MCID: JVN009
MIFTS: 35

Juvenile Pilocytic Astrocytoma malady

Cancer diseases, Rare diseases, Neuronal diseases categories

Summaries for Juvenile Pilocytic Astrocytoma

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34MalaCards
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MalaCards: Juvenile Pilocytic Astrocytoma is related to astrocytoma and glioblastoma multiforme. An important gene associated with Juvenile Pilocytic Astrocytoma is TNC (tenascin C), and among its related pathways are Cell adhesion ECM remodeling and Selected targets of Oct 3 4. The compounds silver and formaldehyde have been mentioned in the context of this disorder. Affiliated tissues include brain, pineal and pituitary, and related mouse phenotypes are homeostasis/metabolism and nervous system.

Aliases & Classifications for Juvenile Pilocytic Astrocytoma

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 41NCIt, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

juvenile pilocytic astrocytoma 9 11 46 63


External Ids:

Disease Ontology9 DOID:6811
NCIt41 C27081
MeSH36 D001254

Related Diseases for Juvenile Pilocytic Astrocytoma

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Pilocytic Astrocytoma family:

juvenile pilocytic astrocytoma

Diseases related to Juvenile Pilocytic Astrocytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 29)
idRelated DiseaseScoreTop Affiliating Genes
1astrocytoma31.6MBP, TP53, TNC
2glioblastoma multiforme30.5TP53, TNC
3oligodendroglioma30.4MBP, TP53
4pilocytic astrocytoma11.1
5neurofibromatosis10.4
6sensorineural hearing loss10.3
7trigonitis10.3
8arteriovenous malformation10.3
9silver-russell syndrome10.3
10amblyopia10.3
11autism spectrum disorder10.3
12ectropion10.3
13leukemia10.3
14lymphoblastic leukemia10.3
15medulloblastoma10.3
16diencephalic syndrome10.3
17optic pathway glioma10.3
18meningioma10.1TNC
19liposarcoma10.0TNC, TP53
20anaplastic astrocytoma10.0TP53, TNC
21oral cancer10.0TNC, TP53
22thyroid cancer10.0TP53, TNC
23bladder carcinoma10.0TNC, TP53
24neurofibroma10.0TNC, MBP
25endometrial carcinoma10.0TP53, TNC
26brain cancer10.0TNC, TP53
27malignant glioma9.9TNC, TP53, MBP
28burkitt's lymphoma9.9MBP, TNC, TP53
29melanoma9.9TP53, TNC, MBP

Graphical network of the top 20 diseases related to Juvenile Pilocytic Astrocytoma:



Diseases related to juvenile pilocytic astrocytoma

Symptoms for Juvenile Pilocytic Astrocytoma

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Drugs & Therapeutics for Juvenile Pilocytic Astrocytoma

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Juvenile Pilocytic Astrocytoma

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Anatomical Context for Juvenile Pilocytic Astrocytoma

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34MalaCards
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MalaCards organs/tissues related to Juvenile Pilocytic Astrocytoma:

34
Brain, Pineal, Pituitary, Cerebellum

Animal Models for Juvenile Pilocytic Astrocytoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Juvenile Pilocytic Astrocytoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.2MBP, TP53, TNC, ZBTB20
2MP:00036317.9MBP, TP53, TNC, ZBTB20

Publications for Juvenile Pilocytic Astrocytoma

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53PubMed
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Articles related to Juvenile Pilocytic Astrocytoma:

(show all 41)
idTitleAuthorsYear
1
An unbalanced translocation involving loss of 10q26.2 and gain of 11q25 in a pedigree with autism spectrum disorder and cerebellar juvenile pilocytic astrocytoma. (23495067)
2013
2
Juvenile pilocytic astrocytoma in association with arteriovenous malformation. (22681727)
2012
3
Secondary glioblastoma multiforme in a child with disseminated juvenile pilocytic astrocytoma. (23227384)
2012
4
Retrocochlear hearing loss in infants: a case study of juvenile pilocytic astrocytoma. (22642312)
2012
5
Transformation of juvenile pilocytic astrocytoma to anaplastic pilocytic astrocytoma in patients with neurofibromatosis type I. (21572348)
2011
6
Picture of the month--quiz case. Lisch nodules, ectropion uveae, and optic pathway glioma (juvenile pilocytic astrocytoma) due to neurofibromatosis type 1. (20439802)
2010
7
Medulloblastoma and juvenile pilocytic astrocytoma presenting as synchronous primary brain tumors in a child: case report. (20121362)
2010
8
Long-term functional outcome of surgical treatment of juvenile pilocytic astrocytoma of the cerebellum in children. (19418058)
2009
9
Role of diffusion tensor imaging in resection of thalamic juvenile pilocytic astrocytoma. (19951034)
2009
10
Duplication of 7q34 is specific to juvenile pilocytic astrocytomas and a hallmark of cerebellar and optic pathway tumours. (19603027)
2009
11
Supratentorial juvenile pilocytic astrocytoma in a young adult with Silver-Russell syndrome. (18661310)
2008
12
Steroid responsive fluctuating sensorineural hearing loss due to juvenile pilocytic astrocytoma involving the cerebellopontine angle. (18255162)
2008
13
Excision of juvenile pilocytic astrocytoma of the midbrain after radiotherapy. (16902345)
2006
14
Gefitinib is effective against juvenile pilocytic astrocytoma in vitro. (16206208)
2006
15
Expression analysis of juvenile pilocytic astrocytomas by oligonucleotide microarray reveals two potential subgroups. (15665281)
2005
16
Juvenile pilocytic astrocytoma 'pilomyxoid variant' with spinal metastases. (15261239)
2004
17
Juvenile pilocytic astrocytoma of the brainstem in children. (16206964)
2004
18
Oligodendroglioma and juvenile pilocytic astrocytoma presenting as synchronous primary brain tumors. Case report with histological and molecular differentiation of the tumors and review of the literature. (15070126)
2004
19
Juvenile pilocytic astrocytoma presenting with subarachnoid hemorrhage. Case report and review of the literature. (15287467)
2004
20
Juvenile pilocytic astrocytoma. (12880155)
2003
21
Successful high-dose chemotherapy for widespread neuroaxis dissemination of an optico-hypothalamic juvenile pilocytic astrocytoma in an infant: a case report. (12777080)
2003
22
Case report: Hemispheric juvenile pilocytic astrocytoma with extreme exophytic growth. (11384146)
2001
23
Spontaneous cerebellar hemorrhage due to a juvenile pilocytic astrocytoma: case report and review of the literature. (11423772)
2001
24
Concurrent acute lymphoblastic leukemia and juvenile pilocytic astrocytoma in a pediatric patient. (11037859)
2000
25
High frequency of TP53 mutations in juvenile pilocytic astrocytomas indicates role of TP53 in the development of these tumors. (10416986)
1999
26
Multicentric juvenile pilocytic astrocytoma occurring primarily in the trigone of the lateral ventricle. (10502010)
1999
27
Hypothalamic juvenile pilocytic astrocytoma presenting with intracerebral hemorrhage. (9872037)
1998
28
Tracer transport and metabolism in a patient with juvenile pilocytic astrocytoma. A PET study. (9524106)
1998
29
Juvenile pilocytic astrocytoma masquerading as amblyopia. (9152078)
1997
30
Diencephalic syndrome and disseminated juvenile pilocytic astrocytomas of the hypothalamic-optic chiasm region. (9210720)
1997
31
Normal evoked otoacoustic emissions with a profound hearing loss due to a juvenile pilocytic astrocytoma. (8841714)
1996
32
Deletion of chromosome arm 17p DNA sequences in pediatric high-grade and juvenile pilocytic astrocytomas. (7536455)
1995
33
Leptomeningeal dissemination of juvenile pilocytic astrocytoma: case report. (8165503)
1994
34
Treatment options and prognosis for multicentric juvenile pilocytic astrocytoma. (8207524)
1994
35
Radiation therapy for juvenile pilocytic astrocytoma of the pituitary stalk. Case report. (1607955)
1992
36
Metastatic juvenile pilocytic astrocytoma. Case report. (1941128)
1991
37
Treatment results of juvenile pilocytic astrocytoma. (3392563)
1988
38
Juvenile pilocytic astrocytoma of the optic nerve diagnosed by fine needle aspiration biopsy. (3376707)
1988
39
Juvenile pilocytic astrocytoma of the cerebrum in adults. A distinctive neoplasm with favorable prognosis. (4020465)
1985
40
Juvenile pilocytic astrocytoma of the pineal region: report of a case. (7104961)
1982
41
Isolated trochlear nerve palsy secondary to a juvenile pilocytic astrocytoma. (6226694)
1982

Variations for Juvenile Pilocytic Astrocytoma

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Expression for genes affiliated with Juvenile Pilocytic Astrocytoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Juvenile Pilocytic Astrocytoma

Search GEO for disease gene expression data for Juvenile Pilocytic Astrocytoma.

Pathways for genes affiliated with Juvenile Pilocytic Astrocytoma

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51PathCards, 61Thomson Reuters, 13EMD Millipore, 39NCBI BioSystems Database, 56Reactome
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Pathways related to Juvenile Pilocytic Astrocytoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5MBP, TNC
29.2TP53, TNC
39.1MBP, TP53
4
Show member pathways
MAPK Cascade39
Immune response Oncostatin M signaling via MAPK in human cells61
Oncostatin M Signaling Pathway39
9.1MBP, TP53

Compounds for genes affiliated with Juvenile Pilocytic Astrocytoma

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46Novoseek, 25HMDB, 52PharmGKB, 12DrugBank, 30IUPHAR
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Compounds related to Juvenile Pilocytic Astrocytoma according to GeneCards/GeneDecks:

(show all 13)
idCompoundScoreTop Affiliating Genes
1silver469.7MBP, TNC
2formaldehyde46 2510.6MBP, TNC
3mitomycin c469.3MBP, TP53
4cytarabine46 52 1211.3TP53, MBP
5gaba469.2TNC, MBP
6cyclophosphamide46 52 1211.1MBP, TP53
7n acetylcysteine469.1TP53, MBP
8phosphatidylserine46 30 1211.0MBP, TP53
9paraffin468.9TP53, TNC, MBP
10cycloheximide468.9TNC, TP53, MBP
11h2o2468.9TP53, TNC, MBP
12estrogen468.8MBP, TP53, TNC
13retinoic acid46 259.8MBP, TNC, TP53

GO Terms for genes affiliated with Juvenile Pilocytic Astrocytoma

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17Gene Ontology
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Biological processes related to Juvenile Pilocytic Astrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1central nervous system developmentGO:0074179.1MBP, TP53

Molecular functions related to Juvenile Pilocytic Astrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:0020209.1MBP, TP53

Products for genes affiliated with Juvenile Pilocytic Astrocytoma

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Sources for Juvenile Pilocytic Astrocytoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet