JMML
MCID: JVN004
MIFTS: 70

Juvenile Myelomonocytic Leukemia (JMML) malady

Genetic diseases, Rare diseases, Cancer diseases, Blood diseases categories
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Summaries for Juvenile Myelomonocytic Leukemia

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Wikipedia:65 Juvenile myelomonocytic leukemia (JMML) is a serious chronic leukemia (cancer of the blood) that affects... more...

MalaCards based summary: Juvenile Myelomonocytic Leukemia, also known as leukemia, juvenile myelomonocytic, is related to noonan syndrome and acute myeloid leukemia, and has symptoms including An important gene associated with Juvenile Myelomonocytic Leukemia is NF1 (neurofibromin 1), and among its related pathways are Thyroid cancer and EGFR Transactivation by Gastrin. The compounds pixy321 and pkc 412 have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone marrow and bone, and related mouse phenotypes are pigmentation and limbs/digits/tail.

Description from OMIM:46 607785

Aliases & Classifications for Juvenile Myelomonocytic Leukemia

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Sources:
30LifeMap Discovery®, 8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 62UMLS, 9diseasecard, 22GTR, 46OMIM, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet, 25ICD10
See all sources

Juvenile Myelomonocytic Leukemia, Aliases & Descriptions:

Name: Juvenile Myelomonocytic Leukemia 30 8 42 10 44 48 62
Leukemia, Juvenile Myelomonocytic 9 42 22 46
Juvenile Chronic Myelomonocytic Leukaemia 62
 
Juvenile Chronic Myelomonocytic Leukemia 48
Jmml 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases, Cancer diseases
Anatomical: Blood diseases


Characteristics (Orphanet epidemiological data):

48
juvenile myelomonocytic leukemia:
Prevalence: 1-9/1000000; Age of onset: Childhood


External Ids:

Disease Ontology8 DOID:0050458
MeSH34 D054429
OMIM46 607785
MESH via Orphanet35 D054429
ICD10 via Orphanet26 C93.3
UMLS via Orphanet63 C0349639
ICD1025 C93.3

Related Diseases for Juvenile Myelomonocytic Leukemia

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Diseases in the Juvenile Myelomonocytic Leukemia family:

Chronic Myelomonocytic Leukemia Acute Myelomonocytic Leukemia

Diseases related to Juvenile Myelomonocytic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 107)
idRelated DiseaseScoreTop Affiliating Genes
1noonan syndrome31.2PTPN11, NRAS, NF1, KRAS, HRAS
2acute myeloid leukemia31.2FLT3, RUNX1
3noonan syndrome 131.2PTPN11
4neurofibromatosis31.0PTPN11, PDGFRA, NF1, KRAS, HRAS
5acute lymphoblastic leukemia30.6RUNX1, PTPN11, FLT3, CSF2, KRAS, HRAS
6leukemia30.5RUNX1, PTPN11, FLT3, CBL, DNMT3A, CSF2
7myelodysplastic syndromes30.4RUNX1, PTPN11, FLT3, CSF2, PDGFRA, NRAS
8sarcoma30.2RUNX1, PDGFRA, NRAS, NF1, KRAS, HRAS
9myeloid leukemia29.9NF1, RARA, CSF2, CBL, FLT3, PTPN11
10chronic myeloid leukemia29.0HRAS, KRAS, NF1, RUNX1, PTPN11, FLT3
11hematopoietic stem cell transplantation10.8
12noonan-like syndrome disorder with or without juvenile myelomonocytic leukemia10.6
13cardiofaciocutaneous syndrome10.5KRAS
14chronic myelomonocytic leukemia10.5
15lymphoblastic leukemia10.5
16cytomegalovirus infection10.5
17hemophagocytic lymphohistiocytosis10.5
18cherubism10.5PTPN11
19neurofibromatosis-noonan syndrome10.4PTPN11, NF1
20thyroid carcinoma, follicular, somatic10.4NRAS, HRAS
21leopard syndrome10.4PTPN11, HRAS
22acute lymphocytic leukemia10.4
23juvenile xanthogranuloma10.4
24respiratory failure10.4
25plexiform neurofibroma10.4PDGFRA, NF1
26lynch syndrome10.3NRAS, KRAS
27bone marrow cancer10.3FLT3, NRAS, KRAS
28thyroid hurthle cell carcinoma10.3FLT3, HRAS
29megakaryocytic leukemia10.3CSF2, RUNX1
30exanthem10.3NRAS, KRAS, HRAS
31gallbladder cancer10.3NRAS, KRAS, HRAS
32acute myeloid leukemia, adult10.3RUNX1, PTPN11, FLT3
33costello syndrome10.3PTPN11, KRAS, HRAS
34refractory anemia10.3RUNX1, FLT3, CSF2
35short stature10.3HRAS, NF1, PTPN11
36pancreatitis10.2NRAS, KRAS, HRAS
37gastrointestinal stromal tumor10.2NF1, PDGFRA, FLT3
38skin benign neoplasm10.2HRAS, NF1, RARA
39hypereosinophilic syndrome10.2CSF2, PDGFRA
40bronchiolitis obliterans10.2
41graft versus host disease10.2
42hypertension10.2
43lymphoblastic lymphoma10.2
44myelodysplastic myeloproliferative cancer10.2
45osteopetrosis10.2
46pulmonary hypertension10.2
47severe combined immunodeficiency10.2
48systemic lupus erythematosus10.2
49thalassemia10.2
50thrombocytopenia10.2

Graphical network of the top 20 diseases related to Juvenile Myelomonocytic Leukemia:



Diseases related to juvenile myelomonocytic leukemia

Symptoms for Juvenile Myelomonocytic Leukemia

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Clinical features from OMIM:

607785

HPO human phenotypes related to Juvenile Myelomonocytic Leukemia:

id Description Frequency HPO Source Accession
1 somatic mutation HP:0001428
2 juvenile myelomonocytic leukemia HP:0012209

Drugs & Therapeutics for Juvenile Myelomonocytic Leukemia

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Drug clinical trials:

Search ClinicalTrials for Juvenile Myelomonocytic Leukemia

Search NIH Clinical Center for Juvenile Myelomonocytic Leukemia

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Juvenile Myelomonocytic Leukemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Juvenile Myelomonocytic Leukemia:
Hemacord
Embryonic/Adult Cultured Cells Related to Juvenile Myelomonocytic Leukemia:
Umbilical cord blood-derived hematopoietic progenitor cells (HEMACORD, PMID: 9828244

Genetic Tests for Juvenile Myelomonocytic Leukemia

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Genetic tests related to Juvenile Myelomonocytic Leukemia:

id Genetic test Affiliating Genes
1 Juvenile Myelomonocytic Leukemia22

Anatomical Context for Juvenile Myelomonocytic Leukemia

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MalaCards organs/tissues related to Juvenile Myelomonocytic Leukemia:

32
Myeloid, Bone marrow, Bone, T cells, Lymph node, Lung, Skin, Tonsil, Nk cells, B lymphoblasts, B cells

Animal Models for Juvenile Myelomonocytic Leukemia or affiliated genes

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MGI Mouse Phenotypes related to Juvenile Myelomonocytic Leukemia:

36 (show all 25)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011868.9PTPN11, CBL, PDGFRA, BTD, NF1, KRAS
2MP:00053718.6PTPN11, CBL, PDGFRA, NRAS, RARA, NF1
3MP:00053708.6RUNX1, PTPN11, CBL, NRAS, RARA, NF1
4MP:00053828.4PTPN11, CBL, CSF2, PDGFRA, RARA, NF1
5MP:00030128.3RUNX1, PTPN11, DNMT3A, PDGFRA, NRAS, HRAS
6MP:00053918.2PTPN11, BTD, NRAS, RARA, NF1, KRAS
7MP:00053678.1CSF2, PDGFRA, BTD, RARA, NF1, KRAS
8MP:00053888.0RUNX1, PTPN11, CBL, CSF2, PDGFRA, RARA
9MP:00053897.9PTPN11, CBL, DNMT3A, CSF2, PDGFRA, RARA
10MP:00107717.8RUNX1, PTPN11, CBL, CSF2, PDGFRA, BTD
11MP:00028737.8RUNX1, HBG1, PTPN11, PDGFRA, NRAS, RARA
12MP:00053857.8CSF2, CBL, PTPN11, RUNX1, PDGFRA, NRAS
13MP:00053807.7RUNX1, PTPN11, DNMT3A, CSF2, PDGFRA, NRAS
14MP:00053907.7RUNX1, PTPN11, CBL, CSF2, PDGFRA, BTD
15MP:00053697.7PTPN11, CBL, DNMT3A, PDGFRA, BTD, RARA
16MP:00053797.7PTPN11, CBL, DNMT3A, CSF2, PDGFRA, RARA
17MP:00036317.6PTPN11, DNMT3A, PDGFRA, RARA, NF1, KRAS
18MP:00053977.4RUNX1, PTPN11, FLT3, CBL, CSF2, PDGFRA
19MP:00053877.4RUNX1, PTPN11, FLT3, CBL, CSF2, PDGFRA
20MP:00020067.4HRAS, RUNX1, PTPN11, FLT3, CSF2, PDGFRA
21MP:00053867.4RUNX1, CBL, DNMT3A, CSF2, PDGFRA, BTD
22MP:00053847.2CBL, FLT3, PTPN11, RUNX1, DNMT3A, CSF2
23MP:00053766.9DNMT3A, CBL, FLT3, PTPN11, RUNX1, CSF2
24MP:00107686.8DNMT3A, CBL, FLT3, PTPN11, RUNX1, CSF2
25MP:00053786.4DNMT3A, CBL, FLT3, PTPN11, RUNX1, CSF2

Publications for Juvenile Myelomonocytic Leukemia

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Articles related to Juvenile Myelomonocytic Leukemia:

(show top 50)    (show all 207)
idTitleAuthorsYear
1
Mutations in GATA2 are rare in juvenile myelomonocytic leukemia. (24578498)
2014
2
Subclonal mutations in SETBP1 confer a poor prognosis in juvenile myelomonocytic leukemia. (25395418)
2014
3
Stem cell transplant for juvenile myelomonocytic leukemia and chronic myelomonocytic leukemia. (25332531)
2014
4
Treatment of disease recurrence after allogeneic hematopoietic stem cell transplantation in children with juvenile myelomonocytic leukemia: a great challenge still to be won. (22976832)
2013
5
Juvenile Myelomonocytic Leukemia in a Premature Neonate Mimicking Neonatal Sepsis. (24269860)
2013
6
Validation of flow cytometric phospho-STAT5 as a diagnostic tool for juvenile myelomonocytic leukemia. (24241400)
2013
7
Wiskott-Aldrich syndrome with unusual clinical features similar to juvenile myelomonocytic leukemia. (22736231)
2012
8
Constitutional NRAS mutations are rare among patients with Noonan syndrome or juvenile myelomonocytic leukemia. (22887781)
2012
9
Gene mutations in the Ras pathway and the prognostic implication in Korean patients with juvenile myelomonocytic leukemia. (21901340)
2012
10
Advances in the genetics of high-risk childhood B-progenitor acute lymphoblastic leukemia and juvenile myelomonocytic leukemia: implications for therapy. (22589484)
2012
11
Genetic analysis of TP53 in childhood myelodysplastic syndrome and juvenile myelomonocytic leukemia. (21784522)
2011
12
Mutations of an E3 ubiquitin ligase c-Cbl but not TET2 mutations are pathogenic in juvenile myelomonocytic leukemia. (20008299)
2010
13
CBL mutations in juvenile myelomonocytic leukemia and pediatric myelodysplastic syndrome. (20357823)
2010
14
Gene expression-based classification as an independent predictor of clinical outcome in juvenile myelomonocytic leukemia. (20231685)
2010
15
Infant juvenile myelomonocytic leukemia (JMML) with rapid infiltration of multiple organs. (20403038)
2010
16
Juvenile xanthogranuloma in a child with previously unsuspected neurofibromatosis type 1 and juvenile myelomonocytic leukemia. (19785027)
2010
17
A rare finding of deletion 5q in a child with juvenile myelomonocytic leukemia. (19963125)
2009
18
Negative regulation of Stat3 by activating PTPN11 mutants contributes to the pathogenesis of Noonan syndrome and juvenile myelomonocytic leukemia. (19509418)
2009
19
Cytomegalovirus infection mimicking juvenile myelomonocytic leukemia showing hypersensitivity to granulocyte-macrophage colony stimulating factor. (19731324)
2009
20
Concomitant EBV-related B-cell proliferation and juvenile myelomonocytic leukemia in a 2-year-old child. (17618684)
2008
21
Juvenile myelomonocytic leukemia and chronic myelomonocytic leukemia. (18548091)
2008
22
Role of mutation independent constitutive activation of FLT3 in juvenile myelomonocytic leukemia. (18024405)
2007
23
Targeting RAS signaling pathways in juvenile myelomonocytic leukemia. (17584027)
2007
24
The role of splenectomy in children with juvenile myelomonocytic leukemia. (17907514)
2007
25
Mutation analysis of the BRAF oncogene in juvenile myelomonocytic leukemia. (18024410)
2007
26
Identification of an immunogenic CD8+ T-cell epitope derived from gamma-globin, a putative tumor-associated antigen for juvenile myelomonocytic leukemia. (16778141)
2006
27
Chromosomal change during 6-mercaptopurine (6-MP) therapy in juvenile myelomonocytic leukemia: the growth of a 6-MP-refractory clone that already exists at onset. (16424864)
2006
28
Pulmonary hypertension in a child with juvenile myelomonocytic leukemia secondary to pulmonary leukemic cell infiltration. (17065143)
2006
29
Does hematopoietic stem cell transplantation improve patient outcome in juvenile myelomonocytic leukemia? (16264985)
2005
30
Hematopoietic stem cell transplantation (HSCT) in children with juvenile myelomonocytic leukemia (JMML): results of the EWOG-MDS/EBMT trial. (15353481)
2005
31
The mutational spectrum of PTPN11 in juvenile myelomonocytic leukemia and Noonan syndrome/myeloproliferative disease. (15928039)
2005
32
Little response to zoledronic acid in a child of juvenile myelomonocytic leukemia (JMML) harboring the PTPN11 mutation. (15857842)
2005
33
Allogeneic bone marrow transplantation for juvenile myelomonocytic leukemia: a single center experience of 23 patients. (15654356)
2005
34
Donor leukocyte infusion after hematopoietic stem cell transplantation in patients with juvenile myelomonocytic leukemia. (15800672)
2005
35
A 3-bp deletion mutation of PTPN11 in an infant with severe Noonan syndrome including hydrops fetalis and juvenile myelomonocytic leukemia. (15211660)
2004
36
Juvenile myelomonocytic leukemia. (15087069)
2004
37
Allogeneic bone marrow transplantation in juvenile myelomonocytic leukemia without total body irradiation. (15125615)
2004
38
The International Prognostic Scoring System (IPSS) for childhood myelodysplastic syndrome (MDS) and juvenile myelomonocytic leukemia (JMML). (15496981)
2004
39
HCMOGT-1 is a novel fusion partner to PDGFRB in juvenile myelomonocytic leukemia with t(5;17)(q33;p11.2). (15087372)
2004
40
Acute parvovirus B19 infection mimicking juvenile myelomonocytic leukemia. (11073169)
2000
41
Extramedullary relapse despite graft-versus-leukemia effect after bone marrow transplantation in a girl with juvenile myelomonocytic leukemia. (10342589)
1999
42
Juvenile myelomonocytic leukemia and Noonan syndrome. (10598665)
1999
43
A case of juvenile myelomonocytic leukemia with ocular infiltration. (10647883)
1999
44
RAS mutations and clonality analysis in children with juvenile myelomonocytic leukemia (JMML). (10049057)
1999
45
Differentiating juvenile myelomonocytic leukemia from infectious disease. (9414312)
1998
46
Mutations of the NF1 gene in children with juvenile myelomonocytic leukemia without clinical evidence of neurofibromatosis, type 1. (9639526)
1998
47
Unbalanced t(3;12) in a case of juvenile myelomonocytic leukemia (JMML) results in partial trisomy of 3q as defined by FISH. (9305599)
1997
48
EVI-1 gene expression in myeloid clonogenic cells from juvenile myelomonocytic leukemia (JMML). (9447818)
1997
49
Interleukin (IL)-10, but not IL-4 or IL-13, inhibits cytokine production and growth in juvenile myelomonocytic leukemia cells. (9012477)
1997
50
Juvenile myelomonocytic leukemia: molecular understanding and prospects for therapy. (8947912)
1996

Variations for Juvenile Myelomonocytic Leukemia

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UniProtKB/Swiss-Prot genetic disease variations for Juvenile Myelomonocytic Leukemia:

64 (show all 12)
id Symbol AA change Variation ID SNP ID
1ARHGAP26p.Asn417SerVAR_013623
2PTPN11p.Asp61ValVAR_015991
3PTPN11p.Asp61TyrVAR_015992
4PTPN11p.Glu69LysVAR_015993
5PTPN11p.Ala72ThrVAR_015996
6PTPN11p.Ala72ValVAR_015997
7PTPN11p.Glu76AlaVAR_015998
8PTPN11p.Glu76GlyVAR_015999
9PTPN11p.Glu76LysVAR_016000rs28933388
10PTPN11p.Glu76ValVAR_016001
11PTPN11p.Gly507AlaVAR_016002
12SETBP1p.Asp868AsnVAR_063807

Clinvar genetic disease variations for Juvenile Myelomonocytic Leukemia:

6 (show all 11)
id Gene Name Type Significance SNP ID Assembly Location
1PTPN11NM_002834.3(PTPN11): c.218C> T (p.Thr73Ile)single nucleotide variantPathogenicrs121918462GRCh37Chr 12, 112888202: 112888202
2PTPN11NM_002834.3(PTPN11): c.226G> A (p.Glu76Lys)single nucleotide variantPathogenicrs121918464GRCh37Chr 12, 112888210: 112888210
3PTPN11NM_002834.3(PTPN11): c.227A> T (p.Glu76Val)single nucleotide variantPathogenicrs121918465GRCh37Chr 12, 112888211: 112888211
4PTPN11NM_002834.3(PTPN11): c.227A> G (p.Glu76Gly)single nucleotide variantPathogenicrs121918465GRCh37Chr 12, 112888211: 112888211
5PTPN11NM_002834.3(PTPN11): c.227A> C (p.Glu76Ala)single nucleotide variantPathogenicrs121918465GRCh37Chr 12, 112888211: 112888211
6NF1NM_000267.3(NF1): c.4614G> A (p.Trp1538Ter)single nucleotide variantPathogenicrs137854555GRCh37Chr 17, 29588828: 29588828
7NF1NF1, IVS34, G-A, +18single nucleotide variantPathogenic
8NF1NM_000267.3(NF1): c.1642-8A> Gsingle nucleotide variantPathogenicrs267606602GRCh37Chr 17, 29548860: 29548860
9ARHGAP26NM_015071.4(ARHGAP26): c.1250A> G (p.Asn417Ser)single nucleotide variantPathogenicrs121918546GRCh37Chr 5, 142421420: 142421420
10ARHGAP26ARHGAP26, 52-BP INSinsertionPathogenic
11ARHGAP26ARHGAP26, 74-BP INSinsertionPathogenic

Expression for genes affiliated with Juvenile Myelomonocytic Leukemia

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Expression patterns in normal tissues for genes affiliated with Juvenile Myelomonocytic Leukemia

Search GEO for disease gene expression data for Juvenile Myelomonocytic Leukemia.

Pathways for genes affiliated with Juvenile Myelomonocytic Leukemia

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Pathways related to Juvenile Myelomonocytic Leukemia according to GeneCards/GeneDecks:

(show top 50)    (show all 96)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7HRAS, NRAS, KRAS
2
Show member pathways
EGFR-dependent Endothelin signaling events37
9.7KRAS, HRAS, NRAS
3
Show member pathways
9.7NRAS, HRAS, KRAS
49.7NRAS, HRAS, KRAS
59.6CSF2, NF1, HRAS
6
Show member pathways
Insulin Pathway37
9.6HRAS, PTPN11, CBL
7
Show member pathways
9.4KRAS, PTPN11, HRAS, NRAS
8
Show member pathways
9.4NRAS, KRAS, HRAS, PTPN11
9
Show member pathways
9.4HRAS, KRAS, NRAS, PTPN11
109.4NRAS, KRAS, HRAS, PTPN11
119.4KRAS, HRAS, CBL, PTPN11
12
Show member pathways
IL-9 Signaling Pathway37
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway37
Immune response IL 9 signaling pathway60
9.4PTPN11, CBL, HRAS, KRAS
13
Show member pathways
9.4CBL, KRAS, HRAS, NRAS
14
Show member pathways
ErbB receptor signaling network37
ErbB signaling pathway37
9.4NRAS, HRAS, KRAS, CBL
15
Show member pathways
Development Flt3 signaling60
9.3HRAS, CBL, FLT3, PTPN11
16
Show member pathways
9.3HRAS, NRAS, CBL, FLT3
179.3HRAS, PDGFRA, NRAS, NF1
18
Show member pathways
9.3NRAS, KRAS, HRAS, PDGFRA
19
Show member pathways
9.3HRAS, KRAS, NRAS, PDGFRA
209.2HRAS, NRAS, CBL, KRAS, PTPN11
219.2HRAS, CBL, NRAS, KRAS, PTPN11
22
Show member pathways
9.2KRAS, NRAS, HRAS, CBL, PTPN11
23
Show member pathways
Prolactin Signaling Pathway37
Development Prolactin receptor signaling60
Leptin signaling pathway37
9.2PTPN11, KRAS, CBL, HRAS, NRAS
24
Show member pathways
MAPK signaling pathway37
9.1NRAS, HRAS, KRAS, PDGFRA, NF1
259.0RUNX1, FLT3, RARA, CSF2
26
Show member pathways
MAPK Cascade37
Immune response Oncostatin M signaling via MAPK in human cells60
Oncostatin M Signaling Pathway37
9.0NRAS, PTPN11, SIPA1, HRAS, KRAS
27
Show member pathways
Development EDNRB signaling60
Development ACM2 and ACM4 activation of ERK60
Cell adhesion Integrin inside out signaling60
Development G Proteins mediated regulation MARK ERK signaling60
Signal transduction IP3 signaling60
Development Angiotensin signaling via PYK260
Development EPO induced MAPK pathway60
9.0PDGFRA, HRAS, KRAS, CBL, NRAS
289.0HRAS, CSF2, PDGFRA, NRAS, KRAS
29
Show member pathways
9.0PDGFRA, NRAS, HRAS, KRAS, FLT3
30
Show member pathways
8.9CSF2, CBL, PTPN11, HRAS, NRAS, KRAS
31
Show member pathways
8.9PTPN11, CBL, CSF2, NRAS, HRAS, KRAS
32
Show member pathways
Immune response BCR pathway60
Fc-epsilon receptor I signaling in mast cells37
8.9CBL, CSF2, KRAS, HRAS, PTPN11, NRAS
33
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
8.9HRAS, KRAS, NRAS, CSF2, CBL, PTPN11
34
Show member pathways
Immune response CD16 signaling in NK cells60
8.9NRAS, KRAS, CBL, PTPN11, HRAS, CSF2
358.9HRAS, KRAS, CBL, RARA, PTPN11
36
Show member pathways
8.8HRAS, KRAS, NRAS, CBL, PTPN11, RUNX1
37
Show member pathways
Signaling Pathways in Glioblastoma37
8.8KRAS, HRAS, CBL, PDGFRA, NRAS, NF1
38
Show member pathways
8.8KRAS, PDGFRA, CBL, PTPN11, HRAS, NRAS
39
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events37
ErbB2/ErbB3 signaling events37
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
8.8NRAS, CBL, PTPN11, HRAS, KRAS, PDGFRA
40
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor37
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
8.8PDGFRA, CBL, PTPN11, HRAS, KRAS, NRAS
41
Show member pathways
8.8PTPN11, CBL, HRAS, KRAS, NRAS, PDGFRA
42
Show member pathways
8.8HRAS, KRAS, NRAS, PDGFRA, PTPN11, CBL
438.7PDGFRA, DNMT3A, HRAS, NRAS, KRAS
44
Show member pathways
8.5PDGFRA, PTPN11, HRAS, NRAS, NF1, SIPA1
45
Show member pathways
8.4RARA, NRAS, PDGFRA, HRAS, FLT3, CSF2
46
Show member pathways
8.4CBL, PDGFRA, NRAS, SIPA1, KRAS, HRAS
478.3PDGFRA, BTD, PTPN11, KRAS, HRAS, CBL
48
Show member pathways
Signal transduction PTEN pathway60
8.2HRAS, KRAS, NRAS, CBL, RARA, FLT3
49
Show member pathways
7.9FLT3, RARA, CBL, PDGFRA, NRAS, HRAS
507.9HRAS, KRAS, NRAS, PDGFRA, CBL, FLT3

Compounds for genes affiliated with Juvenile Myelomonocytic Leukemia

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Compounds related to Juvenile Myelomonocytic Leukemia according to GeneCards/GeneDecks:

(show top 50)    (show all 52)
idCompoundScoreTop Affiliating Genes
1pixy3214410.2CSF2, FLT3
2pkc 4124410.1PDGFRA, FLT3
3ag-12964410.1PDGFRA, FLT3
4idarubicin50 44 1112.1FLT3, CSF2
5ponatinib50 1110.9FLT3, PDGFRA
6methylcellulose449.8CSF2, FLT3, HBG1
7sunitinib44 50 1111.8PDGFRA, FLT3
8cytarabine44 50 1111.7CSF2, FLT3, HBG1
9gp 130449.7PTPN11, FLT3, CSF2, HRAS
10herbimycin a44 6110.7PTPN11, FLT3, CSF2, HRAS
11hydroxyurea44 50 1111.7PDGFRA, CSF2, HBG1
12cisplatin44 50 61 1112.6PTPN11, CSF2, KRAS, HRAS
13tgf beta1449.5FLT3, PDGFRA, RARA
14lysine449.5NF1, BTD, CBL, PTPN11
15wortmannin449.5PTPN11, CBL, CSF2, KRAS, HRAS
16ly294002449.5PTPN11, RARA, KRAS, HRAS
17phenylalanine449.5HRAS, BTD, CBL, PTPN11
18h2o2449.5PTPN11, CBL, CSF2, KRAS, HRAS
19phosphotyrosine449.4HRAS, PDGFRA, CBL, FLT3, PTPN11
2012-o-tetradecanoylphorbol 13-acetate449.4HRAS, RARA, CSF2, RUNX1
21threonine449.3RUNX1, PTPN11, FLT3, CBL, HRAS
22fatty acid449.3HBG1, BTD, NF1, KRAS
23valine449.3HRAS, KRAS, CSF2
24agar449.3PTPN11, CSF2, NRAS, RARA, HRAS
25etoposide44 50 61 1112.3RUNX1, PTPN11, FLT3, CSF2, RARA
26atp44 2810.2HRAS, NF1, PDGFRA, FLT3, PTPN11
27arsenite44 2410.2RUNX1, FLT3, RARA
28paraffin449.2PDGFRA, RARA, NF1, KRAS, HRAS
29doxorubicin44 50 1111.2HRAS, CSF2, FLT3, HBG1, RUNX1
305-aza-2deoxycytidine449.2DNMT3A, FLT3, HBG1
31aspartate449.1HRAS, RARA, PDGFRA, FLT3
32butyrate449.1RUNX1, HBG1, CSF2, RARA, KRAS
33alanine449.0PTPN11, CBL, BTD, RARA, NF1
34lipid449.0PTPN11, CBL, RARA, NF1, KRAS, HRAS
35phosphoinositide449.0PTPN11, FLT3, CBL, RARA, KRAS, HRAS
36arginine449.0PTPN11, BTD, RARA, NF1, HRAS
37rapamycin449.0PTPN11, FLT3, CBL, PDGFRA, NF1, KRAS
38folate449.0RARA, PDGFRA, DNMT3A
39oxygen44 249.9HRAS, KRAS, RARA, PTPN11, HBG1
40estrogen448.9CSF2, PDGFRA, RARA, NF1, KRAS, HRAS
41thymidine44 249.9PTPN11, FLT3, CSF2, PDGFRA, RARA, HRAS
42imatinib44 50 1110.7RUNX1, PTPN11, FLT3, CBL, PDGFRA, RARA
43cysteine448.5PTPN11, CBL, CSF2, BTD, RARA, NF1
44vegf448.3RUNX1, PTPN11, FLT3, CSF2, PDGFRA, RARA
45serine448.2RUNX1, PTPN11, CBL, BTD, RARA, NF1
46phosphatidylinositol448.2PTPN11, FLT3, CBL, CSF2, PDGFRA, RARA
47retinoic acid44 249.1RUNX1, FLT3, CBL, CSF2, PDGFRA, RARA
48zinc44 248.9RUNX1, HBG1, CBL, DNMT3A, BTD, RARA
49oligonucleotide447.5HRAS, RUNX1, PTPN11, FLT3, DNMT3A, PDGFRA
50tyrosine447.1RUNX1, PTPN11, FLT3, CBL, CSF2, PDGFRA

GO Terms for genes affiliated with Juvenile Myelomonocytic Leukemia

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Cellular components related to Juvenile Myelomonocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:0056346.1HRAS, SPECC1, PTPN11, SETBP1, CBL, DNMT3A

Biological processes related to Juvenile Myelomonocytic Leukemia according to GeneCards/GeneDecks:

(show all 32)
idNameGO IDScoreTop Affiliating Genes
1myeloid progenitor cell differentiationGO:00231810.1FLT3, RUNX1
2dendritic cell differentiationGO:09702810.1FLT3, CSF2
3positive regulation of Rac protein signal transductionGO:03502210.0HRAS, KRAS, NRAS
4striated muscle cell differentiationGO:05114610.0HRAS, KRAS, NRAS
5activation of MAPKK activityGO:0001869.9NRAS, KRAS, HRAS
6positive regulation of MAP kinase activityGO:0434069.9FLT3, KRAS, HRAS
7negative regulation of granulocyte differentiationGO:0308539.9RARA, RUNX1
8regulation of synaptic transmission, GABAergicGO:0322289.9HRAS, KRAS, NF1, NRAS
9regulation of long-term neuronal synaptic plasticityGO:0481699.8NRAS, NF1, KRAS, HRAS
10visual learningGO:0085429.8HRAS, KRAS, NF1, NRAS
11positive regulation of phosphatidylinositol 3-kinase activityGO:0435529.8PDGFRA, FLT3
12MAPK cascadeGO:0001659.8NRAS, NF1, KRAS, HRAS
13Ras protein signal transductionGO:0072659.8HRAS, KRAS, NF1, NRAS
14positive regulation of DNA replicationGO:0457409.8HRAS, PDGFRA, CSF2
15leukocyte migrationGO:0509009.8HRAS, KRAS, NRAS, PTPN11
16insulin receptor signaling pathwayGO:0082869.8PTPN11, NRAS, KRAS, HRAS
17negative regulation of neuron apoptotic processGO:0435249.7NRAS, KRAS, HRAS
18liver developmentGO:0018899.7RUNX1, RARA, NF1
19actin cytoskeleton organizationGO:0300369.6NRAS, NF1, KRAS, HRAS, ARHGAP26
20adrenal gland developmentGO:0303259.6NF1, PDGFRA
21small GTPase mediated signal transductionGO:0072649.6ARHGAP26, HRAS, KRAS, NRAS
22GTP catabolic processGO:0061849.6HRAS, KRAS, NRAS
23axon guidanceGO:0074119.5HRAS, KRAS, NRAS, PTPN11
24Fc-epsilon receptor signaling pathwayGO:0380959.4PTPN11, PDGFRA, NRAS, KRAS, HRAS
25neurotrophin TRK receptor signaling pathwayGO:0480119.4PTPN11, PDGFRA, NRAS, KRAS, HRAS
26positive regulation of phosphatidylinositol 3-kinase signalingGO:0140689.4FLT3, CBL, PDGFRA, RARA
27positive regulation of ERK1 and ERK2 cascadeGO:0703749.3PDGFRA, RARA, HRAS
28innate immune responseGO:0450879.3HRAS, KRAS, NRAS, PDGFRA, PTPN11
29blood coagulationGO:0075969.3HRAS, KRAS, NRAS, PTPN11, HBG1
30fibroblast growth factor receptor signaling pathwayGO:0085439.2PTPN11, CBL, PDGFRA, NRAS, KRAS, HRAS
31epidermal growth factor receptor signaling pathwayGO:0071739.2PTPN11, CBL, PDGFRA, NRAS, KRAS, HRAS
32positive regulation of cell proliferationGO:0082848.6FLT3, CSF2, PDGFRA, NRAS, RARA, KRAS

Molecular functions related to Juvenile Myelomonocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1vascular endothelial growth factor-activated receptor activityGO:0050219.8PDGFRA, FLT3
2protein bindingGO:0055155.9ARHGAP26, RUNX1, PTPN11, FLT3, CBL, DNMT3A

Products for genes affiliated with Juvenile Myelomonocytic Leukemia

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  • Antibodies
  • Proteins
  • Lysates

Sources for Juvenile Myelomonocytic Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet