MCID: JVN001
MIFTS: 20

Juvenile Astrocytoma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Juvenile Astrocytoma

MalaCards integrated aliases for Juvenile Astrocytoma:

Name: Juvenile Astrocytoma 12 14 69
Pediatric Astrocytoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3079
NCIt 47 C9022
UMLS 69 C1321865

Summaries for Juvenile Astrocytoma

MalaCards based summary : Juvenile Astrocytoma, also known as pediatric astrocytoma, is related to childhood cerebellar astrocytic neoplasm and childhood cerebral astrocytoma. An important gene associated with Juvenile Astrocytoma is SULF2 (Sulfatase 2). The drugs Cyproheptadine and Histamine have been mentioned in the context of this disorder. Related phenotype is muscle.

Related Diseases for Juvenile Astrocytoma

Diseases in the Astrocytoma family:

Juvenile Astrocytoma

Diseases related to Juvenile Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 childhood cerebellar astrocytic neoplasm 10.9
2 childhood cerebral astrocytoma 10.9
3 astrocytoma 9.6
4 interstitial lung disease 7.1 CALR DDX3X ELAVL1 LINC-ROR PHLDA1 SULF2

Symptoms & Phenotypes for Juvenile Astrocytoma

MGI Mouse Phenotypes related to Juvenile Astrocytoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 8.92 CALR DDX3X SULF2 YWHAE

Drugs & Therapeutics for Juvenile Astrocytoma

Drugs for Juvenile Astrocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyproheptadine Approved Phase 2 129-03-3 2913
2
Histamine Approved, Investigational Phase 2 75614-87-8, 51-45-6 774
3
Megestrol acetate Approved, Vet_approved Phase 2 595-33-5 11683
4
Peginterferon alfa-2b Approved Phase 2 99210-65-8, 215647-85-1
5
Lenalidomide Approved Phase 2 191732-72-6 216326
6 Anti-Allergic Agents Phase 2
7 Antineoplastic Agents, Hormonal Phase 2
8 Antipruritics Phase 2
9 Appetite Stimulants Phase 2
10 Central Nervous System Stimulants Phase 2
11 Contraceptive Agents Phase 2
12 Contraceptives, Oral Phase 2
13 Dermatologic Agents Phase 2
14 Gastrointestinal Agents Phase 2
15 Histamine Antagonists Phase 2
16 Histamine H1 Antagonists Phase 2
17
Histamine Phosphate Phase 2 51-74-1 65513
18
Megestrol Phase 2 3562-63-8 19090 3080587
19 Neurotransmitter Agents Phase 2
20
Serotonin Phase 2 50-67-9 5202
21 Serotonin Agents Phase 2
22 Serotonin Antagonists Phase 2
23 Anti-Infective Agents Phase 2
24 Antiviral Agents Phase 2
25 Interferon-alpha Phase 2
26 interferons Phase 2
27 Angiogenesis Inhibitors Phase 2
28 Angiogenesis Modulating Agents Phase 2
29 Anti-Bacterial Agents Phase 2
30 Immunosuppressive Agents Phase 2
31
Topotecan Approved, Investigational Phase 1 119413-54-6, 123948-87-8 60700
32 topoisomerase I inhibitors Phase 1
33 Topoisomerase Inhibitors Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Cyproheptadine and Megestrol in Preventing Weight Loss in Children With Cachexia Caused By Cancer or Cancer Treatment Completed NCT00066248 Phase 2 cyproheptadine hydrochloride;megestrol acetate
2 Phase II Pegylated Interferon Recruiting NCT02343224 Phase 2 Pegylated interferon alpha-2b
3 Low-Dose or High-Dose Lenalidomide in Treating Younger Patients With Recurrent, Refractory, or Progressive Pilocytic Astrocytoma or Optic Pathway Glioma Active, not recruiting NCT01553149 Phase 2 Lenalidomide
4 Topotecan in Treating Young Patients With Neoplastic Meningitis Due to Leukemia, Lymphoma, or Solid Tumors Terminated NCT00112619 Phase 1 topotecan hydrochloride
5 Talotrexin in Treating Young Patients With Recurrent Solid Tumors or Leukemia That is Recurrent or Does Not Respond to Treatment Withdrawn NCT00458744 Phase 1 talotrexin

Search NIH Clinical Center for Juvenile Astrocytoma

Genetic Tests for Juvenile Astrocytoma

Anatomical Context for Juvenile Astrocytoma

Publications for Juvenile Astrocytoma

Articles related to Juvenile Astrocytoma:

id Title Authors Year
1
Pilocytic (juvenile) astrocytoma of the optic nerve. The influence of biopsy. ( 662271 )
1978

Variations for Juvenile Astrocytoma

Expression for Juvenile Astrocytoma

Search GEO for disease gene expression data for Juvenile Astrocytoma.

Pathways for Juvenile Astrocytoma

GO Terms for Juvenile Astrocytoma

Biological processes related to Juvenile Astrocytoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 G2/M transition of mitotic cell cycle GO:0000086 9.26 PHLDA1 YWHAE
2 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 9.16 DDX3X YWHAE
3 negative regulation of translation GO:0017148 8.96 CALR DDX3X
4 positive regulation of translation GO:0045727 8.62 DDX3X ELAVL1

Molecular functions related to Juvenile Astrocytoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 mRNA binding GO:0003729 8.96 CALR ELAVL1
2 RNA binding GO:0003723 8.92 CALR DDX3X ELAVL1 YWHAE

Sources for Juvenile Astrocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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