MCID: JVN010
MIFTS: 59

Juvenile Rheumatoid Arthritis malady

Genetic diseases, Rare diseases, Bone diseases categories

Aliases & Classifications for Juvenile Rheumatoid Arthritis

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Juvenile Rheumatoid Arthritis, Aliases & Descriptions:

Name: Juvenile Rheumatoid Arthritis 9 41 21 11 32
Juvenile Idiopathic Arthritis 9 41 21
Monarticular Juvenile Rheumatoid Arthritis 9 60
Systemic Juvenile Rheumatoid Arthritis 9 21
Juvenile Chronic Polyarthritis 9 60
Arthritis, Juvenile Rheumatoid 41 21
Juvenile Chronic Arthritis 41 21
Juvenile Arthritis 41 60
Rheumatoid Arthritis, Systemic Juvenile, Susceptibility to 10
Acute Polyarticular Juvenile Rheumatoid Arthritis 60
 
Pauciarticular Onset Juvenile Chronic Arthritis 9
Pauciarticular Juvenile Rheumatoid Arthritis 60
Rheumatoid Arthritis, Systemic Juvenile 60
Acute Juvenile Rheumatoid Arthritis 9
Pauciarticular Juvenile Arthritis 9
Arthritis Juvenile Rheumatoid 43
Juvenile Ra 21
Jra 21
Jia 21


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Bone diseases


Summaries for Juvenile Rheumatoid Arthritis

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MedlinePlus:32 Juvenile rheumatoid arthritis (jra) is a type of arthritis that happens in children age 16 or younger. it causes joint swelling, pain, stiffness, and loss of motion. it can affect any joint, and in some cases it can affect internal organs as well. one early sign of jra may be limping in the morning. symptoms can come and go. some children have just one or two flare-ups. others have symptoms that never go away. jra causes growth problems in some children. no one knows exactly what causes jra. scientists do know it is an autoimmune disorder, which means your immune system, which normally helps your body fight infection, attacks your body's own tissues. jra can be hard to diagnose. your health care provider may do a physical exam, lab tests, and x-rays. medicines and physical therapy can help maintain movement and reduce swelling and pain. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards based summary: Juvenile Rheumatoid Arthritis, also known as juvenile idiopathic arthritis, is related to arthritis and rheumatoid arthritis, and has symptoms including arthritis, arthralgia and autoimmunity. An important gene associated with Juvenile Rheumatoid Arthritis is IL6 (interleukin 6 (interferon, beta 2)), and among its related pathways are Hematopoietic cell lineage and Rheumatoid arthritis. The drugs diclofenac and aurothioglucose and the compounds clodronate and anaphylatoxin have been mentioned in the context of this disorder. Affiliated tissues include joint, skin and testes.

Disease Ontology:9 A rheumatoid arthritis that involves an autoimmune disease onset in children under 16 which attacks the healthy cells and tissue of located in joint.

Genetics Home Reference:21 Juvenile idiopathic arthritis refers to a group of conditions involving joint inflammation (arthritis) that first appears before the age of 16. This condition is an autoimmune disorder, which means that the immune system malfunctions and attacks the body's organs and tissues, in this case the joints.

Wikipedia:63 Juvenile idiopathic arthritis (JIA), also known as juvenile rheumatoid arthritis (JRA), is the most... more...

Related Diseases for Juvenile Rheumatoid Arthritis

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Diseases in the Rheumatoid Arthritis family:

Rheumatoid Arthritis, Systemic Juvenile juvenile rheumatoid arthritis

Diseases related to Juvenile Rheumatoid Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 209)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis32.4IL6, ACP5
2rheumatoid arthritis32.1HLA-DRB4, FCRL3, ACP5, IL6
3lupus erythematosus31.4C4A
4systemic lupus erythematosus31.4C4A
5synovitis31.3IL6
6iridocyclitis10.8
7uveitis10.8
8enthesitis-related arthritis10.8
9anterior uveitis10.7
10macrophage activation syndrome10.7
11spondyloarthropathy10.6
12pauciarticular onset juvenile idiopathic arthritis10.6
13enthesitis-related juvenile idiopathic arthritis10.5
14psoriatic juvenile idiopathic arthritis10.5
15leukemia10.5
16arthropathy10.5
17periodontitis10.5
18vasculitis10.5
19asthma10.4
20psoriatic arthritis10.4
21cataract10.4
22iritis10.4
23cerebritis10.4
24amyloidosis10.4
25dermatomyositis10.4
26lymphoblastic leukemia10.4
27polyarticular onset juvenile idiopathic arthritis10.4
28blindness10.4
29aggressive periodontitis10.4
30rubella10.4
31agammaglobulinemia10.4
32osteomyelitis10.4
33chronic recurrent multifocal osteomyelitis10.4
34periodontal disease10.4IL6
35arthropathy, progressive pseudorheumatoid, of childhood10.3
36rheumatoid arthritis, systemic juvenile10.3
37bronchiolitis obliterans10.3
38hepatitis10.3
39bronchiolitis10.3
40childhood leukemia10.3
41pneumonia10.3
42sickle cell disease10.3
43ramon syndrome10.3
44spondylarthropathy10.3
45systemic onset juvenile idiopathic arthritis10.3
46secondary amyloidosis10.3
47rheumatic disease10.3
48common variable immunodeficiency10.3
49crohn's disease10.3
50glomerulonephritis10.3

Graphical network of the top 20 diseases related to Juvenile Rheumatoid Arthritis:



Diseases related to juvenile rheumatoid arthritis

Symptoms for Juvenile Rheumatoid Arthritis

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HPO human phenotypes related to Juvenile Rheumatoid Arthritis:

(show all 23)
id Description Frequency HPO Source Accession
1 arthritis hallmark (90%) HP:0001369
2 arthralgia hallmark (90%) HP:0002829
3 autoimmunity hallmark (90%) HP:0002960
4 abnormality of temperature regulation hallmark (90%) HP:0004370
5 abnormal tendon morphology hallmark (90%) HP:0100261
6 abnormality of the urethra typical (50%) HP:0000795
7 hyperkeratosis typical (50%) HP:0000962
8 skin rash typical (50%) HP:0000988
9 abnormality of the fingernails typical (50%) HP:0001231
10 joint dislocation typical (50%) HP:0001373
11 limitation of joint mobility typical (50%) HP:0001376
12 joint swelling typical (50%) HP:0001386
13 malabsorption typical (50%) HP:0002024
14 abdominal pain typical (50%) HP:0002027
15 abnormality of the pleura typical (50%) HP:0002103
16 psoriasis typical (50%) HP:0003765
17 inflammatory abnormality of the eye typical (50%) HP:0100533
18 mediastinal lymphadenopathy typical (50%) HP:0100721
19 cartilage destruction typical (50%) HP:0100773
20 abnormality of the sacroiliac joint typical (50%) HP:0100781
21 abnormality of the pericardium occasional (7.5%) HP:0001697
22 splenomegaly occasional (7.5%) HP:0001744
23 hepatomegaly occasional (7.5%) HP:0002240

Drugs & Therapeutics for Juvenile Rheumatoid Arthritis

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Drug clinical trials:

Search ClinicalTrials for Juvenile Rheumatoid Arthritis

Search NIH Clinical Center for Juvenile Rheumatoid Arthritis

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Juvenile Rheumatoid Arthritis

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Anatomical Context for Juvenile Rheumatoid Arthritis

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MalaCards organs/tissues related to Juvenile Rheumatoid Arthritis:

31
Skin, Testes, Bone, T cells, Eye, Myeloid, Liver, Neutrophil, Monocytes, B cells, Retina, Kidney, Lung, Thyroid, Breast, Endothelial

FMA organs/tissues related to Juvenile Rheumatoid Arthritis:

14
Joint

Animal Models for Juvenile Rheumatoid Arthritis or affiliated genes

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Publications for Juvenile Rheumatoid Arthritis

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Articles related to Juvenile Rheumatoid Arthritis:

(show top 50)    (show all 581)
idTitleAuthorsYear
1
Association of neopterin as a marker of immune system activation and juvenile rheumatoid arthritis activity. (25727025)
2015
2
Dental surgery and anesthetic precautions of a patient with Down syndrome and juvenile rheumatoid arthritis: a case report. (23265174)
2012
3
Sexual maturation in boys with juvenile rheumatoid arthritis. (20429008)
2011
4
Hypersensitive joint reaction after etanercept treatment in a patient with juvenile rheumatoid arthritis. (21362794)
2011
5
Acute lymphoblastic leukemia masquerading as juvenile rheumatoid arthritis: diagnostic pitfall and association with survival. (19727722)
2010
6
Type 1 diabetes associated with Hashimoto's thyroiditis and juvenile rheumatoid arthritis: a case report with clinical and genetic investigations. (21118342)
2010
7
Biochemical markers of bone turnover associated with calcium supplementation in children with juvenile rheumatoid arthritis: results of a double-blind, placebo-controlled intervention trial. (19035501)
2008
8
Trials reveal promising options for treating juvenile rheumatoid arthritis. (18167400)
2008
9
Synovectomy of the hip in patients with juvenile rheumatoid arthritis. (17768196)
2007
10
Serum melatonin in juvenile rheumatoid arthritis: correlation with disease activity. (19069959)
2007
11
Improving adherence to medical regimens for juvenile rheumatoid arthritis. (17550635)
2007
12
Increased Fas and Bcl-2 expression on peripheral blood T and B lymphocytes from juvenile-onset systemic lupus erythematosus, but not from juvenile rheumatoid arthritis and juvenile dermatomyositis. (17162369)
2006
13
A randomized controlled trial of calcium supplementation to increase bone mineral density in children with juvenile rheumatoid arthritis. (16802360)
2006
14
Etanercept therapy in children with juvenile rheumatoid arthritis. (16341346)
2005
15
Novel approaches to gene expression analysis of active polyarticular juvenile rheumatoid arthritis. (14979934)
2004
16
Another patient with chromosome 18 deletion syndrome and juvenile rheumatoid arthritis. (15124264)
2004
17
Effective use of the recombinant interleukin 1 receptor antagonist anakinra in therapy resistant systemic onset juvenile rheumatoid arthritis. (15468378)
2004
18
Favorable outcome in patients with renal involvement complicating macrophage activation syndrome in systemic onset juvenile rheumatoid arthritis. (15468377)
2004
19
Comparing the self-reported referral and management preferences of pediatricians and family physicians for children with juvenile rheumatoid arthritis. (14719216)
2003
20
Brief report: adjustment to juvenile rheumatoid arthritis: a family systems perspective. (12808011)
2003
21
A controlled longitudinal study of the social functioning of children with juvenile rheumatoid arthritis. (12490627)
2003
22
The significance of elevated serologic markers of celiac disease in children with juvenile rheumatoid arthritis. (19861810)
2003
23
Elbow synovectomy on patients with juvenile rheumatoid arthritis. (12838054)
2003
24
Growth patterns in juvenile rheumatoid arthritis. (14611121)
2003
25
Methotrexate inhibits interleukin-6 production in patients with juvenile rheumatoid arthritis. (12739045)
2003
26
Polymorphism of human HLA-DRB1 leukocyte antigen alleles and its association to juvenile rheumatoid arthritis in a sample of Colombian mestizo children]. (14582328)
2003
27
High response rate in the phase I/II study of meloxicam in juvenile rheumatoid arthritis. (12022326)
2002
28
Etanercept: an updated review of its use in rheumatoid arthritis, psoriatic arthritis and juvenile rheumatoid arthritis. (12421111)
2002
29
The prevalence of uveitis in juvenile rheumatoid arthritis. (11182663)
2001
30
Antioxidant enzymes levels in children with juvenile rheumatoid arthritis. (12092181)
2001
31
What's new in the diagnosis and treatment of juvenile rheumatoid arthritis. (10912594)
2000
32
Interleukin 8 and monocyte chemoattractant protein-1 in patients with juvenile rheumatoid arthritis. Relation to onset types, disease activity, and synovial fluid leukocytes. (9972980)
1999
33
Juvenile rheumatoid arthritis. (10503657)
1999
34
On beyond methotrexate treatment of severe juvenile rheumatoid arthritis. (10464566)
1999
35
Clinical relevance of IgA rheumatoid factor (RF) in children with juvenile rheumatoid arthritis. (10651082)
1999
36
Pharmacokinetics of etodolac in patients with stable juvenile rheumatoid arthritis. (10566567)
1999
37
Psychological symptoms in chronic fatigue and juvenile rheumatoid arthritis. (10224175)
1999
38
Juvenile rheumatoid arthritis in a Canadian First Nations (aboriginal) population: onset subtypes and HLA associations. (9558186)
1998
39
Juvenile rheumatoid arthritis and common variable hypogammaglobulinemia. (9632087)
1998
40
Felty syndrome complicating juvenile rheumatoid arthritis. (9787332)
1998
41
Transmission disequilibrium as a test of linkage and association between HLA alleles and pauciarticular-onset juvenile rheumatoid arthritis. (9751094)
1998
42
Juvenile rheumatoid arthritis: ethnic differences in diagnostic types. (9292786)
1997
43
Polymorphism in the LMP2 gene influences disease susceptibility and severity in HLA-B27 associated juvenile rheumatoid arthritis. (8730138)
1996
44
Elevated circulating interleukin-7 levels in patients with systemic juvenile rheumatoid arthritis. (7473488)
1995
45
Cytokine levels in serum and synovial fluid of patients with juvenile rheumatoid arthritis. (7699643)
1994
46
A novel autoantibody to the putative oncoprotein DEK in pauciarticular onset juvenile rheumatoid arthritis. (7869324)
1994
47
Intravenous immunoglobulin in the treatment of systemic juvenile rheumatoid arthritis: a randomized placebo controlled trial. Pediatric Rheumatology Collaborative Study Group. (7699642)
1994
48
Reye syndrome and juvenile rheumatoid arthritis in Michigan. (4036917)
1985
49
Iridocyclitis and pauciarticular juvenile rheumatoid arthritis. (5104123)
1971
50
Chronic iridocyclitis in juvenile rheumatoid arthritis. (5310717)
1970

Variations for Juvenile Rheumatoid Arthritis

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Expression for genes affiliated with Juvenile Rheumatoid Arthritis

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Search GEO for disease gene expression data for Juvenile Rheumatoid Arthritis.

Pathways for genes affiliated with Juvenile Rheumatoid Arthritis

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Pathways related to Juvenile Rheumatoid Arthritis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8IL6, HLA-DRB4
29.3HLA-DRB4, ACP5, IL6
3
Show member pathways
9.2HLA-DRB4, IL6, C4A
4
Show member pathways
Complement Activation, Classical Pathway36
Complement and Coagulation Cascades36
9.0C4B, C4A
5
Show member pathways
Immune response Alternative complement pathway58
Immune response Lectin Induced complement pathway58
Immune response Classic complement pathway58
9.0C4B, C4A
68.7C4B, C4A, IL6
78.7C4B, C4A, IL6
88.7C4B, C4A, HLA-DRB4
9
Show member pathways
8.7HLA-DRB4, C4A, C4B

Compounds for genes affiliated with Juvenile Rheumatoid Arthritis

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Sources:
43Novoseek, 49PharmGKB, 12DrugBank
See all sources

Compounds related to Juvenile Rheumatoid Arthritis according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
1clodronate43 49 1211.6IL6, ACP5
2anaphylatoxin439.6C4A, IL6
3pmma439.4IL6, ACP5

GO Terms for genes affiliated with Juvenile Rheumatoid Arthritis

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Biological processes related to Juvenile Rheumatoid Arthritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1defense response to Gram-positive bacteriumGO:00508309.7IL6, ACP5
2negative regulation of tumor necrosis factor productionGO:00327209.6NFKBIL1, ACP5
3regulation of complement activationGO:00304499.1C4B, C4A
4complement activation, classical pathwayGO:00069589.0C4B, C4A
5complement activationGO:00069568.7C4B, C4A
6inflammatory responseGO:00069548.6IL6, C4A, C4B

Molecular functions related to Juvenile Rheumatoid Arthritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endopeptidase inhibitor activityGO:00048669.0C4B, C4A

Products for genes affiliated with Juvenile Rheumatoid Arthritis

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  • Kits and Assays

Sources for Juvenile Rheumatoid Arthritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet