Jaundice malady

MedlinePlus: Jaundice causes your skin and the whites of your eyes to turn yellow. too much bilirubin causes jaundice. bilirubin is a yellow chemical in hemoglobin, the substance that carries oxygen in your red blood cells. as red blood cells break down, your body builds new cells to replace them. the old ones are processed by the liver. if the liver cannot handle the blood cells as they break down, bilirubin builds up in the body and your skin may look yellow. many healthy babies have some jaundice during the first week of life. it usually goes away. however, jaundice can happen at any age and may be a sign of a problem. jaundice can happen for many reasons, such as: blood diseases genetic syndromes liver diseases, such as hepatitis or cirrhosis blockage of bile ducts infections medicines²³

MalaCards: Jaundice, also known as icterus, is related to obstructive jaundice and neonatal jaundice. An important gene associated with Jaundice is G6PD (glucose-6-phosphate dehydrogenase), and among its related pathways are Bacterial infections in CF airways and RAR-Gamma-RXR-Alpha Degradation. The compounds cyclophosphamide and n acetylcysteine have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and bone marrow, and related mouse phenotypes are respiratory system and endocrine/exocrine gland.

Wikipedia: Jaundice (also known as icterus; from the Greek word ίκτερος, attributive adjective: icteric) is...⁴⁴ more...

jaundice 17 23 icterus 43

Diseases related to jaundice by text searches and GeneDecks gene sharing:

(show top 50)    (show all 977)

id	Related Disease	Score	Top Affiliating Genes
1	obstructive jaundice	36.3	ALPP, SLC25A13, GGT1
2	neonatal jaundice	36.0	UGT1A1, JAG1, GUSB, HMOX1, NR1I3, RHD
3	gilbert syndrome	32.2	UGT1A, UGT1A1, UGT1A4, UGT1A7, G6PD
4	hepatitis	31.2	GPT, IFNA1, SLC17A5
5	crigler-najjar syndrome	29.7	UGT1A, UGT1A1, UGT1A4, UGT1A6, UGT1A9, GPT
6	hepatic tuberculosis	29.7	F2, ALB, ALPP, GGT1
7	crimean-congo hemorrhagic fever	29.6	IL6, GPT, F2, TNF, SLC17A5
8	hereditary spherocytosis	29.6	UGT1A1, F5, HP, PKLR, RHD, G6PD
9	hepatitis e	28.6	GPT, IFNA1, F2, ALB, ALPP, G6PD
10	hepatitis d	28.3	GPT, IFNA1, F2, TNF, SLC35A2, SLC17A5
11	leptospirosis	28.2	CD79A, IL10, IL18, IL1B, IL1R1, IL1RN
12	acute liver failure	28.2	GPT, F2, ALB, SLC17A5, HGF
13	gallbladder carcinoma	28.1	CEACAM3, GSTM1, GSTT1, IL1B, IL1RN, IL6
14	hypertrophic pyloric stenosis	28.0	BLVRB, UGT1A1, IGF1, HMOX2, TGFB1
15	pyloric stenosis	28.0	BLVRB, UGT1A1, IGF1, HMOX2, TGFB1
16	alcoholic hepatitis	27.9	IL10, IL8, F2, TNF, HGF
17	galactosemia	27.8	BTD, G6PD, TF, SLC25A13, GALK1, GALT
18	hemophagocytic lymphohistiocytosis	27.8	IL18, IL2, IL2RA, IL8, CCL2, GPT
19	crigler najjar syndrome, type 2	27.8	UGT1A1, UGT1A4, UGT1A6, UGT1A9, GPT
20	pancreatic diseases	27.6	SCT, UGT1A7, CEL, GSTM1, IL6, IL8
21	cholangiocarcinoma	27.6	SELL, CLDN4, SCT, CEACAM3, FUT4, CD14
22	alpha thalassemia	27.5	UGT1A1, HP, G6PD, HBB, TF
23	alagille syndrome	27.3	LCAT, ATP8B1, JAG1, ALB, HP, ABCB11
24	beta thalassemia	27.2	UGT1A1, GSR, RHD, G6PD, HBB, TF
25	septooptic dysplasia	27.1	GH1, PROP1, SOD1
26	stomach carcinoma	26.9	UGT1A1, CEACAM3, GSTM1, GSTT1, IL10, IL18
27	hepatitis c	26.8	ASGR2, GSR, IL10, IL18, IL2, GPT
28	autoimmune hemolytic anemia	26.7	CD79A, IL10, IL2, IL2RA, IFNA1, F5
29	hepatitis b	26.7	ASGR2, IL10, IL18, IL2RA, GPT, IFNA1
30	kernicterus	26.7	UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6
31	autoimmune pancreatitis	26.4	IL10, IL2RA, ALB, HLA-DQB1, HLA-DRB1, TNF
32	thrombotic thrombocytopenic purpura, acquired	26.4	IL2, F2, HP, HLA-DQB1, HLA-DRB1, THBD
33	alpha 1-antitrypsin deficiency	26.3	CD14, IL10, IL8, CCL2, F2, GLUD1
34	typhoid fever	26.3	CD79A, IL1B, IL1R1, GPT, F2, HLA-DQB1
35	liver cancer	26.2	XDH, CEACAM3, IL2, IL6, GPT, IFNA1
36	alcoholism	26.0	SCT, LBR, GSR, IL1RN, CCK, GPT
37	hepatitis a	25.9	CD79A, IL10, IL1B, IL2, IL2RA, APP
38	pancreatic carcinoma	25.5	CLDN4, SCT, CEACAM3, IL10, IL18, IL1B
39	cholestasis	24.7	BLVRA, SCT, CIRH1A, UGT1A3, LCAT, LAP3
40	pancreatic cancer	24.6	REN, CLDN4, SCT, UGT1A1, UGT1A7, UGT1A9
41	liver cirrhosis	23.8	REN, SCT, UGT1A, UGT1A7, LCAT, LBP
42	intrahepatic cholestasis of pregnancy	23.8	LAP3, ATP8B1, IL2RA, GPT, F2, HLA-DQA1
43	thalassemia	23.6	UGT1A, UGT1A1, GSR, GSTM1, GSTT1, IL1B
44	viral hepatitis	23.5	UGT1A, LCAT, LAP3, CD14, ITGAL, GSR
45	hypothyroidism	23.3	REN, BTD, UCP2, CEACAM3, CD79A, GSR
46	blindness	22.7	REN, SCT, UGT1A1, UCP2, XDH, CEACAM3
47	biliary atresia	22.3	ATP8B1, JAG1, CD14, IL10, IL18, IL1B
48	nephropathy	20.0	REN, SELL, UCP2, LCAT, LBR, LAP3
49	malaria	20.0	REN, SEC23B, LCAT, LAP3, XDH, ITGAL
50	gastric cancer	18.5	BTD, SELL, SEC23B, CLDN4, UGT1A1, UGT1A6

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to jaundice:

²²

MGI Mouse Phenotypes related to jaundice:

²⁵ (show all 21)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	9.8	PROP1, HMOX2, ARNTL, CD14, UCP2, SEC23B
2	endocrine/exocrine gland phenotype	MP:0005379	9.8	IL2, SELL, SEC23B, XDH, GUSB, GLUD1
3	skeleton phenotype	MP:0005390	9.8	HBB, SRF, AKR1A1, IGF1, IL6, IL1R1
4	renal/urinary system phenotype	MP:0005367	9.7	ARNTL, OXT, NPPA, SLC25A13, REN, HBB
5	no phenotypic analysis	MP:0003012	9.5	SLC25A13, NTS, SRF, MADCAM1, IL25, ITGAX
6	digestive/alimentary phenotype	MP:0005381	9.5	SEC23B, LBR, CEACAM1, CEL, TGFB1, OXT
7	adipose tissue phenotype	MP:0005375	9.5	XDH, CEL, LBR, ARNTL, IL18, IL1R1
8	integument phenotype	MP:0010771	9.4	CSN1S1, F2, HSD3B7, ABCC3, HBB, TLR4
9	hematopoietic system phenotype	MP:0005397	9.2	FUT4, JAG1, ARNTL, MADCAM1, CCL25, AKR1A1
10	reproductive system phenotype	MP:0005389	9.2	PROP1, IL10, GUSB, KHK, AKR1A1, CCL2
11	vision/eye phenotype	MP:0005391	9.1	TLR4, IL10, GSR, TTR, ARNTL, GGT1
12	muscle phenotype	MP:0005369	8.6	IL18, IL10, TLR4, SRF, REN, BTD
13	behavior/neurological phenotype	MP:0005386	8.5	CCL2, F5, GHR, HMOX1, HMOX2, HLA-DQB1
14	nervous system phenotype	MP:0003631	8.2	ITGAM, ABCB7, SCT, TGFB1, THBD, HMOX2
15	growth/size phenotype	MP:0005378	8.1	ALPP, NTS, SRF, NR1I3, GH1, ABCB7
16	immune system phenotype	MP:0005387	7.8	GGT1, IL6, IL2, ARNTL, ASGR2, ITGAX
17	cellular phenotype	MP:0005384	7.6	ITGAM, SELL, UCP2, LBR, XDH, CEACAM1
18	cardiovascular system phenotype	MP:0005385	7.0	TNF, HLA-DQB1, HMOX2, HMOX1, GHR, F2
19	homeostasis/metabolism phenotype	MP:0005376	INF	ADAMTS13, SLC25A13, , SLC17A5, SLPI, NPPA
20	liver/biliary system phenotype	MP:0005370	INF	SLC25A13, ABCC3, ABCB7, ABCB11, NR1I3, GHR
21	mortality/aging	MP:0010768	INF	IL2RA, IL25, IL1R1, IL1B, ARNTL, GUSB

Articles related to jaundice:

(show top 50)    (show all 161)

id	Title	Authors	Year	Affiliating Genes
1	Gilbert-Meulengracht's syndrome and pharmacogenetics: is jaundice just the tip of the iceberg? (20070246)	Strassburg C.P.	2010	UGT1A1
2	Persistent jaundice in an infant with homozygous beta thalassemia due to co-inherited Crigler-Najjar syndrome. (19953640)	Aggarwal V.... Fabiano C.	2010	UGT1A1
3	A polymorphism near IL28B is associated with spontane ous clearance of acute hepatitis C virus and jaundice. (20637200)	Tillmann H.L.... Nattermann J.	2010	IL28B
4	Glucose-6-phosphate dehydrogenase and red cell pyruva te kinase deficiency in neonatal jaundice cases in egypt. (20426517)	Abdel Fattah M.... Kamal S.	2010	G6PD
5	A polymorphic mutation, c.-3279T>G, in the UGT1A1 promoter is a risk factor for neonatal jaundice in the Malay population. (20057336)	Yusoff S.... Van Rostenberghe H.	2010	UGT1A1
6	Decreased expression of intestinal chemokine TECK/CCL25 in experimental obstructive jaundice and its reversal following internal biliary drainage. (18592157)	Matsumoto T.... Ku Y.	2008	CCL20, CCL25
7	Effect of preoperative biliary drainage on liver function changes in patients with malignant obstructive jaundice in the low bile duct before and after pancreaticoduodenectomy (18184470)	Chen D.... Huang J.F.	2008	ALPP
8	Analysis of tear enzymes in the diagnosis of obstruc tive jaundice associated with subhepatic cholestasis (19143075)	Terekhina N.A.... Soldatenko N.V.	2008	GGT1
9	The frequency of UDP-glucuronosyltransferase 1A1 promoter region (TA)7 polymorphism in newborns and it's relation with jaundice. (17166930)	Muslu N.... Atik U.	2007	UGT1A1
10	(TA)n UGT 1A1 promoter polymorphism: a crucial factor in the pathophysiology of jaundice in G-6-PD deficient neonates. (17426648)	Kaplan M.... Stevenson D.K.	2007	G6PD, UGT1A1, UGT1A
11	The significance of serum hepatocyte growth factor levels in planning follow-up of postoperative jaundice-free patients with biliary atresia. (17011264)	Uchida K.... Kusunoki M.	2006	IL6, IL1RN
12	Red cell pyruvate kinase deficiency in neonatal jaundice cases in India. (17127778)	Kedar P.S.... Mohanty D.	2006	G6PD
13	Role of genetic factors in occurrence of neonatal jaundice in Guangxi region (16255851)	Fu W.P.... Liu Y.	2005	G6PD, SLCO1B1, UGT1A1
14	The role of UGT1A1*28 mutation in jaundiced infants with hypertrophic pyloric stenosis. (16257926)	Hua L.... Nowicki M.J.	2005	UGT1A1
15	Effects of recombinant human growth hormone on intestinal translocation of bacteria and endotoxin in rats with obstructive jaundice. (16109534)	Yang Z.W.... Cong Y.P.	2005	GH1
16	Dual hereditary jaundice: simultaneous occurrence of mutations causing Gilbert's and Dubin-Johnson syndrome. (16012956)	Cebecauerova D.... Jirsa M.	2005	UGT1A1
17	Contrasting liver function test patterns in obstructive jaundice due to biliary strictures [corrected] and stones. (15625352)	Hayat J.O.... Gorard D.A.	2005	ALPP, SLC17A5
18	An update on the prevalence of glucose-6-phosphate dehydrogenase deficiency and neonatal jaundice in Tehran neonates. (14972648)	Abolghasemi H.... Amid A.	2004	G6PD
19	The effect of neonatal jaundice on biotinidase activity. (12706308)	Schulpis K.H.... Costalos C.	2003	BTD
20	Type C-chronic hepatitis patients who had autoimmune phenomenon and developed jaundice during interferon therapy. (12768394)	Sezaki H.... Kumada H.	2003	IFNA1
21	Interest in the study of genetic variants of the promoter region of the UGT1A1 gene in neonatal jaundice (11827650)	Seco M.L.... Baiget M.	2002	UGT1A1
22	Obstructive jaundice results in increased liver expression of uncoupling protein 2 and intact skeletal muscle glucose metabolism in the rat. (11843026)	Isaksson B.... Permert J.	2002	UCP2
23	Factors predicting nutritional derangements in patients with obstructive jaundice: multivariate analysis. (11344390)	Padillo F.J.... Pera-Madrazo C.	2001	CCK
24	Clinical and experimental study of shuangcao tuihuang granule-1 in treating severe jaundice of acute icterohepatitis (12575547)	Lian Y.X.... Wu W.F.	2001	SLC17A5
25	Clinical study on the changes of growth hormone/insulin-like growth factor-I axis in patient with obstructive jaundice (11702667)	An Y.... Liu B.	2001	GHR, TTR, BLVRB
26	Glucose-6-phosphate dehydrogenase et neonatal jaundice (11317924)	Badens C.... Lena-Russo D.	2001	G6PD
27	Forced expression of murine IL-17E induces growth retardation, jaundice, a Th2-biased response, and multiorgan inflammation in mice. (11714825)	Pan G.... Gurney A.L.	2001	IL25
28	Infantile cholestatic jaundice associated with adult-onset type II citrullinemia. (11343052)	Tazawa Y.... Saheki T.	2001	SLC25A13
29	Gilbert's syndrome and jaundice in glucose-6-phosphate dehydrogenase deficient neonates. (10091404)	Iolascon A.... del Giudice E.M.	1999	G6PD
30	Serum endothelin-1 and hepatocyte growth factor levels in patients with obstructive jaundice. (10430302)	Higaki I.... Kinoshita H.	1999	HGF
31	The preliminary study on prevention and treatment of neonatal jaundice (9596945)	Xia Z.... Li Y.	1997	HMOX1, HMOX2
32	Plasma glutathione peroxidase activity and selenium levels of newborns with jaundice. (9363323)	Aydin A.... Isimer A.	1997	GPX3
33	Therapeutic effect of secretin in patients with jaundice; double-blind placebo-controlled multicentric trial. (8726832)	Fukumoto Y.... Shirasawa H.	1996	SCT
34	New concepts in bilirubin and jaundice: report of the Third International Bilirubin Workshop, April 6-8, 1995, Trieste, Italy. (8903413)	Tiribelli C.... Ostrow J.D.	1996	HMOX1
35	The negative heritability of neonatal jaundice. (8835092)	Haldane J.B.	1996	RHD
36	Neonatal jaundice in Qatif: The role of glucose-6-phosphate dehydrogenase deficiency in the etiology among outpatient cases. (17589001)	Al-Dabbous I.A.... Al-Khater N.S.	1995	G6PD
37	Enzyme deficiencies in neonates with jaundice. (8710395)	Casado A.... De La Torre R.	1995	G6PD
38	Hemolytic jaundice due to G6PD deficiency causing kernicterus in a female newborn. (7597488)	Washington E.C.... Holden K.	1995	G6PD
39	Glucose-6-phosphate dehydrogenase deficiency in the newborn: its prevalence and relation to neonatal jaundice. (8629093)	Tanphaichitr V.S.... Suvatte V.	1995	G6PD
40	Effects of cimetidine on IL-2 and T suppressor cell f unction in rats with obstructive jaundice. (7966522)	Ding X.Z.... Yang J.	1994	IL2
41	Do drugs in pregnancy modify neonatal jaundice? (8368029)	Meisel P.... Meisel M.	1993	OXT
42	Jaundice: clinical practice in 88,000 liveborn infants. (1445122)	Guaran R.L.... Watkins A.M.	1992	G6PD
43	Alpha-1-antitrypsin deficiency in babies with prolonged jaundice. (1304630)	Zakiah I.... Zawiah A.	1992	G6PD
44	Clinical value of serum tumour markers CEA, CA 50 and CA 242 in the distinction between malignant versus benign diseases causing jaundice and cholestasis; results from a prospective study. (1332581)	Pasanen P.A.... Alhava E.	1992	CEACAM3
45	Screening for glucose-6-phosphate dehydrogenase deficiency can prevent severe neonatal jaundice. (1283668)	Mallouh A.A.... Hamdan J.A.	1992	G6PD
46	Changes in plasma high density lipoprotein cholesterol and phospholipid in acute viral hepatitis and cholestatic jaundice. (1995758)	Ahaneku J.E.... Taylor G.O.	1991	ALPP
47	Intestinal origin alkaline phosphatase activity in plasma for differential diagnosis of jaundice. (1960213)	Kuwana T.... Rosalki S.B.	1991	ALPP
48	Role of genetic variability in neonatal jaundice. A prospective study on full-term, blood group-compatible infants. (1765134)	Lucarini N.... Bottini E.	1991	PGM1
49	Neonatal jaundice among Nigerian preterm infants. (2083201)	Owa J.A.... Dawodu A.H.	1990	G6PD
50	Plasma retinol transport system and taste acuity in patients with obstructive jaundice. (2347474)	Imamine T.... Muto Y.	1990	TTR

Genes related to jaundice according to GeneCards:

(show top 50)    (show all 132)

id	Symbol	Description	Score	GeneCards Section Context
1	G6PD	glucose-6-phosphate dehydrogenase	11.1	Publications, Summaries
2	CIRH1A	cirrhosis, autosomal recessive 1A (cirhin)	11.1	Summaries
3	RHD	Rh blood group, D antigen	11.0	Publications
4	GGT1	gamma-glutamyltransferase 1	11.0	Publications
5	ALPP	alkaline phosphatase, placental	11.0	Publications
6	HMOX1	heme oxygenase (decycling) 1	11.0	Publications
7	UGT1A1	UDP glucuronosyltransferase 1 family, polypeptide A1	11.0	Publications
8	SRF	serum response factor (c-fos serum response element-binding transcription factor)	11.0	Publications
9	AKR1A1	aldo-keto reductase family 1, member A1 (aldehyde reductase)	11.0	Publications
10	PSG2	pregnancy specific beta-1-glycoprotein 2	11.0	Publications
11	NR1I3	nuclear receptor subfamily 1, group I, member 3	11.0
12	SLCO1B1	solute carrier organic anion transporter family, member 1B1	11.0	Publications
13	CCK	cholecystokinin	11.0	Publications
14	GPT	glutamic-pyruvate transaminase (alanine aminotransferase)	11.0	Publications
15	OXT	oxytocin, prepropeptide	11.0	Publications
16	TTR	transthyretin	11.0	Publications
17	SLC17A5	solute carrier family 17 (anion/sugar transporter), member 5	11.0	Publications
18	ALB	albumin	11.0	Publications
19	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications
20	TNF	tumor necrosis factor	11.0	Publications
21	IGKV1-8	immunoglobulin kappa variable 1-8	11.0
22	HSD3B7	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7	11.0
23	KHK	ketohexokinase (fructokinase)	11.0	Publications
24	KRT76	keratin 76	11.0	Publications
25	UGT1A4	UDP glucuronosyltransferase 1 family, polypeptide A4	11.0	Publications
26	BPNT1	3'(2'), 5'-bisphosphate nucleotidase 1	11.0
27	CLDN4	claudin 4	11.0	Publications
28	FUT4	fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)	11.0	Publications
29	CCL27	chemokine (C-C motif) ligand 27	11.0	Publications
30	ASAH2	N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2	11.0	Publications
31	CCL25	chemokine (C-C motif) ligand 25	11.0	Publications
32	PKLR	pyruvate kinase, liver and RBC	11.0
33	HMOX2	heme oxygenase (decycling) 2	11.0	Publications
34	ITGAX	integrin, alpha X (complement component 3 receptor 4 subunit)	11.0	Publications
35	CEACAM1	carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)	11.0	Publications
36	TPI1	triosephosphate isomerase 1	11.0
37	AMACR	alpha-methylacyl-CoA racemase	11.0
38	PGM1	phosphoglucomutase 1	11.0	Publications
39	BTD	biotinidase	11.0	Publications
40	ABCC3	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	11.0	Publications
41	UCP2	uncoupling protein 2 (mitochondrial, proton carrier)	11.0	Publications
42	LBP	lipopolysaccharide binding protein	11.0	Publications
43	BLVRB	biliverdin reductase B (flavin reductase (NADPH))	11.0	Publications
44	CCL20	chemokine (C-C motif) ligand 20	11.0	Publications
45	OSM	oncostatin M	11.0	Publications
46	SCT	secretin	11.0	Publications
47	NTS	neurotensin	11.0	Publications
48	HP	haptoglobin	11.0	Publications
49	SLPI	secretory leukocyte peptidase inhibitor	11.0	Publications
50	ACP1	acid phosphatase 1, soluble	11.0

Pathways related to jaundice according to GeneDecks:

(show top 50)    (show all 119)

id	Pathway	Score	Top Affiliating Genes
1	Bacterial infections in CF airways41	10.8	IL1R1, LBP
2	RAR-Gamma-RXR-Alpha Degradation36	10.7	CCL20, CCL27, CCL25, IL2, OSM
3	Regulation of eIF4 and p70S6K36	10.5	ITGAL, ITGAM, ITGAX, IL18, IL2, IL6
4	NFAT Signaling and Lymphocyte Interactions36	10.5	IL2, CCL27, CCL2, CCL20, CCL25
5	PGC1Alpha Pathway36	10.5	IL1B, CCL25, CCL20, IL2, IL1R1, IL18
6	Akt Signaling36	10.5	ITGAX, ITGAM, IL10, IL18, CCL25, IL2
7	Endothelin-1 Signaling Pathway36	10.5	CCL25, OSM, CCL20, CCL27, IL2, IL10
8	IL-10 Pathway36	10.4	HMOX1, TLR4, TNF, IL10, CD14, IL1B
9	PEDF Induced Signaling36	10.4	CCL25, SRF, OSM, IL18, HGF, CCL20
10	ERK Signaling36	10.3	IL6, IL2, IL1B, ITGAM, IL10, ITGAL
11	IL-6 Pathway36	10.3	HGF, IL10, IL8, CCL27, CCL2, CCL20
12	all-trans-Retinoic Acid Signaling in Brain36	10.3	TNF, OSM, HGF, IL18, CCL2, CCL25
13	MIF Mediated Glucocorticoid Regulation36	10.3	CCL2, HGF, TLR4, CCL25, CCL20, CD14
14	MIF Regulation of Innate Immune Cells36	10.3	CD14, OSM, HGF, TLR4, TNF, CCL25
15	STAT3 Pathway36	10.3	CCL27, IL8, IL6, IL2RA, IL2, IL1R1
16	PAK Pathway36	10.1	IGF1, GH1, TNF, TGFB1, IL6, OSM
17	Irinotecan Pathway, Pharmacodynamics34	10.1	UGT1A1, UGT1A8, UGT1A6, UGT1A4, UGT1A3, UGT1A10
18	TGF-Beta Pathway36	10.0	CCL20, CCL25, IGF1, GH1, HGF, TGFB1
19	MAPK Family Pathway36	10.0	IL6, HGF, TGFB1, TNF, GH1, IGF1
20	Glucocorticoid Receptor Signaling36	10.0	IL10, CCL25, IL18, CCL20, IL8, CCL2
21	Tec Kinases Signaling36	10.0	CCL20, CCL2, CCL27, IL8, IL6, IL2RA
22	Molecular Mechanisms of Cancer36	10.0	HGF, IL2, IL1R1, ITGAX, ITGAM, ITGAL
23	Rho Family GTPases36	10.0	CCL27, IL18, CCL2, IL10, ITGAX, ITGAM
24	Antioxidant Action of Vitamin-C36	9.9	IL2RA, IL18, IGF1, GH1, IL10, HGF
25	p38 Signaling36	9.9	TNF, OSM, HGF, IGF1, TGFB1, CCL20
26	Malaria20	9.9	IL6, IL1B, IL10, IL18, ITGAL, TGFB1
27	Ascorbate and aldarate metabolism20	9.8	UGT1A4, UGT1A3, UGT1A10, UGT1A5, UGT1A6, UGT1A8
28	Other types of O-glycan biosynthesis20	9.8	UGT1A3, UGT1A9, UGT1A7, UGT1A10, UGT1A6, UGT1A5
29	Pentose and glucuronate interconversions20	9.8	GUSB, UGT1A8, UGT1A1, UGT1A7, UGT1A6, UGT1A5
30	Amoebiasis20	9.8	IL1R1, IL8, IL6, TLR4, TGFB1, IL1B
31	Graft-versus-host disease20	9.8	IL2, HLA-DQA1, HLA-DRB5
32	Starch and sucrose metabolism20	9.8	UGT1A9, GUSB, PGM1, UGT1A6, UGT1A5, UGT1A4
33	Drug metabolism - other enzymes20	9.7	UGT1A6, UGT1A9, UGT1A10, UGT1A7, UGT1A8, UGT1A5
34	Porphyrin and chlorophyll metabolism20	9.7	UGT1A8, UGT1A3, UGT1A10, UGT1A4, UGT1A5, UGT1A6
35	Metabolism of xenobiotics by cytochrome P45020	9.7	UGT1A1, UGT1A8, UGT1A9, GSTM1, UGT1A6, UGT1A10
36	Drug metabolism - cytochrome P45020	9.6	UGT1A10, GSTT1, UGT1A9, UGT1A4, UGT1A5, UGT1A6
37	Steroid hormone biosynthesis20	9.6	UGT1A9, UGT1A6, UGT1A4, UGT1A5, UGT1A8, UGT1A1
38	Cytokine Network36	9.6	IL8, IL6, IL2, IL18, IL10, IFNA1
39	Retinol metabolism20	9.4	UGT1A7, UGT1A5, UGT1A10, UGT1A8, UGT1A9, UGT1A1
40	Hematopoietic cell lineage20	9.4	IL1B, CD14, TNF, HLA-DRB5, HLA-DRB1, IL6
41	JAK-STAT Pathway36	9.1	TGFB1, HGF, IL2RA, IL2, IL1R1, GH1
42	Cytokine-cytokine receptor interaction20	9.1	IFNA1, IL10, IL18, OSM, TGFB1, TNF
43	Metabolic pathways20	8.9	BTD, BPNT1, XDH, CEL, FUT4, ASAH2
44	THC Differentiation Pathway36	8.7	TNF, IL10, IL18, IL2, IL2RA, HLA-DQA1
45	Intestinal immune network for IgA production20	8.7	HLA-DRB5, HLA-DQB1, HLA-DQA1, CCL25, CCL27, MADCAM1
46	Leishmaniasis20	8.6	IL10, IL1B, ITGAM, HLA-DQA1, HLA-DRB1, TLR4
47	Rheumatoid arthritis20	8.6	TGFB1, IL1B, IL18, ITGAL, IL6, IL8
48	Tuberculosis20	7.8	HLA-DQB1, HLA-DRB1, HLA-DRB5, TLR4, TGFB1, IL10
49	Influenza A20	7.5	IL6, IL1B, IL18, HLA-DRB5, HLA-DQB1, CCL2
50	Mycophenolic acid Pathway, Pharmacokinetics34	INF	SLCO1B1, ABCC2, , UGT1A9, UGT1A8, UGT1A7

Compounds related to jaundice according to GeneDecks:

(show top 50)    (show all 586)

id	Compound	Score	Top Affiliating Genes
1	cyclophosphamide32 34 9 9	13.9	ITGAL
2	n acetylcysteine32	10.5	CD79A, ITGAM, IL18, IL1R1, IL2RA, GPT
3	sb 20358032 42	11.5	ITGAM, IL1R1, IL6, IGF1, ALPP, GH1
4	vitamin b1232	10.5	CD79A, GUSB, CCL2, IGF1, F5, ALB
5	citrate32	10.4	CD79A, GUSB, AMACR, CAT, GLUD1, HP
6	pdtc32	10.4	XDH, ITGAX, IL18, IL6, IL8, CCL2
7	mycophenolic acid32 9 9	12.3	UGT1A10, UGT1A7, UGT1A8, IL2
8	verapamil32 34 9 18 9	14.3	REN, IL2RA, APP, GPT, AKR1A1, GH1
9	nifedipine32 9 9	12.1	REN, UGT1A, LBR, ALPP, GH1, HMOX1
10	pge132	10.0	SELL, LCAT, IL18, IL1RN, GPT, F5
11	mannitol32 9 9	12.0	SCT, XDH, GUSB, CAT, GLUD1, AKR1A1
12	atorvastatin32 34 9 18 9	13.8	SELL, LCAT, ITGAM, IL10, IL18, IL1RN
13	carbohydrates32	9.8	SELL, UCP2, FUT4, CD14, ASGR2, IL1RN
14	endotoxin32	9.8	SELL, BLVRB, LBP, CD14, ITGAL, ITGAM
15	acetaminophen32 34 9 18 9	13.7	UGT1A, UGT1A1, UGT1A4, UGT1A6, UGT1A7, UGT1A9
16	vitamin a32 9 18 9	12.7	LCAT, LAP3, GSR, GSTM1, APP, GPT
17	cellulose acetate32	9.7	CD79A, IL1R1, IL1RAPL2, IL1RN, ALB, ALPP
18	polysaccharide32	9.6	SELL, LBP, LAP3, CEACAM1, CEL, FUT4
19	methionine32	9.6	LCAT, LBR, LAP3, CD14, GSTT1, IL1R1
20	sodium dodecylsulfate32	9.5	LCAT, CD79A, IL18, IL1R1, IL1RN, APP
21	leukotriene b432 42 18	11.5	SELL, LAP3, ITGAL, ITGAM, ITGAX, GUSB
22	simvastatin32 34 42 9 18 9	14.5	SELL, LCAT, CEL, ITGAL, ITGAM, IL10
23	cuprophan32	9.4	SELL, LBR, CD14, ITGAL, ITGAM, IL1B
24	androsterone glucuronide32 18	10.3	UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6
25	alpha tocopherol32	9.3	LCAT, XDH, CEL, ITGAL, ITGAM, GSR
26	glutamate32	9.3	BLVRB, LCAT, LAP3, CD79A, ITGAL, GSR
27	pentoxifylline32 9 9	11.3	SELL, LBR, CD14, ITGAM, IL10, IL18
28	thyroxine32 18	10.3	REN, SCT, UGT1A, UGT1A1, UCP2, CEACAM3
29	aspirin32 34 18	11.2	SELL, UGT1A6, CD79A, ITGAL, ITGAM, GUSB
30	troglitazone32 42 9 9	12.2	UGT1A, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A6
31	uric acid32 18	10.2	XDH, GSR, IL1R1, GPT, GPX3, F5
32	vitamin d32	9.2	LBR, CD79A, CD14, ITGAM, GSTM1, IL10
33	cysteine32	9.1	BTD, SCT, LCAT, LBR, LAP3, XDH
34	h2o232	8.9	SELL, MUC16, UCP2, LBR, LAP3, XDH
35	rantes32	8.9	SELL, SCT, LBR, CD14, ITGAL, ITGAM
36	il-1232	8.9	IL10, IL18, IL1B, IL1R1, IL2, IL6
37	adenylate32	8.8	BLVRB, SCT, CEL, ITGAM, GSR, IL18
38	vitamin-e32	8.8	UCP2, LBR, CEL, GSR, GSTT1, IL1R1
39	epinephrine32 9 18 9	11.7	REN, SELL, SCT, UGT1A, LBR, CD79A
40	superoxide32 18	9.6	SELL, BLVRB, UCP2, LBP, LBR, XDH
41	actinomycin d32	8.5	UGT1A, LBP, ITGAL, IL1B, IL1R1, IL1RAPL2
42	glutamine32	8.4	SCT, UCP2, LCAT, CD14, ITGAM, IL18
43	chloroquine32 34 9 9	11.2	CEL, CD79A, ITGAL, ITGAM, GSR, IL10
44	creatinine32	8.0	REN, SELL, MUC16, LBP, LAP3, CEACAM3
45	testosterone32 9 18 9	10.9	BLVRB, SCT, UGT1A, UGT1A1, UGT1A10, UGT1A3
46	cholesterol32 9 18 9	10.7	REN, UGT1A1, UCP2, LCAT, LBP, LBR
47	lactate32	7.6	BTD, SELL, MUC16, UCP2, LAP3, XDH
48	alanine32	6.1	BTD, SELL, UGT1A1, UCP2, LCAT, LBP
49	methotrexate32 34 42 9 9	INF	CEACAM3, CD79A, GSR, GSTM1, IL10, IL18
50	ursodeoxycholic acid32 9 18 9	INF	SCT, LBR, CCK, GPT, IFNA1, F2

Cellular components related to jaundice according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	platelet alpha granule lumen	GO:031093	10.2	IGF1, HGF, APP, F5, ALB, TGFB1
2	cell surface	GO:009986	10.1	IL1R1, ADAMTS13, TGFB1, THBD, ELANE, ALPP
3	external side of plasma membrane	GO:009897	9.5	HLA-DRB1, SELL, CD79A, ITGAL, ITGAX, HLA-DRB5
4	extracellular region	GO:005576	9.0	HGF, SCT, IL2, IL6, IL8, APP
5	membrane	GO:016020	8.5	HLA-DRB1, ABCB11, ABCC3, SLC17A5, GALK1, GGT1
6	extracellular space	GO:005615	8.4	HGF, IL25, IL28B, IL6, IL8, CCL27
7	MHC class II protein complex	GO:042613	8.3	HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DRB5
8	plasma membrane	GO:005886	INF	ITGAX, CD79A, SELL, CLDN4, IL2RA, MUC16
9	integral to plasma membrane	GO:005887	INF	TNF, RHD, ABCB11, ABCC2, ABCC3, TLR4

Biological processes related to jaundice according to GeneDecks:

(show top 50)    (show all 52)

id	Name	GO ID	Score	Top Affiliating Genes
1	heme catabolic process	GO:042167	10.8	UGT1A1, HMOX1, BLVRA, BLVRB, HMOX2
2	positive regulation of chemokine production	GO:032722	10.8	IL18, IL6, TNF, TLR4, LBP
3	porphyrin-containing compound metabolic process	GO:006778	10.8	HMOX1, UGT1A1, BLVRB, HMOX2, BLVRA
4	positive regulation of smooth muscle cell proliferation	GO:048661	10.7	TNF, IGF1, HMOX1, ELANE, EDN1, IL6
5	regulation of sensory perception of pain	GO:051930	10.7	TLR4, CCK, IL10, OXT, EDN1
6	response to progesterone stimulus	GO:032570	10.7	CCL2, TGFB1, CLDN4, OXT, TLR4
7	positive regulation of interleukin-6 production	GO:032755	10.7	TLR4, LBP, IL1B, IL6, TNF
8	leukocyte migration	GO:050900	10.6	THBD, SELL, ITGAL, ELANE, F2, CCL25
9	response to activity	GO:014823	10.6	TLR4, TNF, CCL2, IL10, OXT
10	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	10.6	OSM, HGF, IL6, TLR4, GHR, GH1
11	lipopolysaccharide-mediated signaling pathway	GO:031663	10.6	LBP, IL18, TNF, CCL2, IL1B, TGFB1
12	negative regulation of growth of symbiont in host	GO:044130	10.6	LBP, IL10, TNF, ELANE
13	response to heat	GO:009408	10.6	CCL2, PKLR, OSM, CD14, SOD1, IL1B
14	positive regulation of interferon-gamma production	GO:032729	10.5	TNF, TLR4, IL2, IL1B, IL18
15	cellular response to organic cyclic compound	GO:071407	10.5	IL1B, TGFB1, TNF, CCL2, IL18
16	cellular response to lipopolysaccharide	GO:071222	10.5	IL8, TLR4, LBP, IL10, CD14, CCL2
17	positive regulation of tyrosine phosphorylation of Stat5 protein	GO:042523	10.4	GHR, GH1, IGF1, IL2
18	platelet degranulation	GO:002576	10.4	ALB, TGFB1, HGF, APP, TF, IGF1
19	positive regulation of MAP kinase activity	GO:043406	10.4	EDN1, TNF, TGFB1, GH1, ELANE
20	platelet activation	GO:030168	10.4	SRF, HGF, ADAMTS13, SOD1, TF, TGFB1
21	response to hypoxia	GO:001666	10.4	IL1B, TGFB1, TLR4, EDN1, PKLR, IL18
22	xenobiotic metabolic process	GO:006805	10.3	GGT1, UGT1A9, UGT1A6, UGT1A5, UGT1A4, UGT1A1
23	inflammatory response	GO:006954	10.3	CRP, CD14, ITGAL, IL10, IL18, IL1B
24	glutathione metabolic process	GO:006749	10.3	GPX3, SOD1, GSTT1, G6PD, GSR, GGT1
25	flavonoid glucuronidation	GO:052696	10.2	UGT1A8, UGT1A7, UGT1A3, UGT1A1, UGT1A9
26	flavone metabolic process	GO:051552	10.2	UGT1A7, UGT1A8, UGT1A1, UGT1A9, UGT1A10
27	xenobiotic glucuronidation	GO:052697	10.2	UGT1A1, UGT1A9, UGT1A8, UGT1A7, UGT1A3
28	anti-apoptosis	GO:006916	10.2	HMOX1, HGF, SOD1, TNF, IGF1, CCL2
29	cell surface receptor signaling pathway	GO:007166	10.2	F2, CCL2, ASGR2, IL1R1, EDN1, CCL25
30	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	10.2	IGF1, F2, GH1, HGF, CAT
31	retinoic acid metabolic process	GO:042573	10.2	UGT1A9, UGT1A8, UGT1A7, UGT1A3, UGT1A1
32	chronic inflammatory response to antigenic stimulus	GO:002439	10.2	IL1B, IL1RN
33	positive regulation of interleukin-8 production	GO:032757	10.2	TLR4, IL1B, IL18, LBP
34	positive regulation of nitric oxide biosynthetic process	GO:045429	10.2	HBB, TNF, IL1B, EDN1, TLR4
35	negative regulation of fatty acid metabolic process	GO:045922	10.1	UGT1A8, UGT1A7, UGT1A9
36	response to glucocorticoid stimulus	GO:051384	10.1	IL1B, IL1RN, IL6, GHR, LCAT, CCL2
37	female pregnancy	GO:007565	10.1	TGFB1, IL1RN, GPX3, THBD, CLDN4, OXT
38	acute-phase response	GO:006953	10.1	F2, IL6, LBP, IL1RN, CRP
39	metabolic process	GO:008152	10.1	UGT1A3, UGT1A9, UGT1A6, UGT1A5, UGT1A10
40	T-helper 1 type immune response	GO:042088	9.9	TLR4, HLA-DRB5, HLA-DRB1, IL18
41	blood coagulation	GO:007596	9.8	F5, F2, HGF, HBB, TGFB1, ALB
42	response to drug	GO:042493	9.5	GPX3, REN, SOD1, TGFB1, EDN1, TNF
43	positive regulation of transcription from RNA polymerase II promoter	GO:045944	9.3	TNF, SRF, PROP1, JAG1, ARNTL, IL1B
44	immunoglobulin production involved in immunoglobulin mediated immune response	GO:002381	9.0	HLA-DQB1, HLA-DRB5, HLA-DRB1
45	immune response	GO:006955	8.0	IL1RN, IL2, IL2RA, IL8, MADCAM1, CCL27
46	small molecule metabolic process	GO:044281	INF	UCP2, GUSB, GSR, GSTM1, GPT, AMACR
47	bile acid and bile salt transport	GO:015721	INF	ATP8B1, ABCB11, ABCC3, , SLCO1B1, ALB
48	organic anion transport	GO:015711	INF	ABCC3, ABCC2, , SLCO1B1
49	transmembrane transport	GO:055085	INF	ABCC3, TF, SLC35A2, SLC17A5, , SLCO1B1
50	bile acid metabolic process	GO:008206	INF	AMACR, ALB, HSD3B7, ABCB11, ABCC3,

Molecular functions related to jaundice according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	hormone activity	GO:005179	10.2	CCL25, CCK, IGF1, GH1, EDN1, TTR
2	growth factor activity	GO:008083	9.9	IL10, HGF, TGFB1, JAG1, IL1B, IL2
3	retinoic acid binding	GO:001972	9.6	UGT1A1, UGT1A8, UGT1A10, UGT1A3, UGT1A4, UGT1A6
4	cytokine activity	GO:005125	9.6	IL18, IL1B, IL25, IL28B, IL6, TNF
5	glucuronosyltransferase activity	GO:015020	9.6	UGT1A1, UGT1A7, UGT1A8, UGT1A6, UGT1A5, UGT1A4
6	enzyme binding	GO:019899	9.3	SLPI, TGFB1, HMOX1, CAT, UGT1A9, UGT1A8
7	protein heterodimerization activity	GO:046982	8.7	ITGAL, ARNTL, HNF1B, TGFB1, UGT1A9, UGT1A8
8	protein homodimerization activity	GO:042803	8.6	CRP, SRF, HMOX1, UGT1A6, CAT, G6PD