MCID: JBS001
MIFTS: 43

Job's Syndrome malady

Immune category

Summaries for Job's Syndrome

Sources:
47OMIM, 33MalaCards
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MalaCards: Job's Syndrome, also known as hyperimmunoglobulin e syndrome, is related to hyper ige syndrome and bullous pemphigoid. An important gene associated with Job's Syndrome is CARD9 (caspase recruitment domain family, member 9), and among its related pathways are Immune response IL-12 signaling pathway and IL-10 Pathway. The compounds bucillamine and gamma globulin have been mentioned in the context of this disorder. Affiliated tissues include colon, lung and t cells, and related mouse phenotypes are homeostasis/metabolism and cellular.

Description from OMIM:47 147060

Aliases & Classifications for Job's Syndrome

Sources:
8Disease Ontology, 22GTR, 61UMLS, 35MeSH, 40NCIt, 47OMIM, 57SNOMED-CT, 25ICD10
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Related Diseases for Job's Syndrome

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Job's Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 106)
idRelated DiseaseScoreTop Affiliating Genes
1hyper ige syndrome30.6IFNG, STAT3, IGHE, IGES
2bullous pemphigoid30.2CD79A, IGHE
3atopic dermatitis30.2IGES, IGHE, IFNG
4n syndrome10.5
5necrotizing fasciitis10.3
6pleuropneumonia10.2
7crohn's disease10.2
8molluscum contagiosum10.2
9pseudotumor cerebri10.2
10chronic granulomatous disease10.2
11nocardiosis10.2
12neonatal diabetes mellitus10.2
13osteochondritis dissecans10.2
14autosomal recessive disease10.2
15autosomal dominant hyper ige syndrome10.2
16short syndrome10.2
17gianotti crosti syndrome10.2
18autosomal recessive hyper ige syndrome10.2
19short stature10.2
20hyper-ige recurrent infection syndrome, autosomal recessive10.2
21bronchiolitis10.0IGHE
22strongyloidiasis10.0IGHE
23urticaria10.0IGHE
24intrinsic asthma10.0IGHE
25eosinophilic gastroenteritis10.0IGHE
26tyrosine kinase 2 deficiency10.0TYK2
27measles10.0CD79A
28toxoplasmosis10.0CD79A
29mumps10.0CD79A
30pulmonary eosinophilia10.0IGHE
31omenn syndrome10.0IGHE
32pertussis10.0CD79A
33lupus erythematosus10.0CD79A
34autoimmune hemolytic anemia10.0CD79A
35tonsillitis10.0CD79A
36gastritis10.0CD79A
37rubella10.0CD79A
38glomerulonephritis10.0CD79A
39mycosis fungoides10.0STAT3
40bronchitis10.0CD79A
41gastroenteritis10.0CD79A
42diphtheria10.0CD79A
43hyperthyroidism10.0IGES
44neutropenia10.0STAT3
45pemphigus10.0CD79A
46cholera10.0CD79A
47cystic fibrosis10.0IGES
48myocardial infarction10.0IGES
49pancreatitis10.0IGES
50lymphadenitis10.0CD79A

Graphical network of the top 20 diseases related to Job's Syndrome:



Diseases related to job's syndrome

Clinical Features for Job's Syndrome

Sources:
47OMIM
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Clinical features from OMIM:

147060

Drugs & Therapeutics for Job's Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Job's Syndrome

Drug clinical trials:

Search ClinicalTrials for Job's Syndrome

Search NIH Clinical Center for Job's Syndrome

Search CenterWatch for Job's Syndrome

Genetic Tests for Job's Syndrome

Sources:
22GTR
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Genetic tests related to Job's Syndrome:

id Genetic test Affiliating Genes
1 Hyperimmunoglobulin E Syndrome22

Anatomical Context for Job's Syndrome

Sources:
33MalaCards
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MalaCards organs/tissues related to Job's Syndrome:

33
Colon, Lung, T cells, B cells

Animal Models for Job's Syndrome or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Job's Syndrome

Sources:
51PubMed
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Articles related to Job's Syndrome:

(show top 50)    (show all 75)
idTitleAuthorsYear
1
Free light chain assay: doing a "good job" in Job's syndrome. (23101694)
2013
2
Job's syndrome with an atypical presentation. (24392534)
2013
3
Rectal histoplasmosis in Job's syndrome. (23151895)
2013
4
Acupuncture for symptom management in patients with hyper-IgE (Job's) syndrome. (21208131)
2011
5
Recurrent giant chalazia in hyperimmunoglobulin E (Job's) syndrome. (18528638)
2009
6
Ophthalmic complications including retinal detachment in hyperimmunoglobulinemia E (Job's) syndrome: Case report and review of literature. (19700878)
2009
7
Methicillin-resistant Staphylococcus aureus (MRSA) mitral valve acute bacterial endocarditis (ABE) in a patient with Job's syndrome (hyperimmunoglobulin E syndrome) successfully treated with linezolid and high-dose daptomycin. (18206530)
2008
8
Hyperimmunoglobulin E syndrome (Job's syndrome). (19284090)
2008
9
STAT3 mutation in the original patient with Job's syndrome. (17942886)
2007
10
Peripheral T-cell lymphoma and Job's syndrome: a rare association. (16645241)
2006
11
The development of pulmonary adenocarcinoma in a patient with Job's syndrome, a rare immunodeficiency condition. (15143986)
2004
12
Non-Hodgkin's lymphoma in Job's syndrome: a case report and literature review. (15621772)
2004
13
Disseminated pulmonary candidiasis complicating hyperimmunoglobulin E (Job's) syndrome. (14712133)
2004
14
Importance of life-long continuous antimicrobial prophylaxis to prevent infections in patients with Job's syndrome. (15325512)
2004
15
Job's syndrome. (15250440)
2004
16
Job's syndrome--a case report. (14761145)
2003
17
Job's syndrome. A case report. (12700555)
2003
18
28-Year-Old Patient with Elevated Serum IgE Levels and Multiple Refractory Epidural and Paravertebral Abscesses. Clinical manifestation of a Job's Syndrome?]. (14551710)
2003
19
Meconium thorax: A case of Bochdalek hernia and cecal perforation in a neonate with Job's syndrome. (11912536)
2002
20
Clinical pathology case: hyperimmunoglobulin E syndrome (Job's syndrome). (11486352)
2001
21
Eye involvement in hyperimmunoglobulinemia E (Job's) syndrome. (11587182)
2001
22
Molluscum contagiosum and Job's syndrome. (11832646)
2001
23
Regulation of immunoglobulin production in hyper-IgE (Job's) syndrome. (9949327)
1999
24
Oral zinc in Job's syndrome. (20921729)
1998
25
The development of invasive vulvar cancer in a patient with Job's syndrome, a rare immunodeficient condition. (9609279)
1998
26
Pneumatocele complicated by fungal lung abscess in Job's syndrome. Successful lobectomy with the aid of videothoracoscopy. (9264169)
1997
27
A case of Job's syndrome]. (8675115)
1996
28
Colon perforation in a patient with hyperimmunoglobulin E (Job's) syndrome. (8786494)
1995
29
Job's syndrome or hyperimmunoglobulin-E. (8773078)
1995
30
Staphylococcal botryomycosis and hyperimmunoglobulin E (Job's) syndrome in an infant. (8425949)
1993
31
Job's syndrome: an unusual response to a common drug. (1616142)
1992
32
Hyperimmunoglobulin E recurrent infection (Job's) syndrome. (1954139)
1991
33
Anesthetic management of a pregnant patient with the hyperimmunoglobulin E (Job's) syndrome. (2316888)
1990
34
Job's syndrome (granulomatous disease variant). (2234765)
1990
35
Job's syndrome: a rare cause of recurrent lung abscess in childhood. (2241394)
1990
36
Cryptococcosis of the colon resembling Crohn's disease in a patient with the hyperimmunoglobulinemia E-recurrent infection (Job's) syndrome. (3338649)
1988
37
Neonatal Job's syndrome featuring a vesicular eruption. (3412996)
1988
38
Evolution of the hyperimmunoglobulin E and recurrent infection (HIE, JOB's) syndrome in a young girl. (3680819)
1987
39
Ileocecal histoplasmosis mimicking Crohn's disease in a patient with Job's syndrome. (3949095)
1986
40
Immunoglobulins in the hyperimmunoglobulin E and recurrent infection (Job's) syndrome. Deficiency of anti-Staphylococcus aureus immunoglobulin A. (3871199)
1985
41
Esophageal cryptococcosis in a patient with the hyperimmunoglobulin E-recurrent infection (Job's) syndrome. (6373479)
1984
42
Deficiency in C3b receptors on neutrophils of patients with chronic granulomatous disease and hyperimmunoglobulin-E recurrent infection (Job's) syndrome. (6240460)
1984
43
Cranial synostosis in Job's syndrome. (85845)
1978
44
Atopic dermatitis and impaired neutrophil chemotaxis in Job's syndrome. (869552)
1977
45
Job's syndrome and chronic granulomatous disease. (5410629)
1970
46
Job's syndrome and chronic granulomatous disease. (5410153)
1970
47
Job's syndrome. (4903095)
1970
48
Job's syndrome and chronic granulomatous disease. (5410154)
1970
49
Leucocytes in Job's syndrome. (4180157)
1969
50
Job's Syndrome. Recurrent, "cold", staphylococcal abscesses. (4161105)
1966

Genetic Variations for Job's Syndrome

Expression for genes affiliated with Job's Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Job's Syndrome

Search GEO for disease gene expression data for Job's Syndrome.

Pathways for genes affiliated with Job's Syndrome

Sources:
12EMD Millipore, 52QIAGEN, 38NCBI BioSystems Database, 54Reactome, 30KEGG, 4Cell Signaling Technology, 53R&D Systems
See all sources

Pathways related to Job's Syndrome according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1TYK2
29.7TYK2, STAT3
39.7TYK2, STAT3
4
Immune response Oncostatin M signaling via JAK-Stat in human cells
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9.7TYK2, STAT3
59.7TYK2, STAT3
69.6IFNG, STAT3
7
Hide members
9.4TYK2, STAT3, IRAK4
89.4CARD9, IFNG, IRAK4
9
Hide members
9.3STAT3, IRAK4, IFNG
109.3TYK2, STAT3, IFNG
119.3TYK2, STAT3, IFNG
12
Development Thrombopoetin signaling via JAK-STAT pathway
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9.3IFNG, STAT3, TYK2
13
Hide members
9.3IFNG, STAT3, TYK2
14
Hide members
9.3IFNG, STAT3, TYK2
15
Development PDGF signaling via STATs and NF-kB
Hide members
9.3IFNG, STAT3, TYK2
16
Hide members
9.0CLEC6A, IRAK4, CARD9
17
Hide members
8.9TYK2, STAT3, IRAK4, IFNG
18
Hide members
8.9TYK2, STAT3, IRAK4, IFNG
19
Hide members
8.9TYK2, STAT3, IRAK4, IFNG
20
Hide members
8.9IFNG, IRAK4, STAT3, CD79A
21
Hide members
7.6CD79A, TYK2, IGHE, STAT3, IRAK4, IFNG

Compounds for genes affiliated with Job's Syndrome

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 2BitterDB, 60Tocris Bioscience, 29IUPHAR, 24HMDB
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Compounds related to Job's Syndrome according to GeneCards/GeneDecks:

(show all 30)
idCompoundScoreTop Affiliating Genes
1bucillamine4510.0CD79A, IFNG
2gamma globulin4510.0IFNG, CD79A
3tuberculin4510.0CD79A, IFNG
4adalimumab45 50 1111.9IFNG, CD79A
5isoniazid50 45 1111.9CD79A, IFNG
6unicap459.8CD79A, IGHE
7okt3459.8CD79A, IFNG
8sodium cromoglycate459.8IGHE, CD79A
9con a459.8IFNG, CD79A
10enterotoxin459.8CD79A, IGES
11praziquantel45 1110.8IGHE, CD79A
12penicillin459.8CD79A, IGHE
13gliadin459.8CD79A, IGHE
14silicone459.7IGHE, CD79A
15parthenolide45 210.7IFNG, STAT3
16ifn-alpha459.6IFNG, STAT3, TYK2
17budesonide45 50 1111.5IFNG, IGHE
18ivig459.4CD79A, IGHE, IFNG
19fluticasone propionate45 50 60 1112.4IGHE, IFNG
20prednisolone45 29 1111.4CD79A, IGHE, IFNG
21methacholine45 1110.3IGHE, IGES, CD79A
22salbutamol45 50 29 11 2413.2CD79A, IGHE
23n acetylcysteine459.1STAT3, IGHE, CD79A
24allergens458.9CD79A, IGES, IGHE, IFNG
25histamine45 29 2410.9IFNG, IGHE, IGES, CD79A
26dexamethasone45 50 29 1111.8IFNG, STAT3, IGHE, CD79A
27vegf458.8CD79A, IGHE, STAT3, IFNG
28retinoic acid45 249.6IFNG, STAT3, IGHE, TYK2, CD79A
29arginine458.5CD79A, IGHE, STAT3, IFNG
30cyclosporin a45 29 6010.5IFNG, STAT3, IGHE, IGES, CD79A

GO Terms for genes affiliated with Job's Syndrome

Sources:
16Gene Ontology
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Biological processes related to Job's Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of tumor necrosis factor productionGO:0327609.4IFNG, CARD9
2response to drugGO:0424939.3STAT3, IFNG, CARD9
3cytokine-mediated signaling pathwayGO:0192218.9TYK2, STAT3, IRAK4, IFNG
4innate immune responseGO:0450878.3CARD9, IRAK4, IGHE, CLEC6A

Products for genes affiliated with Job's Syndrome

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  • Proteins
  • Lysates
  • Antibodies

Sources for Job's Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet