JE
MCID: JPN002
MIFTS: 55

Japanese Encephalitis (JE) malady

Rare diseases, Infectious diseases, Neuronal diseases categories

Summaries for Japanese Encephalitis

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9Disease Ontology, 4CDC, 66Wikipedia, 34MalaCards
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CDC:4 Japanese encephalitis (JE) virus is the leading cause of vaccine-preventable encephalitis in Asia and the western Pacific. For most travelers to Asia, the risk for JE is very low but varies based on destination, duration of travel, season, and activities. JE virus is maintained in a cycle involving mosquitoes and vertebrate hosts, mainly pigs and wading birds. Humans can be infected when bitten by an infected mosquito. Most human infections are asymptomatic or result in only mild symptoms. However, a small percentage of infected persons develop inflammation of the brain (encephalitis), with symptoms including sudden onset of headache, high fever, disorientation, coma, tremors and convulsions. About 1 in 4 cases are fatal. There is no specific treatment for JE. Patient management focuses on supportive care and management of complications. Steps to prevent JE include using personal protective measures to prevent mosquito bites and vaccination.

MalaCards: Japanese Encephalitis, also known as japanese b encephalitis, is related to encephalitis and west nile virus, and has symptoms including stupor, convulsions and high fever. An important gene associated with Japanese Encephalitis is TMEM173 (transmembrane protein 173), and among its related pathways are Cytosolic sensors of pathogen-associated DNA and Type II interferon signaling (IFNG). The compounds 2,5-oligoadenylate and camptothecin have been mentioned in the context of this disorder. Affiliated tissues include brain, brain and b cells, and related mouse phenotypes are homeostasis/metabolism and mortality/aging.

Disease Ontology:9 A viral infectious disease that results in infection located in brain, has material basis in japanese encephalitis virus, which is transmitted by culex tritaeniorhynchus mosquito bite. the infection has symptom headache, has symptom high fever, has symptom neck stiffness, has symptom stupor, has symptom disorientation, has symptom coma, has symptom tremors, has symptom convulsions, and has symptom spastic paralysis.

Wikipedia:66 Japanese encephalitis (Japanese: ????, Nihon-n?en)?previously known as Japanese B encephalitis to... more...

Aliases & Classifications for Japanese Encephalitis

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9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 46Novoseek, 50Orphanet, 63UMLS, 59SNOMED-CT, 36MeSH, 41NCIt, 28ICD9CM, 37MESH via Orphanet, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

50
japanese encephalitis:
Inheritance: Sporadic; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

japanese encephalitis 9 44 11 50 63
japanese b encephalitis 9
encephalitis japanese 46
je 44


External Ids:

Disease Ontology9 DOID:10844
MeSH36 D004672
NCIt41 C34577
ICD9CM28 062.0
MESH via Orphanet37 D004672
ICD10 via Orphanet27 A83.0
SNOMED-CT via Orphanet60 52947006
UMLS via Orphanet64 C0014057
ICD1026 A83.0

Related Diseases for Japanese Encephalitis

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Japanese Encephalitis:



Diseases related to japanese encephalitis

Symptoms for Japanese Encephalitis

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9Disease Ontology
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Symptoms:

9 (show all 9)
  • stupor
  • convulsions
  • high fever
  • disorientation
  • coma
  • neck stiffness
  • spastic paralysis
  • tremors
  • headache

Drugs & Therapeutics for Japanese Encephalitis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Japanese Encephalitis

Drug clinical trials:

Search ClinicalTrials for Japanese Encephalitis

Search NIH Clinical Center for Japanese Encephalitis

Search CenterWatch for Japanese Encephalitis

Genetic Tests for Japanese Encephalitis

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Anatomical Context for Japanese Encephalitis

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34MalaCards, 15FMA
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MalaCards organs/tissues related to Japanese Encephalitis:

34
Brain, B cells, T cells, Testes, Kidney, Endothelial, Monocytes, Bone, Myeloid, Spleen

FMA organs/tissues related to Japanese Encephalitis:

15
Brain

Animal Models for Japanese Encephalitis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Japanese Encephalitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.7CAPRIN1, CXCL10, FADD, TMEM173, PTS
2MP:00107686.9CAPRIN1, PPIB, PTS, TMEM173, FADD, CXCL10

Publications for Japanese Encephalitis

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53PubMed
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Articles related to Japanese Encephalitis:

(show top 50)    (show all 532)
idTitleAuthorsYear
1
Detection and Differentiation of Genotype I and III Japanese Encephalitis Virus in Mosquitoes by Multiplex Reverse Transcriptase-Polymerase Chain Reaction. (23157736)
2014
2
A cohort event monitoring to determine the adverse events following administration of mouse brain derived, inactivated Japanese Encephalitis vaccine in an endemic district in Sri Lanka. (24406391)
2014
3
Cellular DDX3 regulates Japanese encephalitis virus replication by interacting with viral un-translated regions. (24418539)
2014
4
High incidence of Japanese encephalitis, southern China. (23750863)
2013
5
Recovery of a chemically synthesized Japanese encephalitis virus revealed two critical adaptive mutations in NS2B and NS4A. (24362961)
2013
6
Outcome of children with Japanese encephalitis and predictors of outcome in southwestern China. (23900120)
2013
7
Japanese encephalitis virus isolation from mosquitoes during an outbreak in 2011 in Alappuzha district, Kerala. (24220084)
2013
8
Comparative spatial dynamics of Japanese encephalitis and acute encephalitis syndrome in Nepal. (23894277)
2013
9
Molecular characterization of Japanese encephalitis viruses circulating in pigs and mosquitoes on pig farms in the Chinese province of Henan. (22945473)
2013
10
Japanese encephalitis virus activates autophagy as a viral immune evasion strategy. (23320079)
2013
11
Japanese encephalitis virus infects neuronal cells through a clathrin-independent endocytic mechanism. (23055570)
2013
12
Blocking double-stranded RNA-activated protein kinase PKR by Japanese encephalitis virus nonstructural protein 2A. (22787234)
2012
13
Pathogenic and vaccine strains of Japanese encephalitis virus elicit different levels of human macrophage effector functions. (22729616)
2012
14
Retrospective screening of serum and cerebrospinal fluid samples from patients with acute meningo-encephalitis does not reveal past Japanese encephalitis virus infection, Emilia Romagna, Italy, 2011. (22958609)
2012
15
Modelling the long-term persistence of neutralizing antibody in adults after one dose of live attenuated Japanese encephalitis chimeric virus vaccine. (22342547)
2012
16
Combination of N-methylisatin-I^-thiosemicarbazone derivative (SCH16) with ribavirin and mycophenolic acid potentiates the antiviral activity of SCH16 against Japanese encephalitis virus in vitro. (22738253)
2012
17
TNF-I+ promoter polymorphism: a factor contributing to the different immunological and clinical phenotypes in Japanese encephalitis. (22276993)
2012
18
An economic evaluation of the use of Japanese encephalitis vaccine in the expanded program of immunization of Guizhou province, China. (22698453)
2012
19
Safety and immunogenicity of a freeze-dried, cell culture-derived Japanese encephalitis vaccine (Inactivated) (JEBIK(Ar)V) in children. (22841478)
2012
20
Feasibility of cross-protective vaccination against flaviviruses of the Japanese encephalitis serocomplex. (22309667)
2012
21
Epidemiological characteristics of Japanese encephalitis in Guizhou Province, China, 1971-2009. (22840580)
2012
22
Monoclonal antibodies against NS3 and NS5 proteins of Japanese encephalitis virus. (22509919)
2012
23
DnaJ homolog Hdj2 facilitates Japanese encephalitis virus replication. (21999493)
2011
24
Broad-spectrum antiviral activity of RNA interference against four genotypes of Japanese encephalitis virus based on single microRNA polycistrons. (22028851)
2011
25
Knowledge, attitudes and practices of caregivers regarding Japanese encephalitis in Shaanxi Province, China. (21288546)
2011
26
A novel mutation (S227T) in domain II of the envelope gene of Japanese encephalitis virus circulating in North India. (20727244)
2011
27
Infection of mouse bone marrow-derived dendritic cells by live attenuated Japanese encephalitis virus induces cells maturation and triggers T cells activation. (21093495)
2011
28
Serosurveillance for Japanese encephalitis and West Nile viruses in resident birds in Hawai'i. (20688669)
2010
29
Glial activation involvement in neuronal death by Japanese encephalitis virus infection. (20007359)
2010
30
Identification of a heparin binding peptide from the Japanese encephalitis virus envelope protein. (20069543)
2010
31
Molecular evolution of Japanese encephalitis virus isolates from swine in Oita, Japan during 1980-2009. (20035900)
2010
32
New vaccines for Japanese encephalitis. (21308526)
2010
33
Japanese encephalitis virus induces matrix metalloproteinase-9 in rat brain astrocytes via NF-I_B signalling dependent on MAPKs and reactive oxygen species. (20698853)
2010
34
Adverse event reports following Japanese encephalitis vaccination in the United States, 1999-2009. (20970488)
2010
35
Japanese encephalitis virus remains an important cause of encephalitis in Thailand. (20674433)
2010
36
A new inactivated Japanese encephalitis vaccine for adult travelers. (19747666)
2009
37
Japanese encephalitis virus induce immuno-competency in neural stem/progenitor cells. (19956550)
2009
38
Virus-specific cytolytic antibodies to nonstructural protein 1 of Japanese encephalitis virus effect reduction of virus output from infected cells. (19264772)
2009
39
Expert opinion on vaccination of travelers against Japanese encephalitis. (19930391)
2009
40
Ixiaro: a new vaccine against Japanese encephalitis. (19863241)
2009
41
Japanese encephalitis in travelers: review of cases and seasonal risk. (19538584)
2009
42
Hemiplegia with dysarthria: an initial manifestation of Japanese encephalitis in a 4-year old child. (19248662)
2008
43
Identification of Japanese encephalitis virus-inducible genes in mouse brain and characterization of GARG39/IFIT2 as a microtubule-associated protein. (17030862)
2006
44
Japanese encephalitis virus NS2B-NS3 protease binding to phage-displayed human brain proteins with the domain of trypsin inhibitor and basic region leucine zipper. (16289409)
2006
45
Experimental infection of Culex annulirostris, Culex gelidus, and Aedes vigilax with a yellow fever/Japanese encephalitis virus vaccine chimera (ChimeriVax-JE). (17038690)
2006
46
Association of Japanese encephalitis virus NS3 protein with microtubules and tumour susceptibility gene 101 (TSG101) protein. (13679614)
2003
47
Ring-expanded ("fat") nucleoside and nucleotide analogues exhibit potent in vitro activity against flaviviridae NTPases/helicases, including those of the West Nile virus, hepatitis C virus, and Japanese encephalitis virus. (12954067)
2003
48
Inhibition of Japanese encephalitis virus infection by diethyldithiocarbamate is independent of its antioxidant potential. (12856920)
2003
49
Effect of cytokines on Japanese encephalitis virus production by human monocytes. (2118221)
1990
50
Antibody-capture ELISA for detection of immunoglobulin M antibodies in sera from Japanese encephalitis and dengue hemorrhagic fever patients. (2989309)
1985

Variations for Japanese Encephalitis

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Expression for genes affiliated with Japanese Encephalitis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Japanese Encephalitis

Search GEO for disease gene expression data for Japanese Encephalitis.

Pathways for genes affiliated with Japanese Encephalitis

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51PathCards, 56Reactome, 31KEGG, 39NCBI BioSystems Database
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Compounds for genes affiliated with Japanese Encephalitis

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46Novoseek, 62Tocris Bioscience, 12DrugBank, 25HMDB, 30IUPHAR
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Compounds related to Japanese Encephalitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
12,5-oligoadenylate469.4ISG15, CXCL10
2camptothecin46 62 1211.3FADD, ISG15
3neopterin469.1PTS, CXCL10
4heparan sulfate46 2510.1PPIB, CXCL10
5suramin46 30 1210.9PTS, CXCL10
6cycloheximide468.9CXCL10, FADD, ISG15
7cholesterol46 30 25 1211.6PTS, FADD, CXCL10

GO Terms for genes affiliated with Japanese Encephalitis

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17Gene Ontology
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Biological processes related to Japanese Encephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1innate immune responseGO:0450878.9ISG15, TMEM173, FADD
2positive regulation of transcription from RNA polymerase II promoterGO:0459448.8CXCL10, FADD, TMEM173
3defense response to virusGO:0516078.3CXCL10, FADD, TMEM173, ISG15

Molecular functions related to Japanese Encephalitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:0428029.0FADD, TMEM173, PTS

Products for genes affiliated with Japanese Encephalitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Japanese Encephalitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet