MCID: JBS001
MIFTS: 47

Job's Syndrome malady

Immune diseases category

Summaries for Job's Syndrome

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46OMIM, 32MalaCards
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MalaCards: Job's Syndrome, also known as hyperimmunoglobulin e syndrome, is related to hyper ige syndrome and diarrhea. An important gene associated with Job's Syndrome is CARD9 (caspase recruitment domain family, member 9), and among its related pathways are Immune response IL-12 signaling pathway and IL-10 Pathway. The compounds bucillamine and gamma globulin have been mentioned in the context of this disorder. Affiliated tissues include colon, lung and eye, and related mouse phenotypes are homeostasis/metabolism and cellular.

Description from OMIM:46 147060

Aliases & Classifications for Job's Syndrome

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Sources:
8Disease Ontology, 60UMLS, 22GTR, 34MeSH, 39NCIt, 46OMIM, 56SNOMED-CT, 25ICD10
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Related Diseases for Job's Syndrome

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17GeneCards, 18GeneDecks
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Diseases related to Job's Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 109)
idRelated DiseaseScoreTop Affiliating Genes
1hyper ige syndrome30.5IFNG, STAT3, IGHE, IGES
2diarrhea30.2CD79A
3bullous pemphigoid30.2CD79A, IGHE
4atopic dermatitis30.2IGES, IGHE, IFNG
5dermatitis30.2IFNG, IGHE, IGES, CD79A
6hyperimmunoglobulin syndrome10.9
7necrotizing fasciitis10.3
8fasciitis10.3
9syndromic diarrhea10.1
10pleuropneumonia10.1
11molluscum contagiosum10.1
12pseudotumor cerebri10.1
13chronic granulomatous disease10.1
14nocardiosis10.1
15neonatal diabetes mellitus10.1
16osteochondritis dissecans10.1
17autosomal recessive disease10.1
18calcinosis10.1
19dermatomyositis10.1
20diabetes mellitus10.1
21endocarditis10.1
22histoplasmosis10.1
23autosomal dominant hyper ige syndrome10.1
24autosomal recessive hyper ige syndrome10.1
25hyper-ige recurrent infection syndrome, autosomal recessive10.1
26bronchiolitis10.0IGHE
27strongyloidiasis10.0IGHE
28urticaria10.0IGHE
29intrinsic asthma10.0IGHE
30eosinophilic gastroenteritis10.0IGHE
31tyrosine kinase 2 deficiency10.0TYK2
32measles10.0CD79A
33toxoplasmosis10.0CD79A
34mumps10.0CD79A
35pulmonary eosinophilia10.0IGHE
36omenn syndrome10.0IGHE
37pertussis10.0CD79A
38lupus erythematosus10.0CD79A
39autoimmune hemolytic anemia10.0CD79A
40tonsillitis10.0CD79A
41gastritis10.0CD79A
42rubella10.0CD79A
43glomerulonephritis10.0CD79A
44mycosis fungoides10.0STAT3
45bronchitis10.0CD79A
46gastroenteritis10.0CD79A
47diphtheria10.0CD79A
48hyperthyroidism10.0IGES
49neutropenia10.0STAT3
50pemphigus10.0CD79A

Graphical network of the top 20 diseases related to Job's Syndrome:



Diseases related to job's syndrome

Clinical Features for Job's Syndrome

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46OMIM
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Clinical features from OMIM:

147060

Drugs & Therapeutics for Job's Syndrome

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Job's Syndrome

Genetic Tests for Job's Syndrome

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Sources:
22GTR
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Genetic tests related to Job's Syndrome:

id Genetic test Affiliating Genes
1 Hyperimmunoglobulin E Syndrome22

Anatomical Context for Job's Syndrome

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32MalaCards
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MalaCards organs/tissues related to Job's Syndrome:

32
Colon, Lung, Eye, T cells

Animal Models for Job's Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Job's Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.6IFNG, IRAK4, STAT3, IGHE, TYK2, CD79A
2MP:00053846.9IFNG, IRAK4, STAT3, DOCK8, TYK2, CD79A
3MP:00053976.5IFNG, IRAK4, STAT3, DOCK8, IGHE, TYK2
4MP:00053876.3CLEC6A, CARD9, IFNG, IRAK4, STAT3, DOCK8

Publications for Job's Syndrome

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50PubMed
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Articles related to Job's Syndrome:

(show top 50)    (show all 75)
idTitleAuthorsYear
1
Free light chain assay: doing a "good job" in Job's syndrome. (23101694)
2013
2
Safety of major abdominal surgical procedures in patients with hyperimmunoglobulinemia E (Job's syndrome): a changing paradigm? (23188219)
2013
3
Serum free light chains as predictors of lymphomagenesis in patients with autosomal dominant hyper-immunoglobulin E syndrome (Job's syndrome). (23039380)
2013
4
Fungal infection of gingiva in a patient with hyperimmunoglobulin-E (Job's) syndrome. (23055595)
2012
5
Anesthesia in a patient with Job's syndrome (hyper IgE). Case report. (21334510)
2011
6
Th17 cells, Job's syndrome and HIV: opportunities for bacterial and fungal infections. (20543597)
2010
7
Hyper IgE (Job's) syndrome: a primary immune deficiency with oral manifestations. (19036057)
2009
8
Ophthalmic complications including retinal detachment in hyperimmunoglobulinemia E (Job's) syndrome: Case report and review of literature. (19700878)
2009
9
Recurrent hemoptysis with Penicillium marneffei and Stenotrophomonas maltophilia in Job's syndrome. (19707602)
2009
10
The development of pulmonary adenocarcinoma in a patient with Job's syndrome, a rare immunodeficiency condition. (15143986)
2004
11
Non-Hodgkin's lymphoma in Job's syndrome: a case report and literature review. (15621772)
2004
12
Disseminated pulmonary candidiasis complicating hyperimmunoglobulin E (Job's) syndrome. (14712133)
2004
13
Recurrent Staphylococcus aureus chalazia in hyperimmunoglobulinemia E (Job's) syndrome. (15629308)
2004
14
Generalized lymphadenopathy caused by Trichosporon asahii in a patient with Job's syndrome. (11862981)
2002
15
Clinical pathology case: hyperimmunoglobulin E syndrome (Job's syndrome). (11486352)
2001
16
Eye involvement in hyperimmunoglobulinemia E (Job's) syndrome. (11587182)
2001
17
Molluscum contagiosum and Job's syndrome. (11832646)
2001
18
Moderate-dose intravenous immunoglobulin treatment of Job's syndrome. Case report. (11084845)
2000
19
Job's syndrome. (11191445)
2000
20
The development of invasive vulvar cancer in a patient with Job's syndrome, a rare immunodeficient condition. (9609279)
1998
21
Case of the season. Job's syndrome with superimposed lymphoma. (8896101)
1996
22
Job's syndrome associated with HIV infection improved with immune globulin therapy. (8902088)
1996
23
Colon perforation in a patient with hyperimmunoglobulin E (Job's) syndrome. (8786494)
1995
24
Fungal pulmonary abscess in an adult secondary to hyperimmunoglobulin E (Job's) syndrome. (7887732)
1995
25
Job's syndrome or hyperimmunoglobulin-E. (8773078)
1995
26
An adult patient with hyperimmunoglobulemia E (Job's) syndrome, end-stage renal disease and repeated episodes of peritonitis. (8026117)
1994
27
Staphylococcal botryomycosis and hyperimmunoglobulin E (Job's) syndrome in an infant. (8425949)
1993
28
Job's syndrome: an unusual response to a common drug. (1616142)
1992
29
Pneumatocele complicating hyperimmunoglobulin E syndrome (Job's Syndrome). (1449312)
1992
30
Recurrent colonic histoplasmosis after standard therapy with amphotericin B in a patient with Job's syndrome. (1986542)
1991
31
Hyperimmunoglobulin E recurrent infection (Job's) syndrome. (1954139)
1991
32
Anesthetic management of a pregnant patient with the hyperimmunoglobulin E (Job's) syndrome. (2316888)
1990
33
Spinal anaesthesia in a child with Job's syndrome, pneumatoceles and empyema. (2356933)
1990
34
Job's syndrome: a rare cause of recurrent lung abscess in childhood. (2241394)
1990
35
Neonatal Job's syndrome featuring a vesicular eruption. (3412996)
1988
36
Evolution of the hyperimmunoglobulin E and recurrent infection (HIE, JOB's) syndrome in a young girl. (3680819)
1987
37
Elevated urinary histamine in the hyperimmunoglobulin E and recurrent infection (Job's) syndrome: association with eczematoid dermatitis and not with infection. (3819231)
1987
38
Ileocecal histoplasmosis mimicking Crohn's disease in a patient with Job's syndrome. (3949095)
1986
39
Immunoglobulins in the hyperimmunoglobulin E and recurrent infection (Job's) syndrome. Deficiency of anti-Staphylococcus aureus immunoglobulin A. (3871199)
1985
40
The hyperimmunoglobulin E recurrent-infection (Job's) syndrome. A review of the NIH experience and the literature. (6348470)
1983
41
Levamisole is inferior to placebo in the hyperimmunoglobulin E recurrent-infection (Job's) syndrome. (6806658)
1982
42
Levamisole in Job's syndrome. (7144828)
1982
43
Job's syndrome. (7401839)
1980
44
Cranial synostosis in Job's syndrome. (85845)
1978
45
Atopic dermatitis and impaired neutrophil chemotaxis in Job's syndrome. (869552)
1977
46
Defect in neutrophil granulocyte chemotaxis in Job's syndrome of recurrent "cold" staphylococcal abscesses. (4137601)
1974
47
Job's syndrome and chronic granulomatous disease. (5410153)
1970
48
Job's syndrome and chronic granulomatous disease. (5410154)
1970
49
Job's syndrome--a variant of chronic granulomatous disease. Report of a case. (5815897)
1969
50
Job's Syndrome. Recurrent, "cold", staphylococcal abscesses. (4161105)
1966

Genetic Variations for Job's Syndrome

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Expression for genes affiliated with Job's Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Job's Syndrome

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Pathways for genes affiliated with Job's Syndrome

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Sources:
12EMD Millipore, 51QIAGEN, 37NCBI BioSystems Database, 53Reactome, 29KEGG, 4Cell Signaling Technology, 52R&D Systems
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Pathways related to Job's Syndrome according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1TYK2
29.7TYK2, STAT3
39.7TYK2, STAT3
4
Immune response Oncostatin M signaling via JAK-Stat in human cells
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9.7TYK2, STAT3
59.7TYK2, STAT3
69.6IFNG, STAT3
7
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9.4TYK2, STAT3, IRAK4
89.4CARD9, IFNG, IRAK4
9
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9.3STAT3, IRAK4, IFNG
109.3TYK2, STAT3, IFNG
119.3TYK2, STAT3, IFNG
12
Development Thrombopoetin signaling via JAK-STAT pathway
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9.3IFNG, STAT3, TYK2
13
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9.3IFNG, STAT3, TYK2
14
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9.3IFNG, STAT3, TYK2
15
Development PDGF signaling via STATs and NF-kB
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9.3IFNG, STAT3, TYK2
16
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9.0CLEC6A, IRAK4, CARD9
17
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8.9TYK2, STAT3, IRAK4, IFNG
18
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8.9TYK2, STAT3, IRAK4, IFNG
19
Hide members
8.9TYK2, STAT3, IRAK4, IFNG
20
Hide members
8.9IFNG, IRAK4, STAT3, CD79A
21
Hide members
7.6CD79A, TYK2, IGHE, STAT3, IRAK4, IFNG

Compounds for genes affiliated with Job's Syndrome

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44Novoseek, 49PharmGKB, 11DrugBank, 2BitterDB, 59Tocris Bioscience, 28IUPHAR, 24HMDB
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Compounds related to Job's Syndrome according to GeneCards/GeneDecks:

(show all 30)
idCompoundScoreTop Affiliating Genes
1bucillamine4410.0CD79A, IFNG
2gamma globulin4410.0IFNG, CD79A
3tuberculin4410.0CD79A, IFNG
4adalimumab44 49 1111.9IFNG, CD79A
5isoniazid49 44 1111.9CD79A, IFNG
6unicap449.8CD79A, IGHE
7okt3449.8CD79A, IFNG
8sodium cromoglycate449.8IGHE, CD79A
9con a449.8IFNG, CD79A
10enterotoxin449.8CD79A, IGES
11praziquantel44 1110.8IGHE, CD79A
12penicillin449.8CD79A, IGHE
13gliadin449.8CD79A, IGHE
14silicone449.7IGHE, CD79A
15parthenolide44 210.7IFNG, STAT3
16ifn-alpha449.6IFNG, STAT3, TYK2
17budesonide44 49 1111.5IFNG, IGHE
18ivig449.4CD79A, IGHE, IFNG
19fluticasone propionate44 49 59 1112.4IGHE, IFNG
20prednisolone44 28 1111.4CD79A, IGHE, IFNG
21methacholine44 1110.3IGHE, IGES, CD79A
22salbutamol44 49 28 11 2413.2CD79A, IGHE
23n acetylcysteine449.1STAT3, IGHE, CD79A
24allergens448.9CD79A, IGES, IGHE, IFNG
25histamine44 28 2410.9IFNG, IGHE, IGES, CD79A
26dexamethasone44 49 28 1111.8IFNG, STAT3, IGHE, CD79A
27vegf448.8CD79A, IGHE, STAT3, IFNG
28retinoic acid44 249.6IFNG, STAT3, IGHE, TYK2, CD79A
29arginine448.5CD79A, IGHE, STAT3, IFNG
30cyclosporin a44 28 5910.5IFNG, STAT3, IGHE, IGES, CD79A

GO Terms for genes affiliated with Job's Syndrome

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16Gene Ontology
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Biological processes related to Job's Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of tumor necrosis factor productionGO:0327609.4IFNG, CARD9
2response to drugGO:0424939.3STAT3, IFNG, CARD9
3cytokine-mediated signaling pathwayGO:0192218.9TYK2, STAT3, IRAK4, IFNG
4innate immune responseGO:0450878.3CARD9, IRAK4, IGHE, CLEC6A

Products for genes affiliated with Job's Syndrome

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Sources for Job's Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet