MCID: JVN033
MIFTS: 40

Juvenile Nasopharyngeal Angiofibroma malady

Categories: Cancer diseases, Rare diseases

Aliases & Classifications for Juvenile Nasopharyngeal Angiofibroma

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Sources:
51Orphanet, 28ICD10 via Orphanet
See all MalaCards sources

Aliases & Descriptions for Juvenile Nasopharyngeal Angiofibroma:

Name: Juvenile Nasopharyngeal Angiofibroma 51
 
Jna 51

Classifications:

Orphanet: 51 
Rare tumors


External Ids:

Orphanet51 289596
ICD10 via Orphanet28 D10.6

Summaries for Juvenile Nasopharyngeal Angiofibroma

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MalaCards based summary: Juvenile Nasopharyngeal Angiofibroma, also known as jna, is related to homocystinuria and hematopoietic stem cell transplantation. An important gene associated with Juvenile Nasopharyngeal Angiofibroma is PCNA (Proliferating Cell Nuclear Antigen), and among its related pathways are Th17 Differentiation Pathway and IL27-mediated signaling events. Affiliated tissues include lung, t cells and brain, and related mouse phenotypes are no phenotypic analysis and endocrine/exocrine gland.

Related Diseases for Juvenile Nasopharyngeal Angiofibroma

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Diseases related to Juvenile Nasopharyngeal Angiofibroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 296)
idRelated DiseaseScoreTop Affiliating Genes
1homocystinuria30.5BMI1, MYC, VEGFA
2hematopoietic stem cell transplantation29.6BMI1, ENG, KIT, VEGFA
3hepatocellular carcinoma29.1FGF2, KIT, MYC, PCNA, VEGFA
4breast cancer28.3BMP6, ESR1, FGF2, KIT, MYC, PCNA
5lung cancer10.6
6lymphoma10.5
7syringoma10.5ESR1, PGR
8endocrine organ benign neoplasm10.5ESR1, PGR
9cervical benign neoplasm10.5ESR1, PGR
10large bowel leiomyoma10.5ESR1, PGR
11bile duct cystadenoma10.5ESR1, PGR
12glaucoma iridogoniodysgenesia10.5ESR1, PGR
13venous tributary occlusion of retina10.5ESR1, PGR
14deafness, autosomal dominant 8/1210.5ESR1, PGR
15peroneal nerve paralysis10.5ESR1, PGR
16situs inversus10.5ESR1, PGR
17vulvar squamous papilloma10.5ESR1, PGR
18childhood choriocarcinoma of the ovary10.5ESR1, PGR
19ureter adenocarcinoma10.5ESR1, PGR
20dental pulp calcification10.5ESR1, PGR
21spondylitis10.5ESR1, PGR
22vulvar alveolar soft part sarcoma10.5ESR1, PGR
23pancreatic cystadenoma10.5PGR, VEGFA
24rectum mucinous adenocarcinoma10.5ESR1, PGR
25colorectal cancer10.5
26fibroma10.5
27ossifying fibroma10.5
28childhood mediastinal neurogenic tumor10.5ESR1, PGR
29apocrine adenosis of breast10.4ESR1, PGR
30retroperitoneal sarcoma10.4ESR1, PGR
31benign multicystic peritoneal mesothelioma10.4ACTC1, PGR
32uterine corpus adenosarcoma10.4ESR1, PGR
33renal pelvis squamous cell carcinoma10.4ESR1, PGR
34sciatic neuropathy10.4ESR1, PGR
35adult mesoblastic nephroma10.4ACTC1, PGR
36intraventricular meningioma10.4ESR1, PGR
37ovarian mucinous cystadenocarcinoma10.4ACTC1, PCNA
38large cell acanthoma10.4ESR1, PGR
39leukemia10.4
40sarcoma10.4
41encephalitis10.4
42endotheliitis10.4
43primary gastrointestinal melanoma10.4MYC, VEGFA
44breast metaplastic carcinoma10.4ESR1, PGR
45internal auditory canal lipoma10.4ESR1, PGR
46prostatic cyst10.4ESR1, PCNA, PGR
47adenosarcoma of the uterus10.4ESR1, PGR, VEGFA
48ovary epithelial cancer10.3ESR1, PGR, VEGFA
49ovarian wilms' cancer10.3ESR1, PGR, VEGFA
50leptospirosis10.3ESR1, PGR, VEGFA

Graphical network of the top 20 diseases related to Juvenile Nasopharyngeal Angiofibroma:



Diseases related to juvenile nasopharyngeal angiofibroma

Symptoms for Juvenile Nasopharyngeal Angiofibroma

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Drugs & Therapeutics for Juvenile Nasopharyngeal Angiofibroma

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Juvenile Nasopharyngeal Angiofibroma

Genetic Tests for Juvenile Nasopharyngeal Angiofibroma

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Anatomical Context for Juvenile Nasopharyngeal Angiofibroma

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MalaCards organs/tissues related to Juvenile Nasopharyngeal Angiofibroma:

33
Lung, T cells, Brain, Breast, Neutrophil, Colon, Prostate

Animal Models for Juvenile Nasopharyngeal Angiofibroma or affiliated genes

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MGI Mouse Phenotypes related to Juvenile Nasopharyngeal Angiofibroma:

38 (show all 14)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.6ESR1, KIT, MYC, PCNA, PGR, VEGFA
2MP:00053798.3ESR1, KIT, MYC, PCNA, PGR, TLR3
3MP:00028738.1ACTC1, ENG, ESR1, KIT, MYC, PGR
4MP:00020067.9ESR1, FGF2, KIT, MYC, PGR, TLR3
5MP:00053907.3BMP6, ESR1, FGF2, KIT, MYC, PGR
6MP:00053877.2ESR1, KIT, MYC, PCNA, PGR, TLR3
7MP:00053847.2ACTC1, ESR1, FGF2, KIT, MYC, PGR
8MP:00053897.1BMP6, ESR1, FGF2, KIT, MYC, PCNA
9MP:00053696.9ACTC1, ENG, ESR1, FGF2, KIT, MYC
10MP:00053856.8ACTC1, ENG, ESR1, FGF2, KIT, MYC
11MP:00053766.2ACTC1, ENG, ESR1, FGF2, KIT, MYC
12MP:00053976.0ENG, ESR1, FGF2, KIT, MYC, PCNA
13MP:00107685.9ACTC1, ENG, ESR1, FGF2, KIT, MYC

Publications for Juvenile Nasopharyngeal Angiofibroma

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Articles related to Juvenile Nasopharyngeal Angiofibroma:

(show top 50)    (show all 278)
idTitleAuthorsYear
1
Association of alpha-thalassemia, TNF-alpha (-308G>A) and VCAM-1 (c.1238G>C) gene polymorphisms with cerebrovascular disease in a newborn cohort of 411 children with sickle cell anemia. (25175566)
2014
2
A founder mutation in PET100 causes isolated complex IV deficiency in Lebanese individuals with Leigh syndrome. (24462369)
2014
3
Lymphadenectomy in Locally Advanced Cervical Cancer Study (LiLACS): Phase III Clinical Trial Comparing Surgical With Radiologic Staging in Patients With Stages IB2-IVA Cervical Cancer. (23911560)
2014
4
Clinical, radiological, and genetic survey of patients with muscle-eye-brain disease caused by mutations in POMGNT1. (24731844)
2014
5
TRIM38 inhibits TNFI+- and IL-1I^-triggered NF-I_B activation by mediating lysosome-dependent degradation of TAB2/3. (24434549)
2014
6
A case series of chronic necrotizing pulmonary aspergillosis and a new proposal. (23883842)
2013
7
KDM6A point mutations cause Kabuki syndrome. (23076834)
2013
8
Influence of FCGRT gene polymorphisms on pharmacokinetics of therapeutic antibodies. (23751752)
2013
9
Artificial dermis (MatridermAr) followed by skin graft as an option in dermatofibrosarcoma protuberans with complete circumferential and peripheral deep margin assessment. (24102765)
2013
10
Hypothermic endpoint for an intranasal invasive pulmonary aspergillosis mouse model. (24326222)
2013
11
Identification of a TTR gene mutation in a family with hereditary vitreous amyloidosis]. (22311483)
2012
12
Communicating hydrocephalus following surgery and adjuvant radiochemotherapy for glioblastoma. (21905801)
2011
13
Seasonal variation in TP53 R249S-mutated serum DNA with aflatoxin exposure and hepatitis B virus infection. (21768053)
2011
14
Mast cells express IL-17A in rheumatoid arthritis synovium. (20200272)
2010
15
Co-localization of GSTP1 and JNK in transitional cell carcinoma of urinary bladder. (21637416)
2010
16
Neighbourhood alcohol availability and gonorrhea rates: impact of social capital. (19440966)
2009
17
Thrombopoietin and its splicing variants: structure and functions in thrombopoiesis and beyond. (18433726)
2008
18
The CUL7 E3 ubiquitin ligase targets insulin receptor substrate 1 for ubiquitin-dependent degradation. (18498745)
2008
19
Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of the central zinc-binding domain of the human Mcm10 DNA-replication factor. (18540058)
2008
20
Necrotic neuronal cells induce inflammatory Schwann cell activation via TLR2 and TLR3: implication in Wallerian degeneration. (17027917)
2006
21
Anxiety disorder comobidity in Bipolar I Disorder: relationship to depression severity and treatment outcome. (15786484)
2005
22
Stress in the brain: novel cellular mechanisms of injury linked to Alzheimer's disease. (15960984)
2005
23
Generation of silent synapses by acute in vivo expression of CaMKIV and CREB. (15748849)
2005
24
Genotypes and haplotypes of the methyl-CpG-binding domain 2 modify breast cancer risk dependent upon menopausal status. (16168120)
2005
25
Curative resection by superior hepatectomy for advanced hepatoblastoma facilitated by the presence of a large inferior right hepatic vein. (18333062)
2004
26
Endodermal sinus tumor of the parotid gland in a child. (15255038)
2004
27
Oestrogen replacement therapy may improve memory functioning in the absence of APOE epsilon4. (15201477)
2004
28
Lipid-protein interactions in Escherichia coli membranes over-expressing the sugar-H(+) symporter, GalP EPR of spin-labelled lipids. (12659966)
2003
29
Accumulation of cholesterol in the lesions of focal segmental glomerulosclerosis. (15012708)
2003
30
Multivariate analysis of risk factors for development of duodenal ulcer in Helicobacter pylori-infected patients. (12743437)
2003
31
Cathepsins B, H, and L activities in urine of patients with transitional cell carcinoma of the bladder. (11834417)
2002
32
Diagnosis and management of cor triatriatum dexter in a Pyrenean mountain dog and an Akita Inu. (11301744)
2001
33
Retinoblastoma protein complexes with C/EBP proteins and activates C/EBP-mediated transcription. (11596110)
2001
34
Downregulation of an AIM-1 kinase couples with megakaryocytic polyploidization of human hematopoietic cells. (11266445)
2001
35
Inhibition of human alpha-thrombin by a phosphonate tripeptide proceeds via a metastable pentacoordinated phosphorus intermediate. (11493008)
2001
36
Aromatic hydrocarbon receptor interaction with the retinoblastoma protein potentiates repression of E2F-dependent transcription and cell cycle arrest. (10644764)
2000
37
HIV-1 Tat: coping with negative elongation factors. (10448148)
1999
38
A new regulatory domain on the TATA-binding protein. (10581240)
1999
39
p73beta, unlike p53, suppresses growth and induces apoptosis of human papillomavirus E6-expressing cancer cells. (9625796)
1998
40
Which patients should receive an ACE inhibitor after acute myocardial infarction? (9595001)
1998
41
Mutations in the human skeletal muscle chloride channel gene (CLCN1) associated with dominant and recessive myotonia congenita. (8857733)
1996
42
Astrocytosis, beta A4-protein deposition and paired helical filament formation in Alzheimer's disease. (1469442)
1992
43
Human platelet glycoprotein IIIb binds to thrombospondin fragments bearing the C-terminal region, and/or the type I repeats (CSVTCG motif), but not to the N-terminal heparin-binding region. (1376110)
1992
44
Evidence of HLA-linked susceptibility gene(s) in primary congenital glaucoma. (2088635)
1990
45
Sonographic diagnosis of a neoplasm in a bladder diverticulum. (3921722)
1985
46
Combined neutrophil and T-cell deficiency: initial report of a kindred with features of the hyper-IgE syndrome and chronic granulomatous disease. (6979928)
1982
47
Clostridium difficile colitis in a rabbit following antibiotic therapy for pasteurellosis. (7332710)
1981
48
Lactose intolerance--a review. (18727)
1977
49
CALCULOUS BILIARY TRACT DISEASE. (14152330)
1964
50
Gallbladder disease. (14912512)
1952

Variations for Juvenile Nasopharyngeal Angiofibroma

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Expression for genes affiliated with Juvenile Nasopharyngeal Angiofibroma

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Search GEO for disease gene expression data for Juvenile Nasopharyngeal Angiofibroma.

Pathways for genes affiliated with Juvenile Nasopharyngeal Angiofibroma

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Pathways related to Juvenile Nasopharyngeal Angiofibroma according to GeneCards Suite gene sharing:

(show all 21)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.4TLR3, TLR7, TLR9
2
Show member pathways
9.4TLR3, TLR7, TLR9
3
Show member pathways
9.4TLR3, TLR7, TLR9
49.4TLR3, TLR7, TLR9
59.3ENG, ESR1, MYC
69.3FGF2, MYC, VEGFA
7
Show member pathways
9.2FGF2, MYC, VEGFA
89.1BMI1, FGF2, VEGFA
99.1BMP6, FGF2, VEGFA
109.1BMI1, FGF2, MYC
119.0ESR1, FGF2, MYC, VEGFA
129.0KIT, TLR7, TLR9
13
Show member pathways
8.8MYC, PCNA, TLR3, TLR7, TLR9
148.8BMI1, FGF2, MYC, VEGFA
158.8MYC, TLR3, TLR7, TLR9, VEGFA
168.7ESR1, FGF2, MYC, PCNA, VEGFA
178.7ACTC1, FGF2, KIT
188.4FGF2, KIT, MYC, VEGFA
198.4FGF2, KIT, MYC, VEGFA
20
Show member pathways
8.2BMP6, FGF2, TLR3, TLR7, TLR9
218.0BMP6, ENG, FGF2, KIT

GO Terms for genes affiliated with Juvenile Nasopharyngeal Angiofibroma

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Biological processes related to Juvenile Nasopharyngeal Angiofibroma according to GeneCards Suite gene sharing:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of interferon-beta biosynthetic processGO:004535910.5TLR3, TLR9
2positive regulation of interferon-beta productionGO:003272810.4TLR3, TLR9
3positive regulation of mesenchymal cell proliferationGO:000205310.4MYC, VEGFA
4I-kappaB phosphorylationGO:000725210.4TLR3, TLR9
5positive regulation of interleukin-12 productionGO:003273510.4TLR3, TLR9
6positive regulation of toll-like receptor signaling pathwayGO:003412310.3TLR3, TLR9
7cell migration involved in sprouting angiogenesisGO:000204210.3FGF2, VEGFA
8patterning of blood vesselsGO:000156910.3ENG, VEGFA
9artery morphogenesisGO:004884410.2ENG, VEGFA
10positive regulation of blood vessel endothelial cell migrationGO:004353610.2FGF2, VEGFA
11microglial cell activationGO:000177410.1TLR3, TLR7
12positive regulation of NF-kappaB import into nucleusGO:004234610.1TLR3, TLR7, TLR9
13positive regulation of interleukin-8 productionGO:00327579.9TLR3, TLR7, TLR9
14toll-like receptor signaling pathwayGO:00022249.8TLR3, TLR7, TLR9
15positive regulation of protein phosphorylationGO:00019349.6FGF2, TLR3, VEGFA
16positive regulation of phosphatidylinositol 3-kinase activityGO:00435529.4FGF2, KIT
17positive regulation of angiogenesisGO:00457669.4ENG, FGF2, VEGFA
18positive regulation of phospholipase C activityGO:00108639.3ESR1, FGF2, KIT
19negative regulation of transcription from RNA polymerase II promoterGO:00001229.1BMI1, BMP6, ESR1, VEGFA
20angiogenesisGO:00015259.1ENG, FGF2, VEGFA
21inflammatory responseGO:00069548.7BMP6, KIT, TLR3, TLR7
22innate immune responseGO:00450877.9FGF2, KIT, TLR3, TLR7, TLR9
23positive regulation of transcription from RNA polymerase II promoterGO:00459447.8BMP6, ENG, ESR1, FGF2, MYC, VEGFA
24positive regulation of gene expressionGO:00106287.8FGF2, KIT, TLR3, TLR9, VEGFA

Sources for Juvenile Nasopharyngeal Angiofibroma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet