JNA
MCID: JVN033
MIFTS: 39

Juvenile Nasopharyngeal Angiofibroma (JNA) malady

Category: Rare diseases

Aliases & Classifications for Juvenile Nasopharyngeal Angiofibroma

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Sources:
31ICD10 via Orphanet, 54Orphanet, 68UMLS
See all MalaCards sources

Aliases & Descriptions for Juvenile Nasopharyngeal Angiofibroma:

Name: Juvenile Nasopharyngeal Angiofibroma 54
Nasopharyngeal Angiofibroma 68
 
Jna 54

Characteristics:

Orphanet epidemiological data:

54
juvenile nasopharyngeal angiofibroma:
Inheritance: Not applicable; Age of onset: Adolescent,Childhood

Classifications:



External Ids:

Orphanet54 ORPHA289596
ICD10 via Orphanet31 D10.6

Summaries for Juvenile Nasopharyngeal Angiofibroma

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MalaCards based summary: Juvenile Nasopharyngeal Angiofibroma, also known as nasopharyngeal angiofibroma, is related to nasopharyngitis and bartholin's gland benign neoplasm, and has symptoms including dyspnea and headache. An important gene associated with Juvenile Nasopharyngeal Angiofibroma is VEGFA (Vascular Endothelial Growth Factor A), and among its related pathways are Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics and Aryl Hydrocarbon Receptor. Affiliated tissues include endothelial and retina, and related mouse phenotypes are Increased cell death HMECs cells and neoplasm.

Related Diseases for Juvenile Nasopharyngeal Angiofibroma

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Diseases related to Juvenile Nasopharyngeal Angiofibroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 94)
idRelated DiseaseScoreTop Affiliating Genes
1nasopharyngitis11.1
2bartholin's gland benign neoplasm10.3ESR1, PGR
3cardiovascular organ benign neoplasm10.3ESR1, PGR
4appendix leiomyoma10.3ESR1, PGR
5bronchus adenoma10.3ESR1, PGR
6glioma10.3ESR1, PGR
7ovarian benign neoplasm10.3ESR1, PGR
8plexiform neurofibroma10.3ESR1, PGR
9adult neuronal ceroid lipofuscinosis10.3ESR1, PGR, VEGFA
10tumor of exocrine pancreas10.3ESR1, FGF2, VEGFA
11neurilemmoma of the pleura10.3FGF2, PGR, VEGFA
12benign idiopathic neonatal seizures10.3FGF2, PECAM1, VEGFA
13paranasal sinus disease10.3ESR1, PGR
14dental caries10.3ESR1, PGR, VEGFA
15nasal cavity disease10.2ESR1, PGR, VEGFA
16paraphimosis10.2ACTC1, ESR1, PGR
17pericardium leiomyoma10.2ACTC1, PCNA, PGR
18osteoblastoma10.2ESR1, PGR, TGFB3
19secondary adrenal insufficiency10.2ACTC1, FGF2
20atypical lipomatous tumor10.2ESR1, KIT, PGR
21vulva basal cell carcinoma10.2ESR1, KIT, PGR
22biliary tract neoplasm10.2ESR1, PGR, TGFB3
23middle ear adenocarcinoma10.2ESR1, KIT, PGR
24lymphomatous thyroiditis10.2PCNA, PGR
25rectal neoplasm10.2ESR1, KIT, PGR
26metagonimiasis10.2ESR1, FGF2, PGR, VEGFA
27prostatic adenoma10.2ESR1, FGF2, PGR, VEGFA
28arthus reaction10.2ESR1, KIT, PGR
29tooth erosion10.2ENG, FGF2, VEGFA
30skin angiosarcoma10.2KIT, MYC, PGR
31her2-receptor negative breast cancer10.2CYP19A1, ESR1, PGR
32osteogenesis imperfecta10.2CYP19A1, ESR1, PGR
33fallopian tube carcinosarcoma10.2ESR1, MYC, PGR, VEGFA
34acute thyroiditis10.2CYP19A1, ESR1, PGR
35perinatal jaundice due to hepatocellular damage10.2CYP19A1, ESR1, PGR
36trachea squamous cell carcinoma10.2ESR1, MYC, PGR, VEGFA
37carbon monoxide-induced parkinsonism10.2ACTC1, KIT
38endotheliitis10.2
39sebaceous adenoma10.2ACTC1, KIT, PGR
40hydrarthrosis10.2ACTC1, PGR
41bardet-biedl syndrome10.2ESR1, MYC, PGR, VEGFA
42esophagus sarcoma10.2CYP19A1, ESR1, PGR
43nevoid hypermelanosis, linear and whorled10.2ESR1, FGF2, MYC, VEGFA
44pustulosis palmaris et plantaris10.2ACTC1, KIT, PECAM1
45capillary disease10.2CYP19A1, ESR1, PGR
46breast duct papilloma10.2CYP19A1, ESR1, PGR
47isolated anterior cervical hypertrichosis10.2ACTC1, VEGFA
48fitz-hugh-curtis syndrome10.2ACTC1, KIT, PGR
49biemond syndrome10.2ACTC1, CYP19A1, PGR
50progesterone-receptor negative breast cancer10.2CYP19A1, ESR1, PGR

Graphical network of the top 20 diseases related to Juvenile Nasopharyngeal Angiofibroma:



Diseases related to juvenile nasopharyngeal angiofibroma

Symptoms & Phenotypes for Juvenile Nasopharyngeal Angiofibroma

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UMLS symptoms related to Juvenile Nasopharyngeal Angiofibroma:


dyspnea, headache

GenomeRNAi Phenotypes related to Juvenile Nasopharyngeal Angiofibroma according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00103-A-08.3BMI1, BMP6, ENG, MYC, PCNA, PGR

MGI Mouse Phenotypes related to Juvenile Nasopharyngeal Angiofibroma according to GeneCards Suite gene sharing:

41 (show all 19)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.2ESR1, FGF2, KIT, MYC, PGR, TLR3
2MP:00053888.6ENG, ESR1, KIT, PECAM1, TGFB3, TLR3
3MP:00053678.4CYP19A1, ESR1, KIT, PECAM1, TLR7, TLR9
4MP:00053817.7CYP19A1, ENG, ESR1, KIT, MYC, PECAM1
5MP:00053907.6BMP6, CYP19A1, ESR1, FGF2, KIT, MYC
6MP:00053707.6CYP11A1, CYP19A1, ESR1, KIT, MYC, PECAM1
7MP:00053797.4CYP11A1, CYP19A1, ESR1, KIT, MYC, PCNA
8MP:00028737.1ACTC1, CYP11A1, CYP19A1, ENG, ESR1, KIT
9MP:00053867.0CYP11A1, CYP19A1, ENG, ESR1, FGF2, KIT
10MP:00053897.0BMP6, CYP11A1, CYP19A1, ESR1, FGF2, KIT
11MP:00036316.9CYP11A1, CYP19A1, ENG, ESR1, FGF2, KIT
12MP:00053696.6ACTC1, CYP11A1, CYP19A1, ENG, ESR1, FGF2
13MP:00053786.5ACTC1, BMP6, CYP11A1, CYP19A1, ENG, ESR1
14MP:00053856.3ACTC1, CYP11A1, CYP19A1, ENG, ESR1, FGF2
15MP:00053876.2CYP11A1, CYP19A1, ESR1, KIT, MYC, PCNA
16MP:00053846.2ACTC1, CYP11A1, CYP19A1, ESR1, FGF2, KIT
17MP:00107686.0ACTC1, CYP11A1, ENG, ESR1, FGF2, KIT
18MP:00053765.5ACTC1, CYP11A1, CYP19A1, ENG, ESR1, FGF2
19MP:00053975.2CYP11A1, CYP19A1, ENG, ESR1, FGF2, KIT

Drugs & Therapeutics for Juvenile Nasopharyngeal Angiofibroma

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Juvenile Nasopharyngeal Angiofibroma

Genetic Tests for Juvenile Nasopharyngeal Angiofibroma

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Anatomical Context for Juvenile Nasopharyngeal Angiofibroma

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MalaCards organs/tissues related to Juvenile Nasopharyngeal Angiofibroma:

36
Endothelial, Retina

Publications for Juvenile Nasopharyngeal Angiofibroma

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Articles related to Juvenile Nasopharyngeal Angiofibroma:

(show top 50)    (show all 295)
idTitleAuthorsYear
1
Adjunctive Treatment in Juvenile Nasopharyngeal Angiofibroma: How Should We Approach Recurrence? (26907644)
2016
2
Current molecular profile of juvenile nasopharyngeal angiofibroma: First comprehensive study from India. (27577998)
2016
3
The isolation and characterization of endothelial cells from juvenile nasopharyngeal angiofibroma. (27421657)
2016
4
Endoscopic Radiofrequency Ablation-Assisted Resection of Juvenile Nasopharyngeal Angiofibroma: Comparison with Traditional Endoscopic Technique. (26932947)
2016
5
Juvenile Nasopharyngeal Angiofibroma: A Rise in Incidence. (27340627)
2016
6
Juvenile Nasopharyngeal Angiofibroma. (27164528)
2016
7
Association between vascular supply, stage and tumour size of juvenile nasopharyngeal angiofibroma. (27289235)
2016
8
Changing trends in the incidence of juvenile nasopharyngeal angiofibroma: seven decades of experience at King George's Medical University, Lucknow, India. (26864451)
2016
9
Juvenile nasopharyngeal angiofibroma. (27601836)
2016
10
Endoscopic Excision of Non-embolized Juvenile Nasopharyngeal Angiofibroma: Our Technique. (27508124)
2016
11
Juvenile Nasopharyngeal Angiofibroma Presenting with Acute Airway Obstruction. (27752379)
2016
12
In defence of transpalatal, transpalatal-circumaxillary (transpterygopalatine) and transpalatal-circumaxillary-sublabial approaches to lateral extensions of juvenile nasopharyngeal angiofibroma. (26940398)
2016
13
Current status and clinical association of beta-catenin with juvenile nasopharyngeal angiofibroma. (27572281)
2016
14
A Drastic Aftermath of Embolisation in Juvenile Nasopharyngeal Angiofibroma. (27833886)
2016
15
Time trends in recurrence of juvenile nasopharyngeal angiofibroma: Experience of the past 4 decades. (27178522)
2016
16
Human Papilloma virus in Juvenile Nasopharyngeal Angiofibroma: possible recent trend. (27157983)
2016
17
Long-term treatment outcomes of juvenile nasopharyngeal angiofibroma treated with radiotherapy. (26019389)
2015
18
Combined percutaneous and transarterial devascularisation of juvenile nasopharyngeal angiofibroma with protection of internal carotid artery: A modification of the technique. (25991005)
2015
19
Toll-like receptors 3, 7, and 9 in Juvenile nasopharyngeal angiofibroma. (25912131)
2015
20
Endoscopic graduated multiangle, multicorridor resection of juvenile nasopharyngeal angiofibroma: an individualized, tailored, multicorridor skull base approach. (26566205)
2015
21
Juvenile nasopharyngeal angiofibroma staging: An overview. (26053985)
2015
22
Clinical Characteristics of Recurrent Juvenile Nasopharyngeal Angiofibroma (JNA) After Radiation Therapy. (26693464)
2015
23
Juvenile nasopharyngeal angiofibroma: comparison between endoscopic and open operative approaches. (25974801)
2015
24
Bilateral, independent juvenile nasopharyngeal angiofibroma: case report. (26314415)
2015
25
Management of advanced intracranial intradural juvenile nasopharyngeal angiofibroma: combined single-stage rhinosurgical and neurosurgical approach. (25778926)
2015
26
Vision Loss due to Central Retinal Artery Occlusion Following Embolization in a Case of a Giant Juvenile Nasopharyngeal Angiofibroma. (26167999)
2015
27
Juvenile Nasopharyngeal Angiofibroma: Case report with review on role of imaging in diagnosis. (25684921)
2015
28
Preoperative Embolization to Improve the Surgical Management and Outcome of Juvenile Nasopharyngeal Angiofibroma (JNA) in a Single Center: 10-Year Experience. (25630469)
2015
29
Do open and endoscopic resection approaches to juvenile nasopharyngeal angiofibroma result in similar blood loss and recurrence rates? (26154365)
2015
30
Juvenile Nasopharyngeal Angiofibroma Extending into the Oral Cavity: A Rare Entity. (26266232)
2015
31
Detection of the source of hemorrhage using postmortem computerized tomographic angiography in a case of a giant juvenile nasopharyngeal angiofibroma after surgical treatment. (26213386)
2015
32
Juvenile nasopharyngeal angiofibroma presenting as a palatal swelling. (25198952)
2014
33
Bilateral juvenile nasopharyngeal angiofibroma: report of a case. (24664618)
2014
34
The presence of tumor-infiltrating IL-17-producing cells in juvenile nasopharyngeal angiofibroma tumor microenvironment is a poor prognostic factor. (25014998)
2014
35
Stridor: an unusual presentation of juvenile nasopharyngeal angiofibroma. (24711471)
2014
36
Two types of lateral extension in juvenile nasopharyngeal angiofibroma: diagnostic and therapeutic management. (24599598)
2014
37
Surgery for juvenile nasopharyngeal angiofibroma with lateral extension to the infratemporal fossa. (24685728)
2014
38
Complications in the endoscopic and endoscopic-assisted treatment of juvenile nasopharyngeal angiofibroma with intracranial extension. (24830969)
2014
39
Fully endoscopic resection of juvenile nasopharyngeal angiofibroma - own experience and clinical outcomes. (24809773)
2014
40
Hormonal receptors and vascular endothelial growth factor in juvenile nasopharyngeal angiofibroma: immunohistochemical and tissue microarray analysis. (25384380)
2014
41
Microspheres embolization of juvenile nasopharyngeal angiofibroma in an adult. (25437676)
2014
42
Prognostic value of matrix metalloproteinase 9 expression in patients with juvenile nasopharyngeal angiofibroma: tissue microarray analysis. (24969348)
2014
43
Juvenile nasopharyngeal angiofibroma resection- novel technique to improve posterior/inferior margin control. (24108672)
2013
44
Juvenile Nasopharyngeal Angiofibroma: diagnosis and surgical treatment in I and II stage with dento-alveolar involvement. (24353791)
2013
45
Surgical management of juvenile nasopharyngeal angiofibroma: Analysis of 162 cases 1995-2012. (24222212)
2013
46
Juvenile nasopharyngeal angiofibroma: a systematic review and comparison of endoscopic, endoscopic-assisted, and open resection in 1047 cases. (23483486)
2013
47
Use of coblation in resection of juvenile nasopharyngeal angiofibroma. (23837385)
2013
48
Molecular pathogenesis of juvenile nasopharyngeal angiofibroma in brazilian patients. (23802802)
2013
49
Juvenile nasopharyngeal angiofibroma: Vascular determinates for operative complications and tumor recurrence. (23929652)
2013
50
Endonasal endoscopic management of juvenile nasopharyngeal angiofibroma without angiographic embolization. (23271032)
2013

Variations for Juvenile Nasopharyngeal Angiofibroma

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Expression for genes affiliated with Juvenile Nasopharyngeal Angiofibroma

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Search GEO for disease gene expression data for Juvenile Nasopharyngeal Angiofibroma.

Pathways for genes affiliated with Juvenile Nasopharyngeal Angiofibroma

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Pathways related to Juvenile Nasopharyngeal Angiofibroma according to GeneCards Suite gene sharing:

(show all 29)
idSuper pathwaysScoreTop Affiliating Genes
19.8CYP19A1, ESR1
29.8ESR1, MYC, VEGFA
39.7FGF2, TGFB3, VEGFA
49.6PECAM1, TGFB3, TLR9
59.6ACTC1, FGF2, KIT
69.5ESR1, FGF2, MYC, VEGFA
79.5BMI1, FGF2, VEGFA
89.4BMP6, FGF2, VEGFA
9
Show member pathways
9.4ESR1, KIT, MYC, VEGFA
109.4FGF2, KIT, TGFB3, VEGFA
119.4TLR3, TLR7, TLR9
129.3CYP19A1, ESR1, MYC, VEGFA
13
Show member pathways
9.3KIT, MYC, PCNA, TGFB3
149.3ENG, ESR1, MYC, TGFB3
15
Show member pathways
9.3BMP6, MYC, TGFB3
16
Show member pathways
9.3ENG, FGF2, PECAM1, TGFB3
179.2BMI1, FGF2, MYC, VEGFA
189.2KIT, TLR7, TLR9
19
Show member pathways
9.1PCNA, TLR3, TLR7, TLR9
209.1FGF2, KIT, MYC, TGFB3, VEGFA
21
Show member pathways
9.1TGFB3, TLR3, TLR7, TLR9
22
Show member pathways
9.0ESR1, FGF2, KIT, MYC, PGR, VEGFA
238.7KIT, PECAM1, TLR3, TLR7, TLR9
248.6BMP6, CYP11A1, CYP19A1
258.6MYC, TGFB3, TLR3, TLR7, TLR9, VEGFA
268.5BMP6, ENG, FGF2, KIT, TGFB3
27
Show member pathways
8.5MYC, PCNA, TGFB3, TLR3, TLR7, TLR9
28
Show member pathways
8.2BMP6, FGF2, TGFB3, TLR3, TLR7, TLR9
29
Show member pathways
7.8BMP6, FGF2, KIT, TGFB3, TLR3, TLR7

GO Terms for genes affiliated with Juvenile Nasopharyngeal Angiofibroma

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Cellular components related to Juvenile Nasopharyngeal Angiofibroma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1early phagosomeGO:003200910.3TLR7, TLR9
2endolysosome membraneGO:003602010.1TLR3, TLR7, TLR9
3cell surfaceGO:00099869.7ENG, KIT, TGFB3, TLR3, VEGFA
4extracellular spaceGO:00056157.4ACTC1, BMP6, ENG, FGF2, KIT, PECAM1

Biological processes related to Juvenile Nasopharyngeal Angiofibroma according to GeneCards Suite gene sharing:

(show all 35)
idNameGO IDScoreTop Affiliating Genes
1cell migration involved in sprouting angiogenesisGO:000204210.8FGF2, VEGFA
2cellular response to estrogen stimulusGO:007139110.8ESR1, MYC
3positive regulation of toll-like receptor signaling pathwayGO:003412310.6TLR3, TLR9
4positive regulation of cell divisionGO:005178110.5FGF2, TGFB3, VEGFA
5response to estradiolGO:003235510.5ESR1, MYC, PCNA
6microglial cell activationGO:000177410.5TLR3, TLR7
7positive regulation of vascular smooth muscle cell differentiationGO:190506510.4ENG, KIT
8positive regulation of MAP kinase activityGO:004340610.4FGF2, KIT, VEGFA
9positive regulation of phospholipase C activityGO:001086310.4ESR1, FGF2, KIT
10ovarian follicle developmentGO:000154110.4KIT, MYC, VEGFA
11uterus developmentGO:006006510.3CYP19A1, ESR1
12positive regulation of SMAD protein import into nucleusGO:006039110.3BMP6, TGFB3
13positive regulation of fibroblast proliferationGO:004814610.2BMI1, ESR1, MYC
14positive regulation of endothelial cell proliferationGO:000193810.2BMP6, FGF2, VEGFA
15toll-like receptor 9 signaling pathwayGO:003416210.2TLR7, TLR9
16positive regulation of epithelial cell proliferationGO:005067910.1BMP6, MYC, VEGFA
17I-kappaB phosphorylationGO:000725210.1TLR3, TLR7, TLR9
18positive regulation of chemokine productionGO:003272210.1TLR3, TLR7, TLR9
19negative regulation of gene expressionGO:001062910.1ENG, ESR1, MYC, PGR
20positive regulation of inflammatory responseGO:005072910.1TLR3, TLR7, TLR9
21positive regulation of interferon-alpha biosynthetic processGO:004535610.1TLR3, TLR7, TLR9
22positive regulation of interferon-beta biosynthetic processGO:004535910.1TLR3, TLR7, TLR9
23positive regulation of interferon-gamma biosynthetic processGO:004507810.1TLR3, TLR7, TLR9
24positive regulation of interleukin-6 productionGO:003275510.1TLR3, TLR7, TLR9
25positive regulation of interleukin-8 productionGO:003275710.1TLR3, TLR7, TLR9
26positive regulation of NF-kappaB import into nucleusGO:004234610.1TLR3, TLR7, TLR9
27BMP signaling pathwayGO:00305099.9BMP6, ENG, TGFB3
28positive regulation of pathway-restricted SMAD protein phosphorylationGO:00108629.9BMP6, ENG, TGFB3
29toll-like receptor signaling pathwayGO:00022249.9TLR3, TLR7, TLR9
30wound healingGO:00420609.7FGF2, PECAM1, TGFB3
31cellular response to mechanical stimulusGO:00712609.5BMP6, ENG, TLR3, TLR7
32inflammatory responseGO:00069549.1BMP6, KIT, TLR3, TLR7, TLR9
33positive regulation of gene expressionGO:00106289.1ACTC1, ENG, KIT, MYC, TLR3, TLR9
34signal transductionGO:00071658.6ESR1, FGF2, KIT, PECAM1, PGR, TLR3
35positive regulation of transcription from RNA polymerase II promoterGO:00459448.1BMP6, ENG, ESR1, FGF2, MYC, PGR

Molecular functions related to Juvenile Nasopharyngeal Angiofibroma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1siRNA bindingGO:003519710.2TLR7, TLR9
2type I transforming growth factor beta receptor bindingGO:00347139.9ENG, TGFB3
3cytokine activityGO:00051259.8BMP6, FGF2, TGFB3, VEGFA
4type II transforming growth factor beta receptor bindingGO:00051149.8ENG, TGFB3
5growth factor activityGO:00080839.7BMP6, FGF2, TGFB3, VEGFA
6transmembrane signaling receptor activityGO:00048889.3ENG, TLR3, TLR7, TLR9

Sources for Juvenile Nasopharyngeal Angiofibroma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet