MCID: ISL001
MIFTS: 59

Islet Cell Tumor malady

Cancer diseases, Endocrine diseases categories
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Summaries for Islet Cell Tumor

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Disease Ontology:8 A pancreatic cancer that is located in the pancreatic islet cells.

MalaCards based summary: Islet Cell Tumor, also known as malignant tumor of endocrine pancreas, is related to pancreatic islet cell tumors and hypoglycemia. An important gene associated with Islet Cell Tumor is IAPP (islet amyloid polypeptide), and among its related pathways are Selected targets of CREB1 and Peptide ligand-binding receptors. The drug dacarbazine and the compounds 111in-pentetreotide and 5-hydroxytryptophan have been mentioned in the context of this disorder. Affiliated tissues include the pancreatic islet cells, pancreas and pancreatic islet, and related mouse phenotypes are cardiovascular system and endocrine/exocrine gland.

Aliases & Classifications for Islet Cell Tumor

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Islet Cell Tumor, Aliases & Descriptions:

Name: Islet Cell Tumor 30 8 62
Malignant Tumor of Endocrine Pancreas 8 62
Pancreatic Endocrine Carcinoma 10 62
Pancreatic Endocrine Neoplasm 8 62
Carcinoma Islet Cell 44 62
Islet Cell Neoplasm 8 62
 
Malignant Neoplasm of Endocrine Pancreas 62
Malignant Pancreatic Endocrine Tumour 62
Malignant Pancreatic Endocrine Tumor 8
Endocrine Pancreas Cancer 8
Islet Cell Tumour 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Endocrine diseases


Related Diseases for Islet Cell Tumor

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Diseases related to Islet Cell Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 107)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatic islet cell tumors31.9PTHLH, SST
2hypoglycemia31.5SST, IAPP, CHGA
3cushing's syndrome31.2SST
4hyperinsulinism31.0SST, IAPP
5diarrhea30.8SST, CHGA, VIP
6zollinger-ellison syndrome30.7MEN1, SST, CHGA
7multiple endocrine neoplasia30.5VIP, CHGA, MEN1
8neurofibromatosis30.5SST, MEN1
9acute pancreatitis30.5SST, IAPP
10adenoma30.5CHGA, SST, MEN1
11acromegaly30.4MEN1, SST, VIP
12somatostatinoma30.4SST, CHGA, VIP
13hypercalcemia30.3MEN1, IAPP, CHGA, PTHLH
14hyperparathyroidism30.1PTHLH, CHGA, MEN1
15prolactinoma30.0PTHLH, CHGA, SST, MEN1
16vipoma29.9MEN1, SST, CHGA, VIP
17glucagonoma29.9VIP, CHGA, SST, MEN1
18pheochromocytoma29.9VIP, CHGA, IAPP, SST, MEN1
19insulinoma29.8MEN1, SST, IAPP, CHGA, VIP
20carcinoid syndrome29.5VIP, CHGA, IAPP, SST, MEN1
21gastrinoma29.4VIP, CHGA, IAPP, SST, MEN1
22adenocarcinoma29.0PTHLH, VIP, CHGA, IAPP, SST, MEN1
23pancreatitis11.2
24pancreatic endocrine tumors10.6
25pheochromocytoma-islet cell tumor syndrome10.5
26intestinal disease10.4SST
27hepatitis10.4
28von hippel-lindau disease10.4
29hypokalemia10.4
30duodenitis10.4
31thyroiditis10.4
32somatostatin analog10.4
33solitary fibrous tumor10.4
34hypertension10.3
35tuberous sclerosis10.3
36gastrointestinal stromal tumor10.3
37portal hypertension10.3
38mahvash disease10.3
39diabetes insipidus10.2
40hyperinsulinemic hypoglycemia10.2CHGA, SST
41merkel cell carcinoma10.2CHGA, SST
42lung cancer10.2SST, CHGA
43factor vii deficiency10.2SST, CHGA
44pituitary gland disease10.2MEN1, SST
45pancreatic adenoma10.2
46recurrent acute pancreatitis10.2
47adrenal cortical adenoma10.2MEN1, CHGA
48steatorrhea10.2
49adenosquamous carcinoma10.1PTHLH, CHGA
50large cell carcinoma10.1PTHLH, CHGA

Graphical network of the top 20 diseases related to Islet Cell Tumor:



Diseases related to islet cell tumor

Symptoms for Islet Cell Tumor

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Drugs & Therapeutics for Islet Cell Tumor

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Drug clinical trials:

Search ClinicalTrials for Islet Cell Tumor

Search NIH Clinical Center for Islet Cell Tumor

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Islet Cell Tumor

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Anatomical Context for Islet Cell Tumor

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MalaCards organs/tissues related to Islet Cell Tumor:

32
Pancreas, Pancreatic islet, Liver, Thyroid, Pituitary, Bone, Breast, B cells, Spinal cord, Ovary, Testes

FMA organs/tissues related to Islet Cell Tumor:

14
The pancreatic islet cells

Animal Models for Islet Cell Tumor or affiliated genes

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MGI Mouse Phenotypes related to Islet Cell Tumor:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.1MEN1, CHGA, VIP, PTHLH
2MP:00053798.0MEN1, CHGA, VIP, PTHLH
3MP:00053787.9PTHLH, CHGA, IAPP, SST, MEN1
4MP:00053897.8PTHLH, VIP, CHGA, MEN1
5MP:00053877.6PTHLH, VIP, IAPP, SST, MEN1
6MP:00053767.2MEN1, SST, IAPP, CHGA, VIP, PTHLH

Publications for Islet Cell Tumor

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Articles related to Islet Cell Tumor:

(show top 50)    (show all 336)
idTitleAuthorsYear
1
Surgical treatment of pancreatic islet cell tumor: report of 44 cases. (24719954)
2013
2
Management of Non-Islet-Cell Tumor Hypoglycemia: A Clinical Review. (24423303)
2013
3
Non-islet cell tumor-induced hypoglycemia: a report of five cases and brief review of the literature. (24616774)
2013
4
Severe hypoglycemia with "Big"-IGF-2 oversecretion by a giant phyllode tumor of the breast: a rare case of non-islet cell tumor-induced hypoglycemia (NICTH). (22867750)
2012
5
Spectrum of functioning islet cell tumor on multislice computed tomography: experience on 70 patients. (18437902)
2008
6
Generation and characterization of islet cell tumor in pTet-on/pTRE-SV40Tag double-transgenic mice model. (17697978)
2007
7
A minute nonfunctioning islet cell tumor demonstrating malignant features. (15754106)
2005
8
Surgical treatment of nonfunctioning islet cell tumor: report of 41 cases. (15313691)
2004
9
A wolf in sheep's clothing: a non-functioning islet cell tumor of the pancreas masquerading as a microcystic (serous cystic) adenoma. (15254352)
2004
10
Parathyroid hormone-related protein induced coupled increases in bone formation and resorption markers for 7 years in a patient with malignant islet cell tumors. (12009004)
2002
11
Antibodies directed against the E region of pro-insulin-like growth factor-II used to evaluate non-islet cell tumor-induced hypoglycemia. (12324491)
2002
12
Streptozocin for treatment of pancreatic islet cell tumors in dogs: 17 cases (1989-1999). (12322919)
2002
13
Malignant islet cell tumor of the pancreas associated with portal venous thrombus. (11511884)
2001
14
Immunocytochemical localization of prohormone convertase 1/3 and 2 in pancreatic islet cells and islet cell tumors. (11484919)
2001
15
Insulin and somatostatin releasing islet cell tumor caused hypoglycemia. (11334393)
2001
16
Functional pancreatic islet cell tumors with liver metastasis: the role of cytoreductive surgery and transcatheter arterial chemoembolization: a report of five cases. (9884450)
1998
17
Hepatoma with severe non-islet cell tumor hypoglycemia. (9647037)
1998
18
Fine-needle aspiration of pancreatic extramedullary plasmacytoma: possible confusion with islet cell tumor. (7924813)
1994
19
Aneuploid islet cell tumor with late metastasis. (7991294)
1994
20
Giant nonfunctioning islet cell tumor requiring pancreaticoduodenectomy and complete liver revascularization. (8101891)
1993
21
Duct-islet cell tumor of the pancreas. A case report with immunohistochemical and electron microscopic findings. (2558493)
1989
22
Islet cell tumor presenting as massive upper gastrointestinal bleeding in pregnancy. (2839980)
1988
23
Metastatic islet cell tumor with ACTH, gastrin, and glucagon secretion. Clinical and pathologic studies with multiple therapies. (3032401)
1987
24
Pancreatic islet cell tumors. (3029883)
1987
25
Insulin-producing islet cell tumor in an ectopic pancreas of a red fox (Vulpes vulpes). (6325727)
1984
26
Clonal analysis of insulin and somatostatin secretion and L-dopa decarboxylase expression by a rat islet cell tumor. (6129963)
1983
27
Metastasizing pancreatic islet cell tumors in the rat. (6279704)
1982
28
Rupture of a giant non-functioning pancreatic islet cell tumor following minimal trauma. (6258461)
1981
29
Glucagon secreting clones of rat islet cell tumor. (6257606)
1980
30
Serially transplantable chemically induced rat islet cell tumor. (6250800)
1980
31
Coexistence of bilateral pheochromocytoma and pancreatic islet cell tumor: report of a case and review of the literature. (215301)
1978
32
Remission of hypoglycemia after partial resection of a metastatic islet cell tumor. (208422)
1978
33
Vascular liver nodules caused by an islet cell tumor. (179758)
1976
34
Recent advances in management of functioning islet cell tumor. (4335281)
1972
35
Hydroxyindole-producing tumors of the pancreas. Carcinoid-islet cell tumor and oat cell carcinoma. (4340726)
1972
36
Islet cell tumor with hypoglycemia. (4323689)
1971
37
Adipose tissue lipolysis in golden hamsters with chronic hypoglycemia and hyperinsulinemia due to a transplantable islet cell tumor. (4329446)
1970
38
Pathogenesis of hypoglycemia in hamsters with a transplantable islet-cell tumor. (4303975)
1969
39
Prolonged remission of diarrhea due to nonbeta islet cell tumor of the pancreas by radiotherapy. (4296999)
1968
40
Giant nonfunctioning islet cell tumor. Survival after pancreaticoduodenectomy. (4296368)
1968
41
Functioning metastases from an islet cell tumor of the pancreas. (4289479)
1966
42
PEPTIC ULCER WITH ISLET CELL TUMOR: A REAPPRAISAL. (14215844)
1964
43
Islet cell tumor. Diarrhea, and hypopotassemia (the Zollinger-Ellison syndrome?). (13903135)
1962
44
The syndrome of refractory watery diarrhea and hypokalemia in patients with a non-insulin-secreting islet cell tumor. A further case study and review of the literature. (14476287)
1962
45
Pancreatic islet cell tumors and renal tumors in the male rat following neutron exposure. (14038763)
1961
46
Clinics on endocrine and metabolic diseases. 3. Hyperinsulinism: review of 95 cases of functioning pancreatic islet cell tumors. (13748469)
1960
47
Surgical treatment of the occult islet cell tumor. (13823626)
1959
48
Islet-cell tumor of the pancreas with hyperinsulinism; failure of surgical and alloxan treatment; report of a case. (13268201)
1955
49
Coma and hyperglycemia following islet-cell tumor removal. (14356522)
1955
50
Islet cell tumor of the pancreas: case report. (14838565)
1951

Variations for Islet Cell Tumor

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Expression for genes affiliated with Islet Cell Tumor

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Expression patterns in normal tissues for genes affiliated with Islet Cell Tumor

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Pathways for genes affiliated with Islet Cell Tumor

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Compounds for genes affiliated with Islet Cell Tumor

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Compounds related to Islet Cell Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 83)
idCompoundScoreTop Affiliating Genes
1111in-pentetreotide449.8CHGA, SST
25-hydroxytryptophan449.7CHGA, SST
3lanreotide44 2810.7SST, CHGA
4secretoneurin449.5CHGA, VIP
5tyr-3-octreotide449.5VIP, SST
6minigastrin449.5SST, VIP
7dacarbazine44 1110.5SST, CHGA
8streptozotocin449.5SST, CHGA, IAPP
9c-peptide449.5SST, CHGA, IAPP
10vanillylmandelic acid44 2410.5CHGA, VIP
11spantide449.5VIP, SST
12cyclophosphamide44 50 1111.2PTHLH, SST, CHGA
13catecholamine449.1CHGA, IAPP, VIP
14mibg449.1VIP, SST, CHGA
15oxyntomodulin44 6110.1VIP, CHGA, SST
165-hydroxyindoleacetic acid44 2410.1SST, CHGA, VIP
17propranolol44 28 50 24 1113.1CHGA, SST, VIP
18trifluoroethanol44 1110.0VIP, IAPP, PTHLH
19caffeine44 28 2 50 24 1114.0SST, CHGA, VIP
20carbachol44 28 1111.0CHGA, SST, VIP
215-hydroxytryptamine449.0VIP, SST, CHGA
22acth448.9SST, CHGA, VIP
23gnrh448.9VIP, CHGA, SST
24vitamin d448.9MEN1, PTHLH, CHGA
25gaba448.8SST, CHGA, VIP
26thyroxine44 249.8VIP, SST, PTHLH
27epinephrine44 24 1110.7SST, VIP, CHGA, IAPP
28histamine44 28 2410.7SST, IAPP, CHGA, VIP
29dopamine44 28 24 1111.6SST, VIP, IAPP, CHGA
30forskolin44 50 1110.6CHGA, IAPP, VIP, PTHLH
31ibmx44 61 2810.5PTHLH, VIP, SST, IAPP
32cyclic amp44 249.5PTHLH, VIP, CHGA, IAPP
33octreotide44 61 28 1111.5VIP, PTHLH, SST, CHGA
34nifedipine44 28 50 1111.5CHGA, PTHLH, VIP, SST
35thymidine44 249.5PTHLH, IAPP, MEN1, VIP
36nitric oxide44 24 1110.4PTHLH, VIP, CHGA, IAPP
37glucose448.4CHGA, PTHLH, IAPP, SST
38indomethacin44 28 61 1111.3PTHLH, IAPP, VIP
39estrogen448.1VIP, PTHLH, CHGA, MEN1
40isoproterenol44 119.1SST, VIP, CHGA, IAPP, PTHLH
41norepinephrine44 24 1110.1CHGA, SST, VIP, IAPP, PTHLH
42acetylcholine44 50 28 24 1112.1VIP, PTHLH, CHGA, SST, IAPP
43lactate448.1VIP, IAPP, SST, CHGA, PTHLH
44adenylate448.1IAPP, CHGA, PTHLH, VIP, SST
45testosterone44 61 24 1111.1PTHLH, SST, CHGA, IAPP, VIP
46dexamethasone44 50 28 1111.1VIP, PTHLH, CHGA, SST, IAPP
47arginine448.1CHGA, PTHLH, VIP, IAPP, SST
48serine448.0PTHLH, VIP, MEN1, IAPP, CHGA
49vegf447.9CHGA, SST, VIP, PTHLH, MEN1
50calcium44 50 24 1110.8MEN1, IAPP, VIP, PTHLH, CHGA

GO Terms for genes affiliated with Islet Cell Tumor

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Cellular components related to Islet Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:0430258.7SST, IAPP, VIP
2extracellular regionGO:0055767.3SST, IAPP, CHGA, VIP, PTHLH

Biological processes related to Islet Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1osteoblast developmentGO:0020769.3MEN1, PTHLH
2negative regulation of sequence-specific DNA binding transcription factor activityGO:0434339.3MEN1, PTHLH
3cell-cell signalingGO:0072678.8SST, IAPP, PTHLH
4negative regulation of cell proliferationGO:0082858.5PTHLH, SST, MEN1

Molecular functions related to Islet Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051798.1SST, IAPP, VIP, PTHLH

Products for genes affiliated with Islet Cell Tumor

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  • Antibodies
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Sources for Islet Cell Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet