Isolated Growth Hormone Deficiency malady

Genetics Home Reference: Isolated growth hormone deficiency is a condition caused by a severe shortage or absence of growth hormone. Growth hormone is a protein that is necessary for the normal growth of the body's bones and tissues. Because they do not have enough of this hormone, people with isolated growth hormone deficiency commonly experience a failure to grow at the expected rate and have unusually short stature. This condition is usually apparent by early childhood.¹⁷

MalaCards: Isolated Growth Hormone Deficiency, also known as dwarfism, growth hormone deficiency, is related to isolated growth hormone deficiency, type ia and isolated growth hormone deficiency, type ib. An important gene associated with Isolated Growth Hormone Deficiency is GHRHR (growth hormone releasing hormone receptor), and among its related pathways are Ras Pathway and Growth Hormone Signaling. The compounds ivig and somatuline have been mentioned in the context of this disorder. Affiliated tissues include t cells and pituitary, and related mouse phenotypes are skeleton and adipose tissue.

isolated growth hormone deficiency 7 17 dwarfism, growth hormone deficiency 17 growth hormone deficiency dwarfism 17 isolated somatotropin deficiency 43

dwarfism, pituitary 17 pituitary dwarfism 43 dwarfism pituitary 32

Disease types for isolated growth hormone deficiency family:

xla and isolated growth hormone deficiency	isolated growth hormone deficiency type 1a
isolated growth hormone deficiency type 1b	isolated growth hormone deficiency type 2
isolated growth hormone deficiency type 3	isolated growth hormone deficiency, type ia
isolated growth hormone deficiency, type ib

Diseases related to isolated growth hormone deficiency by text searches and GeneDecks gene sharing:

(show top 50)    (show all 187)

id	Related Disease	Score	Top Affiliating Genes
1	isolated growth hormone deficiency, type ia	33.1	IGF1, CSH1, CSHL1
2	isolated growth hormone deficiency, type ib	32.8	GH1, GHRHR
3	growth hormone deficient dwarfism	30.8	GH1, POU1F1
4	dwarfism	29.9	POU1F1, GHRHR, GHRH, GH1, IGF1
5	laron syndrome	29.8	GH1, IGF1
6	agammaglobulinemia	28.8	BTK, CD79A, CD40LG
7	growth hormone deficiency	28.5	BTK, OTX2, HESX1, SOX3, CSH1, CSHL1
8	anophthalmia	28.4	POU1F1, SOX3, HESX1, OTX2, LHX4, PAX6
9	short stature	27.2	POU1F1, CSH1, SOX3, HESX1, GHSR, GHRHR
10	turner syndrome	26.5	POMC, GH1, IGF1, CD40LG, CD79A
11	thyroiditis	24.0	POU1F1, POMC, CSH1, OTX2, GHSR, GH2
12	laron dwarfism	13.4	GH1, IGF1
13	pituitary gland disease	13.4	GH1, IGF1
14	insulin-like growth factor i deficiency	13.4	GH1, IGF1
15	insulin-like growth factor 1 resistance to	13.4	GH1, IGF1
16	pseudohypoparathyroidism type ia	13.4	GH1, IGF1
17	robinow syndrome	13.4	GH1, IGF1
18	rabson-mendenhall syndrome	13.4	GH1, IGF1
19	fetal adenoma	13.4	GHRH, GH1
20	idiopathic juvenile osteoporosis	13.3	GH1, IGF1
21	mitochondrial encephalomyopathy lactic acidosis and stroke-like episodes	13.3	GHRH, GH1
22	growth disorders	13.2	IGF1, GH1, GHRH
23	pancreatic islet cell tumors	13.2	POU1F1, GHRHR, GHRH
24	pseudohypoparathyroidism	13.2	IGF1, GH1, GHRH
25	optic nerve hypoplasia	13.2	HESX1, PAX6
26	adrenocorticotropic hormone deficiency	13.2	POMC, GHRH
27	lymphocytic hypophysitis	13.2	IGF1, POMC
28	pituitary-dependent cushing's disease	13.1	POMC, GH1
29	paralytic poliomyelitis	13.1	CD40LG, BTK
30	empty sella syndrome	13.1	POU1F1, GH1, IGF1
31	sheehan syndrome	13.1	POMC, IGF1
32	growth retardation with deafness and mental retardation due to igf1 deficiency	13.1	GHRH, GH1, IGF1
33	septooptic dysplasia	13.1	POU1F1, HESX1, GH1
34	cushing's syndrome	13.1	POMC, GH1
35	pituitary apoplexy	13.1	POMC, GH1
36	somatotrophinoma	13.1	GHRHR, GHRH, GH1, IGF1
37	placental site trophoblastic tumor	13.0	CSHL1, CSH1, GH2, GH1
38	hypoadrenalism	13.0	POMC, GH1
39	acid-labile subunit	13.0	GH1, IGF1
40	cataract-glaucoma	13.0	PAX6, OTX2
41	gonadal disease	13.0	IGF1, GH1, POMC
42	petrositis	12.9	POMC, GH1, IGF1
43	adrenal gland hyperfunction	12.9	POMC, GHRH, GH1
44	familial male-limited precocious puberty	12.9	IGF1, GH1, POMC
45	21-hydroxylase deficiency	12.9	GH1, GHRH, POMC
46	functioning pituitary adenoma	12.9	IGF1, GH1, POMC
47	gastrinoma	12.9	POMC, GH1, IGF1
48	mitochondrial encephalomyopathy	12.9	POMC, GHRH, GH1
49	borjeson-forssman-lehmann syndrome	12.9	POU1F1, SOX3, HESX1, LHX4
50	diabetes insipidus	12.9	POMC, GHRH, IGF1

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to isolated growth hormone deficiency:

²²

MGI Mouse Phenotypes related to isolated growth hormone deficiency:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	skeleton phenotype	MP:0005390	9.2	OTX2, GHSR, GHRHR, IGF1
2	adipose tissue phenotype	MP:0005375	8.5	IGF1, GH1, GHRHR, GHSR, POMC
3	integument phenotype	MP:0010771	8.3	SLC20A1, POMC, GHRHR, PAX6, BTK
4	reproductive system phenotype	MP:0005389	7.3	POU1F1, SOX3, OTX2, GHRHR, GHRH, GH1
5	growth/size phenotype	MP:0005378	6.5	PAX6, IGF1, GH1, GHRH, GHRHR, GHSR
6	mortality/aging	MP:0010768	6.2	IGF1, LHX4, PAX6, BTK, OTX2, HESX1
7	endocrine/exocrine gland phenotype	MP:0005379	6.2	PAX6, POU1F1, POMC, SOX3, HESX1, IGF1
8	nervous system phenotype	MP:0003631	5.6	POU1F1, CD79A, PAX6, LHX4, CD40LG, HESX1
9	homeostasis/metabolism phenotype	MP:0005376	4.8	GH1, IGF1, CD40LG, CD79A, LHX4, GHRH

Articles related to isolated growth hormone deficiency:

(show all 41)

id	Title	Authors	Year	Affiliating Genes
1	Genetic polymorphisms in the locus control region and promoter of GH1 are related to serum IGF-I levels and height in patients with isolated growth hormone deficiency and healthy controls. (20190537)	de Graaff L.C.... Hokken-Koelega A.C.	2010	IGF1, GH1
2	A novel loss-of-function mutation in OTX2 in a patien t with anophthalmia and isolated growth hormone deficiency. (20396904)	Ashkenazi-Hoffnung L.... Gat-Yablonski G.	2010	OTX2, LHX4, HESX1
3	Genetics of isolated growth hormone deficiency. (21274339)	Mullis P.E.	2010	IGF1, GH1, GHRH
4	Isolated growth hormone deficiency in a patient with immunoglobulin class switch recombination deficiency. (19610268)	Kashef S.... Hammarstrom L.	2009	CD40LG, CD79A
5	Recessive isolated growth hormone deficiency and muta tions in the ghrelin receptor. (19789204)	Pantel J.... Amselem S.	2009	GHSR
6	A recurrent signal peptide mutation in the growth hor mone releasing hormone receptor with defective translocation to the cell surfac e and isolated growth hormone deficiency. (19622623)	Godi M.... Giordano M.	2009	GHRHR, GHRH
7	A molecular basis for variation in clinical severity of isolated growth hormone deficiency type II. (19837935)	Hamid R.... Patton J.G.	2009	GH1
8	Isolated growth hormone deficiency type II caused by a point mutation that alters both splice site strength and splicing enhancer function. (18554279)	Shariat N.... Patton J.G.	2008	GH1
9	A functional common polymorphism in the vitamin D-responsive element of the GH1 promoter contributes to isolated growth hormone deficiency. (18160466)	Giordano M.... Momigliano-Richiardi P.	2008	GH1
10	Genetic screening of a Dutch population with isolated growth hormone deficiency. (18785993)	de Graaff L.C.... Hokken-Koelega A.C.	2008	GH1, GHRHR
11	Absence of mutations in Pax6 gene in three cases of morning glory syndrome associated with isolated growth hormone deficiency. (19169473)	Guerra-Junior G.... Mello M.P.	2008	PAX6
12	Mutant and misfolded human growth hormone is rapidly degraded through the proteasomal degradation pathway in a cellular model for isolated growth hormone deficiency type II. (17927666)	Kannenberg K.... Binder G.	2007	GH1
13	Isolated growth hormone deficiency. (17965963)	HernA!ndez L.M.... Camacho-HA1bner C.	2007	GH1
14	Variable phenotypes in familial isolated growth hormone deficiency caused by a G6664A mutation in the GH-1 gene. (17785368)	Hess O.... Tenenbaum-Rakover Y.	2007	GH1
15	A case with isolated growth hormone deficiency caused by compound heterozygous mutations in GH-1: a novel missense mutation in the initiation codon and a 7.6kb deletion. (17360216)	Hayashi Y.... Seo H.	2007	GH1
16	Foot length before and during insulin-like growth factor-I treatment of children with laron syndrome compared to human growth hormone treatment of children with isolated growth hormone deficiency. (18341092)	Silbergeld A.... Laron Z.	2007	IGF1, GH1
17	Autosomal-dominant isolated growth hormone deficiency (IGHD type II) with normal GH-1 gene. (16424673)	Fintini D.... Mullis P.E.	2006	GH1, HESX1
18	A novel splicing mutation in exon 4 (456G>A) of the GH1 gene in a patient with congenital isolated growth hormone deficiency. (17178704)	Fofanova O.V.... Dedov I.I.	2006	GH1
19	GH-1 gene splicing mutations: molecular basis of hereditary isolated growth hormone deficiency in children. (17073157)	Fofanova O.V.... Dedov I.I.	2006	GH1
20	A novel deletion in the GH1 gene including the IVS3 branch site responsible for autosomal dominant isolated growth hormone deficiency. (16368751)	Vivenza D.... Giordano M.	2006	GH1
21	Growth hormone releasing hormone receptor (GHRH-r) gene mutation in Indian children with familial isolated growth hormone deficiency: a study from western India. (16355809)	Desai M.P.... Nair S.R.	2005	GHRHR
22	A nonsense mutation (E72X) in growth hormone releasing hormone receptor (GHRHR) gene is the major cause of familial isolated growth hormone deficiency in Western region of India: founder effect suggested by analysis of dinucleotide repeat polymorphism close to GHRHR gene. (15336233)	Kamijo T.... Desai M.P.	2004	GHRHR
23	Isolated growth hormone deficiency in Chilean patients: clinical and molecular analysis. (14594175)	Molina G.... Carvallo P.	2003	GHSR, GH1, GHRH
24	A novel IVS2 -2A>T splicing mutation in the GH-1 gene in familial isolated growth hormone deficiency type II in the spectrum of other splicing mutations in the Russian population. (12574219)	Fofanova O.V.... Dedov I.I.	2003	GH1
25	Isolated growth hormone deficiency and the GH-1 gene: update 2002. (12435888)	Binder G.	2002	GH1, POU1F1
26	New GH-1 gene mutations: expanding the spectrum of causes of isolated growth hormone deficiency. (12510984)	Mullis P.E.... Dannies P.S.	2002	GH1
27	An exonic mutation of the GH-1 gene causing familial isolated growth hormone deficiency type II. (12000366)	Takahashi I.... Takada G.	2002	GH1
28	A novel and de novo splice-donor site mutation in intron 3 of the GH-1 gene in a patient with isolated growth hormone deficiency. (11914025)	Katsumata N.... Tanaka T.	2001	GH1
29	Isolated growth hormone deficiency in children and adolescents. (11529396)	Argente J.... Skordis N.	2001	SLC20A1
30	Prevalence of GH-1 gene deletion in patients with isolated growth hormone deficiency in Japan. GH Gene Study Group. (10943739)	Ogawa M.... Byun Y.J.	2000	GH1
31	Short stature in carriers of recessive mutation causing familial isolated growth hormone deficiency. (10678654)	Leiberman E.... Carmi R.	2000	GH1
32	Hereditary isolated growth hormone deficiency caused by GH1 gene mutations in Japanese patients. (10549303)	Kamijo T.... Ogawa M.	1999	GH1
33	Isolated growth hormone deficiency: testing the little mouse hypothesis in man and exclusion of mutations within the extracellular domain of the growth hormone-releasing hormone receptor. (8618801)	Cao Y.... Mullis P.E.	1995	IGF1, GHRHR
34	Molecular study of human growth hormone gene cluster in three families with isolated growth hormone deficiency and similar phenotype. (7957420)	Cacciari E.... Cicognani A.	1994	GH1, GH2
35	Isolated growth hormone deficiency type IA associated with a 45-kilobase gene deletion within the human growth hormone gene cluster in an Italian family. (7877887)	Ghizzoni L.... Bernasconi S.	1994	CSH1, CSHL1
36	An exon-skipping mutation in the btk gene of a patient with X-linked agammaglobulinemia and isolated growth hormone deficiency. (8013627)	Duriez B.... Goossens M.	1994	BTK
37	Genetic and molecular analysis of familial isolated growth hormone deficiency. (8104861)	Ruiz-Pacheco R.... Sultan C.	1993	GH1
38	Detection of growth hormone gene deletions by PCR of the hGH-N gene in isolated growth hormone deficiency. (8268930)	Ruiz-Pacheco R.... Sultan C.	1993	GH1
39	Treatment of isolated growth hormone deficiency type IA due to GH-I gene deletion with recombinant human insulin-like growth factor I. (7509217)	Nishi Y.... Hasegawa T.	1993	IGF1
40	Familial isolated growth-hormone deficiency with advanced sexual maturation. (8427240)	Kauschansky A.... Frydman M.	1993	POMC
41	Isolated growth hormone deficiency: analysis of the g rowth hormone (GH)-releasing hormone gene and the GH gene cluster. (1967179)	Mullis P.... Brook C.G.	1990	GH1

Genes related to isolated growth hormone deficiency according to GeneCards:

(show all 19)

id	Symbol	Description	Score	GeneCards Section Context
1	GHRHR	growth hormone releasing hormone receptor	11.1	Summaries, Publications
2	SOX3	SRY (sex determining region Y)-box 3	11.1
3	CSHL1	chorionic somatomammotropin hormone-like 1	11.0	Publications
4	CSH1	chorionic somatomammotropin hormone 1 (placental lactogen)	11.0	Publications
5	GHRH	growth hormone releasing hormone	11.0	Publications
6	BTK	Bruton agammaglobulinemia tyrosine kinase	11.0	Publications
7	IGF1	insulin-like growth factor 1 (somatomedin C)	11.0	Publications
8	HESX1	HESX homeobox 1	11.0	Publications
9	GH2	growth hormone 2	11.0	Publications
10	OTX2	orthodenticle homeobox 2	11.0	Publications
11	POU1F1	POU class 1 homeobox 1	11.0	Publications
12	SLC20A1	solute carrier family 20 (phosphate transporter), member 1	11.0	Publications
13	LHX4	LIM homeobox 4	11.0	Publications
14	GH1	growth hormone 1	11.0	Publications
15	GHSR	growth hormone secretagogue receptor	11.0	Publications
16	PAX6	paired box 6	11.0	Publications
17	POMC	proopiomelanocortin	11.0	Publications
18	CD40LG	CD40 ligand	11.0	Publications
19	CD79A	CD79a molecule, immunoglobulin-associated alpha	11.0	Publications

Pathways related to isolated growth hormone deficiency according to GeneDecks:

(show all 48)

id	Pathway	Score	Top Affiliating Genes
1	Ras Pathway36	10.2	GHRH
2	Growth Hormone Signaling36	9.9	GH2, GH1, IGF1
3	Transcription factors in neurogenesis10	9.8	SOX3, PAX6, OTX2
4	GHRH Signaling36	9.8	GHRHR, GHRH, GH2, GH1
5	Apoptotic Pathways in Synovial Fibroblasts36	9.7	GH2, GHRH, IGF1, GH1
6	p53 Mediated Apoptosis36	9.7	GHRH, IGF1, GH1, GH2
7	Glioma Invasiveness36	9.7	IGF1, GH1, GHRH, GH2
8	Telomerase Components in Cell Signaling36	9.7	GH2, GH1, GHRH, IGF1
9	Mitochondrial Apoptosis36	9.7	GHRH, GH2, IGF1, GH1
10	NF-KappaB (p50-p65) Pathway36	9.7	GHRH, GH2, IGF1, GH1
11	DHA Signaling36	9.7	IGF1, GH1, GH2, GHRH
12	NF-KappaB Family Pathway36	9.7	GH2, IGF1, GH1, GHRH
13	mTOR Pathway36	9.7	GHRH, GH2, GH1, IGF1
14	ERK5 Signaling36	9.6	IGF1, GH1, GH2, GHRH
15	Cellular Apoptosis Pathway36	9.6	GHRH, IGF1, GH1, GH2
16	PPAR Pathway36	9.6	GH1, IGF1, GH2, GHRH
17	eIF2 Pathway36	9.6	IGF1, GHRH, GH2, GH1
18	Nanog in Mammalian ESC Pluripotency36	9.6	GH2, GH1, GHRH, IGF1
19	Nuclear Receptor Activation by Vitamin-A36	9.6	IGF1, GHRH, GH1, GH2
20	Rac1 Pathway36	9.6	GH2, GH1, IGF1, GHRH
21	Actin-Based Motility by Rho Family GTPases36	9.6	GHRH, GH2, IGF1, GH1
22	p70S6K Signaling36	9.5	GH1, GHRH, IGF1, GH2
23	Activation of PKC through GPCR36	9.5	GH1, GH2, GHRH, IGF1
24	TGF-Beta Pathway36	9.5	GHRH, IGF1, GH1, BTK, GH2
25	PAK Pathway36	9.5	GH2, GH1, BTK, IGF1, GHRH
26	JNK Pathway36	9.5	BTK, GHRH, GH2, GH1, IGF1
27	Paxillin Interactions36	9.5	IGF1, GHRH, GH2, GH1
28	MAPK Family Pathway36	9.5	GHRH, BTK, IGF1, GH1, GH2
29	JAK-STAT Pathway36	9.5	BTK, GH2, IGF1, GH1, GHRH
30	Tec Kinases Signaling36	9.5	BTK, GH2, GHRH, GH1, IGF1
31	Renin-Angiotensin Pathway36	9.4	GH2, GH1, IGF1, GHRH
32	14-3-3 Induced Intracellular Signaling36	9.4	GHRH, GH1, GH2, IGF1
33	Antioxidant Action of Vitamin-C36	9.4	GHRH, GH1, IGF1, BTK, GH2
34	p38 Signaling36	9.4	GH1, GH2, BTK, IGF1, GHRH
35	Rap1 Pathway36	9.4	IGF1, GH1, GHRH, GH2
36	Neuroactive ligand-receptor interaction20	9.3	CSH1, GH2, GHRHR, GHSR, GH1
37	Akt Signaling36	9.3	BTK, IGF1, GH1, GH2, GHRH
38	Primary immunodeficiency20	9.3	BTK, CD79A, CD40LG
39	CREB Pathway36	9.3	GHRH, GH1, IGF1, GH2
40	Rho Family GTPases36	9.3	BTK, GH1, GH2, GHRH, IGF1
41	Molecular Mechanisms of Cancer36	9.2	SOX3, GH2, GHRH, BTK, IGF1, GH1
42	Pancreatic Adenocarcinoma36	9.2	GH1, GHRH, IGF1, GH2
43	eNOS Signaling36	9.0	GH1, GH2, IGF1, GHRH
44	IP3 Pathway36	9.0	GH2, BTK, CD79A, IGF1, GH1, GHRH
45	NFAT in Immune Response36	9.0	CD79A, IGF1, GH1, GH2, GHRH, BTK
46	Phospholipase-C Pathway36	9.0	GHRH, BTK, CD79A, IGF1, GH1, GH2
47	ERK Signaling36	9.0	IGF1, BTK, PAX6, GH1, GH2, GHRH
48	Immune System38	8.6	GH2, CSH1, CD40LG, CD79A, GH1

Compounds related to isolated growth hormone deficiency according to GeneDecks:

(show top 50)    (show all 64)

id	Compound	Score	Top Affiliating Genes
1	ivig32	10.3	BTK
2	somatuline32	10.1	IGF1, GH1
3	mk-067732	10.1	IGF1, GHSR
4	quinagolide32	10.1	IGF1, GH1
5	pyridostigmine32 9 9	12.0	GH1, GHRH, IGF1
6	pegvisomant32 9 9	12.0	IGF1, GH1, GHRH
7	acipimox32	10.0	IGF1, GH1, GHRH
8	pirenzepine32 9 9	12.0	GH1, IGF1, GHRH
9	estradiol32 9 18 9	12.9	POMC, GHRH
10	oxandrolone32 9 9	11.9	IGF1, GH1
11	hcrh32	9.7	POMC, GHSR
12	salbutamol32 34 9 18 9	13.6	GHRH, CD79A, GH1
13	lanreotide32	9.6	IGF1, GHRH, GHSR, GH1
14	cortisone32 18	10.6	GH1, POMC, IGF1
15	sulfolipid i32	9.5	CD40LG, CD79A
16	naloxone32 34 9 9	12.5	GH1, GHRH, POMC
17	sandoglobulin32	9.4	CD40LG, CD79A
18	dehydroepiandrosterone sulfate32	9.4	POMC, GH1, IGF1
19	naltrexone32 34 9 9	12.4	GH1, POMC, IGF1, GHRH
20	ghrp32	9.4	GHSR, GHRHR, GHRH, GH1, IGF1
21	clonidine32 9 9	11.4	IGF1, GHRH, POMC, GH1
22	clomiphene citrate32	9.4	CD40LG, IGF1, GH1
23	triiodothyronine32	9.3	GHRH, GH1, IGF1, POMC
24	glutamate32	9.2	CD79A, GHRH, POU1F1, GHRHR
25	metformin32 34 9 9	12.2	GH1, POMC, IGF1
26	valproate32	9.1	IGF1, CD40LG, CD79A
27	gnrh32	9.1	IGF1, GHRH, GH1, POMC, HESX1
28	bromocriptine32 9 9	11.1	POMC, GHRH, POU1F1, IGF1, GH1
29	vitamin d32	9.1	GHRH, CD79A, IGF1, GH1, POU1F1
30	hydrocortisone32 9 9	11.1	POMC, GHSR, GH1, IGF1
31	octreotide32 42 9 9	11.9	GHSR, GH1, IGF1, GHRH, POMC
32	opiate32	8.9	GHRH, GH1, POMC
33	testosterone32 9 18 9	11.8	GHSR, CD40LG, GH2, CD79A
34	vitamin b1232	8.8	CD79A, CD40LG, IGF1
35	hexarelin32	8.8	GHRHR, GHSR, GHRH, POMC, GH1, IGF1
36	forskolin32 42 9 9	11.6	POU1F1, POMC, GHSR, GHRHR, GHRH, GH1
37	acth32	8.4	IGF1, GHRH, POMC, GH1, POU1F1, HESX1
38	norepinephrine32 9 18 9	11.2	GHRH, GH1, CD79A, CD40LG, POMC
39	ribonucleic acid32	8.1	POMC, GHSR, POU1F1, GHRH, GH2, GH1
40	adenylate32	8.1	POMC, GH1, GHRH, GHRHR, CD40LG, GHSR
41	steroid32	8.1	IGF1, GH1, GHRH, GHSR, POMC, CD79A
42	thyroxine32 18	9.0	POMC, IGF1, CD79A, CD40LG, GH1, GHRH
43	glucose32	7.9	POMC, IGF1, GH1, GH2, GHRH, GHRHR
44	vegf32	7.5	PAX6, CD79A, CD40LG, IGF1, GH1, POMC
45	alanine32	7.4	PAX6, CD40LG, GH1, SOX3, POMC, POU1F1
46	dopamine32 9 18 9	10.3	CD40LG, POU1F1, POMC, GHSR, GHRH, GH1
47	estrogen32	7.3	POMC, CD40LG, GHSR, IGF1, POU1F1, GH1
48	serine32	7.1	POMC, GHSR, GHRH, IGF1, CD40LG, PAX6
49	dexamethasone32 42 34 9 9	11.1	GHRH, POMC, CD79A, POU1F1, IGF1, GH1
50	arginine32	6.0	IGF1, GH1, BTK, GHRH, GHRHR, GHSR

Biological processes related to isolated growth hormone deficiency according to GeneDecks:

(show all 10)

id	Name	GO ID	Score	Top Affiliating Genes
1	water homeostasis	GO:030104	10.1	GHRHR, IGF1
2	positive regulation of growth hormone secretion	GO:060124	10.1	GHRHR, GHRH
3	response to food	GO:032094	9.8	GHSR, GHRH
4	growth hormone secretion	GO:030252	9.8	GHSR, GHRH, GHRHR
5	JAK-STAT cascade involved in growth hormone signaling pathway	GO:060397	9.7	CSH1, GH1, GH2
6	positive regulation of multicellular organism growth	GO:040018	9.4	GHSR, GHRH, GH1, GHRHR
7	organ morphogenesis	GO:009887	9.4	SOX3, LHX4, PAX6
8	positive regulation of insulin-like growth factor receptor signaling pathway	GO:043568	9.2	GHSR, GHRHR, GHRH, GH1, IGF1
9	B cell proliferation	GO:042100	8.8	CD40LG, CD79A
10	positive regulation of transcription, DNA-dependent	GO:045893	8.7	PAX6, IGF1, GHRH, OTX2, POU1F1

Molecular functions related to isolated growth hormone deficiency according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	growth hormone-releasing hormone receptor activity	GO:016520	9.8	GHRHR, GHSR
2	hormone activity	GO:005179	8.2	IGF1, GH1, GH2, CSH1, CSHL1, POMC