JIA
MCID: JVN010
MIFTS: 67

Juvenile Rheumatoid Arthritis (JIA) malady

Respiratory diseases, Bone diseases categories

Summaries for Juvenile Rheumatoid Arthritis

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8Disease Ontology, 21Genetics Home Reference, 33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Juvenile rheumatoid arthritis (jra) is a type of arthritis that happens in children age 16 or younger. it causes joint swelling, pain, stiffness, and loss of motion. it can affect any joint, and in some cases it can affect internal organs as well. one early sign of jra may be limping in the morning. symptoms can come and go. some children have just one or two flare-ups. others have symptoms that never go away. jra causes growth problems in some children. no one knows exactly what causes jra. scientists do know it is an autoimmune disorder, which means your immune system, which normally helps your body fight infection, attacks your body's own tissues. jra can be hard to diagnose. your health care provider may do a physical exam, lab tests, and x-rays. medicines and physical therapy can help maintain movement and reduce swelling and pain. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Juvenile Rheumatoid Arthritis, also known as rheumatoid arthritis, systemic juvenile, is related to arthritis and rheumatoid arthritis, and has symptoms including splenomegaly, arthritis/synovitis/synovial proliferation and fever/chilling. An important gene associated with Juvenile Rheumatoid Arthritis is IL6 (interleukin 6 (interferon, beta 2)), and among its related pathways are Rheumatoid arthritis and Interleukin-3, 5 and GM-CSF signaling. The compounds pmma and pf 04217903 mesylate have been mentioned in the context of this disorder. Affiliated tissues include joint, testes and skin, and related mouse phenotype hematopoietic system.

Disease Ontology:8 A rheumatoid arthritis that involves an autoimmune disease onset in children under 16 which attacks the healthy cells and tissue of located in joint.

Genetics Home Reference:21 Juvenile idiopathic arthritis refers to a group of conditions involving joint inflammation (arthritis) that first appears before the age of 16. This condition is an autoimmune disorder, which means that the immune system malfunctions and attacks the body's organs and tissues, in this case the joints.

Wikipedia:63 Juvenile idiopathic arthritis (JIA), also known as juvenile rheumatoid arthritis (JRA), is the most... more...

Description from OMIM:46 604302

Aliases & Classifications for Juvenile Rheumatoid Arthritis

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8Disease Ontology, 42NIH Rare Diseases, 21Genetics Home Reference, 46OMIM, 10DISEASES, 44Novoseek, 48Orphanet, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 27ICD9CM, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases, Bone diseases


Characteristics (Orphanet epidemiological data):

48
systemic-onset juvenile idiopathic arthritis:
Prevalence: 1-9/100000; Age of onset: Childhood; Age of death: Normal


Aliases & Descriptions:

juvenile rheumatoid arthritis 8 42 21 10 33
rheumatoid arthritis, systemic juvenile 46 44 60
arthritis, juvenile rheumatoid 42 21 60
juvenile idiopathic arthritis 8 42 21
monarticular juvenile rheumatoid arthritis 8 60
juvenile chronic polyarthritis 8 60
juvenile chronic arthritis 42 21
acute polyarticular juvenile rheumatoid arthritis 60
pauciarticular onset juvenile chronic arthritis 8
systemic-onset juvenile idiopathic arthritis 48
systemic juvenile rheumatoid arthritis 21
acute juvenile rheumatoid arthritis 8
pauciarticular juvenile arthritis 8
arthritis juvenile rheumatoid 44
juvenile-onset still disease 60
systemic polyarthritis 48
juvenile arthritis 42
still disease 48
juvenile ra 21
jra 21
jia 21


External Ids:

Disease Ontology8 DOID:676
ICD9CM27 714.31
SNOMED-CT via Orphanet57 201796004, 410794002
OMIM46 604302
ICD10 via Orphanet26 M08.2

Related Diseases for Juvenile Rheumatoid Arthritis

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Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Rheumatoid Arthritis family:

juvenile rheumatoid arthritis

Diseases related to Juvenile Rheumatoid Arthritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 218)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis32.3ACP5, S100A12, PSMB9, MIF, IL2RB, IL6
2rheumatoid arthritis32.3S100A12, HLA-DRB4, MIF, IL2RB, IL6, ACP5
3lupus erythematosus31.0C4A
4systemic lupus erythematosus31.0C4B, DEK, MIF, CYP21A1P, IL2RB, IL6
5synovitis30.8IL6
6leukemia30.7DEK, MAGEA1, IL2RB, IL6, ACP5
7asthma30.5S100A12, MIF
8sarcoidosis30.4IL2RB, MIF
9hepatitis30.4IL2RB, MAGEA1, HGF
10glomerulonephritis30.4MIF
11psoriasis30.2S100A12, IL6
12diabetes mellitus30.2IL6
13sarcoma30.2MAGEA1
14osteoarthritis30.2ACP5, IL6
15hepatitis b30.2MIF, MAGEA1
16kawasaki disease30.2S100A12
17meningitis30.2IL6
18melanoma30.2HGF, PSMB9, DEK, MAGEA1, IL2RB, TAPBP
19pulmonary fibrosis30.2HGF
20graves' disease30.1PSMB9
21inflammatory bowel disease30.1IL6, S100A12
22influenza30.1IL2RB, PSMB9
23peritonitis30.1IL6
24iridocyclitis10.8
25uveitis10.8
26spondyloarthropathy10.6
27pauciarticular onset juvenile idiopathic arthritis10.5
28arthropathy10.5
29periodontitis10.5
30enthesitis-related juvenile idiopathic arthritis10.5
31reactive arthritis10.4
32vasculitis10.4
33iritis10.4
34cerebritis10.4
35psoriatic arthritis10.4
36juvenile glaucoma10.4
37acute leukemia10.4
38amyloidosis10.4
39cataract10.4
40dermatomyositis10.4
41glaucoma10.4
42lymphoblastic leukemia10.4
43polyarticular onset juvenile idiopathic arthritis10.4
44rubella10.3
45aggressive periodontitis10.3
46psoriatic juvenile idiopathic arthritis10.3
47bronchiolitis obliterans10.3
48bronchiolitis10.3
49childhood leukemia10.3
50hodgkin's lymphoma10.3

Graphical network of the top 20 diseases related to Juvenile Rheumatoid Arthritis:



Diseases related to juvenile rheumatoid arthritis

Clinical Features for Juvenile Rheumatoid Arthritis

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Sources:
46OMIM, 48Orphanet
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Clinical features from OMIM:

604302

Symptoms:

48 (show all 13)
  • splenomegaly
  • arthritis/synovitis/synovial proliferation
  • fever/chilling
  • articular/joint pain/arthralgia
  • hydrarthrosis/articular/joint effusion
  • cutaneous rash
  • autoimmunity/autoimmune reaction/autoantibodies
  • acute abdominal pain/colic
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • mediastinal/hilar adenopathies
  • hepatomegaly/liver enlargement (excluding storage disease)

Drugs & Therapeutics for Juvenile Rheumatoid Arthritis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Juvenile Rheumatoid Arthritis

Drug clinical trials:

Search ClinicalTrials for Juvenile Rheumatoid Arthritis

Search NIH Clinical Center for Juvenile Rheumatoid Arthritis

Search CenterWatch for Juvenile Rheumatoid Arthritis

Genetic Tests for Juvenile Rheumatoid Arthritis

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Anatomical Context for Juvenile Rheumatoid Arthritis

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Juvenile Rheumatoid Arthritis:

32
Testes, Skin, Bone, T cells, Liver, Myeloid, Monocytes, B cells, Whole blood, Eye, Endothelial, Kidney, Lung, Breast, Thyroid, Retina

FMA organs/tissues related to Juvenile Rheumatoid Arthritis:

14
Joint

Animal Models for Juvenile Rheumatoid Arthritis or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Juvenile Rheumatoid Arthritis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539710.4TAPBP, IL6, IL2RB, MIF, SH2D2A, C4B

Publications for Juvenile Rheumatoid Arthritis

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Sources:
50PubMed
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Articles related to Juvenile Rheumatoid Arthritis:

(show top 50)    (show all 601)
idTitleAuthorsYear
1
Juvenile idiopathic/rheumatoid arthritis and orthognatic surgery without mandibular osteotomies in the remittent phase. (24220378)
2013
2
T-cell lymphoma masquerading as juvenile rheumatoid arthritis. (22486797)
2012
3
Clinical, laboratory, and ultrasound assessment of the knee in juvenile rheumatoid arthritis. (21573036)
2011
4
Acute lymphoblastic leukemia masquerading as juvenile rheumatoid arthritis: diagnostic pitfall and association with survival. (19727722)
2010
5
Consultation with an arthritis specialist for children with suspected juvenile rheumatoid arthritis: a population-based study. (18524744)
2008
6
The kappa immunoglobulin light chain repertoire of peripheral blood B cells in patients with juvenile rheumatoid arthritis. (18614233)
2008
7
Improving adherence to medical regimens for juvenile rheumatoid arthritis. (17550635)
2007
8
Efficacy of thalidomide in systemic onset juvenile rheumatoid arthritis. (17706449)
2007
9
Keratoconjunctivitis sicca in juvenile rheumatoid arthritis. (17721292)
2007
10
Comparative usefulness of C-reactive protein and erythrocyte sedimentation rate in juvenile rheumatoid arthritis. (18078633)
2007
11
A case-control sleep study in children with polyarticular juvenile rheumatoid arthritis. (16511937)
2006
12
Association of two functional polymorphisms in the CCR5 gene with juvenile rheumatoid arthritis. (16775617)
2006
13
Long-term open-label preliminary study of the safety and efficacy of leflunomide in patients with polyarticular-course juvenile rheumatoid arthritis. (15693001)
2005
14
Association between the PTPN22 gene and rheumatoid arthritis and juvenile idiopathic arthritis in a UK population: further support that PTPN22 is an autoimmunity gene. (15934099)
2005
15
Juvenile rheumatoid arthritis affected sibpairs: extent of clinical phenotype concordance. (15188369)
2004
16
Acute hypoxic respiratory failure as the first manifestation of systemic-onset juvenile rheumatoid arthritis in a child. (15690560)
2004
17
Autologous hematopoietic stem cell transplantation for 3 patients with severe juvenile rheumatoid arthritis. (14704040)
2003
18
Quality-of-Life Measurements in Juvenile Rheumatoid Arthritis Patients Treated with Etanercept. (17535063)
2003
19
Radiologic outcome and its relationship to functional disability in juvenile rheumatoid arthritis. (12672208)
2003
20
High response rate in the phase I/II study of meloxicam in juvenile rheumatoid arthritis. (12022326)
2002
21
Current treatment of juvenile rheumatoid arthritis. (11773549)
2002
22
Immune complexes contain immunoglobulin A rheumatoid factor in serum and synovial fluid of patients with polyarticular juvenile rheumatoid arthritis. (11961181)
2002
23
Co-existent sickle cell disease and juvenile rheumatoid arthritis. Two cases with delayed diagnosis and severe destructive arthropathy. (11550986)
2001
24
Left ventricular diastolic functions in juvenile rheumatoid arthritis. (10865017)
2000
25
Clinical trials for the treatment of systemic onset juvenile rheumatoid arthritis-juvenile idiopathic arthritis. (11123076)
2000
26
Subspecialty referrals for pauciarticular juvenile rheumatoid arthritis. (10665597)
2000
27
Masticatory function in patients with juvenile rheumatoid arthritis. (10846730)
2000
28
Secondary glaucoma in patients with juvenile rheumatoid arthritis-associated iridocyclitis. (11037918)
2000
29
Clinical relevance of IgA rheumatoid factor (RF) in children with juvenile rheumatoid arthritis. (10651082)
1999
30
Stomatognathic function in juvenile rheumatoid arthritis and in developmental open-bite subjects. (10360201)
1999
31
Decreased physical function in juvenile rheumatoid arthritis. (11080999)
1999
32
Disease and family contributors to adaptation in juvenile rheumatoid arthritis and juvenile diabetes. (9782808)
1998
33
Substance use among adolescents with juvenile rheumatoid arthritis. (9830883)
1998
34
Identification of Th subsets in juvenile rheumatoid arthritis confirmed by intracellular cytokine staining. (9712118)
1998
35
Juvenile rheumatoid arthritis: ethnic differences in diagnostic types. (9292786)
1997
36
Molteno implantation for secondary glaucoma in juvenile rheumatoid arthritis. (9338669)
1997
37
Clinical analysis of 570 cases with juvenile rheumatoid arthritis: results of a nationwide retrospective survey in Japan. (9141266)
1997
38
Predictors of total body bone mineral density in non-corticosteroid-treated prepubertal children with juvenile rheumatoid arthritis. (9365085)
1997
39
Serum cytokines in juvenile rheumatoid arthritis. Correlation with conventional inflammation parameters and clinical subtypes. (7848311)
1995
40
Cytokine levels in serum and synovial fluid of patients with juvenile rheumatoid arthritis. (7699643)
1994
41
Cataract development and cataract surgery in patients with juvenile rheumatoid arthritis-associated iridocyclitis. (8510892)
1993
42
Studies of antibody to herpes simplex virus Fc gamma-binding protein gE in patients with rheumatoid arthritis, juvenile rheumatoid arthritis and normal controls. (1462119)
1992
43
The iridocyclitis of early onset pauciarticular juvenile rheumatoid arthritis: outcome in immunogenetically characterized patients. (1556680)
1992
44
The L1 protein as a new indicator of inflammatory activity in patients with juvenile rheumatoid arthritis. (2023183)
1991
45
Autoantibodies to nonhistone chromosomal proteins HMG-1 and HMG-2 in sera of patients with juvenile rheumatoid arthritis. (2403401)
1990
46
Rheumatoid arthritis, juvenile arthritis, iridocyclitis and the Epstein-Barr virus. (3006611)
1986
47
The risk of iridocyclitis in juvenile rheumatoid arthritis. (1082363)
1976
48
Iridocyclitis and pauciarticular juvenile rheumatoid arthritis. (5104123)
1971
49
Iridocyclitis in juvenile rheumatoid arthritis. (4978557)
1969
50
Dysplasia epiphysealis hemimelica. An unusual case combined with juvenile rheumatoid arthritis. (6078474)
1967

Genetic Variations for Juvenile Rheumatoid Arthritis

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Expression for genes affiliated with Juvenile Rheumatoid Arthritis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Juvenile Rheumatoid Arthritis

Search GEO for disease gene expression data for Juvenile Rheumatoid Arthritis.

Pathways for genes affiliated with Juvenile Rheumatoid Arthritis

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29KEGG, 53Reactome
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Compounds for genes affiliated with Juvenile Rheumatoid Arthritis

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Sources:
44Novoseek, 59Tocris Bioscience, 49PharmGKB, 11DrugBank, 24HMDB
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Compounds related to Juvenile Rheumatoid Arthritis according to GeneCards/GeneDecks:

(show all 20)
idCompoundScoreTop Affiliating Genes
1pmma4410.8ACP5, IL6, HGF
2pf 04217903 mesylate5910.8HGF, IL6
3su 112745910.8HGF, IL6
4pha 6657525910.7HGF, IL6
5endotoxin4410.7IL6, IL2RB, MIF, C4A, TNXA
6creatinine4410.7HGF, TNXA, MIF, IL2RB, IL6, ACP5
7rebamipide4410.7HGF, IL6
8crizotinib49 5911.7HGF, IL6
9ivig4410.7IL6, IL2RB, S100A12
10steroid4410.7TNXA, C4A, C4B, MIF, CYP21A1P, IL2RB
11alanine4410.6HGF, TNXA, MIF, IL2RB, IL6, TAPBP
12rantes4410.6ACP5, IL6, IL2RB
13polyacrylamide4410.6S100A12, TNXA, MIF, ACP5
14Intravenous Immunoglobulin1110.6C4A, C4B
15thalidomide44 49 59 1113.6IL6, MIF, HGF
16polysaccharide4410.5TAPBP, IL2RB, TNXA, HGF
17serine4410.5IL2RB, MIF
18olopatadine44 1111.5S100A12, IL6
19leukotriene b444 59 2412.3ACP5, IL6, IL2RB
20norepinephrine44 11 2412.2IL2RB

GO Terms for genes affiliated with Juvenile Rheumatoid Arthritis

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16Gene Ontology
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Cellular components related to Juvenile Rheumatoid Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.4HMGB2, IL6, MIF, C4B, C4A, HGF

Biological processes related to Juvenile Rheumatoid Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of apoptotic processGO:04306610.5HMGB2, HGF, PSMB9, MIF, IL2RB, IL6
2monocyte chemotaxisGO:00254810.4IL6, S100A12
3positive chemotaxisGO:05091810.4HMGB2, MIF, HGF
4inflammatory responseGO:00695410.3S100A12, C4A, C4B, MIF, IL6
5positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.2IL6, MIF, HGF

Molecular functions related to Juvenile Rheumatoid Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RAGE receptor bindingGO:05078610.4HMGB2, S100A12
2chemoattractant activityGO:04205610.1HMGB2, MIF, HGF

Products for genes affiliated with Juvenile Rheumatoid Arthritis

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Juvenile Rheumatoid Arthritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet