MCID: JVN001
MIFTS: 19

Juvenile Astrocytoma

Categories: Neuronal diseases, Cancer diseases

Aliases & Classifications for Juvenile Astrocytoma

MalaCards integrated aliases for Juvenile Astrocytoma:

Name: Juvenile Astrocytoma 12 14 69
Pediatric Astrocytoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3079
NCIt 46 C9022
UMLS 69 C1321865

Summaries for Juvenile Astrocytoma

MalaCards based summary : Juvenile Astrocytoma, also known as pediatric astrocytoma, is related to childhood cerebellar astrocytic neoplasm and childhood cerebral astrocytoma. An important gene associated with Juvenile Astrocytoma is XYLT1 (Xylosyltransferase 1), and among its related pathways/superpathways is heparan sulfate biosynthesis. Related phenotypes are cellular and embryo

Related Diseases for Juvenile Astrocytoma

Diseases in the Astrocytoma family:

Juvenile Astrocytoma

Diseases related to Juvenile Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 childhood cerebellar astrocytic neoplasm 11.0
2 childhood cerebral astrocytoma 11.0
3 astrocytoma 9.7

Symptoms & Phenotypes for Juvenile Astrocytoma

MGI Mouse Phenotypes related to Juvenile Astrocytoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.86 SDC4 SULF2 XYLT1 YWHAE CALR DDX3X
2 embryo MP:0005380 9.63 EXT1 SDC4 SULF2 CALR DDX3X ELAVL1
3 mortality/aging MP:0010768 9.56 EXT1 SDC4 SULF2 XYLT1 YWHAE CALR
4 muscle MP:0005369 9.02 SDC4 SULF2 YWHAE CALR DDX3X

Drugs & Therapeutics for Juvenile Astrocytoma

Search Clinical Trials , NIH Clinical Center for Juvenile Astrocytoma

Genetic Tests for Juvenile Astrocytoma

Anatomical Context for Juvenile Astrocytoma

Publications for Juvenile Astrocytoma

Articles related to Juvenile Astrocytoma:

# Title Authors Year
1
Pilocytic (juvenile) astrocytoma of the optic nerve. The influence of biopsy. ( 662271 )
1978

Variations for Juvenile Astrocytoma

Expression for Juvenile Astrocytoma

Search GEO for disease gene expression data for Juvenile Astrocytoma.

Pathways for Juvenile Astrocytoma

Pathways related to Juvenile Astrocytoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.46 EXT1 XYLT1

GO Terms for Juvenile Astrocytoma

Biological processes related to Juvenile Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 9.37 DDX3X YWHAE
2 negative regulation of translation GO:0017148 9.32 CALR DDX3X
3 positive regulation of translation GO:0045727 9.26 DDX3X ELAVL1
4 glycosaminoglycan metabolic process GO:0030203 9.16 SDC4 XYLT1
5 heparan sulfate proteoglycan biosynthetic process GO:0015012 8.96 EXT1 XYLT1
6 glycosaminoglycan biosynthetic process GO:0006024 8.8 EXT1 SDC4 XYLT1

Molecular functions related to Juvenile Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 acetylglucosaminyltransferase activity GO:0008375 8.62 EXT1 XYLT1

Sources for Juvenile Astrocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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