MCID: JNT002
MIFTS: 52

Joint Disorders malady

Summaries for Joint Disorders

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MedlinePlus:34 A joint is where two or more bones come together, like the knee, hip, elbow, or shoulder. joints can be damaged by many types of injuries or diseases, including arthritis - inflammation of a joint. it causes pain, stiffness, and swelling. over time, the joint can become severely damaged. bursitis - inflammation of a fluid-filled sac that cushions the joint dislocations - injuries that force the ends of the bones out of position treatment of joint problems depends on the cause. if you have a sports injury, treatment often begins with the rice (rest, ice, compression, and elevation) method to relieve pain, reduce swelling, and speed healing. other possible treatments include pain relievers, keeping the injured area from moving, rehabilitation, and sometimes surgery. for arthritis, injuries, or other diseases, you may need joint replacement surgery to remove the damaged joint and put in a new one. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards based summary: Joint Disorders is related to arthritis and psoriatic arthritis. An important gene associated with Joint Disorders is SERPINB2 (serpin peptidase inhibitor, clade B (ovalbumin), member 2), and among its related pathways are Osteoblast Signaling and Osteoclast Signaling. The compounds polymyxin b and filgrastim have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and brain, and related mouse phenotypes are craniofacial and tumorigenesis.

Wikipedia:65 An arthropathy is a disease of a joint. more...

Aliases & Classifications for Joint Disorders

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Related Diseases for Joint Disorders

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Diseases related to Joint Disorders via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 145)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis30.1MMP3, TIMP1, TNFSF11, TNF, IL6
2psoriatic arthritis29.7TNF, TNFSF11, IL1RAPL2, MMP3, TNFRSF11B
3osteoarthritis29.7IL1RAPL2, IL1R1, IL1RN, IL6, CSF1, IL6R
4juvenile rheumatoid arthritis29.7IL6, IL18R1, IL1R1, IL1RN, IL1RAPL2, TNF
5rheumatoid arthritis29.4IL18R1, IL1RN, IL1RAPL2, IL1R2, IL1R1, IL11
6exostosis10.1
7periapical granuloma10.1TNFSF11
8dengue shock syndrome10.1IL1RN
9pigmented villonodular synovitis10.1CSF1
10hyper-igd syndrome10.1IL1RN
11periodontitis10.1TNFRSF11B
12cherubism10.1TNFSF11
13malignant histiocytosis10.1CSF1
14blau syndrome10.1TNF
15schnitzler syndrome10.0IL1R1, IL1RN
16pulpitis10.0TIMP1
17osteolysis, familial expansile10.0TNFRSF11B, TNFSF11
18paget disease, juvenile10.0TNFSF11, TNFRSF11B
19stomatitis10.0IL11
20megakaryocytic leukemia10.0IL11, IL6R
21giant cell tumor10.0TNFSF11, CSF1
22neisseria meningitidis infection10.0IL1R1, IL1RN
23alopecia areata10.0IL1RN, IL1R1
24hyperostosis, endosteal10.0TNFRSF11B, TNFSF11
25aortic valve disease 210.0TNFRSF11B, TNFSF11
26refractory anemia10.0IL11, CSF1
27conjunctivochalasis10.0MMP3, TIMP1
28hematologic cancer10.0IL11, CSF1, SERPINB2
29neutropenia10.0IL1RN, CSF1, IL11
30polymyalgia rheumatica10.0IL1RN, IL1RAPL2
31hodgkin lymphoma10.0IL1RN, IL6R, IL18R1
32osteopetrosis10.0CSF1, TNFSF11, TNFRSF11B
33bone cancer10.0TNFSF11, CSF1, TNFRSF11B
34bronchopulmonary dysplasia10.0IL1RN, TIMP1
35thalassemia, hispanic gamma-delta-beta10.0TNFSF11, TNFRSF11B
36relapsing-remitting multiple sclerosis10.0TIMP1, IL1RN
37acute respiratory distress syndrome10.0TNF, IL1R1
38cholesteatoma10.0TNFRSF11B, TNFSF11, MMP3
39muckle-wells syndrome10.0IL1R1, IL1RAPL2
40gastritis10.0IL1RN, IL1RAPL2
41gingival overgrowth10.0TIMP1, MMP3
42acute graft versus host disease10.0IL1RN, IL1R1, TNF
43uveitis10.0TNF, IL1R1, IL18R1
44multicentric castleman’s disease10.0IL6R, IL6
45multiple myeloma10.0TNFSF11, IL6
46sarcoma10.0IL18R1, IL1R1, SERPINB2, CSF1
47pancreatic cancer10.0IL1RN, SERPINB2, IL18R1, IL6R
48spondylarthropathy10.0TNF, IL1RAPL2
49kawasaki disease10.0MMP3, TIMP1
50cinca syndrome10.0IL1R1, IL1RAPL2, IL1RN

Graphical network of the top 20 diseases related to Joint Disorders:



Diseases related to joint disorders

Symptoms for Joint Disorders

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Drugs & Therapeutics for Joint Disorders

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Drug clinical trials:

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Search NIH Clinical Center for Joint Disorders

Cell-based therapeutics:


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The database of embryonic development, stem cell research and regenerative medicine
Read about Joint Disorders cell therapies at LifeMap Discovery.

Genetic Tests for Joint Disorders

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Anatomical Context for Joint Disorders

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MalaCards organs/tissues related to Joint Disorders:

33
Bone, Skin, Brain

Animal Models for Joint Disorders or affiliated genes

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Publications for Joint Disorders

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Articles related to Joint Disorders:

(show all 48)
idTitleAuthorsYear
1
Stakeholder engagement analysis - a bioethics dilemma in patient-targeted intervention: patients with temporomandibular joint disorders. (25600231)
2015
2
Modeling of muscle forces in humans with and without temporomandibular joint disorders. (25865546)
2015
3
Cell therapy in joint disorders. (25553210)
2015
4
A pilot study of ambulatory masticatory muscle activities in temporomandibular joint disorders diagnostic groups. (25865543)
2015
5
Contemporary management of temporomandibular joint disorders. (25483451)
2015
6
Bone and Joint Disorders in Acromegaly. (25633971)
2015
7
Synovial plicae and temporomandibular joint disorders: surgical findings. (25795190)
2015
8
Sacroiliac joint disorders in Abidjan: Epidemiological, clinical, radiological and etiological characteristics. (25860679)
2014
9
Comparing proton density and turbo spin echo T2 weighted static sequences with dynamic half-Fourier single-shot TSE pulse sequence at 3.0a88T in diagnosis of temporomandibular joint disorders: a prospective study. (24720606)
2014
10
Joint motion quality in vibroacoustic signal analysis for patients with patellofemoral joint disorders. (25496721)
2014
11
Cytopathologic diagnosis on joint lavage fluid for patients with temporomandibular joint disorders. (23904326)
2014
12
Pisotriquetral joint disorders: an under-recognized cause of ulnar side wrist pain. (24687844)
2014
13
Effectiveness of a home exercise program in combination with ultrasound therapy for temporomandibular joint disorders. (25540479)
2014
14
Comprehensive treatment of temporomandibular joint disorders. (24660643)
2014
15
Brain signature of chronic orofacial pain: a systematic review and meta-analysis on neuroimaging research of trigeminal neuropathic pain and temporomandibular joint disorders. (24759798)
2014
16
Quantitative measurements of the articular areas of mandibular condyles with temporomandibular joint disorders using magnetic resonance imaging. (25519808)
2014
17
Tibial tubercle osteotomy for patello-femoral joint disorders. (25326765)
2014
18
The use of low level laser therapy in the treatment of temporomandibular joint disorders. Review of the literature. (23722130)
2013
19
Oral splint for temporomandibular joint disorders with revolutionary fluid system. (24019797)
2013
20
Symptoms resembling temporomandibular joint disorder caused by a pleomorphic adenoma. (23763725)
2013
21
Arthrocentesis and temporomandibular joint disorders: clinical and radiological results of a prospective study. (24319462)
2013
22
Clinical-surgical treatment of temporomandibular joint disorder in a psoriatic arthritis patient. (23556553)
2013
23
Evaluation of Korean teenagers with temporomandibular joint disorders. (24471050)
2013
24
Clinical signs and symptoms of tinnitus in temporomandibular joint disorders: a pilot study comparing patients and non-patients. (25158368)
2013
25
CT Images of a Severe TMJ Osteoarthritis and Differential Diagnosis with Other Joint Disorders. (24381768)
2013
26
Surgical classification for temporomandibular joint disorders. (23787136)
2013
27
Evidence Based Approach for the Diagnosis of Temporomandibular Joint Disorders (TMD). (24431765)
2013
28
The importance of complementary exams for the diagnosis of temporomandibular joint disorders. (23768880)
2013
29
Response to letter to the editor by the American Society of Temporomandibular Joint Surgeons (ASTMJS) Re: G. Dimitroulis, a new surgical classification for temporomandibular joint disorders [Int. J. Oral Maxillofac. Surg. 42 (2013) 218-222]. (23773237)
2013
30
Intra-articular injections with corticosteroids and sodium hyaluronate for treating temporomandibular joint disorders: a systematic review. (24352399)
2013
31
WITHDRAWN: Hyaluronate for temporomandibular joint disorders. (24105378)
2013
32
Etiological factors of temporomandibular joint disorders. (23833510)
2012
33
Nasal obstruction may alleviate bruxism related temporomandibular joint disorders. (21041035)
2011
34
Increased levels of soluble cytokine receptors in the synovial fluid of temporomandibular joint disorders in relation to joint effusion on magnetic resonance images. (20149511)
2010
35
Assessing potential functionality of catechol-O-methyltransferase (COMT) polymorphisms associated with pain sensitivity and temporomandibular joint disorders. (20336436)
2010
36
Conservative care of temporomandibular joint disorder in a 35-year-old patient with spinal muscular atrophy type III: a case study. (19948309)
2009
37
Cutaneous events during treatment of chronic inflammatory joint disorders with anti-tumour necrosis factor alpha: a cross-sectional study. (18713230)
2008
38
Induction of osteoclast-like cells derived from the synovial lavage fluids of patients with temporomandibular joint disorders. (16979913)
2007
39
Gene therapy methods in bone and joint disorders. Evaluation of the adeno-associated virus vector in experimental models of articular cartilage disorders, periprosthetic osteolysis and bone healing. (17427340)
2007
40
Expression of receptor activator of nuclear factor-kappaB ligand in synovial tissue: comparison with degradation of articular cartilage in temporomandibular joint disorders. (17560137)
2007
41
Increase in RANKL: OPG ratio in synovia of patients with temporomandibular joint disorder. (16798863)
2006
42
Analysis of tumor necrosis factor-alpha, interleukin-6, interleukin-1beta, soluble tumor necrosis factor receptors I and II, interleukin-6 soluble receptor, interleukin-1 soluble receptor type II, interleukin-1 receptor antagonist, and protein in the synovial fluid of patients with temporomandibular joint disorders. (15716832)
2005
43
Interleukin-6 family of cytokines as biochemical markers of osseous changes in the temporomandibular joint disorders. (15121272)
2004
44
Expression of osteoprotegerin in synovial tissue and degradation of articular cartilage: comparison with arthroscopic findings of temporomandibular joint disorders. (12973279)
2003
45
Biomarkers of joint tissue metabolism in canine osteoarthritic and arthritic joint disorders. (12202124)
2002
46
Plasminogen activators and plasminogen activator inhibitors in synovial fluid. Difference between inflammatory joint disorders and osteoarthritis. (8441174)
1993
47
Ulnar variance in children--standard measurements for evaluation of ulnar shortening in juvenile rheumatoid arthritis, hereditary multiple exostosis and other bone or joint disorders in childhood. (2588029)
1989
48
Cervical spondylosis presenting as the facial pain of temporomandibular joint disorder. (5658372)
1968

Variations for Joint Disorders

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Expression for genes affiliated with Joint Disorders

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Search GEO for disease gene expression data for Joint Disorders.

Pathways for genes affiliated with Joint Disorders

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Pathways related to Joint Disorders according to GeneCards/GeneDecks:

(show all 44)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9TNFRSF11B, TNFSF11
29.9TNFSF11, TNFRSF11B
39.7TNF, CSF1
49.5IL6R, IL6, SERPINB2
59.5IL6, TNF
6
Show member pathways
9.5IL1R1, IL6, IL6R
79.4TNF, TNFSF11, IL1R1
8
Show member pathways
9.4TNF, TNFSF11, TNFRSF11B
9
Show member pathways
9.4TNF, TNFSF11, TNFRSF11B
109.3TIMP1, IL6, IL6R
11
Show member pathways
Serotonin Transporter Activity38
9.3IL1R1, TNFRSF11B, TNF
12
Show member pathways
IL-1 Signaling Pathway38
IL1-mediated signaling events38
9.3IL1RN, IL1R2, IL1R1
13
Show member pathways
9.3TNF, IL18R1, IL6
14
Show member pathways
IL27-mediated signaling events38
9.3TNF, IL18R1, IL6
159.2IL6R, IL6, TNF
16
Show member pathways
9.2TNF, TIMP1, MMP3
179.2CSF1, IL6, TNF
189.2TNF, IL1R1, IL6
19
Show member pathways
Immune response MIF in innate immunity response60
9.2IL6, IL1R1, TNF
209.1IL6R, IL6, TIMP1, TNFSF11
219.1IL6, IL1R2, MMP3
229.0TNF, IL1RN, IL6, IL6R
23
Show member pathways
Type III interferon signaling38
8.9IL6R, IL6, IL11
248.9TNF, TNFSF11, TNFRSF11B, IL6
25
Show member pathways
Apoptosis and survival TNFR1 signaling pathway60
TWEAK Signaling Pathway38
Apoptosis Modulation by HSP7038
HIV-1 Nef- Negative effector of Fas and TNF-alpha38
8.9TNF, TNFSF11, TNFRSF11B, IL6
26
Show member pathways
IL23-mediated signaling events38
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling38
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
8.8TNF, TIMP1, IL18R1, IL6
278.8IL1R1, IL11, TNF
288.8TNF, TNFSF11, TNFRSF11B, IL1R1, CSF1
29
Show member pathways
Apoptosis Modulation and Signaling38
Apoptosis38
8.7TNF, TNFRSF11B, IL1R1, IL1R2
308.7CSF1, IL6, IL18R1, MMP3, TNF
318.6IL6, IL1R2, IL1R1, TNF
32
Show member pathways
8.6IL1R1, IL1R2, IL1RN, IL6, IL6R
33
Show member pathways
8.6IL1R1, IL1R2, IL1RN, IL6, IL6R
34
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
8.4IL6, IL1R1, IL11, TNF
358.4TNF, SERPINB2, IL1R1, IL1R2, IL6
36
Show member pathways
8.2TNF, TIMP1, IL1R1, IL1R2, IL6
37
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
8.1TNF, IL1R1, IL1R2, IL1RN, IL18R1, IL6
387.8TNF, TNFSF11, MMP3, IL11, IL6, CSF1
39
Show member pathways
7.5TNF, TIMP1, IL11, IL1R1, IL18R1, IL6
407.2TNF, IL11, IL1R1, IL1R2, IL6, IL6R
41
Show member pathways
6.9TNF, TNFSF11, TIMP1, IL11, IL1R1, IL18R1
42
Show member pathways
6.3TNF, TNFSF11, TIMP1, IL11, IL1R1, IL1R2
43
Show member pathways
6.3TNF, TNFSF11, TIMP1, IL11, IL1R1, IL1R2
44
Show member pathways
6.0CSF1, TNF, TNFSF11, TNFRSF11B, TIMP1, IL11

Compounds for genes affiliated with Joint Disorders

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Compounds related to Joint Disorders according to GeneCards/GeneDecks:

(show top 50)    (show all 213)
idCompoundScoreTop Affiliating Genes
1polymyxin b458.7IL1RN, TNFSF11, TNFRSF11B, IL6, TNF
2filgrastim45 139.6IL1RN, IL18R1, IL6, CSF1, IL11
3sulfasalazine30 45 51 1311.6TNF, MMP3, IL1R1, CSF1, IL1RN, IL1RAPL2
4anakinra45 139.5TNF, TNFRSF11B, IL6, IL1RN, IL1RAPL2, IL1R1
5adalimumab45 51 1310.5IL1R1, MMP3, IL6, IL1RN, IL1RAPL2, TNF
6ascorbic acid45 269.4MMP3, IL1R1, SERPINB2, TNFRSF11B, TNFSF11, CSF1
7deoxypyridinoline458.4IL6R, IL11, MMP3, TNFRSF11B, TNFSF11
8il 10458.3IL6, IL1RN, IL1RAPL2, IL1R1, TNF, IL6R
9ivig458.3TNF, IL1R1, IL6, IL18R1, IL1RN, IL1RAPL2
10neopterin458.0CSF1, IL6R, IL6, IL18R1, IL1RN, IL1RAPL2
11rosiglitazone30 45 51 26 1312.0CSF1, IL1RAPL2, IL6, IL1RN, IL1R1, TIMP1
12sb 20358045 618.9IL1R1, MMP3, TIMP1, TNFRSF11B, TNF, IL1RN
13creatinine457.7IL1RN, IL6, IL6R, TNFRSF11B, IL1RAPL2, IL1R1
14ribonucleic acid457.6IL6R, IL1RN, SERPINB2, IL1RAPL2, IL11, MMP3
15leflunomide45 51 139.6IL6, IL18R1, IL1RN, IL1RAPL2, IL1R1, MMP3
16leukotriene b445 61 269.6CSF1, IL6, IL1RN, IL1RAPL2, IL1R1, TNF
17genistein45 30 61 3 26 1312.6CSF1, TNF, TNFSF11, TNFRSF11B, TIMP1, MMP3
18testosterone45 61 26 1310.6IL6R, TNFRSF11B, IL1R1, IL1RAPL2, IL1RN, IL6
19vitamin d457.5IL6, TNFRSF11B, TNFSF11, TIMP1, IL1RN, IL1R1
20calcitriol45 61 26 1310.5TIMP1, TNFRSF11B, TNFSF11, TNF, IL18R1, IL6
21endotoxin457.5IL1R1, IL11, SERPINB2, TNF, IL1RN, IL18R1
2212-o-tetradecanoylphorbol 13-acetate457.5IL6R, IL18R1, TIMP1, CSF1, SERPINB2, MMP3
23prednisolone45 30 139.4CSF1, IL6R, IL6, IL18R1, IL1RN, IL1RAPL2
24progesterone45 30 61 26 1311.3MMP3, TIMP1, SERPINB2, TNFRSF11B, CSF1, IL6R
25thalidomide45 51 61 1310.3IL11, TNFRSF11B, TNF, IL1R1, IL18R1, IL6
26methotrexate51 45 139.3IL6R, IL6, IL1RN, IL1RAPL2, IL1R1, MMP3
27fibrinogen457.1IL1RAPL2, IL1RN, IL6R, TNFRSF11B, IL6, TNF
28lactate457.1CSF1, IL6, IL1RN, IL1RAPL2, IL1R1, TIMP1
29phosphatidylinositol457.1IL1RAPL2, TNFRSF11B, TIMP1, IL11, TNFSF11, IL1RN
30thymidine45 268.1CSF1, IL6R, IL6, IL18R1, IL1RAPL2, IL11
31gp 130457.0CSF1, IL6R, IL6, IL18R1, IL1RAPL2, IL1R1
32cysteine457.0COMT, TNFRSF11B, IL11, TIMP1, IL18R1, IL1RN
33tgf beta1457.0TNF, CSF1, IL6, IL1RN, IL1RAPL2, IL11
34histamine45 30 269.0TNF, CSF1, IL6R, IL1RN, IL1RAPL2, IL11
35rantes456.9IL18R1, IL1RN, IL1RAPL2, IL1R1, IL11, MMP3
36heparin45 30 26 139.9IL11, MMP3, SERPINB2, TIMP1, TNFRSF11B, TNFSF11
37nitric oxide45 26 138.5TIMP1, IL11, IL1R1, TNFRSF11B, TNF, IL1RAPL2
38infliximab45 51 138.5IL1R1, IL11, MMP3, TIMP1, TNFRSF11B, TNFSF11
39indomethacin45 30 61 139.4CSF1, TNF, TNFSF11, IL6, IL1RN, IL1RAPL2
40serine456.3TIMP1, SERPINB2, MMP3, IL11, IL1R1, TNFRSF11B
41etanercept45 51 138.2IL11, MMP3, TIMP1, TNFRSF11B, TNFSF11, TNF
42prostaglandin456.2IL18R1, IL1RN, IL1RAPL2, IL1R1, IL11, MMP3
43tyrosine456.2IL1R1, IL11, IL1RN, IL18R1, IL6, IL6R
44estrogen456.1TNFSF11, TNFRSF11B, TIMP1, SERPINB2, MMP3, IL11
45cyclosporin a45 30 618.0IL1RAPL2, IL1R1, IL11, MMP3, SERPINB2, TIMP1
46cycloheximide456.0IL6R, IL6, IL1RN, IL1RAPL2, IL1R1, IL11
47pge2455.7SERPINB2, TIMP1, TNFRSF11B, TNFSF11, TNF, MMP3
48vegf455.7IL18R1, IL6, IL6R, TIMP1, SERPINB2, MMP3
49retinoic acid45 266.5IL6R, COMT, CSF1, IL6, IL18R1, IL1RN
50dexamethasone45 51 30 138.1SERPINB2, CSF1, IL6R, IL6, IL18R1, IL1R2

GO Terms for genes affiliated with Joint Disorders

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Cellular components related to Joint Disorders according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-6 receptor complexGO:00058969.5IL6, IL6R
2plasma membraneGO:00058867.4SERPINB2, IL1R1, IL1R2, IL1RN, IL18R1, IL6R
3extracellular spaceGO:00056156.7SERPINB2, TNFRSF11B, TNFSF11, TNF, MMP3, IL11
4extracellular regionGO:00055766.0IL6R, TNF, TNFSF11, TNFRSF11B, TIMP1, SERPINB2

Biological processes related to Joint Disorders according to GeneCards/GeneDecks:

(show all 37)
idNameGO IDScoreTop Affiliating Genes
1osteoclast proliferationGO:000215810.3TNFSF11, CSF1
2hepatic immune responseGO:000238410.1IL6, IL6R
3negative regulation of collagen biosynthetic processGO:003296610.1IL6R, IL6
4chronic inflammatory response to antigenic stimulusGO:000243910.1TNF, IL1RN
5neutrophil mediated immunityGO:000244610.1IL6R, IL6
6interleukin-6-mediated signaling pathwayGO:007010210.0IL6R, IL6
7monocyte chemotaxisGO:00025489.9IL6R, IL6, TNFSF11
8positive regulation of leukocyte chemotaxisGO:00026909.9IL6, IL6R
9acute-phase responseGO:00069539.9IL6R, IL6, IL1RN
10positive regulation of osteoclast differentiationGO:00456729.8TNF, TNFSF11, CSF1
11osteoclast differentiationGO:00303169.8CSF1, TNFSF11, TNF
12positive regulation of NF-kappaB import into nucleusGO:00423469.8IL18R1, TNF
13epithelial cell proliferation involved in salivary gland morphogenesisGO:00606649.8TNF, IL6
14negative regulation of lipid storageGO:00108889.8TNF, IL6
15defense response to Gram-negative bacteriumGO:00508299.8IL6R, IL6
16tumor necrosis factor-mediated signaling pathwayGO:00332099.7TNFSF11, TNF
17positive regulation of chemokine productionGO:00327229.6TNF, IL6, IL6R
18defense response to Gram-positive bacteriumGO:00508309.6IL6R, IL6, TNF
19positive regulation of JUN kinase activityGO:00435079.6TNF, IL1RN
20positive regulation of interleukin-6 productionGO:00327559.6TNF, IL6, IL6R
21positive regulation of smooth muscle cell proliferationGO:00486619.6IL6R, IL6, TNF
22positive regulation of protein kinase B signalingGO:00518979.6TNF, TNFSF11, IL6
23response to lipopolysaccharideGO:00324969.5COMT, IL6, IL1RN
24response to glucocorticoidGO:00513849.5IL6, IL1RN, TNF
25positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.5IL6, TNFSF11, TNF
26positive regulation of tyrosine phosphorylation of Stat3 proteinGO:00425179.5IL6, IL6R
27negative regulation of hormone secretionGO:00468889.4IL11, IL6
28positive regulation of NF-kappaB transcription factor activityGO:00510929.4IL6R, IL6, TNFSF11, TNF
29positive regulation of MAPK cascadeGO:00434109.3IL11, IL6, IL6R
30negative regulation of apoptotic processGO:00430669.2TIMP1, SERPINB2, IL1RN, IL6
31positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.2IL6R, IL6, IL11
32immune responseGO:00069559.2TNFSF11, IL1R1, IL1R2, IL1RN, IL18R1
33extracellular matrix organizationGO:00301989.1TNF, TNFRSF11B, TIMP1, MMP3
34positive regulation of peptidyl-serine phosphorylationGO:00331389.0IL6, IL11, TNF
35response to drugGO:00424938.9TNF, TNFRSF11B, IL1RN, IL6, COMT
36cytokine-mediated signaling pathwayGO:00192218.8IL6R, IL6, IL1RAPL2, IL1R2, TNFSF11
37positive regulation of cell proliferationGO:00082848.6TIMP1, IL11, IL6, IL6R, CSF1

Molecular functions related to Joint Disorders according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:00051649.7TNFSF11, TNF
2interleukin-6 receptor bindingGO:00051389.7IL6, IL6R
3interleukin-1, Type II, blocking receptor activityGO:00049109.4IL1R2, IL1RAPL2
4protease bindingGO:00020209.2IL1R1, TIMP1, TNF
5interleukin-1 receptor activityGO:00049088.9IL18R1, IL1RAPL2, IL1R2, IL1R1
6growth factor activityGO:00080838.6CSF1, IL6, IL11
7cytokine activityGO:00051257.9TNF, TNFSF11, TNFRSF11B, IL11, IL6, CSF1

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47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet