JNA
MCID: JVN033
MIFTS: 39

Juvenile Nasopharyngeal Angiofibroma (JNA) malady

Categories: Rare diseases

Aliases & Classifications for Juvenile Nasopharyngeal Angiofibroma

Aliases & Descriptions for Juvenile Nasopharyngeal Angiofibroma:

Name: Juvenile Nasopharyngeal Angiofibroma 56
Nasopharyngeal Angiofibroma 69
Jna 56

Characteristics:

Orphanet epidemiological data:

56
juvenile nasopharyngeal angiofibroma
Inheritance: Not applicable; Age of onset: Adolescent,Childhood;

Classifications:



External Ids:

Orphanet 56 ORPHA289596
ICD10 via Orphanet 34 D10.6

Summaries for Juvenile Nasopharyngeal Angiofibroma

MalaCards based summary : Juvenile Nasopharyngeal Angiofibroma, also known as nasopharyngeal angiofibroma, is related to nasopharyngitis and bartholin's gland benign neoplasm, and has symptoms including dyspnea and headache. An important gene associated with Juvenile Nasopharyngeal Angiofibroma is VEGFA (Vascular Endothelial Growth Factor A), and among its related pathways/superpathways are Akt Signaling and Glioma. Affiliated tissues include endothelial and retina, and related phenotypes are Increased cell death HMECs cells and hematopoietic system

Related Diseases for Juvenile Nasopharyngeal Angiofibroma

Diseases related to Juvenile Nasopharyngeal Angiofibroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 94)
id Related Disease Score Top Affiliating Genes
1 nasopharyngitis 11.1
2 bartholin's gland benign neoplasm 10.3 ESR1 PGR
3 cardiovascular organ benign neoplasm 10.3 ESR1 PGR
4 appendix leiomyoma 10.3 ESR1 PGR
5 bronchus adenoma 10.3 ESR1 PGR
6 glioma 10.3 ESR1 PGR
7 ovarian benign neoplasm 10.3 ESR1 PGR
8 plexiform neurofibroma 10.3 ESR1 PGR
9 adult neuronal ceroid lipofuscinosis 10.3 ESR1 PGR VEGFA
10 tumor of exocrine pancreas 10.3 ESR1 FGF2 VEGFA
11 neurilemmoma of the pleura 10.3 FGF2 PGR VEGFA
12 benign idiopathic neonatal seizures 10.3 FGF2 PECAM1 VEGFA
13 paranasal sinus disease 10.3 ESR1 PGR
14 dental caries 10.3 ESR1 PGR VEGFA
15 nasal cavity disease 10.2 ESR1 PGR VEGFA
16 paraphimosis 10.2 ACTC1 ESR1 PGR
17 pericardium leiomyoma 10.2 ACTC1 PCNA PGR
18 osteoblastoma 10.2 ESR1 PGR TGFB3
19 secondary adrenal insufficiency 10.2 ACTC1 FGF2
20 atypical lipomatous tumor 10.2 ESR1 KIT PGR
21 vulva basal cell carcinoma 10.2 ESR1 KIT PGR
22 biliary tract neoplasm 10.2 ESR1 PGR TGFB3
23 middle ear adenocarcinoma 10.2 ESR1 KIT PGR
24 lymphomatous thyroiditis 10.2 PCNA PGR
25 rectal neoplasm 10.2 ESR1 KIT PGR
26 metagonimiasis 10.2 ESR1 FGF2 PGR VEGFA
27 prostatic adenoma 10.2 ESR1 FGF2 PGR VEGFA
28 arthus reaction 10.2 ESR1 KIT PGR
29 tooth erosion 10.2 ENG FGF2 VEGFA
30 skin angiosarcoma 10.2 KIT MYC PGR
31 her2-receptor negative breast cancer 10.2 CYP19A1 ESR1 PGR
32 osteogenesis imperfecta 10.2 CYP19A1 ESR1 PGR
33 fallopian tube carcinosarcoma 10.2 ESR1 MYC PGR VEGFA
34 acute thyroiditis 10.2 CYP19A1 ESR1 PGR
35 perinatal jaundice due to hepatocellular damage 10.2 CYP19A1 ESR1 PGR
36 trachea squamous cell carcinoma 10.2 ESR1 MYC PGR VEGFA
37 carbon monoxide-induced parkinsonism 10.2 ACTC1 KIT
38 endotheliitis 10.2
39 sebaceous adenoma 10.2 ACTC1 KIT PGR
40 hydrarthrosis 10.2 ACTC1 PGR
41 bardet-biedl syndrome 10.2 ESR1 MYC PGR VEGFA
42 esophagus sarcoma 10.2 CYP19A1 ESR1 PGR
43 nevoid hypermelanosis, linear and whorled 10.2 ESR1 FGF2 MYC VEGFA
44 pustulosis palmaris et plantaris 10.2 ACTC1 KIT PECAM1
45 capillary disease 10.2 CYP19A1 ESR1 PGR
46 breast duct papilloma 10.2 CYP19A1 ESR1 PGR
47 isolated anterior cervical hypertrichosis 10.2 ACTC1 VEGFA
48 fitz-hugh-curtis syndrome 10.2 ACTC1 KIT PGR
49 biemond syndrome 10.2 ACTC1 CYP19A1 PGR
50 progesterone-receptor negative breast cancer 10.2 CYP19A1 ESR1 PGR

Graphical network of the top 20 diseases related to Juvenile Nasopharyngeal Angiofibroma:



Diseases related to Juvenile Nasopharyngeal Angiofibroma

Symptoms & Phenotypes for Juvenile Nasopharyngeal Angiofibroma

UMLS symptoms related to Juvenile Nasopharyngeal Angiofibroma:


dyspnea, headache

GenomeRNAi Phenotypes related to Juvenile Nasopharyngeal Angiofibroma according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death HMECs cells GR00103-A-0 9.17 BMI1 BMP6 ENG MYC PCNA PGR

MGI Mouse Phenotypes related to Juvenile Nasopharyngeal Angiofibroma:

44 (show all 19)
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.4 VEGFA TLR7 TLR9 CYP11A1 ENG ESR1
2 cardiovascular system MP:0005385 10.39 VEGFA CYP11A1 ENG ESR1 CYP19A1 ACTC1
3 homeostasis/metabolism MP:0005376 10.39 VEGFA TLR7 TLR9 CYP11A1 ENG ESR1
4 cellular MP:0005384 10.38 TLR9 VEGFA TLR7 CYP11A1 CYP19A1 ACTC1
5 behavior/neurological MP:0005386 10.32 TLR3 VEGFA ENG CYP11A1 CYP19A1 FGF2
6 immune system MP:0005387 10.31 TLR9 VEGFA TLR7 CYP11A1 ESR1 CYP19A1
7 mortality/aging MP:0010768 10.3 TLR9 VEGFA TLR7 ENG CYP11A1 ACTC1
8 growth/size/body region MP:0005378 10.28 VEGFA BMP6 CYP19A1 ENG CYP11A1 ACTC1
9 digestive/alimentary MP:0005381 10.21 TLR9 VEGFA ENG CYP19A1 MYC ESR1
10 muscle MP:0005369 10.21 VEGFA CYP11A1 ENG ESR1 CYP19A1 ACTC1
11 endocrine/exocrine gland MP:0005379 10.2 TLR3 VEGFA CYP11A1 CYP19A1 KIT ESR1
12 nervous system MP:0003631 10.07 TLR3 VEGFA CYP19A1 ENG CYP11A1 ESR1
13 liver/biliary system MP:0005370 10.02 VEGFA CYP11A1 CYP19A1 KIT ESR1 PECAM1
14 normal MP:0002873 10.02 VEGFA ENG CYP11A1 CYP19A1 ACTC1 MYC
15 neoplasm MP:0002006 9.95 VEGFA FGF2 MYC ESR1 KIT TLR3
16 reproductive system MP:0005389 9.9 VEGFA CYP11A1 CYP19A1 BMP6 FGF2 MYC
17 renal/urinary system MP:0005367 9.8 TLR9 VEGFA TLR7 CYP19A1 ESR1 KIT
18 respiratory system MP:0005388 9.5 TLR3 VEGFA ENG ESR1 KIT TGFB3
19 skeleton MP:0005390 9.32 VEGFA CYP19A1 BMP6 FGF2 MYC ESR1

Drugs & Therapeutics for Juvenile Nasopharyngeal Angiofibroma

Search Clinical Trials , NIH Clinical Center for Juvenile Nasopharyngeal Angiofibroma

Genetic Tests for Juvenile Nasopharyngeal Angiofibroma

Anatomical Context for Juvenile Nasopharyngeal Angiofibroma

MalaCards organs/tissues related to Juvenile Nasopharyngeal Angiofibroma:

39
Endothelial, Retina

Publications for Juvenile Nasopharyngeal Angiofibroma

Articles related to Juvenile Nasopharyngeal Angiofibroma:

(show top 50) (show all 295)
id Title Authors Year
1
Adjunctive Treatment in Juvenile Nasopharyngeal Angiofibroma: How Should We Approach Recurrence? ( 26907644 )
2016
2
Current molecular profile of juvenile nasopharyngeal angiofibroma: First comprehensive study from India. ( 27577998 )
2016
3
The isolation and characterization of endothelial cells from juvenile nasopharyngeal angiofibroma. ( 27421657 )
2016
4
Endoscopic Radiofrequency Ablation-Assisted Resection of Juvenile Nasopharyngeal Angiofibroma: Comparison with Traditional Endoscopic Technique. ( 26932947 )
2016
5
Juvenile Nasopharyngeal Angiofibroma: A Rise in Incidence. ( 27340627 )
2016
6
Juvenile Nasopharyngeal Angiofibroma. ( 27164528 )
2016
7
Association between vascular supply, stage and tumour size of juvenile nasopharyngeal angiofibroma. ( 27289235 )
2016
8
Changing trends in the incidence of juvenile nasopharyngeal angiofibroma: seven decades of experience at King George's Medical University, Lucknow, India. ( 26864451 )
2016
9
Juvenile nasopharyngeal angiofibroma. ( 27601836 )
2016
10
Endoscopic Excision of Non-embolized Juvenile Nasopharyngeal Angiofibroma: Our Technique. ( 27508124 )
2016
11
Juvenile Nasopharyngeal Angiofibroma Presenting with Acute Airway Obstruction. ( 27752379 )
2016
12
In defence of transpalatal, transpalatal-circumaxillary (transpterygopalatine) and transpalatal-circumaxillary-sublabial approaches to lateral extensions of juvenile nasopharyngeal angiofibroma. ( 26940398 )
2016
13
Current status and clinical association of beta-catenin with juvenile nasopharyngeal angiofibroma. ( 27572281 )
2016
14
A Drastic Aftermath of Embolisation in Juvenile Nasopharyngeal Angiofibroma. ( 27833886 )
2016
15
Time trends in recurrence of juvenile nasopharyngeal angiofibroma: Experience of the past 4 decades. ( 27178522 )
2016
16
Human Papilloma virus in Juvenile Nasopharyngeal Angiofibroma: possible recent trend. ( 27157983 )
2016
17
Long-term treatment outcomes of juvenile nasopharyngeal angiofibroma treated with radiotherapy. ( 26019389 )
2015
18
Combined percutaneous and transarterial devascularisation of juvenile nasopharyngeal angiofibroma with protection of internal carotid artery: A modification of the technique. ( 25991005 )
2015
19
Toll-like receptors 3, 7, and 9 in Juvenile nasopharyngeal angiofibroma. ( 25912131 )
2015
20
Endoscopic graduated multiangle, multicorridor resection of juvenile nasopharyngeal angiofibroma: an individualized, tailored, multicorridor skull base approach. ( 26566205 )
2015
21
Juvenile nasopharyngeal angiofibroma staging: An overview. ( 26053985 )
2015
22
Clinical Characteristics of Recurrent Juvenile Nasopharyngeal Angiofibroma (JNA) After Radiation Therapy. ( 26693464 )
2015
23
Juvenile nasopharyngeal angiofibroma: comparison between endoscopic and open operative approaches. ( 25974801 )
2015
24
Bilateral, independent juvenile nasopharyngeal angiofibroma: case report. ( 26314415 )
2015
25
Management of advanced intracranial intradural juvenile nasopharyngeal angiofibroma: combined single-stage rhinosurgical and neurosurgical approach. ( 25778926 )
2015
26
Vision Loss due to Central Retinal Artery Occlusion Following Embolization in a Case of a Giant Juvenile Nasopharyngeal Angiofibroma. ( 26167999 )
2015
27
Juvenile Nasopharyngeal Angiofibroma: Case report with review on role of imaging in diagnosis. ( 25684921 )
2015
28
Preoperative Embolization to Improve the Surgical Management and Outcome of Juvenile Nasopharyngeal Angiofibroma (JNA) in a Single Center: 10-Year Experience. ( 25630469 )
2015
29
Do open and endoscopic resection approaches to juvenile nasopharyngeal angiofibroma result in similar blood loss and recurrence rates? ( 26154365 )
2015
30
Juvenile Nasopharyngeal Angiofibroma Extending into the Oral Cavity: A Rare Entity. ( 26266232 )
2015
31
Detection of the source of hemorrhage using postmortem computerized tomographic angiography in a case of a giant juvenile nasopharyngeal angiofibroma after surgical treatment. ( 26213386 )
2015
32
Juvenile nasopharyngeal angiofibroma presenting as a palatal swelling. ( 25198952 )
2014
33
Bilateral juvenile nasopharyngeal angiofibroma: report of a case. ( 24664618 )
2014
34
The presence of tumor-infiltrating IL-17-producing cells in juvenile nasopharyngeal angiofibroma tumor microenvironment is a poor prognostic factor. ( 25014998 )
2014
35
Stridor: an unusual presentation of juvenile nasopharyngeal angiofibroma. ( 24711471 )
2014
36
Two types of lateral extension in juvenile nasopharyngeal angiofibroma: diagnostic and therapeutic management. ( 24599598 )
2014
37
Surgery for juvenile nasopharyngeal angiofibroma with lateral extension to the infratemporal fossa. ( 24685728 )
2014
38
Complications in the endoscopic and endoscopic-assisted treatment of juvenile nasopharyngeal angiofibroma with intracranial extension. ( 24830969 )
2014
39
Fully endoscopic resection of juvenile nasopharyngeal angiofibroma - own experience and clinical outcomes. ( 24809773 )
2014
40
Hormonal receptors and vascular endothelial growth factor in juvenile nasopharyngeal angiofibroma: immunohistochemical and tissue microarray analysis. ( 25384380 )
2014
41
Microspheres embolization of juvenile nasopharyngeal angiofibroma in an adult. ( 25437676 )
2014
42
Prognostic value of matrix metalloproteinase 9 expression in patients with juvenile nasopharyngeal angiofibroma: tissue microarray analysis. ( 24969348 )
2014
43
Juvenile nasopharyngeal angiofibroma resection- novel technique to improve posterior/inferior margin control. ( 24108672 )
2013
44
Juvenile Nasopharyngeal Angiofibroma: diagnosis and surgical treatment in I and II stage with dento-alveolar involvement. ( 24353791 )
2013
45
Surgical management of juvenile nasopharyngeal angiofibroma: Analysis of 162 cases 1995-2012. ( 24222212 )
2013
46
Juvenile nasopharyngeal angiofibroma: a systematic review and comparison of endoscopic, endoscopic-assisted, and open resection in 1047 cases. ( 23483486 )
2013
47
Use of coblation in resection of juvenile nasopharyngeal angiofibroma. ( 23837385 )
2013
48
Molecular pathogenesis of juvenile nasopharyngeal angiofibroma in brazilian patients. ( 23802802 )
2013
49
Juvenile nasopharyngeal angiofibroma: Vascular determinates for operative complications and tumor recurrence. ( 23929652 )
2013
50
Endonasal endoscopic management of juvenile nasopharyngeal angiofibroma without angiographic embolization. ( 23271032 )
2013

Variations for Juvenile Nasopharyngeal Angiofibroma

Expression for Juvenile Nasopharyngeal Angiofibroma

Search GEO for disease gene expression data for Juvenile Nasopharyngeal Angiofibroma.

Pathways for Juvenile Nasopharyngeal Angiofibroma

Pathways related to Juvenile Nasopharyngeal Angiofibroma according to GeneCards Suite gene sharing:

(show all 29)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.33 BMP6 FGF2 KIT TGFB3 TLR3 TLR7
2
Show member pathways
12.93 ESR1 FGF2 KIT MYC PGR VEGFA
3
Show member pathways
12.78 MYC PCNA TGFB3 TLR3 TLR7 TLR9
4 12.59 FGF2 KIT MYC TGFB3 VEGFA
5 12.4 KIT PECAM1 TLR3 TLR7 TLR9
6
Show member pathways
12.35 BMP6 FGF2 TGFB3 TLR3 TLR7 TLR9
7
Show member pathways
12.27 KIT MYC PCNA TGFB3
8 12.21 ESR1 FGF2 MYC VEGFA
9 12.04 CYP19A1 ESR1 MYC VEGFA
10 11.93 PCNA TLR3 TLR7 TLR9
11 11.91 BMI1 FGF2 MYC VEGFA
12 11.74 TLR3 TLR7 TLR9
13
Show member pathways
11.74 TGFB3 TLR3 TLR7 TLR9
14 11.73 BMP6 MYC TGFB3
15 11.71 BMI1 FGF2 VEGFA
16 11.71 ENG ESR1 MYC TGFB3
17 11.68 KIT TLR7 TLR9
18
Show member pathways
11.64 ESR1 KIT MYC VEGFA
19 11.6 BMP6 FGF2 VEGFA
20 11.56 ENG FGF2 PECAM1 TGFB3
21 11.48 ACTC1 FGF2 KIT
22 11.45 BMP6 CYP11A1 CYP19A1
23 11.43 PECAM1 TGFB3 TLR9
24 11.42 ESR1 MYC VEGFA
25 11.34 BMP6 ENG FGF2 KIT TGFB3
26 11.32 MYC TGFB3 TLR3 TLR7 TLR9 VEGFA
27 11.14 FGF2 KIT TGFB3 VEGFA
28 11.05 FGF2 TGFB3 VEGFA
29 10.14 CYP19A1 ESR1

GO Terms for Juvenile Nasopharyngeal Angiofibroma

Cellular components related to Juvenile Nasopharyngeal Angiofibroma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.65 ENG KIT TGFB3 TLR3 VEGFA
2 extracellular space GO:0005615 9.61 ACTC1 BMP6 ENG FGF2 KIT PECAM1
3 early phagosome GO:0032009 9.16 TLR7 TLR9
4 endolysosome membrane GO:0036020 8.8 TLR3 TLR7 TLR9

Biological processes related to Juvenile Nasopharyngeal Angiofibroma according to GeneCards Suite gene sharing:

(show all 35)
id Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.99 BMP6 KIT TLR3 TLR7 TLR9
2 negative regulation of gene expression GO:0010629 9.9 ENG ESR1 MYC PGR
3 response to estradiol GO:0032355 9.83 ESR1 MYC PCNA
4 wound healing GO:0042060 9.81 FGF2 PECAM1 TGFB3
5 BMP signaling pathway GO:0030509 9.81 BMP6 ENG TGFB3
6 positive regulation of endothelial cell proliferation GO:0001938 9.8 BMP6 FGF2 VEGFA
7 positive regulation of epithelial cell proliferation GO:0050679 9.79 BMP6 MYC VEGFA
8 positive regulation of MAP kinase activity GO:0043406 9.79 FGF2 KIT VEGFA
9 positive regulation of inflammatory response GO:0050729 9.78 TLR3 TLR7 TLR9
10 positive regulation of fibroblast proliferation GO:0048146 9.76 BMI1 ESR1 MYC
11 cellular response to mechanical stimulus GO:0071260 9.76 BMP6 ENG TLR3 TLR7
12 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.75 BMP6 ENG TGFB3
13 positive regulation of cell division GO:0051781 9.74 FGF2 TGFB3 VEGFA
14 toll-like receptor signaling pathway GO:0002224 9.73 TLR3 TLR7 TLR9
15 positive regulation of interleukin-6 production GO:0032755 9.72 TLR3 TLR7 TLR9
16 ovarian follicle development GO:0001541 9.71 KIT MYC VEGFA
17 positive regulation of gene expression GO:0010628 9.7 ACTC1 ENG KIT MYC TLR3 TLR9
18 positive regulation of interleukin-8 production GO:0032757 9.69 TLR3 TLR7 TLR9
19 uterus development GO:0060065 9.67 CYP19A1 ESR1
20 toll-like receptor 9 signaling pathway GO:0034162 9.66 TLR7 TLR9
21 cell migration involved in sprouting angiogenesis GO:0002042 9.65 FGF2 VEGFA
22 cellular response to estrogen stimulus GO:0071391 9.65 ESR1 MYC
23 positive regulation of NF-kappaB import into nucleus GO:0042346 9.65 TLR3 TLR7 TLR9
24 microglial cell activation GO:0001774 9.64 TLR3 TLR7
25 positive regulation of SMAD protein import into nucleus GO:0060391 9.63 BMP6 TGFB3
26 positive regulation of chemokine production GO:0032722 9.61 TLR3 TLR7 TLR9
27 positive regulation of interferon-gamma biosynthetic process GO:0045078 9.58 TLR3 TLR7 TLR9
28 I-kappaB phosphorylation GO:0007252 9.54 TLR3 TLR7 TLR9
29 positive regulation of toll-like receptor signaling pathway GO:0034123 9.52 TLR3 TLR9
30 positive regulation of phospholipase C activity GO:0010863 9.5 ESR1 FGF2 KIT
31 positive regulation of vascular smooth muscle cell differentiation GO:1905065 9.49 ENG KIT
32 positive regulation of interferon-beta biosynthetic process GO:0045359 9.43 TLR3 TLR7 TLR9
33 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.32 BMP6 ENG ESR1 FGF2 MYC PGR
34 positive regulation of interferon-alpha biosynthetic process GO:0045356 9.13 TLR3 TLR7 TLR9
35 signal transduction GO:0007165 10.26 ESR1 FGF2 KIT PECAM1 PGR TLR3

Molecular functions related to Juvenile Nasopharyngeal Angiofibroma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transmembrane signaling receptor activity GO:0004888 9.67 ENG TLR3 TLR7 TLR9
2 cytokine activity GO:0005125 9.56 BMP6 FGF2 TGFB3 VEGFA
3 type I transforming growth factor beta receptor binding GO:0034713 9.32 ENG TGFB3
4 siRNA binding GO:0035197 9.16 TLR7 TLR9
5 type II transforming growth factor beta receptor binding GO:0005114 8.96 ENG TGFB3
6 growth factor activity GO:0008083 8.92 BMP6 FGF2 TGFB3 VEGFA

Sources for Juvenile Nasopharyngeal Angiofibroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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