MCID: JPN001
MIFTS: 30

Japanese Spotted Fever malady

Categories: Infectious diseases

Aliases & Classifications for Japanese Spotted Fever

Aliases & Descriptions for Japanese Spotted Fever:

Name: Japanese Spotted Fever 12 14
Rickettsia Japonica Spotted Fever 12
Oriental Spotted Fever 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050050

Summaries for Japanese Spotted Fever

Disease Ontology : 12 A spotted fever that has material basis in Rickettsia japonica, which is transmitted_by ticks (Dermacentor taiwanensis and Haemaphysalis flava). The infection has symptom fever, has symptom eschars, has symptom regional adenopathy, and has symptom rash on extremities.

MalaCards based summary : Japanese Spotted Fever, also known as rickettsia japonica spotted fever, is related to spotted fever and exanthem, and has symptoms including fever, eschars and regional adenopathy. An important gene associated with Japanese Spotted Fever is AFF2 (AF4/FMR2 Family Member 2), and among its related pathways/superpathways are PAK Pathway and Akt Signaling. Affiliated tissues include testes and skin.

Wikipedia : 71 Japanese spotted fever (or oriental spotted fever) is a condition characterized by a rash that has early... more...

Related Diseases for Japanese Spotted Fever

Diseases related to Japanese Spotted Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 84)
id Related Disease Score Top Affiliating Genes
1 spotted fever 30.9 CD40LG KANTR
2 exanthem 10.3 AFF2 PLEKHG4
3 rabies 10.3 AFF2 CD40LG
4 flinders island spotted fever 10.3 CD40LG PLEKHG4
5 hemorrhagic fever with renal syndrome 10.3 AFF2 CD40LG
6 pestis minor 10.3 AFF2 CD40LG
7 polycythemia due to hypoxia 10.2 CD40LG CRP
8 cannabis dependence 10.2 CD40LG CRP
9 leiomyosarcoma 10.2 CD40LG CRP
10 chronic mucocutaneous candidiasis 10.2 CD40LG CRP
11 spinal canal and spinal cord meningioma 10.2 CD40LG KANTR
12 ovarian serous cystadenocarcinoma 10.2 CD40LG CRP
13 amyotrohpic lateral sclerosis type 22 10.2 CD40LG CXCL10
14 chronic fungal otitis externa 10.2 CD40LG CRP
15 facial nerve neoplasm 10.2 CD40LG KANTR
16 hypertensive heart disease 10.2 CD40LG CRP
17 human immunodeficiency virus infectious disease 10.2 CD40LG CRP
18 spastic ataxia 7, autosomal dominant 10.2 CD40LG KANTR
19 homocystinuria 10.2 CD40LG KANTR
20 natural killer cell leukemia 10.2 CCL11 CRP
21 rocky mountain spotted fever 10.2 AFF2 CD40LG PLEKHG4
22 dyskeratosis congenita 10.2 CD40LG CXCL10
23 anal canal adenocarcinoma 10.2 CD40LG KANTR
24 cyclotropia 10.2 CD40LG CRP
25 pseudohypoaldosteronism, type iic 10.2 CD40LG CXCL10
26 retinal degeneration 10.2 CD40LG CRP
27 cysticercosis 10.2 CD40LG SERPINC1
28 freiberg's disease 10.2 CD40LG SERPINC1
29 hereditary endotheliopathy, retinopathy, nephropathy, and stroke 10.2 CD40LG SERPINC1
30 benign paroxysmal positional nystagmus 10.2 CD40LG KANTR
31 dysplastic nevus syndrome 10.2 CD40LG CXCL10
32 cardiovascular cancer 10.2 CD40LG KANTR
33 megaloblastic anemia 10.2 CD40LG CRP
34 dermatomycosis 10.1 CD40LG CRP
35 temtamy syndrome 10.1 CD40LG CXCL10
36 omphalocele 10.1 CRP KANTR
37 bazex syndrome 10.1 CRP KANTR
38 glycogen storage disease viii 10.1 CD40LG CRP
39 cataract 10.1 CRP SERPINC1
40 czech dysplasia 10.1 CD40LG SERPINC1
41 hidrocystoma 10.1 CD40LG KANTR
42 midline cystocele 10.1 CRP SERPINC1
43 primrose syndrome 10.1 CRP KANTR
44 chorioretinal scar 10.1 KANTR SERPINC1
45 constant exophthalmos 10.1 CCL4 CCL4L1
46 secretory diarrhea myopathy and deafness 10.1 CRP SERPINC1
47 epstein-barr virus hepatitis 10.1 CD40LG SERPINC1
48 sennetsu fever 10.1 AFF2 CD40LG
49 acute chest syndrome 10.1 CCL11 CD40LG CRP
50 benjamin syndrome 10.1 CD40LG CXCL10

Graphical network of the top 20 diseases related to Japanese Spotted Fever:



Diseases related to Japanese Spotted Fever

Symptoms & Phenotypes for Japanese Spotted Fever

Symptoms:

12
  • fever
  • eschars
  • regional adenopathy
  • rash on extremities

Drugs & Therapeutics for Japanese Spotted Fever

Search Clinical Trials , NIH Clinical Center for Japanese Spotted Fever

Genetic Tests for Japanese Spotted Fever

Anatomical Context for Japanese Spotted Fever

MalaCards organs/tissues related to Japanese Spotted Fever:

39
Testes, Skin

Publications for Japanese Spotted Fever

Articles related to Japanese Spotted Fever:

(show all 31)
id Title Authors Year
1
Improvement in early diagnosis of Japanese spotted fever by using a novel Rick PCR system. ( 26130479 )
2015
2
Significantly higher cytokine and chemokine levels in patients with Japanese spotted fever than in those with Tsutsugamushi disease. ( 24671792 )
2014
3
A neonatal case of Japanese spotted fever. ( 23743544 )
2013
4
A case of Japanese spotted fever complicated with central nervous system involvement and multiple organ failure. ( 22466839 )
2012
5
Histopathological diagnosis of Japanese spotted fever using formalin-fixed, paraffin-embedded skin biopsy specimens: usefulness of immunohistochemistry and real-time PCR analysis. ( 21668575 )
2012
6
Serological survey of five zoonoses, scrub typhus, Japanese spotted fever, tularemia, Lyme disease, and Q fever, in feral raccoons (Procyon lotor) in Japan. ( 20553108 )
2011
7
Predictive values of clinical parameters for severe Japanese spotted fever. ( 20827564 )
2011
8
Japanese spotted fever with acute hepatic failure: was it associated with Epstein-Barr virus? ( 21091673 )
2010
9
Surveillance, recognition, and reporting of Tsutsugamushi disease (scrub typhus) and Japanese spotted fever by general practice clinics in Miyazaki Prefecture, determined by questionnaire survey in 2007. ( 19688250 )
2009
10
The first fatal case of Japanese spotted fever confirmed by serological and microbiological tests in Awaji Island, Japan. ( 17642547 )
2007
11
A case of Japanese spotted fever complicated with acute myocarditis. ( 17314430 )
2007
12
Severe Japanese spotted fever successfully treated with fluoroquinolone. ( 17170509 )
2006
13
Simultaneous development of Japanese spotted fever in a married couple in Kagoshima Prefecture. ( 16922489 )
2006
14
Japanese spotted fever, South Korea. ( 16836831 )
2006
15
Epidemiology of tsutsugamushi disease and Japanese spotted fever in Kagoshima Prefecture, Japan. ( 16936351 )
2006
16
Epidemiological study of Japanese spotted fever and tsutsugamushi disease in Shimane Prefecture, Japan. ( 16785708 )
2006
17
Japanese spotted fever in Korea. ( 16082011 )
2005
18
Clinical study of Japanese spotted fever and its aggravating factors. ( 12673413 )
2003
19
Japanese spotted fever involving the central nervous system: two case reports and a literature review. ( 12354906 )
2002
20
Fulminant Japanese spotted fever definitively diagnosed by the polymerase chain reaction method. ( 12373493 )
2002
21
Fulminant Japanese spotted fever associated with hypercytokinemia. ( 11376087 )
2001
22
Japanese spotted fever associated with multiorgan failure. ( 11810592 )
2001
23
A patient with Japanese spotted fever complicated by meningoencephalitis. ( 11605191 )
2001
24
The first reported case of Japanese spotted fever in Hiroshima Prefecture, Japan. ( 11135712 )
2000
25
Japanese spotted fever in Shimane Prefecture - outbreak and place of infection. ( 10871919 )
2000
26
Outbreak of Japanese spotted fever in the southeastern part of Awaji Island. ( 10783585 )
2000
27
Japanese spotted fever cases in Kochi prefecture. ( 10777859 )
2000
28
Japanese spotted fever: report of 31 cases and review of the literature. ( 9204291 )
1997
29
First isolation of a rickettsia closely related to Japanese spotted fever pathogen from a tick in Japan. ( 8189407 )
1994
30
Serological studies of antigenic similarity between Japanese spotted fever rickettsiae and Weil-Felix test antigens. ( 1383270 )
1992
31
Gelatin particle agglutination test for early serodiagnosis of Japanese spotted fever. ( 1603001 )
1992

Variations for Japanese Spotted Fever

Expression for Japanese Spotted Fever

Search GEO for disease gene expression data for Japanese Spotted Fever.

Pathways for Japanese Spotted Fever

GO Terms for Japanese Spotted Fever

Cellular components related to Japanese Spotted Fever according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.17 CCL11 CCL4 CCL4L1 CD40LG CRP CXCL10

Biological processes related to Japanese Spotted Fever according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.78 CCL11 CCL4 CD40LG CXCL10
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.67 CCL11 CCL4 CCL4L1
3 chemotaxis GO:0006935 9.63 CCL11 CCL4 CXCL10
4 cellular response to tumor necrosis factor GO:0071356 9.61 CCL11 CCL4 CCL4L1
5 response to virus GO:0009615 9.58 CCL11 CCL4 CXCL10
6 cellular response to interleukin-1 GO:0071347 9.54 CCL11 CCL4 CCL4L1
7 lymphocyte chemotaxis GO:0048247 9.51 CCL11 CCL4L1
8 neutrophil chemotaxis GO:0030593 9.5 CCL11 CCL4 CCL4L1
9 cellular response to interferon-gamma GO:0071346 9.43 CCL11 CCL4 CCL4L1
10 monocyte chemotaxis GO:0002548 9.33 CCL11 CCL4 CCL4L1
11 chemokine-mediated signaling pathway GO:0070098 9.26 CCL11 CCL4 CCL4L1 CXCL10
12 inflammatory response GO:0006954 9.1 CCL11 CCL4 CCL4L1 CD40LG CRP CXCL10

Molecular functions related to Japanese Spotted Fever according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 CCL11 CCL4 CD40LG CXCL10
2 CCR chemokine receptor binding GO:0048020 9.16 CCL11 CCL4L1
3 chemokine activity GO:0008009 8.92 CCL11 CCL4 CCL4L1 CXCL10

Sources for Japanese Spotted Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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