MCID: JVN052
MIFTS: 18

Juvenile-Onset Parkinson Disease

Categories: Rare diseases, Neuronal diseases, Mental diseases, Genetic diseases, Metabolic diseases

Aliases & Classifications for Juvenile-Onset Parkinson Disease

MalaCards integrated aliases for Juvenile-Onset Parkinson Disease:

Name: Juvenile-Onset Parkinson Disease 12 14

Classifications:



External Ids:

Disease Ontology 12 DOID:0060893

Summaries for Juvenile-Onset Parkinson Disease

MalaCards based summary : Juvenile-Onset Parkinson Disease is related to kufor-rakeb syndrome and parkinson disease 19a, juvenile-onset. An important gene associated with Juvenile-Onset Parkinson Disease is ATP13A2 (ATPase 13A2).

Related Diseases for Juvenile-Onset Parkinson Disease

Diseases in the Parkinson Disease, Late-Onset family:

Parkinson Disease 1, Autosomal Dominant Parkinson Disease 15, Autosomal Recessive Early-Onset
Parkinson Disease 12 Parkinson Disease 2, Autosomal Recessive Juvenile
Parkinson Disease 3, Autosomal Dominant Parkinson Disease 4, Autosomal Dominant
Parkinson Disease 6, Autosomal Recessive Early-Onset Parkinson Disease 7, Autosomal Recessive Early-Onset
Parkinson Disease 10 Parkinson Disease 8, Autosomal Dominant
Parkinson Disease 11, Autosomal Dominant Parkinson Disease 13, Autosomal Dominant
Parkinson Disease 14, Autosomal Recessive Parkinson Disease 16
Parkinson Disease 5, Autosomal Dominant Parkinson Disease 17
Parkinson Disease 18, Autosomal Dominant Parkinson Disease 19a, Juvenile-Onset
Parkinson Disease 20, Early-Onset Parkinson Disease 21
Parkinson Disease 22, Autosomal Dominant Parkinson Disease 23, Autosomal Recessive Early-Onset
Juvenile-Onset Parkinson Disease Early-Onset Parkinson Disease
Parkinson Disease Type 9 Hereditary Late-Onset Parkinson Disease

Diseases related to Juvenile-Onset Parkinson Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 14)
# Related Disease Score Top Affiliating Genes
1 kufor-rakeb syndrome 29.2 ATP13A2 ATP13A5 ATP1B4 FBXO7 PANK2 PLA2G6
2 parkinson disease 19a, juvenile-onset 11.4
3 parkinson disease, late-onset 11.1
4 neurodegeneration with brain iron accumulation 5 9.7 PANK2 PLA2G6
5 neurodegeneration with brain iron accumulation 4 9.7 PANK2 PLA2G6
6 neurodegeneration with brain iron accumulation 3 9.6 PANK2 PLA2G6
7 neurodegeneration with brain iron accumulation 1 9.6 PANK2 PLA2G6
8 neuroaxonal dystrophy 9.5 PANK2 PLA2G6
9 neurodegeneration with brain iron accumulation 9.4 ATP13A2 PANK2 PLA2G6
10 aceruloplasminemia 9.4 ATP13A2 PANK2 PLA2G6
11 neurodegeneration with brain iron accumulation 6 9.4 PANK2 PLA2G6
12 neurodegeneration with brain iron accumulation 2b 9.3 FBXO7 PANK2 PLA2G6
13 neurodegeneration with brain iron accumulation 2a 9.0 ATP13A2 FBXO7 PANK2 PLA2G6
14 parkinson disease 15, autosomal recessive early-onset 9.0 ATP13A2 FBXO7 PANK2 PLA2G6

Graphical network of the top 20 diseases related to Juvenile-Onset Parkinson Disease:



Diseases related to Juvenile-Onset Parkinson Disease

Symptoms & Phenotypes for Juvenile-Onset Parkinson Disease

Drugs & Therapeutics for Juvenile-Onset Parkinson Disease

Search Clinical Trials , NIH Clinical Center for Juvenile-Onset Parkinson Disease

Genetic Tests for Juvenile-Onset Parkinson Disease

Anatomical Context for Juvenile-Onset Parkinson Disease

Publications for Juvenile-Onset Parkinson Disease

Variations for Juvenile-Onset Parkinson Disease

Expression for Juvenile-Onset Parkinson Disease

Search GEO for disease gene expression data for Juvenile-Onset Parkinson Disease.

Pathways for Juvenile-Onset Parkinson Disease

GO Terms for Juvenile-Onset Parkinson Disease

Biological processes related to Juvenile-Onset Parkinson Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium ion transmembrane transport GO:0070588 9.32 ATP13A2 ATP13A5
2 cellular calcium ion homeostasis GO:0006874 9.26 ATP13A2 ATP13A5
3 cation transport GO:0006812 9.16 ATP13A2 ATP13A5
4 negative regulation of neuron death GO:1901215 8.96 ATP13A2 FBXO7
5 ATP hydrolysis coupled cation transmembrane transport GO:0099132 8.62 ATP13A2 ATP13A5

Molecular functions related to Juvenile-Onset Parkinson Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity GO:0016787 9.46 ATP13A2 ATP13A5 DNAJC6 PLA2G6
2 calcium-transporting ATPase activity GO:0005388 8.96 ATP13A2 ATP13A5
3 cation-transporting ATPase activity GO:0019829 8.62 ATP13A2 ATP13A5

Sources for Juvenile-Onset Parkinson Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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