MCID: ISL001
MIFTS: 51

Islet Cell Tumor malady

Summaries for Islet Cell Tumor

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33MalaCards
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MalaCards: Islet Cell Tumor, also known as benign islet cell tumor, is related to pancreatic islet cell tumors and hypoglycemia. An important gene associated with Islet Cell Tumor is CHGA (chromogranin A (parathyroid secretory protein 1)), and among its related pathways are Calcitonin-like ligand receptors and Inhibition of TSC complex formation by PKB. The compounds estrogen and forskolin have been mentioned in the context of this disorder. Related mouse phenotypes are adipose tissue and tumorigenesis.

Aliases & Classifications for Islet Cell Tumor

Sources:
8Disease Ontology, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH
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Aliases & Descriptions:

islet cell tumor 8 61
benign islet cell tumor 8 61
pancreatic endocrine neoplasm 8
tumor of endocrine pancreas 8
islet cell tumour, benign 8
benign islet cell tumour 8
islet cell neoplasm 8
islet cell tumour 8


Related Diseases for Islet Cell Tumor

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Islet Cell Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 219)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatic islet cell tumors31.5PTHLH, RET, PCSK1, SST, IAPP, CHGA
2hypoglycemia31.4INS, IGF2, SST, IAPP, CHGA, GHRH
3hyperinsulinism30.7INS, IGF2, SST
4zollinger-ellison syndrome30.6SST, CHGA, GHRH, MEN1, GAST
5multiple endocrine neoplasia30.6RET, CHGA, MEN1, GAST, CALCA, VIP
6hypercalcemia30.6PTHLH, IAPP, CHGA, MEN1, GAST, CALCA
7cushing's syndrome30.6RET, SST, CHGA, SYP, GHRH, MEN1
8acromegaly30.6INS, IGF2, SST, GHRH, GHRHR, MEN1
9pheochromocytoma30.6RET, PCSK1, SST, NTS, IAPP, CHGA
10adenoma30.5TSC1, INS, RET, PCSK1, POU1F1, IGF2
11gastric ulcer30.5GAST
12hypokalemia30.5INS, VIP
13somatostatinoma30.5SST, CHGA, GHRH, GAST, CALCA, VIP
14glucagonoma30.5PCSK1, SST, CHGA, GHRH, MEN1, GAST
15insulinoma30.5INS, PCSK1, IGF2, SST, NTS, IAPP
16duodenal ulcer30.3INS, SST, GAST
17thyroid cancer30.3RET, SST, CHGA, CALCA
18neurofibromatosis30.2TSC2, TSC1, RET, SST, MEN1
19cholelithiasis30.1SST
20acute pancreatitis30.1SST, IAPP
21diabetic ketoacidosis30.1INS
22pancreatic cholera30.1SST, VIP
23acinar cell carcinoma30.1CHGA, GAST
24pancreatic endocrine carcinoma30.1PTHLH, SST, GAST
25tuberous sclerosis30.1TSC2, TSC1, SYP
26serotonin syndrome30.1SST, CHGA, GHRH, MEN1, GAST
27cholera30.1INS, NTS, CALCA, VIP
28neuroendocrine carcinoma30.1SST, CHGA, SYP, MEN1, GAST, CALCA
29gastrinoma30.1SST, IAPP, CHGA, SYP, MEN1, GAST
30vipoma30.1SST, NTS, CHGA, GHRH, MEN1, GAST
31pituitary tumors30.1PCSK1, POU1F1, SST, CHGA, GHRH, GHRHR
32carcinoid syndrome30.1RET, PCSK1, SST, NTS, IAPP, CHGA
33adenocarcinoma30.1TSC2, TSC1, PTHLH, POU1F1, SST, NTS
34pheochromocytoma-islet cell tumor syndrome10.5
35somatostatin analog10.4
36amyloid tumor10.3
37pancreatic endocrine tumors10.3
38solitary fibrous tumor10.3
39portal hypertension10.3
40gastrointestinal stromal tumor10.3
41mahvash disease10.3
42pancreatic adenoma10.1
43recurrent acute pancreatitis10.1
44pancreatic steatorrhea10.1
45steatorrhea10.1
46cystadenoma10.1
47pancreatic somatostatinoma10.1
48pancreatic gastrinoma10.1
49microcystic adenoma10.1
50extramedullary plasmacytoma10.1

Graphical network of the top 20 diseases related to Islet Cell Tumor:



Diseases related to islet cell tumor

Clinical Features for Islet Cell Tumor

Drugs & Therapeutics for Islet Cell Tumor

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Islet Cell Tumor

Drug clinical trials:

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Search NIH Clinical Center for Islet Cell Tumor

Search CenterWatch for Islet Cell Tumor

Genetic Tests for Islet Cell Tumor

Anatomical Context for Islet Cell Tumor

Animal Models for Islet Cell Tumor or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Islet Cell Tumor:

37 (show all 18)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537510.1GCGR, NTS, PCSK1
2MP:00020069.5CALCA, GAST, MEN1, RET, TSC1, TSC2
3MP:00053799.5GCGR, GAST, MEN1, GHRHR, GHRH, POU1F1
4MP:00053909.4CALCA, GHRHR, IAPP, IGF2, INS, PTHLH
5MP:00107719.4CALCA, GHRHR, IGF2, INS, TSC1, TSC2
6MP:00053679.4CALCA, CHGA, IGF2, RET, INS, PTHLH
7MP:00053819.4GAST, MEN1, SST, IGF2, PCSK1, RET
8MP:00053809.3MEN1, IGF2, RET, INS, TSC1, TSC2
9MP:00028739.3VIP, GCGR, CALCA, SYP, SST, RET
10MP:00053709.2MEN1, GHRH, IGF2, INS, TSC1, TSC2
11MP:00053859.0VIP, CALCA, MEN1, CHGA, IGF2, PCSK1
12MP:00053868.9SST, NTS, GHRHR, CALCA, VIP, IGF2
13MP:00053878.8VIP, GAST, MEN1, GHRHR, GHRH, IAPP
14MP:00053898.6CHGA, GHRH, GHRHR, MEN1, GCGR, VIP
15MP:00036318.6NTS, SYP, GHRH, GHRHR, MEN1, CALCA
16MP:00107688.5CHGA, MEN1, GAST, CALCA, GCGR, VIP
17MP:00053788.3NTS, IAPP, CHGA, GHRH, GHRHR, MEN1
18MP:00053767.9TSC2, CHGA, GHRH, GHRHR, MEN1, GAST

Publications for Islet Cell Tumor

Sources:
51PubMed
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Articles related to Islet Cell Tumor:

(show top 50)    (show all 358)
idTitleAuthorsYear
1
GPR119 expression in normal human tissues and islet cell tumors: evidence for its islet-gastrointestinal distribution, expression in pancreatic beta and alpha cells, and involvement in islet function. (22883930)
2013
2
Recurrent solitary fibrous tumor of the pleura with malignant transformation and non-islet cell tumor-induced hypoglycemia due to paraneoplastic overexpression and secretion of high-molecular-weight insulin-like growth Factor II. (23207122)
2012
3
Diffusion weighted MR imaging of pancreatic islet cell tumors. (19264435)
2010
4
A case of gastric cancer with non-islet cell tumor hypoglycemia detected by insulin-like growth factor II. (20618739)
2010
5
KIT is an independent prognostic marker for pancreatic endocrine tumors: a finding derived from analysis of islet cell differentiation markers. (19574886)
2009
6
Spontaneous pancreatic islet cell tumor in a black and white colobus monkey (Colobus guereza kikuyuensis). (18269522)
2008
7
Neuroendocrine tumors. Molecular targeted therapy for carcinoid and islet-cell carcinoma. (17382271)
2007
8
Generation and characterization of islet cell tumor in pTet-on/pTRE-SV40Tag double-transgenic mice model. (17697978)
2007
9
Differential diagnosis of non-functional islet cell tumor and pancreatic carcinoma with sonography. (17412543)
2007
10
Islet cell tumor arising from a heterotopic pancreas in the duodenal wall with ulceration. (14738869)
2004
11
Natural history of a patient with malignant nonfunctioning islet cell tumor associated with unresectable multiple liver metastases. (15354423)
2004
12
The antimetastatic role of thrombomodulin expression in islet cell-derived tumors and its diagnostic value. (15448005)
2004
13
Growth hormone therapy for non-islet cell tumor hypoglycemia. (12208393)
2002
14
Expression of ghrelin and of the GH secretagogue receptor by pancreatic islet cells and related endocrine tumors. (11889202)
2002
15
Malignant islet cell tumor with sarcomatous differentiation. (11706083)
2001
16
Functional pancreatic islet cell tumors with liver metastasis: the role of cytoreductive surgery and transcatheter arterial chemoembolization: a report of five cases. (9884450)
1998
17
Immunohistochemistry of pancreatic islet cell tumors in the ferret (Mustela putorius furo). (9381649)
1997
18
Functioning islet cell tumor of the pancreas. Localization with dynamic spiral CT. (9059417)
1997
19
Dissociation between the effects of somatostatin (SS) and octapeptide SS-analogs on hormone release in a small subgroup of pituitary- and islet cell tumors. (9284735)
1997
20
Mechanism of gastric acid hypersecretion in patients with islet cell tumor without hypergastrinemia: studies in rats. (9322507)
1997
21
Gelatinases and inhibitors of gelatinases in pancreatic islets and islet cell tumors. (9021726)
1997
22
Immunohistochemical studies of nonsecreting pancreatic islet cell tumors secreting many hormones]. (9388878)
1996
23
Minute malignant islet cell tumor of the pancreas: report of a case. (7640475)
1995
24
Characterization of insulin-like growth factor II (IGF-II) and IGF binding proteins in patients with non-islet-cell tumor hypoglycemia. (7524924)
1993
25
Surgical experience with pancreatic islet-cell tumors. (8105769)
1993
26
Use of isotope-labeled somatostatin analogs for visualization of islet cell tumors. (8395748)
1993
27
The dissociation of tumor-induced weight loss from hypoglycemia in a transplantable pluripotent rat islet tumor results in the segregation of stable alpha- and beta-cell tumor phenotypes. (8404649)
1993
28
Non-functioning pancreatic islet cell tumor presenting with gastrointestinal hemorrhage. (1655645)
1991
29
A glucagon-secreting pancreatic alpha islet cell tumor presenting as spinal cord compression. (3039255)
1987
30
Cystic islet cell tumor of the pancreas. (3014225)
1986
31
Somatostatinoma--the most recently described pancreatic islet cell tumor. (2859702)
1985
32
Malignant islet-cell tumor of the pancreas diagnosed by fine needle aspiration biopsy. A case report. (2992200)
1985
33
Metastatic islet cell tumor in von Hippel-Lindau disease. (6331159)
1984
34
Stimulation of insulin release by glucose in a transplantable rat islet cell tumor. (6183110)
1982
35
Rupture of a giant non-functioning pancreatic islet cell tumor following minimal trauma. (6258461)
1981
36
Serially transplantable chemically induced rat islet cell tumor. (6250800)
1980
37
Continuous, clonal, insulin- and somatostatin-secreting cell lines established from a transplantable rat islet cell tumor. (6106192)
1980
38
Ductal adenocarcinoma or islet-cell tumor? (205785)
1978
39
Localization of 99m Tc-pyrophosphate in an islet cell tumor of the pancreas. (213222)
1978
40
Islet cell tumor in a neonate: diagnosis by selective angiography and histological findings. (208049)
1978
41
Recent advances in management of functioning islet cell tumor. (4335281)
1972
42
Alterations of blood sugar and plasma insulin after cryosurgery of functioning islet-cell tumor. (4345377)
1972
43
Cushing's syndrome and avascular necrosis of bone associated with carcinoid-islet cell tumor of the pancreas. (4342410)
1972
44
An ultrastructural study of the islet cell tumor of the golden hamster. (4331701)
1971
45
Adipose tissue lipolysis in golden hamsters with chronic hypoglycemia and hyperinsulinemia due to a transplantable islet cell tumor. (4329446)
1970
46
Giant nonfunctioning islet cell tumor. Survival after pancreaticoduodenectomy. (4296368)
1968
47
Functioning metastases from an islet cell tumor of the pancreas. (4289479)
1966
48
Pancreatoduodenectomy for islet-cell tumor of the pancreas in infancy and childhood. Case report with five-year survival. (4287771)
1966
49
The syndrome of refractory watery diarrhea and hypokalemia in patients with a non-insulin-secreting islet cell tumor. A further case study and review of the literature. (14476287)
1962
50
Islet cell tumor of the pancreas. (13564089)
1958

Genetic Variations for Islet Cell Tumor

Expression for genes affiliated with Islet Cell Tumor

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Islet Cell Tumor

Search GEO for disease gene expression data for Islet Cell Tumor.

Pathways for genes affiliated with Islet Cell Tumor

Sources:
54Reactome, 12EMD Millipore, 52QIAGEN, 30KEGG
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Pathways related to Islet Cell Tumor according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2IAPP, CALCA
210.1TSC2, TSC1
310.1PCSK1, IAPP, CHGA
4
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10.0CALCA, IAPP, INS
510.0TSC2, TSC1, IGF2
6
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10.0TSC2, TSC1, IGF2
7
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9.8IGF2, INS, TSC1, TSC2
8
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9.7GHRH, IGF2, INS, TSC1, TSC2
9
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9.7VIP, GCGR, CALCA, GHRHR, GHRH, IAPP
10
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9.3GCGR, CALCA, GHRHR, GHRH, IAPP, NTS
11
Hide members
8.2TSC2, VIP, GCGR, CALCA, GAST, MEN1

Compounds for genes affiliated with Islet Cell Tumor

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 29IUPHAR, 24HMDB, 60Tocris Bioscience, 2BitterDB
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Compounds related to Islet Cell Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 151)
idCompoundScoreTop Affiliating Genes
1estrogen4510.7PCSK1
2forskolin45 50 1112.4POU1F1, GHRH, GHRHR, CALCA
3111in-pentetreotide4510.2CALCA, SYP, CHGA, SST
4atropine45 29 1112.2NTS, GHRH, GAST, CALCA
5glutamate4510.1POU1F1, GAST, GHRHR, GHRH, NTS
6i-app4510.1PCSK1, INS, IAPP, GAST, CALCA
7mibg4510.1SST, CALCA, VIP, CHGA
8dopamine45 29 11 2413.1GHRH, NTS, IAPP, CHGA, GAST, VIP
9bromocriptine29 45 1112.0IGF2, GHRH, POU1F1, SST, VIP
10gnrh4510.0CHGA, NTS, GHRH, GAST, VIP, PCSK1
11clonidine45 29 1112.0CALCA, NTS, GHRH, CHGA, SST
12propranolol45 29 50 11 2414.0CALCA, GAST, CHGA, SST, VIP, GHRH
13streptozotocin4510.0SYP, CHGA, IAPP, SST, INS
14calcium gluconate4510.0INS, GAST, CALCA
15dbc-amp459.9GHRH, SYP, NTS, IGF2, VIP, PTHLH
16oxyntomodulin45 6010.9SST, PCSK1, VIP, GCGR, GAST, CHGA
17catecholamine459.9VIP, IAPP, RET, SYP, CHGA, NTS
18nifedipine45 50 29 1112.8GHRH, CHGA, PTHLH, NTS, SST, VIP
195-hydroxytryptamine459.8SYP, NTS, VIP, SST, GAST, CALCA
20dexamethasone45 50 29 1112.8GHRHR, VIP, GHRH, IAPP, NTS, IGF2
21hydrocortisone45 2 60 1112.8CALCA, GAST, PTHLH, SST, IGF2, INS
22isoproterenol45 1110.8PTHLH, SST, NTS, GAST, CHGA, CALCA
23ibmx45 29 6011.7IGF2, VIP, CALCA, SST, PCSK1, INS
24norepinephrine45 11 2411.7VIP, CALCA, GAST, GHRH, SYP, CHGA
25c-peptide459.7NTS, SST, IGF2, PCSK1, INS, IAPP
26vitamin d459.6PTHLH, POU1F1, GHRH, MEN1, GAST, CHGA
27ribonucleic acid459.6RET, IGF2, GHRHR, GHRH, CHGA, PTHLH
285-hydroxyindoleacetic acid45 2410.6CHGA, SST, VIP, GAST
29lactate459.6PTHLH, VIP, CHGA, SST, CALCA, INS
30acth459.6IGF2, VIP, GAST, GHRH, SYP, CHGA
31acetylcholine45 50 29 11 2413.6GAST, SYP, CHGA, NTS, CALCA, SST
32thyroxine45 2410.5INS, IGF2, GAST, SST, VIP, NTS
33epinephrine45 11 2411.5CHGA, GAST, IAPP, GCGR, VIP, CALCA
34creatinine459.5PTHLH, GAST, SYP, CHGA, IAPP, IGF2
35thymidine45 2410.5PTHLH, POU1F1, IGF2, NTS, IAPP, MEN1
36octreotide45 60 29 1112.5SST, PTHLH, INS, VIP, CALCA, GAST
37paraffin459.5NTS, TSC1, PTHLH, TSC2, RET, IGF2
38histamine45 29 2411.4GCGR, VIP, CALCA, GAST, SYP, SST
39glycogen45 2410.4IGF2, TSC1, INS, PTHLH, IAPP, CHGA
40serine459.4GHRH, TSC1, RET, PCSK1, NTS, IAPP
41glucose459.3TSC2, TSC1, PCSK1, IGF2, NTS, GHRH
42cyclic amp45 2410.1GHRH, NTS, GCGR, CALCA, GHRHR, SYP
43vegf459.0CALCA, PTHLH, GAST, SYP, TSC2, TSC1
44alanine459.0VIP, GAST, TSC1, NTS, IGF2, PTHLH
45adenylate458.9GAST, CALCA, GCGR, VIP, GHRHR, GHRH
46arginine458.9POU1F1, IGF2, SST, NTS, IAPP, CHGA
47lipid458.8PCSK1, RET, PTHLH, TSC2, IAPP, GHRH
48testosterone45 60 11 2411.8INS, PTHLH, TSC2, RET, IGF2, GHRH
49tyrosine458.7TSC2, TSC1, PTHLH, INS, RET, NTS
50calcium45 50 11 2411.6RET, GAST, CALCA, CHGA, VIP, GCGR

GO Terms for genes affiliated with Islet Cell Tumor

Sources:
16Gene Ontology
See all sources

Cellular components related to Islet Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:03477410.1INS, PCSK1
2TSC1-TSC2 complexGO:0335969.8TSC2, TSC1
3neuronal cell bodyGO:0430259.7VIP, CALCA, IAPP, SST, TSC2
4extracellular spaceGO:0056159.3CALCA, GHRH, IAPP, SST, IGF2, PCSK1
5extracellular regionGO:0055769.0PTHLH, VIP, CALCA, GAST, GHRH, CHGA

Biological processes related to Islet Cell Tumor according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1somatotropin secreting cell developmentGO:06013310.5GHRHR, POU1F1
2positive regulation of growth hormone secretionGO:06012410.4GHRHR, GHRH
3growth hormone secretionGO:03025210.4GHRHR, GHRH
4negative regulation of bone resorptionGO:04577910.3IAPP, CALCA
5positive regulation of insulin receptor signaling pathwayGO:04662810.3INS, IGF2
6positive regulation of multicellular organism growthGO:04001810.3POU1F1, GHRH, GHRHR
7positive regulation of vasodilationGO:04590910.3INS, CALCA, VIP
8regulation of blood pressureGO:00821710.3GCGR, CALCA, CHGA
9positive regulation of cAMP biosynthetic processGO:03081910.2CALCA, GHRHR, GHRH, PTHLH
10positive regulation of insulin-like growth factor receptor signaling pathwayGO:04356810.2GHRHR, GHRH
11negative regulation of cell sizeGO:04579210.2TSC2, TSC1
12MAPK cascadeGO:00016510.2INS, RET, MEN1
13positive regulation of glycogen biosynthetic processGO:04572510.1INS, IGF2
14determination of adult lifespanGO:00834010.1GHRHR, POU1F1
15adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:00718910.1PTHLH, GHRH, GHRHR, CALCA, GCGR
16insulin receptor signaling pathwayGO:00828610.0TSC2, TSC1, INS, IGF2
17negative regulation of cell proliferationGO:0082859.9MEN1, SST, POU1F1, PTHLH, TSC1, TSC2
18cell-cell signalingGO:0072679.8CALCA, GHRH, IAPP, SST, PCSK1, INS
19positive regulation of cell proliferationGO:0082849.8VIP, GHRHR, GHRH, IGF2, POU1F1, INS
20G-protein coupled receptor signaling pathwayGO:0071869.6INS, SST, GAST, VIP

Molecular functions related to Islet Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:00515910.1INS, IGF2
2hormone activityGO:0051799.0PTHLH, VIP, CALCA, GAST, IAPP, SST

Products for genes affiliated with Islet Cell Tumor

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  • Proteins
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Sources for Islet Cell Tumor

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet