JE
MCID: JPN002
MIFTS: 55

Japanese Encephalitis (JE) malady

Infectious diseases, Neuronal diseases categories

Summaries for Japanese Encephalitis

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8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
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CDC:3 Japanese encephalitis (JE) virus is the leading cause of vaccine-preventable encephalitis in Asia and the western Pacific. For most travelers to Asia, the risk for JE is very low but varies based on destination, duration of travel, season, and activities. JE virus is maintained in a cycle involving mosquitoes and vertebrate hosts, mainly pigs and wading birds. Humans can be infected when bitten by an infected mosquito. Most human infections are asymptomatic or result in only mild symptoms. However, a small percentage of infected persons develop inflammation of the brain (encephalitis), with symptoms including sudden onset of headache, high fever, disorientation, coma, tremors and convulsions. About 1 in 4 cases are fatal. There is no specific treatment for JE. Patient management focuses on supportive care and management of complications. Steps to prevent JE include using personal protective measures to prevent mosquito bites and vaccination.

MalaCards: Japanese Encephalitis, also known as japanese b encephalitis, is related to encephalitis and tick-borne encephalitis, and has symptoms including spastic paralysis, high fever and neck stiffness. An important gene associated with Japanese Encephalitis is PTS (6-pyruvoyltetrahydropterin synthase), and among its related pathways are Influenza A and Immune System. The compounds cycloheximide and poly(i-c) have been mentioned in the context of this disorder. Affiliated tissues include brain, brain and b cells, and related mouse phenotype mortality/aging.

Disease Ontology:8 A viral infectious disease that results in infection located in brain, has material basis in japanese encephalitis virus, which is transmitted by culex tritaeniorhynchus mosquito bite. the infection has symptom headache, has symptom high fever, has symptom neck stiffness, has symptom stupor, has symptom disorientation, has symptom coma, has symptom tremors, has symptom convulsions, and has symptom spastic paralysis.

Wikipedia:63 Japanese encephalitis (Japanese: 日本脳炎, Nihon-nōen)—previously known as Japanese B... more...

Aliases & Classifications for Japanese Encephalitis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 60UMLS, 44Novoseek, 56SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
japanese encephalitis:
Inheritance: Sporadic; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

japanese encephalitis 8 42 10 48 60
japanese b encephalitis 8
encephalitis japanese 44
je 42


External Ids:

Disease Ontology8 DOID:10844
MeSH34 D004672
ICD9CM27 062.0
NCIt39 C34577
MESH via Orphanet35 D004672
ICD10 via Orphanet26 A83.0
SNOMED-CT via Orphanet57 52947006
UMLS via Orphanet61 C0014057
ICD1025 A83.0

Related Diseases for Japanese Encephalitis

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17GeneCards, 18GeneDecks
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Diseases related to Japanese Encephalitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 61)
idRelated DiseaseScoreTop Affiliating Genes
1encephalitis32.0TAT, CXCL10
2tick-borne encephalitis30.4TUBE1
3yellow fever30.3PRNT
4dengue hemorrhagic fever29.9IVNS1ABP
5hepatitis29.9TAT, CXCL10, TXN
6influenza29.9TXN, DDX58, IVNS1ABP, CXCL10, TAT
7hepatitis c29.9CXCL10, HELLS, TXN
8astrocytoma29.9TAT, CXCL10
9viral encephalitis10.7
10west nile encephalitis10.7
11neuronitis10.4
12murray valley encephalitis10.4
13louping ill10.3
14encephalomyelitis10.2
15neuroblastoma10.2
16myelitis10.1
17cerebritis10.1
18chikungunya10.1
19hemiplegia10.1
20medulloblastoma10.1
21meningitis10.1
22epidemic typhus10.1
23typhus10.1
24newcastle disease10.0IVNS1ABP, CXCL10
25ebola hemorrhagic fever10.0DDX58, IFIT2
26sarcoma10.0TAT, FADD, HELLS
27tyrosinemia10.0TAT
28atherosclerosis10.0TXN, CXCL10, PTS
29hepatitis b10.0TAT, CXCL10, FADD, TXN
30viral infectious disease10.0TXN, HELLS, DDX58, IVNS1ABP, CXCL10, TAT
31ipex syndrome10.0TXN, HELLS, IVNS1ABP, CXCL10, TAT, PTS
32hyperphenylalaninemia10.0PTS
33ovarian cancer10.0HELLS, TXN
34dengue disease10.0IVNS1ABP, HELLS
35parkinson's disease10.0
36rift valley fever10.0
37neuromyelitis optica10.0
38kunjin encephalitis10.0
39avian influenza10.0
40visceral leishmaniasis10.0
41aseptic meningitis10.0
42west syndrome10.0
43west nile fever10.0
44st. louis encephalitis10.0
45western equine encephalitis10.0
46venezuelan equine encephalitis10.0
47acute disseminated encephalomyelitis10.0
48adult syndrome10.0
49basal ganglia disease10.0
50brain disease10.0

Graphical network of the top 20 diseases related to Japanese Encephalitis:



Diseases related to japanese encephalitis

Clinical Features for Japanese Encephalitis

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Sources:
8Disease Ontology
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Symptoms:

8 (show all 9)
  • spastic paralysis
  • high fever
  • neck stiffness
  • stupor
  • disorientation
  • coma
  • tremors
  • convulsions
  • headache

Drugs & Therapeutics for Japanese Encephalitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Japanese Encephalitis

Drug clinical trials:

Search ClinicalTrials for Japanese Encephalitis

Search NIH Clinical Center for Japanese Encephalitis

Search CenterWatch for Japanese Encephalitis

Genetic Tests for Japanese Encephalitis

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Anatomical Context for Japanese Encephalitis

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Japanese Encephalitis:

32
Brain, B cells, T cells, Testes, Endothelial, Kidney, Monocytes, Bone, Spleen, Myeloid

FMA organs/tissues related to Japanese Encephalitis:

14
Brain

Animal Models for Japanese Encephalitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Japanese Encephalitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107689.8PTS, IFIT2, HELLS, FADD, DDX58, IVNS1ABP

Publications for Japanese Encephalitis

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50PubMed
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Articles related to Japanese Encephalitis:

(show top 50)    (show all 554)
idTitleAuthorsYear
1
Production of single-round infectious chimeric flaviviruses with DNA-based Japanese encephalitis virus replicon. (24096319)
2014
2
High incidence of Japanese encephalitis, southern China. (23750863)
2013
3
Japanese encephalitis virus activates autophagy as a viral immune evasion strategy. (23320079)
2013
4
Japanese encephalitis: status of surveillance and immunization in Asia and the Western Pacific, 2012. (24040676)
2013
5
Surveillance of Japanese encephalitis virus infection in mosquitoes in Vietnam from 2006 to 2008. (23358634)
2013
6
RNA-dependent RNA polymerase of Japanese encephalitis virus binds the initiator nucleotide GTP to form a mechanistically important pre-initiation state. (24293643)
2013
7
Seasonal abundance and potential of Japanese encephalitis virus infection in mosquitoes at the nesting colony of ardeid birds, Thailand. (23620839)
2013
8
The first case of mild encephalopathy with a reversible splenial lesion due to Japanese encephalitis virus infection. (24136911)
2013
9
JE-ADVAX vaccine protection against Japanese encephalitis virus mediated by memory B cells in the absence of CD8(+) T cells and pre-exposure neutralizing antibody. (23388724)
2013
10
Clinical and radiological spectrum of Japanese encephalitis. (23260319)
2013
11
Molecular detection and genotyping of Japanese encephalitis virus in mosquitoes during a 2010 outbreak in the Republic of Korea. (23390520)
2013
12
A bio-nanocapsule containing envelope protein domain III of Japanese encephalitis virus protects mice against lethal Japanese encephalitis virus infection. (23773026)
2013
13
Cross-reactivity of chicken anti-Japanese encephalitis virus serum and anti-West Nile virus serum in serological diagnosis. (22785078)
2012
14
Immunogenicity of one dose of Vero cell culture-derived Japanese encephalitis (JE) vaccine in adults previously vaccinated with mouse brain-derived JE vaccine. (22406277)
2012
15
Development and application of an antigen capture ELISA assay for diagnosis of Japanese encephalitis virus in swine, human and mosquito. (22221768)
2012
16
Japanese encephalitis virus RNA detected in Culex pipiens mosquitoes in Italy. (22835438)
2012
17
A prospective assessment of the accuracy of commercial IgM ELISAs in diagnosis of Japanese encephalitis virus infections in patients with suspected central nervous system infections in Laos. (22764310)
2012
18
Replicon-based Japanese encephalitis virus vaccines elicit immune response in mice. (22108431)
2012
19
Superior immunogenicity of a freeze-dried, cell culture-derived Japanese encephalitis vaccine (inactivated). (22306856)
2012
20
MRI features of Japanese encephalitis. (22761224)
2012
21
Development of an in vitro antigen-detection test as an alternative method to the in vivo plaque reduction neutralization test for the quality control of Japanese encephalitis virus vaccine. (22486472)
2012
22
Impaired cross-presentation of CD8I++ CD11c+ dendritic cells by Japanese encephalitis virus in a TLR2/MyD88 signal pathway-dependent manner. (22706912)
2012
23
Characterization of Rabensburg virus, a flavivirus closely related to West Nile virus of the Japanese encephalitis antigenic group. (22724010)
2012
24
Kikuchi-Fujimoto disease following vaccination against human papilloma virus infection and Japanese encephalitis. (22476507)
2012
25
DnaJ homolog Hdj2 facilitates Japanese encephalitis virus replication. (21999493)
2011
26
Src signaling involvement in Japanese encephalitis virus-induced cytokine production in microglia. (21354239)
2011
27
Surface display of domain III of Japanese encephalitis virus E protein on Salmonella typhimurium by using an ice nucleation protein. (22160941)
2011
28
Japanese encephalitis virus genotype replacement, Taiwan, 2009-2010. (22172307)
2011
29
Serosurveillance for Japanese encephalitis virus infection among equines in India. (22122900)
2011
30
Nonstructural protein 1 antibody-based epitope-blocking enzyme-linked immunosorbent assay to differentiate Japanese encephalitis virus from dengue virus infections in humans. (21788702)
2011
31
A monoclonal antibody against PrM/M protein of Japanese encephalitis virus. (22008072)
2011
32
Pathogenesis of Japanese encephalitis virus infection in a golden hamster model and evaluation of flavivirus cross-protective immunity. (21540381)
2011
33
Identification of a heparin binding peptide from the Japanese encephalitis virus envelope protein. (20069543)
2010
34
Molecular evolution of Japanese encephalitis virus isolates from swine in Oita, Japan during 1980-2009. (20035900)
2010
35
Japanese encephalitis virus induces matrix metalloproteinase-9 in rat brain astrocytes via NF-I_B signalling dependent on MAPKs and reactive oxygen species. (20698853)
2010
36
Safety and immunogenicity of a single administration of live-attenuated Japanese encephalitis vaccine in previously primed 2- to 5-year-olds and naive 12- to 24-month-olds: multicenter randomized controlled trial. (20856164)
2010
37
Identification and characterization of Japanese encephalitis virus envelope protein gene from swine. (20477964)
2010
38
Evaluation of a dengue IgG indirect enzyme-linked immunosorbent assay and a Japanese encephalitis IgG indirect enzyme-linked immunosorbent assay for diagnosis of secondary dengue virus infection. (19874185)
2010
39
Japanese encephalitis disease burden and clinical features of Japanese encephalitis in four cities in the People's Republic of China. (20889863)
2010
40
Expression profile of Japanese encephalitis virus induced neuroinflammation and its implication in disease severity. (20637688)
2010
41
Minocycline differentially modulates viral infection and persistence in an experimental model of Japanese encephalitis. (20635157)
2010
42
Immunogenicity of an inactivated Japanese encephalitis vaccine (JE-VAX) in humans over 20 years at USAMRIID: using PRNT50 as an endpoint for immunogenicity. (20060946)
2010
43
Long term immunity to live attenuated Japanese encephalitis chimeric virus vaccine: randomized, double-blind, 5-year phase II study in healthy adults. (21150279)
2010
44
Dogs as sentinels for human infection with Japanese encephalitis virus. (20587189)
2010
45
Etiological spectrum of clinically diagnosed Japanese encephalitis cases reported in Guizhou Province, China, in 2006. (20147638)
2010
46
Genomic sequence of a Japanese encephalitis virus isolate from southern China. (19543849)
2009
47
Molecular epidemiology of Japanese encephalitis in East Asia. (19799848)
2009
48
Japanese encephalitis in mainland china. (19762980)
2009
49
Epidemiology of Japanese encephalitis in context with Indian scenario. (19552100)
2008
50
Primary viraemia responses of herons to experimental infection with Murray Valley encephalitis, Kunjin and Japanese encephalitis viruses. (6326724)
1983

Genetic Variations for Japanese Encephalitis

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Expression for genes affiliated with Japanese Encephalitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Japanese Encephalitis

Search GEO for disease gene expression data for Japanese Encephalitis.

Pathways for genes affiliated with Japanese Encephalitis

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29KEGG, 53Reactome
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Pathways related to Japanese Encephalitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.1RSAD2, CXCL10, TYK2, IVNS1ABP, DDX58, FADD
2
Hide members
10.1IFIT2, FADD, DDX58, DDX58, TYK2, TXN

Compounds for genes affiliated with Japanese Encephalitis

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44Novoseek, 11DrugBank, 24HMDB
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Compounds related to Japanese Encephalitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1cycloheximide4410.4TAT, CXCL10
2poly(i-c)4410.4RSAD2, CXCL10, DDX58
3adenine44 11 2412.3TAT, CXCL10, HELLS
4retinoic acid44 2411.0TXN, HELLS, DDX58, TYK2, CXCL10, TAT
5iodoacetate4410.0PTS, TXN
6serine449.9TXN, RP9, HELLS, FADD, TYK2, TAT

GO Terms for genes affiliated with Japanese Encephalitis

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16Gene Ontology
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Biological processes related to Japanese Encephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1modulation by virus of host morphology or physiologyGO:01904810.2RSAD2, IVNS1ABP, DDX58, FADD
2response to virusGO:00961510.1RSAD2, IVNS1ABP, DDX58, IFIT2
3defense response to virusGO:0516079.9IFIT2, FADD, CXCL10, RSAD2

Molecular functions related to Japanese Encephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055159.5NHP2L1, RP9, IFIT2, HELLS, FADD, DDX42

Products for genes affiliated with Japanese Encephalitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Japanese Encephalitis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet