Aliases & Classifications for Joint Disorders

MalaCards integrated aliases for Joint Disorders:

Name: Joint Disorders 38 41
Arthropathy 69

Summaries for Joint Disorders

MedlinePlus : 41 a joint is where two or more bones come together, like the knee, hip, elbow, or shoulder. joints can be damaged by many types of injuries or diseases, including arthritis - inflammation of a joint. it causes pain, stiffness, and swelling. over time, the joint can become severely damaged. bursitis - inflammation of a fluid-filled sac that cushions the joint dislocations - injuries that force the ends of the bones out of position treatment of joint problems depends on the cause. if you have a sports injury, treatment often begins with the rice (rest, ice, compression, and elevation) method to relieve pain, reduce swelling, and speed healing. other possible treatments include pain relievers, keeping the injured area from moving, rehabilitation, and sometimes surgery. for arthritis, injuries, or other diseases, you may need joint replacement surgery to remove the damaged joint and put in a new one. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards based summary : Joint Disorders, also known as arthropathy, is related to crystal arthropathies and spondylosis, and has symptoms including arthralgia, back pain and metatarsalgia. An important gene associated with Joint Disorders is IL6 (Interleukin 6), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Etanercept and Hyaluronic acid have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and bone marrow, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and hematopoietic system

Wikipedia : 72 An arthropathy is a disease of a joint.Arthritis is a form of arthropathy that involves inflammation of... more...

Related Diseases for Joint Disorders

Diseases related to Joint Disorders via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 191)
id Related Disease Score Top Affiliating Genes
1 crystal arthropathies 31.3 IL1R1 IL1RN IL6
2 spondylosis 29.1 IL1B IL1R1 IL6
3 rheumatoid arthritis 26.2 CSF1 IL11 IL17A IL1B IL1R1 IL1RN
4 smarca4-deficient sarcoma of thorax 10.9 IL6 TNF
5 aortic arch interruption 10.8 IL6 TNF
6 cutaneous leishmaniasis 10.7 IL6 TNF
7 alcohol abuse 10.7 IL6 SERPINB2 TNF
8 residual stage corticosteroid-induced glaucoma 10.7 IL6 MMP3 TNF
9 tricho onychic dysplasia 10.6 IL17A IL6 TNF
10 shoulder impingement syndrome 10.6 IL1RN IL6
11 early congenital syphilis 10.6 IL1RN IL6 TNF
12 tracheal stenosis 10.6 IL17A IL6 TNF
13 gait apraxia 10.6 MMP3 PLAU TIMP1
14 cytomegalovirus disease in patients with impaired cell mediated immunity deemed at risk 10.6 IL17A IL6 TNF
15 gastroduodenal crohn's disease 10.6 IL17A IL6 TNF
16 nervous system cancer 10.6 IL6 MMP3 TIMP1
17 vagina leiomyosarcoma 10.6 IL1RN IL6 MMP3
18 esophagus melanoma 10.6 IL1RN IL6 TNF
19 c1 inhibitor deficiency 10.6 IL17A IL6 TNF
20 disease of mental health 10.6 IL17A IL6 TNF
21 emphysema, congenital lobar 10.6 IL6 MMP3 TNF
22 cornea cancer 10.6 IL17A IL6 TNF
23 lung disease 10.6 IL17A MMP3 TNF
24 spirillary rat-bite fever 10.6 IL6 TNF
25 primary biliary cirrhosis 10.6 IL1R1 IL6 TNF
26 septicemic plague 10.6 PLAU TNF TNFSF11
27 muscle tissue disease 10.5 IL17A IL6 TNF
28 oculomotor nerve paralysis 10.5 IL1B IL6
29 toxoplasmosis 10.5 IL6 TNF
30 tabatznik syndrome 10.5 IL1B TNF
31 common peroneal nerve lesion 10.5 IL1B IL6
32 cortical blindness 10.5 CSF1 TNFSF11
33 diamond-blackfan anemia 1 10.5 IL6 MMP3 TIMP1 TNF
34 sternal cleft 10.5 IL1B TNF
35 scrotal carcinoma 10.5 IL1B IL6 TNF
36 upper gum cancer 10.4 IL1B IL6 TNF
37 bipolar i disorder 10.4 IL1B IL6 TNF
38 tinea favosa 10.4 IL1B IL6 TNF
39 pancreatic acth hormone producing tumor 10.4 IL6 MMP3 PLAU TIMP1
40 early-onset zonular cataract 10.4 IL1B IL6 TNF
41 burn scar 10.4 IL17A IL6 TIMP1 TNF
42 acquired thrombocytopenia 10.4 IL1B IL6 TNF
43 ampulla of vater neoplasm 10.4 IL1B IL6 TNF
44 brucella canis brucellosis 10.4 IL1B IL6 TNF
45 foodborne botulism 10.4 IL1B IL6 TNF
46 neonatal jaundice 10.4 IL17A IL6 TIMP1 TNF
47 ovarian mucinous adenofibroma 10.4 IL1B IL6 TNF
48 myeloid sarcoma 10.4 IL1B IL6 TNF
49 human monocytic ehrlichiosis 10.4 IL1B IL6 TNF
50 cholera 10.4 IL1B IL6 TIMP1

Graphical network of the top 20 diseases related to Joint Disorders:



Diseases related to Joint Disorders

Symptoms & Phenotypes for Joint Disorders

UMLS symptoms related to Joint Disorders:


arthralgia, back pain, metatarsalgia, muscle cramp, sciatica, joint swelling, other symptoms referable to joint, other symptoms referable to joint, shoulder region, other symptoms referable to joint, upper arm, other symptoms referable to joint, forearm, other symptoms referable to joint, hand, other symptoms referable to joint, pelvic region and thigh, other symptoms referable to joint, lower leg, other symptoms referable to joint, ankle and foot, other symptoms referable to joint, other specified sites, other symptoms referable to joint, multiple sites, joint stiffness, musculoskeletal symptom, other symptoms referable to joint, site unspecified, joint symptom, stiffness of joint, not elsewhere classified in icd10cm

GenomeRNAi Phenotypes related to Joint Disorders according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-116 9.55 CSF1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-142 9.55 CSF1 TNFSF11
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.55 TNFSF11
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 9.55 IL1RN
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-175 9.55 TNFSF11
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.55 CSF1 IL18R1 IL1RN PLAU TNFSF11
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.55 PLAU
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.55 IL18R1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-75 9.55 PLAU
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.55 CSF1
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.55 CSF1 TNFSF11

MGI Mouse Phenotypes related to Joint Disorders:

44 (show all 11)
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.28 CSF1 IL17A IL18R1 IL1B IL1R1 IL1RN
2 homeostasis/metabolism MP:0005376 10.25 CSF1 DKK1 IL17A IL1B IL1R1 IL1RN
3 growth/size/body region MP:0005378 10.23 DKK1 IL17A IL1R1 IL1RN IL6 IL6R
4 immune system MP:0005387 10.21 IL1RN IL6 IL6R MMP3 PLAU SERPINB2
5 endocrine/exocrine gland MP:0005379 10.13 CSF1 IL17A IL1R1 IL6 IL6R PLAU
6 mortality/aging MP:0010768 10.13 CSF1 DKK1 IL17A IL1B IL1R1 IL1RN
7 craniofacial MP:0005382 10.04 CSF1 DKK1 IL17A IL1R1 PLAU TNF
8 muscle MP:0005369 9.8 IL6 PLAU SERPINB2 TNF TNFSF11 CSF1
9 neoplasm MP:0002006 9.76 IL1B IL1R1 IL6 IL6R PLAU TIMP1
10 respiratory system MP:0005388 9.61 CSF1 DKK1 IL17A IL1R1 IL6 PLAU
11 skeleton MP:0005390 9.4 CSF1 DKK1 IL17A IL1B IL1R1 IL1RN

Drugs & Therapeutics for Joint Disorders

Drugs for Joint Disorders (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 905)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etanercept Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 185243-69-0
2
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 9004-61-9 53477741 24759
3
Azithromycin Approved Phase 4,Phase 3 83905-01-5 55185 53477736 447043
4
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 53-03-2 5865
5
Thrombin Approved Phase 4
6
Bevacizumab Approved, Investigational Phase 4 216974-75-3
7
Acetaminophen Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 103-90-2 1983
8
Tranexamic Acid Approved Phase 4,Phase 3,Phase 2,Phase 1 1197-18-8 5526
9
Milnacipran Approved Phase 4 92623-85-3 65833
10
Norepinephrine Approved Phase 4,Phase 3,Phase 1,Phase 2 51-41-2 439260
11
Rivaroxaban Approved Phase 4,Phase 2,Phase 3 366789-02-8
12
Tranylcypromine Approved Phase 4 155-09-9 441233
13
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-02-2 5743
14
Ropivacaine Approved Phase 4,Phase 2,Phase 3 84057-95-4 71273 175805
15
Iron Approved Phase 4,Phase 1,Phase 2 7439-89-6 23925
16
Celecoxib Approved, Investigational Phase 4,Phase 3,Phase 2 169590-42-5 2662
17
Esomeprazole Approved, Investigational Phase 4,Phase 3,Phase 1 161796-78-7, 119141-88-7 4594 9579578
18
Naproxen Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 22204-53-1 1302 156391
19
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
20
Denosumab Approved Phase 4,Phase 3,Phase 2,Phase 1 615258-40-7
21
Cimetidine Approved Phase 4,Phase 3,Phase 2 51481-61-9 2756
22
Hyoscyamine Approved Phase 4 101-31-5 64692
23
Hydroxychloroquine Approved Phase 4,Phase 3,Phase 2 118-42-3 3652
24
Infliximab Approved Phase 4,Phase 3,Phase 2,Phase 1 170277-31-3
25
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 1959-05-2, 59-05-2 126941
26
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 83-43-2 6741
27
Naltrexone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 16590-41-3 5360515
28
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 50-24-8 5755
29
Sulfasalazine Approved Phase 4,Phase 2,Phase 3,Phase 1 599-79-1 5353980 5359476
30
Leflunomide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 75706-12-6 3899
31
Menthol Approved Phase 4,Phase 3,Phase 2,Early Phase 1 2216-51-5 16666
32
Anastrozole Approved, Investigational Phase 4,Phase 2 120511-73-1 2187
33
Letrozole Approved, Investigational Phase 4,Phase 2 112809-51-5 3902
34
Adalimumab Approved Phase 4,Phase 3,Phase 2,Phase 1 331731-18-1 16219006
35
Diclofenac Approved, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 15307-86-5 3033
36
Etoricoxib Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 202409-33-4 123619
37
Abatacept Approved Phase 4,Phase 3,Phase 2,Phase 1 332348-12-6 10237
38
rituximab Approved Phase 4,Phase 2,Phase 3,Phase 1 174722-31-7 10201696
39
Certolizumab pegol Approved Phase 4,Phase 3,Phase 2,Phase 1 428863-50-7
40
Epinephrine Approved, Vet_approved Phase 4,Phase 2,Phase 3 51-43-4 5816
41
Ketorolac Approved Phase 4,Phase 3,Phase 2 74103-06-3, 66635-83-4 3826
42
Morphine Approved, Investigational Phase 4,Phase 3,Phase 2 57-27-2 5288826
43 Racepinephrine Approved Phase 4,Phase 2,Phase 3
44
Calcium Carbonate Approved Phase 4,Phase 3,Phase 2 471-34-1
45
Cyclophosphamide Approved, Investigational Phase 4,Phase 2,Phase 1 50-18-0, 6055-19-2 2907
46
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 22916-47-8 4189
47
Pamidronate Approved Phase 4 40391-99-9 4674
48
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 124-94-7 31307
49
Bupivacaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 2180-92-9, 38396-39-3 2474
50
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 137-58-6 3676

Interventional clinical trials:

(show top 50) (show all 6570)

id Name Status NCT ID Phase Drugs
1 Targeting Synovitis in Early Rheumatoid Arthritis Unknown status NCT00920478 Phase 4
2 Hyaluronan Versus NaCl 20 Ml Versus Placebo in Knee Osteoarthritis Unknown status NCT00144820 Phase 4 Injection of Hyaluronan or Saline
3 The Efficacy of Prednisone and Azithromycin in the Treatment of Patients With Cat Scratch Disease Unknown status NCT01469702 Phase 4 prednison and azithromycin;prednison, azithromycin;prednison, Azenil
4 The Effect of Biannual Monitoring With Magnetic Resonance Imaging (MRI), X-ray, or Usual Care on Treatment for Inflammatory Arthritis Unknown status NCT00808496 Phase 4
5 Subclinical Joint Bleeding in Irish Adults With Severe Haemophilia A on Personalised Prophylaxis Regimens Unknown status NCT02314325 Phase 4 ADVATE [Antihemophilic Factor (Recombinant)];ADVATE [Antihemophilic Factor (Recombinant)]
6 Birmingham Hip Resurfacing (BHR) Study: Implantation of a Hip Resurfacing Endoprosthesis Unknown status NCT00180206 Phase 4
7 Oral Versus Intravenous Antibiotics for Bone and Joint Infections (OVIVA B&J) Unknown status NCT00974493 Phase 4 Antibiotics
8 Evicel Study on the Peri-operative Bleeding in Total Knee Prothesis Surgery Unknown status NCT00983112 Phase 4 Human Fibrinogen and human thrombin (Evicel);Sodium Chlorure (Physiological saline)
9 Validation of a Stress Device for the Knee Unknown status NCT02444663 Phase 4
10 The Effect of Intraaricular Knee Injections of Hyaluronic Acid (HA) on Bone and Cartilaginous Debris, as a Therapeutic Indicator Unknown status NCT00422643 Phase 4 Sodium hyaluronate (hyaluronic acid)
11 Intra-articular Bevacizumab for Recurrent Hemarthroses at Target Joints With Chronic Hemophilic Synovitis Unknown status NCT02060305 Phase 4 Bevacizumab intra-articular injection
12 Close Kinect Chain Exercise With Kinesio Taping in the Management of Patellofemoral Pain Syndrome Unknown status NCT02241148 Phase 4 Acetaminophen 500mg
13 Roentgen Stereophotogrammetric Analysis (RSA) Trial Comparing Trabecular Metal Monoblock and Modular Tibial Components Unknown status NCT01180595 Phase 4
14 Tranexamic Acid in Knee Joint Surgery Unknown status NCT02278263 Phase 4 Tranexamic Acid;Normal saline (0.9% NaCl)
15 A Randomized Controlled Trial of Long Versus Short Wait For Primary Total Hip and Knee Arthroplasty Unknown status NCT00138892 Phase 4
16 Hip Viscosupplementation: What is the Best Dosage? Unknown status NCT01810809 Phase 4 1 ampoule of Hylan GF-20;2 ampoules of Hylan GF-20;3 ampoules of Hylan GF-20
17 Study to Evaluate the Efficacy of Milnacipran in the Treatment of Pain Due to Osteoarthritis Unknown status NCT01329406 Phase 4 Milnacipran;Placebo
18 Outcome Comparison of Allograft and Synthetic Bone Substitute in High Tibial Osteotomy Unknown status NCT02000297 Phase 4
19 Reinflation After Early Tourniquet Release in Total Knee Arthroplasty Unknown status NCT01832272 Phase 4
20 Effectiveness Study of Hylan G-F 20 to Preserve Cartilage in Osteoarthritis of the Knee Unknown status NCT00393393 Phase 4 intra-articular injection of Hylan G-F 20
21 Multi-center Clinical Study of Guli Capsules in the Treatment of Knee Osteoarthritis Unknown status NCT02484508 Phase 4 Guli capsule;Kangguzengsheng capsule
22 Medical Chitosan or Sodium Hyaluronate for Knee Osteoarthritis (CHOOSE) Unknown status NCT02323451 Phase 4 Sodium Hyaluronate Injection
23 The Impact of Hyaluronic Acid Injections on Osteoarthritic Knee Mechanics Unknown status NCT00778076 Phase 4
24 Comparison of Topical and Infusion Tranexamic Acid After Total Knee Arthroplasty Unknown status NCT02453802 Phase 4 Tranexamic Acid 5%,5ml/amp;Tranexamic Acid 5%,5ml/amp;rivaroxaban (10mg);0.9% Normal Saline;0.9% Normal Saline
25 Trial Comparing Navigated and Conventional Implantation Techniques in Knee Replacement Surgery Unknown status NCT00431509 Phase 4
26 Comparison of Floseal® and Tranexamic Acid on Bleeding Control After Total Knee Arthroplasty Unknown status NCT02152917 Phase 4 Tranexamic acid;Floseal®
27 Comparison of Femoral Nerve Catheter and Adductor Canal Block With Steroid Adjuvant in Total Knee Replacement (TKR) Unknown status NCT01973530 Phase 4
28 Chondroitin Sulphate Treatment Efficacy in Rhizarthrosis. Unknown status NCT01233739 Phase 4 Chondroitin sulfate;Placebo
29 Intravenous Iron Sucrose in Arthroplasty Unknown status NCT02544828 Phase 4 Iron Sucrose 200mg;placebo
30 The Post-marketing Surveillance to Evaluate the Efficacy of CHONDRON (Autologous Cultured Chondrocyte) by Arthroscopy Unknown status NCT02539069 Phase 4
31 The Post-marketing Surveillance to Evaluate the Efficacy and Safety of a CHONDRON (Autologous Cultured Chondrocyte) Unknown status NCT02539056 Phase 4
32 Gastro-protective Effect and Pain Relief Effect of Naxozol Compared to Celecoxib in Patients With Osteoarthritis Unknown status NCT02355236 Phase 4 Naproxen/Esomeprazol 500/20mg;Celecoxib 200mg;Naxozol-Placebo;Comparator-Placebo
33 Intraarticular Xylitol Injections for Knee Osteoarthritis Unknown status NCT02104596 Phase 4
34 The Effect of Spironolactone on Pain in Older People With Osteoarthritis Unknown status NCT02046668 Phase 4 spironolactone
35 A Phase 4 Study of Imrecoxib in Treatment of Knee Osteoarthritis Unknown status NCT01985165 Phase 4 Imrecoxib
36 Denosumab in Enhancement of Bone Bonding of Hip Prosthesis in Postmenopausal Women Unknown status NCT01926158 Phase 4 Denosumb;Placebo (for denosumab)
37 Bone Forming at Prosthetic Surfaces. Fingerprint2 Unknown status NCT01623687 Phase 4
38 RSA Study Using Two Types of Uncemented Acetabular Components and the Uncemented HA Coated Symax Stem Unknown status NCT01618084 Phase 4
39 Assessment of the Effects of Chondroitin Sulphate in Patients With Knee Osteoarthritis With Functional Magnetic Resonance Imaging (fMRI) Unknown status NCT01226615 Phase 4 Chondroitin sulphate (Condrosan®);Placebo
40 Comparison of Outcomes in Mobile and Fixed-bearing Total Knee Arthroplasty Unknown status NCT01027819 Phase 4
41 Use of Cold and Compression Therapy With Total Knee Replacement Patients Unknown status NCT00712816 Phase 4
42 Effect of Flex-a-New on Osteoarthritis of the Knee Unknown status NCT00294801 Phase 4 flex-a-new (food supplement)
43 Comparing Clinical Outcome of 2 Different Total Knee Prostheses: Nexgen LPS-Flex Versus AGC Unknown status NCT00294528 Phase 4
44 Efficacy of Celecoxib Vs Placebo to Prevent Pain in a Paced Walk Unknown status NCT00194090 Phase 4 celecoxib
45 RFN for SIJ Disease Study Unknown status NCT01726608 Phase 4
46 The Long-term Evaluation of Glucosamine Sulphate Study Unknown status NCT00513422 Phase 4
47 Comparison of Efficacy and Safety of Microfracture and Modified Microfracture Unknown status NCT02539030 Phase 4
48 Bipolar Sealer Aquamantys Use in Total Knee Replacement Unknown status NCT01736644 Phase 4
49 Comparison Between Anterior and Direct Lateral Approach in Total Hip Arthroplasty Unknown status NCT01578746 Phase 4
50 Rheumatoid Arthritis Patients in Training Unknown status NCT00434200 Phase 4

Search NIH Clinical Center for Joint Disorders

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Joint Disorders cell therapies at LifeMap Discovery.

Genetic Tests for Joint Disorders

Anatomical Context for Joint Disorders

MalaCards organs/tissues related to Joint Disorders:

39
Bone, Testes, Bone Marrow, Eye, Breast, Skin, Endothelial

Publications for Joint Disorders

Articles related to Joint Disorders:

(show top 50) (show all 96)
id Title Authors Year
1
The association between condylar bone changes revealed in cone beam computed tomography and clinical dysfunction index in patients with or without temporomandibular joint disorders. ( 28256415 )
2017
2
Treatment of Temporomandibular Joint Disorders: The Unwanted Stepchild. ( 28667833 )
2017
3
Temporomandibular Joint Disorders as a Cause of Aural Fullness. ( 28103655 )
2017
4
Association between composites of selected motion palpation and pain provocation tests for sacroiliac joint disorders. ( 28532864 )
2017
5
An Analysis of Pathological Activities of CCN Proteins in Joint Disorders: Mechanical Stretch-Mediated CCN2 Expression in Cultured Meniscus Cells. ( 27734404 )
2017
6
Phytomedicine in Joint Disorders. ( 28275210 )
2017
7
The effect of a functional appliance in the management of temporomandibular joint disorders in patients with juvenile idiopathic arthritis. ( 27716739 )
2017
8
No evidence of association between articular status and clinical symptoms in patients with temporomandibular joint disorders. ( 28215435 )
2017
9
Tinnitus in Temporomandibular Joint Disorders: Is it a Specific Somatosensory Tinnitus Subtype? ( 28452718 )
2017
10
Resveratrol, Potential Therapeutic Interest in Joint Disorders: A Critical Narrative Review. ( 28067817 )
2017
11
Quantification of cartilage oligomeric matrix protein (COMP) and a COMP neoepitope in synovial fluid of patients with different joint disorders by novel automated assays. ( 28473207 )
2017
12
EULAR recommendations for cardiovascular disease risk management in patients with rheumatoid arthritis and other forms of inflammatory joint disorders: 2015/2016 update. ( 27697765 )
2017
13
The intravoxel incoherent motion MRI of lateral pterygoid muscle: a quantitative analysis in patients with temporomandibular joint disorders. ( 28332854 )
2017
14
Inflammatory Joint Disorders and Neutrophilic Dermatoses: a Comprehensive Review. ( 28735350 )
2017
15
Balancing benefits and risks of glucocorticoids in rheumatic diseases and other inflammatory joint disorders: new insights from emerging data. An expert consensus paper from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). ( 26746234 )
2016
16
Correlation between skeletal Class II and temporo-mandibular joint disorders: a literature review. ( 26938175 )
2016
17
Temporomandibular Joint Disorders and Orofacial Pain. ( 26614951 )
2016
18
Temporomandibular joint disorders. ( 28163470 )
2016
19
Blue rubber bleb nevus syndrome with knee joint disorder. ( 27117831 )
2016
20
Comparison of High-field and Low-field Magnetic Resonance Imaging of Stifle Joint Disorders in Dogs. ( 27760030 )
2016
21
Feature selection and classification methodology for the detection of knee-joint disorders. ( 27000292 )
2016
22
Osteoblastoma of the temporal articular tubercle misdiagnosed asA a temporomandibular joint disorder. ( 28043747 )
2016
23
An institutional survey for knowledge-based and self-awareness assessment in temporomandibular joint disorders among dental students. ( 27411654 )
2016
24
Synovial fluid matrix metalloproteinase-2 and -9 activities in dogs suffering from joint disorders. ( 26902805 )
2016
25
Dentists' knowledge of occlusal splint therapy for bruxism and temporomandibular joint disorders. ( 27251967 )
2016
26
Recent Tissue Engineering Advances for the Treatment of Temporomandibular Joint Disorders. ( 27704395 )
2016
27
WITHDRAWN: Occlusal adjustment for treating and preventing temporomandibular joint disorders. ( 26727292 )
2016
28
Evaluation of validity and reliability of a methodology for measuring human postural attitude and its relation to temporomandibular joint disorders. ( 26768173 )
2016
29
Diagnosis of temporomandibular joint disorders: indication of imaging exams. ( 26832630 )
2016
30
Cerezen device provides treatment for temporomandibular joint disorders day and night. ( 27338922 )
2016
31
Atherosclerotic cardiovascular disease in patients with chronic inflammatory joint disorders. ( 26888573 )
2016
32
Improved Therapeutic Efficacy in Bone and Joint Disorders by Targeted Drug Delivery to Bone. ( 27803481 )
2016
33
Quantitative measurements of the articular areas of mandibular condyles with temporomandibular joint disorders using magnetic resonance imaging. ( 26715262 )
2015
34
Cytokine profile in the synovial fluid of patients with temporomandibular joint disorders: A systematic review. ( 26556103 )
2015
35
Temporomandibular joint disorder from skull-base osteomyelitis: a case report. ( 26550559 )
2015
36
Modeling of muscle forces in humans with and without temporomandibular joint disorders. ( 25865546 )
2015
37
The Evaluation of Head and Craniocervical Posture among Patients with and without Temporomandibular Joint Disorders- A Comparative Study. ( 26436048 )
2015
38
Dickkopfa89related protein 1 induces angiogenesis by upregulating vascular endothelial growth factor in the synovial fibroblasts of patients with temporomandibular joint disorders. ( 26239269 )
2015
39
Joint Arthroplasty With Osteochondral Grafting From the Knee for Posttraumatic or Degenerative Hand Joint Disorders. ( 26143968 )
2015
40
Comparison of Serum and Salivary Antioxidants in Patients with Temporomandibular Joint Disorders and Healthy Subjects. ( 26622281 )
2015
41
Synovial plicae and temporomandibular joint disorders: surgical findings. ( 25795190 )
2015
42
Temporomandibular joint disorders treated with articular injection: the effectiveness of plasma rich in growth factors-Endoret. ( 25974777 )
2015
43
WITHDRAWN: Arthrocentesis and lavage for treating temporomandibular joint disorders. ( 26677172 )
2015
44
Can pterygoid plate asymmetry be linked to temporomandibular joint disorders? ( 26125003 )
2015
45
Botulinum toxin therapy for temporomandibular joint disorders: a systematic review of randomized controlled trials. ( 25920597 )
2015
46
Contemporary management of temporomandibular joint disorders. ( 25483451 )
2015
47
Bone and Joint Disorders in Acromegaly. ( 25633971 )
2015
48
Stakeholder engagement analysis - a bioethics dilemma in patient-targeted intervention: patients with temporomandibular joint disorders. ( 25600231 )
2015
49
Association Between Harmful Oral Habits and Sign and Symptoms of Temporomandibular Joint Disorders Among Adolescents. ( 26436046 )
2015
50
Cell therapy in joint disorders. ( 25553210 )
2015

Variations for Joint Disorders

Expression for Joint Disorders

Search GEO for disease gene expression data for Joint Disorders.

Pathways for Joint Disorders

Pathways related to Joint Disorders according to GeneCards Suite gene sharing:

(show top 50) (show all 66)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.98 CSF1 IL11 IL17A IL18R1 IL1B IL1R1
2
Show member pathways
13.88 CSF1 IL11 IL17A IL18R1 IL1B IL1R1
3
Show member pathways
13.65 CSF1 IL11 IL17A IL18R1 IL1B IL1R1
4
Show member pathways
13.57 IL11 IL17A IL18R1 IL1B IL1R1 IL6
5
Show member pathways
13.33 CSF1 IL11 IL17A IL18R1 IL1B IL1R1
6
Show member pathways
13.28 CSF1 IL11 IL17A IL18R1 IL1B IL1R1
7
Show member pathways
13.21 CSF1 IL11 IL17A IL18R1 IL1B IL1R1
8
Show member pathways
13.04 IL18R1 IL1B IL1R1 IL1R2 IL1RN IL6
9
Show member pathways
12.76 IL1B IL1R1 IL1R2 IL6 TIMP1 TNF
10
Show member pathways
12.65 IL17A IL18R1 IL1B IL6 TIMP1 TNF
11
Show member pathways
12.63 IL17A IL18R1 IL1B IL1R1 IL6 IL6R
12 12.59 IL17A IL1B IL1RN TNF TNFSF11
13
Show member pathways
12.44 IL17A IL1B IL6 TNF
14 12.43 IL1R1 IL1R2 IL6 TNF
15
Show member pathways
12.39 IL17A IL1B IL6 IL6R MMP3 TNF
16
Show member pathways
12.33 IL1B IL1R1 IL1R2 IL1RN
17
Show member pathways
12.31 IL1B IL1R1 IL6 TNF
18 12.27 IL1R2 IL6 MMP3 PLAU
19
Show member pathways
12.24 IL11 IL1B IL1R1 IL6 TNF
20 12.23 IL1B IL1RN IL6 IL6R TNF
21
Show member pathways
12.2 IL17A IL1B IL6 TNF
22 12.14 IL1B IL1R1 IL1R2 TNF
23 12.12 CSF1 IL1B IL1R1 TNF TNFSF11
24 12.06 IL1B IL1R1 IL6 TNF
25 12.04 CSF1 IL11 IL6 TNF
26 12.03 IL1B IL6 IL6R PLAU SERPINB2
27
Show member pathways
12.03 IL17A IL18R1 IL1B IL6 TNF
28 12.01 CSF1 IL18R1 IL1B IL6 MMP3 TNF
29 11.97 IL17A IL1B IL6 IL6R MMP3 TIMP1
30 11.96 IL1B IL1R1 IL1R2 IL6 TNF
31
Show member pathways
11.96 IL17A IL1B IL1R1 IL6 IL6R
32 11.94 IL1B IL1R1 PLAU TNF TNFSF11
33 11.91 IL1B IL6 TNF
34 11.91 IL6 IL6R TIMP1
35
Show member pathways
11.91 MMP3 TIMP1 TNF
36
Show member pathways
11.9 IL6 IL6R TIMP1 TNFSF11
37
Show member pathways
11.88 IL17A IL6 IL6R
38 11.86 IL17A IL1B IL1R1 TNF
39 11.83 CSF1 IL1B IL6 TNF
40 11.78 IL1B IL6 TNF
41
Show member pathways
11.74 IL1B IL6 MMP3 TNF
42 11.74 CSF1 IL11 IL1B IL1R1 IL1R2 IL6
43 11.72 IL1B IL6 PLAU TIMP1 TNF
44 11.68 MMP3 PLAU TIMP1
45
Show member pathways
11.66 IL11 IL6 IL6R
46 11.63 IL1B IL6 TNF
47 11.58 IL1B IL6 TNF
48 11.57 IL1B IL6 TNF TNFSF11
49 11.56 IL6 PLAU TNF
50 11.56 IL1B SERPINB2 TNF

GO Terms for Joint Disorders

Cellular components related to Joint Disorders according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.77 CSF1 DKK1 IL11 IL17A IL1B IL1RN
2 extracellular region GO:0005576 9.53 CSF1 DKK1 IL11 IL17A IL1B IL1R1
3 interleukin-6 receptor complex GO:0005896 9.16 IL6 IL6R
4 plasma membrane GO:0005886 10.03 CSF1 DKK1 IL18R1 IL1R1 IL1R2 IL1RAPL2

Biological processes related to Joint Disorders according to GeneCards Suite gene sharing:

(show all 41)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.91 CSF1 IL11 IL6 IL6R TIMP1
2 inflammatory response GO:0006954 9.88 CSF1 IL17A IL1B IL1RN IL6 TNF
3 wound healing GO:0042060 9.85 IL6 SERPINB2 TIMP1
4 positive regulation of protein kinase B signaling GO:0051897 9.85 IL6 TNF TNFSF11
5 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.85 IL11 IL6 IL6R
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.85 IL1B IL6 TNF TNFSF11
7 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.83 IL11 IL6 TNF
8 positive regulation of JNK cascade GO:0046330 9.81 IL1B TNF TNFSF11
9 response to glucocorticoid GO:0051384 9.81 IL1RN IL6 TNF
10 response to cytokine GO:0034097 9.8 IL6 IL6R TIMP1
11 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.8 IL1B IL6 TNF TNFSF11
12 positive regulation of smooth muscle cell proliferation GO:0048661 9.79 IL6 IL6R TNF
13 positive regulation of nitric oxide biosynthetic process GO:0045429 9.76 IL1B IL6 TNF
14 positive regulation of interferon-gamma production GO:0032729 9.75 IL18R1 IL1B TNF
15 monocyte chemotaxis GO:0002548 9.74 IL6 IL6R TNFSF11
16 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.68 IL1B TNF
17 regulation of osteoclast differentiation GO:0045670 9.68 TNF TNFSF11
18 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.68 IL1B TNF
19 positive regulation of leukocyte chemotaxis GO:0002690 9.67 IL6 IL6R
20 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.66 IL1B TNF
21 negative regulation of hormone secretion GO:0046888 9.65 IL11 IL6
22 positive regulation of chemokine biosynthetic process GO:0045080 9.65 IL1B TNF
23 interleukin-6-mediated signaling pathway GO:0070102 9.65 IL6 IL6R
24 negative regulation of lipid storage GO:0010888 9.64 IL6 TNF
25 osteoclast differentiation GO:0030316 9.63 CSF1 TNF TNFSF11
26 regulation of establishment of endothelial barrier GO:1903140 9.62 IL1B TNF
27 positive regulation of interleukin-6 production GO:0032755 9.62 IL1B IL6 IL6R TNF
28 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.61 IL6 TNF
29 positive regulation of NF-kappaB import into nucleus GO:0042346 9.61 IL18R1 IL1B TNF
30 immune response GO:0006955 9.61 IL17A IL18R1 IL1B IL1R1 IL1R2 IL1RN
31 positive regulation of fever generation GO:0031622 9.59 IL1B TNF
32 sequestering of triglyceride GO:0030730 9.56 IL1B TNF
33 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.54 IL1B TNF
34 positive regulation of chemokine production GO:0032722 9.54 IL6 IL6R TNF
35 osteoclast proliferation GO:0002158 9.52 CSF1 TNFSF11
36 hepatic immune response GO:0002384 9.48 IL6 IL6R
37 positive regulation of osteoclast differentiation GO:0045672 9.46 CSF1 IL17A TNF TNFSF11
38 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.43 IL1R2 IL1RN IL6
39 fever generation GO:0001660 9.3 IL1B
40 cytokine-mediated signaling pathway GO:0019221 9.17 IL1B IL1R1 IL1R2 IL1RAPL2 IL6 IL6R
41 positive regulation of gene expression GO:0010628 10 CSF1 DKK1 IL1B IL6 TNF

Molecular functions related to Joint Disorders according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.55 CSF1 DKK1 IL11 IL6 TIMP1
2 interleukin-6 receptor binding GO:0005138 9.37 IL6 IL6R
3 interleukin-1 binding GO:0019966 9.32 IL1R1 IL1R2
4 cytokine activity GO:0005125 9.28 CSF1 IL11 IL17A IL1B IL1RN IL6
5 interleukin-1, Type II, blocking receptor activity GO:0004910 9.26 IL1R2 IL1RAPL2
6 interleukin-1 receptor activity GO:0004908 9.26 IL18R1 IL1R1 IL1R2 IL1RAPL2

Sources for Joint Disorders

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
19