JIA
MCID: JVN010
MIFTS: 66

Juvenile Rheumatoid Arthritis (JIA) malady

Rare diseases, Respiratory diseases, Bone diseases categories
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Summaries for Juvenile Rheumatoid Arthritis

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MedlinePlus:33 Juvenile rheumatoid arthritis (jra) is a type of arthritis that happens in children age 16 or younger. it causes joint swelling, pain, stiffness, and loss of motion. it can affect any joint, and in some cases it can affect internal organs as well. one early sign of jra may be limping in the morning. symptoms can come and go. some children have just one or two flare-ups. others have symptoms that never go away. jra causes growth problems in some children. no one knows exactly what causes jra. scientists do know it is an autoimmune disorder, which means your immune system, which normally helps your body fight infection, attacks your body's own tissues. jra can be hard to diagnose. your health care provider may do a physical exam, lab tests, and x-rays. medicines and physical therapy can help maintain movement and reduce swelling and pain. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards based summary: Juvenile Rheumatoid Arthritis, also known as rheumatoid arthritis, systemic juvenile, is related to arthritis and rheumatoid arthritis, and has symptoms including cutaneous rash, articular/joint pain/arthralgia and hydrarthrosis/articular/joint effusion. An important gene associated with Juvenile Rheumatoid Arthritis is IL6 (interleukin 6 (interferon, beta 2)), and among its related pathways are Immune response MIF mediated glucocorticoid regulation and Rheumatoid arthritis. The compounds pf 04217903 mesylate and su 11274 have been mentioned in the context of this disorder. Affiliated tissues include joint, testes and skin.

Disease Ontology:8 A rheumatoid arthritis that involves an autoimmune disease onset in children under 16 which attacks the healthy cells and tissue of located in joint.

Genetics Home Reference:21 Juvenile idiopathic arthritis refers to a group of conditions involving joint inflammation (arthritis) that first appears before the age of 16. This condition is an autoimmune disorder, which means that the immune system malfunctions and attacks the body's organs and tissues, in this case the joints.

Wikipedia:65 Juvenile idiopathic arthritis (JIA), also known as juvenile rheumatoid arthritis (JRA), is the most... more...

Description from OMIM:46 604302

Aliases & Classifications for Juvenile Rheumatoid Arthritis

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Juvenile Rheumatoid Arthritis, Aliases & Descriptions:

Name: Juvenile Rheumatoid Arthritis 8 42 21 10 33
Rheumatoid Arthritis, Systemic Juvenile 46 44 62
Arthritis, Juvenile Rheumatoid 42 21 62
Juvenile Idiopathic Arthritis 8 42 21
Pauciarticular Onset Juvenile Chronic Arthritis 8 62
Monarticular Juvenile Rheumatoid Arthritis 8 62
Juvenile Chronic Polyarthritis 8 62
Juvenile Chronic Arthritis 42 21
Acute Polyarticular Juvenile Rheumatoid Arthritis 62
Systemic-Onset Juvenile Idiopathic Arthritis 48
Systemic Juvenile Rheumatoid Arthritis 21
 
Acute Juvenile Rheumatoid Arthritis 8
Pauciarticular Juvenile Arthritis 8
Arthritis Juvenile Rheumatoid 44
Juvenile-Onset Still Disease 62
Systemic Polyarthritis 48
Juvenile Arthritis 42
Still Disease 48
Juvenile Ra 21
Jra 21
Jia 21


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Respiratory diseases, Bone diseases


Characteristics (Orphanet epidemiological data):

48
systemic-onset juvenile idiopathic arthritis:
Prevalence: 1-9/100000; Age of onset: Childhood; Age of death: Normal


External Ids:

Disease Ontology8 DOID:676
ICD9CM27 714.31
OMIM46 604302
ICD10 via Orphanet26 M08.2

Related Diseases for Juvenile Rheumatoid Arthritis

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Diseases in the Rheumatoid Arthritis family:

juvenile rheumatoid arthritis

Diseases related to Juvenile Rheumatoid Arthritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 236)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis32.1ACP5, MIF, S100A12, IL6
2rheumatoid arthritis31.7HLA-DRB4, FCRL3, MIF, S100A12, IL6, ACP5
3lupus erythematosus31.6C4A
4systemic lupus erythematosus31.6C4A
5osteoporosis30.5IL6, ACP5, TNXA
6inflammatory bowel disease30.2MIF, IL6, S100A12
7sepsis30.0C4A, MIF, IL6
8iridocyclitis10.8
9uveitis10.8
10enthesitis-related arthritis10.8
11anterior uveitis10.7
12macrophage activation syndrome10.6
13spondyloarthropathy10.6
14synovitis10.6
15pauciarticular onset juvenile idiopathic arthritis10.6
16leukemia10.5
17arthropathy10.5
18crohn disease-associated growth failure10.5IL6
19periodontitis10.5
20enthesitis-related juvenile idiopathic arthritis10.5
21psoriatic juvenile idiopathic arthritis10.5
22vasculitis10.5
23acute lymphoblastic leukemia10.4
24asthma10.4
25cataract10.4
26iritis10.4
27psoriatic arthritis10.4
28cerebritis10.4
29amyloidosis10.4
30dermatomyositis10.4
31lymphoblastic leukemia10.4
32polyarticular onset juvenile idiopathic arthritis10.4
33progressive pseudorheumatoid arthropathy of childhood10.4
34blindness10.4
35autosomal dominant hyper ige syndrome10.4IL6, IGES
36aggressive periodontitis10.4
37rubella10.4
38chorioamnionitis10.4IL6, S100A12
39bronchiolitis obliterans10.3
40hepatitis10.3
41hodgkin's lymphoma10.3
42bronchiolitis10.3
43childhood leukemia10.3
44pneumonia10.3
45sarcoidosis10.3
46sickle cell disease10.3
47spondylarthropathy10.3
48systemic onset juvenile idiopathic arthritis10.3
49rheumatic disease10.3
50common variable immunodeficiency10.3

Graphical network of the top 20 diseases related to Juvenile Rheumatoid Arthritis:



Diseases related to juvenile rheumatoid arthritis

Symptoms for Juvenile Rheumatoid Arthritis

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Clinical features from OMIM:

604302

Symptoms:

48 (show all 13)
  • cutaneous rash
  • articular/joint pain/arthralgia
  • hydrarthrosis/articular/joint effusion
  • arthritis/synovitis/synovial proliferation
  • autoimmunity/autoimmune reaction/autoantibodies
  • fever/chilling
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • mediastinal/hilar adenopathies
  • acute abdominal pain/colic
  • hepatomegaly/liver enlargement (excluding storage disease)
  • splenomegaly
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion

HPO human phenotypes related to Juvenile Rheumatoid Arthritis:

(show all 35)
id Description Frequency HPO Source Accession
1 skin rash hallmark (90%) HP:0000988
2 arthritis hallmark (90%) HP:0001369
3 joint swelling hallmark (90%) HP:0001386
4 arthralgia hallmark (90%) HP:0002829
5 autoimmunity hallmark (90%) HP:0002960
6 abnormality of temperature regulation hallmark (90%) HP:0004370
7 arthritis hallmark (90%) HP:0001369
8 arthralgia hallmark (90%) HP:0002829
9 autoimmunity hallmark (90%) HP:0002960
10 abnormality of temperature regulation hallmark (90%) HP:0004370
11 abnormal tendon morphology hallmark (90%) HP:0100261
12 mediastinal lymphadenopathy typical (50%) HP:0100721
13 abnormality of the urethra typical (50%) HP:0000795
14 hyperkeratosis typical (50%) HP:0000962
15 skin rash typical (50%) HP:0000988
16 abnormality of the fingernails typical (50%) HP:0001231
17 joint dislocation typical (50%) HP:0001373
18 limitation of joint mobility typical (50%) HP:0001376
19 joint swelling typical (50%) HP:0001386
20 malabsorption typical (50%) HP:0002024
21 abdominal pain typical (50%) HP:0002027
22 abnormality of the pleura typical (50%) HP:0002103
23 psoriasis typical (50%) HP:0003765
24 inflammatory abnormality of the eye typical (50%) HP:0100533
25 mediastinal lymphadenopathy typical (50%) HP:0100721
26 cartilage destruction typical (50%) HP:0100773
27 abnormality of the sacroiliac joint typical (50%) HP:0100781
28 abnormality of the pericardium occasional (7.5%) HP:0001697
29 splenomegaly occasional (7.5%) HP:0001744
30 abdominal pain occasional (7.5%) HP:0002027
31 abnormality of the pleura occasional (7.5%) HP:0002103
32 hepatomegaly occasional (7.5%) HP:0002240
33 abnormality of the pericardium occasional (7.5%) HP:0001697
34 splenomegaly occasional (7.5%) HP:0001744
35 hepatomegaly occasional (7.5%) HP:0002240

Drugs & Therapeutics for Juvenile Rheumatoid Arthritis

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Drug clinical trials:

Search ClinicalTrials for Juvenile Rheumatoid Arthritis

Search NIH Clinical Center for Juvenile Rheumatoid Arthritis

Genetic Tests for Juvenile Rheumatoid Arthritis

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Anatomical Context for Juvenile Rheumatoid Arthritis

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MalaCards organs/tissues related to Juvenile Rheumatoid Arthritis:

32
Testes, Skin, Bone, T cells, Liver, Myeloid, Neutrophil, Eye, Monocytes, B cells, Retina, Kidney, Lung, Thyroid, Breast, Endothelial

FMA organs/tissues related to Juvenile Rheumatoid Arthritis:

14
Joint

Animal Models for Juvenile Rheumatoid Arthritis or affiliated genes

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Publications for Juvenile Rheumatoid Arthritis

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Articles related to Juvenile Rheumatoid Arthritis:

(show top 50)    (show all 576)
idTitleAuthorsYear
1
Dental surgery and anesthetic precautions of a patient with Down syndrome and juvenile rheumatoid arthritis: a case report. (23265174)
2012
2
Sexual maturation in boys with juvenile rheumatoid arthritis. (20429008)
2011
3
Hypersensitive joint reaction after etanercept treatment in a patient with juvenile rheumatoid arthritis. (21362794)
2011
4
Acute lymphoblastic leukemia masquerading as juvenile rheumatoid arthritis: diagnostic pitfall and association with survival. (19727722)
2010
5
Type 1 diabetes associated with Hashimoto's thyroiditis and juvenile rheumatoid arthritis: a case report with clinical and genetic investigations. (21118342)
2010
6
Biochemical markers of bone turnover associated with calcium supplementation in children with juvenile rheumatoid arthritis: results of a double-blind, placebo-controlled intervention trial. (19035501)
2008
7
Trials reveal promising options for treating juvenile rheumatoid arthritis. (18167400)
2008
8
Adalimumab in juvenile rheumatoid arthritis. (19052133)
2008
9
Synovectomy of the hip in patients with juvenile rheumatoid arthritis. (17768196)
2007
10
Serum melatonin in juvenile rheumatoid arthritis: correlation with disease activity. (19069959)
2007
11
Improving adherence to medical regimens for juvenile rheumatoid arthritis. (17550635)
2007
12
Increased Fas and Bcl-2 expression on peripheral blood T and B lymphocytes from juvenile-onset systemic lupus erythematosus, but not from juvenile rheumatoid arthritis and juvenile dermatomyositis. (17162369)
2006
13
A randomized controlled trial of calcium supplementation to increase bone mineral density in children with juvenile rheumatoid arthritis. (16802360)
2006
14
Etanercept therapy in children with juvenile rheumatoid arthritis. (16341346)
2005
15
Novel approaches to gene expression analysis of active polyarticular juvenile rheumatoid arthritis. (14979934)
2004
16
Another patient with chromosome 18 deletion syndrome and juvenile rheumatoid arthritis. (15124264)
2004
17
Effective use of the recombinant interleukin 1 receptor antagonist anakinra in therapy resistant systemic onset juvenile rheumatoid arthritis. (15468378)
2004
18
Favorable outcome in patients with renal involvement complicating macrophage activation syndrome in systemic onset juvenile rheumatoid arthritis. (15468377)
2004
19
Comparing the self-reported referral and management preferences of pediatricians and family physicians for children with juvenile rheumatoid arthritis. (14719216)
2003
20
Brief report: adjustment to juvenile rheumatoid arthritis: a family systems perspective. (12808011)
2003
21
A controlled longitudinal study of the social functioning of children with juvenile rheumatoid arthritis. (12490627)
2003
22
The significance of elevated serologic markers of celiac disease in children with juvenile rheumatoid arthritis. (19861810)
2003
23
Elbow synovectomy on patients with juvenile rheumatoid arthritis. (12838054)
2003
24
Growth patterns in juvenile rheumatoid arthritis. (14611121)
2003
25
Methotrexate inhibits interleukin-6 production in patients with juvenile rheumatoid arthritis. (12739045)
2003
26
Polymorphism of human HLA-DRB1 leukocyte antigen alleles and its association to juvenile rheumatoid arthritis in a sample of Colombian mestizo children]. (14582328)
2003
27
High response rate in the phase I/II study of meloxicam in juvenile rheumatoid arthritis. (12022326)
2002
28
Etanercept: an updated review of its use in rheumatoid arthritis, psoriatic arthritis and juvenile rheumatoid arthritis. (12421111)
2002
29
The prevalence of uveitis in juvenile rheumatoid arthritis. (11182663)
2001
30
Antioxidant enzymes levels in children with juvenile rheumatoid arthritis. (12092181)
2001
31
What's new in the diagnosis and treatment of juvenile rheumatoid arthritis. (10912594)
2000
32
Interleukin 8 and monocyte chemoattractant protein-1 in patients with juvenile rheumatoid arthritis. Relation to onset types, disease activity, and synovial fluid leukocytes. (9972980)
1999
33
Juvenile rheumatoid arthritis. (10503657)
1999
34
On beyond methotrexate treatment of severe juvenile rheumatoid arthritis. (10464566)
1999
35
Clinical relevance of IgA rheumatoid factor (RF) in children with juvenile rheumatoid arthritis. (10651082)
1999
36
Pharmacokinetics of etodolac in patients with stable juvenile rheumatoid arthritis. (10566567)
1999
37
Psychological symptoms in chronic fatigue and juvenile rheumatoid arthritis. (10224175)
1999
38
Juvenile rheumatoid arthritis in a Canadian First Nations (aboriginal) population: onset subtypes and HLA associations. (9558186)
1998
39
Juvenile rheumatoid arthritis and common variable hypogammaglobulinemia. (9632087)
1998
40
Felty syndrome complicating juvenile rheumatoid arthritis. (9787332)
1998
41
Transmission disequilibrium as a test of linkage and association between HLA alleles and pauciarticular-onset juvenile rheumatoid arthritis. (9751094)
1998
42
Juvenile rheumatoid arthritis: ethnic differences in diagnostic types. (9292786)
1997
43
Polymorphism in the LMP2 gene influences disease susceptibility and severity in HLA-B27 associated juvenile rheumatoid arthritis. (8730138)
1996
44
Elevated circulating interleukin-7 levels in patients with systemic juvenile rheumatoid arthritis. (7473488)
1995
45
Cytokine levels in serum and synovial fluid of patients with juvenile rheumatoid arthritis. (7699643)
1994
46
A novel autoantibody to the putative oncoprotein DEK in pauciarticular onset juvenile rheumatoid arthritis. (7869324)
1994
47
Intravenous immunoglobulin in the treatment of systemic juvenile rheumatoid arthritis: a randomized placebo controlled trial. Pediatric Rheumatology Collaborative Study Group. (7699642)
1994
48
Reye syndrome and juvenile rheumatoid arthritis in Michigan. (4036917)
1985
49
Iridocyclitis and pauciarticular juvenile rheumatoid arthritis. (5104123)
1971
50
Chronic iridocyclitis in juvenile rheumatoid arthritis. (5310717)
1970

Variations for Juvenile Rheumatoid Arthritis

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Expression for genes affiliated with Juvenile Rheumatoid Arthritis

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Expression patterns in normal tissues for genes affiliated with Juvenile Rheumatoid Arthritis

Search GEO for disease gene expression data for Juvenile Rheumatoid Arthritis.

Pathways for genes affiliated with Juvenile Rheumatoid Arthritis

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Compounds for genes affiliated with Juvenile Rheumatoid Arthritis

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Compounds related to Juvenile Rheumatoid Arthritis according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1pf 04217903 mesylate6110.4IL6, HGF
2su 112746110.4IL6, HGF
3pha 6657526110.4IL6, HGF
4rebamipide4410.4HGF, IL6
5filgrastim44 1111.3IL6, HGF
6crizotinib61 5011.3IL6, HGF
7thalidomide44 50 61 1113.2MIF, IL6, HGF
8hydrocortisone44 2 61 1113.1HGF, IL6, MIF
9clodronate44 50 1112.1IL6, ACP5
10pmma4410.1HGF, IL6, ACP5
11olopatadine44 1111.1S100A12, IL6
12herbimycin a44 6111.0HGF, IL6, MIF
13anaphylatoxin449.8C4A, IL6
14pge2449.8HGF, IL6, ACP5, MIF
15rantes449.7IL6, ACP5, MIF
16lactate449.7IGES, MIF, IL6, HGF
17cyclosporin a44 28 6111.6IGES, ACP5, IL6, HGF
18endotoxin449.3TNXA, MIF, IL6, C4A
19estrogen449.2MIF, ACP5, IL6, HGF, HMGB2
20copper44 2410.1TNXA, HGF, S100A12
21creatinine449.0HGF, IL6, ACP5, MIF, TNXA
22aspirin44 50 28 2412.0IGES, TNXA, HGF
23polyacrylamide449.0TNXA, MIF, ACP5, S100A12
24h2o2448.9HGF, ACP5, MIF, TNXA
25heparin44 28 24 1111.9TNXA, ACP5, HGF, C4B
26tyrosine448.7SH2D2A, MIF, ACP5, IL6, HGF, TRO
27lipid448.4TNXA, MIF, ACP5, IL6, HGF
28serine448.4CYP21A1P, TNXA, MIF, HGF, C4A, C4B
29steroid448.2IGES, CYP21A1P, TNXA, MIF, C4A, C4B

GO Terms for genes affiliated with Juvenile Rheumatoid Arthritis

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Cellular components related to Juvenile Rheumatoid Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.6C4B, C4A, S100A12, HGF, IL6, MIF

Biological processes related to Juvenile Rheumatoid Arthritis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.0HGF, IL6, MIF
2monocyte chemotaxisGO:0025489.9IL6, S100A12
3negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:19020429.8HMGB2, HGF
4negative regulation of tumor necrosis factor productionGO:0327209.8ACP5, NFKBIL1
5regulation of complement activationGO:0304499.8C4B, C4A
6positive chemotaxisGO:0509189.7MIF, HGF, HMGB2
7defense response to Gram-positive bacteriumGO:0508309.6IL6, ACP5
8innate immune responseGO:0450879.0C4B, C4A, S100A12, MIF
9inflammatory responseGO:0069549.0C4B, C4A, S100A12, IL6, MIF

Molecular functions related to Juvenile Rheumatoid Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endopeptidase inhibitor activityGO:0048669.8C4B, C4A
2chemoattractant activityGO:0420569.4HMGB2, HGF, MIF
3RAGE receptor bindingGO:0507869.1HMGB2, S100A12

Products for genes affiliated with Juvenile Rheumatoid Arthritis

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  • Antibodies
  • Proteins
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Sources for Juvenile Rheumatoid Arthritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet