MCID: JVN009
MIFTS: 30

Juvenile Pilocytic Astrocytoma malady

Rare diseases, Neuronal diseases, Cancer diseases categories

Aliases & Classifications for Juvenile Pilocytic Astrocytoma

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 38NCIt, 33MeSH
See all sources

Juvenile Pilocytic Astrocytoma, Aliases & Descriptions:

Name: Juvenile Pilocytic Astrocytoma 9 11 43 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Neuronal diseases


External Ids:

Disease Ontology9 DOID:6811
NCIt38 C27081
MeSH33 D001254

Summaries for Juvenile Pilocytic Astrocytoma

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MalaCards based summary: Juvenile Pilocytic Astrocytoma is related to astrocytoma and glioblastoma multiforme. An important gene associated with Juvenile Pilocytic Astrocytoma is TNC (tenascin C), and among its related pathways are Cell adhesion ECM remodeling and Selected targets of Oct 3 4. The compounds silver and formaldehyde have been mentioned in the context of this disorder. Affiliated tissues include brain, cerebellum and endothelial, and related mouse phenotypes are homeostasis/metabolism and nervous system.

Related Diseases for Juvenile Pilocytic Astrocytoma

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Graphical network of the top 20 diseases related to Juvenile Pilocytic Astrocytoma:



Diseases related to juvenile pilocytic astrocytoma

Symptoms for Juvenile Pilocytic Astrocytoma

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Drugs & Therapeutics for Juvenile Pilocytic Astrocytoma

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Drug clinical trials:

Search ClinicalTrials for Juvenile Pilocytic Astrocytoma

Search NIH Clinical Center for Juvenile Pilocytic Astrocytoma

Genetic Tests for Juvenile Pilocytic Astrocytoma

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Anatomical Context for Juvenile Pilocytic Astrocytoma

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MalaCards organs/tissues related to Juvenile Pilocytic Astrocytoma:

31
Brain, Cerebellum, Endothelial, Pineal, Pituitary

Animal Models for Juvenile Pilocytic Astrocytoma or affiliated genes

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MGI Mouse Phenotypes related to Juvenile Pilocytic Astrocytoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.2MBP, TP53, TNC, ZBTB20
2MP:00036317.9MBP, TP53, TNC, ZBTB20

Publications for Juvenile Pilocytic Astrocytoma

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Articles related to Juvenile Pilocytic Astrocytoma:

(show all 43)
idTitleAuthorsYear
1
A case of central precocious puberty due to concomitant hypothalamic hamartoma and juvenile pilocytic astrocytoma. (25241615)
2014
2
Intracranial organizing hematoma with papillary endothelial hyperplasia features after resection and involved field radiotherapy for cerebellar juvenile pilocytic astrocytoma. (24456989)
2014
3
An unbalanced translocation involving loss of 10q26.2 and gain of 11q25 in a pedigree with autism spectrum disorder and cerebellar juvenile pilocytic astrocytoma. (23495067)
2013
4
Juvenile pilocytic astrocytoma in association with arteriovenous malformation. (22681727)
2012
5
Secondary glioblastoma multiforme in a child with disseminated juvenile pilocytic astrocytoma. (23227384)
2012
6
Retrocochlear hearing loss in infants: a case study of juvenile pilocytic astrocytoma. (22642312)
2012
7
Transformation of juvenile pilocytic astrocytoma to anaplastic pilocytic astrocytoma in patients with neurofibromatosis type I. (21572348)
2011
8
Picture of the month--quiz case. Lisch nodules, ectropion uveae, and optic pathway glioma (juvenile pilocytic astrocytoma) due to neurofibromatosis type 1. (20439802)
2010
9
Medulloblastoma and juvenile pilocytic astrocytoma presenting as synchronous primary brain tumors in a child: case report. (20121362)
2010
10
Long-term functional outcome of surgical treatment of juvenile pilocytic astrocytoma of the cerebellum in children. (19418058)
2009
11
Role of diffusion tensor imaging in resection of thalamic juvenile pilocytic astrocytoma. (19951034)
2009
12
Duplication of 7q34 is specific to juvenile pilocytic astrocytomas and a hallmark of cerebellar and optic pathway tumours. (19603027)
2009
13
Supratentorial juvenile pilocytic astrocytoma in a young adult with Silver-Russell syndrome. (18661310)
2008
14
Steroid responsive fluctuating sensorineural hearing loss due to juvenile pilocytic astrocytoma involving the cerebellopontine angle. (18255162)
2008
15
Excision of juvenile pilocytic astrocytoma of the midbrain after radiotherapy. (16902345)
2006
16
Gefitinib is effective against juvenile pilocytic astrocytoma in vitro. (16206208)
2006
17
Expression analysis of juvenile pilocytic astrocytomas by oligonucleotide microarray reveals two potential subgroups. (15665281)
2005
18
Juvenile pilocytic astrocytoma 'pilomyxoid variant' with spinal metastases. (15261239)
2004
19
Juvenile pilocytic astrocytoma of the brainstem in children. (16206964)
2004
20
Oligodendroglioma and juvenile pilocytic astrocytoma presenting as synchronous primary brain tumors. Case report with histological and molecular differentiation of the tumors and review of the literature. (15070126)
2004
21
Juvenile pilocytic astrocytoma presenting with subarachnoid hemorrhage. Case report and review of the literature. (15287467)
2004
22
Juvenile pilocytic astrocytoma. (12880155)
2003
23
Successful high-dose chemotherapy for widespread neuroaxis dissemination of an optico-hypothalamic juvenile pilocytic astrocytoma in an infant: a case report. (12777080)
2003
24
Case report: Hemispheric juvenile pilocytic astrocytoma with extreme exophytic growth. (11384146)
2001
25
Spontaneous cerebellar hemorrhage due to a juvenile pilocytic astrocytoma: case report and review of the literature. (11423772)
2001
26
Concurrent acute lymphoblastic leukemia and juvenile pilocytic astrocytoma in a pediatric patient. (11037859)
2000
27
High frequency of TP53 mutations in juvenile pilocytic astrocytomas indicates role of TP53 in the development of these tumors. (10416986)
1999
28
Multicentric juvenile pilocytic astrocytoma occurring primarily in the trigone of the lateral ventricle. (10502010)
1999
29
Hypothalamic juvenile pilocytic astrocytoma presenting with intracerebral hemorrhage. (9872037)
1998
30
Tracer transport and metabolism in a patient with juvenile pilocytic astrocytoma. A PET study. (9524106)
1998
31
Juvenile pilocytic astrocytoma masquerading as amblyopia. (9152078)
1997
32
Diencephalic syndrome and disseminated juvenile pilocytic astrocytomas of the hypothalamic-optic chiasm region. (9210720)
1997
33
Normal evoked otoacoustic emissions with a profound hearing loss due to a juvenile pilocytic astrocytoma. (8841714)
1996
34
Deletion of chromosome arm 17p DNA sequences in pediatric high-grade and juvenile pilocytic astrocytomas. (7536455)
1995
35
Leptomeningeal dissemination of juvenile pilocytic astrocytoma: case report. (8165503)
1994
36
Treatment options and prognosis for multicentric juvenile pilocytic astrocytoma. (8207524)
1994
37
Radiation therapy for juvenile pilocytic astrocytoma of the pituitary stalk. Case report. (1607955)
1992
38
Metastatic juvenile pilocytic astrocytoma. Case report. (1941128)
1991
39
Treatment results of juvenile pilocytic astrocytoma. (3392563)
1988
40
Juvenile pilocytic astrocytoma of the optic nerve diagnosed by fine needle aspiration biopsy. (3376707)
1988
41
Juvenile pilocytic astrocytoma of the cerebrum in adults. A distinctive neoplasm with favorable prognosis. (4020465)
1985
42
Juvenile pilocytic astrocytoma of the pineal region: report of a case. (7104961)
1982
43
Isolated trochlear nerve palsy secondary to a juvenile pilocytic astrocytoma. (6226694)
1982

Variations for Juvenile Pilocytic Astrocytoma

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Expression for genes affiliated with Juvenile Pilocytic Astrocytoma

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Search GEO for disease gene expression data for Juvenile Pilocytic Astrocytoma.

Pathways for genes affiliated with Juvenile Pilocytic Astrocytoma

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Pathways related to Juvenile Pilocytic Astrocytoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Metalloproteases in connective tissue degradation
9.5MBP, TNC
29.1MBP, TP53
3
Show member pathways
MAPK Cascade36
Immune response Oncostatin M signaling via MAPK in human cells58
Oncostatin M Signaling Pathway36
9.1MBP, TP53

Compounds for genes affiliated with Juvenile Pilocytic Astrocytoma

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Sources:
43Novoseek, 24HMDB, 49PharmGKB, 12DrugBank, 28IUPHAR
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Compounds related to Juvenile Pilocytic Astrocytoma according to GeneCards Suite gene sharing:

(show all 13)
idCompoundScoreTop Affiliating Genes
1silver439.7MBP, TNC
2formaldehyde43 2410.6MBP, TNC
3mitomycin c439.3MBP, TP53
4cytarabine43 49 1211.3MBP, TP53
5gaba439.2MBP, TNC
6cyclophosphamide43 49 1211.1TP53, MBP
7n acetylcysteine439.1MBP, TP53
8phosphatidylserine43 28 1211.0MBP, TP53
9paraffin438.9MBP, TP53, TNC
10cycloheximide438.9MBP, TP53, TNC
11h2o2438.9TNC, TP53, MBP
12estrogen438.8TNC, TP53, MBP
13retinoic acid43 249.8MBP, TP53, TNC

GO Terms for genes affiliated with Juvenile Pilocytic Astrocytoma

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Biological processes related to Juvenile Pilocytic Astrocytoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1central nervous system developmentGO:00074179.1MBP, TP53

Molecular functions related to Juvenile Pilocytic Astrocytoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:00020209.1MBP, TP53

Products for genes affiliated with Juvenile Pilocytic Astrocytoma

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Sources for Juvenile Pilocytic Astrocytoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet