MCID: JBS001
MIFTS: 48

Job's Syndrome malady

Immune diseases category
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Summaries for Job's Syndrome

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MalaCards based summary: Job's Syndrome, also known as hyperimmunoglobulin e syndrome, is related to autosomal dominant hyper ige syndrome and bullous pemphigoid. An important gene associated with Job's Syndrome is STAT3 (signal transducer and activator of transcription 3 (acute-phase response factor)), and among its related pathways are B Cell Receptor Signaling Pathway and Antigen Activates B Cell Receptor Leading to Generation of Second Messengers. The compounds unicap and sodium cromoglycate have been mentioned in the context of this disorder. Affiliated tissues include colon, neutrophil and lung, and related mouse phenotypes are renal/urinary system and hematopoietic system.

Description from OMIM:46 147060

Aliases & Classifications for Job's Syndrome

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Job's Syndrome, Aliases & Descriptions:

Name: Job's Syndrome 8 62
Hyperimmunoglobulin E Syndrome 8 22 62
 
Job Syndrome 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases


External Ids:

Disease Ontology8 DOID:3261
OMIM46 147060
NCIt39 C3144
MeSH34 D007589
ICD1025 D82.4

Related Diseases for Job's Syndrome

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Diseases related to Job's Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 73)
idRelated DiseaseScoreTop Affiliating Genes
1autosomal dominant hyper ige syndrome30.4IGES, STAT3, IFNG, IGHE
2bullous pemphigoid30.4IGHE, CD79A
3atopic dermatitis30.3IGHE, IGES, IFNG
4dermatitis29.9IGHE, CD79A, IFNG, IGES
5strongyloidiasis10.4IGHE
6intrinsic asthma10.4IGHE
7eosinophilic gastroenteritis10.4IGHE
8eczema herpeticum10.4IGHE
9malaria10.4IFNG
10necrotizing fasciitis10.3
11fasciitis10.3
12hyper ige syndrome10.3
13thyroiditis10.3CD79A
14allergic bronchopulmonary aspergillosis10.2IGES, IGHE
15kimura disease10.2IGHE, IGES
16asthma10.2IGES, IGHE
17chronic granulomatous disease10.2
18diabetes mellitus10.2
19osteochondritis dissecans10.2
20nocardiosis10.2
21pleuropneumonia10.2
22neonatal diabetes mellitus10.2
23folliculitis10.2
24molluscum contagiosum10.2
25pseudotumor cerebri10.2
26calcinosis10.2
27dermatomyositis10.2
28diarrhea10.2
29endocarditis10.2
30histoplasmosis10.2
31autosomal recessive hyper ige syndrome10.2
32eosinophilic pustular folliculitis10.2
33gianotti crosti syndrome10.2
34short stature10.2
35hyper-ige recurrent infection syndrome, autosomal recessive10.2
36food allergy10.2IGHE, IGES
37vernal keratoconjunctivitis10.2IGHE, IGES
38hypereosinophilic syndrome10.2IGES, IGHE
39pneumonia10.2CD79A, IGES
40immunoglobulin g deficiency10.2CD79A, IGHE
41respiratory failure10.2IGES, IGHE
42immunoglobulin alpha deficiency10.1IGHE, CD79A
43pulmonary tuberculosis10.1IFNG, IGES
44immunodeficiency with hyper igm type 110.1CD79A, IGHE
45aspergillosis10.1CD79A, IFNG
46candidiasis10.1IFNG, CD79A
47nephrotic syndrome10.0IGES, CD79A
48fournier gangrene10.0
49graves' disease10.0IFNG, IGES
50tetanus10.0CD79A, IFNG

Graphical network of the top 20 diseases related to Job's Syndrome:



Diseases related to job's syndrome

Symptoms for Job's Syndrome

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Clinical features from OMIM:

147060

Drugs & Therapeutics for Job's Syndrome

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Drug clinical trials:

Search ClinicalTrials for Job's Syndrome

Search NIH Clinical Center for Job's Syndrome

Genetic Tests for Job's Syndrome

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Genetic tests related to Job's Syndrome:

id Genetic test Affiliating Genes
1 Hyperimmunoglobulin E Syndrome22

Anatomical Context for Job's Syndrome

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MalaCards organs/tissues related to Job's Syndrome:

32
Colon, Neutrophil, Lung, Eye, T cells

Animal Models for Job's Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Job's Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.9CD79A, IFNG, STAT3
2MP:00053978.3CD79A, IFNG, STAT3, IGHE
3MP:00053878.1IGHE, STAT3, IFNG, CD79A

Publications for Job's Syndrome

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Articles related to Job's Syndrome:

(show top 50)    (show all 76)
idTitleAuthorsYear
1
A new case of Job's syndrome at the clinic: a diagnostic challenge. (24560409)
2014
2
Free light chain assay: doing a "good job" in Job's syndrome. (23101694)
2013
3
Safety of major abdominal surgical procedures in patients with hyperimmunoglobulinemia E (Job's syndrome): a changing paradigm? (23188219)
2013
4
Fungal infection of gingiva in a patient with hyperimmunoglobulin-E (Job's) syndrome. (23055595)
2012
5
Acupuncture for symptom management in patients with hyper-IgE (Job's) syndrome. (21208131)
2011
6
Anesthesia in a patient with Job's syndrome (hyper IgE). Case report. (21334510)
2011
7
Th17 cells, Job's syndrome and HIV: opportunities for bacterial and fungal infections. (20543597)
2010
8
Recurrent giant chalazia in hyperimmunoglobulin E (Job's) syndrome. (18528638)
2009
9
Hyper IgE (Job's) syndrome: a primary immune deficiency with oral manifestations. (19036057)
2009
10
Ophthalmic complications including retinal detachment in hyperimmunoglobulinemia E (Job's) syndrome: Case report and review of literature. (19700878)
2009
11
Recurrent hemoptysis with Penicillium marneffei and Stenotrophomonas maltophilia in Job's syndrome. (19707602)
2009
12
Methicillin-resistant Staphylococcus aureus (MRSA) mitral valve acute bacterial endocarditis (ABE) in a patient with Job's syndrome (hyperimmunoglobulin E syndrome) successfully treated with linezolid and high-dose daptomycin. (18206530)
2008
13
Hyperimmunoglobulin E syndrome (Job's syndrome). (19284090)
2008
14
The development of pulmonary adenocarcinoma in a patient with Job's syndrome, a rare immunodeficiency condition. (15143986)
2004
15
Non-Hodgkin's lymphoma in Job's syndrome: a case report and literature review. (15621772)
2004
16
Disseminated pulmonary candidiasis complicating hyperimmunoglobulin E (Job's) syndrome. (14712133)
2004
17
Job's syndrome--a case report. (14761145)
2003
18
Job's syndrome. A case report. (12700555)
2003
19
28-Year-Old Patient with Elevated Serum IgE Levels and Multiple Refractory Epidural and Paravertebral Abscesses. Clinical manifestation of a Job's Syndrome?]. (14551710)
2003
20
Generalized lymphadenopathy caused by Trichosporon asahii in a patient with Job's syndrome. (11862981)
2002
21
Meconium thorax: A case of Bochdalek hernia and cecal perforation in a neonate with Job's syndrome. (11912536)
2002
22
Clinical pathology case: hyperimmunoglobulin E syndrome (Job's syndrome). (11486352)
2001
23
Eye involvement in hyperimmunoglobulinemia E (Job's) syndrome. (11587182)
2001
24
Molluscum contagiosum and Job's syndrome. (11832646)
2001
25
Moderate-dose intravenous immunoglobulin treatment of Job's syndrome. Case report. (11084845)
2000
26
Job's syndrome. (11191445)
2000
27
Regulation of immunoglobulin production in hyper-IgE (Job's) syndrome. (9949327)
1999
28
Oral zinc in Job's syndrome. (20921729)
1998
29
Pneumatocele complicated by fungal lung abscess in Job's syndrome. Successful lobectomy with the aid of videothoracoscopy. (9264169)
1997
30
Case of the season. Job's syndrome with superimposed lymphoma. (8896101)
1996
31
Job's syndrome associated with HIV infection improved with immune globulin therapy. (8902088)
1996
32
A case of Job's syndrome]. (8675115)
1996
33
Colon perforation in a patient with hyperimmunoglobulin E (Job's) syndrome. (8786494)
1995
34
Fungal pulmonary abscess in an adult secondary to hyperimmunoglobulin E (Job's) syndrome. (7887732)
1995
35
An adult patient with hyperimmunoglobulemia E (Job's) syndrome, end-stage renal disease and repeated episodes of peritonitis. (8026117)
1994
36
Staphylococcal botryomycosis and hyperimmunoglobulin E (Job's) syndrome in an infant. (8425949)
1993
37
Job's syndrome: an unusual response to a common drug. (1616142)
1992
38
Pneumatocele complicating hyperimmunoglobulin E syndrome (Job's Syndrome). (1449312)
1992
39
Recurrent colonic histoplasmosis after standard therapy with amphotericin B in a patient with Job's syndrome. (1986542)
1991
40
Cryptococcosis of the colon resembling Crohn's disease in a patient with the hyperimmunoglobulinemia E-recurrent infection (Job's) syndrome. (3338649)
1988
41
Neonatal Job's syndrome featuring a vesicular eruption. (3412996)
1988
42
Evolution of the hyperimmunoglobulin E and recurrent infection (HIE, JOB's) syndrome in a young girl. (3680819)
1987
43
Elevated urinary histamine in the hyperimmunoglobulin E and recurrent infection (Job's) syndrome: association with eczematoid dermatitis and not with infection. (3819231)
1987
44
Ileocecal histoplasmosis mimicking Crohn's disease in a patient with Job's syndrome. (3949095)
1986
45
Immunoglobulins in the hyperimmunoglobulin E and recurrent infection (Job's) syndrome. Deficiency of anti-Staphylococcus aureus immunoglobulin A. (3871199)
1985
46
Esophageal cryptococcosis in a patient with the hyperimmunoglobulin E-recurrent infection (Job's) syndrome. (6373479)
1984
47
Levamisole is inferior to placebo in the hyperimmunoglobulin E recurrent-infection (Job's) syndrome. (6806658)
1982
48
Atopic dermatitis and impaired neutrophil chemotaxis in Job's syndrome. (869552)
1977
49
Job's syndrome and chronic granulomatous disease. (5410629)
1970
50
Job's syndrome--a variant of chronic granulomatous disease. Report of a case. (5815897)
1969

Variations for Job's Syndrome

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Clinvar genetic disease variations for Job's Syndrome:

6
id Gene Name Type Significance SNP ID Assembly Location
1STAT3NM_139276.2(STAT3): c.1387_1389delGTG (p.Val463del)deletionPathogenicrs113994138GRCh37Chr 17, 40477056: 40477058
2STAT3NM_139276.2(STAT3): c.1144C> T (p.Arg382Trp)single nucleotide variantPathogenicrs113994135GRCh37Chr 17, 40481661: 40481661
3STAT3NM_139276.2(STAT3): c.1145G> A (p.Arg382Gln)single nucleotide variantPathogenicrs113994136GRCh37Chr 17, 40481660: 40481660
4STAT3NM_139276.2(STAT3): c.1268G> A (p.Arg423Gln)single nucleotide variantPathogenicrs113994137GRCh37Chr 17, 40481441: 40481441
5STAT3NM_139276.2(STAT3): c.1909G> A (p.Val637Met)single nucleotide variantPathogenicrs113994139GRCh37Chr 17, 40474492: 40474492
6STAT3NM_139276.2(STAT3): c.1166C> T (p.Thr389Ile)single nucleotide variantPathogenicrs397514766GRCh37Chr 17, 40481639: 40481639

Expression for genes affiliated with Job's Syndrome

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Expression patterns in normal tissues for genes affiliated with Job's Syndrome

Search GEO for disease gene expression data for Job's Syndrome.

Pathways for genes affiliated with Job's Syndrome

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Pathways related to Job's Syndrome according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5STAT3, CD79A
2
Show member pathways
9.4CD79A, IGHE
3
Show member pathways
Immune response T cell receptor signaling pathway60
Immune response CD28 signaling60
Immune response ICOS pathway in T helper cell60
9.4CD79A, IGHE
4
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.4IFNG, STAT3
59.4IFNG, STAT3
69.4STAT3, IFNG
7
Show member pathways
9.4STAT3, IFNG
8
Show member pathways
9.4IFNG, STAT3
9
Show member pathways
Type III interferon signaling37
9.4IFNG, STAT3
10
Show member pathways
Immune response IL 12 induced IFN gamma production60
9.4STAT3, IFNG
11
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway60
9.4STAT3, IFNG
129.4STAT3, IFNG
139.4IFNG, STAT3
149.4IFNG, STAT3
15
Show member pathways
IL27-mediated signaling events37
9.4IFNG, STAT3
16
Show member pathways
IL-2 Signaling pathway37
9.4IFNG, STAT3
17
Show member pathways
9.4STAT3, IFNG
18
Show member pathways
IFN-gamma pathway37
9.4IFNG, STAT3
19
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
9.3CD79A, IFNG
20
Show member pathways
Immune response BCR pathway60
Fc-epsilon receptor I signaling in mast cells37
9.0CD79A, STAT3, IGHE
21
Show member pathways
8.9CD79A, IFNG, STAT3

Compounds for genes affiliated with Job's Syndrome

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Compounds related to Job's Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 68)
idCompoundScoreTop Affiliating Genes
1unicap449.9CD79A, IGHE
2sodium cromoglycate449.9IGHE, CD79A
3praziquantel44 1110.8IGHE, CD79A
4penicillin449.8CD79A, IGHE
5gliadin449.8CD79A, IGHE
6silicone449.8IGHE, CD79A
7pertussis449.8IGHE, STAT3
8bucillamine449.8CD79A, IFNG
9salbutamol44 50 28 24 1113.8CD79A, IGHE
10gamma globulin449.8IFNG, CD79A
11parthenolide44 210.7STAT3, IFNG
12tuberculin449.7CD79A, IFNG
13adalimumab44 50 1111.7CD79A, IFNG
14isoniazid44 50 1111.7IFNG, CD79A
15polyinosinic-polycytidylic acid449.7IFNG, STAT3
16okt3449.7CD79A, IFNG
17con a449.7CD79A, IFNG
18budesonide44 50 1111.7IGHE, IFNG
19fluticasone propionate44 50 61 1112.7IFNG, IGHE
20mycophenolate mofetil44 50 1111.6CD79A, IFNG
21l-nmma449.6IGHE, IFNG
22anti-fungal449.6CD79A, IFNG
23tarc449.6IGHE, IFNG
24ribavirin44 50 1111.5IFNG, STAT3
25infliximab44 50 1111.5IGHE, IFNG
26ifn-alpha449.5STAT3, IFNG
27enterotoxin449.5IGES, CD79A
28rituximab44 50 1111.5CD79A, STAT3
29melphalan44 50 1111.4CD79A, IFNG
30n acetylcysteine449.4CD79A, STAT3, IGHE
31neopterin449.3IFNG, CD79A
3215-deoxy-delta-12,14-prostaglandin j2449.3IFNG, STAT3
33heparin44 28 24 1112.3CD79A, STAT3, IGHE
34ivig449.3IGHE, IFNG, CD79A
35prednisolone44 28 1111.2CD79A, IFNG, IGHE
36actinomycin d449.2IFNG, STAT3, IGHE
37indomethacin44 28 61 1112.2IGHE, IFNG, CD79A
38pge2449.2STAT3, IFNG, CD79A
39methacholine44 50 1111.1CD79A, IGHE, IGES
40cycloheximide449.1IGHE, STAT3, IFNG
41acetylcholine44 50 28 24 1113.0CD79A, IGHE, IGES
42lactate448.9CD79A, IGHE, IGES
43dexamethasone44 50 28 1111.8IGHE, STAT3, IFNG, CD79A
44vegf448.8IGHE, STAT3, IFNG, CD79A
45arginine448.8CD79A, IFNG, STAT3, IGHE
46retinoic acid44 249.8CD79A, IFNG, STAT3, IGHE
47testosterone44 61 24 1111.7CD79A, STAT3, IGHE
48allergens448.4CD79A, IFNG, IGHE, IGES
49histamine44 28 2410.4IGES, IGHE, IFNG, CD79A
50cyclosporin a44 28 6110.0IGES, IGHE, STAT3, IFNG, CD79A

GO Terms for genes affiliated with Job's Syndrome

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Biological processes related to Job's Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular component movementGO:0069289.4IFNG, STAT3

Products for genes affiliated with Job's Syndrome

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Sources for Job's Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet