Juvenile Batten Disease malady

Genetics Home Reference: Juvenile Batten disease is an inherited disorder that primarily affects the nervous system. Beginning in childhood, affected individuals develop progressive vision loss, seizures, and intellectual decline.¹⁷

MalaCards: Juvenile Batten Disease, also known as ceroid lipofuscinosis, neuronal 3, juvenile, is related to batten disease and ceroid-lipofuscinosis, neuronal-3, juvenile. An important gene associated with Juvenile Batten Disease is CLN3 (ceroid-lipofuscinosis, neuronal 3).

juvenile batten disease 17 ceroid lipofuscinosis, neuronal 3, juvenile 43 cln3-related neuronal ceroid-lipofuscinosis 17 juvenile neuronal ceroid lipfuscinosis 43 batten-spielmeyer-vogt disease 17

spielmeyer-vogt disease 17 batten-mayou disease 17 classic juvenile ncl 17 juvenile disease 43 batten disease 17

Diseases related to juvenile batten disease by text searches and GeneDecks gene sharing:

(show all 12)

id	Related Disease	Score	Top Affiliating Genes
1	batten disease	9.4
2	ceroid-lipofuscinosis, neuronal-3, juvenile	9.1
3	neuronal ceroid-lipofuscinosis	9.1
4	ceroid lipofuscinosis	8.8
5	neuronal ceroid-lipofuscinoses	7.1
6	lysosomal storage disease	6.1
7	neuroblastoma	6.1
8	neuronal ceroid-lipofuscinosis, infantile	6.1
9	retinitis	6.1
10	seizures	6.1
11	muscular atrophy	5.1
12	spinal muscular atrophy	5.1

Approved drugs:

Drug clinical trials:

Articles related to juvenile batten disease:

id	Title	Authors	Year	Affiliating Genes
1	Interactions between the juvenile Batten disease gene, CLN3, and the Notch and JNK signalling pathways. (19028667)	Tuxworth R.I.... Tear G.	2009	CLN3
2	Moving towards therapies for juvenile Batten disease? (18400221)	Cooper J.D.	2008	CLN3
3	Attenuation of AMPA receptor activity improves motor skills in a mouse model of juvenile Batten disease. (17963751)	Kovacs A.D.... Pearce D.A.	2008	CLN3
4	Defective lysosomal arginine transport in juvenile Batten disease. (16251196)	Ramirez-Montealegre D.... Pearce D.A.	2005	CLN3
5	Cell death pathways in juvenile Batten disease. (16151633)	Persaud-Sawin D.A.... Boustany R.M.	2005	CLN3

Genes related to juvenile batten disease according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	CLN3	ceroid-lipofuscinosis, neuronal 3	11.0	Publications, Disorders