MCID: JPN002
MIFTS: 59

Japanese Encephalitis

Categories: Rare diseases, Infectious diseases, Neuronal diseases

Aliases & Classifications for Japanese Encephalitis

MalaCards integrated aliases for Japanese Encephalitis:

Name: Japanese Encephalitis 12 72 49 55 3 3 14 69
Je 49 3
Japanese B Encephalitis 12
Encephalitis, Japanese 41
Encephalitis Japanese 51

Characteristics:

Orphanet epidemiological data:

55
japanese encephalitis
Inheritance: Not applicable; Age of onset: All ages; Age of death: any age;

Classifications:



External Ids:

Disease Ontology 12 DOID:10844
ICD10 32 A83.0
ICD9CM 34 062.0
MeSH 41 D004672
NCIt 46 C34577
Orphanet 55 ORPHA79139
MESH via Orphanet 42 D004672
UMLS via Orphanet 70 C0014057
ICD10 via Orphanet 33 A83.0
UMLS 69 C0014057

Summaries for Japanese Encephalitis

CDC : 3 Japanese encephalitis (JE) virus is the leading cause of vaccine-preventable encephalitis in Asia and the western Pacific. For most travelers to Asia, the risk for JE is very low but varies based on destination, duration of travel, season, and activities. JE virus is maintained in a cycle involving mosquitoes and vertebrate hosts, mainly pigs and wading birds. Humans can be infected when bitten by an infected mosquito. Most human infections are asymptomatic or result in only mild symptoms. However, a small percentage of infected persons develop inflammation of the brain (encephalitis), with symptoms including sudden onset of headache, high fever, disorientation, coma, tremors and convulsions. About 1 in 4 cases are fatal. There is no specific treatment for JE. Patient management focuses on supportive care and management of complications. Steps to prevent JE include using personal protective measures to prevent mosquito bites and vaccination.

MalaCards based summary : Japanese Encephalitis, also known as je, is related to west nile virus and venezuelan equine encephalitis, and has symptoms including headache, high fever and neck stiffness. An important gene associated with Japanese Encephalitis is CD209 (CD209 Molecule), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Ethanol and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include brain, brain and t cells, and related phenotypes are hematopoietic system and homeostasis/metabolism

Disease Ontology : 12 A viral infectious disease that results_in infection located in brain, has material basis in Japanese encephalitis virus, which is transmitted_by Culex tritaeniorhynchus mosquito bite. The infection has symptom headache, has symptom high fever, has symptom neck stiffness, has symptom stupor, has symptom disorientation, has symptom coma, has symptom tremors, has symptom convulsions, and has symptom spastic paralysis.

Wikipedia : 72 Japanese encephalitis (JE) is an infection of the brain caused by the Japanese encephalitis virus (JEV).... more...

Related Diseases for Japanese Encephalitis

Diseases related to Japanese Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 111)
# Related Disease Score Top Affiliating Genes
1 west nile virus 30.0 CD209 CLEC4M DDX58 TLR3
2 venezuelan equine encephalitis 29.6 IFNB1 STAT1
3 hemorrhagic fever 29.6 CD209 TNF
4 tick-borne encephalitis 29.6 CD209 CXCL10 TLR3
5 dengue hemorrhagic fever 29.4 CD209 STAT1 TNF
6 encephalitis 29.3 CCL5 CD209 CLEC4G CLEC4M CXCL10 DDX58
7 yellow fever 29.3 CCL5 IFNB1 STAT1
8 herpes simplex 29.1 CD209 DDX58 IFNB1 TLR3
9 avian influenza 29.0 CXCL10 DDX58 TNF
10 chikungunya 28.9 CCL5 DDX58 TNF
11 viral encephalitis 28.8 CCL5 CXCL10 TNF
12 rabies 28.3 CCL5 CXCL10 STAT1 TLR3
13 influenza 28.3 CCL5 DDX58 IFNB1 TLR3
14 hepatitis c 27.2 CLEC4M CXCL10 DDX58 IFNB1 STAT1 TLR3
15 zika fever 10.3 IFNB1 STAT1
16 la crosse encephalitis 10.2 DDX58 IFNB1
17 retinal vasculitis 10.2 IFNB1 TLR3
18 newcastle disease 10.2 DDX58 IFNB1
19 dengue virus 10.1
20 acute myocarditis 10.1 STAT1 TLR3
21 listeria meningitis 10.1 IFNB1 TNF
22 microphthalmia with limb anomalies 10.1 IFNB1 STAT1
23 neuronitis 10.0
24 mucocutaneous leishmaniasis 10.0 TLR3 TNF
25 compartment syndrome 10.0 HELLS TNF
26 marburg hemorrhagic fever 10.0 CD209 IFNB1 TNF
27 respiratory syncytial virus infectious disease 10.0 CCL5 IFNB1
28 crimean-congo hemorrhagic fever 9.9 CXCL10 TNF
29 noonan syndrome 5 9.9
30 murray valley encephalitis 9.9
31 noonan syndrome 3 9.9
32 blood group, i system 9.9
33 aging 9.9
34 stromal keratitis 9.9 CXCL10 TNF
35 acute cervicitis 9.8 CCL5 CXCL10
36 neuroblastoma 9.8
37 malaria 9.8
38 endotheliitis 9.8
39 central nervous system tuberculosis 9.8 CXCL10 STAT1
40 progressive multifocal leukoencephalopathy 9.8 STAT1 TNF
41 scorpion envenomation 9.8 CCL5 TNF
42 mycobacterium tuberculosis 1 9.8 CD209 CXCL10 TNF
43 hepatitis e 9.8 DDX58 TLR3 TNF
44 extrinsic cardiomyopathy 9.8 IFNB1 TLR3 TNF
45 multiple mitochondrial dysfunctions syndrome 5 9.8
46 ring chromosome y syndrome 9.8
47 orofacial granulomatosis 9.7 CCL5 TNF
48 stachybotrys chartarum 9.7 CCL5 TNF
49 medulloblastoma 9.7
50 pigmentary disorder, reticulate, with systemic manifestations, x-linked 9.7

Graphical network of the top 20 diseases related to Japanese Encephalitis:



Diseases related to Japanese Encephalitis

Symptoms & Phenotypes for Japanese Encephalitis

Symptoms:

12
  • headache
  • high fever
  • neck stiffness
  • stupor
  • disorientation
  • coma
  • tremors
  • convulsions
  • spastic paralysis

MGI Mouse Phenotypes related to Japanese Encephalitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.96 TLR3 CCL5 TNF CLEC4G CLEC4M CXCL10
2 homeostasis/metabolism MP:0005376 9.81 TLR3 TNF CLEC4G CLEC4M CXCL10 DDX58
3 immune system MP:0005387 9.65 TLR3 CCL5 TNF CLEC4G CLEC4M CXCL10
4 neoplasm MP:0002006 9.02 TLR3 TNF DDX58 IFNB1 STAT1

Drugs & Therapeutics for Japanese Encephalitis

Drugs for Japanese Encephalitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Phase 4 64-17-5 702
2 Antibodies Phase 4,Phase 3,Phase 2,Phase 1
3 Immunoglobulins Phase 4,Phase 3,Phase 2,Phase 1
4 Vaccines Phase 4,Phase 3,Phase 2,Phase 1
5 Antibodies, Blocking Phase 4,Phase 3,Phase 2
6
Aluminum hydroxide Approved, Investigational Phase 3,Phase 1 21645-51-2
7
Lactitol Investigational Phase 3 585-86-4 3871
8 DEET Phase 3
9 Insect Repellents Phase 3
10 Protective Agents Phase 3
11 Pharmaceutical Solutions Phase 3
12 Heptavalent Pneumococcal Conjugate Vaccine Phase 3
13
Ribavirin Approved Phase 2 36791-04-5 37542
14
Neomycin Approved, Vet_approved Phase 1, Phase 2 1404-04-2 8378
15 Anti-Infective Agents Phase 2
16 Antimetabolites Phase 2
17 Antiviral Agents Phase 2
18 gamma-Globulins Phase 2
19 Immunoglobulins, Intravenous Phase 2
20 Rho(D) Immune Globulin Phase 2
21
Aluminum sulfate Approved Phase 1 10043-01-3

Interventional clinical trials:

(show top 50) (show all 81)

# Name Status NCT ID Phase Drugs
1 Antibody Response of a Boosted Japanese Encephalitis Chimeric Virus Vaccine (JE-CV) in Children Unknown status NCT01954810 Phase 4
2 Cellular and Humoral Immunity in Elderly After Immunization With a Japanese Encephalitis Vaccine Unknown status NCT01398540 Phase 4
3 A Prospective, Open Label Study of Human T Cell Responses to Live Attenuated Japanese Encephalitis Vaccine SA14-14-2 Completed NCT01656200 Phase 4
4 Long-term Immunogenicity and Safety of Fourth Administration of Boryung Cell-Culture Japanese Encephalitis Vaccineinj Completed NCT02532569 Phase 4
5 Immunogenicity of Co-administration of Measles and Japanese Encephalitis Vaccines Completed NCT02643433 Phase 4
6 Immunogenicity of a Live Attenuated Chimeric JE Vaccine (IMOJEV) as a Booster Dose in Thai Children Primed With CD.JEVAX Completed NCT02526550 Phase 4
7 Immunogenicity and Safety of Japanese Encephalitis Vaccine When Given With Measles-Mumps-Rubella Vaccine Completed NCT02880865 Phase 4
8 This is a Study to Assess the Safety and Immunogenicity of Ixiaro® (IC51) in an Elderly Population Completed NCT01158599 Phase 4
9 6-year Antibody Check After Third Vaccination Against Japanese Encephalitis Completed NCT02039440 Phase 4
10 Post-licensure Safety Study of IMOJEV® in Thailand Completed NCT01981967 Phase 4
11 Lot-to-lot Consistency Trial of JE Live Attenuated SA 14-14-2 Vaccine Completed NCT01567865 Phase 4
12 Long-term Immunogenicity After Receipt of JE Vaccine and Antibody Response and Safety to a Booster Dose Completed NCT02514746 Phase 4
13 Immunogenicity of SA 14-14-2 JE Vaccine Completed NCT01635816 Phase 4
14 Immunogenicity and Safety of Live Attenuated Varicella Vaccine Combined With Live Attenuated JE Vaccine Completed NCT01815073 Phase 4
15 The Phase IVd of Inactivated Enterovirus 71 Vaccine Enrolling by invitation NCT03296410 Phase 4
16 Clinical Evaluation of Insect Repellent and Insecticide Treated Nets in Lao PDR Unknown status NCT00938379 Phase 3 20% deet insect repellent;placebo control
17 Study of a Live Attenuated Japanese Encephalitis Chimeric Virus Vaccine (IMOJEV™) Compared to CD.JEVAX™ in Toddlers Completed NCT01396512 Phase 3
18 A Study of Japanese Encephalitis Chimeric Virus Vaccine Compared With SA14-14-2 Vaccine in Infants and Toddlers Completed NCT01092507 Phase 3
19 Longterm Immunogenicity of the Japanese Encephalitis Vaccine IC51 Completed NCT00596102 Phase 3
20 Study of a Single Primary Dose Live Attenuated Japanese Encephalitis Chimeric Virus Vaccine (IMOJEV®) in Healthy Subjects Completed NCT02492165 Phase 3
21 Study of Japanese Encephalitis Chimeric Virus Vaccine Given With Measles-Mumps-Rubella Vaccine in Taiwanese Toddlers Completed NCT01188343 Phase 3
22 Ixiaro as Booster After Mouse-brain Derived Vaccines for Japanese Encephalitis Completed NCT01386827 Phase 3
23 Safety and Immunogenicity of 2 Different Vaccination Schedules of Rabies and Japanese Encephalitis Vaccines in Healthy Adult Subjects Completed NCT01662440 Phase 3
24 Rapid Immunization Study of the Japanese Encephalitis Vaccine IC51 Completed NCT00595790 Phase 3
25 Immunogenicity Study of the Japanese Encephalitis Vaccine IC51 Completed NCT00604708 Phase 3
26 Long Term Persistence and Effect of a Booster Dose of the Japanese Encephalitis Vaccine IC51 Completed NCT00595270 Phase 3
27 Live Attenuated Japanese Encephalitis (JE) Vaccine Coadministered With Measles Vaccine in Infants 9 Months of Age Completed NCT00463684 Phase 3
28 Boosterability of Live Attenuated Japanese Encephalitis (JE) Vaccine in Children Who Have Previously Received Inactivated JE Vaccine Completed NCT00463476 Phase 3
29 Study of ChimeriVax™-Japanese Encephalitis Vaccine in Toddlers in Thailand and the Philippines Completed NCT00735644 Phase 3
30 Safety and Tolerability of the Japanese Encephalitis Vaccine IC51 Completed NCT00605085 Phase 3
31 Study of a Booster Dose of IMOJEV® One Year After Primary Immunization in Healthy Children in South Korea Completed NCT01900444 Phase 3
32 A Clinical Trial for Inactivated Japanese Encephalitis Vaccine in Healthy Chinese Infants Completed NCT02367664 Phase 3
33 Comparison of Three Commercial Batches of the Japanese Encephalitis Vaccine IC51 Completed NCT00595465 Phase 3
34 Comparison of Three Batches of the Japanese Encephalitis Vaccine IC51 Completed NCT00594958 Phase 3
35 A Safety and Efficacy Study of Two Japanese Encephalitis Vaccines ChimeriVax™-JE and JE-VAX Completed NCT00314145 Phase 3
36 Study of Japanese Encephalitis Chimeric Virus Vaccine (JE-CV) in Children Previously Immunized With JE-CV Completed NCT01190228 Phase 3
37 Determining Safety and Efficacy of Japanese Encephalitis Vaccine When Given With Measles Vaccine Completed NCT00249769 Phase 3
38 Concomitant Vaccination With the Japanese Encephalitis Vaccine IC51 and HARVIX® 1440 Completed NCT00596271 Phase 3
39 Safety and Immunogenicity of the Japanese Encephalitis Vaccine IC51 (IXIARO®) in a Pediatric Population Completed NCT01041573 Phase 3
40 Open-label, Randomized Study in a Pediatric Population in a JEV (Japanese Encephalitis Virus)-Endemic Country Completed NCT01296360 Phase 3
41 Safety Study of ChimeriVax™-JE Vaccine to Prevent Japanese Encephalitis. Completed NCT00314132 Phase 3
42 Long-term Follow-up of Immunogenicity of a Single Dose of Japanese Encephalitis Chimeric Virus Vaccine (JE-CV) in Toddlers Completed NCT01001988 Phase 3
43 Effect of a Booster Dose of the Japanese Encephalitis Vaccine IC51 Completed NCT00595309 Phase 3
44 Immunogenicity of a Commercial Batch of JEV IC51 up to 24 Months Post Filling Completed NCT00776230 Phase 3
45 Immunogenicity and Safety of Inactivated Vero Cell Derived Japanese Encephalitis Vaccine in Thai Children Completed NCT01408537 Phase 3
46 Determining Long-Term Safety and Efficacy of Japanese Encephalitis Vaccine When Given With Measles Vaccine Completed NCT00412516 Phase 3
47 Immunogenicity and Safety of the Japanese Encephalitis Vaccine IC51 (IXIARO®, JESPECT®) in a Pediatric Population in Non-endemic Countries Completed NCT01047839 Phase 3
48 Clinical Trial to Assess the Immunogenicity and Safety of the Vero Cell-derived JE Vaccine in Korea Completed NCT01150942 Phase 3
49 Long Term Immunity and Safety Following Vaccination With the JEV IC51 (IXIARO®, JESPECT®) in Pediatric Population In Non Endemic Countries. Uncontrolled, Ph3 FU-Study Completed NCT01246479 Phase 3
50 A Phase 3b, Randomized, Open-Label Study to Evaluate the Safety and Immunogenicity of Select Travel Vaccines When Administered Concomitantly With MenACWY in Adults Completed NCT01466387 Phase 3

Search NIH Clinical Center for Japanese Encephalitis

Cochrane evidence based reviews: encephalitis, japanese

Genetic Tests for Japanese Encephalitis

Anatomical Context for Japanese Encephalitis

The Foundational Model of Anatomy Ontology organs/tissues related to Japanese Encephalitis:

18
Brain

MalaCards organs/tissues related to Japanese Encephalitis:

38
Brain, T Cells, B Cells, Testes, Endothelial, Kidney, Monocytes

Publications for Japanese Encephalitis

Articles related to Japanese Encephalitis:

(show top 50) (show all 718)
# Title Authors Year
1
Meta-Analyses of Japanese Encephalitis Virus Infection, Dissemination, and Transmission Rates in Vectors. ( 29363456 )
2018
2
A Simple Mechanism Based on Amino Acid Substitutions is not a Critical Determinant of High Mortality of Japanese Encephalitis Virus Infection in Mice. ( 29401664 )
2018
3
Changes of Epidemiological Characteristics of Japanese Encephalitis Viral Infection and Birds as a Potential Viral Transmitter in Korea. ( 29441740 )
2018
4
Effect of prior dengue infection on severity and outcome of Japanese encephalitis. ( 29411187 )
2018
5
Risk assessment for Japanese encephalitis vaccination. ( 29244615 )
2018
6
Immunogenicity and safety of inactivated chromatographically purified Vero cell-derived Japanese encephalitis vaccine in Thai children. ( 29227177 )
2018
7
Structural study of the C-terminal domain of non-structural protein 1 from Japanese encephalitis virus. ( 29343583 )
2018
8
Structural basis for neutralization of Japanese encephalitis virus by two potent therapeutic antibodies. ( 29379207 )
2018
9
Long-term immunogenicity of an initial booster dose of an inactivated, Vero cell culture-derived Japanese encephalitis vaccine (JE-VC) and the safety and immunogenicity of a second JE-VC booster dose in children previously vaccinated with an inactivated, mouse brain-derived Japanese encephalitis vaccine. ( 29429815 )
2018
10
Mutation of I176R in the E coding region weakens Japanese encephalitis virus neurovirulence, but not its growth rate in BHK-21 cells. ( 29411136 )
2018
11
Five-Year Antibody Persistence Following a Japanese Encephalitis Chimeric Virus Vaccine (JE-CV) Booster in JE-CV-Primed Children in the Philippines. ( 29325161 )
2018
12
Antisense Oligonucleotides Targeting Raf-1 Block Japanese Encephalitis Virus In Vitro and In Vivo. ( 28051352 )
2017
13
Autochthonous Japanese Encephalitis with Yellow Fever Coinfection in Africa. ( 28402771 )
2017
14
Japanese encephalitis virus induces human neural stem/progenitor cell death by elevating GRP78, PHB and hnRNPC through ER stress. ( 28102850 )
2017
15
Regulation of inflammation in Japanese encephalitis. ( 28807053 )
2017
16
Expression of domain III of the envelope protein from GP-78: a Japanese encephalitis virus. ( 28770248 )
2017
17
Post-licensure, phase IV, safety study of a live attenuated Japanese encephalitis recombinant vaccine in children in Thailand. ( 27903416 )
2017
18
Rab5 and Rab11 Are Required for Clathrin-Dependent Endocytosis of Japanese Encephalitis Virus in BHK-21 Cells. ( 28724764 )
2017
19
Dual infection with Japanese encephalitis and dengue fever: Issues with diagnosis. ( 28084252 )
2017
20
Mx Is Not Responsible for the Antiviral Activity of Interferon-I+ against Japanese Encephalitis Virus. ( 28075421 )
2017
21
Introducing a cleavable signal peptide enhances the packaging efficiency of lentiviral vectors pseudotyped with Japanese encephalitis virus envelope proteins. ( 27993624 )
2017
22
Plasmid DNA launches live-attenuated Japanese encephalitis virus and elicits virus-neutralizing antibodies in BALB/c mice. ( 28938099 )
2017
23
Enhanced cytopathic effect of Japanese encephalitis virus strain SA14-14-2: Probable association of mutation in amino acid of its envelope protein. ( 28867626 )
2017
24
Screening of FDA-Approved Drugs for Inhibitors against Japanese Encephalitis Virus Infection. ( 28814523 )
2017
25
Diagnostic dilemma-dengue or Japanese encephalitis? ( 28084251 )
2017
26
Isolation and full-genome sequences of Japanese encephalitis virus genotype I strains from Cambodian human patients, mosquitoes and pigs. ( 28840803 )
2017
27
Immunogenicity of a Live Attenuated Chimeric Japanese Encephalitis Vaccine as a Booster Dose After Primary Vaccination With Live Attenuated SA14-14-2 Vaccine: A Phase IV Study in Thai Children. ( 27846060 )
2017
28
Susceptibility status of Japanese Encephalitis vectors to insecticides in endemic areas of northern districts of West Bengal, India. ( 29279446 )
2017
29
Incidence of Japanese Encephalitis amongst acute encephalitis syndrome cases in upper Assam districts from 2012 to 2014: A report from a tertiary care hospital. ( 29265029 )
2017
30
Updated estimation of the impact of a Japanese encephalitis immunization program with live, attenuated SA 14-14-2 vaccine in Nepal. ( 28934197 )
2017
31
Development of a stable Japanese encephalitis virus replicon cell line for antiviral screening. ( 28779235 )
2017
32
GRP78 is an important host-factor for Japanese encephalitis virus entry and replication in mammalian cells. ( 28053106 )
2017
33
The host microRNA miR-301a blocks the IRF1-mediated neuronal innate immune response to Japanese encephalitis virus infection. ( 28196914 )
2017
34
Use of the live attenuated Japanese Encephalitis vaccine SA 14-14-2 in children: A review of safety and tolerability studies. ( 28841362 )
2017
35
Serological and molecular epidemiology of Japanese encephalitis virus infections in swine herds in China, 2006-2012. ( 28693301 )
2017
36
Clinical Characteristics of Severe Japanese Encephalitis: A Case Series from South Korea. ( 28829730 )
2017
37
Opsoclonus myoclonus syndrome in a patient with Japanese encephalitis: a case report. ( 29058581 )
2017
38
Prolonged Detection of Japanese Encephalitis Virus in Urine and Whole Blood in a Returned Short-term Traveler. ( 29226169 )
2017
39
Full-Length Genome Sequence of Japanese Encephalitis Virus Strain FC792, Isolated from Guangxi, China. ( 29192069 )
2017
40
Dengue virus and Japanese encephalitis virus infection of the central nervous system share similar profiles of cytokine accumulation in cerebrospinal fluid. ( 28860941 )
2017
41
Japanese encephalitis virus counteracts BST2 restriction via its envelope protein E. ( 28710958 )
2017
42
Poor performance of two rapid immunochromatographic assays for anti-Japanese encephalitis virus immunoglobulin M detection in cerebrospinal fluid and serum from patients with suspected Japanese encephalitis virus infection in Laos. ( 29244182 )
2017
43
miR-301a mediated immune evasion by Japanese encephalitis virus. ( 29207584 )
2017
44
The changing epidemiology of Japanese encephalitis and New data: the implications for New recommendations for Japanese encephalitis vaccine. ( 28883984 )
2017
45
DC-SIGN promotes Japanese encephalitis virus transmission from dendritic cells to T cells via virological synapses. ( 28865053 )
2017
46
Inhibition of Japanese encephalitis virus (JEV) replication by specific RNA aptamer against JEV methyltransferase. ( 27986564 )
2017
47
The molecular determinants governing the immunogenicity of Japanese encephalitis live attenuated vaccines. ( 29263913 )
2017
48
A highly pathogenic porcine reproductive and respiratory syndrome virus candidate vaccine based on Japanese encephalitis virus replicon system. ( 28740748 )
2017
49
Spatio-temporal epidemiology of Japanese encephalitis in Nepal, 2007-2015. ( 28746354 )
2017
50
Japanese Encephalitis Virus NS5 Inhibits Type I Interferon (IFN) Production by Blocking the Nuclear Translocation of IFN Regulatory Factor 3 and NF-I_B. ( 28179530 )
2017

Variations for Japanese Encephalitis

Expression for Japanese Encephalitis

Search GEO for disease gene expression data for Japanese Encephalitis.

Pathways for Japanese Encephalitis

Pathways related to Japanese Encephalitis according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.81 CCL5 CD209 CXCL10 DDX58 IFNB1 STAT1
2
Show member pathways
13.14 CCL5 CXCL10 DDX58 IFNB1 STAT1 TNF
3
Show member pathways
12.71 CCL5 CD209 IFNB1 STAT1 TLR3 TNF
4
Show member pathways
12.53 CCL5 CXCL10 DDX58 IFNB1 TNF
5
Show member pathways
12.35 DDX58 IFNB1 STAT1 TLR3 TNF
6 12.25 CCL5 CXCL10 DDX58 STAT1 TLR3 TNF
7
Show member pathways
12.08 IFNB1 TLR3 TNF
8
Show member pathways
12.08 STAT1 TLR3 TNF
9
Show member pathways
12.05 IFNB1 STAT1 TLR3 TNF
10
Show member pathways
12 CXCL10 IFNB1 STAT1 TNF
11 11.99 STAT1 TLR3 TNF
12
Show member pathways
11.97 IFNB1 STAT1 TNF
13 11.97 CD209 CLEC4M IFNB1 STAT1 TNF
14
Show member pathways
11.97 CCL5 CD209 CLEC4M CXCL10 DDX58 IFNB1
15
Show member pathways
11.92 CCL5 CXCL10 IFNB1 STAT1 TLR3 TNF
16 11.86 IFNB1 STAT1 TNF
17 11.78 CCL5 CXCL10 TNF
18
Show member pathways
11.75 STAT1 TLR3 TNF
19 11.67 DDX58 IFNB1 STAT1 TLR3 TNF
20 11.58 CD209 IFNB1 TNF
21 11.39 CCL5 CXCL10 TNF
22 11.2 CXCL10 IFNB1 STAT1
23 11.1 IFNB1 TNF
24 11.02 CCL5 CXCL10 TNF
25
Show member pathways
10.95 DDX58 STAT1
26 10.92 CCL5 IFNB1 TNF

GO Terms for Japanese Encephalitis

Biological processes related to Japanese Encephalitis according to GeneCards Suite gene sharing:

(show all 41)
# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.97 CD209 CLEC4M DDX58 TLR3
2 immune system process GO:0002376 9.97 CD209 CLEC4M DDX58 TLR3
3 regulation of receptor activity GO:0010469 9.95 CCL5 CXCL10 IFNB1 TNF
4 inflammatory response GO:0006954 9.93 CCL5 CXCL10 TLR3 TNF
5 viral process GO:0016032 9.91 CD209 CLEC4G CLEC4M DDX58 STAT1
6 cellular response to interferon-gamma GO:0071346 9.79 CCL5 STAT1 TLR3
7 viral entry into host cell GO:0046718 9.78 CD209 CLEC4G CLEC4M
8 cellular response to organic cyclic compound GO:0071407 9.77 CCL5 STAT1 TNF
9 positive regulation of smooth muscle cell proliferation GO:0048661 9.72 CCL5 STAT1 TNF
10 defense response GO:0006952 9.71 CXCL10 IFNB1 TLR3 TNF
11 positive regulation of interleukin-6 production GO:0032755 9.7 DDX58 TLR3 TNF
12 negative regulation of endothelial cell proliferation GO:0001937 9.68 STAT1 TNF
13 lipopolysaccharide-mediated signaling pathway GO:0031663 9.68 CCL5 TNF
14 regulation of type I interferon-mediated signaling pathway GO:0060338 9.68 IFNB1 STAT1
15 positive regulation of cytokine production GO:0001819 9.68 TLR3 TNF
16 positive regulation of defense response to virus by host GO:0002230 9.67 DDX58 STAT1
17 positive regulation of interferon-beta production GO:0032728 9.66 DDX58 TLR3
18 negative regulation of myoblast differentiation GO:0045662 9.66 CXCL10 TNF
19 positive regulation of NF-kappaB import into nucleus GO:0042346 9.65 TLR3 TNF
20 positive regulation of innate immune response GO:0045089 9.65 CCL5 IFNB1
21 positive regulation of chemokine production GO:0032722 9.64 TLR3 TNF
22 positive regulation of monocyte chemotaxis GO:0090026 9.64 CCL5 CXCL10
23 positive regulation of T cell migration GO:2000406 9.63 CCL5 CXCL10
24 negative regulation of viral genome replication GO:0045071 9.63 CCL5 IFNB1 TNF
25 viral genome replication GO:0019079 9.62 CD209 CLEC4M
26 positive regulation of interferon-alpha production GO:0032727 9.62 DDX58 STAT1
27 response to exogenous dsRNA GO:0043330 9.61 DDX58 IFNB1 TLR3
28 positive regulation of chemokine biosynthetic process GO:0045080 9.6 TLR3 TNF
29 modulation by virus of host morphology or physiology GO:0019048 9.58 CD209 CLEC4M
30 necroptotic signaling pathway GO:0097527 9.58 TLR3 TNF
31 cell-cell recognition GO:0009988 9.57 CD209 CLEC4M
32 detection of virus GO:0009597 9.54 DDX58 TLR3
33 leukocyte cell-cell adhesion GO:0007159 9.54 CCL5 CD209 CLEC4M
34 positive regulation of interleukin-8 production GO:0032757 9.5 DDX58 TLR3 TNF
35 virion attachment to host cell GO:0019062 9.49 CD209 CLEC4M
36 peptide antigen transport GO:0046968 9.48 CD209 CLEC4M
37 cellular response to exogenous dsRNA GO:0071360 9.43 DDX58 IFNB1 TLR3
38 defense response to virus GO:0051607 9.35 CXCL10 DDX58 IFNB1 STAT1 TLR3
39 cellular response to interferon-beta GO:0035458 9.33 IFNB1 STAT1 TLR3
40 response to virus GO:0009615 9.1 CCL5 CXCL10 DDX58 IFNB1 TLR3 TNF
41 positive regulation of transcription by RNA polymerase II GO:0045944 10.03 CXCL10 DDX58 IFNB1 STAT1 TLR3 TNF

Molecular functions related to Japanese Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.77 CCL5 DDX58 STAT1 TLR3 TNF
2 carbohydrate binding GO:0030246 9.63 CD209 CLEC4G CLEC4M
3 tumor necrosis factor receptor binding GO:0005164 9.43 STAT1 TNF
4 peptide antigen binding GO:0042605 9.4 CD209 CLEC4M
5 virus receptor activity GO:0001618 9.33 CD209 CLEC4G CLEC4M
6 mannose binding GO:0005537 9.32 CD209 CLEC4M
7 virion binding GO:0046790 9.26 CD209 CLEC4M
8 CCR5 chemokine receptor binding GO:0031730 8.96 CCL5 STAT1
9 cytokine activity GO:0005125 8.92 CCL5 CXCL10 IFNB1 TNF

Sources for Japanese Encephalitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....