MCID: JVN033
MIFTS: 37

Juvenile Nasopharyngeal Angiofibroma malady

Cancer diseases, Rare diseases categories

Aliases & Classifications for Juvenile Nasopharyngeal Angiofibroma

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Sources:
51Orphanet, 28ICD10 via Orphanet
See all sources

Aliases & Descriptions for Juvenile Nasopharyngeal Angiofibroma:

Name: Juvenile Nasopharyngeal Angiofibroma 51
 
Jna 51


Classifications:

Orphanet: 51 
Rare tumors


External Ids:

Orphanet51 289596
ICD10 via Orphanet28 D10.6

Summaries for Juvenile Nasopharyngeal Angiofibroma

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MalaCards based summary: Juvenile Nasopharyngeal Angiofibroma, also known as jna, is related to nasopharyngitis and familial adenomatous polyposis. An important gene associated with Juvenile Nasopharyngeal Angiofibroma is PCNA (Proliferating Cell Nuclear Antigen), and among its related pathways are Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics and Vemurafenib Pathway, Pharmacodynamics. Affiliated tissues include endothelial and retina, and related mouse phenotypes are limbs/digits/tail and tumorigenesis.

Related Diseases for Juvenile Nasopharyngeal Angiofibroma

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Diseases related to Juvenile Nasopharyngeal Angiofibroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 103)
idRelated DiseaseScoreTop Affiliating Genes
1nasopharyngitis11.5
2familial adenomatous polyposis10.6
3retinitis10.6
4endotheliitis10.6
5central retinal artery occlusion10.5
6retinal artery occlusion10.5
7vulvar melanoma10.3ESR1, PGR
8childhood teratocarcinoma of the testis10.3ESR1, PGR
9rectum rhabdomyosarcoma10.3ESR1, PGR
10vestibulocochlear nerve disease10.3ESR1, PGR
11vulvar disease10.3ESR1, PGR
12vulvar sarcoma10.3ESR1, PGR
13glaucoma iridogoniodysgenesia10.3ESR1, PGR
14vulvar leiomyosarcoma10.3ACTC1, ESR1
15tuberous sclerosis10.3ESR1, PGR
16alopecia10.3
17foster-kennedy syndrome10.3
18fibrous histiocytoma10.3
19esotropia10.3
20fibrosarcoma10.3
21histiocytoma10.3
22vascular malformation10.3
23lymphatic neoplasm10.3PCNA, PGR
24progesterone resistance10.3ESR1, PGR
25sclerosing bone dysplasia mental retardation10.3ACTC1, FGF2
26sarcomatoid basal cell carcinoma10.3ESR1, PGR
27perineural angioma10.3ESR1, PGR
28iodine antenatal infection10.3ACTC1, VEGFA
29cowden disease10.3ACTC1, PCNA, PGR
30metachronous kidney wilms' tumor10.3ESR1, PGR, VEGFA
31malignant cystic nephroma10.3ESR1, PGR
32bartonellosis10.3ESR1, PGR
33lung leiomyosarcoma10.3ACTC1, ESR1, PGR
34papillary extrahepatic bile duct adenocarcinoma10.3ESR1, PGR
35malignant peripheral nerve sheath tumor10.3ESR1, PGR, VEGFA
36ovary sarcoma10.3ESR1, PGR, VEGFA
37heart lymphoma10.3FGF2, PGR, VEGFA
38silver-russell syndrome due to maternal uniparental disomy of chromosome 710.2PECAM1, VEGFA
39vagina leiomyosarcoma10.2ESR1, PGR
40breast fibroadenoma10.2ESR1, PGR, VEGFA
41hydrophthalmos10.2ESR1, PECAM1, VEGFA
42warty dyskeratoma10.2FGF2, PECAM1, VEGFA
43germ cell and embryonal cancer10.2CYP19A1, ESR1, PGR
44subclavian steal syndrome10.2CYP19A1, ESR1, PGR
45spigelian hernia-cryptorchidism syndrome10.2ACTC1, KIT
46adrenal rest tumor10.2ESR1, FGF2, PGR, VEGFA
47endometriosis in scar of skin10.2CYP19A1, ESR1, PGR
48endometrial stromal tumor10.2ESR1, FGF2, PGR, VEGFA
49benign multicystic peritoneal mesothelioma10.2ACTC1, CYP19A1, PGR
50her2-receptor positive breast cancer10.2CYP19A1, ESR1, PGR

Graphical network of the top 20 diseases related to Juvenile Nasopharyngeal Angiofibroma:



Diseases related to juvenile nasopharyngeal angiofibroma

Symptoms for Juvenile Nasopharyngeal Angiofibroma

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Drugs & Therapeutics for Juvenile Nasopharyngeal Angiofibroma

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Juvenile Nasopharyngeal Angiofibroma

Genetic Tests for Juvenile Nasopharyngeal Angiofibroma

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Anatomical Context for Juvenile Nasopharyngeal Angiofibroma

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MalaCards organs/tissues related to Juvenile Nasopharyngeal Angiofibroma:

33
Endothelial, Retina

Animal Models for Juvenile Nasopharyngeal Angiofibroma or affiliated genes

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MGI Mouse Phenotypes related to Juvenile Nasopharyngeal Angiofibroma:

38 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.2BMI1, ESR1, KIT, MYC, PGR, TGFB3
2MP:00020067.8BMI1, ESR1, FGF2, KIT, MYC, PGR
3MP:00053817.8BMI1, ESR1, KIT, MYC, PECAM1, TGFB3
4MP:00053807.7BMI1, ENG, ESR1, KIT, MYC, PGR
5MP:00053887.5BMI1, ENG, ESR1, KIT, PECAM1, TGFB3
6MP:00053906.7BMI1, BMP6, CYP19A1, ESR1, FGF2, KIT
7MP:00028736.7ACTC1, BMI1, CYP11A1, CYP19A1, ENG, KIT
8MP:00053796.6BMI1, CYP11A1, CYP19A1, ESR1, KIT, MYC
9MP:00053696.5ACTC1, CYP11A1, CYP19A1, ENG, ESR1, FGF2
10MP:00053866.4BMI1, CYP11A1, CYP19A1, ESR1, FGF2, KIT
11MP:00053786.2ACTC1, BMI1, BMP6, CYP11A1, CYP19A1, ENG
12MP:00053856.2ACTC1, BMI1, CYP19A1, ENG, ESR1, FGF2
13MP:00036316.1BMI1, CYP11A1, CYP19A1, ENG, ESR1, FGF2
14MP:00053896.1BMP6, CYP11A1, CYP19A1, ESR1, FGF2, KIT
15MP:00053875.8BMI1, CYP11A1, CYP19A1, ESR1, KIT, MYC
16MP:00107685.4ACTC1, BMI1, CYP11A1, ENG, ESR1, FGF2
17MP:00053845.3ACTC1, BMI1, CYP11A1, CYP19A1, ENG, ESR1
18MP:00053765.2ACTC1, CYP11A1, CYP19A1, ENG, ESR1, FGF2
19MP:00053975.0BMI1, CYP11A1, CYP19A1, ENG, ESR1, FGF2

Publications for Juvenile Nasopharyngeal Angiofibroma

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Articles related to Juvenile Nasopharyngeal Angiofibroma:

(show top 50)    (show all 276)
idTitleAuthorsYear
1
Endoscopic graduated multiangle, multicorridor resection of juvenile nasopharyngeal angiofibroma: an individualized, tailored, multicorridor skull base approach. (26566205)
2015
2
Bilateral, independent juvenile nasopharyngeal angiofibroma: case report. (26314415)
2015
3
Combined percutaneous and transarterial devascularisation of juvenile nasopharyngeal angiofibroma with protection of internal carotid artery: A modification of the technique. (25991005)
2015
4
Microspheres embolization of juvenile nasopharyngeal angiofibroma in an adult. (25437676)
2014
5
Imaging in the diagnosis of juvenile nasopharyngeal angiofibroma. (23878770)
2013
6
Tenascin-C, GLUT-1, and syndecan-2 expression in juvenile nasopharyngeal angiofibroma: correlations to vessel density and tumor stage. (22791513)
2013
7
Endonasal endoscopic management of juvenile nasopharyngeal angiofibroma without angiographic embolization. (23271032)
2013
8
Bilateral non-superselective embolization with particles under transient occlusion of the internal carotid artery in the management of juvenile nasopharyngeal angiofibroma: technical note. (22903329)
2012
9
Juvenile nasopharyngeal angiofibroma with intradural extension. (22030982)
2011
10
Role of Le Fort type I osteotomy approach in juvenile nasopharyngeal angiofibroma. (21880465)
2011
11
Endoscopically assisted intratumoral embolization of juvenile nasopharyngeal angiofibroma using Onyx. (21631195)
2011
12
The changing surgical management of juvenile nasopharyngeal angiofibroma. (20848119)
2011
13
Reducing intraoperative bleeding of juvenile nasopharyngeal angiofibroma. (21492601)
2010
14
Management of juvenile nasopharyngeal angiofibroma: a five year retrospective study. (22319699)
2010
15
Efficacy of selective percutaneous embolization for the treatment of intractable posterior epistaxis and juvenile nasopharyngeal angiofibroma (JNA). (19922097)
2009
16
Juvenile nasopharyngeal angiofibroma: clinical factors associated with recurrence and proposal of a staging system. (18623035)
2008
17
Pyocele of the lachrymal sac: A late and unusual complication after surgery for a juvenile nasopharyngeal angiofibroma. (19668408)
2008
18
Lacrimal hyposecretion: a surgical complication of juvenile nasopharyngeal angiofibroma. (19144296)
2008
19
Wnt pathway, angiogenetic and hormonal markers in sporadic and familial adenomatous polyposis-associated juvenile nasopharyngeal angiofibromas (JNA). (18227724)
2008
20
Frequent chromosomal gains in recurrent juvenile nasopharyngeal angiofibroma. (17556070)
2007
21
Expression of PCNA, VEGF and bFGF in endothelial cells of juvenile nasopharyngeal angiofibroma]. (17285972)
2006
22
Orbital involvement in juvenile nasopharyngeal angiofibroma: prevalence and treatment. (15266144)
2004
23
Tissue maturation during the growth of juvenile nasopharyngeal angiofibroma. (14763569)
2004
24
Frequent beta-catenin mutations in juvenile nasopharyngeal angiofibromas. (11238055)
2001
25
Diagnosis and treatment of juvenile nasopharyngeal angiofibroma. (11374252)
2001
26
Immunolocalization of activated transforming growth factor beta1 in juvenile nasopharyngeal angiofibroma. (10864108)
2000
27
Juvenile nasopharyngeal angiofibroma. (10410346)
1999
28
Radiation therapy as an alternative to surgery in the management of intracranial juvenile nasopharyngeal angiofibroma. (8300314)
1993
29
Surgical experience with juvenile nasopharyngeal angiofibroma. (1337963)
1992
30
Juvenile nasopharyngeal angiofibroma: a trap for the unwary. (1322461)
1992
31
Juvenile nasopharyngeal angiofibroma in a static population: the implications of misdiagnosis. (2178075)
1990
32
Preoperative embolisation in the management of juvenile nasopharyngeal angiofibroma. (2561258)
1989
33
The treatment of advanced juvenile nasopharyngeal angiofibroma. (2553648)
1989
34
Juvenile nasopharyngeal angiofibroma. (3025797)
1986
35
Juvenile nasopharyngeal angiofibroma: an unusual presentation in the oral cavity. (2989749)
1985
36
Postirradiation malignant fibrous histiocytoma arising in juvenile nasopharyngeal angiofibroma and producing alpha-1-antitrypsin. (6327493)
1984
37
A few points in the management of juvenile nasopharyngeal angiofibroma. (6325570)
1984
38
Oronasal fistula--a possible complication of preoperative embolization in the management of juvenile nasopharyngeal angiofibroma. (6308111)
1983
39
Juvenile nasopharyngeal angiofibroma--the preferred treatment. (6301001)
1983
40
Clinicopathologic conferences. Case 46, Part II: Juvenile nasopharyngeal angiofibroma. (6306189)
1983
41
Juvenile nasopharyngeal angiofibroma. (6256588)
1980
42
Juvenile nasopharyngeal angiofibroma. (6255615)
1980
43
Juvenile nasopharyngeal angiofibroma. A report of seven cases. (205902)
1978
44
Juvenile nasopharyngeal angiofibroma. (4344430)
1972
45
Juvenile nasopharyngeal angiofibroma. (4338568)
1972
46
Further experience in treatment of juvenile nasopharyngeal angiofibroma. (4305190)
1969
47
Juvenile nasopharyngeal angiofibroma. a theory of pathogenesis. (14442741)
1959
48
Sarcomatous transformation of a juvenile, nasopharyngeal angiofibroma. (13532703)
1958
49
Juvenile nasopharyngeal angiofibroma. (13087657)
1953
50
Juvenile Nasopharyngeal Angiofibroma. (17859097)
1948

Variations for Juvenile Nasopharyngeal Angiofibroma

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Expression for genes affiliated with Juvenile Nasopharyngeal Angiofibroma

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Search GEO for disease gene expression data for Juvenile Nasopharyngeal Angiofibroma.

Pathways for genes affiliated with Juvenile Nasopharyngeal Angiofibroma

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Pathways related to Juvenile Nasopharyngeal Angiofibroma according to GeneCards Suite gene sharing:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CYP19A1, ESR1
29.7FGF2, MYC, VEGFA
39.6FGF2, TGFB3, VEGFA
4
Show member pathways
9.6TLR3, TLR7, TLR9
59.6TLR3, TLR7, TLR9
69.5BMP6, FGF2, VEGFA
79.5PECAM1, TGFB3, TLR9
89.5ESR1, FGF2, MYC, VEGFA
99.3CYP19A1, ESR1, MYC, VEGFA
10
TGF-beta signaling pathway (KEGG)
Show member pathways
9.3CYP19A1, ESR1, MYC, VEGFA
119.2ESR1, FGF2, MYC, PCNA, VEGFA
12
Show member pathways
9.2TGFB3, TLR3, TLR7, TLR9
139.2ACTC1, FGF2, KIT
149.1ENG, ESR1, MYC, TGFB3
159.1ENG, ESR1, MYC, TGFB3
16
Angiogenesis (CST)
Show member pathways
9.1ENG, ESR1, MYC, TGFB3
178.9BMP6, CYP11A1, CYP19A1
18
Show member pathways
8.8KIT, MYC, PCNA, TGFB3
19
Show member pathways
8.7MYC, PCNA, TGFB3, TLR3, TLR7, TLR9
208.7MYC, TGFB3, TLR3, TLR7, TLR9, VEGFA
218.5FGF2, KIT, MYC, TGFB3, VEGFA
22
Show member pathways
8.4BMP6, FGF2, TGFB3, TLR3, TLR7, TLR9
237.9BMI1, KIT, PECAM1, TLR3, TLR7, TLR9
24
Show member pathways
7.6BMP6, FGF2, KIT, TGFB3, TLR3, TLR7

GO Terms for genes affiliated with Juvenile Nasopharyngeal Angiofibroma

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Cellular components related to Juvenile Nasopharyngeal Angiofibroma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1early phagosomeGO:003200910.5TLR7, TLR9
2endolysosome membraneGO:003602010.3TLR3, TLR7, TLR9
3cell surfaceGO:00099868.2ENG, KIT, TGFB3, TLR3, VEGFA
4extracellular spaceGO:00056157.0ACTC1, BMP6, ENG, FGF2, KIT, PECAM1
5cytoplasmGO:00057375.7ACTC1, BMI1, BMP6, ENG, ESR1, FGF2

Biological processes related to Juvenile Nasopharyngeal Angiofibroma according to GeneCards Suite gene sharing:

(show all 33)
idNameGO IDScoreTop Affiliating Genes
1cell migration involved in sprouting angiogenesisGO:000204210.6FGF2, VEGFA
2positive regulation of blood vessel endothelial cell migrationGO:004353610.6FGF2, VEGFA
3positive regulation of toll-like receptor signaling pathwayGO:003412310.5TLR3, TLR9
4detection of hypoxiaGO:007048310.4ENG, TGFB3
5androgen metabolic processGO:000820910.3CYP19A1, ESR1
6positive regulation of cell divisionGO:005178110.2FGF2, TGFB3, VEGFA
7positive regulation of SMAD protein import into nucleusGO:006039110.2BMP6, TGFB3
8I-kappaB phosphorylationGO:000725210.2TLR3, TLR7, TLR9
9positive regulation of chemokine productionGO:003272210.2TLR3, TLR7, TLR9
10positive regulation of interferon-alpha biosynthetic processGO:004535610.2TLR3, TLR7, TLR9
11positive regulation of interferon-beta biosynthetic processGO:004535910.2TLR3, TLR7, TLR9
12positive regulation of NF-kappaB import into nucleusGO:004234610.2TLR3, TLR7, TLR9
13estrogen biosynthetic processGO:000670310.1CYP11A1, CYP19A1
14positive regulation of interleukin-8 productionGO:003275710.1TLR3, TLR7, TLR9
15positive regulation of interferon-gamma biosynthetic processGO:004507810.1TLR3, TLR7, TLR9
16platelet degranulationGO:000257610.1PECAM1, TGFB3, VEGFA
17positive regulation of inflammatory responseGO:005072910.1TLR3, TLR7, TLR9
18positive regulation of interleukin-6 productionGO:003275510.0TLR3, TLR7, TLR9
19growthGO:00400079.9BMP6, TGFB3, VEGFA
20positive regulation of fibroblast proliferationGO:00481469.9BMI1, ESR1, MYC
21positive regulation of endothelial cell proliferationGO:00019389.9BMP6, FGF2, VEGFA
22positive regulation of phospholipase C activityGO:00108639.8ESR1, FGF2, KIT
23cellular response to mechanical stimulusGO:00712609.8BMP6, TLR3, TLR7
24positive regulation of epithelial cell proliferationGO:00506799.7BMP6, FGF2, MYC, VEGFA
25positive regulation of pathway-restricted SMAD protein phosphorylationGO:00108629.7BMP6, ENG, TGFB3
26response to estrogenGO:00436279.5CYP11A1, ESR1, TGFB3
27positive regulation of MAP kinase activityGO:00434069.5FGF2, KIT, VEGFA
28wound healingGO:00420609.2ENG, FGF2, PECAM1, TGFB3
29inflammatory responseGO:00069548.6BMP6, KIT, TLR3, TLR7, TLR9
30male gonad developmentGO:00085848.5CYP11A1, ESR1, KIT
31positive regulation of gene expressionGO:00106288.5ACTC1, FGF2, KIT, TLR3, TLR9, VEGFA
32signal transductionGO:00071657.7ESR1, FGF2, KIT, PECAM1, PGR, TLR3
33positive regulation of transcription from RNA polymerase II promoterGO:00459447.3BMP6, ENG, ESR1, FGF2, MYC, PGR

Molecular functions related to Juvenile Nasopharyngeal Angiofibroma according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1siRNA bindingGO:003519710.4TLR7, TLR9
2type I transforming growth factor beta receptor bindingGO:003471310.2ENG, TGFB3
3type II transforming growth factor beta receptor bindingGO:000511410.2ENG, TGFB3
4transforming growth factor beta bindingGO:005043110.1ENG, TGFB3
5transmembrane signaling receptor activityGO:00048889.5ENG, TLR3, TLR7, TLR9
6cytokine activityGO:00051259.4BMP6, FGF2, TGFB3, VEGFA
7growth factor activityGO:00080839.3BMP6, FGF2, TGFB3, VEGFA
8identical protein bindingGO:00428029.2ESR1, PCNA, TGFB3, TLR3, VEGFA

Sources for Juvenile Nasopharyngeal Angiofibroma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet