JNA
MCID: JVN033
MIFTS: 39

Juvenile Nasopharyngeal Angiofibroma (JNA) malady

Cancer diseases category

Summaries for Juvenile Nasopharyngeal Angiofibroma

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MalaCards: Juvenile Nasopharyngeal Angiofibroma, also known as JNA, is related to familial adenomatous polyposis and fibrosarcoma. An important gene associated with Juvenile Nasopharyngeal Angiofibroma is BMI1 (BMI1 polycomb ring finger oncogene), and among its related pathways are Glypican 1 network and Glioma. The compounds matrigel and steroid have been mentioned in the context of this disorder. Related mouse phenotypes are limbs/digits/tail and renal/urinary system.

Aliases & Classifications for Juvenile Nasopharyngeal Angiofibroma

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48Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

juvenile nasopharyngeal angiofibroma 48
jna 48


External Ids:

ICD10 via Orphanet26 D10.6

Related Diseases for Juvenile Nasopharyngeal Angiofibroma

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17GeneCards, 18GeneDecks
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Diseases related to Juvenile Nasopharyngeal Angiofibroma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 185)
idRelated DiseaseScoreTop Affiliating Genes
1familial adenomatous polyposis30.7CDH1, MYC, CTNNB1
2fibrosarcoma30.4ACTC1, FGF2
3nasopharyngitis11.5
4nasopharyngeal disease10.4
5retinitis10.4
6central retinal artery occlusion10.3
7foster-kennedy syndrome10.3
8fibrous histiocytoma10.3
9carotid artery occlusion10.3
10alopecia10.3
11esotropia10.3
12histiocytoma10.3
13retinal artery occlusion10.3
14liver cirrhosis10.0TGFB3
15angiosarcoma10.0ACTC1
16pheochromocytoma10.0H19
17germ cell tumors10.0KIT
18cataract10.0TGFB3
19uterine carcinosarcoma10.0KIT
20fasciitis10.0ACTC1
21paraganglioma10.0KIT
22cleft palate10.0TGFB3
23severe combined immunodeficiency10.0ZAP70
24esophageal cancer10.0CDH1
25stomach cancer10.0CDH1
26gastrointestinal system disease10.0CDH1
27neuroblastoma10.0MYC
28cholangiocarcinoma10.0CDH1
29craniopharyngioma10.0CTNNB1
30nephroblastoma10.0CTNNB1
31sertoli cell tumor10.0PGR
32anaplastic large cell lymphoma10.0ZAP70
33galactosemia10.0PCNA
34hypoglycemia10.0IGF2
35hypertrophic cardiomyopathy10.0ACTC1
36oligodendroglioma10.0PCNA
37polycystic ovary syndrome10.0IGF2
38asthma10.0TGFB3, ZAP70
39acute leukemia10.0KIT, BMI1
40leukoplakia10.0PCNA
41myelodysplastic syndromes10.0KIT, BMI1
42carney triad10.0KIT
43arthritis10.0FGF2
44hypoglycemic coma10.0IGF2
45infertility10.0ESR1
46cerebral meningioma10.0PGR
47prolactinoma10.0ESR1
48actinic keratosis10.0PCNA
49neurofibroma10.0ACTC1, KIT
50chondrosarcoma10.0FGF2

Graphical network of the top 20 diseases related to Juvenile Nasopharyngeal Angiofibroma:



Diseases related to juvenile nasopharyngeal angiofibroma

Clinical Features for Juvenile Nasopharyngeal Angiofibroma

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Drugs & Therapeutics for Juvenile Nasopharyngeal Angiofibroma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Juvenile Nasopharyngeal Angiofibroma

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Anatomical Context for Juvenile Nasopharyngeal Angiofibroma

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Animal Models for Juvenile Nasopharyngeal Angiofibroma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Juvenile Nasopharyngeal Angiofibroma:

36 (show all 25)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537110.4H19, BMI1
2MP:000536710.2H19
3MP:00036319.7MYC, KIT, BMI1
4MP:00053799.7MYC, KIT, H19, BMI1
5MP:00053809.5H19, PGR, ENG, TGFB3
6MP:00053919.4H19, TGFB3, FGF2
7MP:00020069.2BMI1, CTNNB1, KIT, H19, CDH1, PGR
8MP:00053768.9ESR1, ACTC1, PGR, TGFB3, IGF2, H19
9MP:00053908.7VEGFA, MYC, PGR, H19, FGF2, TGFB3
10MP:00030128.6KIT, PGR, CDH1, MYC, IGF2, CTNNB1
11MP:00053888.1VEGFA, ENG, ESR1, TGFB3, IGF2, BMI1
12MP:00107718.1ENG, CDH1, MYC, IGF2, VEGFA, ZAP70
13MP:00053698.0ENG, MYC, ACTC1, H19, ESR1, FGF2
14MP:00053898.0CTNNB1, PCNA, CDH1, MYC, BMP6, VEGFA
15MP:00053707.8H19, KIT, MYC, IGF2, VEGFA, CTNNB1
16MP:00053827.7BMI1, CTNNB1, ENG, VEGFA, H19, KIT
17MP:00053817.6MYC, TGFB3, ESR1, IGF2, VEGFA, BMI1
18MP:00028737.2ACTC1, PGR, CDH1, MYC, ZAP70, BMI1
19MP:00053866.9ESR1, KIT, PGR, FGF2, MYC, BMI1
20MP:00053876.6BMI1, VEGFA, IGF2, MYC, CDH1, PCNA
21MP:00053856.0ESR1, ENG, ACTC1, KIT, PGR, FGF2
22MP:00053975.9PCNA, MYC, CTNNB1, ZAP70, KIT, PGR
23MP:00053785.7IGF2, MYC, CDH1, PCNA, ENG, BMI1
24MP:00107685.1PCNA, BMI1, H19, TGFB3, ESR1, ENG
25MP:00053845.0BMI1, FGF2, PCNA, CDH1, MYC, IGF2

Publications for Juvenile Nasopharyngeal Angiofibroma

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Genetic Variations for Juvenile Nasopharyngeal Angiofibroma

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Expression for genes affiliated with Juvenile Nasopharyngeal Angiofibroma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Juvenile Nasopharyngeal Angiofibroma

Search GEO for disease gene expression data for Juvenile Nasopharyngeal Angiofibroma.

Pathways for genes affiliated with Juvenile Nasopharyngeal Angiofibroma

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37NCBI BioSystems Database, 29KEGG, 53Reactome, 51QIAGEN, 12EMD Millipore, 4Cell Signaling Technology, 52R&D Systems
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Pathways related to Juvenile Nasopharyngeal Angiofibroma according to GeneCards/GeneDecks:

(show all 43)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3TGFB3
2
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10.1MYC
39.9CDH1, CTNNB1
49.9CDH1, CTNNB1
59.8MYC, CTNNB1
6
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9.8IGF2, CDH1
7
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9.7ZAP70, KIT, TGFB3
8
Development Slit-Robo signaling
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9.6CTNNB1, CDH1, ACTC1
99.6CTNNB1, CDH1, ACTC1
109.5CTNNB1, MYC, CDH1
119.5MYC, IGF2, CTNNB1
12
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9.5TGFB3, MYC, VEGFA
13
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9.4TGFB3, IGF2, VEGFA
149.4BMP6, MYC, TGFB3
159.3TGFB3, CDH1, MYC, CTNNB1
16
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9.3KIT, FGF2, CTNNB1
179.2VEGFA, BMP6, CTNNB1
18
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9.2CTNNB1, BMP6, KIT, TGFB3
19
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9.1TGFB3, IGF2, ZAP70, BMP6
20
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9.1TGFB3, PCNA, CDH1
219.1FGF2, ENG, TGFB3
229.0PCNA, MYC, CTNNB1
239.0IGF2, FGF2, KIT, ACTC1
249.0TGFB3, ESR1, ENG, MYC
25
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8.9IGF2, MYC, PCNA
26
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8.9FGF2, PGR, KIT, ESR1
278.9CTNNB1, MYC, CDH1, FGF2
288.7CTNNB1, MYC, ENG, ESR1, TGFB3
29
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8.6CTNNB1, VEGFA, MYC, CDH1, ESR1
308.6CTNNB1, VEGFA, MYC, CDH1, ESR1
31
Cell cycle Cell cycle (generic schema)
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8.6MYC, PCNA, PGR, ESR1
32
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8.5CTNNB1, BMP6, FGF2, KIT, TGFB3
338.5BMP6, VEGFA, IGF2, FGF2
34
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8.5BMP6, ZAP70, IGF2, FGF2, TGFB3
35
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8.4CTNNB1, MYC, CDH1, PCNA, KIT
36
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8.2BMP6, ZAP70, IGF2, FGF2, KIT, TGFB3
378.0CTNNB1, VEGFA, IGF2, MYC, FGF2, ESR1
387.9CTNNB1, VEGFA, MYC, CDH1, FGF2, KIT
39
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7.9BMP6, ZAP70, IGF2, MYC, FGF2, KIT
40
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7.7BMP6, ZAP70, IGF2, MYC, FGF2, ESR1
417.5CTNNB1, VEGFA, MYC, PCNA, FGF2, ESR1
42
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7.1CTNNB1, VEGFA, IGF2, MYC, CDH1, FGF2
43
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6.8TGFB3, CTNNB1, BMP6, ZAP70, IGF2, MYC

Compounds for genes affiliated with Juvenile Nasopharyngeal Angiofibroma

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44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 24HMDB, 2BitterDB
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Compounds related to Juvenile Nasopharyngeal Angiofibroma according to GeneCards/GeneDecks:

(show top 50)    (show all 164)
idCompoundScoreTop Affiliating Genes
1matrigel4410.0CTNNB1, CDH1, ACTC1
2steroid449.7TGFB3, ESR1, ACTC1, H19
3tamoxifen44 49 28 1112.6CTNNB1, IGF2, CDH1, PGR
4triphenylethylene449.5BMP6, PGR, ESR1
5suramin44 28 1111.5IGF2, PCNA
6sodium dodecylsulfate449.4PGR, MYC, BMP6
7dfmo44 59 2811.4CTNNB1, IGF2, MYC, CDH1
8trastuzumab44 49 1111.1CTNNB1, VEGFA, PGR, KIT, ESR1
9methylcellulose448.9CTNNB1, IGF2, CDH1, FGF2, KIT
10heparin44 28 11 2411.9BMP6, ZAP70, VEGFA, CDH1
11glutamine448.9PCNA, CDH1, IGF2, CTNNB1
12danazol44 11 2410.9CDH1, PCNA, PGR, ESR1
13indomethacin44 59 28 1111.9IGF2, PCNA, PGR
14su6668448.8KIT, FGF2, VEGFA
15geldanamycin44 49 59 1111.8CTNNB1, VEGFA, CDH1, PGR, KIT, ESR1
16progestin448.8VEGFA, IGF2, CDH1, PGR, ESR1, TGFB3
17docetaxel44 49 59 1111.8VEGFA, MYC, CDH1, PGR, KIT, ESR1
185fluorouracil448.7CTNNB1, CDH1, PCNA, PGR, KIT, TGFB3
19glycosaminoglycan448.6BMP6, IGF2, FGF2, ACTC1, TGFB3
20dihydrotestosterone44 28 11 2411.5BMP6, FGF2, PGR, ENG, ESR1
21retinoid448.5ESR1, PGR, CDH1, MYC, BMP6, CTNNB1
224-hydroxytamoxifen448.4CTNNB1, BMP6, IGF2, MYC, PGR, ESR1
23ribonucleic acid448.4H19, BMP6, IGF2, MYC, PGR, KIT
24celecoxib44 59 28 49 11 2413.3CTNNB1, VEGFA, CDH1, PCNA, FGF2
25rapamycin448.2CTNNB1, BMP6, VEGFA, IGF2, MYC, CDH1
26pd 98,059448.2CTNNB1, BMP6, ZAP70, MYC, CDH1, FGF2
27mg 13244 599.2CTNNB1, VEGFA, MYC, CDH1, PCNA, ESR1
28imatinib44 49 1110.2CTNNB1, BMP6, ZAP70, VEGFA, IGF2, MYC
29methotrexate44 49 1110.1BMP6, CDH1, PCNA, PGR, KIT, ESR1
30gefitinib44 49 1110.1CTNNB1, VEGFA, IGF2, CDH1, FGF2, KIT
31hyaluronic acid44 249.0BMP6, VEGFA, MYC, CDH1, FGF2, ENG
32tgf beta1448.0CTNNB1, BMP6, IGF2, CDH1, FGF2, ENG
33paclitaxel44 49 119.9CTNNB1, BMP6, VEGFA, IGF2, MYC, CDH1
34tyrosine447.7H19, CTNNB1, ZAP70, VEGFA, IGF2, MYC
35phosphatidylinositol447.6CTNNB1, BMP6, ZAP70, IGF2, MYC, CDH1
36testosterone44 59 11 2410.6CTNNB1, IGF2, CDH1, PCNA, PGR, KIT
37cisplatin44 49 59 1110.5CTNNB1, BMP6, VEGFA, IGF2, MYC, CDH1
38ly294002447.5CTNNB1, BMP6, VEGFA, IGF2, MYC, CDH1
39doxorubicin44 49 119.5CTNNB1, BMP6, VEGFA, MYC, CDH1, PGR
40agar447.4H19, CTNNB1, BMP6, IGF2, MYC, CDH1
415-aza-2deoxycytidine447.3PCNA, PGR, ESR1, CDH1, MYC, IGF2
42oligonucleotide447.2CTNNB1, BMP6, ZAP70, IGF2, MYC, PCNA
43genistein44 28 59 2 11 2412.1CTNNB1, ZAP70, VEGFA, MYC, CDH1, PCNA
44thymidine44 247.9H19, CTNNB1, BMP6, ZAP70, IGF2, MYC
45alanine446.9BMP6, IGF2, MYC, CDH1, PCNA, FGF2
46progesterone44 59 28 11 2410.6CTNNB1, BMP6, IGF2, CDH1, PCNA, PGR
47dexamethasone44 49 28 119.2MYC, CDH1, PCNA, FGF2, ENG, TGFB3
48retinoic acid44 246.9H19, CTNNB1, BMP6, TGFB3, ESR1, ACTC1
49paraffin445.5H19, CTNNB1, VEGFA, IGF2, MYC, CDH1
50vegf445.2MYC, CDH1, PCNA, FGF2, PGR, KIT

GO Terms for genes affiliated with Juvenile Nasopharyngeal Angiofibroma

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16Gene Ontology
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Cellular components related to Juvenile Nasopharyngeal Angiofibroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1catenin complexGO:0163429.6CTNNB1, CDH1
2platelet alpha granule lumenGO:0310939.3TGFB3, IGF2, VEGFA
3extracellular spaceGO:0056157.5TGFB3, BMP6, VEGFA, IGF2, FGF2, KIT
4cytoplasmGO:0057376.6BMI1, BMP6, ZAP70, VEGFA, CDH1, PCNA

Biological processes related to Juvenile Nasopharyngeal Angiofibroma according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1regulation of protein localization to cell surfaceGO:200000810.1CTNNB1, CDH1
2cellular response to indole-3-methanolGO:07168110.1CTNNB1, CDH1
3detection of hypoxiaGO:07048310.1ENG, TGFB3
4central nervous system vasculogenesisGO:02200910.0ENG, CTNNB1
5positive regulation of protein phosphorylationGO:0019349.9VEGFA
6positive regulation of fibroblast proliferationGO:0481469.8BMI1, MYC, ESR1
7positive regulation of endothelial cell differentiationGO:0456039.8BMP6, CTNNB1
8positive regulation of MAPK cascadeGO:0434109.7KIT, IGF2, CTNNB1
9positive regulation of mesenchymal cell proliferationGO:0020539.7CTNNB1, VEGFA, MYC
10positive regulation of pathway-restricted SMAD protein phosphorylationGO:0108629.6TGFB3, ENG, BMP6
11positive regulation of phospholipase C activityGO:0108639.5ESR1, KIT, FGF2
12patterning of blood vesselsGO:0015699.5CTNNB1, VEGFA, ENG
13branching involved in ureteric bud morphogenesisGO:0016589.5FGF2, MYC, CTNNB1
14platelet degranulationGO:0025769.5TGFB3, IGF2, VEGFA
15cell migration involved in sprouting angiogenesisGO:0020429.4FGF2, VEGFA
16positive regulation of epithelial cell proliferationGO:0506799.4BMP6, VEGFA, MYC
17response to drugGO:0424939.3CTNNB1, MYC, CDH1, ACTC1
18positive regulation of osteoblast differentiationGO:0456699.3CTNNB1, BMP6, FGF2
19positive regulation of cell divisionGO:0517819.2VEGFA, IGF2, FGF2, TGFB3
20positive regulation of endothelial cell proliferationGO:0019389.1FGF2, VEGFA, BMP6
21activation of MAPK activityGO:0001879.1TGFB3, KIT, FGF2
22positive regulation of transcription, DNA-dependentGO:0458938.9CTNNB1, MYC, CDH1, FGF2, TGFB3
23negative regulation of transcription from RNA polymerase II promoterGO:0001228.8CTNNB1, BMI1, VEGFA, MYC, ENG
24positive regulation of cell proliferationGO:0082848.7VEGFA, IGF2, MYC, FGF2, KIT
25positive regulation of transcription from RNA polymerase II promoterGO:0459447.4TGFB3, CTNNB1, BMP6, VEGFA, MYC, FGF2

Molecular functions related to Juvenile Nasopharyngeal Angiofibroma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transforming growth factor beta bindingGO:0504319.7TGFB3, ENG
2type I transforming growth factor beta receptor bindingGO:0347139.6TGFB3, ENG
3type II transforming growth factor beta receptor bindingGO:0051149.4TGFB3, ENG
4growth factor activityGO:0080838.3BMP6, VEGFA, IGF2, FGF2, TGFB3
5protein bindingGO:0055155.1IGF2, ZAP70, BMI1, CTNNB1, MYC, CDH1

Products for genes affiliated with Juvenile Nasopharyngeal Angiofibroma

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Sources for Juvenile Nasopharyngeal Angiofibroma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet