MCID: ISL001
MIFTS: 53

Islet Cell Tumor malady

Cancer diseases, Endocrine diseases categories

Summaries for Islet Cell Tumor

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34MalaCards
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MalaCards: Islet Cell Tumor, also known as benign islet cell tumor, is related to hypoglycemia and pancreatic islet cell tumors. An important gene associated with Islet Cell Tumor is IAPP (islet amyloid polypeptide), and among its related pathways are Selected targets of CREB1 and Peptide ligand-binding receptors. The compounds 111in-pentetreotide and 5-hydroxytryptophan have been mentioned in the context of this disorder. Affiliated tissues include pancreas, pancreatic islet and liver, and related mouse phenotypes are cardiovascular system and endocrine/exocrine gland.

Aliases & Classifications for Islet Cell Tumor

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11DISEASES, 9Disease Ontology, 63UMLS, 46Novoseek, 59SNOMED-CT, 36MeSH, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Endocrine diseases


Aliases & Descriptions:

islet cell tumor 9 63
benign islet cell tumor 9 63
pancreatic endocrine carcinoma 11
pancreatic endocrine neoplasm 9
tumor of endocrine pancreas 9
islet cell tumour, benign 9
benign islet cell tumour 9
carcinoma islet cell 46
islet cell neoplasm 9
islet cell tumour 9


Related Diseases for Islet Cell Tumor

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18GeneCards, 19GeneDecks
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Diseases related to Islet Cell Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 103)
idRelated DiseaseScoreTop Affiliating Genes
1hypoglycemia31.5SST, IAPP, CHGA
2pancreatic islet cell tumors31.4MEN1, SST, IAPP, CHGA, VIP, PTHLH
3diarrhea30.9SST, CHGA, VIP
4hyperinsulinism30.8SST, IAPP
5cushing's syndrome30.8SST
6zollinger-ellison syndrome30.7MEN1, SST, CHGA
7multiple endocrine neoplasia30.6VIP, CHGA, MEN1
8acromegaly30.6MEN1, SST, VIP
9hypercalcemia30.6MEN1, IAPP, CHGA, PTHLH
10adenoma30.5CHGA, SST, MEN1
11somatostatinoma30.5SST, CHGA, VIP
12pheochromocytoma30.5VIP, CHGA, IAPP, SST, MEN1
13insulinoma30.4MEN1, SST, IAPP, CHGA, VIP
14glucagonoma30.3VIP, CHGA, SST, MEN1
15neurofibromatosis30.3SST, MEN1
16acute pancreatitis30.2SST, IAPP
17thyroid cancer30.2SST, CHGA
18neuroendocrine carcinoma30.2MEN1, SST, CHGA
19hyperparathyroidism30.2PTHLH, CHGA, MEN1
20vipoma30.1MEN1, SST, CHGA, VIP
21carcinoid syndrome30.0VIP, CHGA, IAPP, SST, MEN1
22gastrinoma30.0VIP, CHGA, IAPP, SST, MEN1
23adenocarcinoma29.9PTHLH, VIP, CHGA, IAPP, SST, MEN1
24pancreatitis11.2
25pancreatic endocrine carcinoma10.7
26pheochromocytoma-islet cell tumor syndrome10.5
27duodenitis10.4
28hypokalemia10.4
29von hippel-lindau disease10.4
30hepatitis10.4
31thyroiditis10.4
32somatostatin analog10.4
33solitary fibrous tumor10.4
34portal hypertension10.3
35gastrointestinal stromal tumor10.3
36hypertension10.3
37mahvash disease10.3
38pancreatic adenoma10.2
39recurrent acute pancreatitis10.2
40steatorrhea10.1
41arteriovenous fistula10.1
42diabetic ketoacidosis10.1
43duodenal ulcer10.1
44cholera10.1
45cystadenoma10.1
46burkitt's lymphoma10.1
47acinar cell carcinoma10.1
48cholelithiasis10.1
49tuberous sclerosis10.1
50extramedullary plasmacytoma10.1

Graphical network of the top 20 diseases related to Islet Cell Tumor:



Diseases related to islet cell tumor

Symptoms for Islet Cell Tumor

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Drugs & Therapeutics for Islet Cell Tumor

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Islet Cell Tumor

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Anatomical Context for Islet Cell Tumor

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34MalaCards
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MalaCards organs/tissues related to Islet Cell Tumor:

34
Pancreas, Pancreatic islet, Liver, Pituitary, Thyroid, B cells, Breast, Bone, Ovary, Testes, Spinal cord

Animal Models for Islet Cell Tumor or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Islet Cell Tumor:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.1MEN1, CHGA, VIP, PTHLH
2MP:00053798.0MEN1, CHGA, VIP, PTHLH
3MP:00053787.9PTHLH, CHGA, IAPP, SST, MEN1
4MP:00053897.8PTHLH, VIP, CHGA, MEN1
5MP:00053877.6PTHLH, VIP, IAPP, SST, MEN1
6MP:00053767.2MEN1, SST, IAPP, CHGA, VIP, PTHLH

Publications for Islet Cell Tumor

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53PubMed
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Articles related to Islet Cell Tumor:

(show top 50)    (show all 328)
idTitleAuthorsYear
1
Management of Non-Islet-Cell Tumor Hypoglycemia: A Clinical Review. (24423303)
2013
2
Severe hypoglycemia with "Big"-IGF-2 oversecretion by a giant phyllode tumor of the breast: a rare case of non-islet cell tumor-induced hypoglycemia (NICTH). (22867750)
2012
3
Spectrum of functioning islet cell tumor on multislice computed tomography: experience on 70 patients. (18437902)
2008
4
Generation and characterization of islet cell tumor in pTet-on/pTRE-SV40Tag double-transgenic mice model. (17697978)
2007
5
A minute nonfunctioning islet cell tumor demonstrating malignant features. (15754106)
2005
6
Surgical treatment of nonfunctioning islet cell tumor: report of 41 cases. (15313691)
2004
7
A wolf in sheep's clothing: a non-functioning islet cell tumor of the pancreas masquerading as a microcystic (serous cystic) adenoma. (15254352)
2004
8
Parathyroid hormone-related protein induced coupled increases in bone formation and resorption markers for 7 years in a patient with malignant islet cell tumors. (12009004)
2002
9
Antibodies directed against the E region of pro-insulin-like growth factor-II used to evaluate non-islet cell tumor-induced hypoglycemia. (12324491)
2002
10
Streptozocin for treatment of pancreatic islet cell tumors in dogs: 17 cases (1989-1999). (12322919)
2002
11
High frequency loss of heterozygosity in von Hippel-Lindau (VHL)-associated and sporadic pancreatic islet cell tumors: evidence for a stepwise mechanism for malignant conversion in VHL tumorigenesis. (11929809)
2002
12
Malignant islet cell tumor of the pancreas associated with portal venous thrombus. (11511884)
2001
13
Immunocytochemical localization of prohormone convertase 1/3 and 2 in pancreatic islet cells and islet cell tumors. (11484919)
2001
14
Insulin and somatostatin releasing islet cell tumor caused hypoglycemia. (11334393)
2001
15
Functional pancreatic islet cell tumors with liver metastasis: the role of cytoreductive surgery and transcatheter arterial chemoembolization: a report of five cases. (9884450)
1998
16
Hepatoma with severe non-islet cell tumor hypoglycemia. (9647037)
1998
17
Serum high molecular weight form of insulin-like growth factor II from patients with non-islet cell tumor hypoglycemia is O-glycosylated. (9709962)
1998
18
Fine-needle aspiration of pancreatic extramedullary plasmacytoma: possible confusion with islet cell tumor. (7924813)
1994
19
Aneuploid islet cell tumor with late metastasis. (7991294)
1994
20
Giant nonfunctioning islet cell tumor requiring pancreaticoduodenectomy and complete liver revascularization. (8101891)
1993
21
Characterization of insulin-like growth factor II (IGF-II) and IGF binding proteins in patients with non-islet-cell tumor hypoglycemia. (7524924)
1993
22
Duct-islet cell tumor of the pancreas. A case report with immunohistochemical and electron microscopic findings. (2558493)
1989
23
Islet cell tumor presenting as massive upper gastrointestinal bleeding in pregnancy. (2839980)
1988
24
Metastatic islet cell tumor with ACTH, gastrin, and glucagon secretion. Clinical and pathologic studies with multiple therapies. (3032401)
1987
25
Pancreatic islet cell tumors. (3029883)
1987
26
Insulin-producing islet cell tumor in an ectopic pancreas of a red fox (Vulpes vulpes). (6325727)
1984
27
Clonal analysis of insulin and somatostatin secretion and L-dopa decarboxylase expression by a rat islet cell tumor. (6129963)
1983
28
Metastasizing pancreatic islet cell tumors in the rat. (6279704)
1982
29
Rupture of a giant non-functioning pancreatic islet cell tumor following minimal trauma. (6258461)
1981
30
Glucagon secreting clones of rat islet cell tumor. (6257606)
1980
31
Serially transplantable chemically induced rat islet cell tumor. (6250800)
1980
32
Coexistence of bilateral pheochromocytoma and pancreatic islet cell tumor: report of a case and review of the literature. (215301)
1978
33
Remission of hypoglycemia after partial resection of a metastatic islet cell tumor. (208422)
1978
34
Vascular liver nodules caused by an islet cell tumor. (179758)
1976
35
Recent advances in management of functioning islet cell tumor. (4335281)
1972
36
Hydroxyindole-producing tumors of the pancreas. Carcinoid-islet cell tumor and oat cell carcinoma. (4340726)
1972
37
Islet cell tumor with hypoglycemia. (4323689)
1971
38
Adipose tissue lipolysis in golden hamsters with chronic hypoglycemia and hyperinsulinemia due to a transplantable islet cell tumor. (4329446)
1970
39
Pathogenesis of hypoglycemia in hamsters with a transplantable islet-cell tumor. (4303975)
1969
40
Prolonged remission of diarrhea due to nonbeta islet cell tumor of the pancreas by radiotherapy. (4296999)
1968
41
Giant nonfunctioning islet cell tumor. Survival after pancreaticoduodenectomy. (4296368)
1968
42
PEPTIC ULCER WITH ISLET CELL TUMOR: A REAPPRAISAL. (14215844)
1964
43
DIARRHEA ASSOCIATED WITH PANCREATIC ISLET-CELL TUMORS. (14116905)
1964
44
Islet cell tumor. Diarrhea, and hypopotassemia (the Zollinger-Ellison syndrome?). (13903135)
1962
45
The syndrome of refractory watery diarrhea and hypokalemia in patients with a non-insulin-secreting islet cell tumor. A further case study and review of the literature. (14476287)
1962
46
Pancreatic islet cell tumors and renal tumors in the male rat following neutron exposure. (14038763)
1961
47
Clinics on endocrine and metabolic diseases. 3. Hyperinsulinism: review of 95 cases of functioning pancreatic islet cell tumors. (13748469)
1960
48
Islet-cell tumor of the pancreas with hyperinsulinism; failure of surgical and alloxan treatment; report of a case. (13268201)
1955
49
Coma and hyperglycemia following islet-cell tumor removal. (14356522)
1955
50
Islet cell tumor of the pancreas: case report. (14838565)
1951

Variations for Islet Cell Tumor

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Expression for genes affiliated with Islet Cell Tumor

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Islet Cell Tumor

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Pathways for genes affiliated with Islet Cell Tumor

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51PathCards, 13EMD Millipore, 56Reactome, 39NCBI BioSystems Database, 31KEGG
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Compounds for genes affiliated with Islet Cell Tumor

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46Novoseek, 30IUPHAR, 12DrugBank, 25HMDB, 52PharmGKB, 62Tocris Bioscience, 3BitterDB
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Compounds related to Islet Cell Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 83)
idCompoundScoreTop Affiliating Genes
1111in-pentetreotide469.8CHGA, SST
25-hydroxytryptophan469.7CHGA, SST
3lanreotide46 3010.7SST, CHGA
4secretoneurin469.5CHGA, VIP
5tyr-3-octreotide469.5VIP, SST
6minigastrin469.5SST, VIP
7dacarbazine46 1210.5SST, CHGA
8streptozotocin469.5SST, CHGA, IAPP
9c-peptide469.5SST, CHGA, IAPP
10vanillylmandelic acid46 2510.5CHGA, VIP
11spantide469.5VIP, SST
12cyclophosphamide46 52 1211.2PTHLH, SST, CHGA
13catecholamine469.1CHGA, IAPP, VIP
14mibg469.1VIP, SST, CHGA
15oxyntomodulin46 6210.1VIP, CHGA, SST
165-hydroxyindoleacetic acid46 2510.1SST, CHGA, VIP
17propranolol46 30 52 25 1213.1CHGA, SST, VIP
18trifluoroethanol46 1210.0VIP, IAPP, PTHLH
19caffeine46 30 3 52 25 1214.0SST, CHGA, VIP
20carbachol46 30 1211.0CHGA, SST, VIP
215-hydroxytryptamine469.0VIP, SST, CHGA
22acth468.9SST, CHGA, VIP
23gnrh468.9VIP, CHGA, SST
24vitamin d468.9MEN1, PTHLH, CHGA
25gaba468.8SST, CHGA, VIP
26thyroxine46 259.8VIP, SST, PTHLH
27epinephrine46 25 1210.7SST, VIP, CHGA, IAPP
28histamine46 30 2510.7SST, IAPP, CHGA, VIP
29dopamine46 30 25 1211.6SST, VIP, IAPP, CHGA
30forskolin46 52 1210.6CHGA, IAPP, VIP, PTHLH
31ibmx46 62 3010.5PTHLH, VIP, SST, IAPP
32cyclic amp46 259.5PTHLH, VIP, CHGA, IAPP
33octreotide46 62 30 1211.5VIP, PTHLH, SST, CHGA
34nifedipine46 30 52 1211.5CHGA, PTHLH, VIP, SST
35thymidine46 259.5PTHLH, IAPP, MEN1, VIP
36nitric oxide46 25 1210.4PTHLH, VIP, CHGA, IAPP
37glucose468.4CHGA, PTHLH, IAPP, SST
38indomethacin46 30 62 1211.3PTHLH, IAPP, VIP
39estrogen468.1VIP, PTHLH, CHGA, MEN1
40isoproterenol46 129.1SST, VIP, CHGA, IAPP, PTHLH
41norepinephrine46 25 1210.1CHGA, SST, VIP, IAPP, PTHLH
42acetylcholine46 52 30 25 1212.1VIP, PTHLH, CHGA, SST, IAPP
43lactate468.1VIP, IAPP, SST, CHGA, PTHLH
44adenylate468.1IAPP, CHGA, PTHLH, VIP, SST
45testosterone46 62 25 1211.1PTHLH, SST, CHGA, IAPP, VIP
46dexamethasone46 52 30 1211.1VIP, PTHLH, CHGA, SST, IAPP
47arginine468.1CHGA, PTHLH, VIP, IAPP, SST
48serine468.0PTHLH, VIP, MEN1, IAPP, CHGA
49vegf467.9CHGA, SST, VIP, PTHLH, MEN1
50calcium46 52 25 1210.8MEN1, IAPP, VIP, PTHLH, CHGA

GO Terms for genes affiliated with Islet Cell Tumor

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17Gene Ontology
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Cellular components related to Islet Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:0430258.7SST, IAPP, VIP
2extracellular regionGO:0055767.3SST, IAPP, CHGA, VIP, PTHLH

Biological processes related to Islet Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1osteoblast developmentGO:0020769.3MEN1, PTHLH
2negative regulation of sequence-specific DNA binding transcription factor activityGO:0434339.3MEN1, PTHLH
3cell-cell signalingGO:0072678.8SST, IAPP, PTHLH
4negative regulation of cell proliferationGO:0082858.5PTHLH, SST, MEN1

Molecular functions related to Islet Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051798.1SST, IAPP, VIP, PTHLH

Products for genes affiliated with Islet Cell Tumor

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Sources for Islet Cell Tumor

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet