JIA
MCID: JVN010
MIFTS: 65

Juvenile Rheumatoid Arthritis (JIA) malady

Rare diseases, Respiratory diseases, Bone diseases categories

Summaries for Juvenile Rheumatoid Arthritis

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9Disease Ontology, 22Genetics Home Reference, 35MedlinePlus, 66Wikipedia, 48OMIM, 34MalaCards
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MedlinePlus:35 Juvenile rheumatoid arthritis (jra) is a type of arthritis that happens in children age 16 or younger. it causes joint swelling, pain, stiffness, and loss of motion. it can affect any joint, and in some cases it can affect internal organs as well. one early sign of jra may be limping in the morning. symptoms can come and go. some children have just one or two flare-ups. others have symptoms that never go away. jra causes growth problems in some children. no one knows exactly what causes jra. scientists do know it is an autoimmune disorder, which means your immune system, which normally helps your body fight infection, attacks your body's own tissues. jra can be hard to diagnose. your health care provider may do a physical exam, lab tests, and x-rays. medicines and physical therapy can help maintain movement and reduce swelling and pain. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Juvenile Rheumatoid Arthritis, also known as rheumatoid arthritis, systemic juvenile, is related to arthritis and rheumatoid arthritis, and has symptoms including mediastinal/hilar adenopathies, splenomegaly and arthritis/synovitis/synovial proliferation. An important gene associated with Juvenile Rheumatoid Arthritis is IL6 (interleukin 6 (interferon, beta 2)), and among its related pathways are Immune response MIF mediated glucocorticoid regulation and Rheumatoid arthritis. The compounds pf 04217903 mesylate and su 11274 have been mentioned in the context of this disorder. Affiliated tissues include joint, testes and skin.

Disease Ontology:9 A rheumatoid arthritis that involves an autoimmune disease onset in children under 16 which attacks the healthy cells and tissue of located in joint.

Genetics Home Reference:22 Juvenile idiopathic arthritis refers to a group of conditions involving joint inflammation (arthritis) that first appears before the age of 16. This condition is an autoimmune disorder, which means that the immune system malfunctions and attacks the body's organs and tissues, in this case the joints.

Wikipedia:66 Juvenile idiopathic arthritis (JIA), also known as juvenile rheumatoid arthritis (JRA), is the most... more...

Description from OMIM:48 604302

Aliases & Classifications for Juvenile Rheumatoid Arthritis

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Sources:
9Disease Ontology, 44NIH Rare Diseases, 22Genetics Home Reference, 11DISEASES, 35MedlinePlus, 63UMLS, 48OMIM, 46Novoseek, 50Orphanet, 59SNOMED-CT, 28ICD9CM, 60SNOMED-CT via Orphanet, 27ICD10 via Orphanet, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Respiratory diseases, Bone diseases


Characteristics (Orphanet epidemiological data):

50
systemic-onset juvenile idiopathic arthritis:
Prevalence: 1-9/100000; Age of onset: Childhood; Age of death: Normal


Aliases & Descriptions:

juvenile rheumatoid arthritis 9 44 22 11 35
rheumatoid arthritis, systemic juvenile 48 46 63
arthritis, juvenile rheumatoid 44 22 63
juvenile idiopathic arthritis 9 44 22
monarticular juvenile rheumatoid arthritis 9 63
juvenile chronic polyarthritis 9 63
juvenile chronic arthritis 44 22
acute polyarticular juvenile rheumatoid arthritis 63
pauciarticular onset juvenile chronic arthritis 9
systemic-onset juvenile idiopathic arthritis 50
systemic juvenile rheumatoid arthritis 22
acute juvenile rheumatoid arthritis 9
pauciarticular juvenile arthritis 9
arthritis juvenile rheumatoid 46
juvenile-onset still disease 63
systemic polyarthritis 50
juvenile arthritis 44
still disease 50
juvenile ra 22
jra 22
jia 22


External Ids:

Disease Ontology9 DOID:676
ICD9CM28 714.31
SNOMED-CT via Orphanet60 201796004, 410794002
OMIM48 604302
ICD10 via Orphanet27 M08.2

Related Diseases for Juvenile Rheumatoid Arthritis

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Rheumatoid Arthritis family:

juvenile rheumatoid arthritis

Diseases related to Juvenile Rheumatoid Arthritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 231)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis32.3S100A12, IL6, ACP5, MIF
2rheumatoid arthritis32.2HLA-DRB4, FCRL3, MIF, ACP5, IL6, S100A12
3lupus erythematosus31.2C4A
4systemic lupus erythematosus31.2C4A
5osteoporosis30.3IL6, ACP5, TNXA
6inflammatory bowel disease30.2S100A12, IL6, MIF
7sepsis30.1MIF, IL6, C4A
8iridocyclitis10.8
9uveitis10.8
10enthesitis-related arthritis10.8
11macrophage activation syndrome10.6
12anterior uveitis10.6
13spondyloarthropathy10.6
14synovitis10.6
15pauciarticular onset juvenile idiopathic arthritis10.6
16arthropathy10.5
17leukemia10.5
18periodontitis10.5
19enthesitis-related juvenile idiopathic arthritis10.5
20psoriatic juvenile idiopathic arthritis10.5
21vasculitis10.5
22iritis10.4
23cerebritis10.4
24psoriatic arthritis10.4
25amyloidosis10.4
26asthma10.4
27cataract10.4
28dermatomyositis10.4
29glaucoma10.4
30lymphoblastic leukemia10.4
31polyarticular onset juvenile idiopathic arthritis10.4
32progressive pseudorheumatoid arthropathy of childhood10.4
33rubella10.4
34aggressive periodontitis10.4
35bronchiolitis10.3
36bronchiolitis obliterans10.3
37childhood leukemia10.3
38hepatitis10.3
39hodgkin's lymphoma10.3
40pneumonia10.3
41sarcoidosis10.3
42sickle cell disease10.3
43spondylarthropathy10.3
44blindness10.3
45crohn's disease10.3
46cardiac tamponade10.3
47familial mediterranean fever10.3
48reactive arthritis10.3
49measles10.3
50mumps10.3

Graphical network of the top 20 diseases related to Juvenile Rheumatoid Arthritis:



Diseases related to juvenile rheumatoid arthritis

Symptoms for Juvenile Rheumatoid Arthritis

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Sources:
48OMIM, 50Orphanet
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Clinical features from OMIM:

604302

Symptoms:

50 (show all 13)
  • mediastinal/hilar adenopathies
  • splenomegaly
  • arthritis/synovitis/synovial proliferation
  • fever/chilling
  • articular/joint pain/arthralgia
  • hydrarthrosis/articular/joint effusion
  • cutaneous rash
  • autoimmunity/autoimmune reaction/autoantibodies
  • acute abdominal pain/colic
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • hepatomegaly/liver enlargement (excluding storage disease)

Drugs & Therapeutics for Juvenile Rheumatoid Arthritis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Juvenile Rheumatoid Arthritis

Drug clinical trials:

Search ClinicalTrials for Juvenile Rheumatoid Arthritis

Search NIH Clinical Center for Juvenile Rheumatoid Arthritis

Search CenterWatch for Juvenile Rheumatoid Arthritis

Genetic Tests for Juvenile Rheumatoid Arthritis

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Anatomical Context for Juvenile Rheumatoid Arthritis

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34MalaCards, 15FMA
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MalaCards organs/tissues related to Juvenile Rheumatoid Arthritis:

34
Testes, Skin, Bone, T cells, Liver, Myeloid, Monocytes, B cells, Eye, Breast, Lung, Kidney, Endothelial, Thyroid, Retina

FMA organs/tissues related to Juvenile Rheumatoid Arthritis:

15
Joint

Animal Models for Juvenile Rheumatoid Arthritis or affiliated genes

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Publications for Juvenile Rheumatoid Arthritis

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53PubMed
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Articles related to Juvenile Rheumatoid Arthritis:

(show top 50)    (show all 572)
idTitleAuthorsYear
1
Dental surgery and anesthetic precautions of a patient with Down syndrome and juvenile rheumatoid arthritis: a case report. (23265174)
2012
2
Sexual maturation in boys with juvenile rheumatoid arthritis. (20429008)
2011
3
Hypersensitive joint reaction after etanercept treatment in a patient with juvenile rheumatoid arthritis. (21362794)
2011
4
Acute lymphoblastic leukemia masquerading as juvenile rheumatoid arthritis: diagnostic pitfall and association with survival. (19727722)
2010
5
Type 1 diabetes associated with Hashimoto's thyroiditis and juvenile rheumatoid arthritis: a case report with clinical and genetic investigations. (21118342)
2010
6
Biochemical markers of bone turnover associated with calcium supplementation in children with juvenile rheumatoid arthritis: results of a double-blind, placebo-controlled intervention trial. (19035501)
2008
7
Trials reveal promising options for treating juvenile rheumatoid arthritis. (18167400)
2008
8
Adalimumab in juvenile rheumatoid arthritis. (19052133)
2008
9
Synovectomy of the hip in patients with juvenile rheumatoid arthritis. (17768196)
2007
10
Serum melatonin in juvenile rheumatoid arthritis: correlation with disease activity. (19069959)
2007
11
Improving adherence to medical regimens for juvenile rheumatoid arthritis. (17550635)
2007
12
Increased Fas and Bcl-2 expression on peripheral blood T and B lymphocytes from juvenile-onset systemic lupus erythematosus, but not from juvenile rheumatoid arthritis and juvenile dermatomyositis. (17162369)
2006
13
A randomized controlled trial of calcium supplementation to increase bone mineral density in children with juvenile rheumatoid arthritis. (16802360)
2006
14
Etanercept therapy in children with juvenile rheumatoid arthritis. (16341346)
2005
15
Novel approaches to gene expression analysis of active polyarticular juvenile rheumatoid arthritis. (14979934)
2004
16
Another patient with chromosome 18 deletion syndrome and juvenile rheumatoid arthritis. (15124264)
2004
17
Effective use of the recombinant interleukin 1 receptor antagonist anakinra in therapy resistant systemic onset juvenile rheumatoid arthritis. (15468378)
2004
18
Favorable outcome in patients with renal involvement complicating macrophage activation syndrome in systemic onset juvenile rheumatoid arthritis. (15468377)
2004
19
Comparing the self-reported referral and management preferences of pediatricians and family physicians for children with juvenile rheumatoid arthritis. (14719216)
2003
20
Brief report: adjustment to juvenile rheumatoid arthritis: a family systems perspective. (12808011)
2003
21
A controlled longitudinal study of the social functioning of children with juvenile rheumatoid arthritis. (12490627)
2003
22
The significance of elevated serologic markers of celiac disease in children with juvenile rheumatoid arthritis. (19861810)
2003
23
Elbow synovectomy on patients with juvenile rheumatoid arthritis. (12838054)
2003
24
Growth patterns in juvenile rheumatoid arthritis. (14611121)
2003
25
Methotrexate inhibits interleukin-6 production in patients with juvenile rheumatoid arthritis. (12739045)
2003
26
Polymorphism of human HLA-DRB1 leukocyte antigen alleles and its association to juvenile rheumatoid arthritis in a sample of Colombian mestizo children]. (14582328)
2003
27
High response rate in the phase I/II study of meloxicam in juvenile rheumatoid arthritis. (12022326)
2002
28
Etanercept: an updated review of its use in rheumatoid arthritis, psoriatic arthritis and juvenile rheumatoid arthritis. (12421111)
2002
29
The prevalence of uveitis in juvenile rheumatoid arthritis. (11182663)
2001
30
Antioxidant enzymes levels in children with juvenile rheumatoid arthritis. (12092181)
2001
31
What's new in the diagnosis and treatment of juvenile rheumatoid arthritis. (10912594)
2000
32
Interleukin 8 and monocyte chemoattractant protein-1 in patients with juvenile rheumatoid arthritis. Relation to onset types, disease activity, and synovial fluid leukocytes. (9972980)
1999
33
Juvenile rheumatoid arthritis. (10503657)
1999
34
On beyond methotrexate treatment of severe juvenile rheumatoid arthritis. (10464566)
1999
35
Clinical relevance of IgA rheumatoid factor (RF) in children with juvenile rheumatoid arthritis. (10651082)
1999
36
Pharmacokinetics of etodolac in patients with stable juvenile rheumatoid arthritis. (10566567)
1999
37
Psychological symptoms in chronic fatigue and juvenile rheumatoid arthritis. (10224175)
1999
38
Juvenile rheumatoid arthritis in a Canadian First Nations (aboriginal) population: onset subtypes and HLA associations. (9558186)
1998
39
Juvenile rheumatoid arthritis and common variable hypogammaglobulinemia. (9632087)
1998
40
Felty syndrome complicating juvenile rheumatoid arthritis. (9787332)
1998
41
Transmission disequilibrium as a test of linkage and association between HLA alleles and pauciarticular-onset juvenile rheumatoid arthritis. (9751094)
1998
42
Juvenile rheumatoid arthritis: ethnic differences in diagnostic types. (9292786)
1997
43
Polymorphism in the LMP2 gene influences disease susceptibility and severity in HLA-B27 associated juvenile rheumatoid arthritis. (8730138)
1996
44
Elevated circulating interleukin-7 levels in patients with systemic juvenile rheumatoid arthritis. (7473488)
1995
45
Cytokine levels in serum and synovial fluid of patients with juvenile rheumatoid arthritis. (7699643)
1994
46
A novel autoantibody to the putative oncoprotein DEK in pauciarticular onset juvenile rheumatoid arthritis. (7869324)
1994
47
Intravenous immunoglobulin in the treatment of systemic juvenile rheumatoid arthritis: a randomized placebo controlled trial. Pediatric Rheumatology Collaborative Study Group. (7699642)
1994
48
Reye syndrome and juvenile rheumatoid arthritis in Michigan. (4036917)
1985
49
Iridocyclitis and pauciarticular juvenile rheumatoid arthritis. (5104123)
1971
50
Chronic iridocyclitis in juvenile rheumatoid arthritis. (5310717)
1970

Variations for Juvenile Rheumatoid Arthritis

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Expression for genes affiliated with Juvenile Rheumatoid Arthritis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Juvenile Rheumatoid Arthritis

Search GEO for disease gene expression data for Juvenile Rheumatoid Arthritis.

Pathways for genes affiliated with Juvenile Rheumatoid Arthritis

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Sources:
51PathCards, 61Thomson Reuters, 31KEGG, 39NCBI BioSystems Database, 54QIAGEN
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Compounds for genes affiliated with Juvenile Rheumatoid Arthritis

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Sources:
62Tocris Bioscience, 46Novoseek, 12DrugBank, 52PharmGKB, 3BitterDB, 30IUPHAR, 25HMDB
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Compounds related to Juvenile Rheumatoid Arthritis according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1pf 04217903 mesylate6210.4IL6, HGF
2su 112746210.4IL6, HGF
3pha 6657526210.4IL6, HGF
4rebamipide4610.4HGF, IL6
5filgrastim46 1211.3IL6, HGF
6crizotinib62 5211.3IL6, HGF
7thalidomide46 52 62 1213.2MIF, IL6, HGF
8hydrocortisone46 3 62 1213.1HGF, IL6, MIF
9clodronate46 52 1212.1IL6, ACP5
10pmma4610.1HGF, IL6, ACP5
11olopatadine46 1211.1S100A12, IL6
12herbimycin a46 6211.0HGF, IL6, MIF
13anaphylatoxin469.8C4A, IL6
14pge2469.8HGF, IL6, ACP5, MIF
15rantes469.7IL6, ACP5, MIF
16lactate469.7IGES, MIF, IL6, HGF
17cyclosporin a46 30 6211.6IGES, ACP5, IL6, HGF
18endotoxin469.3TNXA, MIF, IL6, C4A
19estrogen469.2MIF, ACP5, IL6, HGF, HMGB2
20copper46 2510.1TNXA, HGF, S100A12
21creatinine469.0HGF, IL6, ACP5, MIF, TNXA
22aspirin46 52 30 2512.0IGES, TNXA, HGF
23polyacrylamide469.0TNXA, MIF, ACP5, S100A12
24h2o2468.9HGF, ACP5, MIF, TNXA
25heparin46 30 25 1211.9TNXA, ACP5, HGF, C4B
26tyrosine468.7SH2D2A, MIF, ACP5, IL6, HGF, TRO
27lipid468.4TNXA, MIF, ACP5, IL6, HGF
28serine468.4CYP21A1P, TNXA, MIF, HGF, C4A, C4B
29steroid468.2IGES, CYP21A1P, TNXA, MIF, C4A, C4B

GO Terms for genes affiliated with Juvenile Rheumatoid Arthritis

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17Gene Ontology
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Cellular components related to Juvenile Rheumatoid Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.6C4B, C4A, S100A12, HGF, IL6, MIF

Biological processes related to Juvenile Rheumatoid Arthritis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.0HGF, IL6, MIF
2monocyte chemotaxisGO:0025489.9IL6, S100A12
3negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:19020429.8HMGB2, HGF
4negative regulation of tumor necrosis factor productionGO:0327209.8ACP5, NFKBIL1
5regulation of complement activationGO:0304499.8C4B, C4A
6positive chemotaxisGO:0509189.7MIF, HGF, HMGB2
7defense response to Gram-positive bacteriumGO:0508309.6IL6, ACP5
8innate immune responseGO:0450879.0C4B, C4A, S100A12, MIF
9inflammatory responseGO:0069549.0C4B, C4A, S100A12, IL6, MIF

Molecular functions related to Juvenile Rheumatoid Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endopeptidase inhibitor activityGO:0048669.8C4B, C4A
2chemoattractant activityGO:0420569.4HMGB2, HGF, MIF
3RAGE receptor bindingGO:0507869.1HMGB2, S100A12

Products for genes affiliated with Juvenile Rheumatoid Arthritis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Juvenile Rheumatoid Arthritis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet