Isolated Growth Hormone Deficiency disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Isolated Growth Hormone Deficiency

Sources:
²¹Genetics Home Reference, ³²MalaCards
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Genetics Home Reference:²¹ Isolated growth hormone deficiency is a condition caused by a severe shortage or absence of growth hormone. Growth hormone is a protein that is necessary for the normal growth of the body's bones and tissues. Because they do not have enough of this hormone, people with isolated growth hormone deficiency commonly experience a failure to grow at the expected rate and have unusually short stature. This condition is usually apparent by early childhood.

MalaCards: Isolated Growth Hormone Deficiency, also known as isolated somatotropin deficiency, is related to isolated growth hormone deficiency type 1b and hypoglycemia. An important gene associated with Isolated Growth Hormone Deficiency is GHRHR (growth hormone releasing hormone receptor), and among its related pathways are Primary immunodeficiency and Prolactin receptor signaling. The compounds estrogen and pirenzepine have been mentioned in the context of this disorder. Affiliated tissues include pituitary and bone, and related mouse phenotypes are adipose tissue and reproductive system.

Aliases & Classifications for Isolated Growth Hormone Deficiency

Sources:
²¹Genetics Home Reference, ⁶⁰UMLS, ⁴⁴Novoseek
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases

Aliases & Descriptions:

isolated growth hormone deficiency ²¹

isolated somatotropin deficiency ²¹ ⁶⁰

isolated somatotropin deficiency disorder ²¹

isolated human growth hormone deficiency ²¹

dwarfism, growth hormone deficiency ²¹

growth hormone deficiency dwarfism ²¹

isolated hgh deficiency ²¹

isolated gh deficiency ²¹

dwarfism, pituitary ²¹

dwarfism pituitary ⁴⁴

pituitary dwarfism ⁶⁰

Related Diseases for Isolated Growth Hormone Deficiency

Sources:
¹⁷GeneCards, ¹⁸GeneDecks
See all sources

Diseases related to Isolated Growth Hormone Deficiency via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 130)

id	Related Disease	Score	Top Affiliating Genes
1	isolated growth hormone deficiency type 1b	30.8	GHRHR, GH1
2	hypoglycemia	30.6	IGF1, GH1, GHRH, POMC
3	agammaglobulinemia	30.6	CD40LG, BTK, CD79A
4	dwarfism	30.5	GHRH, GHRHR, IGF1, POU1F1, GH1
5	laron syndrome	30.4	GH1, IGF1
6	thyroiditis	30.4	POMC, CD79A
7	acromegaly	30.2	GH1, IGF1
8	hyperprolactinemia	30.2	IGF1, GH1, GHRH, POMC
9	hypogonadism	30.2	GH1, IGF1, POU1F1, POMC
10	anorexia nervosa	30.2	GHRH, GH1, IGF1, POMC
11	pituitary hypoplasia	30.2	OTX2, POU1F1, GHRH, LHX4, HESX1, SOX3
12	obesity	30.2	GHSR, POMC, GHRH, HESX1, GH1, IGF1
13	panhypopituitarism	30.2	IGF1, LHX4, POU1F1, POMC, GH1, HESX1
14	hypopituitarism	30.2	HESX1, POMC, POU1F1, IGF1, GH1, GHRH
15	turner syndrome	29.9	IGF1
16	diabetes insipidus	29.9	POMC, GHRH
17	amenorrhea	29.9	IGF1, POMC
18	hypothyroidism	29.9	GH1, POMC, POU1F1, GHRH, GHSR, IGF1
19	mental retardation, x-linked, with isolated growth hormone deficiency	10.6
20	isolated growth hormone deficiency type 2	10.6
21	isolated growth hormone deficiency type 3	10.5
22	isolated gonadotropin-releasing hormone deficiency	10.5
23	isolated growth hormone deficiency type 1a	10.5
24	isolated growth hormone deficiency, type ib, ghrhr-related	10.3
25	partial isolated growth hormone deficiency	10.3
26	isolated growth hormone deficiency, type ib, gh1-related	10.3
27	isolated growth hormone deficiency due to defect in ghrf	10.3
28	leukemia	10.2
29	autosomal dominant chondrodysplasia punctata	10.2
30	deficiency anemia	10.1
31	cystic fibrosis	10.1
32	fanconi's anemia	10.1
33	mulibrey nanism	10.1
34	meningoencephalitis	10.1
35	complement deficiency	10.1
36	dermatomyositis	10.1
37	x-linked disease	10.1
38	mental retardation, x-linked, with growth hormone deficiency	10.1
39	agammaglobulinemia and isolated hormone deficiency	10.1
40	acute leukemia	10.1
41	pituitary dwarfism with large sella turcica	10.1
42	short bowel syndrome	10.0	GH1
43	gastrinoma	10.0	GH1
44	liver cirrhosis	10.0	GHRH
45	adenocarcinoma	10.0	POU1F1
46	optic nerve hypoplasia	10.0	PAX6
47	rabson-mendenhall syndrome	10.0	IGF1
48	rheumatic fever	10.0	POMC
49	mental retardation	10.0	PAX6, SOX3
50	gigantism	10.0	GH1, IGF1

Graphical network of the top 20 diseases related to Isolated Growth Hormone Deficiency:

Clinical Features for Isolated Growth Hormone Deficiency

Drugs & Therapeutics for Isolated Growth Hormone Deficiency

Sources:
⁵CenterWatch, ⁴¹NIH Clinical Center, ⁶ClinicalTrials, ⁶⁰UMLS, ⁴⁰NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Isolated Growth Hormone Deficiency

Drug clinical trials:

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Search NIH Clinical Center for Isolated Growth Hormone Deficiency

Search CenterWatch for Isolated Growth Hormone Deficiency

Genetic Tests for Isolated Growth Hormone Deficiency

Anatomical Context for Isolated Growth Hormone Deficiency

Sources:
³²MalaCards
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MalaCards organs/tissues related to Isolated Growth Hormone Deficiency:

³²

Pituitary, Bone

Animal Models for Isolated Growth Hormone Deficiency or affiliated genes

Sources:
³⁶MGI
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MGI Mouse Phenotypes related to Isolated Growth Hormone Deficiency:

³⁶ (show all 11)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	adipose tissue phenotype	MP:0005375	9.2	POMC, IGF1, GH1, GHSR, GHRHR
2	reproductive system phenotype	MP:0005389	8.2	SOX3, GHRHR, GHRH, GH1, IGF1, POU1F1
3	skeleton phenotype	MP:0005390	8.0	GHSR, PAX6, SLC20A1, CD40LG, IGF1, GHRHR
4	integument phenotype	MP:0010771	7.7	SLC20A1, PAX6, CD40LG, BTK, POMC, IGF1
5	endocrine/exocrine gland phenotype	MP:0005379	7.4	GHRHR, IGF1, SOX3, LHX4, PAX6, CD40LG
6	growth/size phenotype	MP:0005378	7.3	IGF1, GH1, POU1F1, POMC, BTK, SLC20A1
7	immune system phenotype	MP:0005387	7.2	PAX6, SLC20A1, CD79A, CD40LG, BTK, POMC
8	cellular phenotype	MP:0005384	7.1	CD79A, SLC20A1, OTX2, PAX6, CD40LG, BTK
9	mortality/aging	MP:0010768	7.0	CD40LG, SLC20A1, IGF1, OTX2, PAX6, BTK
10	nervous system phenotype	MP:0003631	6.9	GHRHR, GHRH, GH1, CD40LG, POU1F1, POMC
11	homeostasis/metabolism phenotype	MP:0005376	6.1	POU1F1, IGF1, GH1, GHRH, POMC, BTK

Publications for Isolated Growth Hormone Deficiency

Genes related to Isolated Growth Hormone Deficiency

Sources:
¹⁷GeneCards, ⁴⁵Novus Biologicals, ³¹LifeSpan BioSciences, Inc.
See all sources

Genes related to Isolated Growth Hormone Deficiency:

(show all 21)

id	Symbol	Description	Score	Implication
1	GHRHR	growth hormone releasing hormone receptor	20.59	GeneCards inferred : Publications, Disorders, Summaries (show sections)
2	SOX3	SRY (sex determining region Y)-box 3	19.60	GeneCards inferred : Disorders (show sections)
3	GH1	growth hormone 1	18.64	GeneCards inferred : Publications, Disorders (show sections)
4	GHSR	growth hormone secretagogue receptor	17.68	GeneCards inferred : Publications, Disorders (show sections)
5	BTK	Bruton agammaglobulinemia tyrosine kinase	16.72	GeneCards inferred : Publications, Disorders (show sections)
6	HESX1	HESX homeobox 1	15.75	GeneCards inferred : Publications, Disorders (show sections)
7	GHRH	growth hormone releasing hormone	14.80	GeneCards inferred : Publications, Disorders (show sections)
8	GH2	growth hormone 2	13.84	GeneCards inferred : Publications, Disorders (show sections)
9	OTX2	orthodenticle homeobox 2	12.89	GeneCards inferred : Publications, Disorders (show sections)
10	POU1F1	POU class 1 homeobox 1	11.94	GeneCards inferred : Publications, Disorders (show sections)
11	CSH1	chorionic somatomammotropin hormone 1 (placental lactogen)	10.99	GeneCards inferred : Publications, Disorders (show sections)
12	LHX4	LIM homeobox 4	10.03	GeneCards inferred : Publications, Disorders (show sections)
13	PAX6	paired box 6	9.08	GeneCards inferred : Publications, Disorders (show sections)
14	IGF1	insulin-like growth factor 1 (somatomedin C)	8.13	GeneCards inferred : Publications, Disorders (show sections)
15	POMC	proopiomelanocortin	7.18	GeneCards inferred : Publications, Disorders (show sections)
16	CD40LG	CD40 ligand	6.22	GeneCards inferred : Publications, Disorders (show sections)
17	CD79A	CD79a molecule, immunoglobulin-associated alpha	5.27	GeneCards inferred : Publications, Disorders (show sections)
18	CSHL1	chorionic somatomammotropin hormone-like 1	4.32	GeneCards inferred : Publications, Disorders (show sections)
19	SLC20A1	solute carrier family 20 (phosphate transporter), member 1	3.37	GeneCards inferred : Publications, Disorders (show sections)
20	ITGBL1	integrin, beta-like 1 (with EGF-like repeat domains)	2.42	GeneCards inferred : Publications, Disorders (show sections)
21	GHR	growth hormone receptor	0.89	GeneCards inferred : Publications (show sections)

Products for genes related to Isolated Growth Hormone Deficiency disease:

id	Company	Proteins	Lysates	Antibodies
1	Novus Biologicals	21	21	21
2	LSBio	-	-	21

Genetic Variations for Isolated Growth Hormone Deficiency

Expression for genes affiliated with Isolated Growth Hormone Deficiency

Sources:
¹BioGPS, ¹⁵Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with Isolated Growth Hormone Deficiency

Search GEO for disease gene expression data for Isolated Growth Hormone Deficiency.

Pathways for genes affiliated with Isolated Growth Hormone Deficiency

Sources:
²⁹KEGG, ⁵³Reactome, ¹²EMD Millipore, ⁵¹QIAGEN, ³⁷NCBI BioSystems Database
See all sources

Pathways related to Isolated Growth Hormone Deficiency according to GeneCards/GeneDecks:

(show all 16)

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Primary immunodeficiency²⁹	9.8	CD79A, BTK
2	Prolactin receptor signaling⁵³ Hide members Growth hormone receptor signaling⁵³ Nuclear signaling by ERBB4⁵³	9.8	CSH1, GH2, GH1
3	Transcription factors in neurogenesis¹²	9.7	SOX3, PAX6, OTX2
4	NF-KappaB Family Pathway⁵¹ Hide members NF-KappaB (p50-p65) Pathway⁵¹	9.5	GHRH, IGF1, GH2, GH1
5	TGF-Beta Pathway⁵¹ Hide members SOCS Pathway⁵¹ JAK-STAT Pathway⁵¹ Regulation of eIF4 and p70S6K⁵¹ JNK Pathway⁵¹ MAPK Family Pathway⁵¹	9.3	GHRH, GH2, GH1, IGF1, BTK
6	PAK Pathway⁵¹ Hide members Antioxidant Action of Vitamin-C⁵¹ Epithelial Adherens Junctions⁵¹	9.3	BTK, GHRH, GH2, GH1, IGF1
7	Akt Signaling⁵¹ Hide members p38 Signaling⁵¹ Tec Kinases Signaling⁵¹	9.3	IGF1, GH2, GH1, BTK, GHRH
8	G-Beta Gamma Signaling⁵¹ Hide members CRHR Pathway⁵¹ GHRH Signaling⁵¹	9.0	GHRH, GHRHR, GH2, GH1, POMC, BTK
9	ErbB4 Pathway⁵¹ Hide members PI3K Signaling in B-Lymphocyte⁵¹ Growth Hormone Signaling⁵¹	9.0	GH1, GH2, CD79A, BTK, IGF1
10	GPCR Pathway⁵¹ Hide members NFAT in Immune Response⁵¹ Pancreatic Adenocarcinoma⁵¹ Ras Pathway⁵¹ Paxillin Interactions⁵¹ Breast Cancer Regulation by Stathmin1⁵¹ Estrogen Pathway⁵¹	8.8	GH2, CD79A, GH1, IGF1, BTK, GHRH
11	PTEN Pathway⁵¹ Hide members Phospholipase-C Pathway⁵¹	8.8	GH1, IGF1, BTK, GHRH, CD79A, GH2
12	CREB Pathway⁵¹ Hide members IP3 Pathway⁵¹ Intracellular Calcium Signaling⁵¹ Activation of PKC through GPCR⁵¹	8.8	BTK, CD79A, IGF1, GHRH, GH1, GH2
13	Class A/1 (Rhodopsin-like receptors)⁵³ Hide members GPCR ligand binding⁵³ G alpha (i) signalling events⁵³ Peptide ligand-binding receptors⁵³ Neuroactive ligand-receptor interaction²⁹ GPCRs, Class A Rhodopsin-like³⁷	8.8	GH1, POMC, GH2, GHRH, GHSR, GHRHR
14	Rho Family GTPases⁵¹ Hide members ERK Signaling⁵¹ Molecular Mechanisms of Cancer⁵¹ ILK Signaling⁵¹ MAPK Signaling⁵¹	8.7	GH2, PAX6, BTK, IGF1, GH1, GHRH
15	Immune System⁵³ Hide members Adaptive Immune System⁵³ Innate Immune System⁵³	8.7	CD79A, CSH1, GH2, GH1, BTK, CD40LG
16	Signaling by GPCR⁵³ Hide members GPCR downstream signaling⁵³ Signal Transduction⁵³	8.4	CSH1, GHRHR, GHSR, GHRH, GH2, GH1

Compounds for genes affiliated with Isolated Growth Hormone Deficiency

Sources:
⁴⁴Novoseek, ²⁸IUPHAR, ¹¹DrugBank, ²⁴HMDB, ⁴⁹PharmGKB, ²BitterDB, ⁵⁹Tocris Bioscience
See all sources

Compounds related to Isolated Growth Hormone Deficiency according to GeneCards/GeneDecks:

(show top 50) (show all 69)

id	Compound	Score	Top Affiliating Genes
1	estrogen⁴⁴	10.4	CD79A
2	pirenzepine⁴⁴ ²⁸ ¹¹	12.4	GH1, GHRH
3	mk-0677⁴⁴ ²⁸	11.3	GHSR, IGF1
4	somatuline⁴⁴	10.2	GH1, IGF1
5	hcrh⁴⁴	10.2	GHSR, POMC
6	norepinephrine⁴⁴ ¹¹ ²⁴	12.2	POMC, GHRH
7	quinagolide⁴⁴	10.2	GH1, IGF1
8	pyridostigmine⁴⁴ ¹¹	11.1	GHRH, GH1, IGF1
9	pegvisomant⁴⁴ ¹¹	11.1	IGF1, GH1, GHRH
10	acipimox⁴⁴ ²⁸	11.1	IGF1, GH1, GHRH
11	dehydroepiandrosterone sulfate⁴⁴	10.1	GH1, POMC
12	bromocriptine²⁸ ⁴⁴ ¹¹	12.0	GHRH, POU1F1, POMC
13	sulfolipid i⁴⁴	10.0	CD40LG, CD79A
14	oxandrolone⁴⁴ ¹¹	10.9	IGF1, GH1
15	lanreotide⁴⁴ ²⁸	10.9	GHSR, GHRH, GH1, IGF1
16	cortisone⁴⁴ ²⁴	10.9	POMC, IGF1, GH1
17	sandoglobulin⁴⁴	9.9	CD40LG, CD79A
18	clomiphene citrate⁴⁴	9.9	GH1, IGF1, CD40LG
19	naloxone⁴⁴ ⁴⁹ ²⁸ ¹¹	12.9	POMC, GH1, GHRH
20	salbutamol⁴⁴ ⁴⁹ ²⁸ ¹¹ ²⁴	13.9	CD79A, GH1, GHRH
21	ghrp⁴⁴	9.8	GHRHR, GHSR, GHRH, GH1, IGF1
22	naltrexone⁴⁴ ⁴⁹ ²⁸ ¹¹	12.8	GHRH, GH1, IGF1, POMC
23	clonidine⁴⁴ ²⁸ ¹¹	11.8	GHRH, GH1, IGF1, POMC
24	triiodothyronine⁴⁴	9.7	GHRH, GH1, IGF1, POMC
25	hydrocortisone⁴⁴ ² ⁵⁹ ¹¹	12.7	GHSR, GH1, IGF1, POMC
26	forskolin⁴⁴ ⁴⁹ ¹¹	11.6	GHRHR, GHSR, GHRH, POU1F1, POMC
27	octreotide⁴⁴ ⁵⁹ ²⁸ ¹¹	12.6	POMC, IGF1, GH1, GHRH, GHSR
28	ivig⁴⁴	9.5	CD79A, CD40LG, BTK
29	gnrh⁴⁴	9.5	HESX1, GHRH, GH1, IGF1, POMC
30	valproate⁴⁴	9.5	IGF1, CD40LG, CD79A
31	metformin⁴⁴ ⁴⁹ ¹¹	11.5	GH1, IGF1, POMC
32	hexarelin⁴⁴ ²⁸	10.4	POMC, IGF1, GH1, GHRH, GHSR, GHRHR
33	estradiol⁴⁴ ¹¹ ²⁴	11.4	GHSR, GHRH, GH1, IGF1, POMC
34	vitamin d⁴⁴	9.3	CD79A, POU1F1, IGF1, GH1, GHRH
35	adenylate⁴⁴	9.2	GHRHR, GHSR, GHRH, GH1, POMC, CD40LG
36	acth⁴⁴	9.1	HESX1, GHSR, GHRH, GH1, IGF1, POU1F1
37	vitamin b12⁴⁴	9.0	CD79A, CD40LG, IGF1
38	thyroxine⁴⁴ ²⁴	9.9	GHRH, GH1, IGF1, POMC, CD40LG, CD79A
39	ribonucleic acid⁴⁴	8.9	GHRHR, GHSR, GHRH, GH2, GH1, IGF1
40	steroid⁴⁴	8.8	GHSR, GHRH, GH1, IGF1, POU1F1, POMC
41	glucose⁴⁴	8.8	GHRHR, GHSR, GHRH, GH2, GH1, IGF1
42	creatinine⁴⁴	8.7	CD79A, CD40LG, POMC, IGF1, GH1
43	glutamate⁴⁴	8.7	GHRHR, GHRH, POU1F1, CD40LG, CD79A, PAX6
44	alanine⁴⁴	8.6	SOX3, GH1, POU1F1, POMC, CD40LG, CD79A
45	vegf⁴⁴	8.5	GH1, IGF1, POMC, CD40LG, CD79A, PAX6
46	serine⁴⁴	8.4	GHSR, GHRH, GH1, IGF1, POMC, BTK
47	testosterone⁴⁴ ⁵⁹ ¹¹ ²⁴	11.4	GHSR, GHRH, GH2, GH1, IGF1, POMC
48	dopamine⁴⁴ ²⁸ ¹¹ ²⁴	11.4	GHSR, GHRH, GH1, IGF1, POU1F1, POMC
49	dexamethasone⁴⁴ ⁴⁹ ²⁸ ¹¹	11.3	GHRHR, GHSR, GHRH, GH1, IGF1, POU1F1
50	arginine⁴⁴	7.1	IGF1, GH1, GHRH, GHSR, GHRHR, POU1F1

GO Terms for genes affiliated with Isolated Growth Hormone Deficiency

Sources:
¹⁶Gene Ontology
See all sources

Cellular components related to Isolated Growth Hormone Deficiency according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:005576	7.5	POMC, IGF1, GH1, GH2, GHRH, ITGBL1

Biological processes related to Isolated Growth Hormone Deficiency according to GeneCards/GeneDecks:

(show all 14)

id	Name	GO ID	Score	Top Affiliating Genes
1	somatotropin secreting cell development	GO:060133	10.3	POU1F1, GHRHR
2	positive regulation of growth hormone secretion	GO:060124	10.2	GHRH, GHRHR
3	response to food	GO:032094	10.2	GHRH, GHSR
4	water homeostasis	GO:030104	10.2	GHRHR, IGF1
5	growth hormone secretion	GO:030252	10.1	GHRH, GHSR, GHRHR
6	determination of adult lifespan	GO:008340	10.0	POU1F1, GHRHR
7	JAK-STAT cascade involved in growth hormone signaling pathway	GO:060397	10.0	CSH1, GH2, GH1
8	positive regulation of tyrosine phosphorylation of Stat5 protein	GO:042523	9.9	IGF1, GH1
9	organ morphogenesis	GO:009887	9.7	LHX4, SOX3, PAX6
10	positive regulation of multicellular organism growth	GO:040018	9.7	GHRHR, GHSR, GHRH, GH1, POU1F1
11	cell fate specification	GO:001708	9.7	OTX2, POU1F1
12	positive regulation of insulin-like growth factor receptor signaling pathway	GO:043568	9.6	IGF1, GH1, GHRH, GHSR, GHRHR
13	B cell differentiation	GO:030183	9.5	CD79A, CD40LG, POU1F1
14	B cell proliferation	GO:042100	9.5	CD79A, CD40LG

Molecular functions related to Isolated Growth Hormone Deficiency according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	growth hormone-releasing hormone receptor activity	GO:016520	10.1	GHSR, GHRHR
2	hormone activity	GO:005179	8.2	POMC, IGF1, GH1, GH2, CSH1, CSHL1

Products for genes affiliated with Isolated Growth Hormone Deficiency

Antibodies
Proteins
Lysates

Antibodies

Sources for Isolated Growth Hormone Deficiency

¹BioGPS

²BitterDB

³CDC

⁴Cell Signaling Technology

⁵CenterWatch

⁶ClinicalTrials

⁷dbSNP

⁸Disease Ontology

⁹diseasecard

¹⁰DISEASES

¹¹DrugBank

¹²EMD Millipore

¹³ExPASy

¹⁴FMA

¹⁵Gene Expression Omnibus DataSets

¹⁶Gene Ontology

¹⁷GeneCards

¹⁸GeneDecks

¹⁹GeneReviews

²⁰GeneTests

²¹Genetics Home Reference

²²GTR

²³HGMD

²⁴HMDB

²⁵ICD10

²⁶ICD10 via Orphanet

²⁷ICD9CM

²⁸IUPHAR

²⁹KEGG

³⁰LifeMap Discovery™

³¹LifeSpan BioSciences, Inc.

³²MalaCards

³³MedlinePlus

³⁴MeSH

³⁵MESH via Orphanet

³⁶MGI

³⁷NCBI BioSystems Database

³⁸NCBI Bookshelf

³⁹NCIt

⁴⁰NDF-RT

⁴¹NIH Clinical Center

⁴²NIH Rare Diseases

⁴³NINDS

⁴⁴Novoseek

⁴⁵Novus Biologicals

⁴⁶OMIM

⁴⁷OMIM via Orphanet

⁴⁸Orphanet

⁴⁹PharmGKB

⁵⁰PubMed

⁵¹QIAGEN

⁵²R&D Systems

⁵³Reactome

⁵⁴SABiosciences

⁵⁵SinoBiological

⁵⁶SNOMED-CT

⁵⁷SNOMED-CT via Orphanet

⁵⁸Thomson Reuters

⁵⁹Tocris Bioscience

⁶⁰UMLS

⁶¹UMLS via Orphanet

⁶²UniProtKB/Swiss-Prot

⁶³Wikipedia

MCID: ISL003 MIFTS: 39	Isolated Growth Hormone Deficiency malady Endocrine diseases category
21 genes, 2 tissues, 130 related diseases, clinical trials.

Isolated Growth Hormone Deficiency malady