 )
2013
15
GPR119 expression in normal human tissues and islet cell tumors: evidence for its islet-gastrointestinal distribution, expression in pancreatic beta and alpha cells, and involvement in islet function. ( 22883930 )
2013
16
Non-islet cell tumor hypoglycemia associated with recurrent carcinosarcoma of the ovary. ( 23512392 )
2013
17
Surgical treatment of pancreatic islet cell tumor: report of 44 cases. ( 24719954 )
2013
18
Metastatic Insulinoma Following Resection of Nonsecreting Pancreatic Islet Cell Tumor: A Case Report and Review of the Literature. ( 26425568 )
2013
19
Non-islet cell tumor-induced hypoglycemia: a report of five cases and brief review of the literature. ( 24616774 )
2013
20
Gastric neuroendocrine carcinoma with non-islet cell tumor hypoglycemia associated with enhanced production of insulin-like growth factor II. ( 23545670 )
2013
21
Management of Non-Islet-Cell Tumor Hypoglycemia: A Clinical Review. ( 24423303 )
2013
22
Non-Islet Cell Tumor-Induced Hypoglycemia Associated with Macronodular Pulmonary Metastases from Poorly Differentiated Thyroid Carcinoma. ( 23697382 )
2013
23
Severe hypoglycemia with "Big"-IGF-2 oversecretion by a giant phyllode tumor of the breast: a rare case of non-islet cell tumor-induced hypoglycemia (NICTH). ( 22867750 )
2012
24
Gastrointestinal stromal tumor of the pelvic soft tissue presenting with symptomatic hypoglycemia: A case report and brief review of current literature of non-islet cell tumor-induced hypoglycemia. ( 24371628 )
2012
25
Non-islet cell tumor hypoglycemia at the second recurrence of malignant solitary fibrous tumor in the retroperitoneum and pelvis: a case report. ( 22949904 )
2012
26
Sorafenib inhibits tumor growth and improves survival in a transgenic mouse model of pancreatic islet cell tumors. ( 23346016 )
2012
27
Recurrent solitary fibrous tumor of the pleura with malignant transformation and non-islet cell tumor-induced hypoglycemia due to paraneoplastic overexpression and secretion of high-molecular-weight insulin-like growth Factor II. ( 23207122 )
2012
28
Retrospective Review of Cross Sectional Imaging Findings of Pancreatic Non-functional Islet Cell Tumor (NFICT) and its Hepatic Metastases. ( 22043378 )
2011
29
Non-islet cell tumor hypoglycemia associated with uterine leiomyomata. ( 21550955 )
2011
30
Pancreatic and peri-pancreatic lesions mimic pancreatic islet cell tumor in multidetector computed tomography. ( 21740785 )
2011
31
Diabetic ketoacidosis with concurrent pancreatitis, pancreatic I^ islet cell tumor, and adrenal disease in an obese ferret (Mustela putorius furo). ( 21838985 )
2011
32
Diffusion weighted MR imaging of pancreatic islet cell tumors. ( 19264435 )
2010
33
Metastatic pancreatic polypeptide-secreting islet cell tumor in a dog. ( 20698942 )
2010
34
Systematic comparison of sporadic and syndromic pancreatic islet cell tumors. ( 20660572 )
2010
35
A case of gastric cancer with non-islet cell tumor hypoglycemia detected by insulin-like growth factor II. ( 20618739 )
2010
36
Hepatic abscess after yttrium-90 radioembolization for islet-cell tumor hepatic metastasis. ( 19688373 )
2010
37
Successful control of intractable hypoglycemia using rapamycin in an 86-year-old man with a pancreatic insulin-secreting islet cell tumor and metastases. ( 19567519 )
2009
38
Non-islet cell tumor hypoglycemia. ( 19345293 )
2009
39
Insulinoma with six islet cell tumors associated with severe hypoglycemia. ( 19525595 )
2009
40
Homozygous P86S mutation of the human glucagon receptor is associated with hyperglucagonemia, alpha cell hyperplasia, and islet cell tumor. ( 19657311 )
2009
41
Pancreatic islet cell tumor secreting insulin-like growth factor type-II in a dog. ( 19780935 )
2009
42
Nesidioblastosis and hyperplasia of alpha cells, microglucagonoma, and nonfunctioning islet cell tumor of the pancreas: review of the literature. ( 18437091 )
2008
43
Islet cell tumor of the pancreas: increasing diagnosis after instituting ultrasonography-guided fine needle aspiration. ( 18323274 )
2008
44
Spectrum of functioning islet cell tumor on multislice computed tomography: experience on 70 patients. ( 18437902 )
2008
45
Hypoglycemia associated with the production of insulin-like growth factor II in a pancreatic islet cell tumor: a case report. ( 18490836 )
2008
46
Non-islet-cell tumor hypoglycemia and lactic acidosis in a child with congenital HIV and Burkitt's lymphoma. ( 18825882 )
2008
47
Successful treatment of non-islet cell tumor hypoglycemia in hepatocellular carcinoma with doxorubicin. ( 18278497 )
2008
48
Spontaneous pancreatic islet cell tumor in a black and white colobus monkey (Colobus guereza kikuyuensis). ( 18269522 )
2008
49
Generation and characterization of islet cell tumor in pTet-on/pTRE-SV40Tag double-transgenic mice model. ( 17697978 )
2007
50
Solitary fibrous tumor associated with non-islet cell tumor hypoglycemia. ( 17588442 )
2007

Variations for Islet Cell Tumor

Expression for Islet Cell Tumor

Search GEO for disease gene expression data for Islet Cell Tumor.

Pathways for Islet Cell Tumor

Pathways related to Islet Cell Tumor according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.45 CALCA GAST IGF2 INS MEN1 PTHLH
2 11.3 CALCA PTHLH VIP
3 10.98 IGF2 INS
4 9.47 GAST VIP

GO Terms for Islet Cell Tumor

Cellular components related to Islet Cell Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 CALCA CHGA GAST IGF2 INS PTHLH
2 extracellular region GO:0005576 9.23 CALCA CHGA GAST IGF2 INS PTHLH

Biological processes related to Islet Cell Tumor according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.71 IGF2 INS PTHLH VIP
2 regulation of protein localization GO:0032880 9.51 INS VIP
3 response to heat GO:0009408 9.49 CALCA SST
4 positive regulation of cAMP biosynthetic process GO:0030819 9.48 CALCA PTHLH
5 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 9.46 CALCA PTHLH
6 positive regulation of mitotic nuclear division GO:0045840 9.43 IGF2 INS
7 osteoblast development GO:0002076 9.37 MEN1 PTHLH
8 positive regulation of glycogen biosynthetic process GO:0045725 9.32 IGF2 INS
9 cell-cell signaling GO:0007267 9.26 CALCA INS PTHLH SST
10 positive regulation of insulin receptor signaling pathway GO:0046628 9.16 IGF2 INS
11 positive regulation of cAMP metabolic process GO:0030816 8.96 CHGA
12 cellular protein metabolic process GO:0044267 8.92 CALCA IGF2 INS MEN1

Molecular functions related to Islet Cell Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.17 CALCA GAST IGF2 INS PTHLH SST
2 insulin receptor binding GO:0005158 9.16 IGF2 INS
3 insulin-like growth factor receptor binding GO:0005159 8.96 IGF2 INS

Sources for Islet Cell Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
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48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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