JMML
MCID: JVN004
MIFTS: 69

Juvenile Myelomonocytic Leukemia (JMML) malady

Genetic diseases, Rare diseases, Cancer diseases, Blood diseases categories

Summaries for Juvenile Myelomonocytic Leukemia

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66Wikipedia, 48OMIM, 34MalaCards
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Wikipedia:66 Juvenile myelomonocytic leukemia (JMML) is a serious chronic leukemia (cancer of the blood) that affects... more...

MalaCards: Juvenile Myelomonocytic Leukemia, also known as leukemia, juvenile myelomonocytic, is related to leukemia and noonan syndrome. An important gene associated with Juvenile Myelomonocytic Leukemia is NF1 (neurofibromin 1), and among its related pathways are Thyroid cancer and EGFR Transactivation by Gastrin. The compounds pixy321 and pkc 412 have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone marrow and bone, and related mouse phenotypes are pigmentation and limbs/digits/tail.

Description from OMIM:48 607785

Aliases & Classifications for Juvenile Myelomonocytic Leukemia

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9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 46Novoseek, 50Orphanet, 32LifeMap Discoveryā„¢, 63UMLS, 10diseasecard, 23GTR, 48OMIM, 36MeSH, 37MESH via Orphanet, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases, Cancer diseases
Anatomical: Blood diseases


Characteristics (Orphanet epidemiological data):

50
juvenile myelomonocytic leukemia:
Prevalence: 1-9/1000000; Age of onset: Childhood


Aliases & Descriptions:

juvenile myelomonocytic leukemia 9 44 11 46 50 32 63
leukemia, juvenile myelomonocytic 10 44 23 48
juvenile chronic myelomonocytic leukemia 50
jmml 44


External Ids:

Disease Ontology9 DOID:0050458
MeSH36 D054429
OMIM48 607785
MESH via Orphanet37 D054429
ICD10 via Orphanet27 C93.3
SNOMED-CT via Orphanet60 128832006, 277587001, 445227008
UMLS via Orphanet64 C0349639
ICD1026 C93.3

Related Diseases for Juvenile Myelomonocytic Leukemia

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18GeneCards, 19GeneDecks
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Diseases in the Juvenile Myelomonocytic Leukemia family:

Acute Myelomonocytic Leukemia Chronic Myelomonocytic Leukemia

Diseases related to Juvenile Myelomonocytic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 100)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.6PDGFRA, PTPN11, FLT3, CBL, RUNX1, DNMT3A
2noonan syndrome31.1HRAS, KRAS, NF1, PTPN11, NRAS
3neurofibromatosis30.9NF1, PTPN11, HRAS, KRAS, PDGFRA
4myelodysplastic syndromes30.9NF1, KRAS, RUNX1, PTPN11, FLT3, CSF2
5acute myeloid leukemia30.7FLT3, RUNX1
6chronic myelomonocytic leukemia30.6PTPN11, FLT3, CSF2, PDGFRA, RUNX1, NF1
7noonan syndrome 130.5PTPN11
8acute lymphocytic leukemia30.5HRAS, KRAS, CSF2, PTPN11, FLT3, RUNX1
9myeloid leukemia30.5CBL, FLT3, PTPN11, HBG1, CSF2, RARA
10sarcoma30.3NF1, NRAS, PDGFRA, RUNX1, KRAS, HRAS
11myeloproliferative disorder30.1HRAS, NF1, SIPA1, PDGFRA, CSF2, FLT3
12chronic myeloid leukemia30.0RUNX1, PTPN11, CBL, CSF2, PDGFRA, NRAS
13hematopoietic stem cell transplantation10.7
14noonan-like syndrome disorder with or without juvenile myelomonocytic leukemia10.6
15lymphoblastic leukemia10.5
16cytomegalovirus infection10.5
17hemophagocytic lymphohistiocytosis10.4
18juvenile xanthogranuloma10.4
19respiratory failure10.4
20graft versus host disease10.2
21langerhans-cell histiocytosis10.2
22bronchiolitis10.2
23bronchiolitis obliterans10.2
24diabetes insipidus10.2
25biotinidase deficiency10.2
26tonsillitis10.2
27adenoiditis10.2
28diphtheria10.2
29beta thalassemia10.2
30wiskott-aldrich syndrome10.2
31systemic lupus erythematosus10.2
32down syndrome10.2
33cervicitis10.2
34histiocytosis10.2
35hypertension10.2
36lupus erythematosus10.2
37myelodysplastic myeloproliferative cancer10.2
38severe combined immunodeficiency10.2
39thalassemia10.2
40thrombocytopenia10.2
41hydrops fetalis10.2
42lupus nephritis10.2
43sepsis10.2
44nephritis10.2
45cardiofaciocutaneous syndrome10.1KRAS
46cherubism10.1PTPN11
47neurofibromatosis-noonan syndrome10.1PTPN11, NF1
48thyroid carcinoma, follicular, somatic10.1HRAS, NRAS
49leopard syndrome10.1HRAS, PTPN11
50plexiform neurofibroma10.1PDGFRA, NF1

Graphical network of the top 20 diseases related to Juvenile Myelomonocytic Leukemia:



Diseases related to juvenile myelomonocytic leukemia

Symptoms for Juvenile Myelomonocytic Leukemia

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48OMIM
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Clinical features from OMIM:

607785

Drugs & Therapeutics for Juvenile Myelomonocytic Leukemia

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 32LifeMap Discoveryā„¢, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Juvenile Myelomonocytic Leukemia

Drug clinical trials:

Search ClinicalTrials for Juvenile Myelomonocytic Leukemia

Search NIH Clinical Center for Juvenile Myelomonocytic Leukemia

Search CenterWatch for Juvenile Myelomonocytic Leukemia

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Juvenile Myelomonocytic Leukemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Juvenile Myelomonocytic Leukemia:
Hemacord
Embryonic/Adult Cultured Cells Related to Juvenile Myelomonocytic Leukemia:
Umbilical cord blood-derived hematopoietic progenitor cells (HEMACORD, PMID: 9828244

Genetic Tests for Juvenile Myelomonocytic Leukemia

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23GTR
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Genetic tests related to Juvenile Myelomonocytic Leukemia:

id Genetic test Affiliating Genes
1 Juvenile Myelomonocytic Leukemia23

Anatomical Context for Juvenile Myelomonocytic Leukemia

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34MalaCards
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MalaCards organs/tissues related to Juvenile Myelomonocytic Leukemia:

34
Myeloid, Bone marrow, Bone, T cells, B lymphoblasts, Nk cells, Tonsil, Skin, Lung, Lymph node, B cells

Animal Models for Juvenile Myelomonocytic Leukemia or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Juvenile Myelomonocytic Leukemia:

38 (show all 25)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011868.9PTPN11, CBL, PDGFRA, BTD, NF1, KRAS
2MP:00053718.6PTPN11, CBL, PDGFRA, NRAS, RARA, NF1
3MP:00053708.6RUNX1, PTPN11, CBL, NRAS, RARA, NF1
4MP:00053828.4PTPN11, CBL, CSF2, PDGFRA, RARA, NF1
5MP:00030128.3RUNX1, PTPN11, DNMT3A, PDGFRA, NRAS, HRAS
6MP:00053918.2PTPN11, BTD, NRAS, RARA, NF1, KRAS
7MP:00053678.1CSF2, PDGFRA, BTD, RARA, NF1, KRAS
8MP:00053888.0RUNX1, PTPN11, CBL, CSF2, PDGFRA, RARA
9MP:00053897.9PTPN11, CBL, DNMT3A, CSF2, PDGFRA, RARA
10MP:00107717.8RUNX1, PTPN11, CBL, CSF2, PDGFRA, BTD
11MP:00028737.8RUNX1, HBG1, PTPN11, PDGFRA, NRAS, RARA
12MP:00053857.8CSF2, CBL, PTPN11, RUNX1, PDGFRA, NRAS
13MP:00053807.7RUNX1, PTPN11, DNMT3A, CSF2, PDGFRA, NRAS
14MP:00053907.7RUNX1, PTPN11, CBL, CSF2, PDGFRA, BTD
15MP:00053697.7PTPN11, CBL, DNMT3A, PDGFRA, BTD, RARA
16MP:00053797.7PTPN11, CBL, DNMT3A, CSF2, PDGFRA, RARA
17MP:00036317.6PTPN11, DNMT3A, PDGFRA, RARA, NF1, KRAS
18MP:00053977.4RUNX1, PTPN11, FLT3, CBL, CSF2, PDGFRA
19MP:00053877.4RUNX1, PTPN11, FLT3, CBL, CSF2, PDGFRA
20MP:00020067.4HRAS, RUNX1, PTPN11, FLT3, CSF2, PDGFRA
21MP:00053867.4RUNX1, CBL, DNMT3A, CSF2, PDGFRA, BTD
22MP:00053847.2CBL, FLT3, PTPN11, RUNX1, DNMT3A, CSF2
23MP:00053766.9DNMT3A, CBL, FLT3, PTPN11, RUNX1, CSF2
24MP:00107686.8DNMT3A, CBL, FLT3, PTPN11, RUNX1, CSF2
25MP:00053786.4DNMT3A, CBL, FLT3, PTPN11, RUNX1, CSF2

Publications for Juvenile Myelomonocytic Leukemia

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53PubMed
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Articles related to Juvenile Myelomonocytic Leukemia:

(show top 50)    (show all 190)
idTitleAuthorsYear
1
Treatment of disease recurrence after allogeneic hematopoietic stem cell transplantation in children with juvenile myelomonocytic leukemia: a great challenge still to be won. (22976832)
2013
2
Juvenile Myelomonocytic Leukemia in a Premature Neonate Mimicking Neonatal Sepsis. (24269860)
2013
3
Validation of flow cytometric phospho-STAT5 as a diagnostic tool for juvenile myelomonocytic leukemia. (24241400)
2013
4
Wiskott-Aldrich syndrome with unusual clinical features similar to juvenile myelomonocytic leukemia. (22736231)
2012
5
Constitutional NRAS mutations are rare among patients with Noonan syndrome or juvenile myelomonocytic leukemia. (22887781)
2012
6
Gene mutations in the Ras pathway and the prognostic implication in Korean patients with juvenile myelomonocytic leukemia. (21901340)
2012
7
Advances in the genetics of high-risk childhood B-progenitor acute lymphoblastic leukemia and juvenile myelomonocytic leukemia: implications for therapy. (22589484)
2012
8
Current management of juvenile myelomonocytic leukemia and the impact of RAS mutations. (22480363)
2012
9
Genetic analysis of TP53 in childhood myelodysplastic syndrome and juvenile myelomonocytic leukemia. (21784522)
2011
10
Mutations of an E3 ubiquitin ligase c-Cbl but not TET2 mutations are pathogenic in juvenile myelomonocytic leukemia. (20008299)
2010
11
CBL mutations in juvenile myelomonocytic leukemia and pediatric myelodysplastic syndrome. (20357823)
2010
12
Gene expression-based classification as an independent predictor of clinical outcome in juvenile myelomonocytic leukemia. (20231685)
2010
13
Infant juvenile myelomonocytic leukemia (JMML) with rapid infiltration of multiple organs. (20403038)
2010
14
Juvenile xanthogranuloma in a child with previously unsuspected neurofibromatosis type 1 and juvenile myelomonocytic leukemia. (19785027)
2010
15
Mutations in the let-7 binding site - a mechanism of RAS activation in juvenile myelomonocytic leukemia? (20460640)
2010
16
Correlation of clinical features with the mutational status of GM-CSF signaling pathway-related genes in juvenile myelomonocytic leukemia. (19047918)
2009
17
A rare finding of deletion 5q in a child with juvenile myelomonocytic leukemia. (19963125)
2009
18
Negative regulation of Stat3 by activating PTPN11 mutants contributes to the pathogenesis of Noonan syndrome and juvenile myelomonocytic leukemia. (19509418)
2009
19
Cytomegalovirus infection mimicking juvenile myelomonocytic leukemia showing hypersensitivity to granulocyte-macrophage colony stimulating factor. (19731324)
2009
20
Concomitant EBV-related B-cell proliferation and juvenile myelomonocytic leukemia in a 2-year-old child. (17618684)
2008
21
Juvenile myelomonocytic leukemia and chronic myelomonocytic leukemia. (18548091)
2008
22
Role of mutation independent constitutive activation of FLT3 in juvenile myelomonocytic leukemia. (18024405)
2007
23
Targeting RAS signaling pathways in juvenile myelomonocytic leukemia. (17584027)
2007
24
The role of splenectomy in children with juvenile myelomonocytic leukemia. (17907514)
2007
25
Mutation analysis of the BRAF oncogene in juvenile myelomonocytic leukemia. (18024410)
2007
26
Genome-wide single-nucleotide polymorphism analysis in juvenile myelomonocytic leukemia identifies uniparental disomy surrounding the NF1 locus in cases associated with neurofibromatosis but not in cases with mutant RAS or PTPN11. (17353900)
2007
27
Identification of an immunogenic CD8+ T-cell epitope derived from gamma-globin, a putative tumor-associated antigen for juvenile myelomonocytic leukemia. (16778141)
2006
28
Chromosomal change during 6-mercaptopurine (6-MP) therapy in juvenile myelomonocytic leukemia: the growth of a 6-MP-refractory clone that already exists at onset. (16424864)
2006
29
Pulmonary hypertension in a child with juvenile myelomonocytic leukemia secondary to pulmonary leukemic cell infiltration. (17065143)
2006
30
Does hematopoietic stem cell transplantation improve patient outcome in juvenile myelomonocytic leukemia? (16264985)
2005
31
Hematopoietic stem cell transplantation (HSCT) in children with juvenile myelomonocytic leukemia (JMML): results of the EWOG-MDS/EBMT trial. (15353481)
2005
32
The mutational spectrum of PTPN11 in juvenile myelomonocytic leukemia and Noonan syndrome/myeloproliferative disease. (15928039)
2005
33
Little response to zoledronic acid in a child of juvenile myelomonocytic leukemia (JMML) harboring the PTPN11 mutation. (15857842)
2005
34
Allogeneic bone marrow transplantation for juvenile myelomonocytic leukemia: a single center experience of 23 patients. (15654356)
2005
35
Donor leukocyte infusion after hematopoietic stem cell transplantation in patients with juvenile myelomonocytic leukemia. (15800672)
2005
36
A 3-bp deletion mutation of PTPN11 in an infant with severe Noonan syndrome including hydrops fetalis and juvenile myelomonocytic leukemia. (15211660)
2004
37
Allogeneic bone marrow transplantation in juvenile myelomonocytic leukemia without total body irradiation. (15125615)
2004
38
The International Prognostic Scoring System (IPSS) for childhood myelodysplastic syndrome (MDS) and juvenile myelomonocytic leukemia (JMML). (15496981)
2004
39
HCMOGT-1 is a novel fusion partner to PDGFRB in juvenile myelomonocytic leukemia with t(5;17)(q33;p11.2). (15087372)
2004
40
Acute parvovirus B19 infection mimicking juvenile myelomonocytic leukemia. (11073169)
2000
41
Extramedullary relapse despite graft-versus-leukemia effect after bone marrow transplantation in a girl with juvenile myelomonocytic leukemia. (10342589)
1999
42
Juvenile myelomonocytic leukemia and Noonan syndrome. (10598665)
1999
43
A case of juvenile myelomonocytic leukemia with ocular infiltration. (10647883)
1999
44
RAS mutations and clonality analysis in children with juvenile myelomonocytic leukemia (JMML). (10049057)
1999
45
Differentiating juvenile myelomonocytic leukemia from infectious disease. (9414312)
1998
46
Mutations of the NF1 gene in children with juvenile myelomonocytic leukemia without clinical evidence of neurofibromatosis, type 1. (9639526)
1998
47
Unbalanced t(3;12) in a case of juvenile myelomonocytic leukemia (JMML) results in partial trisomy of 3q as defined by FISH. (9305599)
1997
48
EVI-1 gene expression in myeloid clonogenic cells from juvenile myelomonocytic leukemia (JMML). (9447818)
1997
49
Interleukin (IL)-10, but not IL-4 or IL-13, inhibits cytokine production and growth in juvenile myelomonocytic leukemia cells. (9012477)
1997
50
Juvenile myelomonocytic leukemia: molecular understanding and prospects for therapy. (8947912)
1996

Variations for Juvenile Myelomonocytic Leukemia

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65UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar), 8dbSNP
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UniProtKB/Swiss-Prot genetic disease variations for Juvenile Myelomonocytic Leukemia:

65 (show all 12)
id Symbol AA change Variation ID SNP ID
1ARHGAP26p.Asn417SerVAR_013623
2PTPN11p.Asp61ValVAR_015991
3PTPN11p.Asp61TyrVAR_015992
4PTPN11p.Glu69LysVAR_015993
5PTPN11p.Ala72ThrVAR_015996
6PTPN11p.Ala72ValVAR_015997
7PTPN11p.Glu76AlaVAR_015998
8PTPN11p.Glu76GlyVAR_015999
9PTPN11p.Glu76LysVAR_016000rs28933388
10PTPN11p.Glu76ValVAR_016001
11PTPN11p.Gly507AlaVAR_016002
12SETBP1p.Asp868AsnVAR_063807

Clinvar genetic disease variations for Juvenile Myelomonocytic Leukemia:

1 (show all 11)
id Gene Name Type Significance SNP ID Assembly Location
1PTPN11NM_002834.3(PTPN11): c.218C> T (p.Thr73Ile)single nucleotide variantPathogenicrs121918462GRCh37Chr 12, 112888202: 112888202
2PTPN11NM_002834.3(PTPN11): c.226G> A (p.Glu76Lys)single nucleotide variantPathogenicrs121918464GRCh37Chr 12, 112888210: 112888210
3PTPN11NM_002834.3(PTPN11): c.227A> T (p.Glu76Val)single nucleotide variantPathogenicrs121918465GRCh37Chr 12, 112888211: 112888211
4PTPN11NM_002834.3(PTPN11): c.227A> G (p.Glu76Gly)single nucleotide variantPathogenicrs121918465GRCh37Chr 12, 112888211: 112888211
5PTPN11NM_002834.3(PTPN11): c.227A> C (p.Glu76Ala)single nucleotide variantPathogenicrs121918465GRCh37Chr 12, 112888211: 112888211
6NF1NM_000267.3(NF1): c.4614G> A (p.Trp1538Ter)single nucleotide variantPathogenicrs137854555GRCh37Chr 17, 29588828: 29588828
7NF1NF1, IVS34, G-A, +18single nucleotide variantPathogenic
8NF1NM_000267.3(NF1): c.1642-8A> Gsingle nucleotide variantPathogenicrs267606602GRCh37Chr 17, 29548860: 29548860
9ARHGAP26NM_015071.4(ARHGAP26): c.1250A> G (p.Asn417Ser)single nucleotide variantPathogenicrs121918546GRCh37Chr 5, 142421420: 142421420
10ARHGAP26ARHGAP26, 52-BP INSinsertionPathogenic
11ARHGAP26ARHGAP26, 74-BP INSinsertionPathogenic

Expression for genes affiliated with Juvenile Myelomonocytic Leukemia

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Juvenile Myelomonocytic Leukemia

Search GEO for disease gene expression data for Juvenile Myelomonocytic Leukemia.

Pathways for genes affiliated with Juvenile Myelomonocytic Leukemia

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Sources:
51PathCards, 31KEGG, 56Reactome, 39NCBI BioSystems Database, 52PharmGKB, 62Tocris Bioscience, 55R&D Systems, 61Thomson Reuters, 54QIAGEN
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Pathways related to Juvenile Myelomonocytic Leukemia according to GeneCards/GeneDecks:

(show top 50)    (show all 96)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7HRAS, NRAS, KRAS
2
Show member pathways
EGFR-dependent Endothelin signaling events39
9.7KRAS, HRAS, NRAS
3
Show member pathways
9.7NRAS, HRAS, KRAS
49.7NRAS, HRAS, KRAS
59.6CSF2, NF1, HRAS
6
Show member pathways
Insulin Pathway39
9.6HRAS, PTPN11, CBL
7
Show member pathways
9.4KRAS, PTPN11, HRAS, NRAS
8
Show member pathways
9.4NRAS, KRAS, HRAS, PTPN11
9
Show member pathways
9.4HRAS, KRAS, NRAS, PTPN11
109.4NRAS, KRAS, HRAS, PTPN11
119.4KRAS, HRAS, CBL, PTPN11
12
Show member pathways
IL-9 Signaling Pathway39
Development Thrombopoietin regulated cell processes61
IL-7 Signaling Pathway39
Immune response IL 9 signaling pathway61
9.4PTPN11, CBL, HRAS, KRAS
13
Show member pathways
9.4CBL, KRAS, HRAS, NRAS
14
Show member pathways
ErbB receptor signaling network39
ErbB signaling pathway39
9.4NRAS, HRAS, KRAS, CBL
15
Show member pathways
Development Flt3 signaling61
9.3HRAS, CBL, FLT3, PTPN11
16
Show member pathways
9.3HRAS, NRAS, CBL, FLT3
179.3HRAS, PDGFRA, NRAS, NF1
18
Show member pathways
9.3NRAS, KRAS, HRAS, PDGFRA
19
Show member pathways
9.3HRAS, KRAS, NRAS, PDGFRA
209.2HRAS, NRAS, CBL, KRAS, PTPN11
219.2HRAS, CBL, NRAS, KRAS, PTPN11
22
Show member pathways
9.2KRAS, NRAS, HRAS, CBL, PTPN11
23
Show member pathways
Prolactin Signaling Pathway39
Development Prolactin receptor signaling61
Leptin signaling pathway39
9.2PTPN11, KRAS, CBL, HRAS, NRAS
24
Show member pathways
MAPK signaling pathway39
9.1NRAS, HRAS, KRAS, PDGFRA, NF1
259.0RUNX1, FLT3, RARA, CSF2
26
Show member pathways
MAPK Cascade39
Immune response Oncostatin M signaling via MAPK in human cells61
Oncostatin M Signaling Pathway39
9.0NRAS, PTPN11, SIPA1, HRAS, KRAS
27
Show member pathways
Development EDNRB signaling61
Development ACM2 and ACM4 activation of ERK61
Cell adhesion Integrin inside out signaling61
Development G Proteins mediated regulation MARK ERK signaling61
Signal transduction IP3 signaling61
Development Angiotensin signaling via PYK261
Development EPO induced MAPK pathway61
9.0PDGFRA, HRAS, KRAS, CBL, NRAS
289.0HRAS, CSF2, PDGFRA, NRAS, KRAS
29
Show member pathways
9.0PDGFRA, NRAS, HRAS, KRAS, FLT3
30
Show member pathways
8.9CSF2, CBL, PTPN11, HRAS, NRAS, KRAS
31
Show member pathways
8.9PTPN11, CBL, CSF2, NRAS, HRAS, KRAS
32
Show member pathways
Immune response BCR pathway61
Fc-epsilon receptor I signaling in mast cells39
8.9CBL, CSF2, KRAS, HRAS, PTPN11, NRAS
33
Show member pathways
BCR signaling pathway39
TCR Signaling Pathway39
8.9HRAS, KRAS, NRAS, CSF2, CBL, PTPN11
34
Show member pathways
Immune response CD16 signaling in NK cells61
8.9NRAS, KRAS, CBL, PTPN11, HRAS, CSF2
358.9HRAS, KRAS, CBL, RARA, PTPN11
36
Show member pathways
8.8HRAS, KRAS, NRAS, CBL, PTPN11, RUNX1
37
Show member pathways
Signaling Pathways in Glioblastoma39
8.8KRAS, HRAS, CBL, PDGFRA, NRAS, NF1
38
Show member pathways
8.8KRAS, PDGFRA, CBL, PTPN11, HRAS, NRAS
39
Show member pathways
Transcription Receptor mediated HIF regulation61
Development CNTF receptor signaling61
Class IB PI3K non-lipid kinase events39
ErbB2/ErbB3 signaling events39
Development Growth hormone signaling via PI3K AKT and MAPK cascades61
Translation Regulation activity of EIF261
Regulation of lipid metabolism Insulin signaling generic cascades61
Transcription PPAR Pathway61
Cell adhesion PLAU signaling61
Translation Regulation activity of EIF4F61
8.8NRAS, CBL, PTPN11, HRAS, KRAS, PDGFRA
40
Show member pathways
Development EGFR signaling via PIP361
Development PDGF signaling via MAPK cascades61
Apoptosis and survival Anti apoptotic action of membrane bound ESR161
Signaling of Hepatocyte Growth Factor Receptor39
Development EGFR signaling via small GTPases61
Development Neurotrophin family signaling61
Apoptosis and survival NGF signaling pathway61
Apoptosis and survival Role of CDK5 in neuronal death and survival61
8.8PDGFRA, CBL, PTPN11, HRAS, KRAS, NRAS
41
Show member pathways
8.8PTPN11, CBL, HRAS, KRAS, NRAS, PDGFRA
42
Show member pathways
8.8HRAS, KRAS, NRAS, PDGFRA, PTPN11, CBL
438.7PDGFRA, DNMT3A, HRAS, NRAS, KRAS
44
Show member pathways
8.5PDGFRA, PTPN11, HRAS, NRAS, NF1, SIPA1
45
Show member pathways
8.4RARA, NRAS, PDGFRA, HRAS, FLT3, CSF2
46
Show member pathways
8.4CBL, PDGFRA, NRAS, SIPA1, KRAS, HRAS
478.3PDGFRA, BTD, PTPN11, KRAS, HRAS, CBL
48
Show member pathways
Signal transduction PTEN pathway61
8.2HRAS, KRAS, NRAS, CBL, RARA, FLT3
49
Show member pathways
7.9FLT3, RARA, CBL, PDGFRA, NRAS, HRAS
507.9HRAS, KRAS, NRAS, PDGFRA, CBL, FLT3

Compounds for genes affiliated with Juvenile Myelomonocytic Leukemia

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46Novoseek, 52PharmGKB, 12DrugBank, 62Tocris Bioscience, 30IUPHAR, 25HMDB
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Compounds related to Juvenile Myelomonocytic Leukemia according to GeneCards/GeneDecks:

(show top 50)    (show all 52)
idCompoundScoreTop Affiliating Genes
1pixy3214610.2CSF2, FLT3
2pkc 4124610.1PDGFRA, FLT3
3ag-12964610.1PDGFRA, FLT3
4idarubicin52 46 1212.1FLT3, CSF2
5ponatinib52 1210.9FLT3, PDGFRA
6methylcellulose469.8CSF2, FLT3, HBG1
7sunitinib46 52 1211.8PDGFRA, FLT3
8cytarabine46 52 1211.7CSF2, FLT3, HBG1
9gp 130469.7PTPN11, FLT3, CSF2, HRAS
10herbimycin a46 6210.7PTPN11, FLT3, CSF2, HRAS
11hydroxyurea46 52 1211.7PDGFRA, CSF2, HBG1
12cisplatin46 52 62 1212.6PTPN11, CSF2, KRAS, HRAS
13tgf beta1469.5FLT3, PDGFRA, RARA
14lysine469.5NF1, BTD, CBL, PTPN11
15wortmannin469.5PTPN11, CBL, CSF2, KRAS, HRAS
16ly294002469.5PTPN11, RARA, KRAS, HRAS
17phenylalanine469.5HRAS, BTD, CBL, PTPN11
18h2o2469.5PTPN11, CBL, CSF2, KRAS, HRAS
19phosphotyrosine469.4HRAS, PDGFRA, CBL, FLT3, PTPN11
2012-o-tetradecanoylphorbol 13-acetate469.4HRAS, RARA, CSF2, RUNX1
21threonine469.3RUNX1, PTPN11, FLT3, CBL, HRAS
22fatty acid469.3HBG1, BTD, NF1, KRAS
23valine469.3HRAS, KRAS, CSF2
24agar469.3PTPN11, CSF2, NRAS, RARA, HRAS
25etoposide46 52 62 1212.3RUNX1, PTPN11, FLT3, CSF2, RARA
26atp46 3010.2HRAS, NF1, PDGFRA, FLT3, PTPN11
27arsenite46 2510.2RUNX1, FLT3, RARA
28paraffin469.2PDGFRA, RARA, NF1, KRAS, HRAS
29doxorubicin46 52 1211.2HRAS, CSF2, FLT3, HBG1, RUNX1
305-aza-2deoxycytidine469.2DNMT3A, FLT3, HBG1
31aspartate469.1HRAS, RARA, PDGFRA, FLT3
32butyrate469.1RUNX1, HBG1, CSF2, RARA, KRAS
33alanine469.0PTPN11, CBL, BTD, RARA, NF1
34lipid469.0PTPN11, CBL, RARA, NF1, KRAS, HRAS
35phosphoinositide469.0PTPN11, FLT3, CBL, RARA, KRAS, HRAS
36arginine469.0PTPN11, BTD, RARA, NF1, HRAS
37rapamycin469.0PTPN11, FLT3, CBL, PDGFRA, NF1, KRAS
38folate469.0RARA, PDGFRA, DNMT3A
39oxygen46 259.9HRAS, KRAS, RARA, PTPN11, HBG1
40estrogen468.9CSF2, PDGFRA, RARA, NF1, KRAS, HRAS
41thymidine46 259.9PTPN11, FLT3, CSF2, PDGFRA, RARA, HRAS
42imatinib46 52 1210.7RUNX1, PTPN11, FLT3, CBL, PDGFRA, RARA
43cysteine468.5PTPN11, CBL, CSF2, BTD, RARA, NF1
44vegf468.3RUNX1, PTPN11, FLT3, CSF2, PDGFRA, RARA
45serine468.2RUNX1, PTPN11, CBL, BTD, RARA, NF1
46phosphatidylinositol468.2PTPN11, FLT3, CBL, CSF2, PDGFRA, RARA
47retinoic acid46 259.1RUNX1, FLT3, CBL, CSF2, PDGFRA, RARA
48zinc46 258.9RUNX1, HBG1, CBL, DNMT3A, BTD, RARA
49oligonucleotide467.5HRAS, RUNX1, PTPN11, FLT3, DNMT3A, PDGFRA
50tyrosine467.1RUNX1, PTPN11, FLT3, CBL, CSF2, PDGFRA

GO Terms for genes affiliated with Juvenile Myelomonocytic Leukemia

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Sources:
17Gene Ontology
See all sources

Cellular components related to Juvenile Myelomonocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:0056346.1HRAS, SPECC1, PTPN11, SETBP1, CBL, DNMT3A

Biological processes related to Juvenile Myelomonocytic Leukemia according to GeneCards/GeneDecks:

(show all 32)
idNameGO IDScoreTop Affiliating Genes
1myeloid progenitor cell differentiationGO:00231810.1FLT3, RUNX1
2dendritic cell differentiationGO:09702810.1FLT3, CSF2
3positive regulation of Rac protein signal transductionGO:03502210.0HRAS, KRAS, NRAS
4striated muscle cell differentiationGO:05114610.0HRAS, KRAS, NRAS
5activation of MAPKK activityGO:0001869.9NRAS, KRAS, HRAS
6positive regulation of MAP kinase activityGO:0434069.9FLT3, KRAS, HRAS
7negative regulation of granulocyte differentiationGO:0308539.9RARA, RUNX1
8regulation of synaptic transmission, GABAergicGO:0322289.9HRAS, KRAS, NF1, NRAS
9regulation of long-term neuronal synaptic plasticityGO:0481699.8NRAS, NF1, KRAS, HRAS
10visual learningGO:0085429.8HRAS, KRAS, NF1, NRAS
11positive regulation of phosphatidylinositol 3-kinase activityGO:0435529.8PDGFRA, FLT3
12MAPK cascadeGO:0001659.8NRAS, NF1, KRAS, HRAS
13Ras protein signal transductionGO:0072659.8HRAS, KRAS, NF1, NRAS
14positive regulation of DNA replicationGO:0457409.8HRAS, PDGFRA, CSF2
15leukocyte migrationGO:0509009.8HRAS, KRAS, NRAS, PTPN11
16insulin receptor signaling pathwayGO:0082869.8PTPN11, NRAS, KRAS, HRAS
17negative regulation of neuron apoptotic processGO:0435249.7NRAS, KRAS, HRAS
18liver developmentGO:0018899.7RUNX1, RARA, NF1
19actin cytoskeleton organizationGO:0300369.6NRAS, NF1, KRAS, HRAS, ARHGAP26
20adrenal gland developmentGO:0303259.6NF1, PDGFRA
21small GTPase mediated signal transductionGO:0072649.6ARHGAP26, HRAS, KRAS, NRAS
22GTP catabolic processGO:0061849.6HRAS, KRAS, NRAS
23axon guidanceGO:0074119.5HRAS, KRAS, NRAS, PTPN11
24Fc-epsilon receptor signaling pathwayGO:0380959.4PTPN11, PDGFRA, NRAS, KRAS, HRAS
25neurotrophin TRK receptor signaling pathwayGO:0480119.4PTPN11, PDGFRA, NRAS, KRAS, HRAS
26positive regulation of phosphatidylinositol 3-kinase signalingGO:0140689.4FLT3, CBL, PDGFRA, RARA
27positive regulation of ERK1 and ERK2 cascadeGO:0703749.3PDGFRA, RARA, HRAS
28innate immune responseGO:0450879.3HRAS, KRAS, NRAS, PDGFRA, PTPN11
29blood coagulationGO:0075969.3HRAS, KRAS, NRAS, PTPN11, HBG1
30fibroblast growth factor receptor signaling pathwayGO:0085439.2PTPN11, CBL, PDGFRA, NRAS, KRAS, HRAS
31epidermal growth factor receptor signaling pathwayGO:0071739.2PTPN11, CBL, PDGFRA, NRAS, KRAS, HRAS
32positive regulation of cell proliferationGO:0082848.6FLT3, CSF2, PDGFRA, NRAS, RARA, KRAS

Molecular functions related to Juvenile Myelomonocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1vascular endothelial growth factor-activated receptor activityGO:0050219.8FLT3, PDGFRA
2protein bindingGO:0055155.9RUNX1, PTPN11, FLT3, CBL, DNMT3A, CSF2

Products for genes affiliated with Juvenile Myelomonocytic Leukemia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Juvenile Myelomonocytic Leukemia

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet