MCID: JVN033
MIFTS: 39

Juvenile Nasopharyngeal Angiofibroma malady

Category: Rare diseases

Aliases & Classifications for Juvenile Nasopharyngeal Angiofibroma

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Sources:
30ICD10 via Orphanet, 53Orphanet, 67UMLS
See all MalaCards sources

Aliases & Descriptions for Juvenile Nasopharyngeal Angiofibroma:

Name: Juvenile Nasopharyngeal Angiofibroma 53
Nasopharyngeal Angiofibroma 67
 
Jna 53

Characteristics:

Orphanet epidemiological data:

53
juvenile nasopharyngeal angiofibroma:
Inheritance: Not applicable; Age of onset: Adolescent,Childhood

Classifications:



External Ids:

Orphanet53 ORPHA289596
ICD10 via Orphanet30 D10.6

Summaries for Juvenile Nasopharyngeal Angiofibroma

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MalaCards based summary: Juvenile Nasopharyngeal Angiofibroma, also known as nasopharyngeal angiofibroma, is related to nasopharyngitis and vulvar angiokeratoma, and has symptoms including dyspnea and headache. An important gene associated with Juvenile Nasopharyngeal Angiofibroma is VEGFA (Vascular Endothelial Growth Factor A), and among its related pathways are Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics and Vemurafenib Pathway, Pharmacodynamics. Affiliated tissues include endothelial and retina, and related mouse phenotypes are limbs/digits/tail and neoplasm.

Related Diseases for Juvenile Nasopharyngeal Angiofibroma

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Diseases related to Juvenile Nasopharyngeal Angiofibroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 102)
idRelated DiseaseScoreTop Affiliating Genes
1nasopharyngitis11.1
2vulvar angiokeratoma10.7ESR1, PGR
3central nervous system organ benign neoplasm10.7ESR1, PGR
4fallopian tube benign neoplasm10.7ESR1, PGR
5appendix leiomyoma10.7ESR1, PGR
6mixed cell adenoma10.7ESR1, PGR
7gelatinous ascites10.7ESR1, PGR
8deafness, autosomal dominant 8/1210.6ESR1, PGR
9perinatal intestinal perforation10.6ESR1, PGR
10lymphocytic vasculitis10.6PCNA, PGR
11trigeminal nerve disease10.6ESR1, PGR
12glottis verrucous carcinoma10.6ESR1, PGR
13adenosine monophosphate deaminase 1 deficiency10.6ESR1, PGR, VEGFA
14colorectal adenoma10.6FGF2, VEGFA
15chiari malformation type 310.6ACTC1, FGF2
16iridogoniodysgenesis and skeletal anomalies10.6ACTC1, VEGFA
17gastric small cell carcinoma10.6FGF2, PGR, VEGFA
18dental caries10.5ESR1, PGR, VEGFA
19ovarian wilms' cancer10.5ESR1, PGR, VEGFA
20bladder colonic type adenocarcinoma10.5ESR1, PGR
21developmental coordination disorder10.5ESR1, PECAM1, VEGFA
22lobular neoplasia10.5ESR1, PGR, VEGFA
23adenocarcinoma in situ10.5ESR1, PGR
24thoracic benign neoplasm10.5ESR1, PGR, TGFB3
25fallopian tube germ cell cancer10.5ACTC1, ESR1, PGR
26gastrointestinal system benign neoplasm10.5ESR1, PGR, TGFB3
27simple partial epilepsy10.5ACTC1, PCNA, PGR
28small intestinal sarcoma10.5ACTC1, ESR1, PGR
29bartholin's gland adenoid cystic carcinoma10.4ESR1, KIT, PGR
30asthma susceptibility 510.4ESR1, PGR
31infiltrative basal cell carcinoma10.4ESR1, KIT, PGR
32xq12-q13.3 duplication syndrome10.4ACTC1, KIT
33vibratory urticaria10.4ESR1, KIT, PGR
34vhl-related pheochromocytoma10.4ENG, ESR1
35prostate adenoid cystic carcinoma10.4KIT, PGR, VEGFA
36nerve fibre bundle defect10.4ESR1, KIT, PGR
37pancreatic serous cystic neoplasm10.4PGR, VEGFA
38epithelioid type angiomyolipoma10.4ESR1, KIT, PGR
39lung carcinoma in situ10.4ESR1, FGF2, PGR, VEGFA
40vulvar leiomyoma10.4ESR1, KIT, PGR
41enamel erosion10.4ENG, FGF2, VEGFA
42nodular degeneration of cornea10.4ESR1, FGF2, PGR, VEGFA
43spinal cord astrocytoma10.4ENG, VEGFA
44gallbladder angiosarcoma10.4KIT, MYC, PGR
45placental choriocarcinoma10.4FGF2, KIT, VEGFA
46gangliosidosis gm210.4KIT, MYC
47fallopian tube adenosarcoma10.4ESR1, KIT, PGR
48her2-receptor positive breast cancer10.4CYP19A1, ESR1, PGR
49retroperitoneum carcinoma10.4CYP19A1, ESR1, PGR
50leiomyosarcoma10.4ESR1, MYC, PGR, VEGFA

Graphical network of the top 20 diseases related to Juvenile Nasopharyngeal Angiofibroma:



Diseases related to juvenile nasopharyngeal angiofibroma

Symptoms for Juvenile Nasopharyngeal Angiofibroma

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UMLS symptoms related to Juvenile Nasopharyngeal Angiofibroma:


dyspnea, headache

Drugs & Therapeutics for Juvenile Nasopharyngeal Angiofibroma

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Juvenile Nasopharyngeal Angiofibroma

Genetic Tests for Juvenile Nasopharyngeal Angiofibroma

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Anatomical Context for Juvenile Nasopharyngeal Angiofibroma

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MalaCards organs/tissues related to Juvenile Nasopharyngeal Angiofibroma:

35
Endothelial, Retina

Animal Models for Juvenile Nasopharyngeal Angiofibroma or affiliated genes

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MGI Mouse Phenotypes related to Juvenile Nasopharyngeal Angiofibroma:

40 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053719.2ESR1, KIT, MYC, PGR, TGFB3, VEGFA
2MP:00020069.1ESR1, FGF2, KIT, MYC, PGR, TLR3
3MP:00053888.8ENG, ESR1, KIT, PECAM1, TGFB3, TLR3
4MP:00053678.1CYP19A1, ESR1, KIT, PECAM1, TLR7, TLR9
5MP:00053797.8CYP11A1, CYP19A1, ESR1, KIT, MYC, PCNA
6MP:00053907.7BMP6, CYP19A1, ESR1, FGF2, KIT, MYC
7MP:00053817.3CYP19A1, ENG, ESR1, KIT, MYC, PECAM1
8MP:00028737.1ACTC1, CYP11A1, CYP19A1, ENG, ESR1, KIT
9MP:00036317.0CYP11A1, CYP19A1, ENG, ESR1, FGF2, KIT
10MP:00053896.9BMP6, CYP11A1, CYP19A1, ESR1, FGF2, KIT
11MP:00053866.9CYP11A1, CYP19A1, ENG, ESR1, FGF2, KIT
12MP:00053856.8ACTC1, CYP19A1, ENG, ESR1, FGF2, KIT
13MP:00053696.8ACTC1, CYP11A1, CYP19A1, ENG, ESR1, FGF2
14MP:00053876.5CYP11A1, CYP19A1, ESR1, KIT, MYC, PCNA
15MP:00053786.3ACTC1, BMP6, CYP11A1, CYP19A1, ENG, ESR1
16MP:00053846.2ACTC1, CYP11A1, CYP19A1, ESR1, FGF2, KIT
17MP:00107685.9ACTC1, CYP11A1, ENG, ESR1, FGF2, KIT
18MP:00053975.8CYP11A1, CYP19A1, ENG, ESR1, FGF2, KIT
19MP:00053765.3ACTC1, CYP11A1, CYP19A1, ENG, ESR1, FGF2

Publications for Juvenile Nasopharyngeal Angiofibroma

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Articles related to Juvenile Nasopharyngeal Angiofibroma:

(show top 50)    (show all 295)
idTitleAuthorsYear
1
A Drastic Aftermath of Embolisation in Juvenile Nasopharyngeal Angiofibroma. (27833886)
2016
2
Juvenile nasopharyngeal angiofibroma. (27601836)
2016
3
In defence of transpalatal, transpalatal-circumaxillary (transpterygopalatine) and transpalatal-circumaxillary-sublabial approaches to lateral extensions of juvenile nasopharyngeal angiofibroma. (26940398)
2016
4
Bilateral, independent juvenile nasopharyngeal angiofibroma: case report. (26314415)
2015
5
Stridor: an unusual presentation of juvenile nasopharyngeal angiofibroma. (24711471)
2014
6
Endonasal endoscopic management of juvenile nasopharyngeal angiofibroma without angiographic embolization. (23271032)
2013
7
Juvenile nasopharyngeal angiofibroma: Vascular determinates for operative complications and tumor recurrence. (23929652)
2013
8
Bilateral non-superselective embolization with particles under transient occlusion of the internal carotid artery in the management of juvenile nasopharyngeal angiofibroma: technical note. (22903329)
2012
9
Endoscopic Coblation for the treatment of advanced juvenile nasopharyngeal angiofibroma. (23076852)
2012
10
An unusual case of epistaxis-juvenile nasopharyngeal angiofibroma. (20381990)
2012
11
Endoscopic resection of juvenile nasopharyngeal angiofibroma. (22472245)
2012
12
Role of Le Fort type I osteotomy approach in juvenile nasopharyngeal angiofibroma. (21880465)
2011
13
Coblation-assisted endonasal endoscopic resection of juvenile nasopharyngeal angiofibroma. (21729442)
2011
14
Transnasal endoscopic management of recurrent juvenile nasopharyngeal angiofibroma. (21397958)
2011
15
Juvenile nasopharyngeal angiofibroma. (21819885)
2011
16
Reducing intraoperative bleeding of juvenile nasopharyngeal angiofibroma. (21492601)
2010
17
Radiology quiz case 2. Juvenile nasopharyngeal angiofibroma (JNA), Radkowski grade Ib. (20644076)
2010
18
A case of central retinal artery occlusion following embolization procedure for juvenile nasopharyngeal angiofibroma. (20689199)
2010
19
Juvenile nasopharyngeal angiofibroma: current treatment modalities and future considerations. (23120720)
2010
20
Efficacy of selective percutaneous embolization for the treatment of intractable posterior epistaxis and juvenile nasopharyngeal angiofibroma (JNA). (19922097)
2009
21
Juvenile nasopharyngeal angiofibroma: clinical factors associated with recurrence and proposal of a staging system. (18623035)
2008
22
Wnt pathway, angiogenetic and hormonal markers in sporadic and familial adenomatous polyposis-associated juvenile nasopharyngeal angiofibromas (JNA). (18227724)
2008
23
Surgical management of juvenile nasopharyngeal angiofibroma without angiographic embolization. (19010758)
2008
24
Juvenile nasopharyngeal angiofibroma: an immunohistochemical characterisation of the stromal cell. (18446631)
2008
25
Epstein-Barr virus and human herpes virus-8 are not associated with juvenile nasopharyngeal angiofibroma. (20614308)
2008
26
Repair oronasal fistula in a treated juvenile nasopharyngeal angiofibroma patient. (17825778)
2007
27
Endoscopic surgery for juvenile nasopharyngeal angiofibroma: where are the limits? (16467630)
2006
28
Orbital involvement in juvenile nasopharyngeal angiofibroma: prevalence and treatment. (15266144)
2004
29
Tissue maturation during the growth of juvenile nasopharyngeal angiofibroma. (14763569)
2004
30
Juvenile nasopharyngeal angiofibroma: the routes of invasion. (14750351)
2003
31
Craniofacial resection of advanced juvenile nasopharyngeal angiofibroma. (12220215)
2002
32
Diagnosis and treatment of juvenile nasopharyngeal angiofibroma. (11374252)
2001
33
Juvenile nasopharyngeal angiofibroma. (10923344)
2000
34
Radiation therapy as an alternative to surgery in the management of intracranial juvenile nasopharyngeal angiofibroma. (8300314)
1993
35
Surgical experience with juvenile nasopharyngeal angiofibroma. (1337963)
1992
36
Juvenile nasopharyngeal angiofibroma: a trap for the unwary. (1322461)
1992
37
Juvenile nasopharyngeal angiofibroma in a static population: the implications of misdiagnosis. (2178075)
1990
38
The treatment of advanced juvenile nasopharyngeal angiofibroma. (2553648)
1989
39
Juvenile nasopharyngeal angiofibroma: an update of the UCLA experience, 1960-1985. (3339927)
1988
40
Juvenile nasopharyngeal angiofibroma. (3025797)
1986
41
Juvenile nasopharyngeal angiofibroma: an unusual presentation in the oral cavity. (2989749)
1985
42
Oronasal fistula--a possible complication of preoperative embolization in the management of juvenile nasopharyngeal angiofibroma. (6308111)
1983
43
Juvenile nasopharyngeal angiofibroma. (6256588)
1980
44
Juvenile nasopharyngeal angiofibroma: control rates and treatment costs. (6254910)
1980
45
Juvenile nasopharyngeal angiofibroma. A report of seven cases. (205902)
1978
46
Juvenile nasopharyngeal angiofibroma. An unusual presentation as an oral mass. (197910)
1977
47
X-ray of the month: juvenile nasopharyngeal angiofibroma. (180866)
1976
48
Angiographic evaluation of the regression of an extensive juvenile nasopharyngeal angiofibroma after radiation therapy: a case report with therapeutic implications. (4373112)
1974
49
Juvenile nasopharyngeal angiofibroma. (4344430)
1972
50
Juvenile nasopharyngeal angiofibroma. (13886154)
1962

Variations for Juvenile Nasopharyngeal Angiofibroma

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Expression for genes affiliated with Juvenile Nasopharyngeal Angiofibroma

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Search GEO for disease gene expression data for Juvenile Nasopharyngeal Angiofibroma.

Pathways for genes affiliated with Juvenile Nasopharyngeal Angiofibroma

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Pathways related to Juvenile Nasopharyngeal Angiofibroma according to GeneCards Suite gene sharing:

(show all 29)
idSuper pathwaysScoreTop Affiliating Genes
19.8CYP19A1, ESR1
29.8FGF2, MYC, VEGFA
39.7FGF2, TGFB3, VEGFA
49.6PECAM1, TGFB3, TLR9
59.6ACTC1, FGF2, KIT
69.5ESR1, FGF2, MYC, VEGFA
79.5BMI1, FGF2, VEGFA
89.4BMP6, FGF2, VEGFA
9
Show member pathways
9.4TLR3, TLR7, TLR9
109.4TLR3, TLR7, TLR9
119.3CYP19A1, ESR1, MYC, VEGFA
129.3ESR1, FGF2, MYC, PCNA, VEGFA
13
Show member pathways
9.3KIT, MYC, PCNA, TGFB3
149.3ENG, ESR1, MYC, TGFB3
159.3ENG, ESR1, MYC, TGFB3
16
Show member pathways
9.3ENG, FGF2, PECAM1, TGFB3
179.2BMI1, FGF2, MYC, VEGFA
189.2KIT, TLR7, TLR9
19
Show member pathways
9.1PCNA, TLR3, TLR7, TLR9
209.1FGF2, KIT, MYC, TGFB3, VEGFA
21
Show member pathways
9.1TGFB3, TLR3, TLR7, TLR9
228.6BMI1, BMP6, ENG, TGFB3
238.6BMP6, CYP11A1, CYP19A1
248.6MYC, TGFB3, TLR3, TLR7, TLR9, VEGFA
258.5BMP6, ENG, FGF2, KIT, TGFB3
26
Show member pathways
8.5MYC, PCNA, TGFB3, TLR3, TLR7, TLR9
27
Show member pathways
8.2BMP6, FGF2, TGFB3, TLR3, TLR7, TLR9
288.2BMI1, KIT, PECAM1, TLR3, TLR7, TLR9
29
Show member pathways
7.8BMP6, FGF2, KIT, TGFB3, TLR3, TLR7

GO Terms for genes affiliated with Juvenile Nasopharyngeal Angiofibroma

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Cellular components related to Juvenile Nasopharyngeal Angiofibroma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1early phagosomeGO:003200910.4TLR7, TLR9
2endolysosome membraneGO:003602010.0TLR3, TLR7, TLR9
3cell surfaceGO:00099869.0ENG, KIT, TGFB3, TLR3, VEGFA
4extracellular spaceGO:00056157.7ACTC1, BMP6, ENG, FGF2, KIT, PECAM1
5cytoplasmGO:00057375.6ACTC1, BMI1, BMP6, ENG, ESR1, FGF2

Biological processes related to Juvenile Nasopharyngeal Angiofibroma according to GeneCards Suite gene sharing:

(show all 33)
idNameGO IDScoreTop Affiliating Genes
1cell migration involved in sprouting angiogenesisGO:000204210.7FGF2, VEGFA
2negative regulation of glucose importGO:004632510.7ESR1, MYC
3positive regulation of toll-like receptor signaling pathwayGO:003412310.6TLR3, TLR9
4cellular response to estrogen stimulusGO:007139110.5ESR1, MYC
5positive regulation of phospholipase C activityGO:001086310.4ESR1, FGF2, KIT
6positive regulation of cell divisionGO:005178110.3FGF2, TGFB3, VEGFA
7platelet degranulationGO:000257610.2PECAM1, TGFB3, VEGFA
8microglial cell activationGO:000177410.2TLR3, TLR7
9positive regulation of SMAD protein import into nucleusGO:006039110.0BMP6, TGFB3
10positive regulation of interferon-alpha biosynthetic processGO:004535610.0TLR3, TLR7, TLR9
11positive regulation of interferon-beta biosynthetic processGO:004535910.0TLR3, TLR7, TLR9
12positive regulation of chemokine productionGO:003272210.0TLR3, TLR7, TLR9
13positive regulation of MAP kinase activityGO:004340610.0FGF2, KIT, VEGFA
14positive regulation of NF-kappaB import into nucleusGO:004234610.0TLR3, TLR7, TLR9
15positive regulation of interferon-gamma biosynthetic processGO:00450789.9TLR3, TLR7, TLR9
16positive regulation of endothelial cell proliferationGO:00019389.9BMP6, FGF2, VEGFA
17positive regulation of fibroblast proliferationGO:00481469.9BMI1, ESR1, MYC
18positive regulation of inflammatory responseGO:00507299.9TLR3, TLR7, TLR9
19positive regulation of protein phosphorylationGO:00019349.9ENG, FGF2, TLR3, VEGFA
20I-kappaB phosphorylationGO:00072529.8TLR3, TLR7, TLR9
21toll-like receptor signaling pathwayGO:00022249.8TLR3, TLR7, TLR9
22ovarian follicle developmentGO:00015419.8KIT, MYC, VEGFA
23positive regulation of interleukin-6 productionGO:00327559.8TLR3, TLR7, TLR9
24wound healingGO:00420609.7FGF2, PECAM1, TGFB3
25activation of MAPK activityGO:00001879.7FGF2, KIT, TGFB3
26positive regulation of interleukin-8 productionGO:00327579.7TLR3, TLR7, TLR9
27positive regulation of pathway-restricted SMAD protein phosphorylationGO:00108629.6BMP6, ENG, TGFB3
28negative regulation of gene expressionGO:00106299.6ENG, ESR1, MYC, PGR
29positive regulation of epithelial cell proliferationGO:00506799.2BMP6, ESR1, FGF2, MYC, VEGFA
30cellular response to mechanical stimulusGO:00712609.1BMP6, ENG, TLR3, TLR7
31inflammatory responseGO:00069548.7BMP6, KIT, TLR3, TLR7, TLR9
32positive regulation of gene expressionGO:00106288.2ACTC1, ENG, FGF2, KIT, TLR3, TLR9
33positive regulation of transcription from RNA polymerase II promoterGO:00459447.4BMP6, ENG, ESR1, FGF2, MYC, PGR

Molecular functions related to Juvenile Nasopharyngeal Angiofibroma according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1type I transforming growth factor beta receptor bindingGO:003471310.3ENG, TGFB3
2type II transforming growth factor beta receptor bindingGO:000511410.3ENG, TGFB3
3transforming growth factor beta bindingGO:005043110.2ENG, TGFB3
4siRNA bindingGO:00351979.5TLR7, TLR9
5cytokine activityGO:00051259.1BMP6, FGF2, TGFB3, VEGFA
6transmembrane signaling receptor activityGO:00048888.9ENG, TLR3, TLR7, TLR9
7growth factor activityGO:00080838.8BMP6, FGF2, TGFB3, VEGFA

Sources for Juvenile Nasopharyngeal Angiofibroma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet