Japanese Encephalitis malady

CDC: Japanese encephalitis (JE) virus is the leading cause of vaccine-preventable encephalitis in Asia and the western Pacific. For most travelers to Asia, the risk for JE is very low but varies based on destination, duration of travel, season, and activities. JE virus is maintained in a cycle involving mosquitoes and vertebrate hosts, mainly pigs and wading birds. Humans can be infected when bitten by an infected mosquito. Most human infections are asymptomatic or result in only mild symptoms. However, a small percentage of infected persons develop inflammation of the brain (encephalitis), with symptoms including sudden onset of headache, high fever, disorientation, coma, tremors and convulsions. About 1 in 4 cases are fatal. There is no specific treatment for JE. Patient management focuses on supportive care and management of complications. Steps to prevent JE include using personal protective measures to prevent mosquito bites and vaccination.²

MalaCards: Japanese Encephalitis, also known as japanese b encephalitis, is related to hepatitis and west nile virus, and has symptoms including headache, high fever and neck stiffness. An important gene associated with Japanese Encephalitis is IGHV4-39 (immunoglobulin heavy variable 4-39), and among its related pathways are Colorectal cancer and RIG-I-like receptor signaling pathway. The compounds sp 600125 and n acetylcysteine have been mentioned in the context of this disorder. Affiliated tissues include brain, brain and t cells, and related mouse phenotypes are respiratory system and liver/biliary system.

Disease Ontology: A viral infectious disease that results in infection located in brain, has material basis in japanese encephalitis virus, which is transmitted by culex tritaeniorhynchus mosquito bite. the infection has symptom headache, has symptom high fever, has symptom neck stiffness, has symptom stupor, has symptom disorientation, has symptom coma, has symptom tremors, has symptom convulsions, and has symptom spastic paralysis.⁶

Wikipedia: Japanese encephalitis (Japanese: 日本脳炎, Nihon-nōen)—previously known as Japanese B...⁴⁴ more...

Aliases & Descriptions:

japanese encephalitis 6 30 8 43 japanese b encephalitis 6 encephalitis japanese 32

je 30

Diseases related to japanese encephalitis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 343)

id	Related Disease	Score	Top Affiliating Genes
1	hepatitis	28.5	IFNA1, TXN, TNFRSF1A, TAT, CXCL10
2	west nile virus	28.2	CD40LG, IVNS1ABP, IFNA1, SUPV3L1, RSAD2, HELLS
3	hepatitis c	27.1	JUN, CD40LG, IL4, IFNA1, IFNAR2, TXN
4	immunodeficiency	26.7	CD40LG, IL4, IFNA1, HSPA5, HSPA4, TNFRSF1A
5	parkinson's disease	26.6	MAPK14, CASP3, CASP8, CASP9, COMT, SOD1
6	cervicitis	21.7	JUN, IL4, MAPK14, IFNA1, IFNAR2, HSPA5
7	encephalitis	21.6	SENP8, RAF1, FUBP1, JUN, CD40LG, IVNS1ABP
8	astrocytoma	21.3	RAF1, JUN, IL4, MAPK14, AMFR, HSPA5
9	ischemia	21.2	RAF1, JUN, CD40LG, FADD, MAPK14, MAP3K5
10	cerebritis	20.6	RAF1, JUN, CD40LG, IL4, FADD, MAPK14
11	neuronitis	18.4	RAF1, FUBP1, JUN, CD40LG, IVNS1ABP, IL4
12	dengue disease	13.4	CD40LG, IVNS1ABP, HELLS
13	newcastle disease	13.3	IVNS1ABP, IFNA1, DDX58, CXCL10
14	thoracic cancer	13.3	CASP3, CASP8, CASP9
15	venezuelan equine encephalitis	13.2	IFNA1, TYK2, PRNT
16	hepatitis d	13.2	CD40LG, IGHV4-39, IFNA1
17	poliomyelitis	13.2	CD40LG, IL4, IGHV4-39, DPT
18	primary immunodeficiency disease	13.2	CD40LG, IL4, IGHV4-39
19	talipes equinovarus	13.1	CASP3, CASP8, CASP9
20	diphtheria	13.1	CD40LG, IGHV4-39, CASP3, DPT, TAT
21	cutaneous lupus erythematosus	13.1	CD40LG, IFNA1, SSB, CXCL10
22	cryptosporidiosis	13.1	CD40LG, IL4, CXCL10
23	guillain-barre syndrome	13.1	CD40LG, TNFRSF1A, ACP1, GFAP
24	hyperphenylalaninemia	13.1	PTS, TAT, SOD1
25	hepatitis e	13.0	CD40LG, IGHV4-39, IFNA1, HELLS, TSG101
26	mumps	13.0	CD40LG, FADD, IGHV4-39, IFNAR2, TNFRSF1A, DPT
27	kaposi's sarcoma	13.0	IFNA1, CASP8, TAT, CXCL10
28	immune defect due to absence of thymus	13.0	CD40LG, IL4, ACP1, TAT
29	galactosemia	13.0	F3, COMT, TAT, CP
30	autoimmune lymphoproliferative syndrome	13.0	FADD, CASP8, KRAS
31	subacute sclerosing panencephalitis	13.0	IL4, IGHV4-39, IFNA1, CXCL10
32	basaloid squamous cell skin carcinoma	13.0	IFNA1, CASP3, TXN
33	retinal ischemia	13.0	TXN, GFAP, SOD1
34	alexander disease	12.9	MAPK14, CASP3, GFAP
35	polycythemia vera	12.9	IFNA1, F3, PTS, ACP1, TYK2
36	typhus	12.9	CD40LG, IGHV4-39, F3
37	eales disease	12.8	IL4, SOD1, CP
38	ehrlichiosis	12.8	CD40LG, F3, CASP3
39	retinal vein occlusion	12.8	CD40LG, IL4, F3, CXCL10
40	brucellosis	12.8	CD40LG, IL4, IGHV4-39, IFNA1
41	avian influenza	12.8	IVNS1ABP, MAPK14, IFNA1, CXCL10
42	lymphoproliferative syndrome	12.8	CD40LG, FADD, CASP8, KRAS
43	lupus nephritis	12.8	CD40LG, FADD, IFNA1, CASP3, DDX58, CXCL10
44	letterer-siwe disease	12.8	IL4, FADD, IFNA1, CASP8
45	human immunodeficiency virus infectious disease	12.7	CD40LG, IL4, IGHV4-39, IFNA1, TAT
46	polycythemia	12.6	IFNA1, F3, CASP8, PTS, ACP1, TYK2
47	murray valley encephalitis	12.6	RAF1, PPP1R14B, KRAS
48	status epilepticus	12.6	JUN, CASP3, CASP9, GFAP
49	plasma cell leukemia	12.6	CD40LG, IFNA1, KRAS
50	acquired immunodeficiency syndrome	12.6	CD40LG, IFNA1, F3, TNFRSF1A, TAT

Symptoms: headache, high fever, neck stiffness, stupor, disorientation, coma, tremors, convulsions, spastic paralysis.⁶

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to japanese encephalitis:

²²

FMA organs/tissues related to japanese encephalitis:

¹¹

MGI Mouse Phenotypes related to japanese encephalitis:

²⁵ (show all 16)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.3	SUPV3L1, IVNS1ABP
2	liver/biliary system phenotype	MP:0005370	9.8	DDX58, SOD1, NPM1
3	hematopoietic system phenotype	MP:0005397	9.1	NPM1, TYK2, HELLS, KRAS, DDX58, SUPV3L1
4	endocrine/exocrine gland phenotype	MP:0005379	9.1	DNAJA1, KRAS, PTS, CASP8, CD40LG
5	tumorigenesis	MP:0002006	8.1	TSG101, KRAS, DDX58, TNFRSF1A, HSPA5, F3
6	embryogenesis phenotype	MP:0005380	7.7	COMT, KRAS, HELLS, TSG101, NPM1, SSB
7	mortality/aging	MP:0010768	7.6	DDX58, SSB, HELLS, GFAP, TYK2, TSG101
8	immune system phenotype	MP:0005387	7.3	COMT, KRAS, ACP1, GFAP, TYK2, CXCL10
9	integument phenotype	MP:0010771	7.0	KRAS, HELLS, TSG101, DPT, NPM1, SUPV3L1
10	nervous system phenotype	MP:0003631	6.6	COMT, KRAS, CXCL10, NPM1, CP, PTS
11	muscle phenotype	MP:0005369	6.6	SOD1, GFAP, KRAS, SUPV3L1, PTS, TNFRSF1A
12	vision/eye phenotype	MP:0005391	6.2	NHS, CP, NPM1, SOD1, DPT, GFAP
13	growth/size phenotype	MP:0005378	5.6	DDX58, KRAS, ACP1, HELLS, GFAP, TSG101
14	cardiovascular system phenotype	MP:0005385	5.0	PTS, SUPV3L1, COMT, KRAS, GFAP, CXCL10
15	homeostasis/metabolism phenotype	MP:0005376	4.8	PTS, DDX58, RSAD2, COMT, KRAS, HELLS
16	cellular phenotype	MP:0005384	3.0	CP, SUPV3L1, DDX58, RSAD2, KRAS, ACP1

Articles related to japanese encephalitis:

(show all 31)

id	Title	Authors	Year	Affiliating Genes
1	Association of heat-shock protein 70 with lipid rafts is required for Japanese encephalitis virus infection in Huh7 cells. (21940409)	Zhu Y.Z.... Qi Z.T.	2012	HSPA4
2	DnaJ homolog Hdj2 facilitates Japanese encephalitis v irus replication. (21999493)	Wang R.Y.... Chang R.Y.	2011	DNAJA1
3	Japanese encephalitis virus co-opts the ER-stress res ponse protein GRP78 for viral infectivity. (21418596)	Wu Y.P.... Wang R.Y.	2011	HSPA5
4	Heterogeneous nuclear ribonucleoprotein A2 participat es in the replication of Japanese encephalitis virus through an interaction wit h viral proteins and RNA. (21865391)	Katoh H.... Matsuura Y.	2011	HNRNPA2B1
5	FUSE binding protein 1 interacts with untranslated re gions of Japanese encephalitis virus RNA and negatively regulates viral replica tion. (21367899)	Chien H.L.... Lin Y.L.	2011	FUBP1
6	La protein can simultaneously bind to both 3'- and 5' -noncoding regions of Japanese encephalitis virus genome. (21294637)	Vashist S.... Vrati S.	2011	SSB
7	Entacapone, a catechol-O-methyltransferase inhibitor, improves the motor activity and dopamine content of basal ganglia in a rat mod el of Parkinson's disease induced by Japanese encephalitis virus. (19879254)	Hamaue N.... Aoki T.	2010	COMT
8	Japanese encephalitis virus down-regulates thioredoxi n and induces ROS-mediated ASK1-ERK/p38 MAPK activation in human promonocyte ce lls. (20430109)	Yang T.C.... Lin C.W.	2010	MAPK14, MAP3K5, TXN
9	Structure-based virtual screening for novel inhibitor s of Japanese encephalitis virus NS3 helicase/nucleoside triphosphatase. (19863664)	Kaczor A.... Matosiuk D.	2010	HELLS
10	Virus-specific cytolytic antibodies to nonstructural protein 1 of Japanese encephalitis virus effect reduction of virus output from infected cells. (19264772)	Krishna V.D.... Satchidanandam V.	2009	IVNS1ABP
11	La protein binds the predicted loop structures in the 3' non-coding region of Japanese encephalitis virus genome: role in virus repl ication. (19264640)	Vashist S.... Vrati S.	2009	SSB
12	Japanese encephalitis virus NS2B-NS3 protease induces caspase 3 activation and mitochondria-mediated apoptosis in human medulloblast oma cells. (19463724)	Yang T.C.... Lin C.W.	2009	CASP3
13	The cellular antiviral protein viperin is attenuated by proteasome-mediated protein degradation in Japanese encephalitis virus-infected cells. (18768981)	Chan Y.L.... Lin Y.L.	2008	RSAD2
14	Interferon antagonist function of Japanese encephalitis virus NS4A and its interaction with DEAD-box RNA helicase DDX42. (18588927)	Lin C.W.... Kao M.C.	2008	DDX42
15	Japanese encephalitis virus differentially modulates the induction of multiple pro-inflammatory mediators in human astrocytoma and astroglioma cell-lines. (18801452)	Mishra M.K.... Basu A.	2008	CP, GFAP, TXN
16	Japanese encephalitis virus infection activates caspase-8 and -9 in a FADD-independent and mitochondrion-dependent manner. (18632964)	Tsao C.H.... Liao C.L.	2008	CASP8, CASP9, FADD
17	Induction of IP-10 (CXCL10) in astrocytes following Japanese encephalitis. (17287085)	Bhowmick S.... Basu A.	2007	CXCL10
18	Tumor necrosis factor receptor-1-induced neuronal death by TRADD contributes to the pathogenesis of Japanese encephalitis. (17666051)	Swarup V.... Basu A.	2007	TNFRSF1A
19	Japanese encephalitis virus NS2B-NS3 protease binding to phage-displayed human brain proteins with the domain of trypsin inhibitor and basic region leucine zipper. (16289409)	Lin C.W.... Chen W.J.	2006	JUN
20	Blocking of interferon-induced Jak-Stat signaling by Japanese encephalitis virus NS5 through a protein tyrosine phosphatase-mediated mechanism. (16731929)	Lin R.J.... Lin Y.L.	2006	TYK2, ACP1, PTS
21	Nucleolar protein B23 interacts with Japanese encephalitis virus core protein and participates in viral replication. (16547420)	Tsuda Y.... Matsuura Y.	2006	NPM1
22	Polymorphisms of the gene coding for copper/zinc superoxide dismutase (SOD1) in patients with Japanese encephalitis. (16989689)	Thuong N.T.... Farrar J.J.	2006	SOD1
23	Identification of Japanese encephalitis virus-inducible genes in mouse brain and characterization of GARG39/IFIT2 as a microtubule-associated protein. (17030862)	Saha S.... Rangarajan P.N.	2006	IFIT2
24	An increase of blood anti-beta2-glycoprotein I antibody in Japanese encephalitis associated with cerebral ischemia. (15650547)	Chen W.H.... Liu J.S.	2005	F3
25	Cell-mediated immune responses in healthy children with a history of subclinical infection with Japanese encephalitis virus: analysis of CD4+ and CD8+ T cell target specificities by intracellular delivery of viral proteins using the human immunodeficiency virus Tat protein transduction domain. (14769905)	Kumar P.... Satchidanandam V.	2004	TAT
26	Development and evaluation of an enzyme-linked immunosorbent assay for quantifying antibodies to Japanese encephalitis virus nonstructural 1 protein to detect subclinical infections in vaccinated horses. (15528700)	Konishi E.... Kondo T.	2004	IVNS1ABP
27	Proinflammatory cytokines and chemokines in humans wi th Japanese encephalitis. (15478067)	Winter P.M.... Solomon T.	2004	IL4
28	Association of Japanese encephalitis virus NS3 protein with microtubules and tumour susceptibility gene 101 (TSG101) protein. (13679614)	Chiou C.T.... Wang J.J.	2003	TSG101
29	Ring-expanded ('fat') nucleoside and nucleotide analogues exhibit potent in vitro activity against flaviviridae NTPases/helicases, including those of the West Nile virus, hepatitis C virus, and Japanese encephalitis virus. (12954067)	Zhang N.... Borowski P.	2003	HELLS
30	Antibody to the nonstructural protein NS1 of Japanese encephalitis virus: potential application of mAb-based indirect ELISA to differentiate infection from vaccination. (11166901)	Shu P.Y.... Huang J.H.	2001	IVNS1ABP
31	Rapid diagnosis of Japanese encephalitis by using an immunoglobulin M dot enzyme immunoassay. (9650956)	Solomon T.... Cardosa M.J.	1998	CD40LG

Genes related to japanese encephalitis according to GeneCards:

(show top 50)    (show all 52)

id	Symbol	Description	Score	GeneCards Section Context
1	IGHV4-39	immunoglobulin heavy variable 4-39	11.0
2	PPP1R14B	protein phosphatase 1, regulatory (inhibitor) subunit 14B	11.0
3	PRNT	prion protein (testis specific)	11.0
4	IFIT2	interferon-induced protein with tetratricopeptide repeats 2	11.0	Publications
5	RSAD2	radical S-adenosyl methionine domain containing 2	11.0	Publications
6	SSB	Sjogren syndrome antigen B (autoantigen La)	11.0	Publications
7	SENP8	SUMO/sentrin specific peptidase family member 8	11.0
8	RP9	retinitis pigmentosa 9 (autosomal dominant)	11.0
9	TUBE1	tubulin, epsilon 1	11.0
10	IVNS1ABP	influenza virus NS1A binding protein	11.0	Publications
11	DPT	dermatopontin	11.0
12	NHP2L1	NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)	11.0
13	EDEM3	ER degradation enhancer, mannosidase alpha-like 3	11.0
14	FADD	Fas (TNFRSF6)-associated via death domain	11.0	Publications
15	FUBP1	far upstream element (FUSE) binding protein 1	11.0	Publications
16	PTS	6-pyruvoyltetrahydropterin synthase	11.0	Publications
17	DNAJA1	DnaJ (Hsp40) homolog, subfamily A, member 1	11.0	Publications
18	TYK2	tyrosine kinase 2	11.0	Publications
19	DDX42	DEAD (Asp-Glu-Ala-Asp) box polypeptide 42	11.0	Publications
20	DDX58	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58	11.0	Functions
21	TSG101	tumor susceptibility gene 101	11.0	Publications
22	CXCL10	chemokine (C-X-C motif) ligand 10	11.0	Publications
23	TXN	thioredoxin	11.0	Publications
24	PHKA2	phosphorylase kinase, alpha 2 (liver)	11.0
25	IFNAR2	interferon (alpha, beta and omega) receptor 2	11.0
26	AMFR	autocrine motility factor receptor, E3 ubiquitin protein ligase	11.0
27	HNRNPA2B1	heterogeneous nuclear ribonucleoprotein A2/B1	11.0	Publications
28	HELLS	helicase, lymphoid-specific	11.0	Publications
29	TAT	tyrosine aminotransferase	11.0	Publications
30	SUPV3L1	suppressor of var1, 3-like 1 (S. cerevisiae)	11.0
31	NHS	Nance-Horan syndrome (congenital cataracts and dental anomalies)	11.0
32	NPM1	nucleophosmin (nucleolar phosphoprotein B23, numatrin)	11.0	Publications
33	TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	11.0	Publications
34	ACP1	acid phosphatase 1, soluble	11.0	Publications
35	MAP3K5	mitogen-activated protein kinase kinase kinase 5	11.0	Publications
36	HSPA5	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	11.0	Publications
37	CP	ceruloplasmin (ferroxidase)	11.0	Publications
38	CASP9	caspase 9, apoptosis-related cysteine peptidase	11.0	Publications
39	GFAP	glial fibrillary acidic protein	11.0	Publications
40	COMT	catechol-O-methyltransferase	11.0	Publications
41	CD40LG	CD40 ligand	11.0	Publications
42	CASP8	caspase 8, apoptosis-related cysteine peptidase	11.0	Publications
43	CASP3	caspase 3, apoptosis-related cysteine peptidase	11.0	Publications
44	F3	coagulation factor III (thromboplastin, tissue factor)	11.0	Publications
45	SOD1	superoxide dismutase 1, soluble	11.0	Publications
46	IFNA1	interferon, alpha 1	11.0	Publications
47	MAPK14	mitogen-activated protein kinase 14	11.0	Publications
48	JUN	jun proto-oncogene	11.0	Publications
49	IL4	interleukin 4	11.0	Publications
50	HSPA4	heat shock 70kDa protein 4	11.0	Publications

Pathways related to japanese encephalitis according to GeneDecks:

(show top 50)    (show all 80)

id	Pathway	Score	Top Affiliating Genes
1	Colorectal cancer20	10.6	CASP9
2	RIG-I-like receptor signaling pathway20	10.2	FADD, CASP8, DDX58, CXCL10
3	all-trans-Retinoic Acid Mediated Apoptosis36	10.2	CASP8, CASP9, FADD
4	Caspase Cascade36	10.1	FADD, TNFRSF1A
5	Immune response_IFN alpha/beta signaling pathway41	10.0	TYK2, IFIT2, IFNAR2, IFNA1
6	DR3 Signaling36	9.9	CASP9, CASP8, CASP3, FADD
7	Immune response IFN alpha/beta signaling pathway10	9.8	TYK2, IFNAR2, IFNA1, IFIT2
8	TWEAK Pathway36	9.8	CASP9, FADD, CASP3, CASP8
9	Apoptotic Pathways Triggered By HIV136	9.8	TNFRSF1A, CASP9, MAP3K5, CASP3, FADD
10	Apoptosis and survival Caspase cascade10	9.8	CASP3, FADD, CASP8, CASP9, TNFRSF1A
11	TRAIL Pathway36	9.8	FADD, CASP8, CASP9, CASP3
12	Apoptosis and survival_Caspase cascade41	9.8	FADD, CASP3, CASP8, TNFRSF1A, CASP9
13	Apoptosis and survival Apoptotic TNF-family pathways10	9.7	TNFRSF1A, CASP3, CASP9, FADD, CASP8
14	Apoptosis and survival_Apoptotic TNF-family pathways41	9.7	TNFRSF1A, FADD, CASP3, CASP9, CASP8
15	Apoptosis and survival_FAS signaling cascades41	9.7	MAP3K5, CASP3, FADD, CASP9, CASP8
16	Apoptosis and survival FAS signaling cascades10	9.7	FADD, MAP3K5, CASP9, CASP3, CASP8
17	Apoptosis through Death Receptors36	9.6	MAP3K5, FADD, CASP3, CASP8, CASP9, TNFRSF1A
18	Apoptosis20	9.4	FADD, CASP3, CASP9, TNFRSF1A, CASP8
19	Apoptosis and Autophagy3	9.4	TNFRSF1A, TXN, FADD, MAP3K5, CASP3, CASP8
20	TNFR1 Pathway36	9.4	FADD, CASP3, CASP8, CASP9, TNFRSF1A, JUN
21	Apoptosis and survival_TNFR1 signaling pathway41	9.3	FADD, CASP3, CASP8, CASP9, JUN, TNFRSF1A
22	Apoptosis and survival TNFR1 signaling pathway10	9.3	TNFRSF1A, CASP9, JUN, CASP8, FADD, CASP3
23	Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)41	9.3	CP, HSPA4, SOD1, HSPA5
24	UVA-Induced MAPK Signaling36	9.3	MAPK14, JUN, CASP3, CASP8
25	CTL Mediated Apoptosis36	9.3	CASP8, CASP9, FADD, CASP3
26	Amyotrophic lateral sclerosis (ALS)20	9.2	TNFRSF1A, MAPK14, MAP3K5, CASP3, CASP9, SOD1
27	Apoptosis Signaling Pathways37	9.2	FADD, CASP3, HSPA4, CASP8, CASP9, TNFRSF1A
28	Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins10	9.1	RAF1, CASP8, CASP9, TNFRSF1A
29	Toxoplasmosis20	9.1	CASP3, MAPK14, CD40LG, TYK2, CASP8, TNFRSF1A
30	Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins41	9.1	CASP8, CASP9, TNFRSF1A, RAF1
31	Endothelin-1 Signaling Pathway36	9.1	IL4, CXCL10, RAF1, CASP3
32	Toll-like receptor signaling pathway20	9.0	CXCL10, IFNA1, JUN, FADD, MAPK14, CASP8
33	TRAF Pathway36	9.0	JUN, FADD, CASP3, CASP8, TNFRSF1A, MAP3K5
34	TNF Superfamily Pathway36	8.9	JUN, FADD, MAPK14, CASP3, CASP8, CASP9
35	Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR241	8.9	MAP3K5, MAPK14, JUN, RAF1, TXN
36	Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR210	8.9	TXN, JUN, MAP3K5, MAPK14, RAF1
37	TNF Signaling36	8.8	JUN, FADD, MAPK14, MAP3K5, CASP3, CASP8
38	14-3-3 Induced Apoptosis36	8.8	CASP9, CASP8, CASP3, MAP3K5, MAPK14, TNFRSF1A
39	TRKA Signaling36	8.7	MAP3K5, JUN, RAF1, CASP9, CASP3
40	TNF-Induced Apoptosis Implicating Sphingolipids36	8.6	CASP9, CASP8, TNFRSF1A, CASP3, MAPK14, RAF1
41	Molecular Mechanisms of Cancer36	8.6	MAP3K5, TUBE1, CASP3, CASP8, FADD, JUN
42	Ceramide Pathway36	8.5	CASP9, CASP8, CASP3, FADD, JUN, RAF1
43	Fas Signaling36	8.5	JUN, RAF1, FADD, CASP3, CASP8, CASP9
44	G-protein signaling_Ras family GTPases in kinase cascades (scheme)41	8.5	RAF1, KRAS, MAPK14, JUN
45	G-protein signaling Ras family GTPases in kinase cascades (scheme)10	8.5	KRAS, MAPK14, JUN, RAF1
46	Hepatitis C20	8.2	IFNA1, MAPK14, RAF1, KRAS, IFNAR2, TNFRSF1A
47	Tuberculosis20	8.2	FADD, MAPK14, IFNA1, CASP3, CASP8, CASP9
48	MAP Kinase Signaling3	8.1	KRAS, MAP3K5, JUN, MAPK14, RAF1
49	T cell receptor signaling pathway20	7.8	RAF1, IL4, KRAS, MAPK14, CD40LG, JUN
50	Influenza A20	7.8	RAF1, JUN, IVNS1ABP, MAPK14, IFNA1, IFNAR2

Compounds related to japanese encephalitis according to GeneDecks:

(show top 50)    (show all 189)

id	Compound	Score	Top Affiliating Genes
1	sp 60012532 42	11.6	CASP3
2	n acetylcysteine32	9.9	RAF1, MAP3K5
3	h2o232	9.6	MAPK14, TYK2, MAP3K5, HELLS, CASP9, TNFRSF1A
4	trolox32	9.1	SOD1, ACP1, CASP3, MAPK14, CASP9, HSPA5
5	aspartate32	9.1	TAT, GFAP, NPM1, RAF1, CD40LG
6	ebselen32	9.1	TXN, SOD1, JUN, MAPK14, CASP9, MAP3K5
7	egcg32	9.0	SOD1, CASP9, MAPK14, RAF1
8	rottlerin32 42	9.9	JUN, CASP9, CASP8, MAPK14, CD40LG
9	sb 20358032 42	9.9	MAPK14, HSPA5, ACP1, CASP8, CASP3, HSPA4
10	selenite32	8.8	TXN, JUN, MAPK14, MAP3K5, CASP8, SOD1
11	threonine32	8.8	PTS, HELLS, RAF1, MAP3K5, CASP8
12	rapamycin32 42	9.7	RAF1, ACP1, KRAS, CASP9, MAP3K5
13	diphenyleneiodonium32	8.6	CASP9, SOD1, TAT, CASP3, MAPK14, ACP1
14	cd 43732	8.6	MAPK14, F3, CASP3, CASP9, CASP8, JUN
15	estrogen32	8.6	RAF1, MAP3K5, HSPA5, CP, COMT, ACP1
16	s-nitroso-n-acetylpenicillamine32	8.5	ACP1, CP, CASP9, HSPA4, CASP3, MAPK14
17	ly29400232	8.4	CASP3, MAPK14, MAP3K5, IL4, JUN, KRAS
18	camptothecin32 42 9 9	11.4	CASP9, NPM1, HSPA5, CASP8, CASP3, HSPA4
19	adriamycin32	8.2	CASP9, CASP8, IFNA1, TXN, TSG101, SOD1
20	c2ceramide32	8.2	JUN, TNFRSF1A, CASP8, CASP3, HSPA4, MAPK14
21	15-deoxy-delta-12,14-prostaglandin j232	7.9	JUN, IL4, HSPA4, MAPK14, TXN, CASP3
22	cyclosporin a32 42	8.7	TAT, TNFRSF1A, TXN, ACP1, IFNA1, IL4
23	alanine32	7.5	IFNA1, NPM1, IFNAR2, CD40LG, RAF1, F3
24	ascorbic acid32 18	8.4	PTS, RAF1, CD40LG, CP, SOD1, ACP1
25	chloroquine32 34 9 9	10.4	CXCL10, TAT, TNFRSF1A, IFNA1, IL4, RAF1
26	lactacystin32	7.4	CASP8, CASP3, HSPA4, HSPA5, MAPK14, RAF1
27	adenylate32	7.3	MAPK14, HSPA4, TXN, IL4, IVNS1ABP, ACP1
28	superoxide32 18	8.3	CP, MAPK14, MAP3K5, HSPA5, HSPA4, GFAP
29	resveratrol32 9 18 9	10.2	CASP9, CASP3, HSPA4, MAPK14, JUN, RAF1
30	curcumin32	7.2	RAF1, JUN, MAPK14, HSPA4, CASP3, ACP1
31	cysteine32	7.2	CASP8, CASP9, TXN, TNFRSF1A, COMT, HELLS
32	arsenite32 18	8.2	JUN, MAPK14, IFNA1, F3, HSPA5, CASP3
33	oxygen32 18	8.1	CASP8, MAPK14, CP, TAT, ACP1, GFAP
34	wortmannin32 42	8.0	CXCL10, RAF1, JUN, MAPK14, HSPA5, CASP3
35	pdtc32	7.0	CP, SOD1, CASP9, CASP8, CASP3, F3
36	indomethacin32 9 9	8.9	CD40LG, RAF1, CP, IL4, MAPK14, HSPA4
37	paclitaxel32 34 9 9	9.8	KRAS, HSPA4, GFAP, CASP8, CASP9, NPM1
38	quercetin32 42 9 18 9	10.6	JUN, RAF1, MAPK14, COMT, SOD1, GFAP
39	genistein32 9 18 9	9.6	HSPA5, CASP3, RAF1, ACP1, JUN, CD40LG
40	butyrate32	6.6	RAF1, TAT, GFAP, ACP1, KRAS, CASP9
41	vegf32	6.5	TNFRSF1A, CP, TAT, RAF1, AMFR, F3
42	phosphatidylinositol32	6.4	RAF1, MAPK14, CASP9, CASP8, JUN, CXCL10
43	cisplatin32 34 9 9	9.3	KRAS, ACP1, TNFRSF1A, TXN, HELLS, GFAP
44	doxorubicin32 34 9 9	9.3	MAPK14, RAF1, CD40LG, FADD, MAP3K5, IFNA1
45	actinomycin d32	6.2	FADD, TXN, CASP9, CASP8, CASP3, HSPA4
46	dexamethasone32 42 34 9 9	9.6	IL4, ACP1, CASP9, CASP8, HSPA4, IFNA1
47	tyrosine32	5.1	TNFRSF1A, NPM1, PHKA2, KRAS, ACP1, HELLS
48	cycloheximide32	4.9	NPM1, IL4, FADD, MAPK14, IFNA1, F3
49	serine32	4.2	CASP3, CASP8, CASP9, TXN, HSPA4, HSPA5
50	retinoic acid32 42 18	5.9	KRAS, ACP1, HELLS, GFAP, TYK2, TAT

Cellular components related to japanese encephalitis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cell body	GO:044297	9.9	FADD, CASP8, GFAP
2	mitochondrion	GO:005739	7.4	SOD1, TAT, KRAS, COMT, RSAD2, SUPV3L1
3	cytosol	GO:005829	5.5	RAF1, SOD1, TAT, TYK2, GFAP, PHKA2

Biological processes related to japanese encephalitis according to GeneDecks:

(show all 7)

id	Name	GO ID	Score	Top Affiliating Genes
1	response to virus	GO:009615	9.7	RSAD2, DDX58, IFNAR2, IFIT2, IVNS1ABP
2	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:006919	9.6	FADD, MAP3K5, F3, CASP8
3	induction of apoptosis by extracellular signals	GO:008624	9.4	TNFRSF1A, CASP8, CASP3, MAP3K5, FADD
4	virus-host interaction	GO:019048	9.4	NPM1, RSAD2, DDX58, TNFRSF1A, CASP8, MAP3K5
5	response to lipopolysaccharide	GO:032496	9.0	JUN, CXCL10, COMT, TNFRSF1A, CASP8, F3
6	anti-apoptosis	GO:006916	8.9	NPM1, SOD1, SUPV3L1, HSPA5, F3, CD40LG
7	innate immune response	GO:045087	8.8	RSAD2, DDX58, TXN, CASP8, MAP3K5, MAPK14

Molecular functions related to japanese encephalitis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	3.8	RAF1, TXN, TNFRSF1A, SUPV3L1, DDX42, DDX58