MCID: JPN001
MIFTS: 30

Japanese Spotted Fever malady

Category: Infectious diseases

Aliases & Classifications for Japanese Spotted Fever

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Aliases & Descriptions for Japanese Spotted Fever:

Name: Japanese Spotted Fever 11 13
Rickettsia Japonica Spotted Fever 11
 
Oriental Spotted Fever 11

Classifications:



External Ids:

Disease Ontology11 DOID:0050050

Summaries for Japanese Spotted Fever

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Disease Ontology:11 A spotted fever that has material basis in Rickettsia japonica, which is transmitted by ticks (Dermacentor taiwanensis and Haemaphysalis flava). The infection has symptom fever, has symptom eschars, has symptom regional adenopathy, and has symptom rash on extremities.

MalaCards based summary: Japanese Spotted Fever, also known as rickettsia japonica spotted fever, is related to spotted fever and exanthem, and has symptoms including fever, eschars and regional adenopathy. An important gene associated with Japanese Spotted Fever is AFF2 (AF4/FMR2 Family Member 2), and among its related pathways are CXCR3-mediated signaling events and NF-kappa B signaling pathway. Affiliated tissues include testes and skin.

Wikipedia:71 Japanese spotted fever (or oriental spotted fever) is a condition characterized by a rash that has early... more...

Related Diseases for Japanese Spotted Fever

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Diseases related to Japanese Spotted Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 84)
idRelated DiseaseScoreTop Affiliating Genes
1spotted fever30.9CD40LG, KANTR
2exanthem10.3AFF2, PLEKHG4
3rabies10.3AFF2, CD40LG
4flinders island spotted fever10.3CD40LG, PLEKHG4
5hemorrhagic fever with renal syndrome10.3AFF2, CD40LG
6pestis minor10.3AFF2, CD40LG
7polycythemia due to hypoxia10.2CD40LG, CRP
8cannabis dependence10.2CD40LG, CRP
9leiomyosarcoma10.2CD40LG, CRP
10chronic mucocutaneous candidiasis10.2CD40LG, CRP
11spinal canal and spinal cord meningioma10.2CD40LG, KANTR
12ovarian serous cystadenocarcinoma10.2CD40LG, CRP
13amyotrohpic lateral sclerosis type 2210.2CD40LG, CXCL10
14chronic fungal otitis externa10.2CD40LG, CRP
15facial nerve neoplasm10.2CD40LG, KANTR
16hypertensive heart disease10.2CD40LG, CRP
17human immunodeficiency virus infectious disease10.2CD40LG, CRP
18spastic ataxia 7, autosomal dominant10.2CD40LG, KANTR
19homocystinuria10.2CD40LG, KANTR
20natural killer cell leukemia10.2CCL11, CRP
21rocky mountain spotted fever10.2AFF2, CD40LG, PLEKHG4
22dyskeratosis congenita10.2CD40LG, CXCL10
23anal canal adenocarcinoma10.2CD40LG, KANTR
24cyclotropia10.2CD40LG, CRP
25pseudohypoaldosteronism, type iic10.2CD40LG, CXCL10
26retinal degeneration10.2CD40LG, CRP
27cysticercosis10.2CD40LG, SERPINC1
28freiberg's disease10.2CD40LG, SERPINC1
29hereditary endotheliopathy, retinopathy, nephropathy, and stroke10.2CD40LG, SERPINC1
30benign paroxysmal positional nystagmus10.2CD40LG, KANTR
31dysplastic nevus syndrome10.2CD40LG, CXCL10
32cardiovascular cancer10.2CD40LG, KANTR
33megaloblastic anemia10.2CD40LG, CRP
34dermatomycosis10.1CD40LG, CRP
35temtamy syndrome10.1CD40LG, CXCL10
36omphalocele10.1CRP, KANTR
37bazex syndrome10.1CRP, KANTR
38glycogen storage disease viii10.1CD40LG, CRP
39cataract10.1CRP, SERPINC1
40czech dysplasia10.1CD40LG, SERPINC1
41hidrocystoma10.1CD40LG, KANTR
42midline cystocele10.1CRP, SERPINC1
43primrose syndrome10.1CRP, KANTR
44chorioretinal scar10.1KANTR, SERPINC1
45constant exophthalmos10.1CCL4, CCL4L1
46secretory diarrhea myopathy and deafness10.1CRP, SERPINC1
47epstein-barr virus hepatitis10.1CD40LG, SERPINC1
48sennetsu fever10.1AFF2, CD40LG
49acute chest syndrome10.1CCL11, CD40LG, CRP
50intravascular angioleiomyoma10.1CCL11, CD40LG

Graphical network of the top 20 diseases related to Japanese Spotted Fever:



Diseases related to japanese spotted fever

Symptoms & Phenotypes for Japanese Spotted Fever

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Symptoms:

 11 (show all 4)
  • fever
  • eschars
  • regional adenopathy
  • rash on extremities

Drugs & Therapeutics for Japanese Spotted Fever

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Japanese Spotted Fever

Genetic Tests for Japanese Spotted Fever

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Anatomical Context for Japanese Spotted Fever

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MalaCards organs/tissues related to Japanese Spotted Fever:

36
Testes, Skin

Publications for Japanese Spotted Fever

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Articles related to Japanese Spotted Fever:

(show all 31)
idTitleAuthorsYear
1
Improvement in early diagnosis of Japanese spotted fever by using a novel Rick PCR system. (26130479)
2015
2
Significantly higher cytokine and chemokine levels in patients with Japanese spotted fever than in those with Tsutsugamushi disease. (24671792)
2014
3
A neonatal case of Japanese spotted fever. (23743544)
2013
4
A case of Japanese spotted fever complicated with central nervous system involvement and multiple organ failure. (22466839)
2012
5
Histopathological diagnosis of Japanese spotted fever using formalin-fixed, paraffin-embedded skin biopsy specimens: usefulness of immunohistochemistry and real-time PCR analysis. (21668575)
2012
6
Serological survey of five zoonoses, scrub typhus, Japanese spotted fever, tularemia, Lyme disease, and Q fever, in feral raccoons (Procyon lotor) in Japan. (20553108)
2011
7
Predictive values of clinical parameters for severe Japanese spotted fever. (20827564)
2011
8
Japanese spotted fever with acute hepatic failure: was it associated with Epstein-Barr virus? (21091673)
2010
9
Surveillance, recognition, and reporting of Tsutsugamushi disease (scrub typhus) and Japanese spotted fever by general practice clinics in Miyazaki Prefecture, determined by questionnaire survey in 2007. (19688250)
2009
10
The first fatal case of Japanese spotted fever confirmed by serological and microbiological tests in Awaji Island, Japan. (17642547)
2007
11
A case of Japanese spotted fever complicated with acute myocarditis. (17314430)
2007
12
Severe Japanese spotted fever successfully treated with fluoroquinolone. (17170509)
2006
13
Simultaneous development of Japanese spotted fever in a married couple in Kagoshima Prefecture. (16922489)
2006
14
Japanese spotted fever, South Korea. (16836831)
2006
15
Epidemiology of tsutsugamushi disease and Japanese spotted fever in Kagoshima Prefecture, Japan. (16936351)
2006
16
Epidemiological study of Japanese spotted fever and tsutsugamushi disease in Shimane Prefecture, Japan. (16785708)
2006
17
Japanese spotted fever in Korea. (16082011)
2005
18
Clinical study of Japanese spotted fever and its aggravating factors. (12673413)
2003
19
Japanese spotted fever involving the central nervous system: two case reports and a literature review. (12354906)
2002
20
Fulminant Japanese spotted fever definitively diagnosed by the polymerase chain reaction method. (12373493)
2002
21
Fulminant Japanese spotted fever associated with hypercytokinemia. (11376087)
2001
22
Japanese spotted fever associated with multiorgan failure. (11810592)
2001
23
A patient with Japanese spotted fever complicated by meningoencephalitis. (11605191)
2001
24
The first reported case of Japanese spotted fever in Hiroshima Prefecture, Japan. (11135712)
2000
25
Japanese spotted fever in Shimane Prefecture - outbreak and place of infection. (10871919)
2000
26
Outbreak of Japanese spotted fever in the southeastern part of Awaji Island. (10783585)
2000
27
Japanese spotted fever cases in Kochi prefecture. (10777859)
2000
28
Japanese spotted fever: report of 31 cases and review of the literature. (9204291)
1997
29
First isolation of a rickettsia closely related to Japanese spotted fever pathogen from a tick in Japan. (8189407)
1994
30
Serological studies of antigenic similarity between Japanese spotted fever rickettsiae and Weil-Felix test antigens. (1383270)
1992
31
Gelatin particle agglutination test for early serodiagnosis of Japanese spotted fever. (1603001)
1992

Variations for Japanese Spotted Fever

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Expression for genes affiliated with Japanese Spotted Fever

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Search GEO for disease gene expression data for Japanese Spotted Fever.

Pathways for genes affiliated with Japanese Spotted Fever

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GO Terms for genes affiliated with Japanese Spotted Fever

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Cellular components related to Japanese Spotted Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056156.9CCL11, CCL4, CCL4L1, CD40LG, CRP, CXCL10

Biological processes related to Japanese Spotted Fever according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1lymphocyte chemotaxisGO:004824710.3CCL11, CCL4L1
2cellular response to interferon-gammaGO:00713469.6CCL11, CCL4, CCL4L1
3cellular response to interleukin-1GO:00713479.6CCL11, CCL4, CCL4L1
4cellular response to tumor necrosis factorGO:00713569.6CCL11, CCL4, CCL4L1
5monocyte chemotaxisGO:00025489.5CCL11, CCL4, CCL4L1
6neutrophil chemotaxisGO:00305939.5CCL11, CCL4, CCL4L1
7chemotaxisGO:00069359.4CCL11, CCL4, CXCL10
8positive regulation of ERK1 and ERK2 cascadeGO:00703749.4CCL11, CCL4, CCL4L1
9chemokine-mediated signaling pathwayGO:00700989.1CCL11, CCL4, CCL4L1, CXCL10
10immune responseGO:00069559.1CCL11, CCL4, CD40LG, CXCL10
11response to virusGO:00096158.7CCL11, CCL4, CXCL10
12inflammatory responseGO:00069548.2CCL11, CCL4, CCL4L1, CD40LG, CRP, CXCL10

Molecular functions related to Japanese Spotted Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1CCR chemokine receptor bindingGO:004802010.3CCL11, CCL4L1
2chemokine activityGO:00080098.9CCL11, CCL4, CCL4L1, CXCL10
3cytokine activityGO:00051258.4CCL11, CCL4, CD40LG, CXCL10

Sources for Japanese Spotted Fever

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet