MCID: JVN009
MIFTS: 47

Juvenile Pilocytic Astrocytoma

Categories: Rare diseases, Neuronal diseases, Cancer diseases

Aliases & Classifications for Juvenile Pilocytic Astrocytoma

MalaCards integrated aliases for Juvenile Pilocytic Astrocytoma:

Name: Juvenile Pilocytic Astrocytoma 12 51 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:6811
MeSH 41 D001254
NCIt 46 C27081
UMLS 69 C0280783

Summaries for Juvenile Pilocytic Astrocytoma

MalaCards based summary : Juvenile Pilocytic Astrocytoma is related to pilocytic astrocytoma and astrocytoma, and has symptoms including headache An important gene associated with Juvenile Pilocytic Astrocytoma is TIMP3 (TIMP Metallopeptidase Inhibitor 3), and among its related pathways/superpathways are MAPK signaling pathway and Neuroscience. The drugs Donepezil and Fentanyl have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and bone, and related phenotypes are behavior/neurological and cellular

Related Diseases for Juvenile Pilocytic Astrocytoma

Diseases in the Pilocytic Astrocytoma family:

Juvenile Pilocytic Astrocytoma

Diseases related to Juvenile Pilocytic Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 125)
# Related Disease Score Top Affiliating Genes
1 pilocytic astrocytoma 33.1 CDKN2A FGF2 GFAP NF1 TIMP3
2 astrocytoma 31.1 CDKN2A GFAP NF1 TP53
3 medulloblastoma 29.6 ENO2 GFAP TIMP3 TP53
4 glioblastoma multiforme 29.4 CD44 CDKN2A GFAP TP53
5 oligodendroglioma 29.1 CDKN2A ENO2 GFAP MBP TP53
6 childhood pilocytic astrocytoma 10.5 NF1 NTM
7 brain stem astrocytic neoplasm 10.4 CDKN2A TP53
8 frontal convexity meningioma 10.4 GFAP TP53
9 splenic diffuse red pulp small b-cell lymphoma 10.4 MAP2K1 TP53
10 squamous cell carcinoma of the oropharynx 10.4 CDKN2A TP53
11 cornea cancer 10.4 FGF2 GFAP
12 cerebral convexity meningioma 10.4 GFAP TP53
13 protoplasmic astrocytoma 10.4 GFAP TP53
14 spitz nevus 10.4 CDKN2A TP53
15 cellular ependymoma 10.3 GFAP TP53
16 keratinizing squamous cell carcinoma 10.3 CDKN2A TP53
17 bladder squamous cell carcinoma 10.3 CDKN2A FGF2 TP53
18 squamous cell carcinoma of the larynx 10.3 CDKN2A TP53
19 vulvar dystrophy 10.3 CDKN2A MBP
20 actinic keratosis 10.3 CDKN2A TNC TP53
21 endometrial adenocarcinoma 10.3 CDKN2A FGF2 TP53
22 skin melanoma 10.3 CDKN2A FGF2 TP53
23 cellular schwannoma 10.3 CDKN2A NF1 TP53
24 gliofibroma 10.2 GFAP NF1 TP53
25 bartholin's gland benign neoplasm 10.2 CDKN2A TP53
26 duodenal somatostatinoma 10.2 ENO2 NF1
27 epithelioid malignant peripheral nerve sheath tumor 10.2 ENO2 NF1
28 intracranial cysts 10.2 ENO2 GFAP
29 li-fraumeni syndrome 10.2 CDKN2A NF1 TP53
30 primitive neuroectodermal tumor of the cervix uteri 10.2 ENO2 GFAP
31 atypical neurofibroma 10.2 CDKN2A GFAP NF1
32 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.2
33 melanotic medulloblastoma 10.2 ENO2 GFAP
34 connective tissue cancer 10.2 ENO2 FGF2 TP53
35 atypical follicular adenoma 10.2 ENO2 TP53
36 malignant peripheral nerve sheath tumor 10.2 CDKN2A NF1 TP53
37 necrotizing sialometaplasia 10.2 CDKN2A GFAP TP53
38 melanoma, cutaneous malignant 1 10.1 CDKN2A MAP2K1 TP53
39 finger agnosia 10.1 ENO2 MBP
40 grade iii astrocytoma 10.1 CDKN2A GFAP TP53
41 organ system benign neoplasm 10.1 ENO2 NF1 TP53
42 peripheral nervous system neoplasm 10.1 ENO2 NF1 TP53
43 neonatal hypoxic and ischemic brain injury 10.1 ENO2 MBP
44 cerebellum cancer 10.1 ENO2 TP53
45 cerebellar medulloblastoma 10.1 ENO2 GFAP
46 neurofibromatosis, type iv, of riccardi 10.1
47 neuroma 10.1 ENO2 FGF2 GFAP
48 plexiform schwannoma 10.1 ENO2 GFAP NF1
49 small cell neuroendocrine carcinoma 10.1 CDKN2A ENO2 TP53
50 meningeal melanomatosis 10.1 CDKN2A ENO2 TP53

Graphical network of the top 20 diseases related to Juvenile Pilocytic Astrocytoma:



Diseases related to Juvenile Pilocytic Astrocytoma

Symptoms & Phenotypes for Juvenile Pilocytic Astrocytoma

UMLS symptoms related to Juvenile Pilocytic Astrocytoma:


headache

MGI Mouse Phenotypes related to Juvenile Pilocytic Astrocytoma:

43 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.33 CD44 CDKN2A ENO2 FGF2 GFAP INSR
2 cellular MP:0005384 10.3 DDX3X ENO2 FGF2 GFAP INSR MAP2K1
3 cardiovascular system MP:0005385 10.28 CD44 CDKN2A DDX3X FGF2 GFAP INSR
4 growth/size/body region MP:0005378 10.27 INSR MAP2K1 MBP NF1 TIMP3 TP53
5 homeostasis/metabolism MP:0005376 10.27 CD44 CDKN2A DDX3X FGF2 GFAP INSR
6 mortality/aging MP:0010768 10.18 CD44 CDKN2A DDX3X FGF2 GFAP INSR
7 nervous system MP:0003631 10.07 CD44 CDKN2A DDX3X ENO2 FGF2 GFAP
8 digestive/alimentary MP:0005381 10.05 CD44 CDKN2A GFAP INSR MAP2K1 NF1
9 muscle MP:0005369 10.02 NF1 TIMP3 TP53 CD44 CDKN2A DDX3X
10 liver/biliary system MP:0005370 9.98 CD44 CDKN2A INSR NF1 TIMP3 TP53
11 hearing/vestibular/ear MP:0005377 9.95 FGF2 MAP2K1 MBP NF1 TNC TP53
12 neoplasm MP:0002006 9.8 MAP2K1 NF1 TP53 CD44 CDKN2A FGF2
13 normal MP:0002873 9.76 CD44 DDX3X GFAP MAP2K1 MBP NF1
14 respiratory system MP:0005388 9.5 CD44 CDKN2A ENO2 INSR NF1 TIMP3
15 vision/eye MP:0005391 9.32 CD44 CDKN2A FGF2 GFAP MAP2K1 MBP

Drugs & Therapeutics for Juvenile Pilocytic Astrocytoma

Drugs for Juvenile Pilocytic Astrocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 152)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Donepezil Approved Phase 3,Phase 2 120014-06-4 3152
2
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
3
Vincristine Approved, Investigational Phase 2, Phase 3,Phase 1 2068-78-2, 57-22-7 5978
4
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
5
Procarbazine Approved, Investigational Phase 2, Phase 3 671-16-9 4915
6
Lomustine Approved, Investigational Phase 2, Phase 3 13010-47-4 3950
7
Histamine Approved, Investigational Phase 3 51-45-6, 75614-87-8 774
8
Cyproheptadine Approved Phase 3 129-03-3 2913
9
Methylphenidate Approved, Investigational Phase 3 20748-11-2, 113-45-1 4158
10 Pancreatic Polypeptide Investigational Phase 3,Phase 1 59763-91-6
11 Alkylating Agents Phase 2, Phase 3,Phase 1
12 Dermatologic Agents Phase 3,Phase 2,Phase 1
13 Analgesics Phase 3
14 Central Nervous System Depressants Phase 3
15 Adjuvants, Anesthesia Phase 3
16 Central Nervous System Stimulants Phase 3,Phase 2
17 Cholinergic Agents Phase 3,Phase 2
18 Narcotics Phase 3
19 Cholinesterase Inhibitors Phase 3,Phase 2
20 Gastrointestinal Agents Phase 3,Phase 1
21 Neurotransmitter Agents Phase 3,Phase 2
22 Analgesics, Opioid Phase 3
23 Nootropic Agents Phase 3,Phase 2
24 Anesthetics Phase 3
25 Anesthetics, General Phase 3
26 Anesthetics, Intravenous Phase 3
27 Peripheral Nervous System Agents Phase 3
28 Antimitotic Agents Phase 2, Phase 3,Phase 1
29 Liver Extracts Phase 3,Phase 2,Phase 1
30 Antineoplastic Agents, Phytogenic Phase 2, Phase 3,Phase 1
31 Dopamine Agents Phase 3
32
Histamine Phosphate Phase 3 51-74-1 65513
33
Serotonin Phase 3 50-67-9 5202
34 Serotonin Agents Phase 3
35 Serotonin Antagonists Phase 3
36 Neurotransmitter Uptake Inhibitors Phase 3
37 Histamine Antagonists Phase 3
38 Histamine H1 Antagonists Phase 3
39 Dexmethylphenidate Hydrochloride Phase 3
40 Anti-Allergic Agents Phase 3
41 Dopamine Uptake Inhibitors Phase 3
42 Antipruritics Phase 3
43 Cola Nutraceutical Phase 3,Phase 1
44
Dacarbazine Approved, Investigational Phase 2,Phase 1 4342-03-4 5351166
45
Temozolomide Approved, Investigational Phase 2,Phase 1 85622-93-1 5394
46
Trioxsalen Approved Phase 2,Phase 1 3902-71-4 5585
47
Doxorubicin Approved, Investigational Phase 2,Phase 1 23214-92-8 31703
48
Cisplatin Approved Phase 2,Phase 1 15663-27-1 2767 441203 84093
49
Topotecan Approved, Investigational Phase 2 119413-54-6, 123948-87-8 60700
50
Irinotecan Approved, Investigational Phase 1, Phase 2 97682-44-5, 100286-90-6 60838

Interventional clinical trials:

(show top 50) (show all 65)

# Name Status NCT ID Phase Drugs
1 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
2 Donepezil in Treating Patients Who Have Undergone Radiation Therapy for Brain Tumors Completed NCT00369785 Phase 3 donepezil hydrochloride;Placebo
3 Observation or Radiation Therapy With or Without Combination Chemotherapy in Treating Patients With Low-Grade Glioma Active, not recruiting NCT00003375 Phase 2, Phase 3 lomustine;procarbazine hydrochloride;vincristine sulfate
4 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
5 Methylphenidate to Improve Quality of Life in Patients Undergoing Radiation Therapy for Brain Tumors Terminated NCT00031798 Phase 3 methylphenidate hydrochloride
6 Temozolomide in Treating Patients With Low-Grade Glioma Completed NCT00313729 Phase 2 temozolomide
7 Erlotinib and Temsirolimus in Treating Patients With Recurrent Malignant Glioma Completed NCT00112736 Phase 1, Phase 2 erlotinib;temsirolimus
8 Carmustine in Treating Adults With Recurrent Supratentorial Low-Grade Glioma Completed NCT00003467 Phase 2 carmustine;polifeprosan 20 with carmustine implant
9 Armodafinil in Treating Fatigue Caused By Radiation Therapy in Patients With Primary Brain Tumors Completed NCT01032200 Phase 2 Armodafinil
10 Temozolomide in Treating Patients With Progressive Low-Grade Glioma Completed NCT00003466 Phase 2 temozolomide
11 Tamoxifen, Carboplatin, and Topotecan in Treating Patients With CNS Metastases or Recurrent Brain or Spinal Cord Tumors Completed NCT00541138 Phase 2 carboplatin;tamoxifen citrate;topotecan hydrochloride
12 Temozolomide in Treating Patients With Recurrent Glioblastoma Multiforme or Other Malignant Glioma Completed NCT00498927 Phase 2 temozolomide
13 Magnetic Resonance Imaging and Magnetic Resonance Spectroscopic Imaging in Evaluating Patients Who Are Undergoing Treatment for Gliomas Completed NCT00274755 Phase 2 chemotherapy
14 Imatinib Mesylate in Treating Patients With Gliomas Completed NCT00039364 Phase 2 imatinib mesylate
15 Gefitinib in Treating Patients With Recurrent or Progressive CNS Tumors Completed NCT00025675 Phase 2 gefitinib
16 Phase II Studies Of Donepezil And Ginkgo Biloba In Irradiated Brain Tumor Completed NCT00070161 Phase 2 donepezil hydrochloride
17 Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Primary or Metastatic Brain Cancers Completed NCT00002752 Phase 1, Phase 2
18 Imatinib Mesylate in Treating Patients With Recurrent Malignant Glioma or Meningioma Completed NCT00010049 Phase 1, Phase 2 imatinib mesylate
19 Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Primary or Metastatic Brain Tumors Completed NCT00003461 Phase 1, Phase 2
20 Combination Chemotherapy and Tamoxifen in Treating Patients With Solid Tumors Completed NCT00002608 Phase 2 cisplatin;doxorubicin hydrochloride;tamoxifen citrate
21 Phase II Pegylated Interferon Recruiting NCT02343224 Phase 2 Pegylated interferon alpha-2b
22 A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas Recruiting NCT01837862 Phase 1, Phase 2 Mebendazole;Vincristine;Carboplatin;Temozolomide;Bevacizumab;Irinotecan
23 Selumetinib in Treating Young Patients With Recurrent or Refractory Low Grade Glioma Recruiting NCT01089101 Phase 1, Phase 2 Selumetinib
24 Low-Dose or High-Dose Lenalidomide in Treating Younger Patients With Recurrent, Refractory, or Progressive Pilocytic Astrocytoma or Optic Pathway Glioma Active, not recruiting NCT01553149 Phase 2 Lenalidomide
25 Photodynamic Therapy (PDT) For Recurrent High Grade Gliomas Active, not recruiting NCT01966809 Phase 2 Photofrin photodynamic therapy.
26 Bevacizumab in Recurrent Grade II and III Glioma Active, not recruiting NCT01164189 Phase 2 Temozolomide
27 Everolimus, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Active, not recruiting NCT00553150 Phase 1, Phase 2 everolimus;temozolomide
28 Iodine I 131 Monoclonal Antibody 3F8 in Treating Patients With Central Nervous System Cancer or Leptomeningeal Cancer Active, not recruiting NCT00445965 Phase 2
29 Crizotinib in Treating Young Patients With Relapsed or Refractory Solid Tumors or Anaplastic Large Cell Lymphoma Active, not recruiting NCT00939770 Phase 1, Phase 2 crizotinib
30 Functional Magnetic Resonance Imaging and 1H-Nuclear Magnetic Resonance Spectroscopic Imaging in Treating Patients With Newly Diagnosed Brain Tumors Withdrawn NCT00005083 Phase 2
31 Photodynamic Therapy With Porfimer Sodium in Treating Patients With Refractory Brain Tumors Unknown status NCT00002647 Phase 1 verteporfin
32 Lonafarnib and Temozolomide in Treating Patients With Recurrent Primary Supratentorial Gliomas Unknown status NCT00083096 Phase 1 lonafarnib;temozolomide
33 RO4929097, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Malignant Glioma Completed NCT01119599 Phase 1 Gamma-Secretase Inhibitor RO4929097;Temozolomide
34 Erlotinib in Treating Patients With Solid Tumors and Liver or Kidney Dysfunction Completed NCT00030498 Phase 1 erlotinib hydrochloride
35 Cellular Adoptive Immunotherapy Using Genetically Modified T-Lymphocytes in Treating Patients With Recurrent or Refractory High-Grade Malignant Glioma Completed NCT00730613 Phase 1
36 Sodium Stibogluconate and IFNa-2b Followed By CDDP, VLB and DTIC Treating Pts.With Advanced Melanoma or Other Cancers Completed NCT00498979 Phase 1 cisplatin;sodium stibogluconate;dacarbazine;vinblastine
37 Bortezomib and Temozolomide in Treating Patients With Brain Tumors or Other Solid Tumors That Have Not Responded to Treatment Completed NCT00544284 Phase 1 bortezomib;temozolomide
38 Erlotinib and Sirolimus in Treating Patients With Recurrent Malignant Glioma Completed NCT00509431 Phase 1 Erlotinib + Sirolimus
39 Yttrium Y 90 SMT 487 in Treating Patients With Refractory or Recurrent Cancer Completed NCT00006368 Phase 1
40 BCX-1777 in Treating Patients With Refractory Cancer Completed NCT00073944 Phase 1 forodesine hydrochloride
41 Calcitriol Plus Carboplatin in Treating Patients With Advanced Solid Tumors Completed NCT00008086 Phase 1 carboplatin
42 Radiolabeled Monoclonal Antibody Therapy After Radiation Therapy in Treating Patients With Primary Brain Tumors Completed NCT00003484 Phase 1 carmustine;irinotecan hydrochloride
43 Thalidomide and Docetaxel in Treating Patients With Advanced Cancer Completed NCT00049296 Phase 1 docetaxel;thalidomide
44 MS-275 in Treating Patients With Advanced Solid Tumors or Lymphoma Completed NCT00020579 Phase 1 entinostat
45 Carboxyamidotriazole and Paclitaxel in Treating Patients With Advanced Solid Tumors or Refractory Lymphomas Completed NCT00019019 Phase 1 carboxyamidotriazole;paclitaxel
46 Monoclonal Antibody Therapy in Treating Patients With Leptomeningeal Cancer Completed NCT00003022 Phase 1
47 Imetelstat Sodium in Treating Young Patients With Refractory or Recurrent Solid Tumors or Lymphoma Completed NCT01273090 Phase 1 imetelstat sodium
48 Cognitive Biomarkers in Pediatric Brain Tumor Patients Recruiting NCT02914067 Phase 1
49 Using MRI-Guided Laser Heat Ablation to Induce Disruption of the Peritumoral Blood Brain Barrier to Enhance Delivery and Efficacy of Treatment of Pediatric Brain Tumors Recruiting NCT02372409 Phase 1 Doxorubicin;Etoposide
50 Photodynamic Therapy (PDT) for Recurrent Pediatric Brain Tumors Recruiting NCT01682746 Phase 1 Photofrin (porfimer sodium) & photodynamic therapy.

Search NIH Clinical Center for Juvenile Pilocytic Astrocytoma

Genetic Tests for Juvenile Pilocytic Astrocytoma

Anatomical Context for Juvenile Pilocytic Astrocytoma

MalaCards organs/tissues related to Juvenile Pilocytic Astrocytoma:

38
Brain, Liver, Bone, Kidney, Spinal Cord, Pituitary, Pineal

Publications for Juvenile Pilocytic Astrocytoma

Articles related to Juvenile Pilocytic Astrocytoma:

(show all 50)
# Title Authors Year
1
Long-term outcomes of primarily metastatic juvenile pilocytic astrocytoma in children. ( 29125440 )
2018
2
Resection of a Pediatric Thalamic Juvenile Pilocytic Astrocytoma with Whole Brain Tractography. ( 29234572 )
2017
3
Spontaneous aneurysmal subarachnoid haemorrhage in a child with multiply recurrent posterior fossa juvenile pilocytic astrocytoma. ( 27927709 )
2016
4
Using urinary bFGF and TIMP3 levels to predict the presence of juvenile pilocytic astrocytoma and establish a distinct biomarker signature. ( 27314542 )
2016
5
Hodgkin's lymphoma in an adolescent previously treated with surgical resection of third ventricular juvenile pilocytic astrocytoma. ( 26113587 )
2015
6
Preoperative Presentation of a Variant of Cerebellar Mutism Syndrome in a Young Boy With Juvenile Pilocytic Astrocytoma. ( 26145481 )
2015
7
Peduncular Hallucinosis as First Presentation of Juvenile Pilocytic Astrocytoma. ( 26548431 )
2015
8
A case of central precocious puberty due to concomitant hypothalamic hamartoma and juvenile pilocytic astrocytoma. ( 25241615 )
2014
9
Intracranial organizing hematoma with papillary endothelial hyperplasia features after resection and involved field radiotherapy for cerebellar juvenile pilocytic astrocytoma. ( 24456989 )
2014
10
An unbalanced translocation involving loss of 10q26.2 and gain of 11q25 in a pedigree with autism spectrum disorder and cerebellar juvenile pilocytic astrocytoma. ( 23495067 )
2013
11
Retrocochlear hearing loss in infants: a case study of juvenile pilocytic astrocytoma. ( 22642312 )
2012
12
Juvenile pilocytic astrocytoma in association with arteriovenous malformation. ( 22681727 )
2012
13
Secondary glioblastoma multiforme in a child with disseminated juvenile pilocytic astrocytoma. ( 23227384 )
2012
14
Transformation of juvenile pilocytic astrocytoma to anaplastic pilocytic astrocytoma in patients with neurofibromatosis type I. ( 21572348 )
2011
15
Picture of the month--quiz case. Lisch nodules, ectropion uveae, and optic pathway glioma (juvenile pilocytic astrocytoma) due to neurofibromatosis type 1. ( 20439802 )
2010
16
Medulloblastoma and juvenile pilocytic astrocytoma presenting as synchronous primary brain tumors in a child: case report. ( 20121362 )
2010
17
Role of diffusion tensor imaging in resection of thalamic juvenile pilocytic astrocytoma. ( 19951034 )
2009
18
Long-term functional outcome of surgical treatment of juvenile pilocytic astrocytoma of the cerebellum in children. ( 19418058 )
2009
19
Duplication of 7q34 is specific to juvenile pilocytic astrocytomas and a hallmark of cerebellar and optic pathway tumours. ( 19603027 )
2009
20
Supratentorial juvenile pilocytic astrocytoma in a young adult with Silver-Russell syndrome. ( 18661310 )
2008
21
Steroid responsive fluctuating sensorineural hearing loss due to juvenile pilocytic astrocytoma involving the cerebellopontine angle. ( 18255162 )
2008
22
Gefitinib is effective against juvenile pilocytic astrocytoma in vitro. ( 16206208 )
2006
23
Excision of juvenile pilocytic astrocytoma of the midbrain after radiotherapy. ( 16902345 )
2006
24
Expression analysis of juvenile pilocytic astrocytomas by oligonucleotide microarray reveals two potential subgroups. ( 15665281 )
2005
25
Juvenile pilocytic astrocytoma 'pilomyxoid variant' with spinal metastases. ( 15261239 )
2004
26
Juvenile pilocytic astrocytoma of the brainstem in children. ( 16206964 )
2004
27
Juvenile pilocytic astrocytoma presenting with subarachnoid hemorrhage. Case report and review of the literature. ( 15287467 )
2004
28
Oligodendroglioma and juvenile pilocytic astrocytoma presenting as synchronous primary brain tumors. Case report with histological and molecular differentiation of the tumors and review of the literature. ( 15070126 )
2004
29
Juvenile pilocytic astrocytoma. ( 12880155 )
2003
30
Successful high-dose chemotherapy for widespread neuroaxis dissemination of an optico-hypothalamic juvenile pilocytic astrocytoma in an infant: a case report. ( 12777080 )
2003
31
Spontaneous cerebellar hemorrhage due to a juvenile pilocytic astrocytoma: case report and review of the literature. ( 11423772 )
2001
32
Case report: Hemispheric juvenile pilocytic astrocytoma with extreme exophytic growth. ( 11384146 )
2001
33
Concurrent acute lymphoblastic leukemia and juvenile pilocytic astrocytoma in a pediatric patient. ( 11037859 )
2000
34
Multicentric juvenile pilocytic astrocytoma occurring primarily in the trigone of the lateral ventricle. ( 10502010 )
1999
35
High frequency of TP53 mutations in juvenile pilocytic astrocytomas indicates role of TP53 in the development of these tumors. ( 10416986 )
1999
36
Hypothalamic juvenile pilocytic astrocytoma presenting with intracerebral hemorrhage. ( 9872037 )
1998
37
Tracer transport and metabolism in a patient with juvenile pilocytic astrocytoma. A PET study. ( 9524106 )
1998
38
Diencephalic syndrome and disseminated juvenile pilocytic astrocytomas of the hypothalamic-optic chiasm region. ( 9210720 )
1997
39
Juvenile pilocytic astrocytoma masquerading as amblyopia. ( 9152078 )
1997
40
Normal evoked otoacoustic emissions with a profound hearing loss due to a juvenile pilocytic astrocytoma. ( 8841714 )
1996
41
Deletion of chromosome arm 17p DNA sequences in pediatric high-grade and juvenile pilocytic astrocytomas. ( 7536455 )
1995
42
Leptomeningeal dissemination of juvenile pilocytic astrocytoma: case report. ( 8165503 )
1994
43
Treatment options and prognosis for multicentric juvenile pilocytic astrocytoma. ( 8207524 )
1994
44
Radiation therapy for juvenile pilocytic astrocytoma of the pituitary stalk. Case report. ( 1607955 )
1992
45
Metastatic juvenile pilocytic astrocytoma. Case report. ( 1941128 )
1991
46
Juvenile pilocytic astrocytoma of the optic nerve diagnosed by fine needle aspiration biopsy. ( 3376707 )
1988
47
Treatment results of juvenile pilocytic astrocytoma. ( 3392563 )
1988
48
Juvenile pilocytic astrocytoma of the cerebrum in adults. A distinctive neoplasm with favorable prognosis. ( 4020465 )
1985
49
Juvenile pilocytic astrocytoma of the pineal region: report of a case. ( 7104961 )
1982
50
Isolated trochlear nerve palsy secondary to a juvenile pilocytic astrocytoma. ( 6226694 )
1982

Variations for Juvenile Pilocytic Astrocytoma

Expression for Juvenile Pilocytic Astrocytoma

Search GEO for disease gene expression data for Juvenile Pilocytic Astrocytoma.

Pathways for Juvenile Pilocytic Astrocytoma

GO Terms for Juvenile Pilocytic Astrocytoma

Biological processes related to Juvenile Pilocytic Astrocytoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.88 CDKN2A FGF2 INSR MAP2K1 TP53
2 positive regulation of gene expression GO:0010628 9.72 CDKN2A DDX3X MAP2K1 TNC TP53
3 MAPK cascade GO:0000165 9.71 FGF2 MAP2K1 MBP NF1
4 activation of MAPK activity GO:0000187 9.67 FGF2 INSR MAP2K1
5 hyaluronan catabolic process GO:0030214 9.46 CD44 FGF2
6 wound healing GO:0042060 9.46 FGF2 NF1 TNC TP53
7 replicative senescence GO:0090399 9.43 CDKN2A TP53
8 Bergmann glial cell differentiation GO:0060020 9.37 GFAP MAP2K1
9 extracellular matrix organization GO:0030198 9.35 CD44 FGF2 GFAP NF1 TNC
10 neuron recognition GO:0008038 9.26 NTM OPCML
11 Ras protein signal transduction GO:0007265 8.92 CDKN2A FGF2 NF1 TP53

Molecular functions related to Juvenile Pilocytic Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.53 CD276 CD44 CDKN2A DDX3X ENO2 FGF2
2 transcription factor binding GO:0008134 9.46 CDKN2A DDX3X MLX TP53
3 protease binding GO:0002020 9.13 MBP TIMP3 TP53

Sources for Juvenile Pilocytic Astrocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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