MCID: JVN009
MIFTS: 28

Juvenile Pilocytic Astrocytoma malady

Summaries for Juvenile Pilocytic Astrocytoma

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33MalaCards
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MalaCards: Juvenile Pilocytic Astrocytoma is related to pilocytic astrocytoma and astrocytoma. An important gene associated with Juvenile Pilocytic Astrocytoma is TNC (tenascin C), and among its related pathways are Cell adhesion ECM remodeling and Selected targets of Oct-3/4. The compounds silver and cytarabine have been mentioned in the context of this disorder. Affiliated tissues include brain, cerebellum and pineal.

Aliases & Classifications for Juvenile Pilocytic Astrocytoma

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 35MeSH, 40NCIt
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Aliases & Descriptions:

juvenile pilocytic astrocytoma 8 10 45 61


External Ids:

Disease Ontology8 DOID:6811
MeSH35 D001254
NCIt40 C27081

Related Diseases for Juvenile Pilocytic Astrocytoma

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Juvenile Pilocytic Astrocytoma:



Diseases related to juvenile pilocytic astrocytoma

Clinical Features for Juvenile Pilocytic Astrocytoma

Drugs & Therapeutics for Juvenile Pilocytic Astrocytoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Juvenile Pilocytic Astrocytoma

Drug clinical trials:

Search ClinicalTrials for Juvenile Pilocytic Astrocytoma

Search NIH Clinical Center for Juvenile Pilocytic Astrocytoma

Search CenterWatch for Juvenile Pilocytic Astrocytoma

Genetic Tests for Juvenile Pilocytic Astrocytoma

Anatomical Context for Juvenile Pilocytic Astrocytoma

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33MalaCards
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MalaCards organs/tissues related to Juvenile Pilocytic Astrocytoma:

33
Brain, Cerebellum, Pineal, Pituitary

Animal Models for Juvenile Pilocytic Astrocytoma or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Juvenile Pilocytic Astrocytoma

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51PubMed
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Articles related to Juvenile Pilocytic Astrocytoma:

(show all 44)
idTitleAuthorsYear
1
An unbalanced translocation involving loss of 10q26.2 and gain of 11q25 in a pedigree with autism spectrum disorder and cerebellar juvenile pilocytic astrocytoma. (23495067)
2013
2
Juvenile pilocytic astrocytoma in association with arteriovenous malformation. (22681727)
2012
3
Secondary glioblastoma multiforme in a child with disseminated juvenile pilocytic astrocytoma. (23227384)
2012
4
Retrocochlear hearing loss in infants: a case study of juvenile pilocytic astrocytoma. (22642312)
2012
5
Transformation of juvenile pilocytic astrocytoma to anaplastic pilocytic astrocytoma in patients with neurofibromatosis type I. (21572348)
2011
6
Picture of the month--quiz case. Lisch nodules, ectropion uveae, and optic pathway glioma (juvenile pilocytic astrocytoma) due to neurofibromatosis type 1. (20439802)
2010
7
Medulloblastoma and juvenile pilocytic astrocytoma presenting as synchronous primary brain tumors in a child: case report. (20121362)
2010
8
Long-term functional outcome of surgical treatment of juvenile pilocytic astrocytoma of the cerebellum in children. (19418058)
2009
9
Role of diffusion tensor imaging in resection of thalamic juvenile pilocytic astrocytoma. (19951034)
2009
10
Duplication of 7q34 is specific to juvenile pilocytic astrocytomas and a hallmark of cerebellar and optic pathway tumours. (19603027)
2009
11
Supratentorial juvenile pilocytic astrocytoma in a young adult with Silver-Russell syndrome. (18661310)
2008
12
Steroid responsive fluctuating sensorineural hearing loss due to juvenile pilocytic astrocytoma involving the cerebellopontine angle. (18255162)
2008
13
Excision of juvenile pilocytic astrocytoma of the midbrain after radiotherapy. (16902345)
2006
14
Gefitinib is effective against juvenile pilocytic astrocytoma in vitro. (16206208)
2006
15
Expression analysis of juvenile pilocytic astrocytomas by oligonucleotide microarray reveals two potential subgroups. (15665281)
2005
16
Juvenile pilocytic astrocytoma 'pilomyxoid variant' with spinal metastases. (15261239)
2004
17
Juvenile pilocytic astrocytoma of the brainstem in children. (16206964)
2004
18
Oligodendroglioma and juvenile pilocytic astrocytoma presenting as synchronous primary brain tumors. Case report with histological and molecular differentiation of the tumors and review of the literature. (15070126)
2004
19
Juvenile pilocytic astrocytoma presenting with subarachnoid hemorrhage. Case report and review of the literature. (15287467)
2004
20
Juvenile pilocytic astrocytoma. (12880155)
2003
21
Successful high-dose chemotherapy for widespread neuroaxis dissemination of an optico-hypothalamic juvenile pilocytic astrocytoma in an infant: a case report. (12777080)
2003
22
Case report: Hemispheric juvenile pilocytic astrocytoma with extreme exophytic growth. (11384146)
2001
23
Spontaneous cerebellar hemorrhage due to a juvenile pilocytic astrocytoma: case report and review of the literature. (11423772)
2001
24
Concurrent acute lymphoblastic leukemia and juvenile pilocytic astrocytoma in a pediatric patient. (11037859)
2000
25
High frequency of TP53 mutations in juvenile pilocytic astrocytomas indicates role of TP53 in the development of these tumors. (10416986)
1999
26
Multicentric juvenile pilocytic astrocytoma occurring primarily in the trigone of the lateral ventricle. (10502010)
1999
27
Hypothalamic juvenile pilocytic astrocytoma presenting with intracerebral hemorrhage. (9872037)
1998
28
The use of early postoperative MR in detecting residual juvenile cerebellar pilocytic astrocytoma. (9432173)
1998
29
Tracer transport and metabolism in a patient with juvenile pilocytic astrocytoma. A PET study. (9524106)
1998
30
Juvenile pilocytic astrocytoma masquerading as amblyopia. (9152078)
1997
31
Diencephalic syndrome and disseminated juvenile pilocytic astrocytomas of the hypothalamic-optic chiasm region. (9210720)
1997
32
Normal evoked otoacoustic emissions with a profound hearing loss due to a juvenile pilocytic astrocytoma. (8841714)
1996
33
Deletion of chromosome arm 17p DNA sequences in pediatric high-grade and juvenile pilocytic astrocytomas. (7536455)
1995
34
Leptomeningeal dissemination of juvenile pilocytic astrocytoma: case report. (8165503)
1994
35
Treatment options and prognosis for multicentric juvenile pilocytic astrocytoma. (8207524)
1994
36
High frequency of p53 protein accumulation without p53 gene mutation in human juvenile pilocytic, low grade and anaplastic astrocytomas. (8108140)
1994
37
Radiation therapy for juvenile pilocytic astrocytoma of the pituitary stalk. Case report. (1607955)
1992
38
Metastatic juvenile pilocytic astrocytoma. Case report. (1941128)
1991
39
Treatment results of juvenile pilocytic astrocytoma. (3392563)
1988
40
Juvenile pilocytic astrocytoma of the optic nerve diagnosed by fine needle aspiration biopsy. (3376707)
1988
41
Juvenile pilocytic astrocytoma of the cerebrum in adults. A distinctive neoplasm with favorable prognosis. (4020465)
1985
42
Juvenile pilocytic astrocytoma of the pineal region: report of a case. (7104961)
1982
43
Isolated trochlear nerve palsy secondary to a juvenile pilocytic astrocytoma. (6226694)
1982
44
Pilocytic (juvenile) astrocytoma of the optic nerve. The influence of biopsy. (662271)
1978

Genetic Variations for Juvenile Pilocytic Astrocytoma

Expression for genes affiliated with Juvenile Pilocytic Astrocytoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Juvenile Pilocytic Astrocytoma

Search GEO for disease gene expression data for Juvenile Pilocytic Astrocytoma.

Pathways for genes affiliated with Juvenile Pilocytic Astrocytoma

Sources:
12EMD Millipore, 38NCBI BioSystems Database
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Pathways related to Juvenile Pilocytic Astrocytoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Cell adhesion ECM remodeling
Hide members
9.5TNC, MBP
29.4TP53, TNC
39.3TP53, MBP
4
G-protein signaling Ras family GTPases in kinase cascades (scheme)
Hide members
9.3TP53, MBP

Compounds for genes affiliated with Juvenile Pilocytic Astrocytoma

Sources:
45Novoseek, 50PharmGKB, 11DrugBank
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Compounds related to Juvenile Pilocytic Astrocytoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1silver459.4TNC, MBP
2cytarabine45 50 1111.3TP53, MBP
3mitomycin c459.0TP53, MBP
4paraffin459.0TP53, TNC, MBP
5cycloheximide458.9TP53, TNC, MBP
6h2o2458.9MBP, TNC, TP53

GO Terms for genes affiliated with Juvenile Pilocytic Astrocytoma

Sources:
16Gene Ontology
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Biological processes related to Juvenile Pilocytic Astrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1central nervous system developmentGO:0074179.3TP53, MBP

Molecular functions related to Juvenile Pilocytic Astrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:0020209.3TP53, MBP

Products for genes affiliated with Juvenile Pilocytic Astrocytoma

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Sources for Juvenile Pilocytic Astrocytoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet