MCID: ISL001
MIFTS: 54

Islet Cell Tumor

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Islet Cell Tumor

MalaCards integrated aliases for Islet Cell Tumor:

Name: Islet Cell Tumor 37 12 51 14 69
Well Differentiated Pancreatic Endocrine Tumor 69
Malignant Neoplasm of Endocrine Pancreas 69
Malignant Tumor of Endocrine Pancreas 12
Malignant Pancreatic Endocrine Tumor 12
Pancreatic Endocrine Carcinoma 69
Pancreatic Endocrine Neoplasm 12
Endocrine Pancreas Cancer 12
Carcinoma Islet Cell 51
Islet Cell Neoplasm 12
Adenoma, Islet Cell 41
Islet Cell Tumour 12

Classifications:



Summaries for Islet Cell Tumor

Disease Ontology : 12 A pancreatic cancer that is located in the pancreatic islet cells.

MalaCards based summary : Islet Cell Tumor, also known as well differentiated pancreatic endocrine tumor, is related to pancreatic islet cell tumors and insulinoma. An important gene associated with Islet Cell Tumor is SST (Somatostatin), and among its related pathways/superpathways are Signaling by GPCR and G alpha (s) signalling events. The drugs Everolimus and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include the pancreatic islet cells, pancreas and pancreatic islet, and related phenotypes are cardiovascular system and endocrine/exocrine gland

Related Diseases for Islet Cell Tumor

Diseases related to Islet Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 179)
# Related Disease Score Top Affiliating Genes
1 pancreatic islet cell tumors 32.2 CALCA GAST INS MEN1 SST
2 insulinoma 31.4 CHGA INS MEN1 SST
3 somatostatinoma 31.0 CALCA CHGA INS SST VIP
4 vipoma 30.6 CALCA CHGA GAST SST VIP
5 duodenitis 30.4 GAST INS
6 hypercalcemia, infantile, 1 30.1 CALCA PTHLH
7 glucagonoma 29.8 CHGA SST VIP
8 duodenal ulcer 29.7 GAST INS SST
9 zollinger-ellison syndrome 29.5 CHGA GAST MEN1 SST
10 multiple endocrine neoplasia 29.5 CALCA CHGA MEN1
11 hyperinsulinemic hypoglycemia, familial, 2 29.2 CHGA GAST IGF2 INS SST
12 acromegaly 29.2 IGF2 INS MEN1 SST
13 pheochromocytoma 28.5 CALCA CHGA MEN1 SST VIP
14 multiple endocrine neoplasia, type i 28.4 CHGA GAST INS MEN1 SST VIP
15 hyperparathyroidism 28.0 CALCA CHGA GAST MEN1 PTHLH
16 gastrinoma 27.8 CHGA GAST INS MEN1 SST VIP
17 pheochromocytoma--islet cell tumor syndrome 12.3
18 pancreatic neuroendocrine tumor 11.7
19 mahvash disease 11.2
20 pancreatic endocrine carcinoma 11.0
21 pancreatitis 10.7
22 hypoglycemia 10.6
23 pylorospasm 10.4 GAST SST
24 postcholecystectomy syndrome 10.4 GAST SST
25 adenoma of the pancreas 10.4 CHGA SST
26 autoimmune atrophic gastritis 10.4 CHGA GAST
27 retinitis pigmentosa 40 10.4 GAST SST
28 duodenogastric reflux 10.4 GAST SST
29 pituitary carcinoma 10.4 CHGA SST
30 pernicious anemia 10.4 GAST SST
31 goblet cell carcinoid 10.4 CHGA GAST
32 pancreatoblastoma 10.4 CHGA SST
33 non-functioning pancreatic endocrine tumor 10.4 CHGA GAST
34 postural hypotension 10.4 INS SST
35 hyperpituitarism 10.3 INS SST
36 dumping syndrome 10.3 INS SST
37 spinal canal and spinal cord meningioma 10.3 CHGA IGF2
38 hypoglycemic coma 10.3 IGF2 INS
39 type 1 diabetes mellitus 2 10.3 IGF2 INS
40 spinal meningioma 10.3 CHGA IGF2
41 sclerosing hepatic carcinoma 10.3 CHGA PTHLH
42 secretory diarrhea 10.3 SST VIP
43 phaeochromocytoma 10.3 CHGA SST
44 cryptosporidiosis 10.3 SST VIP
45 liver sarcoma 10.3 CHGA PTHLH
46 granulosa cell tumor of the ovary 10.3 CHGA INS
47 pituitary-dependent cushing's disease 10.2 INS SST
48 gastric neuroendocrine tumor 10.2 CALCA GAST
49 prolactin producing pituitary tumor 10.2 CALCA SST
50 fetal macrosomia 10.2 IGF2 INS

Graphical network of the top 20 diseases related to Islet Cell Tumor:



Diseases related to Islet Cell Tumor

Symptoms & Phenotypes for Islet Cell Tumor

MGI Mouse Phenotypes related to Islet Cell Tumor:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.88 IGF2 VIP INS MEN1 CHGA PTHLH
2 endocrine/exocrine gland MP:0005379 9.87 VIP INS MEN1 CHGA PTHLH GAST
3 homeostasis/metabolism MP:0005376 9.86 SST IGF2 VIP INS MEN1 CHGA
4 digestive/alimentary MP:0005381 9.85 IGF2 INS MEN1 PTHLH GAST SST
5 immune system MP:0005387 9.7 SST IGF2 VIP INS MEN1 PTHLH
6 mortality/aging MP:0010768 9.56 SST IGF2 VIP INS MEN1 CHGA
7 reproductive system MP:0005389 9.1 IGF2 VIP INS MEN1 CHGA PTHLH

Drugs & Therapeutics for Islet Cell Tumor

Drugs for Islet Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 178)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Everolimus Approved Phase 4,Phase 3,Phase 2,Phase 1 159351-69-6 6442177
2
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
3
Sirolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 53123-88-9 46835353 6436030 5284616
4
Sunitinib Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 341031-54-7, 557795-19-4 5329102
5
Somatostatin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 38916-34-6, 51110-01-1 53481605
6
Pancrelipase Approved, Investigational Phase 4,Phase 2,Phase 1 53608-75-6
7 Pancreatic Polypeptide Investigational Phase 4,Phase 2,Phase 3,Phase 1 59763-91-6
8 Liver Extracts Phase 4,Phase 3,Phase 2,Phase 1
9 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1
10 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Phase 1
11 Antifungal Agents Phase 4,Phase 3,Phase 2,Phase 1
12 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
13 Immunosuppressive Agents Phase 4,Phase 2,Phase 3,Phase 1
14 Angiogenesis Inhibitors Phase 4,Phase 2,Phase 3,Phase 1
15 Angiogenesis Modulating Agents Phase 4,Phase 2,Phase 3,Phase 1
16 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
17 Hormones Phase 4,Phase 3,Phase 2,Phase 1
18 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
19 Hypoglycemic Agents Phase 4,Phase 2,Phase 1
20 pancreatin Phase 4,Phase 2,Phase 1
21 insulin Phase 4,Phase 2
22 Insulin, Globin Zinc Phase 4,Phase 2
23 Fluorodeoxyglucose F18 Phase 4,Phase 2
24
Bevacizumab Approved, Investigational Phase 2, Phase 3 216974-75-3
25
Fluorouracil Approved Phase 2, Phase 3 51-21-8 3385
26
Levoleucovorin Approved, Investigational Phase 2, Phase 3,Phase 1 68538-85-2
27
Oxaliplatin Approved, Investigational Phase 2, Phase 3,Phase 1 61825-94-3 43805 6857599 5310940 9887054
28 lanreotide Approved Phase 3,Phase 2 108736-35-2
29
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
30
Streptozocin Approved, Investigational Phase 3,Phase 2 18883-66-4 29327
31
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
32
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3,Phase 1 59-30-3 6037
33
leucovorin Approved, Nutraceutical Phase 2, Phase 3, Phase 1 58-05-9 143 6006
34 Anesthetics Phase 3
35 Antimetabolites Phase 2, Phase 3, Phase 1
36 Antimetabolites, Antineoplastic Phase 2, Phase 3, Phase 1
37 Angiopeptin Phase 3,Phase 2
38 Pharmaceutical Solutions Phase 3
39 Adjuvants, Anesthesia Phase 3
40 Analgesics Phase 3
41 Analgesics, Opioid Phase 3
42 Anesthetics, General Phase 3
43 Anesthetics, Intravenous Phase 3
44 Central Nervous System Depressants Phase 3,Phase 2
45 Narcotics Phase 3
46 Peripheral Nervous System Agents Phase 3,Phase 2
47 Dihydroxyphenylalanine Phase 3
48 Dopamine Agents Phase 3
49 Neurotransmitter Agents Phase 3,Phase 2
50 Folate Nutraceutical Phase 2, Phase 3,Phase 1

Interventional clinical trials:

(show top 50) (show all 158)

# Name Status NCT ID Phase Drugs
1 Disease-Specific Questionnaire in Assessing Quality of Life in Patients With Gastrointestinal-Related Neuroendocrine Tumors Unknown status NCT00454376 Phase 4
2 Phase IV Study of the Safety and Efficacy of Everolimus in Adult Patients With Progressive pNET in China Recruiting NCT02842749 Phase 4 everolimus
3 Nonfunctional Pancreatic NET and PET Imaging Recruiting NCT02621541 Phase 4
4 Clinical Effectiveness of Serum Chromogranin A Levels on Diagnostic of Pancreatic Neuroendocrine Tumors Active, not recruiting NCT02759718 Phase 4
5 A Study Of The Efficacy And Safety Of Sunitinib In Patients With Advanced Well-Differentiated Pancreatic Neuroendocrine Tumors Active, not recruiting NCT01525550 Phase 4 sunitinib
6 Pasireotide Treatment for Neuroendocrine Tumor Withdrawn NCT02779257 Phase 4 Pasireotide;Diazoxide
7 Efficacy and Safety of Radiofrequency Ablation in Pancreatic Neuroendocrine and Cystic Tumor Unknown status NCT02330497 Phase 3
8 Combination Chemotherapy and Bevacizumab in Treating Patients With Advanced Neuroendocrine Tumors Unknown status NCT00227617 Phase 2, Phase 3 5-fluorouracil;leucovorin;oxaliplatin
9 Study of Lanreotide Autogel 120 mg in Patients With Non-functioning Entero- Pancreatic Endocrine Tumour Completed NCT00842348 Phase 3 lanreotide (Autogel formulation)
10 Study of Lanreotide Autogel in Non-functioning Entero-pancreatic Endocrine Tumours Completed NCT00353496 Phase 3 lanreotide (Autogel formulation);Placebo
11 Efficacy and Safety of Everolimus (RAD001) Compared to Placebo in Patients With Advanced Neuroendocrine Tumors Completed NCT00510068 Phase 3 Everolimus;Everolimus Placebo
12 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
13 A Study Evaluating Lanreotide as Maintenance Therapy in Patients With Non-Resectable Duodeno-Pancreatic Neuroendocrine Tumors (REMINET) Recruiting NCT02288377 Phase 2, Phase 3 lanreotide;Placebo
14 Phase III Study of Sulfatinib in Treating Advanced Pancreatic Neuroendocrine Tumors Recruiting NCT02589821 Phase 3 Sulfatinib
15 Efficacy and Safety of Everolimus and (STZ-5FU) Given One Upfront the Other Upon Progression in Advanced pNET Recruiting NCT02246127 Phase 3 Drug: Everolimus;STZ-5FU
16 18F-DOPA PET Imaging: an Evaluation of Biodistribution and Safety Recruiting NCT03042416 Phase 3 18F-DOPA
17 Non-functioning Pancreatic Neuroendocrine Tumors in MEN1: Somatostatin Analogs Versus NO Treatment Not yet recruiting NCT02705651 Phase 3 Somatostatin-Analog
18 Cabozantinib S-malate in Treating Patients With Neuroendocrine Tumors Previously Treated With Everolimus That Are Locally Advanced, Metastatic, or Cannot Be Removed by Surgery Not yet recruiting NCT03375320 Phase 3 Cabozantinib S-malate
19 A Study Of Sunitinib Compared To Placebo For Patients With Advanced Pancreatic Islet Cell Tumors Terminated NCT00428597 Phase 3 sunitinib malate;Placebo
20 68-Ga-labeled Octreotide Analogues PET in Duodenal-pancreatic Neuroendocrine Tumours Unknown status NCT01673906 Phase 2 Diagnostic work up
21 Activity and Safety of Everolimus+Octreotide LAR+Metformin in Advanced Pancreatic Well-differentiated NETs Unknown status NCT02294006 Phase 2 Everolimus plus Octreotide LAR plus Metformin
22 Single Arm Trial With Combination of Everolimus and Letrozole in Treatment of Platinum Resistant Relapse or Refractory or Persistent Ovarian Cancer/Endometrial Cancer Unknown status NCT02188550 Phase 2 everolimus and letrozole
23 Recombinant Anti-tumor and Anti-virus Protein for Injection to Treat Advanced Neuroendocrine Tumors Unknown status NCT02455596 Phase 2 Recombinant anti-tumor and anti-virus protein for injection (Novaferon)
24 BEZ235 Phase II Trial in Patients With Advanced Pancreatic Neuroendocrine Tumors (pNET) After Failure of mTOR Inhibitor Therapy. Completed NCT01658436 Phase 2 BEZ235 (Stage 1)
25 Chemotherapy Plus Endostatin in Advanced Pancreatic Neuroendocrine Tumor Completed NCT01845675 Phase 2 temozolomide or dacarbazine-based chemotherapy, endostatin
26 AMG 479 in Advanced Carcinoid and Pancreatic Neuroendocrine Tumors Completed NCT01024387 Phase 2 AMG 479
27 Efficacy And Safety Of Sunitinib In Patients With Advanced Well-Differentiated Pancreatic Neuroendocrine Tumors Completed NCT01121562 Phase 2 Sunitinib
28 A Trial to Assess the Activity and Safety of Palbociclib in Patients With Well and Moderately Differentiated Metastatic Pancreatic Neuroendocrine Tumors (pNET) Completed NCT02806648 Phase 2 Palbociclib
29 Combination Chemotherapy in Patients With Zollinger-Ellison Syndrome and Tumors of the Pancreas Completed NCT00001165 Phase 2 combined chemotherapy with streptozotocin, 5-fluorouracil, and doxorubicin
30 Safety/Efficacy of Everolimus in Adults With Advanced Pancreatic Neuroendocrine Cancer Not Responsive to Chemotherapy Completed NCT00363051 Phase 2 Everolimus 10 mg;Octreotide Depot
31 Combination Chemotherapy as First-Line Therapy in Treating Patients With Locally Advanced or Metastatic Neuroendocrine Tumors of the Duodenum or Pancreas That Cannot Be Removed By Surgery Completed NCT00416767 Phase 2 fluorouracil;irinotecan hydrochloride;leucovorin calcium
32 Interferon and Octreotide to Treat Zollinger-Ellison Syndrome and Advanced Non-B Islet Cell Cancer Completed NCT00001228 Phase 2 Interferon
33 Combination of Lanreotide Autogel 120mg and Temozolomide in Progressive GEP-NET Completed NCT02231762 Phase 2 Lanreotide Autogel 120 mg;Temozolomide (TMZ)
34 Capecitabine and Streptozocin With or Without Cisplatin in Treating Patients With Unresectable or Metastatic Neuroendocrine Tumors Completed NCT00602082 Phase 2 capecitabine;cisplatin;streptozocin
35 A Study of IMC-A12 in Islet Cell Cancer Completed NCT00781911 Phase 2 depot octreotide
36 Phase II Study of Sunitinib Malate Following Hepatic Artery Embolization Completed NCT00434109 Phase 2 Sunitinib malate
37 PS-341 in Treating Patients With Metastatic Neuroendocrine Tumors Completed NCT00017199 Phase 2 bortezomib
38 AMG 706 and Octreotide in Treating Patients With Low-Grade Neuroendocrine Tumors Completed NCT00427349 Phase 2 AMG 706;octreotide
39 RAD001 Plus Octreotide Depot in Metastatic or Unresectable Low Grade Neuroendocrine Carcinoma Completed NCT00113360 Phase 2 RAD001;Octreotide Depot
40 68Ga-OPS202 Study for Diagnostic Imaging of GEP NET Completed NCT02162446 Phase 1, Phase 2 68Ga-OPS202
41 Thalidomide in Treating Patients With Metastatic Neuroendocrine Tumors Completed NCT00027638 Phase 2 thalidomide
42 Pazopanib as Single Agent in Advanced NETs Completed NCT01280201 Phase 2 Pazopanib
43 The Use of Oral Omeprazole and Intravenous Pantoprazole in Patients With Hypersecretion of Gastric Acid Completed NCT00001191 Phase 2 Pantoprazole;Omeprazole
44 KPT-330 to Treat Poorly Differentiated Lung and Gastroenteropancreatic Tumors Completed NCT02250885 Phase 2 Selinexor
45 A Ph 2 Study of Fosbretabulin in Subjects w Pancreatic or Gastrointestinal Neuroendocrine Tumors w Elevated Biomarkers Completed NCT02132468 Phase 2 fosbretabulin tromethamine
46 Study of MK-2206 in Patients With Metastatic Neuroendocrine Tumors (NET) Completed NCT01169649 Phase 2 MK-2206
47 Isolated Hepatic Perfusion With Melphalan in Treating Patients With Primary Unresectable Liver Cancer or Liver Metastases Completed NCT00019786 Phase 2 isolated perfusion;melphalan
48 Temsirolimus in Treating Patients With Metastatic Neuroendocrine Carcinoma Completed NCT00093782 Phase 2 temsirolimus
49 68Ga-DOTATATE PET Scan in Neuroendocrine Cancer Completed NCT01396382 Phase 2
50 Sorafenib Tosylate in Treating Patients With Progressive Metastatic Neuroendocrine Tumors Completed NCT00131911 Phase 2 sorafenib tosylate

Search NIH Clinical Center for Islet Cell Tumor

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: adenoma, islet cell

Genetic Tests for Islet Cell Tumor

Anatomical Context for Islet Cell Tumor

The Foundational Model of Anatomy Ontology organs/tissues related to Islet Cell Tumor:

18
The Pancreatic Islet Cells

MalaCards organs/tissues related to Islet Cell Tumor:

38
Pancreas, Pancreatic Islet, Liver, Breast, Lung, Endothelial, Lymph Node

Publications for Islet Cell Tumor

Articles related to Islet Cell Tumor:

(show top 50) (show all 351)
# Title Authors Year
1
Levels of glucose-regulatory hormones in patients with non-islet cell tumor hypoglycemia: including a review of the literature. ( 28529277 )
2017
2
A Case of Non-Islet Cell Tumor Hypoglycemia (NICTH) Associated with Gastrointestinal Stromal Tumor (GIST). ( 28900071 )
2017
3
Characterization of pancreatic islet cell tumors and renal tumors induced by a combined treatment of streptozotocin and nicotinamide in male SD rats. ( 28390812 )
2017
4
Non-islet cell tumor hypoglycemia caused by intrathoracic solitary fibrous tumor: a case report. ( 27061182 )
2016
5
Non-islet cell tumor hypoglycemia caused by a big insulin-like growth factor II- producing hepatocellular carcinoma:an autopsy case report. ( 27916774 )
2016
6
The Transformation of a Nonfunctioning Islet Cell Tumor of the Pancreas into a Proinsulinoma under Conditions of Lung Metastasis. ( 25832942 )
2015
7
Non-Islet Cell Tumor Hypoglycemia Is Caused by Big IGF-II in a Patient with a Carcinosarcoma of the Uterus. ( 26666605 )
2015
8
Multiple hepatocellular adenomas presenting in a male 8 years post-pancreaticoduodenectomy for islet cell tumor of the pancreas. ( 25810673 )
2015
9
Fatal hepatitis B reactivation in a patient with islet cell tumor on octreotide and sirolimus. ( 26487953 )
2015
10
Characterization of a pancreatic islet cell tumor in a polar bear (Ursus maritimus). ( 25273481 )
2014
11
Bioactive insulin-like growth factors as a possible molecular target for non-islet cell tumor hypoglycemia. ( 25535894 )
2014
12
A 94-year-old man with recurrent hypoglycemia caused by non-islet cell tumor hypoglycemia (NICTH). ( 25780362 )
2014
13
Nonfunctional islet cell tumor of the pancreas in a patient with tuberous sclerosis: a case report with literature review. ( 24678435 )
2014
14
Management of Non-Islet-Cell Tumor Hypoglycemia: A Clinical Review. ( 24423303 )
2013
15
GPR119 expression in normal human tissues and islet cell tumors: evidence for its islet-gastrointestinal distribution, expression in pancreatic beta and alpha cells, and involvement in islet function. ( 22883930 )
2013
16
Nesidioblastosis and Pancreatic Non-functioning Islet Cell Tumor in an Adult with Type 2 Diabetes Mellitus. ( 24255640 )
2013
17
Metastatic Insulinoma Following Resection of Nonsecreting Pancreatic Islet Cell Tumor: A Case Report and Review of the Literature. ( 26425568 )
2013
18
Surgical treatment of pancreatic islet cell tumor: report of 44 cases. ( 24719954 )
2013
19
Non-islet cell tumor hypoglycemia associated with recurrent carcinosarcoma of the ovary. ( 23512392 )
2013
20
Non-islet cell tumor-induced hypoglycemia: a report of five cases and brief review of the literature. ( 24616774 )
2013
21
Non-Islet Cell Tumor-Induced Hypoglycemia Associated with Macronodular Pulmonary Metastases from Poorly Differentiated Thyroid Carcinoma. ( 23697382 )
2013
22
Gastric neuroendocrine carcinoma with non-islet cell tumor hypoglycemia associated with enhanced production of insulin-like growth factor II. ( 23545670 )
2013
23
Severe hypoglycemia with "Big"-IGF-2 oversecretion by a giant phyllode tumor of the breast: a rare case of non-islet cell tumor-induced hypoglycemia (NICTH). ( 22867750 )
2012
24
Non-islet cell tumor hypoglycemia at the second recurrence of malignant solitary fibrous tumor in the retroperitoneum and pelvis: a case report. ( 22949904 )
2012
25
Gastrointestinal stromal tumor of the pelvic soft tissue presenting with symptomatic hypoglycemia: A case report and brief review of current literature of non-islet cell tumor-induced hypoglycemia. ( 24371628 )
2012
26
Sorafenib inhibits tumor growth and improves survival in a transgenic mouse model of pancreatic islet cell tumors. ( 23346016 )
2012
27
Recurrent solitary fibrous tumor of the pleura with malignant transformation and non-islet cell tumor-induced hypoglycemia due to paraneoplastic overexpression and secretion of high-molecular-weight insulin-like growth Factor II. ( 23207122 )
2012
28
Retrospective Review of Cross Sectional Imaging Findings of Pancreatic Non-functional Islet Cell Tumor (NFICT) and its Hepatic Metastases. ( 22043378 )
2011
29
Non-islet cell tumor hypoglycemia associated with uterine leiomyomata. ( 21550955 )
2011
30
Diabetic ketoacidosis with concurrent pancreatitis, pancreatic I^ islet cell tumor, and adrenal disease in an obese ferret (Mustela putorius furo). ( 21838985 )
2011
31
Pancreatic and peri-pancreatic lesions mimic pancreatic islet cell tumor in multidetector computed tomography. ( 21740785 )
2011
32
Diffusion weighted MR imaging of pancreatic islet cell tumors. ( 19264435 )
2010
33
Metastatic pancreatic polypeptide-secreting islet cell tumor in a dog. ( 20698942 )
2010
34
Systematic comparison of sporadic and syndromic pancreatic islet cell tumors. ( 20660572 )
2010
35
Hepatic abscess after yttrium-90 radioembolization for islet-cell tumor hepatic metastasis. ( 19688373 )
2010
36
A case of gastric cancer with non-islet cell tumor hypoglycemia detected by insulin-like growth factor II. ( 20618739 )
2010
37
Non-islet cell tumor hypoglycemia. ( 19345293 )
2009
38
Pancreatic islet cell tumor secreting insulin-like growth factor type-II in a dog. ( 19780935 )
2009
39
Homozygous P86S mutation of the human glucagon receptor is associated with hyperglucagonemia, alpha cell hyperplasia, and islet cell tumor. ( 19657311 )
2009
40
Insulinoma with six islet cell tumors associated with severe hypoglycemia. ( 19525595 )
2009
41
Successful control of intractable hypoglycemia using rapamycin in an 86-year-old man with a pancreatic insulin-secreting islet cell tumor and metastases. ( 19567519 )
2009
42
Spontaneous pancreatic islet cell tumor in a black and white colobus monkey (Colobus guereza kikuyuensis). ( 18269522 )
2008
43
Nesidioblastosis and hyperplasia of alpha cells, microglucagonoma, and nonfunctioning islet cell tumor of the pancreas: review of the literature. ( 18437091 )
2008
44
Hypoglycemia associated with the production of insulin-like growth factor II in a pancreatic islet cell tumor: a case report. ( 18490836 )
2008
45
Non-islet-cell tumor hypoglycemia and lactic acidosis in a child with congenital HIV and Burkitt's lymphoma. ( 18825882 )
2008
46
Successful treatment of non-islet cell tumor hypoglycemia in hepatocellular carcinoma with doxorubicin. ( 18278497 )
2008
47
Islet cell tumor of the pancreas: increasing diagnosis after instituting ultrasonography-guided fine needle aspiration. ( 18323274 )
2008
48
Spectrum of functioning islet cell tumor on multislice computed tomography: experience on 70 patients. ( 18437902 )
2008
49
Solitary fibrous tumor associated with non-islet cell tumor hypoglycemia. ( 17588442 )
2007
50
Generation and characterization of islet cell tumor in pTet-on/pTRE-SV40Tag double-transgenic mice model. ( 17697978 )
2007

Variations for Islet Cell Tumor

Expression for Islet Cell Tumor

Search GEO for disease gene expression data for Islet Cell Tumor.

Pathways for Islet Cell Tumor

Pathways related to Islet Cell Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.45 CALCA GAST IGF2 INS MEN1 PTHLH
2 11.3 CALCA PTHLH VIP
3 10.98 IGF2 INS
4 9.47 GAST VIP

GO Terms for Islet Cell Tumor

Cellular components related to Islet Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 CALCA CHGA GAST IGF2 INS PTHLH
2 extracellular region GO:0005576 9.23 CALCA CHGA GAST IGF2 INS PTHLH

Biological processes related to Islet Cell Tumor according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.8 IGF2 INS PTHLH VIP
2 G-protein coupled receptor signaling pathway GO:0007186 9.63 CALCA GAST INS PTHLH SST VIP
3 cell-cell signaling GO:0007267 9.62 CALCA INS PTHLH SST
4 regulation of protein localization GO:0032880 9.56 INS VIP
5 positive regulation of cAMP biosynthetic process GO:0030819 9.55 CALCA PTHLH
6 response to heat GO:0009408 9.54 CALCA SST
7 positive regulation of mitotic nuclear division GO:0045840 9.52 IGF2 INS
8 positive regulation of blood vessel diameter GO:0097755 9.51 CALCA INS
9 osteoblast development GO:0002076 9.48 MEN1 PTHLH
10 positive regulation of glycogen biosynthetic process GO:0045725 9.46 IGF2 INS
11 positive regulation of cAMP metabolic process GO:0030816 9.43 CALCA CHGA
12 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 9.43 CALCA PTHLH VIP
13 positive regulation of insulin receptor signaling pathway GO:0046628 9.4 IGF2 INS
14 negative regulation of blood vessel diameter GO:0097756 9.37 CHGA INS
15 cellular protein metabolic process GO:0044267 9.26 CALCA IGF2 INS MEN1
16 regulation of receptor activity GO:0010469 9.17 CALCA GAST IGF2 INS PTHLH SST

Molecular functions related to Islet Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.17 CALCA GAST IGF2 INS PTHLH SST
2 insulin receptor binding GO:0005158 9.16 IGF2 INS
3 insulin-like growth factor receptor binding GO:0005159 8.96 IGF2 INS

Sources for Islet Cell Tumor

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33 ICD10 via Orphanet
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