MCID: JVN033
MIFTS: 39

Juvenile Nasopharyngeal Angiofibroma malady

Category: Rare diseases

Aliases & Classifications for Juvenile Nasopharyngeal Angiofibroma

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Sources:
31ICD10 via Orphanet, 54Orphanet, 68UMLS
See all MalaCards sources

Aliases & Descriptions for Juvenile Nasopharyngeal Angiofibroma:

Name: Juvenile Nasopharyngeal Angiofibroma 54
Nasopharyngeal Angiofibroma 68
 
Jna 54

Characteristics:

Orphanet epidemiological data:

54
juvenile nasopharyngeal angiofibroma:
Inheritance: Not applicable; Age of onset: Adolescent,Childhood

Classifications:



External Ids:

Orphanet54 ORPHA289596
ICD10 via Orphanet31 D10.6

Summaries for Juvenile Nasopharyngeal Angiofibroma

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MalaCards based summary: Juvenile Nasopharyngeal Angiofibroma, also known as nasopharyngeal angiofibroma, is related to nasopharyngitis and vulvar angiokeratoma, and has symptoms including dyspnea and headache. An important gene associated with Juvenile Nasopharyngeal Angiofibroma is VEGFA (Vascular Endothelial Growth Factor A), and among its related pathways are Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics and Vemurafenib Pathway, Pharmacodynamics. Affiliated tissues include endothelial and retina, and related mouse phenotypes are Increased cell death HMECs cells and limbs/digits/tail.

Related Diseases for Juvenile Nasopharyngeal Angiofibroma

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Diseases related to Juvenile Nasopharyngeal Angiofibroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 102)
idRelated DiseaseScoreTop Affiliating Genes
1nasopharyngitis11.1
2vulvar angiokeratoma10.7ESR1, PGR
3central nervous system organ benign neoplasm10.7ESR1, PGR
4fallopian tube benign neoplasm10.7ESR1, PGR
5appendix leiomyoma10.7ESR1, PGR
6mixed cell adenoma10.7ESR1, PGR
7gelatinous ascites10.7ESR1, PGR
8deafness, autosomal dominant 8/1210.6ESR1, PGR
9perinatal intestinal perforation10.6ESR1, PGR
10lymphocytic vasculitis10.6PCNA, PGR
11trigeminal nerve disease10.6ESR1, PGR
12glottis verrucous carcinoma10.6ESR1, PGR
13adenosine monophosphate deaminase 1 deficiency10.6ESR1, PGR, VEGFA
14colorectal adenoma10.6FGF2, VEGFA
15chiari malformation type 310.6ACTC1, FGF2
16iridogoniodysgenesis and skeletal anomalies10.6ACTC1, VEGFA
17gastric small cell carcinoma10.6FGF2, PGR, VEGFA
18dental caries10.5ESR1, PGR, VEGFA
19ovarian wilms' cancer10.5ESR1, PGR, VEGFA
20bladder colonic type adenocarcinoma10.5ESR1, PGR
21developmental coordination disorder10.5ESR1, PECAM1, VEGFA
22lobular neoplasia10.5ESR1, PGR, VEGFA
23adenocarcinoma in situ10.5ESR1, PGR
24thoracic benign neoplasm10.5ESR1, PGR, TGFB3
25fallopian tube germ cell cancer10.5ACTC1, ESR1, PGR
26gastrointestinal system benign neoplasm10.5ESR1, PGR, TGFB3
27simple partial epilepsy10.5ACTC1, PCNA, PGR
28small intestinal sarcoma10.5ACTC1, ESR1, PGR
29bartholin's gland adenoid cystic carcinoma10.4ESR1, KIT, PGR
30asthma susceptibility 510.4ESR1, PGR
31infiltrative basal cell carcinoma10.4ESR1, KIT, PGR
32xq12-q13.3 duplication syndrome10.4ACTC1, KIT
33vibratory urticaria10.4ESR1, KIT, PGR
34vhl-related pheochromocytoma10.4ENG, ESR1
35prostate adenoid cystic carcinoma10.4KIT, PGR, VEGFA
36nerve fibre bundle defect10.4ESR1, KIT, PGR
37pancreatic serous cystic neoplasm10.4PGR, VEGFA
38epithelioid type angiomyolipoma10.4ESR1, KIT, PGR
39lung carcinoma in situ10.4ESR1, FGF2, PGR, VEGFA
40vulvar leiomyoma10.4ESR1, KIT, PGR
41enamel erosion10.4ENG, FGF2, VEGFA
42nodular degeneration of cornea10.4ESR1, FGF2, PGR, VEGFA
43spinal cord astrocytoma10.4ENG, VEGFA
44gallbladder angiosarcoma10.4KIT, MYC, PGR
45placental choriocarcinoma10.4FGF2, KIT, VEGFA
46gangliosidosis gm210.4KIT, MYC
47fallopian tube adenosarcoma10.4ESR1, KIT, PGR
48her2-receptor positive breast cancer10.4CYP19A1, ESR1, PGR
49retroperitoneum carcinoma10.4CYP19A1, ESR1, PGR
50leiomyosarcoma10.4ESR1, MYC, PGR, VEGFA

Graphical network of the top 20 diseases related to Juvenile Nasopharyngeal Angiofibroma:



Diseases related to juvenile nasopharyngeal angiofibroma

Symptoms & Phenotypes for Juvenile Nasopharyngeal Angiofibroma

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UMLS symptoms related to Juvenile Nasopharyngeal Angiofibroma:


dyspnea, headache

GenomeRNAi Phenotypes related to Juvenile Nasopharyngeal Angiofibroma according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00103-A-08.4BMI1, BMP6, ENG, MYC, PCNA, PGR

MGI Mouse Phenotypes related to Juvenile Nasopharyngeal Angiofibroma according to GeneCards Suite gene sharing:

41 (show all 19)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053719.2ESR1, KIT, MYC, PGR, TGFB3, VEGFA
2MP:00020069.1ESR1, FGF2, KIT, MYC, PGR, TLR3
3MP:00053888.8ENG, ESR1, KIT, PECAM1, TGFB3, TLR3
4MP:00053678.1CYP19A1, ESR1, KIT, PECAM1, TLR7, TLR9
5MP:00053797.8CYP11A1, CYP19A1, ESR1, KIT, MYC, PCNA
6MP:00053907.7BMP6, CYP19A1, ESR1, FGF2, KIT, MYC
7MP:00053817.3CYP19A1, ENG, ESR1, KIT, MYC, PECAM1
8MP:00028737.1ACTC1, CYP11A1, CYP19A1, ENG, ESR1, KIT
9MP:00036317.0CYP11A1, CYP19A1, ENG, ESR1, FGF2, KIT
10MP:00053896.9BMP6, CYP11A1, CYP19A1, ESR1, FGF2, KIT
11MP:00053866.9CYP11A1, CYP19A1, ENG, ESR1, FGF2, KIT
12MP:00053856.8ACTC1, CYP19A1, ENG, ESR1, FGF2, KIT
13MP:00053696.8ACTC1, CYP11A1, CYP19A1, ENG, ESR1, FGF2
14MP:00053876.5CYP11A1, CYP19A1, ESR1, KIT, MYC, PCNA
15MP:00053786.3ACTC1, BMP6, CYP11A1, CYP19A1, ENG, ESR1
16MP:00053846.2ACTC1, CYP11A1, CYP19A1, ESR1, FGF2, KIT
17MP:00107685.9ACTC1, CYP11A1, ENG, ESR1, FGF2, KIT
18MP:00053975.8CYP11A1, CYP19A1, ENG, ESR1, FGF2, KIT
19MP:00053765.3ACTC1, CYP11A1, CYP19A1, ENG, ESR1, FGF2

Drugs & Therapeutics for Juvenile Nasopharyngeal Angiofibroma

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Juvenile Nasopharyngeal Angiofibroma

Genetic Tests for Juvenile Nasopharyngeal Angiofibroma

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Anatomical Context for Juvenile Nasopharyngeal Angiofibroma

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MalaCards organs/tissues related to Juvenile Nasopharyngeal Angiofibroma:

36
Endothelial, Retina

Publications for Juvenile Nasopharyngeal Angiofibroma

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Articles related to Juvenile Nasopharyngeal Angiofibroma:

(show top 50)    (show all 295)
idTitleAuthorsYear
1
A Drastic Aftermath of Embolisation in Juvenile Nasopharyngeal Angiofibroma. (27833886)
2016
2
Juvenile nasopharyngeal angiofibroma. (27601836)
2016
3
In defence of transpalatal, transpalatal-circumaxillary (transpterygopalatine) and transpalatal-circumaxillary-sublabial approaches to lateral extensions of juvenile nasopharyngeal angiofibroma. (26940398)
2016
4
Adjunctive Treatment in Juvenile Nasopharyngeal Angiofibroma: How Should We Approach Recurrence? (26907644)
2016
5
Juvenile Nasopharyngeal Angiofibroma. (27164528)
2016
6
Juvenile Nasopharyngeal Angiofibroma Presenting with Acute Airway Obstruction. (27752379)
2016
7
Current molecular profile of juvenile nasopharyngeal angiofibroma: First comprehensive study from India. (27577998)
2016
8
Time trends in recurrence of juvenile nasopharyngeal angiofibroma: Experience of the past 4 decades. (27178522)
2016
9
Changing trends in the incidence of juvenile nasopharyngeal angiofibroma: seven decades of experience at King George's Medical University, Lucknow, India. (26864451)
2016
10
Association between vascular supply, stage and tumour size of juvenile nasopharyngeal angiofibroma. (27289235)
2016
11
The isolation and characterization of endothelial cells from juvenile nasopharyngeal angiofibroma. (27421657)
2016
12
Endoscopic Excision of Non-embolized Juvenile Nasopharyngeal Angiofibroma: Our Technique. (27508124)
2016
13
Endoscopic Radiofrequency Ablation-Assisted Resection of Juvenile Nasopharyngeal Angiofibroma: Comparison with Traditional Endoscopic Technique. (26932947)
2016
14
Juvenile Nasopharyngeal Angiofibroma: A Rise in Incidence. (27340627)
2016
15
Current status and clinical association of beta-catenin with juvenile nasopharyngeal angiofibroma. (27572281)
2016
16
Human Papilloma virus in Juvenile Nasopharyngeal Angiofibroma: possible recent trend. (27157983)
2016
17
Bilateral, independent juvenile nasopharyngeal angiofibroma: case report. (26314415)
2015
18
Preoperative Embolization to Improve the Surgical Management and Outcome of Juvenile Nasopharyngeal Angiofibroma (JNA) in a Single Center: 10-Year Experience. (25630469)
2015
19
Toll-like receptors 3, 7, and 9 in Juvenile nasopharyngeal angiofibroma. (25912131)
2015
20
Juvenile Nasopharyngeal Angiofibroma: Case report with review on role of imaging in diagnosis. (25684921)
2015
21
Juvenile Nasopharyngeal Angiofibroma Extending into the Oral Cavity: A Rare Entity. (26266232)
2015
22
Juvenile nasopharyngeal angiofibroma: comparison between endoscopic and open operative approaches. (25974801)
2015
23
Clinical Characteristics of Recurrent Juvenile Nasopharyngeal Angiofibroma (JNA) After Radiation Therapy. (26693464)
2015
24
Long-term treatment outcomes of juvenile nasopharyngeal angiofibroma treated with radiotherapy. (26019389)
2015
25
Endoscopic graduated multiangle, multicorridor resection of juvenile nasopharyngeal angiofibroma: an individualized, tailored, multicorridor skull base approach. (26566205)
2015
26
Combined percutaneous and transarterial devascularisation of juvenile nasopharyngeal angiofibroma with protection of internal carotid artery: A modification of the technique. (25991005)
2015
27
Juvenile nasopharyngeal angiofibroma staging: An overview. (26053985)
2015
28
Vision Loss due to Central Retinal Artery Occlusion Following Embolization in a Case of a Giant Juvenile Nasopharyngeal Angiofibroma. (26167999)
2015
29
Detection of the source of hemorrhage using postmortem computerized tomographic angiography in a case of a giant juvenile nasopharyngeal angiofibroma after surgical treatment. (26213386)
2015
30
Do open and endoscopic resection approaches to juvenile nasopharyngeal angiofibroma result in similar blood loss and recurrence rates? (26154365)
2015
31
Management of advanced intracranial intradural juvenile nasopharyngeal angiofibroma: combined single-stage rhinosurgical and neurosurgical approach. (25778926)
2015
32
Stridor: an unusual presentation of juvenile nasopharyngeal angiofibroma. (24711471)
2014
33
Two types of lateral extension in juvenile nasopharyngeal angiofibroma: diagnostic and therapeutic management. (24599598)
2014
34
Hormonal receptors and vascular endothelial growth factor in juvenile nasopharyngeal angiofibroma: immunohistochemical and tissue microarray analysis. (25384380)
2014
35
Bilateral juvenile nasopharyngeal angiofibroma: report of a case. (24664618)
2014
36
Microspheres embolization of juvenile nasopharyngeal angiofibroma in an adult. (25437676)
2014
37
The presence of tumor-infiltrating IL-17-producing cells in juvenile nasopharyngeal angiofibroma tumor microenvironment is a poor prognostic factor. (25014998)
2014
38
Prognostic value of matrix metalloproteinase 9 expression in patients with juvenile nasopharyngeal angiofibroma: tissue microarray analysis. (24969348)
2014
39
Juvenile nasopharyngeal angiofibroma presenting as a palatal swelling. (25198952)
2014
40
Complications in the endoscopic and endoscopic-assisted treatment of juvenile nasopharyngeal angiofibroma with intracranial extension. (24830969)
2014
41
Surgery for juvenile nasopharyngeal angiofibroma with lateral extension to the infratemporal fossa. (24685728)
2014
42
Fully endoscopic resection of juvenile nasopharyngeal angiofibroma - own experience and clinical outcomes. (24809773)
2014
43
Endonasal endoscopic management of juvenile nasopharyngeal angiofibroma without angiographic embolization. (23271032)
2013
44
Juvenile nasopharyngeal angiofibroma: Vascular determinates for operative complications and tumor recurrence. (23929652)
2013
45
Endoglin (CD105) expression on microvessel endothelial cells in juvenile nasopharyngeal angiofibroma: tissue microarray analysis and association with prognostic significance. (23471755)
2013
46
Invasive growth patterns of juvenile nasopharyngeal angiofibroma: radiological imaging and clinical implications. (24132768)
2013
47
Juvenile nasopharyngeal angiofibroma: a systematic review and comparison of endoscopic, endoscopic-assisted, and open resection in 1047 cases. (23483486)
2013
48
A systematic review of surgical outcomes for advanced juvenile nasopharyngeal angiofibroma with intracranial involvement. (23553370)
2013
49
Juvenile nasopharyngeal angiofibroma: Timisoara ENT Department's experience. (23732022)
2013
50
Imaging in the diagnosis of juvenile nasopharyngeal angiofibroma. (23878770)
2013

Variations for Juvenile Nasopharyngeal Angiofibroma

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Expression for genes affiliated with Juvenile Nasopharyngeal Angiofibroma

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Search GEO for disease gene expression data for Juvenile Nasopharyngeal Angiofibroma.

Pathways for genes affiliated with Juvenile Nasopharyngeal Angiofibroma

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Pathways related to Juvenile Nasopharyngeal Angiofibroma according to GeneCards Suite gene sharing:

(show all 29)
idSuper pathwaysScoreTop Affiliating Genes
19.8CYP19A1, ESR1
29.8FGF2, MYC, VEGFA
39.7FGF2, TGFB3, VEGFA
49.6PECAM1, TGFB3, TLR9
59.6ACTC1, FGF2, KIT
69.5ESR1, FGF2, MYC, VEGFA
79.5BMI1, FGF2, VEGFA
89.4BMP6, FGF2, VEGFA
9
Show member pathways
9.4TLR3, TLR7, TLR9
109.4TLR3, TLR7, TLR9
119.3CYP19A1, ESR1, MYC, VEGFA
129.3ESR1, FGF2, MYC, PCNA, VEGFA
13
Show member pathways
9.3KIT, MYC, PCNA, TGFB3
149.3ENG, ESR1, MYC, TGFB3
159.3ENG, ESR1, MYC, TGFB3
16
Show member pathways
9.3ENG, FGF2, PECAM1, TGFB3
179.2BMI1, FGF2, MYC, VEGFA
189.2KIT, TLR7, TLR9
19
Show member pathways
9.1PCNA, TLR3, TLR7, TLR9
209.1FGF2, KIT, MYC, TGFB3, VEGFA
21
Show member pathways
9.1TGFB3, TLR3, TLR7, TLR9
228.6BMI1, BMP6, ENG, TGFB3
238.6BMP6, CYP11A1, CYP19A1
248.6MYC, TGFB3, TLR3, TLR7, TLR9, VEGFA
258.5BMP6, ENG, FGF2, KIT, TGFB3
26
Show member pathways
8.5MYC, PCNA, TGFB3, TLR3, TLR7, TLR9
27
Show member pathways
8.2BMP6, FGF2, TGFB3, TLR3, TLR7, TLR9
288.2BMI1, KIT, PECAM1, TLR3, TLR7, TLR9
29
Show member pathways
7.8BMP6, FGF2, KIT, TGFB3, TLR3, TLR7

GO Terms for genes affiliated with Juvenile Nasopharyngeal Angiofibroma

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Cellular components related to Juvenile Nasopharyngeal Angiofibroma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1early phagosomeGO:003200910.3TLR7, TLR9
2endolysosome membraneGO:003602010.1TLR3, TLR7, TLR9
3cell surfaceGO:00099869.7ENG, KIT, TGFB3, TLR3, VEGFA
4extracellular spaceGO:00056157.7ACTC1, BMP6, ENG, FGF2, KIT, PECAM1
5cytoplasmGO:00057376.4ACTC1, BMI1, BMP6, ENG, ESR1, FGF2

Biological processes related to Juvenile Nasopharyngeal Angiofibroma according to GeneCards Suite gene sharing:

(show all 33)
idNameGO IDScoreTop Affiliating Genes
1cell migration involved in sprouting angiogenesisGO:000204210.8FGF2, VEGFA
2cellular response to estrogen stimulusGO:007139110.7ESR1, MYC
3negative regulation of glucose importGO:004632510.7ESR1, MYC
4positive regulation of toll-like receptor signaling pathwayGO:003412310.6TLR3, TLR9
5positive regulation of cell divisionGO:005178110.5FGF2, TGFB3, VEGFA
6microglial cell activationGO:000177410.5TLR3, TLR7
7platelet degranulationGO:000257610.5PECAM1, TGFB3, VEGFA
8positive regulation of MAP kinase activityGO:004340610.4FGF2, KIT, VEGFA
9positive regulation of phospholipase C activityGO:001086310.4ESR1, FGF2, KIT
10ovarian follicle developmentGO:000154110.4KIT, MYC, VEGFA
11activation of MAPK activityGO:000018710.3FGF2, KIT, TGFB3
12positive regulation of SMAD protein import into nucleusGO:006039110.3BMP6, TGFB3
13positive regulation of fibroblast proliferationGO:004814610.2BMI1, ESR1, MYC
14positive regulation of endothelial cell proliferationGO:000193810.2BMP6, FGF2, VEGFA
15I-kappaB phosphorylationGO:000725210.1TLR3, TLR7, TLR9
16negative regulation of gene expressionGO:001062910.1ENG, ESR1, MYC, PGR
17positive regulation of chemokine productionGO:003272210.1TLR3, TLR7, TLR9
18positive regulation of protein phosphorylationGO:000193410.1ENG, FGF2, TLR3, VEGFA
19positive regulation of inflammatory responseGO:005072910.1TLR3, TLR7, TLR9
20positive regulation of interferon-alpha biosynthetic processGO:004535610.1TLR3, TLR7, TLR9
21positive regulation of interferon-beta biosynthetic processGO:004535910.1TLR3, TLR7, TLR9
22positive regulation of interferon-gamma biosynthetic processGO:004507810.1TLR3, TLR7, TLR9
23positive regulation of interleukin-6 productionGO:003275510.1TLR3, TLR7, TLR9
24positive regulation of interleukin-8 productionGO:003275710.1TLR3, TLR7, TLR9
25positive regulation of NF-kappaB import into nucleusGO:004234610.1TLR3, TLR7, TLR9
26toll-like receptor signaling pathwayGO:00022249.9TLR3, TLR7, TLR9
27positive regulation of pathway-restricted SMAD protein phosphorylationGO:00108629.9BMP6, ENG, TGFB3
28wound healingGO:00420609.7FGF2, PECAM1, TGFB3
29positive regulation of epithelial cell proliferationGO:00506799.7BMP6, ESR1, FGF2, MYC, VEGFA
30cellular response to mechanical stimulusGO:00712609.4BMP6, ENG, TLR3, TLR7
31inflammatory responseGO:00069549.1BMP6, KIT, TLR3, TLR7, TLR9
32positive regulation of gene expressionGO:00106289.1ACTC1, ENG, FGF2, KIT, TLR3, TLR9
33positive regulation of transcription from RNA polymerase II promoterGO:00459447.9BMP6, ENG, ESR1, FGF2, MYC, PGR

Molecular functions related to Juvenile Nasopharyngeal Angiofibroma according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1transforming growth factor beta bindingGO:005043110.4ENG, TGFB3
2siRNA bindingGO:003519710.2TLR7, TLR9
3type I transforming growth factor beta receptor bindingGO:00347139.9ENG, TGFB3
4cytokine activityGO:00051259.8BMP6, FGF2, TGFB3, VEGFA
5type II transforming growth factor beta receptor bindingGO:00051149.8ENG, TGFB3
6growth factor activityGO:00080839.7BMP6, FGF2, TGFB3, VEGFA
7transmembrane signaling receptor activityGO:00048889.3ENG, TLR3, TLR7, TLR9

Sources for Juvenile Nasopharyngeal Angiofibroma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet