MCID: JPN001
MIFTS: 31

Japanese Spotted Fever malady

Category: Infectious diseases

Aliases & Classifications for Japanese Spotted Fever

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Aliases & Descriptions for Japanese Spotted Fever:

Name: Japanese Spotted Fever 11 13
Rickettsia Japonica Spotted Fever 11
 
Oriental Spotted Fever 11

Classifications:



External Ids:

Disease Ontology11 DOID:0050050

Summaries for Japanese Spotted Fever

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Disease Ontology:11 A spotted fever that has material basis in rickettsia japonica, which is transmitted by ticks (dermacentor taiwanensis and haemaphysalis flava). the infection has symptom fever, has symptom eschars, has symptom regional adenopathy, and has symptom rash on extremities.

MalaCards based summary: Japanese Spotted Fever, also known as rickettsia japonica spotted fever, is related to social phobia and trachoma, and has symptoms including fever, eschars and regional adenopathy. An important gene associated with Japanese Spotted Fever is AFF2 (AF4/FMR2 Family Member 2), and among its related pathways are CXCR3-mediated signaling events and NF-kappa B signaling pathway. Affiliated tissues include testes and skin.

Wikipedia:69 Japanese spotted fever (or oriental spotted fever) is a condition characterized by a rash that has early... more...

Related Diseases for Japanese Spotted Fever

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Diseases related to Japanese Spotted Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 109)
idRelated DiseaseScoreTop Affiliating Genes
1social phobia10.7AFF2, CD40LG
2trachoma10.7AFF2, CD40LG
3far eastern spotted fever10.7CD40LG, PLEKHG4
4erysipeloid10.7AFF2, CD40LG
5aneruptive fever10.6AFF2, CD40LG
6spotted fever10.5
7bone cancer10.5CD40LG, CRP
8dehydration polycythemia10.5CD40LG, CRP
9calcinosis10.5CD40LG, CRP
10fallopian tube leiomyosarcoma10.5CD40LG, CRP
11small intestinal vasoactive intestinal peptide producing tumor10.5CD40LG, CRP
12beach ear10.5CD40LG, CRP
13post-traumatic stress disorder10.5CD40LG, CRP
14hepatic vein thrombosis10.5CD40LG, CRP
15acquired thrombocytopenia10.5CD40LG, CRP
16conventional leiomyosarcoma10.5CD40LG, CRP
17cyclothymic disorder10.5CD40LG, CRP
18solitary cyst of breast10.5CCL11, CRP
19polyarteritis nodosa10.5CD40LG, CRP
20heart disease10.4CD40LG, KANTR
21gait apraxia10.4CCL11, CD40LG
22chromoblastomycosis10.4CD40LG, CRP
23rickettsialpox10.4CD40LG, KANTR
24pompholyx10.4CD40LG, KANTR
25facial nerve neoplasm10.4CD40LG, KANTR
26pyrimidine metabolic disorder10.4CD40LG, CRP
27gastric hemangioma10.4CD40LG, CRP
28brachial plexus neuropathy10.4CD40LG, KANTR
29artery disease10.4CD40LG, CRP
30capillary hemangioma10.4CD40LG, CXCL10
31juvenile dermatitis herpetiformis10.4CCL11, CD40LG
32rickettsia parkeri spotted fever10.4AFF2, CD40LG, PLEKHG4
33sennetsu fever10.4AFF2, CD40LG, PLEKHG4
34urinary schistosomiasis10.4CD40LG, KANTR
35american histoplasmosis10.4CD40LG, KANTR
36balantidiasis10.4CD40LG, CRP
37spondylosis10.4CD40LG, CRP
38lynch syndrome10.4CD40LG, KANTR
39myelomeningocele10.3CRP, KANTR
40early congenital syphilis10.3CD40LG, CRP
41diphyllobothriasis10.3CD40LG, SERPINC1
42marek disease10.3CD40LG, SERPINC1
43hepatic fibrosis renal cysts mental retardation10.3CD40LG, SERPINC1
44compensatory emphysema10.3CD40LG, CRP
45borst-jadassohn intraepidermal carcinoma10.3CCL11, CD40LG
46steroid-induced glaucoma10.3CD40LG, CRP
47intestinal pseudo-obstruction10.3CD40LG, KANTR
48dentin dysplasia10.3CD40LG, CXCL10
49substernal goiter10.3CRP, CXCL10
50prostatic hypertrophy10.3CD40LG, SERPINC1

Graphical network of the top 20 diseases related to Japanese Spotted Fever:



Diseases related to japanese spotted fever

Symptoms for Japanese Spotted Fever

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Symptoms:

 11
  • f
  • e
  • r

Drugs & Therapeutics for Japanese Spotted Fever

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Japanese Spotted Fever

Genetic Tests for Japanese Spotted Fever

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Anatomical Context for Japanese Spotted Fever

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MalaCards organs/tissues related to Japanese Spotted Fever:

34
Testes, Skin

Animal Models for Japanese Spotted Fever or affiliated genes

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Publications for Japanese Spotted Fever

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Articles related to Japanese Spotted Fever:

(show all 31)
idTitleAuthorsYear
1
Improvement in early diagnosis of Japanese spotted fever by using a novel Rick PCR system. (26130479)
2015
2
Significantly higher cytokine and chemokine levels in patients with Japanese spotted fever than in those with Tsutsugamushi disease. (24671792)
2014
3
A neonatal case of Japanese spotted fever. (23743544)
2013
4
Histopathological diagnosis of Japanese spotted fever using formalin-fixed, paraffin-embedded skin biopsy specimens: usefulness of immunohistochemistry and real-time PCR analysis. (21668575)
2012
5
A case of Japanese spotted fever complicated with central nervous system involvement and multiple organ failure. (22466839)
2012
6
Predictive values of clinical parameters for severe Japanese spotted fever. (20827564)
2011
7
Serological survey of five zoonoses, scrub typhus, Japanese spotted fever, tularemia, Lyme disease, and Q fever, in feral raccoons (Procyon lotor) in Japan. (20553108)
2011
8
Japanese spotted fever with acute hepatic failure: was it associated with Epstein-Barr virus? (21091673)
2010
9
Surveillance, recognition, and reporting of Tsutsugamushi disease (scrub typhus) and Japanese spotted fever by general practice clinics in Miyazaki Prefecture, determined by questionnaire survey in 2007. (19688250)
2009
10
A case of Japanese spotted fever complicated with acute myocarditis. (17314430)
2007
11
The first fatal case of Japanese spotted fever confirmed by serological and microbiological tests in Awaji Island, Japan. (17642547)
2007
12
Simultaneous development of Japanese spotted fever in a married couple in Kagoshima Prefecture. (16922489)
2006
13
Epidemiology of tsutsugamushi disease and Japanese spotted fever in Kagoshima Prefecture, Japan. (16936351)
2006
14
Epidemiological study of Japanese spotted fever and tsutsugamushi disease in Shimane Prefecture, Japan. (16785708)
2006
15
Japanese spotted fever, South Korea. (16836831)
2006
16
Severe Japanese spotted fever successfully treated with fluoroquinolone. (17170509)
2006
17
Japanese spotted fever in Korea. (16082011)
2005
18
Clinical study of Japanese spotted fever and its aggravating factors. (12673413)
2003
19
Fulminant Japanese spotted fever definitively diagnosed by the polymerase chain reaction method. (12373493)
2002
20
Japanese spotted fever involving the central nervous system: two case reports and a literature review. (12354906)
2002
21
A patient with Japanese spotted fever complicated by meningoencephalitis. (11605191)
2001
22
Fulminant Japanese spotted fever associated with hypercytokinemia. (11376087)
2001
23
Japanese spotted fever associated with multiorgan failure. (11810592)
2001
24
Outbreak of Japanese spotted fever in the southeastern part of Awaji Island. (10783585)
2000
25
Japanese spotted fever cases in Kochi prefecture. (10777859)
2000
26
Japanese spotted fever in Shimane Prefecture - outbreak and place of infection. (10871919)
2000
27
The first reported case of Japanese spotted fever in Hiroshima Prefecture, Japan. (11135712)
2000
28
Japanese spotted fever: report of 31 cases and review of the literature. (9204291)
1997
29
First isolation of a rickettsia closely related to Japanese spotted fever pathogen from a tick in Japan. (8189407)
1994
30
Serological studies of antigenic similarity between Japanese spotted fever rickettsiae and Weil-Felix test antigens. (1383270)
1992
31
Gelatin particle agglutination test for early serodiagnosis of Japanese spotted fever. (1603001)
1992

Variations for Japanese Spotted Fever

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Expression for genes affiliated with Japanese Spotted Fever

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Search GEO for disease gene expression data for Japanese Spotted Fever.

Pathways for genes affiliated with Japanese Spotted Fever

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GO Terms for genes affiliated with Japanese Spotted Fever

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Cellular components related to Japanese Spotted Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056156.9CCL11, CCL4, CCL4L1, CD40LG, CRP, CXCL10

Biological processes related to Japanese Spotted Fever according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1lymphocyte chemotaxisGO:004824710.2CCL11, CCL4L1
2positive regulation of inflammatory responseGO:00507299.4CCL11, CCL4, CCL4L1
3monocyte chemotaxisGO:00025489.4CCL11, CCL4, CCL4L1
4cellular response to interleukin-1GO:00713479.3CCL11, CCL4, CCL4L1
5cellular response to tumor necrosis factorGO:00713569.2CCL11, CCL4, CCL4L1
6neutrophil chemotaxisGO:00305939.2CCL11, CCL4, CCL4L1
7cellular response to interferon-gammaGO:00713469.2CCL11, CCL4, CCL4L1
8positive regulation of ERK1 and ERK2 cascadeGO:00703748.9CCL11, CCL4, CCL4L1
9response to virusGO:00096158.6CCL11, CCL4, CXCL10
10chemokine-mediated signaling pathwayGO:00700988.5CCL11, CCL4, CCL4L1, CXCL10
11inflammatory responseGO:00069547.5CCL11, CCL4, CCL4L1, CD40LG, CRP, CXCL10

Molecular functions related to Japanese Spotted Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1CCR chemokine receptor bindingGO:004802010.0CCL11, CCL4L1
2chemokine activityGO:00080098.4CCL11, CCL4, CCL4L1, CXCL10

Sources for Japanese Spotted Fever

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet