MCID: JBS001
MIFTS: 47

Job's Syndrome malady

Immune diseases category

Summaries for Job's Syndrome

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46OMIM, 32MalaCards
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MalaCards: Job's Syndrome, also known as hyperimmunoglobulin e syndrome, is related to hyper ige syndrome and diarrhea. An important gene associated with Job's Syndrome is CARD9 (caspase recruitment domain family, member 9), and among its related pathways are Immune response IL-12 signaling pathway and IL-10 Pathway. The compounds bucillamine and gamma globulin have been mentioned in the context of this disorder. Affiliated tissues include colon, lung and eye, and related mouse phenotypes are homeostasis/metabolism and cellular.

Description from OMIM:46 147060

Aliases & Classifications for Job's Syndrome

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Sources:
8Disease Ontology, 60UMLS, 22GTR, 34MeSH, 39NCIt, 46OMIM, 56SNOMED-CT, 25ICD10
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Related Diseases for Job's Syndrome

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17GeneCards, 18GeneDecks
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Diseases related to Job's Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 109)
idRelated DiseaseScoreTop Affiliating Genes
1hyper ige syndrome30.5IFNG, STAT3, IGHE, IGES
2diarrhea30.2CD79A
3bullous pemphigoid30.2CD79A, IGHE
4atopic dermatitis30.2IGES, IGHE, IFNG
5dermatitis30.2IFNG, IGHE, IGES, CD79A
6hyperimmunoglobulin syndrome10.9
7necrotizing fasciitis10.3
8fasciitis10.3
9syndromic diarrhea10.1
10pleuropneumonia10.1
11molluscum contagiosum10.1
12pseudotumor cerebri10.1
13chronic granulomatous disease10.1
14nocardiosis10.1
15neonatal diabetes mellitus10.1
16osteochondritis dissecans10.1
17autosomal recessive disease10.1
18calcinosis10.1
19dermatomyositis10.1
20diabetes mellitus10.1
21endocarditis10.1
22histoplasmosis10.1
23autosomal dominant hyper ige syndrome10.1
24autosomal recessive hyper ige syndrome10.1
25hyper-ige recurrent infection syndrome, autosomal recessive10.1
26bronchiolitis10.0IGHE
27strongyloidiasis10.0IGHE
28urticaria10.0IGHE
29intrinsic asthma10.0IGHE
30eosinophilic gastroenteritis10.0IGHE
31tyrosine kinase 2 deficiency10.0TYK2
32measles10.0CD79A
33toxoplasmosis10.0CD79A
34mumps10.0CD79A
35pulmonary eosinophilia10.0IGHE
36omenn syndrome10.0IGHE
37pertussis10.0CD79A
38lupus erythematosus10.0CD79A
39autoimmune hemolytic anemia10.0CD79A
40tonsillitis10.0CD79A
41gastritis10.0CD79A
42rubella10.0CD79A
43glomerulonephritis10.0CD79A
44mycosis fungoides10.0STAT3
45bronchitis10.0CD79A
46gastroenteritis10.0CD79A
47diphtheria10.0CD79A
48hyperthyroidism10.0IGES
49neutropenia10.0STAT3
50pemphigus10.0CD79A

Graphical network of the top 20 diseases related to Job's Syndrome:



Diseases related to job's syndrome

Clinical Features for Job's Syndrome

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46OMIM
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Clinical features from OMIM:

147060

Drugs & Therapeutics for Job's Syndrome

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Job's Syndrome

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Sources:
22GTR
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Genetic tests related to Job's Syndrome:

id Genetic test Affiliating Genes
1 Hyperimmunoglobulin E Syndrome22

Anatomical Context for Job's Syndrome

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32MalaCards
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MalaCards organs/tissues related to Job's Syndrome:

32
Colon, Lung, Eye, T cells

Animal Models for Job's Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Job's Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.6IFNG, IRAK4, STAT3, IGHE, TYK2, CD79A
2MP:00053846.9CLEC6A, CD79A, TYK2, DOCK8, STAT3, IRAK4
3MP:00053976.5TYK2, IGHE, DOCK8, STAT3, IRAK4, IFNG
4MP:00053876.3CARD9, IFNG, IRAK4, STAT3, DOCK8, IGHE

Publications for Job's Syndrome

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50PubMed
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Articles related to Job's Syndrome:

(show top 50)    (show all 75)
idTitleAuthorsYear
1
Safety of major abdominal surgical procedures in patients with hyperimmunoglobulinemia E (Job's syndrome): a changing paradigm? (23188219)
2013
2
Job's syndrome with an atypical presentation. (24392534)
2013
3
Rectal histoplasmosis in Job's syndrome. (23151895)
2013
4
Fungal infection of gingiva in a patient with hyperimmunoglobulin-E (Job's) syndrome. (23055595)
2012
5
Acupuncture for symptom management in patients with hyper-IgE (Job's) syndrome. (21208131)
2011
6
Recurrent giant chalazia in hyperimmunoglobulin E (Job's) syndrome. (18528638)
2009
7
Hyper IgE (Job's) syndrome: a primary immune deficiency with oral manifestations. (19036057)
2009
8
Methicillin-resistant Staphylococcus aureus (MRSA) mitral valve acute bacterial endocarditis (ABE) in a patient with Job's syndrome (hyperimmunoglobulin E syndrome) successfully treated with linezolid and high-dose daptomycin. (18206530)
2008
9
Hyperimmunoglobulin E syndrome (Job's syndrome). (19284090)
2008
10
STAT3 mutation in the original patient with Job's syndrome. (17942886)
2007
11
Peripheral T-cell lymphoma and Job's syndrome: a rare association. (16645241)
2006
12
Disseminated pulmonary candidiasis complicating hyperimmunoglobulin E (Job's) syndrome. (14712133)
2004
13
Recurrent Staphylococcus aureus chalazia in hyperimmunoglobulinemia E (Job's) syndrome. (15629308)
2004
14
Importance of life-long continuous antimicrobial prophylaxis to prevent infections in patients with Job's syndrome. (15325512)
2004
15
Job's syndrome. (15250440)
2004
16
Job's syndrome--a case report. (14761145)
2003
17
Job's syndrome. A case report. (12700555)
2003
18
28-Year-Old Patient with Elevated Serum IgE Levels and Multiple Refractory Epidural and Paravertebral Abscesses. Clinical manifestation of a Job's Syndrome?]. (14551710)
2003
19
Generalized lymphadenopathy caused by Trichosporon asahii in a patient with Job's syndrome. (11862981)
2002
20
Meconium thorax: A case of Bochdalek hernia and cecal perforation in a neonate with Job's syndrome. (11912536)
2002
21
Clinical pathology case: hyperimmunoglobulin E syndrome (Job's syndrome). (11486352)
2001
22
Molluscum contagiosum and Job's syndrome. (11832646)
2001
23
Regulation of immunoglobulin production in hyper-IgE (Job's) syndrome. (9949327)
1999
24
Oral zinc in Job's syndrome. (20921729)
1998
25
Pneumatocele complicated by fungal lung abscess in Job's syndrome. Successful lobectomy with the aid of videothoracoscopy. (9264169)
1997
26
Job's syndrome associated with HIV infection improved with immune globulin therapy. (8902088)
1996
27
A case of Job's syndrome]. (8675115)
1996
28
An adult patient with hyperimmunoglobulemia E (Job's) syndrome, end-stage renal disease and repeated episodes of peritonitis. (8026117)
1994
29
Pneumatocele complicating hyperimmunoglobulin E syndrome (Job's Syndrome). (1449312)
1992
30
Recurrent colonic histoplasmosis after standard therapy with amphotericin B in a patient with Job's syndrome. (1986542)
1991
31
Job's syndrome (granulomatous disease variant). (2234765)
1990
32
Spinal anaesthesia in a child with Job's syndrome, pneumatoceles and empyema. (2356933)
1990
33
Job's syndrome: a rare cause of recurrent lung abscess in childhood. (2241394)
1990
34
Cryptococcosis of the colon resembling Crohn's disease in a patient with the hyperimmunoglobulinemia E-recurrent infection (Job's) syndrome. (3338649)
1988
35
Neonatal Job's syndrome featuring a vesicular eruption. (3412996)
1988
36
Evolution of the hyperimmunoglobulin E and recurrent infection (HIE, JOB's) syndrome in a young girl. (3680819)
1987
37
Elevated urinary histamine in the hyperimmunoglobulin E and recurrent infection (Job's) syndrome: association with eczematoid dermatitis and not with infection. (3819231)
1987
38
Immunoglobulins in the hyperimmunoglobulin E and recurrent infection (Job's) syndrome. Deficiency of anti-Staphylococcus aureus immunoglobulin A. (3871199)
1985
39
Esophageal cryptococcosis in a patient with the hyperimmunoglobulin E-recurrent infection (Job's) syndrome. (6373479)
1984
40
Deficiency in C3b receptors on neutrophils of patients with chronic granulomatous disease and hyperimmunoglobulin-E recurrent infection (Job's) syndrome. (6240460)
1984
41
Levamisole is inferior to placebo in the hyperimmunoglobulin E recurrent-infection (Job's) syndrome. (6806658)
1982
42
Job's syndrome. (7401839)
1980
43
Atopic dermatitis and impaired neutrophil chemotaxis in Job's syndrome. (869552)
1977
44
Defect in neutrophil granulocyte chemotaxis in Job's syndrome of recurrent "cold" staphylococcal abscesses. (4137601)
1974
45
Job's syndrome and chronic granulomatous disease. (5410629)
1970
46
Job's syndrome and chronic granulomatous disease. (5410153)
1970
47
Job's syndrome. (4903095)
1970
48
Job's syndrome--a variant of chronic granulomatous disease. Report of a case. (5815897)
1969
49
Leucocytes in Job's syndrome. (4180157)
1969
50
Job's Syndrome. Recurrent, "cold", staphylococcal abscesses. (4161105)
1966

Genetic Variations for Job's Syndrome

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Expression for genes affiliated with Job's Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Job's Syndrome

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Pathways for genes affiliated with Job's Syndrome

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Sources:
12EMD Millipore, 51QIAGEN, 37NCBI BioSystems Database, 53Reactome, 29KEGG, 4Cell Signaling Technology, 52R&D Systems
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Pathways related to Job's Syndrome according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1TYK2
29.7TYK2, STAT3
39.7TYK2, STAT3
4
Immune response Oncostatin M signaling via JAK-Stat in human cells
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9.7TYK2, STAT3
59.7TYK2, STAT3
69.6IFNG, STAT3
7
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9.4TYK2, STAT3, IRAK4
89.4CARD9, IFNG, IRAK4
9
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9.3STAT3, IRAK4, IFNG
109.3TYK2, STAT3, IFNG
119.3TYK2, STAT3, IFNG
12
Development Thrombopoetin signaling via JAK-STAT pathway
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9.3IFNG, STAT3, TYK2
13
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9.3IFNG, STAT3, TYK2
14
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9.3IFNG, STAT3, TYK2
15
Development PDGF signaling via STATs and NF-kB
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9.3IFNG, STAT3, TYK2
16
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9.0CLEC6A, IRAK4, CARD9
17
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8.9TYK2, STAT3, IRAK4, IFNG
18
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8.9TYK2, STAT3, IRAK4, IFNG
19
Hide members
8.9TYK2, STAT3, IRAK4, IFNG
20
Hide members
8.9IFNG, IRAK4, STAT3, CD79A
21
Hide members
7.6CD79A, TYK2, IGHE, STAT3, IRAK4, IFNG

Compounds for genes affiliated with Job's Syndrome

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44Novoseek, 49PharmGKB, 11DrugBank, 2BitterDB, 59Tocris Bioscience, 28IUPHAR, 24HMDB
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Compounds related to Job's Syndrome according to GeneCards/GeneDecks:

(show all 30)
idCompoundScoreTop Affiliating Genes
1bucillamine4410.0CD79A, IFNG
2gamma globulin4410.0IFNG, CD79A
3tuberculin4410.0CD79A, IFNG
4adalimumab44 49 1111.9IFNG, CD79A
5isoniazid49 44 1111.9CD79A, IFNG
6unicap449.8CD79A, IGHE
7okt3449.8CD79A, IFNG
8sodium cromoglycate449.8IGHE, CD79A
9con a449.8IFNG, CD79A
10enterotoxin449.8CD79A, IGES
11praziquantel44 1110.8IGHE, CD79A
12penicillin449.8CD79A, IGHE
13gliadin449.8CD79A, IGHE
14silicone449.7IGHE, CD79A
15parthenolide44 210.7IFNG, STAT3
16ifn-alpha449.6IFNG, STAT3, TYK2
17budesonide44 49 1111.5IFNG, IGHE
18ivig449.4CD79A, IGHE, IFNG
19fluticasone propionate44 49 59 1112.4IGHE, IFNG
20prednisolone44 28 1111.4CD79A, IGHE, IFNG
21methacholine44 1110.3IGHE, IGES, CD79A
22salbutamol44 49 28 11 2413.2CD79A, IGHE
23n acetylcysteine449.1STAT3, IGHE, CD79A
24allergens448.9CD79A, IGES, IGHE, IFNG
25histamine44 28 2410.9IFNG, IGHE, IGES, CD79A
26dexamethasone44 49 28 1111.8IFNG, STAT3, IGHE, CD79A
27vegf448.8CD79A, IGHE, STAT3, IFNG
28retinoic acid44 249.6IFNG, STAT3, IGHE, TYK2, CD79A
29arginine448.5CD79A, IGHE, STAT3, IFNG
30cyclosporin a44 28 5910.5IFNG, STAT3, IGHE, IGES, CD79A

GO Terms for genes affiliated with Job's Syndrome

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16Gene Ontology
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Biological processes related to Job's Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of tumor necrosis factor productionGO:0327609.4IFNG, CARD9
2response to drugGO:0424939.3STAT3, IFNG, CARD9
3cytokine-mediated signaling pathwayGO:0192218.9TYK2, STAT3, IRAK4, IFNG
4innate immune responseGO:0450878.3CARD9, IRAK4, IGHE, CLEC6A

Products for genes affiliated with Job's Syndrome

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Sources for Job's Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet