Aliases & Classifications for Joint Disorders

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Summaries for Joint Disorders

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MedlinePlus:32 A joint is where two or more bones come together, like the knee, hip, elbow, or shoulder. joints can be damaged by many types of injuries or diseases, including arthritis - inflammation of a joint. it causes pain, stiffness, and swelling. over time, the joint can become severely damaged. bursitis - inflammation of a fluid-filled sac that cushions the joint dislocations - injuries that force the ends of the bones out of position treatment of joint problems depends on the cause. if you have a sports injury, treatment often begins with the rice (rest, ice, compression, and elevation) method to relieve pain, reduce swelling, and speed healing. other possible treatments include pain relievers, keeping the injured area from moving, rehabilitation, and sometimes surgery. for arthritis, injuries, or other diseases, you may need joint replacement surgery to remove the damaged joint and put in a new one. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards based summary: Joint Disorders, also known as arthropathy, is related to arthritis and psoriatic arthritis. An important gene associated with Joint Disorders is SERPINB2 (serpin peptidase inhibitor, clade B (ovalbumin), member 2), and among its related pathways are Osteoblast Signaling and Osteoclast Signaling. The compounds polymyxin b and filgrastim have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and brain, and related mouse phenotypes are craniofacial and tumorigenesis.

Wikipedia:64 An arthropathy is a disease of a joint. more...

Related Diseases for Joint Disorders

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Diseases related to Joint Disorders via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 145)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis29.6TNF, TNFSF11, TIMP1, MMP3, IL6
2psoriatic arthritis29.4TNF, TNFSF11, TNFRSF11B, MMP3, IL1RAPL2
3juvenile rheumatoid arthritis29.0TNF, IL1R1, IL1RAPL2, IL1RN, IL18R1, IL6
4osteoarthritis27.8TNF, TNFSF11, TNFRSF11B, TIMP1, SERPINB2, MMP3
5rheumatoid arthritis27.1IL11, IL1R1, IL1R2, IL1RAPL2, IL1RN, IL18R1
6periapical granuloma10.6TNFSF11
7dengue shock syndrome10.6IL1RN
8pigmented villonodular synovitis10.5CSF1
9hyper-igd syndrome10.5IL1RN
10periodontitis10.5TNFRSF11B
11cherubism10.5TNFSF11
12malignant histiocytosis10.5CSF1
13blau syndrome10.5TNF
14schnitzler syndrome10.4IL1RN, IL1R1
15pulpitis10.4TIMP1
16paget disease, juvenile10.4TNFSF11, TNFRSF11B
17osteolysis, familial expansile10.4TNFSF11, TNFRSF11B
18stomatitis10.4IL11
19megakaryocytic leukemia10.4IL11, IL6R
20giant cell tumor10.4TNFSF11, CSF1
21alopecia areata10.4IL1R1, IL1RN
22neisseria meningitidis infection10.4IL1R1, IL1RN
23hyperostosis, endosteal10.3TNFSF11, TNFRSF11B
24marchiafava bignami disease10.3TNFRSF11B, TNFSF11
25aortic valve disease 210.3TNFSF11, TNFRSF11B
26refractory anemia10.3IL11, CSF1
27conjunctivochalasis10.3MMP3, TIMP1
28hematologic cancer10.3SERPINB2, IL11, CSF1
29neutropenia10.3CSF1, IL1RN, IL11
30polymyalgia rheumatica10.3IL1RN, IL1RAPL2
31hodgkin lymphoma10.3IL1RN, IL18R1, IL6R
32osteopetrosis10.2TNFSF11, TNFRSF11B, CSF1
33bone cancer10.2TNFSF11, TNFRSF11B, CSF1
34bronchopulmonary dysplasia10.2TIMP1, IL1RN
35thalassemia, hispanic gamma-delta-beta10.2TNFRSF11B, TNFSF11
36relapsing-remitting multiple sclerosis10.2TIMP1, IL1RN
37acute respiratory distress syndrome10.2TNF, IL1R1
38cholesteatoma10.2TNFSF11, TNFRSF11B, MMP3
39muckle-wells syndrome10.2IL1R1, IL1RAPL2
40gastritis10.2IL1RAPL2, IL1RN
41gingival overgrowth10.2TIMP1, MMP3
42acute graft versus host disease10.2TNF, IL1R1, IL1RN
43uveitis10.2TNF, IL1R1, IL18R1
44multicentric castleman’s disease10.2IL6R, IL6
45multiple myeloma10.2TNFSF11, IL6
46sarcoma10.2SERPINB2, IL1R1, IL18R1, CSF1
47pancreatic cancer10.2SERPINB2, IL1RN, IL18R1, IL6R
48spondylarthropathy10.1IL1RAPL2, TNF
49kawasaki disease10.1TIMP1, MMP3
50cinca syndrome10.1IL1R1, IL1RAPL2, IL1RN

Graphical network of the top 20 diseases related to Joint Disorders:



Diseases related to joint disorders

Symptoms for Joint Disorders

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Drugs & Therapeutics for Joint Disorders

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Drug clinical trials:

Search ClinicalTrials for Joint Disorders

Search NIH Clinical Center for Joint Disorders

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Joint Disorders cell therapies at LifeMap Discovery.

Genetic Tests for Joint Disorders

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Anatomical Context for Joint Disorders

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MalaCards organs/tissues related to Joint Disorders:

31
Bone, Skin, Brain

Animal Models for Joint Disorders or affiliated genes

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Publications for Joint Disorders

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Articles related to Joint Disorders:

(show all 48)
idTitleAuthorsYear
1
Stakeholder engagement analysis - a bioethics dilemma in patient-targeted intervention: patients with temporomandibular joint disorders. (25600231)
2015
2
Modeling of muscle forces in humans with and without temporomandibular joint disorders. (25865546)
2015
3
Cell therapy in joint disorders. (25553210)
2015
4
A pilot study of ambulatory masticatory muscle activities in temporomandibular joint disorders diagnostic groups. (25865543)
2015
5
Contemporary management of temporomandibular joint disorders. (25483451)
2015
6
Bone and Joint Disorders in Acromegaly. (25633971)
2015
7
Synovial plicae and temporomandibular joint disorders: surgical findings. (25795190)
2015
8
Sacroiliac joint disorders in Abidjan: Epidemiological, clinical, radiological and etiological characteristics. (25860679)
2014
9
Comparing proton density and turbo spin echo T2 weighted static sequences with dynamic half-Fourier single-shot TSE pulse sequence at 3.0a88T in diagnosis of temporomandibular joint disorders: a prospective study. (24720606)
2014
10
Joint motion quality in vibroacoustic signal analysis for patients with patellofemoral joint disorders. (25496721)
2014
11
Cytopathologic diagnosis on joint lavage fluid for patients with temporomandibular joint disorders. (23904326)
2014
12
Pisotriquetral joint disorders: an under-recognized cause of ulnar side wrist pain. (24687844)
2014
13
Effectiveness of a home exercise program in combination with ultrasound therapy for temporomandibular joint disorders. (25540479)
2014
14
Comprehensive treatment of temporomandibular joint disorders. (24660643)
2014
15
Brain signature of chronic orofacial pain: a systematic review and meta-analysis on neuroimaging research of trigeminal neuropathic pain and temporomandibular joint disorders. (24759798)
2014
16
Quantitative measurements of the articular areas of mandibular condyles with temporomandibular joint disorders using magnetic resonance imaging. (25519808)
2014
17
Tibial tubercle osteotomy for patello-femoral joint disorders. (25326765)
2014
18
The use of low level laser therapy in the treatment of temporomandibular joint disorders. Review of the literature. (23722130)
2013
19
Oral splint for temporomandibular joint disorders with revolutionary fluid system. (24019797)
2013
20
Symptoms resembling temporomandibular joint disorder caused by a pleomorphic adenoma. (23763725)
2013
21
Arthrocentesis and temporomandibular joint disorders: clinical and radiological results of a prospective study. (24319462)
2013
22
Clinical-surgical treatment of temporomandibular joint disorder in a psoriatic arthritis patient. (23556553)
2013
23
Evaluation of Korean teenagers with temporomandibular joint disorders. (24471050)
2013
24
Clinical signs and symptoms of tinnitus in temporomandibular joint disorders: a pilot study comparing patients and non-patients. (25158368)
2013
25
CT Images of a Severe TMJ Osteoarthritis and Differential Diagnosis with Other Joint Disorders. (24381768)
2013
26
Surgical classification for temporomandibular joint disorders. (23787136)
2013
27
Evidence Based Approach for the Diagnosis of Temporomandibular Joint Disorders (TMD). (24431765)
2013
28
The importance of complementary exams for the diagnosis of temporomandibular joint disorders. (23768880)
2013
29
Response to letter to the editor by the American Society of Temporomandibular Joint Surgeons (ASTMJS) Re: G. Dimitroulis, a new surgical classification for temporomandibular joint disorders [Int. J. Oral Maxillofac. Surg. 42 (2013) 218-222]. (23773237)
2013
30
Intra-articular injections with corticosteroids and sodium hyaluronate for treating temporomandibular joint disorders: a systematic review. (24352399)
2013
31
WITHDRAWN: Hyaluronate for temporomandibular joint disorders. (24105378)
2013
32
Etiological factors of temporomandibular joint disorders. (23833510)
2012
33
Nasal obstruction may alleviate bruxism related temporomandibular joint disorders. (21041035)
2011
34
Increased levels of soluble cytokine receptors in the synovial fluid of temporomandibular joint disorders in relation to joint effusion on magnetic resonance images. (20149511)
2010
35
Assessing potential functionality of catechol-O-methyltransferase (COMT) polymorphisms associated with pain sensitivity and temporomandibular joint disorders. (20336436)
2010
36
Conservative care of temporomandibular joint disorder in a 35-year-old patient with spinal muscular atrophy type III: a case study. (19948309)
2009
37
Cutaneous events during treatment of chronic inflammatory joint disorders with anti-tumour necrosis factor alpha: a cross-sectional study. (18713230)
2008
38
Induction of osteoclast-like cells derived from the synovial lavage fluids of patients with temporomandibular joint disorders. (16979913)
2007
39
Gene therapy methods in bone and joint disorders. Evaluation of the adeno-associated virus vector in experimental models of articular cartilage disorders, periprosthetic osteolysis and bone healing. (17427340)
2007
40
Expression of receptor activator of nuclear factor-kappaB ligand in synovial tissue: comparison with degradation of articular cartilage in temporomandibular joint disorders. (17560137)
2007
41
Increase in RANKL: OPG ratio in synovia of patients with temporomandibular joint disorder. (16798863)
2006
42
Analysis of tumor necrosis factor-alpha, interleukin-6, interleukin-1beta, soluble tumor necrosis factor receptors I and II, interleukin-6 soluble receptor, interleukin-1 soluble receptor type II, interleukin-1 receptor antagonist, and protein in the synovial fluid of patients with temporomandibular joint disorders. (15716832)
2005
43
Interleukin-6 family of cytokines as biochemical markers of osseous changes in the temporomandibular joint disorders. (15121272)
2004
44
Expression of osteoprotegerin in synovial tissue and degradation of articular cartilage: comparison with arthroscopic findings of temporomandibular joint disorders. (12973279)
2003
45
Biomarkers of joint tissue metabolism in canine osteoarthritic and arthritic joint disorders. (12202124)
2002
46
Plasminogen activators and plasminogen activator inhibitors in synovial fluid. Difference between inflammatory joint disorders and osteoarthritis. (8441174)
1993
47
Ulnar variance in children--standard measurements for evaluation of ulnar shortening in juvenile rheumatoid arthritis, hereditary multiple exostosis and other bone or joint disorders in childhood. (2588029)
1989
48
Cervical spondylosis presenting as the facial pain of temporomandibular joint disorder. (5658372)
1968

Variations for Joint Disorders

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Expression for genes affiliated with Joint Disorders

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Search GEO for disease gene expression data for Joint Disorders.

Pathways for genes affiliated with Joint Disorders

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Pathways related to Joint Disorders according to GeneCards Suite gene sharing:

(show all 44)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9TNFRSF11B, TNFSF11
29.9TNFSF11, TNFRSF11B
39.7CSF1, TNF
49.5SERPINB2, IL6, IL6R
59.5IL6, TNF
6
Show member pathways
9.5IL6R, IL6, IL1R1
79.4TNFSF11, TNF, IL1R1
8
Show member pathways
9.4TNFRSF11B, TNFSF11, TNF
9
Show member pathways
9.4TNFRSF11B, TNFSF11, TNF
109.3IL6R, IL6, TIMP1
11
Show member pathways
Serotonin Transporter Activity36
9.3IL1R1, TNFRSF11B, TNF
12
Show member pathways
IL-1 Signaling Pathway36
IL1-mediated signaling events36
9.3IL1R1, IL1R2, IL1RN
13
Show member pathways
9.3TNF, IL18R1, IL6
14
Show member pathways
IL27-mediated signaling events36
9.3TNF, IL18R1, IL6
159.2IL6R, IL6, TNF
16
Show member pathways
9.2MMP3, TIMP1, TNF
179.2IL6, TNF, CSF1
18
Show member pathways
Immune response MIF in innate immunity response59
9.2IL6, TNF, IL1R1
199.2IL1R1, IL6, TNF
209.1TNFSF11, IL6, TIMP1, IL6R
219.1IL6, IL1R2, MMP3
229.0IL1RN, IL6R, IL6, TNF
23
Show member pathways
Type III interferon signaling36
8.9IL6, IL11, IL6R
24
Show member pathways
Apoptosis and survival TNFR1 signaling pathway59
TWEAK Signaling Pathway36
Apoptosis Modulation by HSP7036
HIV-1 Nef- Negative effector of Fas and TNF-alpha36
8.9TNFRSF11B, IL6, TNFSF11, TNF
258.9TNFRSF11B, TNF, TNFSF11, IL6
26
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway59
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB59
Development Angiopoietin Tie2 signaling59
8.8IL6, TIMP1, TNF, IL18R1
278.8IL11, TNF, IL1R1
288.8TNFSF11, CSF1, IL1R1, TNFRSF11B, TNF
29
Show member pathways
Apoptosis Modulation and Signaling36
Apoptosis36
8.7IL1R1, TNFRSF11B, TNF, IL1R2
308.7CSF1, TNF, MMP3, IL6, IL18R1
318.6TNF, IL6, IL1R1, IL1R2
32
Show member pathways
8.6IL1RN, IL6, IL1R1, IL1R2, IL6R
33
Show member pathways
8.6IL6R, IL1R1, IL1R2, IL1RN, IL6
34
Show member pathways
Transcription NF kB signaling pathway59
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response59
8.4IL6, IL1R1, IL11, TNF
358.4IL6, IL1R2, SERPINB2, IL1R1, TNF
36
Show member pathways
8.2IL1R2, TNF, TIMP1, IL1R1, IL6
37
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways59
Immune response IL 1 signaling pathway59
8.1IL1R1, IL6, TNF, IL18R1, IL1R2, IL1RN
387.8MMP3, TNF, TNFSF11, IL6, CSF1, IL11
39
Show member pathways
7.5TIMP1, IL6R, IL6, IL18R1, TNF, IL11
407.2TNF, IL11, IL1R1, IL1R2, IL6, CSF1
41
Show member pathways
6.9IL11, TIMP1, TNFSF11, TNF, IL18R1, IL6
42
Show member pathways
6.3TNF, TNFSF11, IL6R, IL11, IL1R1, IL1R2
43
Show member pathways
6.3TNFSF11, IL1R2, TIMP1, IL11, IL1R1, IL18R1
44
Show member pathways
6.0TNFSF11, TIMP1, IL11, IL1R2, IL18R1, IL1R1

Compounds for genes affiliated with Joint Disorders

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Compounds related to Joint Disorders according to GeneCards Suite gene sharing:

(show top 50)    (show all 213)
idCompoundScoreTop Affiliating Genes
1polymyxin b448.7IL1RN, TNFSF11, TNFRSF11B, IL6, TNF
2filgrastim44 119.6IL1RN, IL18R1, IL6, CSF1, IL11
3sulfasalazine28 44 50 1111.6TNF, MMP3, IL1R1, CSF1, IL1RN, IL1RAPL2
4anakinra44 119.5TNF, TNFRSF11B, IL6, IL1RN, IL1RAPL2, IL1R1
5adalimumab44 50 1110.5IL1R1, MMP3, IL6, IL1RN, IL1RAPL2, TNF
6ascorbic acid44 249.4MMP3, IL1R1, SERPINB2, TNFRSF11B, TNFSF11, CSF1
7deoxypyridinoline448.4IL6R, IL11, MMP3, TNFRSF11B, TNFSF11
8il 10448.3IL6, IL1RN, IL1RAPL2, IL1R1, TNF, IL6R
9ivig448.3TNF, IL1R1, IL6, IL18R1, IL1RN, IL1RAPL2
10neopterin448.0CSF1, IL6R, IL6, IL18R1, IL1RN, IL1RAPL2
11rosiglitazone28 44 50 24 1112.0CSF1, IL1RAPL2, IL6, IL1RN, IL1R1, TIMP1
12sb 20358044 608.9IL1R1, MMP3, TIMP1, TNFRSF11B, TNF, IL1RN
13creatinine447.7IL1RN, IL6, IL6R, TNFRSF11B, IL1RAPL2, IL1R1
14ribonucleic acid447.6IL6R, IL1RN, SERPINB2, IL1RAPL2, IL11, MMP3
15leflunomide44 50 119.6IL6, IL18R1, IL1RN, IL1RAPL2, IL1R1, MMP3
16leukotriene b444 60 249.6CSF1, IL6, IL1RN, IL1RAPL2, IL1R1, TNF
17genistein44 28 60 1 24 1112.6CSF1, TNF, TNFSF11, TNFRSF11B, TIMP1, MMP3
18testosterone44 60 24 1110.6IL6R, TNFRSF11B, IL1R1, IL1RAPL2, IL1RN, IL6
19vitamin d447.5IL6, TNFRSF11B, TNFSF11, TIMP1, IL1RN, IL1R1
20calcitriol44 60 24 1110.5TIMP1, TNFRSF11B, TNFSF11, TNF, IL18R1, IL6
21endotoxin447.5IL1R1, IL11, SERPINB2, TNF, IL1RN, IL18R1
2212-o-tetradecanoylphorbol 13-acetate447.5IL6R, IL18R1, TIMP1, CSF1, SERPINB2, MMP3
23prednisolone44 28 119.4CSF1, IL6R, IL6, IL18R1, IL1RN, IL1RAPL2
24progesterone44 28 60 24 1111.3MMP3, TIMP1, SERPINB2, TNFRSF11B, CSF1, IL6R
25thalidomide44 50 60 1110.3IL11, TNFRSF11B, TNF, IL1R1, IL18R1, IL6
26methotrexate50 44 119.3IL6R, IL6, IL1RN, IL1RAPL2, IL1R1, MMP3
27fibrinogen447.1IL1RAPL2, IL1RN, IL6R, TNFRSF11B, IL6, TNF
28lactate447.1CSF1, IL6, IL1RN, IL1RAPL2, IL1R1, TIMP1
29phosphatidylinositol447.1IL1RAPL2, TNFRSF11B, TIMP1, IL11, TNFSF11, IL1RN
30thymidine44 248.1CSF1, IL6R, IL6, IL18R1, IL1RAPL2, IL11
31gp 130447.0CSF1, IL6R, IL6, IL18R1, IL1RAPL2, IL1R1
32cysteine447.0COMT, TNFRSF11B, IL11, TIMP1, IL18R1, IL1RN
33tgf beta1447.0TNF, CSF1, IL6, IL1RN, IL1RAPL2, IL11
34histamine44 28 249.0TNF, CSF1, IL6R, IL1RN, IL1RAPL2, IL11
35rantes446.9IL18R1, IL1RN, IL1RAPL2, IL1R1, IL11, MMP3
36heparin44 28 24 119.9IL11, MMP3, SERPINB2, TIMP1, TNFRSF11B, TNFSF11
37nitric oxide44 24 118.5TIMP1, IL11, IL1R1, TNFRSF11B, TNF, IL1RAPL2
38infliximab44 50 118.5IL1R1, IL11, MMP3, TIMP1, TNFRSF11B, TNFSF11
39indomethacin44 28 60 119.4CSF1, TNF, TNFSF11, IL6, IL1RN, IL1RAPL2
40serine446.3TIMP1, SERPINB2, MMP3, IL11, IL1R1, TNFRSF11B
41etanercept44 50 118.2IL11, MMP3, TIMP1, TNFRSF11B, TNFSF11, TNF
42prostaglandin446.2IL18R1, IL1RN, IL1RAPL2, IL1R1, IL11, MMP3
43tyrosine446.2IL1R1, IL11, IL1RN, IL18R1, IL6, IL6R
44estrogen446.1TNFSF11, TNFRSF11B, TIMP1, SERPINB2, MMP3, IL11
45cyclosporin a44 28 608.0IL1RAPL2, IL1R1, IL11, MMP3, SERPINB2, TIMP1
46cycloheximide446.0IL6R, IL6, IL1RN, IL1RAPL2, IL1R1, IL11
47pge2445.7SERPINB2, TIMP1, TNFRSF11B, TNFSF11, TNF, MMP3
48vegf445.7IL18R1, IL6, IL6R, TIMP1, SERPINB2, MMP3
49retinoic acid44 246.5IL6R, COMT, CSF1, IL6, IL18R1, IL1RN
50dexamethasone44 50 28 118.1SERPINB2, CSF1, IL6R, IL6, IL18R1, IL1R2

GO Terms for genes affiliated with Joint Disorders

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Cellular components related to Joint Disorders according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1interleukin-6 receptor complexGO:00058969.5IL6, IL6R
2plasma membraneGO:00058867.4SERPINB2, IL1R1, IL1R2, IL1RN, IL18R1, IL6R
3extracellular spaceGO:00056156.7SERPINB2, TNFRSF11B, TNFSF11, TNF, MMP3, IL11
4extracellular regionGO:00055766.0IL6R, TNF, TNFSF11, TNFRSF11B, TIMP1, SERPINB2

Biological processes related to Joint Disorders according to GeneCards Suite gene sharing:

(show all 37)
idNameGO IDScoreTop Affiliating Genes
1osteoclast proliferationGO:000215810.3CSF1, TNFSF11
2hepatic immune responseGO:000238410.1IL6, IL6R
3negative regulation of collagen biosynthetic processGO:003296610.1IL6, IL6R
4chronic inflammatory response to antigenic stimulusGO:000243910.1IL1RN, TNF
5neutrophil mediated immunityGO:000244610.1IL6R, IL6
6interleukin-6-mediated signaling pathwayGO:007010210.0IL6, IL6R
7positive regulation of leukocyte chemotaxisGO:000269010.0IL6R, IL6
8monocyte chemotaxisGO:00025489.9IL6R, IL6, TNFSF11
9acute-phase responseGO:00069539.9IL6, IL6R, IL1RN
10positive regulation of osteoclast differentiationGO:00456729.8CSF1, TNFSF11, TNF
11osteoclast differentiationGO:00303169.8TNF, TNFSF11, CSF1
12positive regulation of NF-kappaB import into nucleusGO:00423469.8IL18R1, TNF
13negative regulation of lipid storageGO:00108889.8IL6, TNF
14epithelial cell proliferation involved in salivary gland morphogenesisGO:00606649.8TNF, IL6
15defense response to Gram-negative bacteriumGO:00508299.8IL6R, IL6
16tumor necrosis factor-mediated signaling pathwayGO:00332099.7TNF, TNFSF11
17positive regulation of tyrosine phosphorylation of Stat3 proteinGO:00425179.7IL6R, IL6
18positive regulation of chemokine productionGO:00327229.6IL6R, IL6, TNF
19defense response to Gram-positive bacteriumGO:00508309.6IL6R, TNF, IL6
20positive regulation of interleukin-6 productionGO:00327559.6IL6R, IL6, TNF
21positive regulation of smooth muscle cell proliferationGO:00486619.6IL6, IL6R, TNF
22positive regulation of protein kinase B signalingGO:00518979.6IL6, TNFSF11, TNF
23response to lipopolysaccharideGO:00324969.5IL6, COMT, IL1RN
24response to glucocorticoidGO:00513849.5IL6, IL1RN, TNF
25positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.5TNF, IL6, TNFSF11
26positive regulation of JUN kinase activityGO:00435079.4TNF, IL1RN
27positive regulation of NF-kappaB transcription factor activityGO:00510929.4IL6R, TNF, TNFSF11, IL6
28negative regulation of hormone secretionGO:00468889.4IL6, IL11
29positive regulation of MAPK cascadeGO:00434109.3IL6, IL11, IL6R
30negative regulation of apoptotic processGO:00430669.2TIMP1, SERPINB2, IL1RN, IL6
31positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.2IL11, IL6, IL6R
32immune responseGO:00069559.2IL1R1, IL1R2, IL1RN, IL18R1, TNFSF11
33extracellular matrix organizationGO:00301989.1TNFRSF11B, TIMP1, MMP3, TNF
34positive regulation of peptidyl-serine phosphorylationGO:00331389.0IL11, TNF, IL6
35response to drugGO:00424938.9IL6, TNFRSF11B, TNF, COMT, IL1RN
36cytokine-mediated signaling pathwayGO:00192218.8TNFSF11, IL1R2, IL1RAPL2, IL6, IL6R
37positive regulation of cell proliferationGO:00082848.6IL6R, TIMP1, IL11, IL6, CSF1

Molecular functions related to Joint Disorders according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:00051649.7TNFSF11, TNF
2interleukin-6 receptor bindingGO:00051389.7IL6, IL6R
3interleukin-1, Type II, blocking receptor activityGO:00049109.4IL1R2, IL1RAPL2
4protease bindingGO:00020209.2IL1R1, TIMP1, TNF
5interleukin-1 receptor activityGO:00049088.9IL18R1, IL1RAPL2, IL1R2, IL1R1
6growth factor activityGO:00080838.6CSF1, IL6, IL11
7cytokine activityGO:00051257.9TNF, TNFSF11, TNFRSF11B, IL11, IL6, CSF1

Sources for Joint Disorders

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet