JIA
MCID: JVN010
MIFTS: 67

Juvenile Rheumatoid Arthritis (JIA) malady

Respiratory diseases, Bone diseases categories

Summaries for Juvenile Rheumatoid Arthritis

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8Disease Ontology, 21Genetics Home Reference, 33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Juvenile rheumatoid arthritis (jra) is a type of arthritis that happens in children age 16 or younger. it causes joint swelling, pain, stiffness, and loss of motion. it can affect any joint, and in some cases it can affect internal organs as well. one early sign of jra may be limping in the morning. symptoms can come and go. some children have just one or two flare-ups. others have symptoms that never go away. jra causes growth problems in some children. no one knows exactly what causes jra. scientists do know it is an autoimmune disorder, which means your immune system, which normally helps your body fight infection, attacks your body's own tissues. jra can be hard to diagnose. your health care provider may do a physical exam, lab tests, and x-rays. medicines and physical therapy can help maintain movement and reduce swelling and pain. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Juvenile Rheumatoid Arthritis, also known as rheumatoid arthritis, systemic juvenile, is related to arthritis and rheumatoid arthritis, and has symptoms including splenomegaly, arthritis/synovitis/synovial proliferation and fever/chilling. An important gene associated with Juvenile Rheumatoid Arthritis is IL6 (interleukin 6 (interferon, beta 2)), and among its related pathways are Rheumatoid arthritis and Interleukin-3, 5 and GM-CSF signaling. The compounds pmma and pf 04217903 mesylate have been mentioned in the context of this disorder. Affiliated tissues include joint, testes and skin, and related mouse phenotype hematopoietic system.

Disease Ontology:8 A rheumatoid arthritis that involves an autoimmune disease onset in children under 16 which attacks the healthy cells and tissue of located in joint.

Genetics Home Reference:21 Juvenile idiopathic arthritis refers to a group of conditions involving joint inflammation (arthritis) that first appears before the age of 16. This condition is an autoimmune disorder, which means that the immune system malfunctions and attacks the body's organs and tissues, in this case the joints.

Wikipedia:63 Juvenile idiopathic arthritis (JIA), also known as juvenile rheumatoid arthritis (JRA), is the most... more...

Description from OMIM:46 604302

Aliases & Classifications for Juvenile Rheumatoid Arthritis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 21Genetics Home Reference, 46OMIM, 10DISEASES, 44Novoseek, 48Orphanet, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 27ICD9CM, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases, Bone diseases


Characteristics (Orphanet epidemiological data):

48
systemic-onset juvenile idiopathic arthritis:
Prevalence: 1-9/100000; Age of onset: Childhood; Age of death: Normal


Aliases & Descriptions:

juvenile rheumatoid arthritis 8 42 21 10 33
rheumatoid arthritis, systemic juvenile 46 44 60
arthritis, juvenile rheumatoid 42 21 60
juvenile idiopathic arthritis 8 42 21
monarticular juvenile rheumatoid arthritis 8 60
juvenile chronic polyarthritis 8 60
juvenile chronic arthritis 42 21
acute polyarticular juvenile rheumatoid arthritis 60
pauciarticular onset juvenile chronic arthritis 8
systemic-onset juvenile idiopathic arthritis 48
systemic juvenile rheumatoid arthritis 21
acute juvenile rheumatoid arthritis 8
pauciarticular juvenile arthritis 8
arthritis juvenile rheumatoid 44
juvenile-onset still disease 60
systemic polyarthritis 48
juvenile arthritis 42
still disease 48
juvenile ra 21
jra 21
jia 21


External Ids:

Disease Ontology8 DOID:676
ICD9CM27 714.31
SNOMED-CT via Orphanet57 201796004, 410794002
OMIM46 604302
ICD10 via Orphanet26 M08.2

Related Diseases for Juvenile Rheumatoid Arthritis

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Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Rheumatoid Arthritis family:

juvenile rheumatoid arthritis

Diseases related to Juvenile Rheumatoid Arthritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 218)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis32.3ACP5, S100A12, PSMB9, MIF, IL2RB, IL6
2rheumatoid arthritis32.3S100A12, HLA-DRB4, MIF, IL2RB, IL6, ACP5
3lupus erythematosus31.0C4A
4systemic lupus erythematosus31.0C4B, DEK, MIF, CYP21A1P, IL2RB, IL6
5synovitis30.8IL6
6leukemia30.7DEK, MAGEA1, IL2RB, IL6, ACP5
7asthma30.5S100A12, MIF
8sarcoidosis30.4IL2RB, MIF
9hepatitis30.4IL2RB, MAGEA1, HGF
10glomerulonephritis30.4MIF
11psoriasis30.2S100A12, IL6
12diabetes mellitus30.2IL6
13sarcoma30.2MAGEA1
14osteoarthritis30.2ACP5, IL6
15hepatitis b30.2MIF, MAGEA1
16kawasaki disease30.2S100A12
17meningitis30.2IL6
18melanoma30.2HGF, PSMB9, DEK, MAGEA1, IL2RB, TAPBP
19pulmonary fibrosis30.2HGF
20graves' disease30.1PSMB9
21inflammatory bowel disease30.1IL6, S100A12
22influenza30.1IL2RB, PSMB9
23peritonitis30.1IL6
24iridocyclitis10.8
25uveitis10.8
26spondyloarthropathy10.6
27pauciarticular onset juvenile idiopathic arthritis10.5
28arthropathy10.5
29periodontitis10.5
30enthesitis-related juvenile idiopathic arthritis10.5
31reactive arthritis10.4
32vasculitis10.4
33iritis10.4
34cerebritis10.4
35psoriatic arthritis10.4
36juvenile glaucoma10.4
37acute leukemia10.4
38amyloidosis10.4
39cataract10.4
40dermatomyositis10.4
41glaucoma10.4
42lymphoblastic leukemia10.4
43polyarticular onset juvenile idiopathic arthritis10.4
44rubella10.3
45aggressive periodontitis10.3
46psoriatic juvenile idiopathic arthritis10.3
47bronchiolitis obliterans10.3
48bronchiolitis10.3
49childhood leukemia10.3
50hodgkin's lymphoma10.3

Graphical network of the top 20 diseases related to Juvenile Rheumatoid Arthritis:



Diseases related to juvenile rheumatoid arthritis

Clinical Features for Juvenile Rheumatoid Arthritis

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Sources:
46OMIM, 48Orphanet
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Clinical features from OMIM:

604302

Symptoms:

48 (show all 13)
  • splenomegaly
  • arthritis/synovitis/synovial proliferation
  • fever/chilling
  • articular/joint pain/arthralgia
  • hydrarthrosis/articular/joint effusion
  • cutaneous rash
  • autoimmunity/autoimmune reaction/autoantibodies
  • acute abdominal pain/colic
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • mediastinal/hilar adenopathies
  • hepatomegaly/liver enlargement (excluding storage disease)

Drugs & Therapeutics for Juvenile Rheumatoid Arthritis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Juvenile Rheumatoid Arthritis

Drug clinical trials:

Search ClinicalTrials for Juvenile Rheumatoid Arthritis

Search NIH Clinical Center for Juvenile Rheumatoid Arthritis

Search CenterWatch for Juvenile Rheumatoid Arthritis

Genetic Tests for Juvenile Rheumatoid Arthritis

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Anatomical Context for Juvenile Rheumatoid Arthritis

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Juvenile Rheumatoid Arthritis:

32
Testes, Skin, Bone, T cells, Liver, Myeloid, Monocytes, B cells, Whole blood, Eye, Endothelial, Kidney, Lung, Breast, Thyroid, Retina

FMA organs/tissues related to Juvenile Rheumatoid Arthritis:

14
Joint

Animal Models for Juvenile Rheumatoid Arthritis or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Juvenile Rheumatoid Arthritis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539710.4TAPBP, IL6, IL2RB, MIF, SH2D2A, C4B

Publications for Juvenile Rheumatoid Arthritis

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Sources:
50PubMed
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Articles related to Juvenile Rheumatoid Arthritis:

(show top 50)    (show all 601)
idTitleAuthorsYear
1
Juvenile rheumatoid arthritis. (23763801)
2013
2
Investigation of rheumatoid arthritis susceptibility loci in juvenile idiopathic arthritis confirms high degree of overlap. (22294642)
2012
3
Measures of health status and quality of life in juvenile rheumatoid arthritis: Pediatric Quality of Life Inventory (PedsQL) Rheumatology Module 3.0, Juvenile Arthritis Quality of Life Questionnaire (JAQQ), Paediatric Rheumatology Quality of Life Scale (PRQL), and Childhood Arthritis Health Profile (CAHP). (22588764)
2011
4
Prevalence of IgA deficiency in children with juvenile rheumatoid arthritis. (21358013)
2011
5
Acute lymphoblastic leukemia masquerading as juvenile rheumatoid arthritis: no association with survival. (20177895)
2010
6
FDA advisers endorse Celebrex for juvenile rheumatoid arthritis: lack of studies in children raises safety concerns. (17189564)
2007
7
Charnley low-frictional torque arthroplasty in young rheumatoid and juvenile rheumatoid arthritis: 292 hips followed for an average of 15 years. (17464608)
2007
8
Increased Fas and Bcl-2 expression on peripheral blood T and B lymphocytes from juvenile-onset systemic lupus erythematosus, but not from juvenile rheumatoid arthritis and juvenile dermatomyositis. (17162369)
2006
9
A randomized controlled trial of calcium supplementation to increase bone mineral density in children with juvenile rheumatoid arthritis. (16802360)
2006
10
Ophthalmologic examinations in children with juvenile rheumatoid arthritis. (16651348)
2006
11
Evidence for chronic, peripheral activation of neutrophils in polyarticular juvenile rheumatoid arthritis. (17002793)
2006
12
Orthopedic surgical management of hip and knee involvement in patients with juvenile rheumatoid arthritis. (16584079)
2006
13
Systemic juvenile rheumatoid arthritis: cognitive function and social adjustment. (16178013)
2005
14
Quantitative magnetic resonance imaging of the hands and wrists of children with juvenile rheumatoid arthritis. (16142882)
2005
15
Prevention of osteoporosis: a randomized clinical trial to increase calcium intake in children with juvenile rheumatoid arthritis. (15944165)
2005
16
Complex genetic predisposition in adult and juvenile rheumatoid arthritis. (15018649)
2004
17
Outcome in juvenile rheumatoid arthritis in India. (15004305)
2004
18
Elbow synovectomy on patients with juvenile rheumatoid arthritis. (12838054)
2003
19
Harlequin ichthyosis in association with hypothyroidism and juvenile rheumatoid arthritis. (14521561)
2003
20
Coexistent sickle cell disease and juvenile rheumatoid arthritis: 2 cases with delayed diagnosis and severe destructive arthropathy. (12180751)
2002
21
Synovial sarcoma with extended occult period treated as juvenile rheumatoid arthritis: a case report. (12355132)
2002
22
The safety and efficacy of chicken type II collagen on uveitis associated with juvenile rheumatoid arthritis. (12778344)
2002
23
Preliminary definition of disease flare in juvenile rheumatoid arthritis. (12022323)
2002
24
Parvovirus B19 in the acute arthropathies and juvenile rheumatoid arthritis. (12173996)
2002
25
Bronchiolitis obliterans in a case of juvenile rheumatoid arthritis presented with pneumomediastinum. (11844973)
2002
26
Prevention of nonadherence to nonsteroidal anti-inflammatory medications for newly diagnosed patients with juvenile rheumatoid arthritis. (12433016)
2002
27
Intense immunosuppression followed by purified blood CD34+ cell autografting in a patient with refractory juvenile rheumatoid arthritis. (11277183)
2001
28
Adenosine deaminase activity and its isoenzyme pattern in patients with juvenile rheumatoid arthritis and systemic lupus erythematosus. (11771524)
2001
29
Isolated tuberculous monoarthritis mimicking oligoarticular juvenile rheumatoid arthritis. (11196526)
2001
30
Role of IgM & IgA rheumatoid factors in complement activation in patients with juvenile rheumatoid arthritis. (10937386)
2000
31
Bone mineral status in juvenile rheumatoid arthritis. (10782854)
2000
32
T-cell and T-cell receptor abnormalities in the immunopathogenesis of juvenile rheumatoid arthritis. (10990179)
2000
33
Psychological symptoms in chronic fatigue and juvenile rheumatoid arthritis. (10224175)
1999
34
Treatment of juvenile rheumatoid arthritis. (10517078)
1999
35
Family-level coping in juvenile rheumatoid arthritis: assessing the utility of a quantitative family interview. (11081000)
1999
36
An unequal crossover between the RCCX modules of the human MHC leading to the presence of a CYP21B gene and a tenascin TNXB/TNXA-RP2 recombinant between C4A and C4B genes in a patient with juvenile rheumatoid arthritis. (10343159)
1999
37
A population-based study on uveitis in juvenile rheumatoid arthritis. (10084046)
1999
38
Juvenile rheumatoid arthritis and common variable hypogammaglobulinemia. (9632087)
1998
39
Systemic juvenile rheumatoid arthritis complicated by two different renal lesions. (9543367)
1998
40
Torticollis as the sole initial presenting sign of systemic onset juvenile rheumatoid arthritis. (9458223)
1998
41
Intra-articular corticosteroids in the treatment of juvenile rheumatoid arthritis. (9746864)
1998
42
Juvenile rheumatoid arthritis. Effects of disease activity and recombinant human growth hormone on insulin-like growth factor 1, insulin-like growth factor binding proteins 1 and 3, and osteocalcin. (9041945)
1997
43
Immunity to cartilage link protein in patients with juvenile rheumatoid arthritis. (9150089)
1997
44
Autoreactivity to human heat-shock protein 60 predicts disease remission in oligoarticular juvenile rheumatoid arthritis. (8912504)
1996
45
Elevated circulating interleukin-7 levels in patients with systemic juvenile rheumatoid arthritis. (7473488)
1995
46
Iris protein antibodies in serum of patients with juvenile rheumatoid arthritis and uveitis. (8481650)
1993
47
Dominant T-cell-receptor beta chain variable region V beta 14+ clones in juvenile rheumatoid arthritis. (8248215)
1993
48
The putative oncoprotein DEK, part of a chimera protein associated with acute myeloid leukaemia, is an autoantigen in juvenile rheumatoid arthritis. (8252804)
1993
49
The significance of antinuclear antibodies in juvenile rheumatoid arthritis associated with chronic bilateral iridocyclitis. (6982590)
1982
50
Iridocyclitis associated with juvenile rheumatoid arthritis. (1172374)
1975

Genetic Variations for Juvenile Rheumatoid Arthritis

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Expression for genes affiliated with Juvenile Rheumatoid Arthritis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Juvenile Rheumatoid Arthritis

Search GEO for disease gene expression data for Juvenile Rheumatoid Arthritis.

Pathways for genes affiliated with Juvenile Rheumatoid Arthritis

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29KEGG, 53Reactome
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Compounds for genes affiliated with Juvenile Rheumatoid Arthritis

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Sources:
44Novoseek, 59Tocris Bioscience, 49PharmGKB, 11DrugBank, 24HMDB
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Compounds related to Juvenile Rheumatoid Arthritis according to GeneCards/GeneDecks:

(show all 20)
idCompoundScoreTop Affiliating Genes
1pmma4410.8ACP5, IL6, HGF
2pf 04217903 mesylate5910.8HGF, IL6
3su 112745910.8HGF, IL6
4pha 6657525910.7HGF, IL6
5endotoxin4410.7IL6, IL2RB, MIF, C4A, TNXA
6creatinine4410.7HGF, TNXA, MIF, IL2RB, IL6, ACP5
7rebamipide4410.7HGF, IL6
8crizotinib49 5911.7HGF, IL6
9ivig4410.7IL6, IL2RB, S100A12
10steroid4410.7TNXA, C4A, C4B, MIF, CYP21A1P, IL2RB
11alanine4410.6HGF, TNXA, MIF, IL2RB, IL6, TAPBP
12rantes4410.6ACP5, IL6, IL2RB
13polyacrylamide4410.6S100A12, TNXA, MIF, ACP5
14Intravenous Immunoglobulin1110.6C4A, C4B
15thalidomide44 49 59 1113.6IL6, MIF, HGF
16polysaccharide4410.5TAPBP, IL2RB, TNXA, HGF
17serine4410.5IL2RB, MIF
18olopatadine44 1111.5S100A12, IL6
19leukotriene b444 59 2412.3ACP5, IL6, IL2RB
20norepinephrine44 11 2412.2IL2RB

GO Terms for genes affiliated with Juvenile Rheumatoid Arthritis

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16Gene Ontology
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Cellular components related to Juvenile Rheumatoid Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.4HMGB2, IL6, MIF, C4B, C4A, HGF

Biological processes related to Juvenile Rheumatoid Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of apoptotic processGO:04306610.5HMGB2, HGF, PSMB9, MIF, IL2RB, IL6
2monocyte chemotaxisGO:00254810.4IL6, S100A12
3positive chemotaxisGO:05091810.4HMGB2, MIF, HGF
4inflammatory responseGO:00695410.3S100A12, C4A, C4B, MIF, IL6
5positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.2IL6, MIF, HGF

Molecular functions related to Juvenile Rheumatoid Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RAGE receptor bindingGO:05078610.4HMGB2, S100A12
2chemoattractant activityGO:04205610.1HMGB2, MIF, HGF

Products for genes affiliated with Juvenile Rheumatoid Arthritis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Juvenile Rheumatoid Arthritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet