JE
MCID: JPN002
MIFTS: 55

Japanese Encephalitis (JE) malady

Infectious diseases, Neuronal diseases categories

Summaries for Japanese Encephalitis

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8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
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CDC:3 Japanese encephalitis (JE) virus is the leading cause of vaccine-preventable encephalitis in Asia and the western Pacific. For most travelers to Asia, the risk for JE is very low but varies based on destination, duration of travel, season, and activities. JE virus is maintained in a cycle involving mosquitoes and vertebrate hosts, mainly pigs and wading birds. Humans can be infected when bitten by an infected mosquito. Most human infections are asymptomatic or result in only mild symptoms. However, a small percentage of infected persons develop inflammation of the brain (encephalitis), with symptoms including sudden onset of headache, high fever, disorientation, coma, tremors and convulsions. About 1 in 4 cases are fatal. There is no specific treatment for JE. Patient management focuses on supportive care and management of complications. Steps to prevent JE include using personal protective measures to prevent mosquito bites and vaccination.

MalaCards: Japanese Encephalitis, also known as japanese b encephalitis, is related to encephalitis and tick-borne encephalitis, and has symptoms including convulsions, coma and tremors. An important gene associated with Japanese Encephalitis is PTS (6-pyruvoyltetrahydropterin synthase), and among its related pathways are Influenza A and Immune System. The compounds cycloheximide and poly(i-c) have been mentioned in the context of this disorder. Affiliated tissues include brain, brain and b cells, and related mouse phenotype mortality/aging.

Disease Ontology:8 A viral infectious disease that results in infection located in brain, has material basis in japanese encephalitis virus, which is transmitted by culex tritaeniorhynchus mosquito bite. the infection has symptom headache, has symptom high fever, has symptom neck stiffness, has symptom stupor, has symptom disorientation, has symptom coma, has symptom tremors, has symptom convulsions, and has symptom spastic paralysis.

Wikipedia:63 Japanese encephalitis (Japanese: 日本脳炎, Nihon-nōen)—previously known as Japanese B... more...

Aliases & Classifications for Japanese Encephalitis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 60UMLS, 44Novoseek, 56SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
japanese encephalitis:
Inheritance: Sporadic; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

japanese encephalitis 8 42 10 48 60
japanese b encephalitis 8
encephalitis japanese 44
je 42


External Ids:

Disease Ontology8 DOID:10844
MeSH34 D004672
ICD9CM27 062.0
NCIt39 C34577
MESH via Orphanet35 D004672
ICD10 via Orphanet26 A83.0
SNOMED-CT via Orphanet57 52947006
UMLS via Orphanet61 C0014057
ICD1025 A83.0

Related Diseases for Japanese Encephalitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Japanese Encephalitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 61)
idRelated DiseaseScoreTop Affiliating Genes
1encephalitis32.0TAT, CXCL10
2tick-borne encephalitis30.4TUBE1
3yellow fever30.3PRNT
4dengue hemorrhagic fever29.9IVNS1ABP
5hepatitis29.9TAT, CXCL10, TXN
6influenza29.9TXN, DDX58, IVNS1ABP, CXCL10, TAT
7hepatitis c29.9CXCL10, HELLS, TXN
8astrocytoma29.9TAT, CXCL10
9viral encephalitis10.7
10west nile encephalitis10.7
11neuronitis10.4
12murray valley encephalitis10.4
13louping ill10.3
14encephalomyelitis10.2
15neuroblastoma10.2
16myelitis10.1
17cerebritis10.1
18chikungunya10.1
19hemiplegia10.1
20medulloblastoma10.1
21meningitis10.1
22epidemic typhus10.1
23typhus10.1
24newcastle disease10.0IVNS1ABP, CXCL10
25ebola hemorrhagic fever10.0DDX58, IFIT2
26sarcoma10.0TAT, FADD, HELLS
27tyrosinemia10.0TAT
28atherosclerosis10.0TXN, CXCL10, PTS
29hepatitis b10.0TAT, CXCL10, FADD, TXN
30viral infectious disease10.0TXN, HELLS, DDX58, IVNS1ABP, CXCL10, TAT
31ipex syndrome10.0TXN, HELLS, IVNS1ABP, CXCL10, TAT, PTS
32hyperphenylalaninemia10.0PTS
33ovarian cancer10.0HELLS, TXN
34dengue disease10.0IVNS1ABP, HELLS
35parkinson's disease10.0
36rift valley fever10.0
37neuromyelitis optica10.0
38kunjin encephalitis10.0
39avian influenza10.0
40visceral leishmaniasis10.0
41aseptic meningitis10.0
42west syndrome10.0
43west nile fever10.0
44st. louis encephalitis10.0
45western equine encephalitis10.0
46venezuelan equine encephalitis10.0
47acute disseminated encephalomyelitis10.0
48adult syndrome10.0
49basal ganglia disease10.0
50brain disease10.0

Graphical network of the top 20 diseases related to Japanese Encephalitis:



Diseases related to japanese encephalitis

Clinical Features for Japanese Encephalitis

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Sources:
8Disease Ontology
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Symptoms:

8 (show all 9)
  • convulsions
  • coma
  • tremors
  • spastic paralysis
  • neck stiffness
  • high fever
  • stupor
  • disorientation
  • headache

Drugs & Therapeutics for Japanese Encephalitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Japanese Encephalitis

Drug clinical trials:

Search ClinicalTrials for Japanese Encephalitis

Search NIH Clinical Center for Japanese Encephalitis

Search CenterWatch for Japanese Encephalitis

Genetic Tests for Japanese Encephalitis

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Anatomical Context for Japanese Encephalitis

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Japanese Encephalitis:

32
Brain, B cells, T cells, Testes, Endothelial, Kidney, Monocytes, Bone, Spleen, Myeloid

FMA organs/tissues related to Japanese Encephalitis:

14
Brain

Animal Models for Japanese Encephalitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Japanese Encephalitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107689.8PTS, IFIT2, HELLS, FADD, DDX58, IVNS1ABP

Publications for Japanese Encephalitis

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50PubMed
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Articles related to Japanese Encephalitis:

(show top 50)    (show all 554)
idTitleAuthorsYear
1
Antiviral activity of Rheum palmatum methanol extract and chrysophanol against Japanese encephalitis virus. (24395532)
2014
2
Development of a small animal peripheral challenge model of Japanese encephalitis virus using interferon deficient AG129 mice and the SA14-14-2 vaccine virus strain. (24252694)
2014
3
Outcome of children with Japanese encephalitis and predictors of outcome in southwestern China. (23900120)
2013
4
Japanese encephalitis virus disrupts cell-cell junctions and affects the epithelial permeability barrier functions. (23894488)
2013
5
Estimation of the impact of a Japanese encephalitis immunization program with live, attenuated SA 14-14-2 vaccine in Nepal. (23358643)
2013
6
Development of chimaeric West Nile virus attenuated vaccine candidate based on the Japanese encephalitis vaccine strain SA14-14-2. (24092759)
2013
7
Porcine alpha interferon inhibit Japanese encephalitis virus replication by different ISGs in vitro. (24012350)
2013
8
Japanese encephalitis in India: risk of an epidemic in the National Capital Region. (24030267)
2013
9
Recurrence of Japanese encephalitis epidemic in Wuhan, China, 2009-2010. (23326348)
2013
10
Feasibility of cross-protective vaccination against flaviviruses of the Japanese encephalitis serocomplex. (22309667)
2012
11
Seroprevalence of Japanese encephalitis virus and risk factors associated with seropositivity in pigs in four mountain districts in Nepal. (22883515)
2012
12
Comprehensive mapping of West Nile virus (WNV)- and Japanese encephalitis virus serocomplex-specific linear B-cell epitopes from WNV non-structural protein 1. (21940411)
2012
13
Mutation analysis of the cross-reactive epitopes of Japanese encephalitis virus envelope glycoprotein. (22337639)
2012
14
Concurrent infection of Japanese encephalitis and mixed plasmodium infection. (22837781)
2012
15
Retention of the mother and child health handbook and additional immunization of Japanese encephalitis and tetanus vaccine. (22916326)
2012
16
Biological and genetic properties of SAa88a88-14-2, a live-attenuated Japanese encephalitis vaccine that is currently available for humans. (22923123)
2012
17
Japanese encephalitis virus NS1' protein depends on pseudoknot secondary structure and is cleaved by caspase during virus infection and cell apoptosis. (22504173)
2012
18
Impact of weather variables on mosquitoes infected with Japanese encephalitis virus in Kurnool district, Andhra Pradesh. (22546646)
2012
19
Clinical development of IMOJEV Ar--a recombinant Japanese encephalitis chimeric vaccine (JE-CV). (22775524)
2012
20
Epidemiology of Japanese encephalitis in South Korea, 2007-2010. (22497964)
2012
21
A novel mutation (S227T) in domain II of the envelope gene of Japanese encephalitis virus circulating in North India. (20727244)
2011
22
Preexisting Japanese encephalitis virus neutralizing antibodies and increased symptomatic dengue illness in a school-based cohort in Thailand. (21991398)
2011
23
Baculovirus surface display of E envelope glycoprotein of Japanese encephalitis virus and its immunogenicity of the displayed proteins in mouse and swine models. (21115062)
2011
24
New Japanese encephalitis vaccines: alternatives to production in mouse brain. (21434803)
2011
25
Enhanced protection of mice against Japanese encephalitis virus infection by combinations of monoclonal antibodies to glycoprotein E. (21692566)
2011
26
Chemotherapy in Japanese encephalitis: are we there yet? (21488831)
2011
27
Multiple amino acid variations in the nonstructural proteins of swine Japanese encephalitis virus alter its virulence in mice. (21161554)
2011
28
Identification of a mutated BHK-21 cell line that became less susceptible to Japanese encephalitis virus infection. (21396132)
2011
29
Mutation of putative N-linked glycosylation sites in Japanese encephalitis virus premembrane and envelope proteins enhances humoral immunity in BALB/C mice after DNA vaccination. (21439032)
2011
30
Japanese encephalitis in two children--United States, 2010. (21389931)
2011
31
Isolation and molecular characterization of genotype 1 Japanese encephalitis virus, SX09S-01, from pigs in China. (21999532)
2011
32
Japanese encephalitis virus remains an important cause of encephalitis in Thailand. (20674433)
2010
33
Field evaluation of commercial immunoglobulin M antibody capture ELISA diagnostic tests for the detection of Japanese encephalitis virus infection among encephalitis patients in Nepal. (20346721)
2010
34
Co-expression of Japanese encephalitis virus prM-E-NS1 antigen with granulocyte-macrophage colony-stimulating factor enhances humoral and anti-virus immunity after DNA vaccination. (20064558)
2010
35
Involvement of ceramide in the propagation of Japanese encephalitis virus. (20053738)
2010
36
Immunomodulatory cytokines determine the outcome of Japanese encephalitis virus infection in mice. (20029807)
2010
37
Overview: Japanese encephalitis. (20132860)
2010
38
Mosquito distribution and Japanese encephalitis virus infection in the immigration bird (Asian open-billed stork) nested area in Pathum Thani province, central Thailand. (20155371)
2010
39
Japanese encephalitis in travelers: review of cases and seasonal risk. (19538584)
2009
40
Live chimeric and inactivated Japanese encephalitis virus vaccines differ in their cross-protective values against Murray Valley encephalitis virus. (19109382)
2009
41
Understanding the molecular mechanism of blood-brain barrier damage in an experimental model of Japanese encephalitis: correlation with minocycline administration as a therapeutic agent. (19628016)
2009
42
Status of natural infection with Japanese encephalitis virus in Japan: prevalence of antibodies to the nonstructural 1 protein among humans and horses. (19799840)
2009
43
Expression of Japanese encephalitis virus envelope protein in transgenic tobacco plants. (19628009)
2009
44
Bacterially expressed recombinant envelope protein domain III of Japanese encephalitis virus (rJEV-DIII) elicits Th1 type of immune response in BALB/c mice. (19761840)
2009
45
Tumor necrosis factor receptor-1-induced neuronal death by TRADD contributes to the pathogenesis of Japanese encephalitis. (17666051)
2007
46
Association of Japanese encephalitis virus NS3 protein with microtubules and tumour susceptibility gene 101 (TSG101) protein. (13679614)
2003
47
Gianotti-Crosti syndrome following Japanese encephalitis vaccination. (12808342)
2003
48
Acute transverse myelitis after Japanese B encephalitis vaccination in a 4-year-old girl. (11934518)
2002
49
Effect of cytokines on Japanese encephalitis virus production by human monocytes. (2118221)
1990
50
Antigenic relationships of the West Nile, Japanese B encephalitis, and St. Louis encephalitis viruses. (21018826)
1946

Genetic Variations for Japanese Encephalitis

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Expression for genes affiliated with Japanese Encephalitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Japanese Encephalitis

Search GEO for disease gene expression data for Japanese Encephalitis.

Pathways for genes affiliated with Japanese Encephalitis

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29KEGG, 53Reactome
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Pathways related to Japanese Encephalitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.1RSAD2, CXCL10, TYK2, IVNS1ABP, DDX58, FADD
2
Hide members
10.1IFIT2, FADD, DDX58, DDX58, TYK2, TXN

Compounds for genes affiliated with Japanese Encephalitis

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44Novoseek, 11DrugBank, 24HMDB
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Compounds related to Japanese Encephalitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1cycloheximide4410.4TAT, CXCL10
2poly(i-c)4410.4RSAD2, CXCL10, DDX58
3adenine44 11 2412.3TAT, CXCL10, HELLS
4retinoic acid44 2411.0TXN, HELLS, DDX58, TYK2, CXCL10, TAT
5iodoacetate4410.0PTS, TXN
6serine449.9TXN, RP9, HELLS, FADD, TYK2, TAT

GO Terms for genes affiliated with Japanese Encephalitis

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16Gene Ontology
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Biological processes related to Japanese Encephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1modulation by virus of host morphology or physiologyGO:01904810.2RSAD2, IVNS1ABP, DDX58, FADD
2response to virusGO:00961510.1RSAD2, IVNS1ABP, DDX58, IFIT2
3defense response to virusGO:0516079.9IFIT2, FADD, CXCL10, RSAD2

Molecular functions related to Japanese Encephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055159.5NHP2L1, RP9, IFIT2, HELLS, FADD, DDX42

Products for genes affiliated with Japanese Encephalitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Japanese Encephalitis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet