MCID: JNT002
MIFTS: 51

Joint Disorders malady

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Summaries for Joint Disorders

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MedlinePlus:33 A joint is where two or more bones come together, like the knee, hip, elbow, or shoulder. joints can be damaged by many types of injuries or diseases, including arthritis - inflammation of a joint. it causes pain, stiffness, and swelling. over time, the joint can become severely damaged. bursitis - inflammation of a fluid-filled sac that cushions the joint dislocations - injuries that force the ends of the bones out of position treatment of joint problems depends on the cause. if you have a sports injury, treatment often begins with the rice (rest, ice, compression, and elevation) method to relieve pain, reduce swelling, and speed healing. other possible treatments include pain relievers, keeping the injured area from moving, rehabilitation, and sometimes surgery. for arthritis, injuries, or other diseases, you may need joint replacement surgery to remove the damaged joint and put in a new one. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards based summary: Joint Disorders is related to arthritis and psoriatic arthritis. An important gene associated with Joint Disorders is SERPINB2 (serpin peptidase inhibitor, clade B (ovalbumin), member 2), and among its related pathways are Osteoblast Signaling and Osteoclast Signaling. The compounds polymyxin b and filgrastim have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and brain, and related mouse phenotypes are craniofacial and tumorigenesis.

Wikipedia:65 An arthropathy is a disease of a joint. more...

Aliases & Classifications for Joint Disorders

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Related Diseases for Joint Disorders

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Diseases related to Joint Disorders via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 146)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis29.6MMP3, TIMP1, TNFSF11, TNF, IL6
2psoriatic arthritis29.4TNF, TNFSF11, IL1RAPL2, MMP3, TNFRSF11B
3juvenile rheumatoid arthritis29.0IL6, IL18R1, IL1R1, IL1RN, IL1RAPL2, TNF
4osteoarthritis27.8IL1RAPL2, IL1R1, IL1RN, IL6, CSF1, IL6R
5rheumatoid arthritis27.1IL18R1, IL1RN, IL1RAPL2, IL1R2, IL1R1, IL11
6periapical granuloma10.6TNFSF11
7dengue shock syndrome10.6IL1RN
8pigmented villonodular synovitis10.5CSF1
9hyper-igd syndrome10.5IL1RN
10periodontitis10.5TNFRSF11B
11cherubism10.5TNFSF11
12malignant histiocytosis10.5CSF1
13blau syndrome10.5TNF
14schnitzler syndrome10.4IL1R1, IL1RN
15pulpitis10.4TIMP1
16polyostotic osteolytic dysplasia, hereditary expansile10.4TNFRSF11B, TNFSF11
17paget disease, juvenile10.4TNFSF11, TNFRSF11B
18stomatitis10.4IL11
19megakaryocytic leukemia10.4IL11, IL6R
20giant cell tumor10.4TNFSF11, CSF1
21neisseria meningitidis infection10.4IL1R1, IL1RN
22alopecia areata10.4IL1RN, IL1R1
23malaria10.4TNF, IL18R1
24osteosclerosis10.3TNFRSF11B, TNFSF11
25aortic valve stenosis10.3TNFRSF11B, TNFSF11
26refractory anemia10.3IL11, CSF1
27lung giant cell carcinoma10.3IL6R, TIMP1
28conjunctivochalasis10.3MMP3, TIMP1
29hematologic cancer10.3IL11, CSF1, SERPINB2
30neutropenia10.3IL1RN, CSF1, IL11
31polymyalgia rheumatica10.3IL1RN, IL1RAPL2
32hodgkin's lymphoma10.3IL1RN, IL6R, IL18R1
33osteopetrosis10.3CSF1, TNFSF11, TNFRSF11B
34bone cancer10.3TNFSF11, CSF1, TNFRSF11B
35bronchopulmonary dysplasia10.2IL1RN, TIMP1
36beta thalassemia10.2TNFSF11, TNFRSF11B
37relapsing-remitting multiple sclerosis10.2TIMP1, IL1RN
38adult respiratory distress syndrome10.2TNF, IL1R1
39cholesteatoma10.2TNFRSF11B, TNFSF11, MMP3
40muckle-wells syndrome10.2IL1R1, IL1RAPL2
41gastritis10.2IL1RN, IL1RAPL2
42gingival overgrowth10.2TIMP1, MMP3
43acute graft versus host disease10.2IL1RN, IL1R1, TNF
44uveitis10.2TNF, IL1R1, IL18R1
45castleman's disease10.2IL6R, IL6
46multiple myeloma10.2TNFSF11, IL6
47sarcoma10.2IL18R1, IL1R1, SERPINB2, CSF1
48pancreatic cancer10.2IL1RN, SERPINB2, IL18R1, IL6R
49spondylarthropathy10.2TNF, IL1RAPL2
50kawasaki disease10.2MMP3, TIMP1

Graphical network of the top 20 diseases related to Joint Disorders:



Diseases related to joint disorders

Symptoms for Joint Disorders

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Drugs & Therapeutics for Joint Disorders

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Drug clinical trials:

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Search NIH Clinical Center for Joint Disorders

Cell-based therapeutics:


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Genetic Tests for Joint Disorders

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Anatomical Context for Joint Disorders

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MalaCards organs/tissues related to Joint Disorders:

32
Bone, Skin, Brain

Animal Models for Joint Disorders or affiliated genes

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Publications for Joint Disorders

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Articles related to Joint Disorders:

(show all 37)
idTitleAuthorsYear
1
Comparing proton density and turbo spin echo T2 weighted static sequences with dynamic half-Fourier single-shot TSE pulse sequence at 3.0a88T in diagnosis of temporomandibular joint disorders: a prospective study. (24720606)
2014
2
Cytopathologic diagnosis on joint lavage fluid for patients with temporomandibular joint disorders. (23904326)
2014
3
Pisotriquetral joint disorders: an under-recognized cause of ulnar side wrist pain. (24687844)
2014
4
Comprehensive treatment of temporomandibular joint disorders. (24660643)
2014
5
Signal intensity on fluid-attenuated inversion recovery images of condylar marrow changes correspond with slight pain in patients with temporomandibular joint disorders. (25177105)
2014
6
Brain signature of chronic orofacial pain: a systematic review and meta-analysis on neuroimaging research of trigeminal neuropathic pain and temporomandibular joint disorders. (24759798)
2014
7
Tibial tubercle osteotomy for patello-femoral joint disorders. (25326765)
2014
8
The use of low level laser therapy in the treatment of temporomandibular joint disorders. Review of the literature. (23722130)
2013
9
Oral splint for temporomandibular joint disorders with revolutionary fluid system. (24019797)
2013
10
Symptoms resembling temporomandibular joint disorder caused by a pleomorphic adenoma. (23763725)
2013
11
Arthrocentesis and temporomandibular joint disorders: clinical and radiological results of a prospective study. (24319462)
2013
12
Clinical-surgical treatment of temporomandibular joint disorder in a psoriatic arthritis patient. (23556553)
2013
13
Evaluation of Korean teenagers with temporomandibular joint disorders. (24471050)
2013
14
Clinical signs and symptoms of tinnitus in temporomandibular joint disorders: a pilot study comparing patients and non-patients. (25158368)
2013
15
CT Images of a Severe TMJ Osteoarthritis and Differential Diagnosis with Other Joint Disorders. (24381768)
2013
16
Surgical classification for temporomandibular joint disorders. (23787136)
2013
17
Evidence Based Approach for the Diagnosis of Temporomandibular Joint Disorders (TMD). (24431765)
2013
18
The importance of complementary exams for the diagnosis of temporomandibular joint disorders. (23768880)
2013
19
Response to letter to the editor by the American Society of Temporomandibular Joint Surgeons (ASTMJS) Re: G. Dimitroulis, a new surgical classification for temporomandibular joint disorders [Int. J. Oral Maxillofac. Surg. 42 (2013) 218-222]. (23773237)
2013
20
Intra-articular injections with corticosteroids and sodium hyaluronate for treating temporomandibular joint disorders: a systematic review. (24352399)
2013
21
WITHDRAWN: Hyaluronate for temporomandibular joint disorders. (24105378)
2013
22
Etiological factors of temporomandibular joint disorders. (23833510)
2012
23
Nasal obstruction may alleviate bruxism related temporomandibular joint disorders. (21041035)
2011
24
Increased levels of soluble cytokine receptors in the synovial fluid of temporomandibular joint disorders in relation to joint effusion on magnetic resonance images. (20149511)
2010
25
Assessing potential functionality of catechol-O-methyltransferase (COMT) polymorphisms associated with pain sensitivity and temporomandibular joint disorders. (20336436)
2010
26
Conservative care of temporomandibular joint disorder in a 35-year-old patient with spinal muscular atrophy type III: a case study. (19948309)
2009
27
Cutaneous events during treatment of chronic inflammatory joint disorders with anti-tumour necrosis factor alpha: a cross-sectional study. (18713230)
2008
28
Induction of osteoclast-like cells derived from the synovial lavage fluids of patients with temporomandibular joint disorders. (16979913)
2007
29
Gene therapy methods in bone and joint disorders. Evaluation of the adeno-associated virus vector in experimental models of articular cartilage disorders, periprosthetic osteolysis and bone healing. (17427340)
2007
30
Expression of receptor activator of nuclear factor-kappaB ligand in synovial tissue: comparison with degradation of articular cartilage in temporomandibular joint disorders. (17560137)
2007
31
Increase in RANKL: OPG ratio in synovia of patients with temporomandibular joint disorder. (16798863)
2006
32
Analysis of tumor necrosis factor-alpha, interleukin-6, interleukin-1beta, soluble tumor necrosis factor receptors I and II, interleukin-6 soluble receptor, interleukin-1 soluble receptor type II, interleukin-1 receptor antagonist, and protein in the synovial fluid of patients with temporomandibular joint disorders. (15716832)
2005
33
Interleukin-6 family of cytokines as biochemical markers of osseous changes in the temporomandibular joint disorders. (15121272)
2004
34
Expression of osteoprotegerin in synovial tissue and degradation of articular cartilage: comparison with arthroscopic findings of temporomandibular joint disorders. (12973279)
2003
35
Plasminogen activators and plasminogen activator inhibitors in synovial fluid. Difference between inflammatory joint disorders and osteoarthritis. (8441174)
1993
36
Ulnar variance in children--standard measurements for evaluation of ulnar shortening in juvenile rheumatoid arthritis, hereditary multiple exostosis and other bone or joint disorders in childhood. (2588029)
1989
37
Cervical spondylosis presenting as the facial pain of temporomandibular joint disorder. (5658372)
1968

Variations for Joint Disorders

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Expression for genes affiliated with Joint Disorders

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Expression patterns in normal tissues for genes affiliated with Joint Disorders

Search GEO for disease gene expression data for Joint Disorders.

Pathways for genes affiliated with Joint Disorders

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Pathways related to Joint Disorders according to GeneCards/GeneDecks:

(show all 44)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9TNFRSF11B, TNFSF11
29.9TNFSF11, TNFRSF11B
39.7TNF, CSF1
49.5IL6R, IL6, SERPINB2
59.5IL6, TNF
6
Show member pathways
9.5IL1R1, IL6, IL6R
79.4TNF, TNFSF11, IL1R1
8
Show member pathways
9.4TNF, TNFSF11, TNFRSF11B
9
Show member pathways
9.4TNF, TNFSF11, TNFRSF11B
109.3TIMP1, IL6, IL6R
11
Show member pathways
Serotonin Transporter Activity37
9.3IL1R1, TNFRSF11B, TNF
12
Show member pathways
IL-1 Signaling Pathway37
IL1-mediated signaling events37
9.3IL1RN, IL1R2, IL1R1
13
Show member pathways
9.3TNF, IL18R1, IL6
14
Show member pathways
IL27-mediated signaling events37
9.3TNF, IL18R1, IL6
159.2IL6R, IL6, TNF
16
Show member pathways
9.2TNF, TIMP1, MMP3
179.2CSF1, IL6, TNF
189.2TNF, IL1R1, IL6
19
Show member pathways
Immune response MIF in innate immunity response60
9.2IL6, IL1R1, TNF
209.1IL6R, IL6, TIMP1, TNFSF11
219.1IL6, IL1R2, MMP3
229.0TNF, IL1RN, IL6, IL6R
23
Show member pathways
Type III interferon signaling37
8.9IL6R, IL6, IL11
248.9TNF, TNFSF11, TNFRSF11B, IL6
25
Show member pathways
Apoptosis and survival TNFR1 signaling pathway60
TWEAK Signaling Pathway37
Apoptosis Modulation by HSP7037
HIV-1 Nef- Negative effector of Fas and TNF-alpha37
8.9TNF, TNFSF11, TNFRSF11B, IL6
26
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
8.8TNF, TIMP1, IL18R1, IL6
278.8IL1R1, IL11, TNF
288.8TNF, TNFSF11, TNFRSF11B, IL1R1, CSF1
29
Show member pathways
Apoptosis Modulation and Signaling37
Apoptosis37
8.7TNF, TNFRSF11B, IL1R1, IL1R2
308.7CSF1, IL6, IL18R1, MMP3, TNF
318.6IL6, IL1R2, IL1R1, TNF
32
Show member pathways
8.6IL1R1, IL1R2, IL1RN, IL6, IL6R
33
Show member pathways
8.6IL1R1, IL1R2, IL1RN, IL6, IL6R
34
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
8.4IL6, IL1R1, IL11, TNF
358.4TNF, SERPINB2, IL1R1, IL1R2, IL6
36
Show member pathways
8.2TNF, TIMP1, IL1R1, IL1R2, IL6
37
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
8.1TNF, IL1R1, IL1R2, IL1RN, IL18R1, IL6
387.8TNF, TNFSF11, MMP3, IL11, IL6, CSF1
39
Show member pathways
7.5TNF, TIMP1, IL11, IL1R1, IL18R1, IL6
407.2TNF, IL11, IL1R1, IL1R2, IL6, IL6R
41
Show member pathways
6.9TNF, TNFSF11, TIMP1, IL11, IL1R1, IL18R1
42
Show member pathways
6.3TNF, TNFSF11, TIMP1, IL11, IL1R1, IL1R2
43
Show member pathways
6.3TNF, TNFSF11, TIMP1, IL11, IL1R1, IL1R2
44
Show member pathways
6.0CSF1, TNF, TNFSF11, TNFRSF11B, TIMP1, IL11

Compounds for genes affiliated with Joint Disorders

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Compounds related to Joint Disorders according to GeneCards/GeneDecks:

(show top 50)    (show all 213)
idCompoundScoreTop Affiliating Genes
1polymyxin b448.7IL1RN, TNFSF11, TNFRSF11B, IL6, TNF
2filgrastim44 119.6IL1RN, IL18R1, IL6, CSF1, IL11
3sulfasalazine28 44 50 1111.6TNF, MMP3, IL1R1, CSF1, IL1RN, IL1RAPL2
4anakinra44 119.5TNF, TNFRSF11B, IL6, IL1RN, IL1RAPL2, IL1R1
5adalimumab44 50 1110.5IL1R1, MMP3, IL6, IL1RN, IL1RAPL2, TNF
6ascorbic acid44 249.4MMP3, IL1R1, SERPINB2, TNFRSF11B, TNFSF11, CSF1
7deoxypyridinoline448.4IL6R, IL11, MMP3, TNFRSF11B, TNFSF11
8il 10448.3IL6, IL1RN, IL1RAPL2, IL1R1, TNF, IL6R
9ivig448.3TNF, IL1R1, IL6, IL18R1, IL1RN, IL1RAPL2
10neopterin448.0CSF1, IL6R, IL6, IL18R1, IL1RN, IL1RAPL2
11rosiglitazone28 44 50 24 1112.0CSF1, IL1RAPL2, IL6, IL1RN, IL1R1, TIMP1
12sb 20358044 618.9IL1R1, MMP3, TIMP1, TNFRSF11B, TNF, IL1RN
13creatinine447.7IL1RN, IL6, IL6R, TNFRSF11B, IL1RAPL2, IL1R1
14ribonucleic acid447.6IL6R, IL1RN, SERPINB2, IL1RAPL2, IL11, MMP3
15leflunomide44 50 119.6IL6, IL18R1, IL1RN, IL1RAPL2, IL1R1, MMP3
16leukotriene b444 61 249.6CSF1, IL6, IL1RN, IL1RAPL2, IL1R1, TNF
17genistein44 28 61 2 24 1112.6CSF1, TNF, TNFSF11, TNFRSF11B, TIMP1, MMP3
18testosterone44 61 24 1110.6IL6R, TNFRSF11B, IL1R1, IL1RAPL2, IL1RN, IL6
19vitamin d447.5IL6, TNFRSF11B, TNFSF11, TIMP1, IL1RN, IL1R1
20calcitriol44 61 24 1110.5TIMP1, TNFRSF11B, TNFSF11, TNF, IL18R1, IL6
21endotoxin447.5IL1R1, IL11, SERPINB2, TNF, IL1RN, IL18R1
2212-o-tetradecanoylphorbol 13-acetate447.5IL6R, IL18R1, TIMP1, CSF1, SERPINB2, MMP3
23prednisolone44 28 119.4CSF1, IL6R, IL6, IL18R1, IL1RN, IL1RAPL2
24progesterone44 28 61 24 1111.3MMP3, TIMP1, SERPINB2, TNFRSF11B, CSF1, IL6R
25thalidomide44 50 61 1110.3IL11, TNFRSF11B, TNF, IL1R1, IL18R1, IL6
26methotrexate50 44 119.3IL6R, IL6, IL1RN, IL1RAPL2, IL1R1, MMP3
27fibrinogen447.1IL1RAPL2, IL1RN, IL6R, TNFRSF11B, IL6, TNF
28lactate447.1CSF1, IL6, IL1RN, IL1RAPL2, IL1R1, TIMP1
29phosphatidylinositol447.1IL1RAPL2, TNFRSF11B, TIMP1, IL11, TNFSF11, IL1RN
30thymidine44 248.1CSF1, IL6R, IL6, IL18R1, IL1RAPL2, IL11
31gp 130447.0CSF1, IL6R, IL6, IL18R1, IL1RAPL2, IL1R1
32cysteine447.0COMT, TNFRSF11B, IL11, TIMP1, IL18R1, IL1RN
33tgf beta1447.0TNF, CSF1, IL6, IL1RN, IL1RAPL2, IL11
34histamine44 28 249.0TNF, CSF1, IL6R, IL1RN, IL1RAPL2, IL11
35rantes446.9IL18R1, IL1RN, IL1RAPL2, IL1R1, IL11, MMP3
36heparin44 28 24 119.9IL11, MMP3, SERPINB2, TIMP1, TNFRSF11B, TNFSF11
37nitric oxide44 24 118.5TIMP1, IL11, IL1R1, TNFRSF11B, TNF, IL1RAPL2
38infliximab44 50 118.5IL1R1, IL11, MMP3, TIMP1, TNFRSF11B, TNFSF11
39indomethacin44 28 61 119.4CSF1, TNF, TNFSF11, IL6, IL1RN, IL1RAPL2
40serine446.3TIMP1, SERPINB2, MMP3, IL11, IL1R1, TNFRSF11B
41etanercept44 50 118.2IL11, MMP3, TIMP1, TNFRSF11B, TNFSF11, TNF
42prostaglandin446.2IL18R1, IL1RN, IL1RAPL2, IL1R1, IL11, MMP3
43tyrosine446.2IL1R1, IL11, IL1RN, IL18R1, IL6, IL6R
44estrogen446.1TNFSF11, TNFRSF11B, TIMP1, SERPINB2, MMP3, IL11
45cyclosporin a44 28 618.0IL1RAPL2, IL1R1, IL11, MMP3, SERPINB2, TIMP1
46cycloheximide446.0IL6R, IL6, IL1RN, IL1RAPL2, IL1R1, IL11
47pge2445.7SERPINB2, TIMP1, TNFRSF11B, TNFSF11, TNF, MMP3
48vegf445.7IL18R1, IL6, IL6R, TIMP1, SERPINB2, MMP3
49retinoic acid44 246.5IL6R, COMT, CSF1, IL6, IL18R1, IL1RN
50dexamethasone44 50 28 118.1SERPINB2, CSF1, IL6R, IL6, IL18R1, IL1R2

GO Terms for genes affiliated with Joint Disorders

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Cellular components related to Joint Disorders according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-6 receptor complexGO:0058969.5IL6, IL6R
2plasma membraneGO:0058867.4SERPINB2, IL1R1, IL1R2, IL1RN, IL18R1, IL6R
3extracellular spaceGO:0056156.7SERPINB2, TNFRSF11B, TNFSF11, TNF, MMP3, IL11
4extracellular regionGO:0055766.0IL6R, TNF, TNFSF11, TNFRSF11B, TIMP1, SERPINB2

Biological processes related to Joint Disorders according to GeneCards/GeneDecks:

(show all 37)
idNameGO IDScoreTop Affiliating Genes
1osteoclast proliferationGO:00215810.3TNFSF11, CSF1
2hepatic immune responseGO:00238410.1IL6, IL6R
3negative regulation of collagen biosynthetic processGO:03296610.1IL6R, IL6
4chronic inflammatory response to antigenic stimulusGO:00243910.1TNF, IL1RN
5neutrophil mediated immunityGO:00244610.1IL6R, IL6
6interleukin-6-mediated signaling pathwayGO:07010210.0IL6R, IL6
7monocyte chemotaxisGO:0025489.9IL6R, IL6, TNFSF11
8positive regulation of leukocyte chemotaxisGO:0026909.9IL6, IL6R
9acute-phase responseGO:0069539.9IL6R, IL6, IL1RN
10positive regulation of osteoclast differentiationGO:0456729.8TNF, TNFSF11, CSF1
11osteoclast differentiationGO:0303169.8CSF1, TNFSF11, TNF
12positive regulation of NF-kappaB import into nucleusGO:0423469.8IL18R1, TNF
13epithelial cell proliferation involved in salivary gland morphogenesisGO:0606649.8TNF, IL6
14negative regulation of lipid storageGO:0108889.8TNF, IL6
15defense response to Gram-negative bacteriumGO:0508299.8IL6R, IL6
16tumor necrosis factor-mediated signaling pathwayGO:0332099.7TNFSF11, TNF
17positive regulation of chemokine productionGO:0327229.6TNF, IL6, IL6R
18defense response to Gram-positive bacteriumGO:0508309.6IL6R, IL6, TNF
19positive regulation of JUN kinase activityGO:0435079.6TNF, IL1RN
20positive regulation of interleukin-6 productionGO:0327559.6TNF, IL6, IL6R
21positive regulation of smooth muscle cell proliferationGO:0486619.6IL6R, IL6, TNF
22positive regulation of protein kinase B signalingGO:0518979.6TNF, TNFSF11, IL6
23response to lipopolysaccharideGO:0324969.5COMT, IL6, IL1RN
24response to glucocorticoidGO:0513849.5IL6, IL1RN, TNF
25positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.5IL6, TNFSF11, TNF
26positive regulation of tyrosine phosphorylation of Stat3 proteinGO:0425179.5IL6, IL6R
27negative regulation of hormone secretionGO:0468889.4IL11, IL6
28positive regulation of NF-kappaB transcription factor activityGO:0510929.4IL6R, IL6, TNFSF11, TNF
29positive regulation of MAPK cascadeGO:0434109.3IL11, IL6, IL6R
30negative regulation of apoptotic processGO:0430669.2TIMP1, SERPINB2, IL1RN, IL6
31positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.2IL6R, IL6, IL11
32immune responseGO:0069559.2TNFSF11, IL1R1, IL1R2, IL1RN, IL18R1
33extracellular matrix organizationGO:0301989.1TNF, TNFRSF11B, TIMP1, MMP3
34positive regulation of peptidyl-serine phosphorylationGO:0331389.0IL6, IL11, TNF
35response to drugGO:0424938.9TNF, TNFRSF11B, IL1RN, IL6, COMT
36cytokine-mediated signaling pathwayGO:0192218.8IL6R, IL6, IL1RAPL2, IL1R2, TNFSF11
37positive regulation of cell proliferationGO:0082848.6TIMP1, IL11, IL6, IL6R, CSF1

Molecular functions related to Joint Disorders according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:0051649.7TNF, TNFSF11
2interleukin-6 receptor bindingGO:0051389.7IL6R, IL6
3interleukin-1, Type II, blocking receptor activityGO:0049109.4IL1RAPL2, IL1R2
4protease bindingGO:0020209.2IL1R1, TNF, TIMP1
5interleukin-1 receptor activityGO:0049088.9IL1R1, IL18R1, IL1RAPL2, IL1R2
6growth factor activityGO:0080838.6IL6, CSF1, IL11
7cytokine activityGO:0051257.9IL6, CSF1, IL11, TNFSF11, TNF, TNFRSF11B

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25ICD10
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27ICD9CM
28IUPHAR
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