MCID: JVN009
MIFTS: 36

Juvenile Pilocytic Astrocytoma malady

Cancer diseases, Rare diseases, Neuronal diseases categories
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Summaries for Juvenile Pilocytic Astrocytoma

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MalaCards based summary: Juvenile Pilocytic Astrocytoma is related to astrocytoma and glioblastoma multiforme. An important gene associated with Juvenile Pilocytic Astrocytoma is TNC (tenascin C), and among its related pathways are Cell adhesion ECM remodeling and Selected targets of Oct 3 4. The compounds silver and formaldehyde have been mentioned in the context of this disorder. Affiliated tissues include brain, cerebellum and endothelial, and related mouse phenotypes are homeostasis/metabolism and nervous system.

Aliases & Classifications for Juvenile Pilocytic Astrocytoma

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 39NCIt, 34MeSH
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Juvenile Pilocytic Astrocytoma, Aliases & Descriptions:

Name: Juvenile Pilocytic Astrocytoma 8 10 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Neuronal diseases


External Ids:

Disease Ontology8 DOID:6811
NCIt39 C27081
MeSH34 D001254

Related Diseases for Juvenile Pilocytic Astrocytoma

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Graphical network of the top 20 diseases related to Juvenile Pilocytic Astrocytoma:



Diseases related to juvenile pilocytic astrocytoma

Symptoms for Juvenile Pilocytic Astrocytoma

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Drugs & Therapeutics for Juvenile Pilocytic Astrocytoma

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Drug clinical trials:

Search ClinicalTrials for Juvenile Pilocytic Astrocytoma

Search NIH Clinical Center for Juvenile Pilocytic Astrocytoma

Genetic Tests for Juvenile Pilocytic Astrocytoma

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Anatomical Context for Juvenile Pilocytic Astrocytoma

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MalaCards organs/tissues related to Juvenile Pilocytic Astrocytoma:

32
Brain, Cerebellum, Endothelial, Pineal, Pituitary

Animal Models for Juvenile Pilocytic Astrocytoma or affiliated genes

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MGI Mouse Phenotypes related to Juvenile Pilocytic Astrocytoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.2MBP, TP53, TNC, ZBTB20
2MP:00036317.9MBP, TP53, TNC, ZBTB20

Publications for Juvenile Pilocytic Astrocytoma

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Articles related to Juvenile Pilocytic Astrocytoma:

(show all 42)
idTitleAuthorsYear
1
A case of central precocious puberty due to concomitant hypothalamic hamartoma and juvenile pilocytic astrocytoma. (25241615)
2014
2
Intracranial organizing hematoma with papillary endothelial hyperplasia features after resection and involved field radiotherapy for cerebellar juvenile pilocytic astrocytoma. (24456989)
2014
3
An unbalanced translocation involving loss of 10q26.2 and gain of 11q25 in a pedigree with autism spectrum disorder and cerebellar juvenile pilocytic astrocytoma. (23495067)
2013
4
Juvenile pilocytic astrocytoma in association with arteriovenous malformation. (22681727)
2012
5
Secondary glioblastoma multiforme in a child with disseminated juvenile pilocytic astrocytoma. (23227384)
2012
6
Retrocochlear hearing loss in infants: a case study of juvenile pilocytic astrocytoma. (22642312)
2012
7
Transformation of juvenile pilocytic astrocytoma to anaplastic pilocytic astrocytoma in patients with neurofibromatosis type I. (21572348)
2011
8
Picture of the month--quiz case. Lisch nodules, ectropion uveae, and optic pathway glioma (juvenile pilocytic astrocytoma) due to neurofibromatosis type 1. (20439802)
2010
9
Medulloblastoma and juvenile pilocytic astrocytoma presenting as synchronous primary brain tumors in a child: case report. (20121362)
2010
10
Long-term functional outcome of surgical treatment of juvenile pilocytic astrocytoma of the cerebellum in children. (19418058)
2009
11
Role of diffusion tensor imaging in resection of thalamic juvenile pilocytic astrocytoma. (19951034)
2009
12
Duplication of 7q34 is specific to juvenile pilocytic astrocytomas and a hallmark of cerebellar and optic pathway tumours. (19603027)
2009
13
Supratentorial juvenile pilocytic astrocytoma in a young adult with Silver-Russell syndrome. (18661310)
2008
14
Steroid responsive fluctuating sensorineural hearing loss due to juvenile pilocytic astrocytoma involving the cerebellopontine angle. (18255162)
2008
15
Excision of juvenile pilocytic astrocytoma of the midbrain after radiotherapy. (16902345)
2006
16
Gefitinib is effective against juvenile pilocytic astrocytoma in vitro. (16206208)
2006
17
Expression analysis of juvenile pilocytic astrocytomas by oligonucleotide microarray reveals two potential subgroups. (15665281)
2005
18
Juvenile pilocytic astrocytoma 'pilomyxoid variant' with spinal metastases. (15261239)
2004
19
Juvenile pilocytic astrocytoma of the brainstem in children. (16206964)
2004
20
Oligodendroglioma and juvenile pilocytic astrocytoma presenting as synchronous primary brain tumors. Case report with histological and molecular differentiation of the tumors and review of the literature. (15070126)
2004
21
Juvenile pilocytic astrocytoma presenting with subarachnoid hemorrhage. Case report and review of the literature. (15287467)
2004
22
Juvenile pilocytic astrocytoma. (12880155)
2003
23
Case report: Hemispheric juvenile pilocytic astrocytoma with extreme exophytic growth. (11384146)
2001
24
Spontaneous cerebellar hemorrhage due to a juvenile pilocytic astrocytoma: case report and review of the literature. (11423772)
2001
25
Concurrent acute lymphoblastic leukemia and juvenile pilocytic astrocytoma in a pediatric patient. (11037859)
2000
26
High frequency of TP53 mutations in juvenile pilocytic astrocytomas indicates role of TP53 in the development of these tumors. (10416986)
1999
27
Multicentric juvenile pilocytic astrocytoma occurring primarily in the trigone of the lateral ventricle. (10502010)
1999
28
Hypothalamic juvenile pilocytic astrocytoma presenting with intracerebral hemorrhage. (9872037)
1998
29
Tracer transport and metabolism in a patient with juvenile pilocytic astrocytoma. A PET study. (9524106)
1998
30
Juvenile pilocytic astrocytoma masquerading as amblyopia. (9152078)
1997
31
Diencephalic syndrome and disseminated juvenile pilocytic astrocytomas of the hypothalamic-optic chiasm region. (9210720)
1997
32
Normal evoked otoacoustic emissions with a profound hearing loss due to a juvenile pilocytic astrocytoma. (8841714)
1996
33
Deletion of chromosome arm 17p DNA sequences in pediatric high-grade and juvenile pilocytic astrocytomas. (7536455)
1995
34
Leptomeningeal dissemination of juvenile pilocytic astrocytoma: case report. (8165503)
1994
35
Treatment options and prognosis for multicentric juvenile pilocytic astrocytoma. (8207524)
1994
36
Radiation therapy for juvenile pilocytic astrocytoma of the pituitary stalk. Case report. (1607955)
1992
37
Metastatic juvenile pilocytic astrocytoma. Case report. (1941128)
1991
38
Treatment results of juvenile pilocytic astrocytoma. (3392563)
1988
39
Juvenile pilocytic astrocytoma of the optic nerve diagnosed by fine needle aspiration biopsy. (3376707)
1988
40
Juvenile pilocytic astrocytoma of the cerebrum in adults. A distinctive neoplasm with favorable prognosis. (4020465)
1985
41
Juvenile pilocytic astrocytoma of the pineal region: report of a case. (7104961)
1982
42
Isolated trochlear nerve palsy secondary to a juvenile pilocytic astrocytoma. (6226694)
1982

Variations for Juvenile Pilocytic Astrocytoma

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Expression for genes affiliated with Juvenile Pilocytic Astrocytoma

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Expression patterns in normal tissues for genes affiliated with Juvenile Pilocytic Astrocytoma

Search GEO for disease gene expression data for Juvenile Pilocytic Astrocytoma.

Pathways for genes affiliated with Juvenile Pilocytic Astrocytoma

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Pathways related to Juvenile Pilocytic Astrocytoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5MBP, TNC
29.2TP53, TNC
39.1MBP, TP53
4
Show member pathways
MAPK Cascade37
Immune response Oncostatin M signaling via MAPK in human cells60
Oncostatin M Signaling Pathway37
9.1MBP, TP53

Compounds for genes affiliated with Juvenile Pilocytic Astrocytoma

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Sources:
44Novoseek, 24HMDB, 50PharmGKB, 11DrugBank, 28IUPHAR
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Compounds related to Juvenile Pilocytic Astrocytoma according to GeneCards/GeneDecks:

(show all 13)
idCompoundScoreTop Affiliating Genes
1silver449.7MBP, TNC
2formaldehyde44 2410.6MBP, TNC
3mitomycin c449.3MBP, TP53
4cytarabine44 50 1111.3MBP, TP53
5gaba449.2MBP, TNC
6cyclophosphamide44 50 1111.1TP53, MBP
7n acetylcysteine449.1MBP, TP53
8phosphatidylserine44 28 1111.0MBP, TP53
9paraffin448.9MBP, TP53, TNC
10cycloheximide448.9MBP, TP53, TNC
11h2o2448.9TNC, TP53, MBP
12estrogen448.8TNC, TP53, MBP
13retinoic acid44 249.8MBP, TP53, TNC

GO Terms for genes affiliated with Juvenile Pilocytic Astrocytoma

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Biological processes related to Juvenile Pilocytic Astrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1central nervous system developmentGO:0074179.1MBP, TP53

Molecular functions related to Juvenile Pilocytic Astrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:0020209.1MBP, TP53

Products for genes affiliated with Juvenile Pilocytic Astrocytoma

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Sources for Juvenile Pilocytic Astrocytoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet