MCID: JVN025
MIFTS: 15

Juvenile Primary Osteoporosis

Categories: Bone diseases, Genetic diseases

Aliases & Classifications for Juvenile Primary Osteoporosis

MalaCards integrated aliases for Juvenile Primary Osteoporosis:

Name: Juvenile Primary Osteoporosis 25 69
Childhood-Onset Primary Osteoporosis 25
Idiopathic Juvenile Osteoporosis 25
Juvenile Osteoporosis 69

Classifications:



Summaries for Juvenile Primary Osteoporosis

Genetics Home Reference : 25 Juvenile primary osteoporosis is a skeletal disorder characterized by thinning of the bones (osteoporosis) that begins in childhood. Osteoporosis is caused by a shortage of calcium and other minerals in bones (decreased bone mineral density), which makes the bones brittle and prone to fracture. Affected individuals often have multiple fractures in the long bones of the arms and legs, especially in the regions where new bone forms (metaphyses). They also have fractures in the bones that form the spine (vertebrae), which can cause collapse of the affected vertebrae (compressed vertebrae). Multiple fractures can cause bone pain and lead to movement problems.

MalaCards based summary : Juvenile Primary Osteoporosis, also known as childhood-onset primary osteoporosis, is related to idiopathic juvenile osteoporosis and osteoporosis. The drugs Alendronate and Pamidronate have been mentioned in the context of this disorder. Affiliated tissues include bone.

Related Diseases for Juvenile Primary Osteoporosis

Diseases in the Osteoporosis family:

Osteoporosis, Early-Onset Autosomal Dominant Juvenile Primary Osteoporosis

Diseases related to Juvenile Primary Osteoporosis via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 idiopathic juvenile osteoporosis 12.5
2 osteoporosis 10.5
3 osteogenesis imperfecta 9.9
4 lymphoma 9.7
5 scoliosis 9.7
6 ehlers-danlos syndrome 9.7
7 back pain 9.7

Graphical network of the top 20 diseases related to Juvenile Primary Osteoporosis:



Diseases related to Juvenile Primary Osteoporosis

Symptoms & Phenotypes for Juvenile Primary Osteoporosis

Drugs & Therapeutics for Juvenile Primary Osteoporosis

Drugs for Juvenile Primary Osteoporosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Alendronate Approved Phase 4,Phase 2,Phase 3 121268-17-5, 66376-36-1 2088
2
Pamidronate Approved Phase 4 40391-99-9 4674
3 Bone Density Conservation Agents Phase 4,Phase 2,Phase 3,Phase 1
4 Diphosphonates Phase 4
5
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
6
Norepinephrine Approved Phase 3 51-41-2 439260
7 glucocorticoids Phase 2, Phase 3,Phase 1
8 Analgesics Phase 3
9 Antidepressive Agents Phase 3
10 Dopamine Agents Phase 3
11 Duloxetine Hydrochloride Phase 3
12 Neurotransmitter Agents Phase 3
13 Neurotransmitter Uptake Inhibitors Phase 3
14 Peripheral Nervous System Agents Phase 3
15 Psychotropic Drugs Phase 3
16
Serotonin Phase 3 50-67-9 5202
17 Serotonin and Noradrenaline Reuptake Inhibitors Phase 3
18
Calcium Carbonate Approved Phase 2 471-34-1
19
Denosumab Approved Phase 1, Phase 2 615258-40-7
20
Cholecalciferol Approved, Nutraceutical Phase 2 67-97-0 6221 10883523 5280795
21
Ergocalciferol Approved, Nutraceutical Phase 2 50-14-6 5280793
22
Vitamin D Approved, Nutraceutical, Vet_approved Phase 2 1406-16-2
23 Calcium, Dietary Phase 2
24 Ergocalciferols Phase 2
25 Micronutrients Phase 2
26 Trace Elements Phase 2
27 Vitamins Phase 2
28 Hormone Antagonists Phase 1, Phase 2
29 Hormones Phase 1, Phase 2
30 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1, Phase 2
31 Calcium Supplement Nutraceutical Phase 2
32 Calciferol Nutraceutical Phase 2
33 Vitamin D2 Nutraceutical Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Bisphosphonate Therapy for Osteogenesis Imperfecta Completed NCT00159419 Phase 4 Alendronate;Pamidronate
2 Alendronate Osteoporosis Study Completed NCT00277251 Phase 2, Phase 3 Alendronate
3 A Study of Duloxetine in Adolescents With Juvenile Primary Fibromyalgia Syndrome Active, not recruiting NCT01237587 Phase 3 Duloxetine;Placebo
4 Phase II Study of Alendronate Sodium in Children With High-Turnover Idiopathic Juvenile Osteoporosis Completed NCT00010439 Phase 2 Alendronate
5 Safety and Efficacy of Alendronate (Fosamax) in Children With Osteoporosis Completed NCT00259857 Phase 2 Alendronate
6 Denosumab for Glucocorticoid-treated Children With Rheumatic Disorders Not yet recruiting NCT02418273 Phase 1, Phase 2 denosumab
7 Alendronate in Juvenile Osteoporosis Completed NCT00920075 Alendronate (Fosamax)
8 Spine Quantitative Computed Tomography (QCT) Completed NCT00762879
9 Steroid-Induced Osteoporosis in the Pediatric Population - Canadian Incidence Study Completed NCT01663129

Search NIH Clinical Center for Juvenile Primary Osteoporosis

Genetic Tests for Juvenile Primary Osteoporosis

Anatomical Context for Juvenile Primary Osteoporosis

MalaCards organs/tissues related to Juvenile Primary Osteoporosis:

39
Bone

Publications for Juvenile Primary Osteoporosis

Variations for Juvenile Primary Osteoporosis

Expression for Juvenile Primary Osteoporosis

Search GEO for disease gene expression data for Juvenile Primary Osteoporosis.

Pathways for Juvenile Primary Osteoporosis

GO Terms for Juvenile Primary Osteoporosis

Sources for Juvenile Primary Osteoporosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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