MCID: JPN001
MIFTS: 30

Japanese Spotted Fever malady

Category: Infectious diseases

Aliases & Classifications for Japanese Spotted Fever

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Aliases & Descriptions for Japanese Spotted Fever:

Name: Japanese Spotted Fever 11 13
Rickettsia Japonica Spotted Fever 11
 
Oriental Spotted Fever 11

Classifications:



External Ids:

Disease Ontology11 DOID:0050050

Summaries for Japanese Spotted Fever

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Disease Ontology:11 A spotted fever that has material basis in Rickettsia japonica, which is transmitted by ticks (Dermacentor taiwanensis and Haemaphysalis flava). The infection has symptom fever, has symptom eschars, has symptom regional adenopathy, and has symptom rash on extremities.

MalaCards based summary: Japanese Spotted Fever, also known as rickettsia japonica spotted fever, is related to social phobia and trachoma, and has symptoms including fever, eschars and regional adenopathy. An important gene associated with Japanese Spotted Fever is AFF2 (AF4/FMR2 Family Member 2), and among its related pathways are CXCR3-mediated signaling events and NF-kappa B signaling pathway. Affiliated tissues include testes and skin.

Wikipedia:71 Japanese spotted fever (or oriental spotted fever) is a condition characterized by a rash that has early... more...

Related Diseases for Japanese Spotted Fever

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Diseases related to Japanese Spotted Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 105)
idRelated DiseaseScoreTop Affiliating Genes
1social phobia10.6AFF2, CD40LG
2trachoma10.6AFF2, CD40LG
3far eastern spotted fever10.6CD40LG, PLEKHG4
4erysipeloid10.6AFF2, CD40LG
5aneruptive fever10.5AFF2, CD40LG
6bone cancer10.4CD40LG, CRP
7dehydration polycythemia10.4CD40LG, CRP
8calcinosis10.4CD40LG, CRP
9fallopian tube leiomyosarcoma10.4CD40LG, CRP
10small intestinal vasoactive intestinal peptide producing tumor10.4CD40LG, CRP
11beach ear10.4CD40LG, CRP
12post-traumatic stress disorder10.4CD40LG, CRP
13acquired thrombocytopenia10.4CD40LG, CRP
14conventional leiomyosarcoma10.4CD40LG, CRP
15cyclothymic disorder10.4CD40LG, CRP
16polyarteritis nodosa10.4CD40LG, CRP
17gait apraxia10.4CCL11, CD40LG
18chromoblastomycosis10.4CD40LG, CRP
19heart disease10.4CD40LG, KANTR
20spotted fever10.4
21rickettsialpox10.4CD40LG, KANTR
22pompholyx10.4CD40LG, KANTR
23solitary cyst of breast10.4CCL11, CRP
24pyrimidine metabolic disorder10.4CD40LG, CRP
25facial nerve neoplasm10.4CD40LG, KANTR
26gastric hemangioma10.4CD40LG, CRP
27brachial plexus neuropathy10.4CD40LG, KANTR
28artery disease10.4CD40LG, CRP
29capillary hemangioma10.4CD40LG, CXCL10
30juvenile dermatitis herpetiformis10.4CCL11, CD40LG
31rickettsia parkeri spotted fever10.4AFF2, CD40LG, PLEKHG4
32sennetsu fever10.4AFF2, CD40LG, PLEKHG4
33urinary schistosomiasis10.3CD40LG, KANTR
34american histoplasmosis10.3CD40LG, KANTR
35balantidiasis10.3CD40LG, CRP
36spondylosis10.3CD40LG, CRP
37lynch syndrome10.3CD40LG, KANTR
38early congenital syphilis10.3CD40LG, CRP
39diphyllobothriasis10.3CD40LG, SERPINC1
40marek disease10.3CD40LG, SERPINC1
41hepatic fibrosis renal cysts mental retardation10.3CD40LG, SERPINC1
42compensatory emphysema10.3CD40LG, CRP
43borst-jadassohn intraepidermal carcinoma10.3CCL11, CD40LG
44myelomeningocele10.3CRP, KANTR
45steroid-induced glaucoma10.3CD40LG, CRP
46intestinal pseudo-obstruction10.3CD40LG, KANTR
47dentin dysplasia10.3CD40LG, CXCL10
48prostatic hypertrophy10.3CD40LG, SERPINC1
49oesophagostomiasis10.3CD40LG, KANTR
50stickler sydrome, type i, nonsyndromic ocular10.3CD40LG, SERPINC1

Graphical network of the top 20 diseases related to Japanese Spotted Fever:



Diseases related to japanese spotted fever

Symptoms & Phenotypes for Japanese Spotted Fever

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Symptoms:

 11 (show all 4)
  • fever
  • eschars
  • regional adenopathy
  • rash on extremities

Drugs & Therapeutics for Japanese Spotted Fever

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Japanese Spotted Fever

Genetic Tests for Japanese Spotted Fever

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Anatomical Context for Japanese Spotted Fever

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MalaCards organs/tissues related to Japanese Spotted Fever:

36
Testes, Skin

Publications for Japanese Spotted Fever

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Articles related to Japanese Spotted Fever:

(show all 31)
idTitleAuthorsYear
1
Improvement in early diagnosis of Japanese spotted fever by using a novel Rick PCR system. (26130479)
2015
2
Significantly higher cytokine and chemokine levels in patients with Japanese spotted fever than in those with Tsutsugamushi disease. (24671792)
2014
3
A neonatal case of Japanese spotted fever. (23743544)
2013
4
Histopathological diagnosis of Japanese spotted fever using formalin-fixed, paraffin-embedded skin biopsy specimens: usefulness of immunohistochemistry and real-time PCR analysis. (21668575)
2012
5
A case of Japanese spotted fever complicated with central nervous system involvement and multiple organ failure. (22466839)
2012
6
Predictive values of clinical parameters for severe Japanese spotted fever. (20827564)
2011
7
Serological survey of five zoonoses, scrub typhus, Japanese spotted fever, tularemia, Lyme disease, and Q fever, in feral raccoons (Procyon lotor) in Japan. (20553108)
2011
8
Japanese spotted fever with acute hepatic failure: was it associated with Epstein-Barr virus? (21091673)
2010
9
Surveillance, recognition, and reporting of Tsutsugamushi disease (scrub typhus) and Japanese spotted fever by general practice clinics in Miyazaki Prefecture, determined by questionnaire survey in 2007. (19688250)
2009
10
A case of Japanese spotted fever complicated with acute myocarditis. (17314430)
2007
11
The first fatal case of Japanese spotted fever confirmed by serological and microbiological tests in Awaji Island, Japan. (17642547)
2007
12
Simultaneous development of Japanese spotted fever in a married couple in Kagoshima Prefecture. (16922489)
2006
13
Epidemiology of tsutsugamushi disease and Japanese spotted fever in Kagoshima Prefecture, Japan. (16936351)
2006
14
Epidemiological study of Japanese spotted fever and tsutsugamushi disease in Shimane Prefecture, Japan. (16785708)
2006
15
Japanese spotted fever, South Korea. (16836831)
2006
16
Severe Japanese spotted fever successfully treated with fluoroquinolone. (17170509)
2006
17
Japanese spotted fever in Korea. (16082011)
2005
18
Clinical study of Japanese spotted fever and its aggravating factors. (12673413)
2003
19
Fulminant Japanese spotted fever definitively diagnosed by the polymerase chain reaction method. (12373493)
2002
20
Japanese spotted fever involving the central nervous system: two case reports and a literature review. (12354906)
2002
21
A patient with Japanese spotted fever complicated by meningoencephalitis. (11605191)
2001
22
Fulminant Japanese spotted fever associated with hypercytokinemia. (11376087)
2001
23
Japanese spotted fever associated with multiorgan failure. (11810592)
2001
24
Outbreak of Japanese spotted fever in the southeastern part of Awaji Island. (10783585)
2000
25
Japanese spotted fever cases in Kochi prefecture. (10777859)
2000
26
Japanese spotted fever in Shimane Prefecture - outbreak and place of infection. (10871919)
2000
27
The first reported case of Japanese spotted fever in Hiroshima Prefecture, Japan. (11135712)
2000
28
Japanese spotted fever: report of 31 cases and review of the literature. (9204291)
1997
29
First isolation of a rickettsia closely related to Japanese spotted fever pathogen from a tick in Japan. (8189407)
1994
30
Serological studies of antigenic similarity between Japanese spotted fever rickettsiae and Weil-Felix test antigens. (1383270)
1992
31
Gelatin particle agglutination test for early serodiagnosis of Japanese spotted fever. (1603001)
1992

Variations for Japanese Spotted Fever

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Expression for genes affiliated with Japanese Spotted Fever

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Search GEO for disease gene expression data for Japanese Spotted Fever.

Pathways for genes affiliated with Japanese Spotted Fever

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GO Terms for genes affiliated with Japanese Spotted Fever

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Cellular components related to Japanese Spotted Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056156.9CCL11, CCL4, CCL4L1, CD40LG, CRP, CXCL10

Biological processes related to Japanese Spotted Fever according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1lymphocyte chemotaxisGO:004824710.3CCL11, CCL4L1
2cellular response to interferon-gammaGO:00713469.6CCL11, CCL4, CCL4L1
3cellular response to interleukin-1GO:00713479.6CCL11, CCL4, CCL4L1
4cellular response to tumor necrosis factorGO:00713569.6CCL11, CCL4, CCL4L1
5monocyte chemotaxisGO:00025489.5CCL11, CCL4, CCL4L1
6neutrophil chemotaxisGO:00305939.5CCL11, CCL4, CCL4L1
7positive regulation of ERK1 and ERK2 cascadeGO:00703749.5CCL11, CCL4, CCL4L1
8positive regulation of inflammatory responseGO:00507299.4CCL11, CCL4, CCL4L1
9chemokine-mediated signaling pathwayGO:00700989.0CCL11, CCL4, CCL4L1, CXCL10
10response to virusGO:00096158.7CCL11, CCL4, CXCL10
11inflammatory responseGO:00069548.2CCL11, CCL4, CCL4L1, CD40LG, CRP, CXCL10

Molecular functions related to Japanese Spotted Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1CCR chemokine receptor bindingGO:004802010.1CCL11, CCL4L1
2chemokine activityGO:00080098.3CCL11, CCL4, CCL4L1, CXCL10

Sources for Japanese Spotted Fever

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet