JIA
MCID: JVN010
MIFTS: 67

Juvenile Rheumatoid Arthritis (JIA) malady

Respiratory diseases, Bone diseases categories

Summaries for Juvenile Rheumatoid Arthritis

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8Disease Ontology, 21Genetics Home Reference, 33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Juvenile rheumatoid arthritis (jra) is a type of arthritis that happens in children age 16 or younger. it causes joint swelling, pain, stiffness, and loss of motion. it can affect any joint, and in some cases it can affect internal organs as well. one early sign of jra may be limping in the morning. symptoms can come and go. some children have just one or two flare-ups. others have symptoms that never go away. jra causes growth problems in some children. no one knows exactly what causes jra. scientists do know it is an autoimmune disorder, which means your immune system, which normally helps your body fight infection, attacks your body's own tissues. jra can be hard to diagnose. your health care provider may do a physical exam, lab tests, and x-rays. medicines and physical therapy can help maintain movement and reduce swelling and pain. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Juvenile Rheumatoid Arthritis, also known as rheumatoid arthritis, systemic juvenile, is related to arthritis and rheumatoid arthritis, and has symptoms including splenomegaly, arthritis/synovitis/synovial proliferation and fever/chilling. An important gene associated with Juvenile Rheumatoid Arthritis is IL6 (interleukin 6 (interferon, beta 2)), and among its related pathways are Rheumatoid arthritis and Interleukin-3, 5 and GM-CSF signaling. The compounds pmma and pf 04217903 mesylate have been mentioned in the context of this disorder. Affiliated tissues include joint, testes and skin, and related mouse phenotype hematopoietic system.

Disease Ontology:8 A rheumatoid arthritis that involves an autoimmune disease onset in children under 16 which attacks the healthy cells and tissue of located in joint.

Genetics Home Reference:21 Juvenile idiopathic arthritis refers to a group of conditions involving joint inflammation (arthritis) that first appears before the age of 16. This condition is an autoimmune disorder, which means that the immune system malfunctions and attacks the body's organs and tissues, in this case the joints.

Wikipedia:63 Juvenile idiopathic arthritis (JIA), also known as juvenile rheumatoid arthritis (JRA), is the most... more...

Description from OMIM:46 604302

Aliases & Classifications for Juvenile Rheumatoid Arthritis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 21Genetics Home Reference, 10DISEASES, 33MedlinePlus, 60UMLS, 46OMIM, 44Novoseek, 48Orphanet, 56SNOMED-CT, 27ICD9CM, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases, Bone diseases


Characteristics (Orphanet epidemiological data):

48
systemic-onset juvenile idiopathic arthritis:
Prevalence: 1-9/100000; Age of onset: Childhood; Age of death: Normal


Aliases & Descriptions:

juvenile rheumatoid arthritis 8 42 21 10 33
rheumatoid arthritis, systemic juvenile 46 44 60
arthritis, juvenile rheumatoid 42 21 60
juvenile idiopathic arthritis 8 42 21
monarticular juvenile rheumatoid arthritis 8 60
juvenile chronic polyarthritis 8 60
juvenile chronic arthritis 42 21
acute polyarticular juvenile rheumatoid arthritis 60
pauciarticular onset juvenile chronic arthritis 8
systemic-onset juvenile idiopathic arthritis 48
systemic juvenile rheumatoid arthritis 21
acute juvenile rheumatoid arthritis 8
pauciarticular juvenile arthritis 8
arthritis juvenile rheumatoid 44
juvenile-onset still disease 60
systemic polyarthritis 48
juvenile arthritis 42
still disease 48
juvenile ra 21
jra 21
jia 21


External Ids:

Disease Ontology8 DOID:676
ICD9CM27 714.31
SNOMED-CT via Orphanet57 201796004, 410794002
OMIM46 604302
ICD10 via Orphanet26 M08.2

Related Diseases for Juvenile Rheumatoid Arthritis

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Rheumatoid Arthritis family:

juvenile rheumatoid arthritis

Diseases related to Juvenile Rheumatoid Arthritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 218)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis32.3ACP5, S100A12, PSMB9, MIF, IL2RB, IL6
2rheumatoid arthritis32.3S100A12, HLA-DRB4, MIF, IL2RB, IL6, ACP5
3lupus erythematosus31.0C4A
4systemic lupus erythematosus31.0C4B, DEK, MIF, CYP21A1P, IL2RB, IL6
5synovitis30.8IL6
6leukemia30.7DEK, MAGEA1, IL2RB, IL6, ACP5
7asthma30.5S100A12, MIF
8sarcoidosis30.4IL2RB, MIF
9hepatitis30.4IL2RB, MAGEA1, HGF
10glomerulonephritis30.4MIF
11psoriasis30.2S100A12, IL6
12diabetes mellitus30.2IL6
13sarcoma30.2MAGEA1
14osteoarthritis30.2ACP5, IL6
15hepatitis b30.2MIF, MAGEA1
16kawasaki disease30.2S100A12
17meningitis30.2IL6
18melanoma30.2HGF, PSMB9, DEK, MAGEA1, IL2RB, TAPBP
19pulmonary fibrosis30.2HGF
20graves' disease30.1PSMB9
21inflammatory bowel disease30.1IL6, S100A12
22influenza30.1IL2RB, PSMB9
23peritonitis30.1IL6
24iridocyclitis10.8
25uveitis10.8
26spondyloarthropathy10.6
27pauciarticular onset juvenile idiopathic arthritis10.5
28arthropathy10.5
29periodontitis10.5
30enthesitis-related juvenile idiopathic arthritis10.5
31reactive arthritis10.4
32vasculitis10.4
33iritis10.4
34cerebritis10.4
35psoriatic arthritis10.4
36juvenile glaucoma10.4
37acute leukemia10.4
38amyloidosis10.4
39cataract10.4
40dermatomyositis10.4
41glaucoma10.4
42lymphoblastic leukemia10.4
43polyarticular onset juvenile idiopathic arthritis10.4
44rubella10.3
45aggressive periodontitis10.3
46psoriatic juvenile idiopathic arthritis10.3
47bronchiolitis obliterans10.3
48bronchiolitis10.3
49childhood leukemia10.3
50hodgkin's lymphoma10.3

Graphical network of the top 20 diseases related to Juvenile Rheumatoid Arthritis:



Diseases related to juvenile rheumatoid arthritis

Clinical Features for Juvenile Rheumatoid Arthritis

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Sources:
46OMIM, 48Orphanet
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Clinical features from OMIM:

604302

Symptoms:

48 (show all 13)
  • splenomegaly
  • arthritis/synovitis/synovial proliferation
  • fever/chilling
  • articular/joint pain/arthralgia
  • hydrarthrosis/articular/joint effusion
  • cutaneous rash
  • autoimmunity/autoimmune reaction/autoantibodies
  • acute abdominal pain/colic
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • mediastinal/hilar adenopathies
  • hepatomegaly/liver enlargement (excluding storage disease)

Drugs & Therapeutics for Juvenile Rheumatoid Arthritis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Juvenile Rheumatoid Arthritis

Drug clinical trials:

Search ClinicalTrials for Juvenile Rheumatoid Arthritis

Search NIH Clinical Center for Juvenile Rheumatoid Arthritis

Search CenterWatch for Juvenile Rheumatoid Arthritis

Genetic Tests for Juvenile Rheumatoid Arthritis

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Anatomical Context for Juvenile Rheumatoid Arthritis

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Juvenile Rheumatoid Arthritis:

32
Testes, Skin, Bone, T cells, Liver, Myeloid, Monocytes, B cells, Whole blood, Eye, Endothelial, Kidney, Lung, Breast, Thyroid, Retina

FMA organs/tissues related to Juvenile Rheumatoid Arthritis:

14
Joint

Animal Models for Juvenile Rheumatoid Arthritis or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Juvenile Rheumatoid Arthritis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539710.4TAPBP, IL6, IL2RB, MIF, SH2D2A, C4B

Publications for Juvenile Rheumatoid Arthritis

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Sources:
50PubMed
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Articles related to Juvenile Rheumatoid Arthritis:

(show top 50)    (show all 601)
idTitleAuthorsYear
1
Sexual maturation in Egyptian boys and girls with juvenile rheumatoid arthritis. (23430157)
2013
2
Dosing celecoxib in pediatric patients with juvenile rheumatoid arthritis. (21878579)
2012
3
Study of serological and clinical factors among juvenile rheumatoid arthritis cases admitted to Mofid Children's Hospital and Imam Hossein Hospital, Tehran, Iran. (21970211)
2011
4
Follistatin-like protein 1 is a mesenchyme-derived inflammatory protein and may represent a biomarker for systemic-onset juvenile rheumatoid arthritis. (20506332)
2010
5
The FCRL3 -169T>C polymorphism is associated with rheumatoid arthritis and shows suggestive evidence of involvement with juvenile idiopathic arthritis in a Scandinavian panel of autoimmune diseases. (18065500)
2008
6
Synovectomy of the hip in patients with juvenile rheumatoid arthritis. (17768196)
2007
7
Incidence and outcomes of uveitis in juvenile rheumatoid arthritis, a synthesis of the literature. (16228217)
2006
8
Macrophage activation syndrome in juvenile rheumatoid arthritis successfully treated with cyclosporine A: a case report. (17179701)
2006
9
Care of the adult with juvenile rheumatoid arthritis. (16583404)
2006
10
Association of SLC11A1 (NRAMP1) with persistent oligoarticular and polyarticular rheumatoid factor-negative juvenile idiopathic arthritis in Finnish patients: haplotype analysis in Finnish families. (15641099)
2005
11
Cataract surgery and intraocular lens implantation in children with juvenile rheumatoid arthritis associated uveitis. (16193679)
2005
12
Total knee replacement in juvenile rheumatoid arthritis. (15682575)
2005
13
Assessment of left ventricular systolic and diastolic function in juvenile rheumatoid arthritis. (15623966)
2004
14
Autoantibodies to chromatin: prevalence and clinical significance in juvenile rheumatoid arthritis. (15301253)
2004
15
Brief report: adjustment to juvenile rheumatoid arthritis: a family systems perspective. (12808011)
2003
16
The significance of elevated serologic markers of celiac disease in children with juvenile rheumatoid arthritis. (19861810)
2003
17
The decreasing prevalence of uveitis associated with juvenile rheumatoid arthritis: do NSAIDs play a role? (17041450)
2003
18
Interactions between children with juvenile rheumatoid arthritis and their mothers. (12654947)
2003
19
Early predictors of longterm outcome in patients with juvenile rheumatoid arthritis: subset-specific correlations. (12610821)
2003
20
Brief report: child-rearing practices of caregivers with and without a child with juvenile rheumatoid arthritis: perspectives of caregivers and professionals. (12730284)
2003
21
Non-HLA gene polymorphisms in juvenile rheumatoid arthritis. (14611119)
2003
22
Immunoglobulin E-rheumatoid factor in juvenile rheumatoid arthritis. (12436177)
2002
23
A follow-up study of juvenile rheumatoid arthritis into adulthood. (12421027)
2002
24
Ultrasonography of the hip in the evaluation of children with seronegative juvenile rheumatoid arthritis. (11908582)
2002
25
Interferon-gamma:interleukin 4 ratios and associated type 1 cytokine expression in juvenile rheumatoid arthritis synovial tissue. (11838858)
2002
26
Attained adult height in juvenile rheumatoid arthritis with or without corticosteroid treatment. (12223982)
2002
27
Expression of angiogenic factors in juvenile rheumatoid arthritis: correlation with revascularization of human synovium engrafted into SCID mice. (11315918)
2001
28
Transient remission of intractable systemic-type of juvenile rheumatoid arthritis after chickenpox in a 2-year-old boy. (11208011)
2001
29
Radiologic mimics of juvenile rheumatoid arthritis. (11373918)
2001
30
Could hormones make a difference in the treatment of juvenile rheumatoid arthritis? (18034514)
2000
31
Pulmonary hemosiderosis with juvenile rheumatoid arthritis: a case report. (10936982)
2000
32
Epstein-Barr virus-associated Hodgkin's lymphoma and legionella pneumophila infection complicating treatment of juvenile rheumatoid arthritis with methotrexate and cyclosporine A. (10685644)
2000
33
Pharmacokinetics of etodolac in patients with stable juvenile rheumatoid arthritis. (10566567)
1999
34
Use of ELISA to measure antinuclear antibodies in children with juvenile rheumatoid arthritis. (10451083)
1999
35
Age-specific effects of juvenile rheumatoid arthritis-associated HLA alleles. (10513798)
1999
36
Remission of juvenile rheumatoid arthritis after infection with parvovirus B19. (10555914)
1999
37
Juvenile rheumatoid arthritis and del(22q11) syndrome: a non-random association. (9832043)
1998
38
Screening for uveitis in juvenile rheumatoid arthritis. (9503315)
1998
39
Estimates of the discriminant ability of definitions of improvement for juvenile rheumatoid arthritis. (9598903)
1998
40
Identification of childhood arthritis in archaeological material: juvenile rheumatoid arthritis versus juvenile spondyloarthropathy. (9066903)
1997
41
Clinical aspects of juvenile rheumatoid arthritis. (9309197)
1997
42
Polymorphism in the LMP2 gene influences disease susceptibility and severity in HLA-B27 associated juvenile rheumatoid arthritis. (8730138)
1996
43
Vitamin E, thiobarbituric acid reactive substance concentrations and superoxide dismutase activity in the blood of children with juvenile rheumatoid arthritis. (8871845)
1996
44
The use of interferon in the combined therapy of juvenile rheumatoid arthritis]. (1280861)
1992
45
CD5+ B lymphocytes and T-cell subsets in a case of juvenile rheumatoid arthritis. (1376077)
1992
46
Nutritional status and growth in juvenile rheumatoid arthritis. (2251510)
1990
47
IL-6 gene polymorphism in rheumatoid arthritis, pauciarticular juvenile rheumatoid arthritis, systemic lupus erythematosus, and in healthy Danes. (2577114)
1989
48
Cherubism, gingival fibromatosis, epilepsy, and mental deficiency (Ramon syndrome) with juvenile rheumatoid arthritis. (3789007)
1986
49
Reye syndrome and juvenile rheumatoid arthritis in Michigan. (4036917)
1985
50
Progressive pseudorheumatoid arthropathy of childhood (PPAC): a hereditary disorder simulating juvenile rheumatoid arthritis. (6837637)
1983

Genetic Variations for Juvenile Rheumatoid Arthritis

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Expression for genes affiliated with Juvenile Rheumatoid Arthritis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Juvenile Rheumatoid Arthritis

Search GEO for disease gene expression data for Juvenile Rheumatoid Arthritis.

Pathways for genes affiliated with Juvenile Rheumatoid Arthritis

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29KEGG, 53Reactome
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Compounds for genes affiliated with Juvenile Rheumatoid Arthritis

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Sources:
44Novoseek, 59Tocris Bioscience, 49PharmGKB, 11DrugBank, 24HMDB
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Compounds related to Juvenile Rheumatoid Arthritis according to GeneCards/GeneDecks:

(show all 20)
idCompoundScoreTop Affiliating Genes
1pmma4410.8ACP5, IL6, HGF
2pf 04217903 mesylate5910.8HGF, IL6
3su 112745910.8HGF, IL6
4pha 6657525910.7HGF, IL6
5endotoxin4410.7IL6, IL2RB, MIF, C4A, TNXA
6creatinine4410.7HGF, TNXA, MIF, IL2RB, IL6, ACP5
7rebamipide4410.7HGF, IL6
8crizotinib49 5911.7HGF, IL6
9ivig4410.7IL6, IL2RB, S100A12
10steroid4410.7TNXA, C4A, C4B, MIF, CYP21A1P, IL2RB
11alanine4410.6HGF, TNXA, MIF, IL2RB, IL6, TAPBP
12rantes4410.6ACP5, IL6, IL2RB
13polyacrylamide4410.6S100A12, TNXA, MIF, ACP5
14Intravenous Immunoglobulin1110.6C4A, C4B
15thalidomide44 49 59 1113.6IL6, MIF, HGF
16polysaccharide4410.5TAPBP, IL2RB, TNXA, HGF
17serine4410.5IL2RB, MIF
18olopatadine44 1111.5S100A12, IL6
19leukotriene b444 59 2412.3ACP5, IL6, IL2RB
20norepinephrine44 11 2412.2IL2RB

GO Terms for genes affiliated with Juvenile Rheumatoid Arthritis

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16Gene Ontology
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Cellular components related to Juvenile Rheumatoid Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.4HMGB2, IL6, MIF, C4B, C4A, HGF

Biological processes related to Juvenile Rheumatoid Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of apoptotic processGO:04306610.5HMGB2, HGF, PSMB9, MIF, IL2RB, IL6
2monocyte chemotaxisGO:00254810.4IL6, S100A12
3positive chemotaxisGO:05091810.4HMGB2, MIF, HGF
4inflammatory responseGO:00695410.3S100A12, C4A, C4B, MIF, IL6
5positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.2IL6, MIF, HGF

Molecular functions related to Juvenile Rheumatoid Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RAGE receptor bindingGO:05078610.4HMGB2, S100A12
2chemoattractant activityGO:04205610.1HMGB2, MIF, HGF

Products for genes affiliated with Juvenile Rheumatoid Arthritis

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Juvenile Rheumatoid Arthritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet