MCID: JPN001
MIFTS: 35

Japanese Spotted Fever malady

Category: Infectious diseases

Aliases & Classifications for Japanese Spotted Fever

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Aliases & Descriptions for Japanese Spotted Fever:

Name: Japanese Spotted Fever 10 12
Rickettsia Japonica Spotted Fever 10
 
Oriental Spotted Fever 10

Classifications:



External Ids:

Disease Ontology10 DOID:0050050

Summaries for Japanese Spotted Fever

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Disease Ontology:10 A spotted fever that has material basis in Rickettsia japonica, which is transmitted by ticks (Dermacentor taiwanensis and Haemaphysalis flava). The infection has symptom fever, has symptom eschars, has symptom regional adenopathy, and has symptom rash on extremities.

MalaCards based summary: Japanese Spotted Fever, also known as rickettsia japonica spotted fever, is related to diabetic ketoacidosis and neuritis, and has symptoms including fever, eschars and regional adenopathy. An important gene associated with Japanese Spotted Fever is YAP1 (Yes Associated Protein 1), and among its related pathways are CXCR3-mediated signaling events and A-beta Pathways: Uptake and Degradation. Affiliated tissues include liver, brain and heart, and related mouse phenotype immune system.

Wikipedia:68 Japanese spotted fever (or oriental spotted fever) is a condition characterized by a rash that has early... more...

Related Diseases for Japanese Spotted Fever

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Diseases related to Japanese Spotted Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 134)
idRelated DiseaseScoreTop Affiliating Genes
1diabetic ketoacidosis10.4CD40LG, CRP
2neuritis10.4CD40LG, CRP
3intracranial embolism10.4CD40LG, CRP
4fallopian tube carcinoma10.4CD40LG, CRP
5maxillary sinusitis10.4CD40LG, CRP
6peripheral nervous system disease10.4CD40LG, CRP
7malignant otitis externa10.4CD40LG, CRP
8rhinoscleroma10.4CD40LG, CRP
9rumination disorder10.4CD40LG, CRP
10blepharophimosis10.4CCL11, CRP
11keratoderma hereditarium mutilans with ichthyosis10.4CD40LG, CRP
12inflammatory leiomyosarcoma10.4CD40LG, CRP
13intestinal impaction10.4CD40LG, CRP
14diffuse secondary choroid atrophy10.4CD40LG, CRP
15temporal arteritis10.4CD40LG, CRP
16focal labyrinthitis10.4CD40LG, CRP
17hemosiderosis10.4CD40LG, CRP
18splenic infarction10.4CD40LG, CRP
19narcissistic personality disorder10.4CD40LG, CRP
20melorheostosis10.4CCL11, CD40LG
21peripheral artery disease10.4CD40LG, CRP
22tricuspid valve disease10.4CD40LG, CRP
23social phobia10.4CD40LG, CRP
24vascular skin disease10.3CD40LG, GOT1
25hymenolepiasis10.3CD40LG, SERPINC1
26fowler's syndrome10.3CD40LG, SERPINC1
27neuroretinitis10.3CD40LG, CRP
28constant exophthalmos10.3CD40LG, CRP
29nephropathia epidemica10.3CD40LG, SERPINC1
30endocarditis10.3CRP, CXCL10
31autoimmune disease of blood10.3CD40LG, GOT1
32abducens nerve neoplasm10.3CRP, SERPINC1
33hemorrhagic proctocolitis10.3CD40LG, SERPINC1
34malignant mesenchymoma10.3CCL2, CD40LG
35aggressive digital papillary adenocarcinoma10.3CRP, CXCL10
36endemic goiter10.3CRP, CXCL10
37lacrimal system cancer10.3CD40LG, CXCL10
38urethral villous adenoma10.2GOT1, GOT2
39descending colon cancer10.2GOT1, GOT2
40peptic ulcer disease10.2CD40LG, CRP
41mesocestoidiasis10.2GOT1, GOT2
42colon carcinoma in situ10.2GOT1, GOT2
43congenital chloride diarrhea10.2CRP, SERPINC1
44venezuelan hemorrhagic fever10.2GOT1, GOT2
45postcholecystectomy syndrome10.2CCL11, CD40LG
46diamond-blackfan anemia 410.2GOT1, GOT2
47kluver-bucy syndrome10.2GOT1, GOT2
48prolapse of female genital organ10.2GOT1, GOT2
49crescentic glomerulonephritis10.2CCL2, CD40LG
50inclusion body myositis10.2GOT1, GOT2

Graphical network of the top 20 diseases related to Japanese Spotted Fever:



Diseases related to japanese spotted fever

Symptoms for Japanese Spotted Fever

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Symptoms:

 10
  • fever
  • eschars
  • regional adenopathy
  • rash on extremities

Drugs & Therapeutics for Japanese Spotted Fever

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Japanese Spotted Fever

Genetic Tests for Japanese Spotted Fever

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Anatomical Context for Japanese Spotted Fever

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MalaCards organs/tissues related to Japanese Spotted Fever:

33
Liver, Brain, Heart, Lung

Animal Models for Japanese Spotted Fever or affiliated genes

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MGI Mouse Phenotypes related to Japanese Spotted Fever:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.6CCL11, CCL2, CD40LG, CRP, CXCL10, SERPINC1

Publications for Japanese Spotted Fever

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Articles related to Japanese Spotted Fever:

(show all 31)
idTitleAuthorsYear
1
Psychiatric comorbities in comorbid bipolar disorder and obsessive-compulsive disorder patients. (27208451)
2016
2
Spectrum of Cutaneous Vasculitis in Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss): A Case Series. (25079200)
2014
3
Seven strains of mice as potential models of bovine pasteurellosis following intranasal challenge with a bovine pneumonic strain of Pasteurella multocida A:3; comparisons of disease and pathological outcomes. (23415879)
2013
4
The anticancer drug tamoxifen counteracts the pathology in a mouse model of duchenne muscular dystrophy. (23332367)
2013
5
Attitudes and behaviour regarding deep dentin caries removal: a survey among German dentists. (23899958)
2013
6
Carotid endarterectomy for treatment of tandem carotid stenosis in the presence of the anomalous origin of the occipital artery arising from the cervical internal carotid artery: a case report. (24199618)
2013
7
Surgical management of diabetic retinopathy. (24339677)
2013
8
Gastric bypass surgery as an intervention for obese patients with hemochromatosis. (22543684)
2012
9
Vitamin D receptor genetic polymorphisms and tuberculosis among Chinese Han ethnic group. (22490597)
2012
10
Serial head circumference and neurodevelopmental screening after surgical correction for single- and multiple-suture craniosynostosis. (22034904)
2012
11
Endothelium-derived neuregulin protects the heart against ischemic injury. (21555713)
2011
12
Long FLT3 internal tandem duplications and reduced PML-RARI+ expression at diagnosis characterize a high-risk subgroup of acute promyelocytic leukemia patients. (20133893)
2010
13
A novel point variant in NTRK3, R645C, suggests a role of this gene in the pathogenesis of Hirschsprung disease. (19040714)
2009
14
Utility of flexor carpi radialis h-reflex in diagnosis of cervical radiculopathy. (19952573)
2009
15
Prevalence of non-alcoholic fatty liver disease in urban south Indians in relation to different grades of glucose intolerance and metabolic syndrome. (19168251)
2009
16
The influence of acute-phase levels of haemostatic factors on reperfusion and mortality in patients with acute myocardial infarction treated with streptokinase. (17721741)
2008
17
GABA inhibition of cyclic AMP production in immortalized GnRH neurons is mediated by calcineurin-dependent dephosphorylation of adenylyl cyclase 9. (17551263)
2007
18
The effect of recombinant human intrinsic factor on the uptake of vitamin B12 in patients with evident vitamin B12 deficiency. (16704961)
2006
19
Pathobiology of pulmonary arterial hypertension. (15615096)
2004
20
Analysis of transcriptional regulation of the small leucine rich proteoglycans. (15496828)
2004
21
Prospective, randomized, double-blind trial investigating the effect of doxycycline on matrix metalloproteinase expression within atherosclerotic carotid plaques. (12468782)
2002
22
Non-steroidal anti-inflammatory drugs inhibit matrix metalloproteinase-2 expression via repression of transcription in lung cancer cells. (11728453)
2001
23
Mucoepidermoid carcinoma of the conjunctiva: a series of three cases. (10768346)
2000
24
Existence of a differentiation blockage at the stage of a megakaryocyte precursor in the thrombocytopenia and absent radii (TAR) syndrome. (10688818)
2000
25
MRI findings in the liver in biliary atresia patients after the Kasai operation. (9149355)
1997
26
Regulation of cytochrome P450 cholesterol side-chain cleavage, 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase type 1 and estradiol-17 beta-hydroxysteroid dehydrogenase mRNA levels by calcium in human choriocarcinoma JEG-3 cells. (9359473)
1997
27
The prognostic inflammatory and nutritional index in traumatized patients receiving enteral nutrition support. (1910063)
1991
28
Regional brain glucose metabolism in neuroacanthocytosis. (2788833)
1989
29
Personality in frozen shoulder. (1234412)
1975
30
SUBCLAVIAN STEAL SYNDROME. (14252366)
1964
31
Penicillin treatment of experimental yaws in rabbits with special reference to criteria of infection and cure. (12996733)
1952

Variations for Japanese Spotted Fever

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Expression for genes affiliated with Japanese Spotted Fever

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Search GEO for disease gene expression data for Japanese Spotted Fever.

Pathways for genes affiliated with Japanese Spotted Fever

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GO Terms for genes affiliated with Japanese Spotted Fever

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Biological processes related to Japanese Spotted Fever according to GeneCards Suite gene sharing:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1dicarboxylic acid metabolic processGO:004364810.2GOT1, GOT2
2glutamate catabolic process to 2-oxoglutarateGO:001955110.2GOT1, GOT2
3aspartate biosynthetic processGO:000653210.2GOT1, GOT2
4oxaloacetate metabolic processGO:000610710.2GOT1, GOT2
5glutamate metabolic processGO:000653610.2GOT1, GOT2
6aspartate metabolic processGO:000653110.1GOT1, GOT2
7biosynthetic processGO:000905810.1GOT1, GOT2
8positive regulation of endothelial cell proliferationGO:000193810.0CCL11, CCL2
9positive regulation of monocyte chemotaxisGO:009002610.0CCL2, CXCL10
10negative regulation of angiogenesisGO:001652510.0CCL2, CXCL10
11response to gamma radiationGO:00103329.9CCL2, CXCL10
12monocyte chemotaxisGO:00025489.6CCL11, CCL4
13cellular response to interferon-gammaGO:00713469.3CCL2, CCL4
14chemotaxisGO:00069359.1CCL11, CCL2, CXCL10
15positive regulation of inflammatory responseGO:00507299.0CCL11, CCL2, CCL4
16positive regulation of GTPase activityGO:00435478.9CCL11, CCL2, CCL4
17cell adhesionGO:00071558.8CCL11, CCL2, CCL4
18inflammatory responseGO:00069548.7CCL11, CCL4, CRP, CXCL10
19chemokine-mediated signaling pathwayGO:00700988.5CCL11, CCL2, CCL4, CXCL10
20cellular response to tumor necrosis factorGO:00713568.4CCL11, CCL2, CCL4
21G-protein coupled receptor signaling pathwayGO:00071868.3CCL11, CCL2, CCL4, CXCL10
22immune responseGO:00069558.2CCL11, CCL2, CCL4, CXCL10

Sources for Japanese Spotted Fever

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet