MCID: JPN001
MIFTS: 33

Japanese Spotted Fever malady

Infectious diseases category

Aliases & Classifications for Japanese Spotted Fever

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Aliases & Descriptions for Japanese Spotted Fever:

Name: Japanese Spotted Fever 10 12
Rickettsia Japonica Spotted Fever 10
 
Oriental Spotted Fever 10


Classifications:



External Ids:

Disease Ontology10 DOID:0050050

Summaries for Japanese Spotted Fever

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Disease Ontology:10 A spotted fever that has material basis in rickettsia japonica, which is transmitted by ticks (dermacentor taiwanensis and haemaphysalis flava). the infection has symptom fever, has symptom eschars, has symptom regional adenopathy, and has symptom rash on extremities.

MalaCards based summary: Japanese Spotted Fever, also known as rickettsia japonica spotted fever, is related to acute myocarditis and spotted fever, and has symptoms including fever, eschars and regional adenopathy. An important gene associated with Japanese Spotted Fever is YAP1 (Yes-Associated Protein 1), and among its related pathways are CXCR3-mediated signaling events and A-beta Uptake and Degradation. Affiliated tissues include testes and skin, and related mouse phenotype immune system.

Wikipedia:68 Japanese spotted fever (or oriental spotted fever) is a condition characterized by a rash that has early... more...

Related Diseases for Japanese Spotted Fever

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Diseases related to Japanese Spotted Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 123)
idRelated DiseaseScoreTop Affiliating Genes
1acute myocarditis30.7CD40LG, CRP
2spotted fever10.9
3scrub typhus10.3
4typhus10.3
5recurrent corneal erosion10.3CD40LG, CRP
6mononeuritis of lower limb10.3CD40LG, CRP
7post-traumatic stress disorder10.3CD40LG, CRP
8fallopian tube germ cell cancer10.3CD40LG, CRP
9salpingo-oophoritis10.3CD40LG, CRP
10penis sarcoma10.3CD40LG, CRP
11supraglottis cancer10.3CD40LG, CRP
12chronic myeloproliferative disease10.3CCL11, CRP
13keratoderma hereditarium mutilans with ichthyosis10.3CD40LG, CRP
14cerebellar astrocytoma10.3CD40LG, CRP
15intestinal impaction10.3CD40LG, CRP
16acromesomelic dysplasia10.3CD40LG, CXCL10
17hyperthyroidism10.3CD40LG, CRP
18latent syphilis10.3CD40LG, GOT1
19larynx squamous papilloma10.2CD40LG, SERPINC1
20fowler's syndrome10.2CD40LG, SERPINC1
21hepatic cystic hamartoma10.2CD40LG, SERPINC1
22pyelonephritis10.2CD40LG, CRP
23triple-receptor negative breast cancer10.2CD40LG, CRP
24cerebellar vermis medulloblastoma10.2CD40LG, CRP
25endocervical carcinoma10.2CD40LG, CRP
26conjunctivitis10.2CCL11, CD40LG
27abducens nerve neoplasm10.2CRP, SERPINC1
28lambert-eaton myasthenic syndrome10.2CD40LG, SERPINC1
29congenital chloride diarrhea10.2CRP, SERPINC1
30phalanx chondroma10.2CCL11, CCL2
31tyrosinemia10.2CD40LG, CRP
32acute pulmonary heart disease10.2CCL2, CD40LG
33choroid epithelioid cell melanoma10.2CCL11, CD40LG
34loeffler syndrome10.2CCL11, CCL2
35dysgammaglobulinemia10.2CD40LG, CRP
36hemorrhagic proctocolitis10.2CD40LG, SERPINC1
37diffuse pulmonary fibrosis10.2GOT1, GOT2
38tympanosclerosis10.2GOT1, GOT2
39mesocestoidiasis10.2GOT1, GOT2
40anaerobic pneumonia10.2GOT1, GOT2
41venezuelan hemorrhagic fever10.2GOT1, GOT2
42anti-hla hyperimmunization10.2CCL2, CXCL10
43hepatitis10.2
44q fever10.2
45meningoencephalitis10.2
46lyme disease10.2
47myocarditis10.2
48tularemia10.2
49diamond-blackfan anemia 410.2GOT1, GOT2
50peritoneal benign neoplasm10.2CRP, SERPINC1

Graphical network of the top 20 diseases related to Japanese Spotted Fever:



Diseases related to japanese spotted fever

Symptoms for Japanese Spotted Fever

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Symptoms:

 10
  • fever
  • eschars
  • regional adenopathy
  • rash on extremities

Drugs & Therapeutics for Japanese Spotted Fever

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Japanese Spotted Fever

Genetic Tests for Japanese Spotted Fever

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Anatomical Context for Japanese Spotted Fever

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MalaCards organs/tissues related to Japanese Spotted Fever:

33
Testes, Skin

Animal Models for Japanese Spotted Fever or affiliated genes

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MGI Mouse Phenotypes related to Japanese Spotted Fever:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.9CCL11, CCL2, CD40LG, CRP, CXCL10, SERPINC1

Publications for Japanese Spotted Fever

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Articles related to Japanese Spotted Fever:

(show all 31)
idTitleAuthorsYear
1
Improvement in early diagnosis of Japanese spotted fever by using a novel Rick PCR system. (26130479)
2015
2
Significantly higher cytokine and chemokine levels in patients with Japanese spotted fever than in those with Tsutsugamushi disease. (24671792)
2014
3
A neonatal case of Japanese spotted fever. (23743544)
2013
4
A case of Japanese spotted fever complicated with central nervous system involvement and multiple organ failure. (22466839)
2012
5
Histopathological diagnosis of Japanese spotted fever using formalin-fixed, paraffin-embedded skin biopsy specimens: usefulness of immunohistochemistry and real-time PCR analysis. (21668575)
2012
6
Predictive values of clinical parameters for severe Japanese spotted fever. (20827564)
2011
7
Serological survey of five zoonoses, scrub typhus, Japanese spotted fever, tularemia, Lyme disease, and Q fever, in feral raccoons (Procyon lotor) in Japan. (20553108)
2011
8
Japanese spotted fever with acute hepatic failure: was it associated with Epstein-Barr virus? (21091673)
2010
9
Surveillance, recognition, and reporting of Tsutsugamushi disease (scrub typhus) and Japanese spotted fever by general practice clinics in Miyazaki Prefecture, determined by questionnaire survey in 2007. (19688250)
2009
10
A case of Japanese spotted fever complicated with acute myocarditis. (17314430)
2007
11
The first fatal case of Japanese spotted fever confirmed by serological and microbiological tests in Awaji Island, Japan. (17642547)
2007
12
Epidemiological study of Japanese spotted fever and tsutsugamushi disease in Shimane Prefecture, Japan. (16785708)
2006
13
Japanese spotted fever, South Korea. (16836831)
2006
14
Simultaneous development of Japanese spotted fever in a married couple in Kagoshima Prefecture. (16922489)
2006
15
Epidemiology of tsutsugamushi disease and Japanese spotted fever in Kagoshima Prefecture, Japan. (16936351)
2006
16
Severe Japanese spotted fever successfully treated with fluoroquinolone. (17170509)
2006
17
Japanese spotted fever in Korea. (16082011)
2005
18
Clinical study of Japanese spotted fever and its aggravating factors. (12673413)
2003
19
Fulminant Japanese spotted fever definitively diagnosed by the polymerase chain reaction method. (12373493)
2002
20
Japanese spotted fever involving the central nervous system: two case reports and a literature review. (12354906)
2002
21
Fulminant Japanese spotted fever associated with hypercytokinemia. (11376087)
2001
22
Japanese spotted fever associated with multiorgan failure. (11810592)
2001
23
A patient with Japanese spotted fever complicated by meningoencephalitis. (11605191)
2001
24
Outbreak of Japanese spotted fever in the southeastern part of Awaji Island. (10783585)
2000
25
Japanese spotted fever cases in Kochi prefecture. (10777859)
2000
26
Japanese spotted fever in Shimane Prefecture - outbreak and place of infection. (10871919)
2000
27
The first reported case of Japanese spotted fever in Hiroshima Prefecture, Japan. (11135712)
2000
28
Japanese spotted fever: report of 31 cases and review of the literature. (9204291)
1997
29
First isolation of a rickettsia closely related to Japanese spotted fever pathogen from a tick in Japan. (8189407)
1994
30
Gelatin particle agglutination test for early serodiagnosis of Japanese spotted fever. (1603001)
1992
31
Serological studies of antigenic similarity between Japanese spotted fever rickettsiae and Weil-Felix test antigens. (1383270)
1992

Variations for Japanese Spotted Fever

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Expression for genes affiliated with Japanese Spotted Fever

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Search GEO for disease gene expression data for Japanese Spotted Fever.

Pathways for genes affiliated with Japanese Spotted Fever

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GO Terms for genes affiliated with Japanese Spotted Fever

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Cellular components related to Japanese Spotted Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055767.5CCL11, CCL2, CCL4, CRP, CXCL10, SERPINC1
2extracellular spaceGO:00056157.5CCL11, CCL2, CCL4, CD40LG, CRP, CXCL10

Biological processes related to Japanese Spotted Fever according to GeneCards Suite gene sharing:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1aspartate biosynthetic processGO:000653210.2GOT1, GOT2
2glutamate catabolic process to aspartateGO:001955010.2GOT1, GOT2
3glutamate catabolic process to 2-oxoglutarateGO:001955110.2GOT1, GOT2
4dicarboxylic acid metabolic processGO:004364810.2GOT1, GOT2
5response to gamma radiationGO:001033210.2CCL2, CXCL10
6oxaloacetate metabolic processGO:000610710.2GOT1, GOT2
7cellular amino acid biosynthetic processGO:000865210.2GOT1, GOT2
8glutamate metabolic processGO:000653610.2GOT1, GOT2
92-oxoglutarate metabolic processGO:000610310.1GOT1, GOT2
10lymphocyte chemotaxisGO:004824710.1CCL11, CCL2
11positive regulation of monocyte chemotaxisGO:009002610.0CCL2, CXCL10
12aspartate metabolic processGO:00065319.7GOT1, GOT2
13aspartate catabolic processGO:00065339.6GOT1, GOT2
14eosinophil chemotaxisGO:00482459.6CCL11, CCL2, CCL4
15monocyte chemotaxisGO:00025489.5CCL11, CCL2, CCL4
16chemotaxisGO:00069359.4CCL11, CCL2, CXCL10
17cellular response to interleukin-1GO:00713479.4CCL11, CCL2, CCL4
18cellular response to interferon-gammaGO:00713469.3CCL11, CCL2, CCL4
19cellular response to tumor necrosis factorGO:00713569.3CCL11, CCL2, CCL4
20neutrophil chemotaxisGO:00305939.3CCL11, CCL2, CCL4
21response to virusGO:00096159.2CCL11, CCL4, CXCL10
22chemokine-mediated signaling pathwayGO:00700988.9CCL11, CCL2, CCL4, CXCL10
23positive regulation of ERK1 and ERK2 cascadeGO:00703748.7CCL11, CCL2, CCL4
24immune responseGO:00069558.5CCL11, CCL2, CCL4, CD40LG, CXCL10
25inflammatory responseGO:00069548.3CCL11, CCL2, CCL4, CD40LG, CRP, CXCL10

Molecular functions related to Japanese Spotted Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1L-aspartate:2-oxoglutarate aminotransferase activityGO:000406910.0GOT1, GOT2
2carboxylic acid bindingGO:003140610.0GOT1, GOT2
3L-phenylalanine:2-oxoglutarate aminotransferase activityGO:008013010.0GOT1, GOT2
4heparin bindingGO:00082019.2CCL2, CXCL10, SERPINC1
5chemokine activityGO:00080098.6CCL11, CCL2, CCL4, CXCL10

Sources for Japanese Spotted Fever

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet