MCID: JPN001
MIFTS: 37

Japanese Spotted Fever malady

Category: Infectious diseases

Aliases & Classifications for Japanese Spotted Fever

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Aliases & Descriptions for Japanese Spotted Fever:

Name: Japanese Spotted Fever 10 12
Rickettsia Japonica Spotted Fever 10
 
Oriental Spotted Fever 10

Classifications:



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Disease Ontology10 DOID:0050050

Summaries for Japanese Spotted Fever

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Disease Ontology:10 A spotted fever that has material basis in Rickettsia japonica, which is transmitted by ticks (Dermacentor taiwanensis and Haemaphysalis flava). The infection has symptom fever, has symptom eschars, has symptom regional adenopathy, and has symptom rash on extremities.

MalaCards based summary: Japanese Spotted Fever, also known as rickettsia japonica spotted fever, is related to diabetic ketoacidosis and neuritis, and has symptoms including fever, eschars and regional adenopathy. An important gene associated with Japanese Spotted Fever is YAP1 (Yes Associated Protein 1), and among its related pathways are CXCR3-mediated signaling events and A-beta Pathways: Uptake and Degradation. Affiliated tissues include brain, colon and lung, and related mouse phenotype immune system.

Wikipedia:68 Japanese spotted fever (or oriental spotted fever) is a condition characterized by a rash that has early... more...

Related Diseases for Japanese Spotted Fever

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Diseases related to Japanese Spotted Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 114)
idRelated DiseaseScoreTop Affiliating Genes
1diabetic ketoacidosis10.6CD40LG, CRP
2neuritis10.6CD40LG, CRP
3intracranial embolism10.6CD40LG, CRP
4fallopian tube carcinoma10.6CD40LG, CRP
5maxillary sinusitis10.6CD40LG, CRP
6peripheral nervous system disease10.6CD40LG, CRP
7malignant otitis externa10.6CD40LG, CRP
8rhinoscleroma10.6CD40LG, CRP
9rumination disorder10.6CD40LG, CRP
10blepharophimosis10.6CCL11, CRP
11keratoderma hereditarium mutilans with ichthyosis10.6CD40LG, CRP
12inflammatory leiomyosarcoma10.6CD40LG, CRP
13intestinal impaction10.6CD40LG, CRP
14diffuse secondary choroid atrophy10.6CD40LG, CRP
15temporal arteritis10.6CD40LG, CRP
16focal labyrinthitis10.6CD40LG, CRP
17hemosiderosis10.6CD40LG, CRP
18splenic infarction10.6CD40LG, CRP
19narcissistic personality disorder10.5CD40LG, CRP
20melorheostosis10.5CCL11, CD40LG
21peripheral artery disease10.5CD40LG, CRP
22tricuspid valve disease10.5CD40LG, CRP
23social phobia10.5CD40LG, CRP
24vascular skin disease10.5CD40LG, GOT1
25spotted fever10.5
26hymenolepiasis10.5CD40LG, SERPINC1
27fowler's syndrome10.5CD40LG, SERPINC1
28neuroretinitis10.5CD40LG, CRP
29constant exophthalmos10.5CD40LG, CRP
30nephropathia epidemica10.4CD40LG, SERPINC1
31endocarditis10.4CRP, CXCL10
32autoimmune disease of blood10.4CD40LG, GOT1
33abducens nerve neoplasm10.4CRP, SERPINC1
34hemorrhagic proctocolitis10.4CD40LG, SERPINC1
35malignant mesenchymoma10.4CCL2, CD40LG
36aggressive digital papillary adenocarcinoma10.4CRP, CXCL10
37endemic goiter10.4CRP, CXCL10
38lacrimal system cancer10.4CD40LG, CXCL10
39urethral villous adenoma10.4GOT1, GOT2
40descending colon cancer10.4GOT1, GOT2
41peptic ulcer disease10.4CD40LG, CRP
42mesocestoidiasis10.4GOT1, GOT2
43colon carcinoma in situ10.4GOT1, GOT2
44congenital chloride diarrhea10.4CRP, SERPINC1
45venezuelan hemorrhagic fever10.4GOT1, GOT2
46postcholecystectomy syndrome10.4CCL11, CD40LG
47diamond-blackfan anemia 410.4GOT1, GOT2
48kluver-bucy syndrome10.3GOT1, GOT2
49prolapse of female genital organ10.3GOT1, GOT2
50crescentic glomerulonephritis10.3CCL2, CD40LG

Graphical network of the top 20 diseases related to Japanese Spotted Fever:



Diseases related to japanese spotted fever

Symptoms for Japanese Spotted Fever

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Symptoms:

 10
  • fever
  • eschars
  • regional adenopathy
  • rash on extremities

Drugs & Therapeutics for Japanese Spotted Fever

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Japanese Spotted Fever

Genetic Tests for Japanese Spotted Fever

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Anatomical Context for Japanese Spotted Fever

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MalaCards organs/tissues related to Japanese Spotted Fever:

33
Brain, Colon, Lung, Liver, Skin, Prostate, Pineal

Animal Models for Japanese Spotted Fever or affiliated genes

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MGI Mouse Phenotypes related to Japanese Spotted Fever:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.6CCL11, CCL2, CD40LG, CRP, CXCL10, SERPINC1

Publications for Japanese Spotted Fever

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Articles related to Japanese Spotted Fever:

(show all 31)
idTitleAuthorsYear
1
Improvement in early diagnosis of Japanese spotted fever by using a novel Rick PCR system. (26130479)
2015
2
Significantly higher cytokine and chemokine levels in patients with Japanese spotted fever than in those with Tsutsugamushi disease. (24671792)
2014
3
A neonatal case of Japanese spotted fever. (23743544)
2013
4
A case of Japanese spotted fever complicated with central nervous system involvement and multiple organ failure. (22466839)
2012
5
Histopathological diagnosis of Japanese spotted fever using formalin-fixed, paraffin-embedded skin biopsy specimens: usefulness of immunohistochemistry and real-time PCR analysis. (21668575)
2012
6
Predictive values of clinical parameters for severe Japanese spotted fever. (20827564)
2011
7
Serological survey of five zoonoses, scrub typhus, Japanese spotted fever, tularemia, Lyme disease, and Q fever, in feral raccoons (Procyon lotor) in Japan. (20553108)
2011
8
Japanese spotted fever with acute hepatic failure: was it associated with Epstein-Barr virus? (21091673)
2010
9
Surveillance, recognition, and reporting of Tsutsugamushi disease (scrub typhus) and Japanese spotted fever by general practice clinics in Miyazaki Prefecture, determined by questionnaire survey in 2007. (19688250)
2009
10
A case of Japanese spotted fever complicated with acute myocarditis. (17314430)
2007
11
The first fatal case of Japanese spotted fever confirmed by serological and microbiological tests in Awaji Island, Japan. (17642547)
2007
12
Epidemiological study of Japanese spotted fever and tsutsugamushi disease in Shimane Prefecture, Japan. (16785708)
2006
13
Japanese spotted fever, South Korea. (16836831)
2006
14
Simultaneous development of Japanese spotted fever in a married couple in Kagoshima Prefecture. (16922489)
2006
15
Epidemiology of tsutsugamushi disease and Japanese spotted fever in Kagoshima Prefecture, Japan. (16936351)
2006
16
Severe Japanese spotted fever successfully treated with fluoroquinolone. (17170509)
2006
17
Japanese spotted fever in Korea. (16082011)
2005
18
Clinical study of Japanese spotted fever and its aggravating factors. (12673413)
2003
19
Fulminant Japanese spotted fever definitively diagnosed by the polymerase chain reaction method. (12373493)
2002
20
Japanese spotted fever involving the central nervous system: two case reports and a literature review. (12354906)
2002
21
Fulminant Japanese spotted fever associated with hypercytokinemia. (11376087)
2001
22
Japanese spotted fever associated with multiorgan failure. (11810592)
2001
23
A patient with Japanese spotted fever complicated by meningoencephalitis. (11605191)
2001
24
Outbreak of Japanese spotted fever in the southeastern part of Awaji Island. (10783585)
2000
25
Japanese spotted fever cases in Kochi prefecture. (10777859)
2000
26
Japanese spotted fever in Shimane Prefecture - outbreak and place of infection. (10871919)
2000
27
The first reported case of Japanese spotted fever in Hiroshima Prefecture, Japan. (11135712)
2000
28
Japanese spotted fever: report of 31 cases and review of the literature. (9204291)
1997
29
First isolation of a rickettsia closely related to Japanese spotted fever pathogen from a tick in Japan. (8189407)
1994
30
Gelatin particle agglutination test for early serodiagnosis of Japanese spotted fever. (1603001)
1992
31
Serological studies of antigenic similarity between Japanese spotted fever rickettsiae and Weil-Felix test antigens. (1383270)
1992

Variations for Japanese Spotted Fever

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Expression for genes affiliated with Japanese Spotted Fever

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Search GEO for disease gene expression data for Japanese Spotted Fever.

Pathways for genes affiliated with Japanese Spotted Fever

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GO Terms for genes affiliated with Japanese Spotted Fever

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Biological processes related to Japanese Spotted Fever according to GeneCards Suite gene sharing:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1dicarboxylic acid metabolic processGO:004364810.2GOT1, GOT2
2glutamate catabolic process to 2-oxoglutarateGO:001955110.2GOT1, GOT2
3aspartate biosynthetic processGO:000653210.2GOT1, GOT2
4oxaloacetate metabolic processGO:000610710.2GOT1, GOT2
5glutamate metabolic processGO:000653610.2GOT1, GOT2
6aspartate metabolic processGO:000653110.1GOT1, GOT2
7biosynthetic processGO:000905810.1GOT1, GOT2
8positive regulation of endothelial cell proliferationGO:000193810.0CCL11, CCL2
9positive regulation of monocyte chemotaxisGO:009002610.0CCL2, CXCL10
10negative regulation of angiogenesisGO:001652510.0CCL2, CXCL10
11response to gamma radiationGO:00103329.9CCL2, CXCL10
12monocyte chemotaxisGO:00025489.6CCL11, CCL4
13cellular response to interferon-gammaGO:00713469.3CCL2, CCL4
14chemotaxisGO:00069359.1CCL11, CCL2, CXCL10
15positive regulation of inflammatory responseGO:00507299.0CCL11, CCL2, CCL4
16positive regulation of GTPase activityGO:00435478.9CCL11, CCL2, CCL4
17cell adhesionGO:00071558.8CCL11, CCL2, CCL4
18inflammatory responseGO:00069548.7CCL11, CCL4, CRP, CXCL10
19chemokine-mediated signaling pathwayGO:00700988.5CCL11, CCL2, CCL4, CXCL10
20cellular response to tumor necrosis factorGO:00713568.4CCL11, CCL2, CCL4
21G-protein coupled receptor signaling pathwayGO:00071868.3CCL11, CCL2, CCL4, CXCL10
22immune responseGO:00069558.2CCL11, CCL2, CCL4, CXCL10

Sources for Japanese Spotted Fever

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet