JE
MCID: JPN002
MIFTS: 51

Japanese Encephalitis (JE) malady

Infectious, Neuronal categories

Summaries for Japanese Encephalitis

Sources:
8Disease Ontology, 3CDC, 64Wikipedia, 33MalaCards
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CDC:3 Japanese encephalitis (JE) virus is the leading cause of vaccine-preventable encephalitis in Asia and the western Pacific. For most travelers to Asia, the risk for JE is very low but varies based on destination, duration of travel, season, and activities. JE virus is maintained in a cycle involving mosquitoes and vertebrate hosts, mainly pigs and wading birds. Humans can be infected when bitten by an infected mosquito. Most human infections are asymptomatic or result in only mild symptoms. However, a small percentage of infected persons develop inflammation of the brain (encephalitis), with symptoms including sudden onset of headache, high fever, disorientation, coma, tremors and convulsions. About 1 in 4 cases are fatal. There is no specific treatment for JE. Patient management focuses on supportive care and management of complications. Steps to prevent JE include using personal protective measures to prevent mosquito bites and vaccination.

MalaCards: Japanese Encephalitis, also known as japanese b encephalitis, is related to tick-borne encephalitis and yellow fever, and has symptoms including headache, convulsions and coma. An important gene associated with Japanese Encephalitis is PTS (6-pyruvoyltetrahydropterin synthase), and among its related pathways are Influenza A and Immune System. The compounds cycloheximide and poly(i-c) have been mentioned in the context of this disorder. Affiliated tissues include brain, brain and kidney, and related mouse phenotype mortality/aging.

Disease Ontology:8 A viral infectious disease that results in infection located in brain, has material basis in japanese encephalitis virus, which is transmitted by culex tritaeniorhynchus mosquito bite. the infection has symptom headache, has symptom high fever, has symptom neck stiffness, has symptom stupor, has symptom disorientation, has symptom coma, has symptom tremors, has symptom convulsions, and has symptom spastic paralysis.

Wikipedia:64 Japanese encephalitis (Japanese: 日本脳炎, Nihon-nōen)—previously known as Japanese B... more...

Aliases & Classifications for Japanese Encephalitis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 49Orphanet, 61UMLS, 45Novoseek, 57SNOMED-CT, 35MeSH, 27ICD9CM, 40NCIt, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious
Anatomical: Neuronal


Characteristics (Orphanet epidemiological data):

49
japanese encephalitis:
Inheritance: Sporadic; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

japanese encephalitis 8 43 10 49 61
japanese b encephalitis 8
encephalitis japanese 45
je 43


External Ids:

Disease Ontology8 DOID:10844
MeSH35 D004672
ICD9CM27 062.0
NCIt40 C34577
MESH via Orphanet36 D004672
ICD10 via Orphanet26 A83.0
SNOMED-CT via Orphanet58 52947006
UMLS via Orphanet62 C0014057
ICD1025 A83.0

Related Diseases for Japanese Encephalitis

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Japanese Encephalitis:



Diseases related to japanese encephalitis

Clinical Features for Japanese Encephalitis

Sources:
8Disease Ontology
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Symptoms:

8 (show all 9)
  • headache
  • convulsions
  • coma
  • tremors
  • neck stiffness
  • high fever
  • stupor
  • disorientation
  • spastic paralysis

Drugs & Therapeutics for Japanese Encephalitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Japanese Encephalitis

Drug clinical trials:

Search ClinicalTrials for Japanese Encephalitis

Search NIH Clinical Center for Japanese Encephalitis

Search CenterWatch for Japanese Encephalitis

Genetic Tests for Japanese Encephalitis

Anatomical Context for Japanese Encephalitis

Sources:
14FMA, 33MalaCards
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MalaCards organs/tissues related to Japanese Encephalitis:

33
Brain, Kidney, Spleen, Bone marrow, Myeloid, Monocytes, Nk cells, T cells, B cells, Endothelial, Fetal brain

FMA organs/tissues related to Japanese Encephalitis:

14
Brain

Animal Models for Japanese Encephalitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Japanese Encephalitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107689.8PTS, IFIT2, HELLS, FADD, DDX58, IVNS1ABP

Publications for Japanese Encephalitis

Sources:
51PubMed
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Articles related to Japanese Encephalitis:

(show top 50)    (show all 554)
idTitleAuthorsYear
1
Regulated IRE1-dependent decay pathway is activated during Japanese encephalitis virus-induced unfolded protein response and benefits viral replication. (24114795)
2014
2
Recovery of a chemically synthesized Japanese encephalitis virus revealed two critical adaptive mutations in NS2B and NS4A. (24362961)
2013
3
Characterization of immune responses induced by inactivated, live attenuated and DNA vaccines against Japanese encephalitis virus in mice. (23845821)
2013
4
Antibodies generated by immunization with the NS1 protein of West Nile virus confer partial protection against lethal Japanese encephalitis virus challenge. (23834965)
2013
5
Is a booster dose necessary in children after immunization with live attenuated Japanese encephalitis vaccine? (23764540)
2013
6
Bispidine-amino acid conjugates act as a novel scaffold for the design of antivirals that block Japanese encephalitis virus replication. (23350007)
2013
7
Antibodies to H5 subtype avian influenza virus and Japanese encephalitis virus in northern pintails (Anas acuta) sampled in Japan. (24059097)
2013
8
Inhibition of Japanese encephalitis virus infection by flavivirus recombinant E protein domain III. (23709058)
2013
9
Southernmost Asia is the source of Japanese encephalitis virus (genotype 1) diversity from which the viruses disperse and evolve throughout Asia. (24069502)
2013
10
Dengue virus and Japanese encephalitis virus epidemiological shifts in Nepal: a case of opposing trends. (23419366)
2013
11
Griffithsin inhibits Japanese encephalitis virus infection in vitro and in vivo. (23053519)
2013
12
Molecular characterization of Japanese encephalitis virus strains prevalent in Chinese swine herds. (23388434)
2013
13
Secondary cervical dystonic tremor after Japanese encephalitis. (24249222)
2013
14
Reduced neutralizing antibody titer against genotype I virus in swine immunized with a live-attenuated genotype III Japanese encephalitis virus vaccine. (23415032)
2013
15
Larvicidal activity of Saponin isolated from Gymnema sylvestre R. Br. (Asclepiadaceae) against Japanese Encephalitis vector, Culex tritaeniorhynchus Giles (Diptera: Culicidae). (23740457)
2013
16
Complete Genome of a Genotype I Japanese Encephalitis Virus Isolated from a Patient with Encephalitis in Vientiane, Lao PDR. (23469339)
2013
17
Matrix metalloproteinases and their tissue inhibitors in serum and cerebrospinal fluid of children with Japanese encephalitis virus infection. (23836397)
2013
18
Epidemiological concordance of Japanese encephalitis virus infection among mosquito vectors, amplifying hosts and humans in India. (22361257)
2013
19
Retrospective screening of serum and cerebrospinal fluid samples from patients with acute meningo-encephalitis does not reveal past Japanese encephalitis virus infection, Emilia Romagna, Italy, 2011. (22958609)
2012
20
Effect of the methyltransferase domain of Japanese encephalitis virus NS5 on the polymerase activity. (22285573)
2012
21
Comparison of performance of serum and plasma in panbio dengue and Japanese encephalitis virus enzyme-linked immunosorbent assays. (22826488)
2012
22
Upregulated expression of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in BALB/c mouse brain challenged with Japanese encephalitis virus. (22441541)
2012
23
Japanese encephalitis virus structural and nonstructural proteins expressed in Escherichia coli induce protective immunity in mice. (22001496)
2012
24
Serological and molecular diagnosis of Japanese encephalitis reveals an increasing public health problem in the state of West Bengal, India. (21993242)
2012
25
Time series analysis of Japanese encephalitis and weather in Linyi City, China. (21308477)
2012
26
Broad-spectrum antiviral activity of RNA interference against four genotypes of Japanese encephalitis virus based on single microRNA polycistrons. (22028851)
2011
27
Simultaneous detection and differentiation of dengue virus serotypes 1-4, Japanese encephalitis virus, and West Nile virus by a combined reverse-transcription loop-mediated isothermal amplification assay. (21777455)
2011
28
Japanese encephalitis virus co-opts the ER-stress response protein GRP78 for viral infectivity. (21418596)
2011
29
Comparison of the efficacy of CO2-baited and unbaited light traps, gravid traps, backpack aspirators, and sweep net collections for sampling mosquitoes infected with Japanese encephalitis virus. (21635643)
2011
30
Experimental infection of Japanese encephalitis virus in dogs. (21566398)
2011
31
Non-structural protein 1 (NS1) antibody-based assays to differentiate West Nile (WN) virus from Japanese encephalitis virus infections in horses: effects of WN virus NS1 antibodies induced by inactivated WN vaccine. (20974180)
2011
32
Emergence of Japanese encephalitis virus genotype V in the Republic of Korea. (21943222)
2011
33
Recommendations for use of a booster dose of inactivated vero cell culture-derived Japanese encephalitis vaccine: advisory committee on immunization practices, 2011. (21617632)
2011
34
A comparison of clinical features of Japanese encephalitis virus infection in the adult and pediatric age group with Acute Encephalitis Syndrome. (21715224)
2011
35
Involvement of cyclophilin B in the replication of Japanese encephalitis virus. (21281954)
2011
36
Serosurveillance for Japanese encephalitis and West Nile viruses in resident birds in Hawai'i. (20688669)
2010
37
Adverse event reports following Japanese encephalitis vaccination in the United States, 1999-2009. (20970488)
2010
38
Entacapone, a catechol-O-methyltransferase inhibitor, improves the motor activity and dopamine content of basal ganglia in a rat model of Parkinson's disease induced by Japanese encephalitis virus. (19879254)
2010
39
Minocycline differentially modulates macrophage mediated peripheral immune response following Japanese encephalitis virus infection. (20153075)
2010
40
Molecular epidemiology of Japanese encephalitis virus, Taiwan. (20409392)
2010
41
Virus-specific cytolytic antibodies to nonstructural protein 1 of Japanese encephalitis virus effect reduction of virus output from infected cells. (19264772)
2009
42
Ixiaro: a new vaccine against Japanese encephalitis. (19863241)
2009
43
Evaluation of IgM antibody capture enzyme-linked immunosorbent assay kits for detection of IgM against Japanese encephalitis virus in cerebrospinal fluid samples. (19996450)
2009
44
Trend of Japanese encephalitis in North India: evidence from thirty-eight acute encephalitis cases and appraisal of niceties. (19762970)
2009
45
Antibody responses induced by experimental West Nile virus infection with or without previous immunization with inactivated Japanese encephalitis vaccine in horses. (19652487)
2009
46
Evaluation of murine bone marrow-derived dendritic cells loaded with inactivated virus as a vaccine against Japanese encephalitis virus. (19665607)
2009
47
Cell-mediated immune responses in healthy children with a history of subclinical infection with Japanese encephalitis virus: analysis of CD4+ and CD8+ T cell target specificities by intracellular delivery of viral proteins using the human immunodeficiency virus Tat protein transduction domain. (14769905)
2004
48
Inhibition of Japanese encephalitis virus infection by diethyldithiocarbamate is independent of its antioxidant potential. (12856920)
2003
49
Persistent infection of mosquito cells grown in vitro with Murray Valley encephalitis and Japanese encephalitis viruses. (4386018)
1968
50
Simultaneous cultivation of epidemic typhus rickettsia and Japanese B encephalitis virus in the developing chick embryos. (14928403)
1952

Genetic Variations for Japanese Encephalitis

Expression for genes affiliated with Japanese Encephalitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Japanese Encephalitis

Search GEO for disease gene expression data for Japanese Encephalitis.

Pathways for genes affiliated with Japanese Encephalitis

Sources:
30KEGG, 54Reactome
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Pathways related to Japanese Encephalitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.1RSAD2, CXCL10, TYK2, IVNS1ABP, DDX58, FADD
2
Hide members
10.1IFIT2, FADD, DDX58, DDX58, TYK2, TXN

Compounds for genes affiliated with Japanese Encephalitis

Sources:
45Novoseek, 11DrugBank, 24HMDB
See all sources

Compounds related to Japanese Encephalitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1cycloheximide4510.4TAT, CXCL10
2poly(i-c)4510.4RSAD2, CXCL10, DDX58
3adenine45 11 2412.3TAT, CXCL10, HELLS
4retinoic acid45 2411.0TXN, HELLS, DDX58, TYK2, CXCL10, TAT
5iodoacetate4510.0PTS, TXN
6serine459.9TXN, RP9, HELLS, FADD, TYK2, TAT

GO Terms for genes affiliated with Japanese Encephalitis

Sources:
16Gene Ontology
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Biological processes related to Japanese Encephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1modulation by virus of host morphology or physiologyGO:01904810.2RSAD2, IVNS1ABP, DDX58, FADD
2response to virusGO:00961510.1RSAD2, IVNS1ABP, DDX58, IFIT2
3defense response to virusGO:0516079.9IFIT2, FADD, CXCL10, RSAD2

Molecular functions related to Japanese Encephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055159.5NHP2L1, RP9, IFIT2, HELLS, FADD, DDX42

Products for genes affiliated with Japanese Encephalitis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Japanese Encephalitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet