MCID: JVN033
MIFTS: 39

Juvenile Nasopharyngeal Angiofibroma

Categories: Rare diseases

Aliases & Classifications for Juvenile Nasopharyngeal Angiofibroma

MalaCards integrated aliases for Juvenile Nasopharyngeal Angiofibroma:

Name: Juvenile Nasopharyngeal Angiofibroma 56
Nasopharyngeal Angiofibroma 69
Jna 56

Characteristics:

Orphanet epidemiological data:

56
juvenile nasopharyngeal angiofibroma
Inheritance: Not applicable; Age of onset: Adolescent,Childhood;

Classifications:



External Ids:

Orphanet 56 ORPHA289596
ICD10 via Orphanet 34 D10.6

Summaries for Juvenile Nasopharyngeal Angiofibroma

MalaCards based summary : Juvenile Nasopharyngeal Angiofibroma, also known as nasopharyngeal angiofibroma, is related to histiocytoma and nasopharyngitis, and has symptoms including dyspnea and headache. An important gene associated with Juvenile Nasopharyngeal Angiofibroma is VEGFA (Vascular Endothelial Growth Factor A), and among its related pathways/superpathways are Akt Signaling and Pathways in cancer. Affiliated tissues include endothelial and retina, and related phenotypes are Increased cell death HMECs cells and hematopoietic system

Related Diseases for Juvenile Nasopharyngeal Angiofibroma

Diseases related to Juvenile Nasopharyngeal Angiofibroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 106)
id Related Disease Score Top Affiliating Genes
1 histiocytoma 29.1 ACTC1 CYP19A1 ESR1 KIT PCNA PGR
2 nasopharyngitis 11.1
3 bartholin's gland benign neoplasm 10.8 ESR1 PGR
4 central nervous system organ benign neoplasm 10.8 ESR1 PGR
5 gallbladder leiomyoma 10.8 ESR1 PGR
6 lung adenoma 10.8 ESR1 PGR
7 glaucoma, hereditary 10.8 ESR1 PGR
8 fallopian tube benign neoplasm 10.8 ESR1 PGR
9 paranasal sinus disease 10.8 ESR1 PGR
10 dartoic leiomyoma 10.8 ESR1 PGR
11 lymphocytic infiltrate of jessner 10.7 PCNA PGR
12 urinary bladder inverted papilloma 10.7 ESR1 PGR
13 spinal cancer 10.7 ESR1 PGR
14 adenosine monophosphate deaminase 1 deficiency 10.7 ESR1 PGR VEGFA
15 subglottis verrucous carcinoma 10.7 ESR1 PGR
16 gastric signet ring cell adenocarcinoma 10.7 ACTC1 ESR1
17 deafness, autosomal dominant 8/12 10.7 ESR1 PGR
18 iridogoniodysgenesis and skeletal anomalies 10.7 ACTC1 VEGFA
19 tumor of exocrine pancreas 10.7 ESR1 FGF2 VEGFA
20 posterior foramen magnum meningioma 10.7 FGF2 PGR VEGFA
21 scn8a encephalopathy 10.7 ACTC1 FGF2
22 trachea carcinoma in situ 10.6 ESR1 PGR VEGFA
23 waterhouse-friderichsen syndrome 10.6 ESR1 PECAM1 VEGFA
24 segmental odontomaxillary dysplasia 10.6 FGF2 PECAM1 VEGFA
25 intestinal perforation 10.6 ESR1 PGR
26 cutaneous leiomyosarcoma 10.6 ACTC1 PGR
27 retinal detachment 10.6 ACTC1 ESR1 PGR
28 thoracic benign neoplasm 10.6 ESR1 PGR TGFB3
29 gastric tubular adenocarcinoma 10.6 ESR1 PGR
30 gastrointestinal system benign neoplasm 10.6 ESR1 PGR TGFB3
31 leiomyoma cutis 10.6 ACTC1 PCNA PGR
32 marfanoid habitus-inguinal hernia-advanced bone age syndrome 10.6 ACTC1 KIT
33 superficial basal cell carcinoma 10.5 ESR1 KIT PGR
34 kidney clear cell sarcoma 10.5 ESR1 KIT PGR
35 rectal neoplasm 10.5 ESR1 KIT PGR
36 gangliosidosis gm1 10.5 KIT MYC
37 hypersensitivity reaction type iii disease 10.5 ESR1 KIT PGR
38 tooth erosion 10.5 ENG FGF2 VEGFA
39 endometriosis of uterus 10.5 ESR1 FGF2 PGR VEGFA
40 retinal disease 10.5 ESR1 KIT PGR
41 gestational choriocarcinoma 10.5 FGF2 KIT VEGFA
42 her2-receptor positive breast cancer 10.5 CYP19A1 ESR1 PGR
43 osteogenesis imperfecta 10.5 CYP19A1 ESR1 PGR
44 acute thyroiditis 10.5 CYP19A1 ESR1 PGR
45 fallopian tube carcinosarcoma 10.4 ESR1 MYC PGR VEGFA
46 diffuse lipomatosis 10.4 PGR VEGFA
47 perinatal jaundice due to hepatocellular damage 10.4 CYP19A1 ESR1 PGR
48 salivary gland adenoid cystic carcinoma 10.4 ENG VEGFA
49 liver angiosarcoma 10.4 ACTC1 KIT PGR
50 sebaceous adenoma 10.4 ACTC1 KIT PGR

Graphical network of the top 20 diseases related to Juvenile Nasopharyngeal Angiofibroma:



Diseases related to Juvenile Nasopharyngeal Angiofibroma

Symptoms & Phenotypes for Juvenile Nasopharyngeal Angiofibroma

UMLS symptoms related to Juvenile Nasopharyngeal Angiofibroma:


dyspnea, headache

GenomeRNAi Phenotypes related to Juvenile Nasopharyngeal Angiofibroma according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death HMECs cells GR00103-A-0 9.17 BMI1 BMP6 ENG MYC PCNA PGR

MGI Mouse Phenotypes related to Juvenile Nasopharyngeal Angiofibroma:

44 (show all 19)
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.4 ESR1 CYP19A1 CYP11A1 ENG FGF2 MYC
2 cardiovascular system MP:0005385 10.39 ENG ESR1 CYP19A1 ACTC1 CYP11A1 FGF2
3 homeostasis/metabolism MP:0005376 10.39 CYP11A1 ENG ESR1 CYP19A1 ACTC1 FGF2
4 cellular MP:0005384 10.38 CYP11A1 CYP19A1 ACTC1 FGF2 MYC ESR1
5 behavior/neurological MP:0005386 10.32 ENG CYP11A1 CYP19A1 FGF2 ESR1 KIT
6 immune system MP:0005387 10.31 CYP11A1 ESR1 CYP19A1 MYC KIT PECAM1
7 mortality/aging MP:0010768 10.3 ENG CYP11A1 ACTC1 FGF2 MYC ESR1
8 growth/size/body region MP:0005378 10.28 ENG CYP11A1 ACTC1 BMP6 CYP19A1 ESR1
9 digestive/alimentary MP:0005381 10.21 ENG CYP19A1 MYC ESR1 KIT PECAM1
10 muscle MP:0005369 10.21 ESR1 CYP19A1 ACTC1 CYP11A1 ENG FGF2
11 endocrine/exocrine gland MP:0005379 10.2 CYP11A1 CYP19A1 ESR1 KIT MYC PGR
12 nervous system MP:0003631 10.07 ENG CYP11A1 CYP19A1 KIT FGF2 ESR1
13 liver/biliary system MP:0005370 10.02 CYP11A1 CYP19A1 ESR1 KIT PECAM1 MYC
14 normal MP:0002873 10.02 ENG CYP11A1 CYP19A1 ACTC1 MYC ESR1
15 neoplasm MP:0002006 9.95 FGF2 MYC ESR1 KIT TLR3 PGR
16 reproductive system MP:0005389 9.9 CYP11A1 CYP19A1 BMP6 FGF2 MYC ESR1
17 renal/urinary system MP:0005367 9.8 CYP19A1 ESR1 KIT PECAM1 TLR9 VEGFA
18 respiratory system MP:0005388 9.5 ENG KIT ESR1 TGFB3 PECAM1 TLR3
19 skeleton MP:0005390 9.32 CYP19A1 BMP6 FGF2 MYC ESR1 KIT

Drugs & Therapeutics for Juvenile Nasopharyngeal Angiofibroma

Search Clinical Trials , NIH Clinical Center for Juvenile Nasopharyngeal Angiofibroma

Genetic Tests for Juvenile Nasopharyngeal Angiofibroma

Anatomical Context for Juvenile Nasopharyngeal Angiofibroma

MalaCards organs/tissues related to Juvenile Nasopharyngeal Angiofibroma:

39
Endothelial, Retina

Publications for Juvenile Nasopharyngeal Angiofibroma

Articles related to Juvenile Nasopharyngeal Angiofibroma:

(show top 50) (show all 305)
id Title Authors Year
1
Reassessing the Anatomic Origin of the Juvenile Nasopharyngeal Angiofibroma. ( 28632604 )
2017
2
Trigeminocardiac reflex during endoscopic juvenile nasopharyngeal angiofibroma surgery: an appraisal. ( 28324181 )
2017
3
Juvenile Nasopharyngeal Angiofibroma: A Case Report. ( 28571176 )
2017
4
Imaging in Juvenile Nasopharyngeal Angiofibroma: Clinical Significance of Ramharan and Chopstick Sign. ( 28239585 )
2017
5
Massive juvenile nasopharyngeal angiofibroma: ode to the open surgical approach. ( 28765177 )
2017
6
Perioperative airway management of a 16-year-old boy with progressive airway obstruction due to juvenile nasopharyngeal angiofibroma. ( 28781841 )
2017
7
Complications of Midface Swing for Management of Juvenile Nasopharyngeal Angiofibroma. ( 28286392 )
2017
8
Inhibition of fibroblast growth factor receptor with AZD4547 mitigates juvenile nasopharyngeal angiofibroma. ( 28707818 )
2017
9
Variable expression of molecular markers in juvenile nasopharyngeal angiofibroma. ( 28683841 )
2017
10
The isolation and characterization of endothelial cells from juvenile nasopharyngeal angiofibroma. ( 27421657 )
2016
11
Endoscopic Excision of Non-embolized Juvenile Nasopharyngeal Angiofibroma: Our Technique. ( 27508124 )
2016
12
Juvenile Nasopharyngeal Angiofibroma. ( 27164528 )
2016
13
Changing trends in the incidence of juvenile nasopharyngeal angiofibroma: seven decades of experience at King George's Medical University, Lucknow, India. ( 26864451 )
2016
14
Endoscopic Radiofrequency Ablation-Assisted Resection of Juvenile Nasopharyngeal Angiofibroma: Comparison with Traditional Endoscopic Technique. ( 26932947 )
2016
15
A Drastic Aftermath of Embolisation in Juvenile Nasopharyngeal Angiofibroma. ( 27833886 )
2016
16
In defence of transpalatal, transpalatal-circumaxillary (transpterygopalatine) and transpalatal-circumaxillary-sublabial approaches to lateral extensions of juvenile nasopharyngeal angiofibroma. ( 26940398 )
2016
17
Juvenile Nasopharyngeal Angiofibroma: A Rise in Incidence. ( 27340627 )
2016
18
Human Papilloma virus in Juvenile Nasopharyngeal Angiofibroma: possible recent trend. ( 27157983 )
2016
19
Adjunctive Treatment in Juvenile Nasopharyngeal Angiofibroma: How Should We Approach Recurrence? ( 26907644 )
2016
20
Multiport Combined Endoscopic Approach to Nonembolized Juvenile Nasopharyngeal Angiofibroma with Parapharyngeal Extension: An Emerging Concept. ( 28101106 )
2016
21
Current status and clinical association of beta-catenin with juvenile nasopharyngeal angiofibroma. ( 27572281 )
2016
22
Association between vascular supply, stage and tumour size of juvenile nasopharyngeal angiofibroma. ( 27289235 )
2016
23
Juvenile Nasopharyngeal Angiofibroma Presenting with Acute Airway Obstruction. ( 27752379 )
2016
24
Juvenile nasopharyngeal angiofibroma. ( 27601836 )
2016
25
Current molecular profile of juvenile nasopharyngeal angiofibroma: First comprehensive study from India. ( 27577998 )
2016
26
Time trends in recurrence of juvenile nasopharyngeal angiofibroma: Experience of the past 4 decades. ( 27178522 )
2016
27
Long-term treatment outcomes of juvenile nasopharyngeal angiofibroma treated with radiotherapy. ( 26019389 )
2015
28
Endoscopic graduated multiangle, multicorridor resection of juvenile nasopharyngeal angiofibroma: an individualized, tailored, multicorridor skull base approach. ( 26566205 )
2015
29
Toll-like receptors 3, 7, and 9 in Juvenile nasopharyngeal angiofibroma. ( 25912131 )
2015
30
Bilateral, independent juvenile nasopharyngeal angiofibroma: case report. ( 26314415 )
2015
31
Do open and endoscopic resection approaches to juvenile nasopharyngeal angiofibroma result in similar blood loss and recurrence rates? ( 26154365 )
2015
32
Detection of the source of hemorrhage using postmortem computerized tomographic angiography in a case of a giant juvenile nasopharyngeal angiofibroma after surgical treatment. ( 26213386 )
2015
33
Juvenile Nasopharyngeal Angiofibroma Extending into the Oral Cavity: A Rare Entity. ( 26266232 )
2015
34
Clinical Characteristics of Recurrent Juvenile Nasopharyngeal Angiofibroma (JNA) After Radiation Therapy. ( 26693464 )
2015
35
Vision Loss due to Central Retinal Artery Occlusion Following Embolization in a Case of a Giant Juvenile Nasopharyngeal Angiofibroma. ( 26167999 )
2015
36
Management of advanced intracranial intradural juvenile nasopharyngeal angiofibroma: combined single-stage rhinosurgical and neurosurgical approach. ( 25778926 )
2015
37
Preoperative Embolization to Improve the Surgical Management and Outcome of Juvenile Nasopharyngeal Angiofibroma (JNA) in a Single Center: 10-Year Experience. ( 25630469 )
2015
38
Juvenile nasopharyngeal angiofibroma staging: An overview. ( 26053985 )
2015
39
Juvenile nasopharyngeal angiofibroma: comparison between endoscopic and open operative approaches. ( 25974801 )
2015
40
Juvenile Nasopharyngeal Angiofibroma: Case report with review on role of imaging in diagnosis. ( 25684921 )
2015
41
Combined percutaneous and transarterial devascularisation of juvenile nasopharyngeal angiofibroma with protection of internal carotid artery: A modification of the technique. ( 25991005 )
2015
42
Surgery for juvenile nasopharyngeal angiofibroma with lateral extension to the infratemporal fossa. ( 24685728 )
2014
43
Stridor: an unusual presentation of juvenile nasopharyngeal angiofibroma. ( 24711471 )
2014
44
Fully endoscopic resection of juvenile nasopharyngeal angiofibroma - own experience and clinical outcomes. ( 24809773 )
2014
45
Bilateral juvenile nasopharyngeal angiofibroma: report of a case. ( 24664618 )
2014
46
The presence of tumor-infiltrating IL-17-producing cells in juvenile nasopharyngeal angiofibroma tumor microenvironment is a poor prognostic factor. ( 25014998 )
2014
47
Prognostic value of matrix metalloproteinase 9 expression in patients with juvenile nasopharyngeal angiofibroma: tissue microarray analysis. ( 24969348 )
2014
48
Microspheres embolization of juvenile nasopharyngeal angiofibroma in an adult. ( 25437676 )
2014
49
Hormonal receptors and vascular endothelial growth factor in juvenile nasopharyngeal angiofibroma: immunohistochemical and tissue microarray analysis. ( 25384380 )
2014
50
Complications in the endoscopic and endoscopic-assisted treatment of juvenile nasopharyngeal angiofibroma with intracranial extension. ( 24830969 )
2014

Variations for Juvenile Nasopharyngeal Angiofibroma

Expression for Juvenile Nasopharyngeal Angiofibroma

Search GEO for disease gene expression data for Juvenile Nasopharyngeal Angiofibroma.

Pathways for Juvenile Nasopharyngeal Angiofibroma

Pathways related to Juvenile Nasopharyngeal Angiofibroma according to GeneCards Suite gene sharing:

(show all 28)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.32 BMP6 FGF2 KIT TGFB3 TLR3 TLR7
2 12.59 FGF2 KIT MYC TGFB3 VEGFA
3 12.42 KIT PECAM1 TLR3 TLR7 TLR9
4
Show member pathways
12.42 BMP6 FGF2 TGFB3 TLR3 TLR7 TLR9
5 12.21 ESR1 FGF2 MYC VEGFA
6
Show member pathways
12.21 ESR1 FGF2 KIT MYC PCNA PGR
7 12.04 CYP19A1 ESR1 MYC VEGFA
8 11.94 BMI1 FGF2 MYC VEGFA
9 11.93 PCNA TLR3 TLR7 TLR9
10
Show member pathways
11.84 TLR3 TLR7 TLR9
11 11.76 ENG ESR1 MYC TGFB3
12 11.73 TLR3 TLR7 TLR9
13 11.72 BMP6 MYC TGFB3
14
Show member pathways
11.71 TGFB3 TLR3 TLR7 TLR9
15 11.7 BMI1 FGF2 VEGFA
16
Show member pathways
11.7 ESR1 KIT MYC VEGFA
17 11.67 KIT TLR7 TLR9
18 11.61 ENG FGF2 PECAM1 TGFB3
19 11.59 BMP6 FGF2 VEGFA
20 11.48 ACTC1 FGF2 KIT
21 11.45 BMP6 CYP11A1 CYP19A1
22 11.43 PECAM1 TGFB3 TLR9
23 11.42 ESR1 MYC VEGFA
24 11.34 BMP6 ENG FGF2 KIT TGFB3
25 11.32 MYC TGFB3 TLR3 TLR7 TLR9 VEGFA
26 11.14 FGF2 KIT TGFB3 VEGFA
27 11.07 FGF2 TGFB3 VEGFA
28 10.14 CYP19A1 ESR1

GO Terms for Juvenile Nasopharyngeal Angiofibroma

Cellular components related to Juvenile Nasopharyngeal Angiofibroma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.65 ENG KIT TGFB3 TLR3 VEGFA
2 extracellular space GO:0005615 9.61 ACTC1 BMP6 ENG FGF2 KIT PECAM1
3 early phagosome GO:0032009 9.16 TLR7 TLR9
4 endolysosome membrane GO:0036020 8.8 TLR3 TLR7 TLR9

Biological processes related to Juvenile Nasopharyngeal Angiofibroma according to GeneCards Suite gene sharing:

(show all 33)
id Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.99 BMP6 KIT TLR3 TLR7 TLR9
2 wound healing GO:0042060 9.81 FGF2 PECAM1 TGFB3
3 BMP signaling pathway GO:0030509 9.81 BMP6 ENG TGFB3
4 positive regulation of endothelial cell proliferation GO:0001938 9.8 BMP6 FGF2 VEGFA
5 positive regulation of inflammatory response GO:0050729 9.79 TLR3 TLR7 TLR9
6 positive regulation of epithelial cell proliferation GO:0050679 9.78 BMP6 MYC VEGFA
7 positive regulation of MAP kinase activity GO:0043406 9.77 FGF2 KIT VEGFA
8 positive regulation of fibroblast proliferation GO:0048146 9.76 BMI1 ESR1 MYC
9 cellular response to mechanical stimulus GO:0071260 9.76 BMP6 ENG TLR3 TLR7
10 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.74 BMP6 ENG TGFB3
11 positive regulation of interleukin-6 production GO:0032755 9.73 TLR3 TLR7 TLR9
12 positive regulation of cell division GO:0051781 9.72 FGF2 TGFB3 VEGFA
13 toll-like receptor signaling pathway GO:0002224 9.71 TLR3 TLR7 TLR9
14 positive regulation of gene expression GO:0010628 9.7 ACTC1 ENG KIT MYC TLR3 TLR9
15 positive regulation of interleukin-8 production GO:0032757 9.67 TLR3 TLR7 TLR9
16 uterus development GO:0060065 9.66 CYP19A1 ESR1
17 toll-like receptor 9 signaling pathway GO:0034162 9.65 TLR7 TLR9
18 microglial cell activation GO:0001774 9.65 TLR3 TLR7
19 positive regulation of NF-kappaB import into nucleus GO:0042346 9.65 TLR3 TLR7 TLR9
20 cell migration involved in sprouting angiogenesis GO:0002042 9.64 FGF2 VEGFA
21 positive regulation of SMAD protein import into nucleus GO:0060391 9.63 BMP6 TGFB3
22 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.61 KIT VEGFA
23 positive regulation of chemokine production GO:0032722 9.61 TLR3 TLR7 TLR9
24 positive regulation of vascular smooth muscle cell differentiation GO:1905065 9.58 ENG KIT
25 positive regulation of interferon-gamma biosynthetic process GO:0045078 9.58 TLR3 TLR7 TLR9
26 I-kappaB phosphorylation GO:0007252 9.54 TLR3 TLR7 TLR9
27 positive regulation of toll-like receptor signaling pathway GO:0034123 9.52 TLR3 TLR9
28 mammary gland development GO:0030879 9.51 CYP19A1 TGFB3
29 positive regulation of phospholipase C activity GO:0010863 9.5 ESR1 FGF2 KIT
30 positive regulation of interferon-beta biosynthetic process GO:0045359 9.43 TLR3 TLR7 TLR9
31 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.32 BMP6 ENG ESR1 FGF2 MYC PGR
32 positive regulation of interferon-alpha biosynthetic process GO:0045356 9.13 TLR3 TLR7 TLR9
33 signal transduction GO:0007165 10.25 ESR1 FGF2 KIT PECAM1 PGR TLR3

Molecular functions related to Juvenile Nasopharyngeal Angiofibroma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transmembrane signaling receptor activity GO:0004888 9.67 ENG TLR3 TLR7 TLR9
2 cytokine activity GO:0005125 9.46 BMP6 FGF2 TGFB3 VEGFA
3 type I transforming growth factor beta receptor binding GO:0034713 9.32 ENG TGFB3
4 siRNA binding GO:0035197 9.26 TLR7 TLR9
5 type II transforming growth factor beta receptor binding GO:0005114 8.96 ENG TGFB3
6 growth factor activity GO:0008083 8.92 BMP6 FGF2 TGFB3 VEGFA

Sources for Juvenile Nasopharyngeal Angiofibroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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