JIA
MCID: JVN010
MIFTS: 62

Juvenile Rheumatoid Arthritis (JIA) malady

Respiratory, Bone categories

Summaries for Juvenile Rheumatoid Arthritis

Sources:
8Disease Ontology, 21Genetics Home Reference, 34MedlinePlus, 64Wikipedia, 47OMIM, 33MalaCards
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MedlinePlus:34 Juvenile rheumatoid arthritis (jra) is a type of arthritis that happens in children age 16 or younger. it causes joint swelling, pain, stiffness, and loss of motion. it can affect any joint, and in some cases it can affect internal organs as well. one early sign of jra may be limping in the morning. symptoms can come and go. some children have just one or two flare-ups. others have symptoms that never go away. jra causes growth problems in some children. no one knows exactly what causes jra. scientists do know it is an autoimmune disorder, which means your immune system, which normally helps your body fight infection, attacks your body's own tissues. jra can be hard to diagnose. your health care provider may do a physical exam, lab tests, and x-rays. medicines and physical therapy can help maintain movement and reduce swelling and pain. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Juvenile Rheumatoid Arthritis, also known as rheumatoid arthritis, systemic juvenile, is related to arthritis and systemic lupus erythematosus, and has symptoms including hepatomegaly/liver enlargement (excluding storage disease), splenomegaly and arthritis/synovitis/synovial proliferation. An important gene associated with Juvenile Rheumatoid Arthritis is IL6 (interleukin 6 (interferon, beta 2)), and among its related pathways are Rheumatoid arthritis and Interleukin-3, 5 and GM-CSF signaling. The compounds pmma and pf 04217903 mesylate have been mentioned in the context of this disorder. Affiliated tissues include joint, skin and liver, and related mouse phenotype hematopoietic system.

Disease Ontology:8 A rheumatoid arthritis that involves an autoimmune disease onset in children under 16 which attacks the healthy cells and tissue of located in joint.

Genetics Home Reference:21 Juvenile idiopathic arthritis refers to a group of conditions involving joint inflammation (arthritis) that first appears before the age of 16. This condition is an autoimmune disorder, which means that the immune system malfunctions and attacks the body's organs and tissues, in this case the joints.

Wikipedia:64 Juvenile idiopathic arthritis (JIA), also known as juvenile rheumatoid arthritis (JRA), is the most... more...

Description from OMIM:47 604302

Aliases & Classifications for Juvenile Rheumatoid Arthritis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 21Genetics Home Reference, 47OMIM, 10DISEASES, 45Novoseek, 49Orphanet, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 27ICD9CM, 26ICD10 via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory, Bone


Characteristics (Orphanet epidemiological data):

49
systemic-onset juvenile idiopathic arthritis:
Prevalence: 1-9/100000; Age of onset: Childhood; Age of death: Normal


Aliases & Descriptions:

juvenile rheumatoid arthritis 8 43 21 10 34
rheumatoid arthritis, systemic juvenile 47 45 61
arthritis, juvenile rheumatoid 43 21 61
juvenile idiopathic arthritis 8 43 21
monarticular juvenile rheumatoid arthritis 8 61
juvenile chronic polyarthritis 8 61
juvenile chronic arthritis 43 21
acute polyarticular juvenile rheumatoid arthritis 61
pauciarticular onset juvenile chronic arthritis 8
systemic-onset juvenile idiopathic arthritis 49
systemic juvenile rheumatoid arthritis 21
acute juvenile rheumatoid arthritis 8
pauciarticular juvenile arthritis 8
arthritis juvenile rheumatoid 45
juvenile-onset still disease 61
systemic polyarthritis 49
juvenile arthritis 43
still disease 49
juvenile ra 21
jra 21
jia 21


External Ids:

Disease Ontology8 DOID:676
ICD9CM27 714.31
OMIM47 604302
ICD10 via Orphanet26 M08.2

Related Diseases for Juvenile Rheumatoid Arthritis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the rheumatoid arthritis family:

juvenile rheumatoid arthritis

Diseases related to Juvenile Rheumatoid Arthritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 222)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis32.3ACP5, IL6, IL2RB, MIF, S100A12, PSMB9
2systemic lupus erythematosus31.0C4B, C4A, DEK, MIF, CYP21A1P, IL2RB
3synovitis30.8IL6
4asthma30.7MIF, S100A12
5osteoarthritis30.2ACP5, IL6
6kawasaki disease30.2S100A12
7graves' disease30.2PSMB9
8enthesitis-related juvenile idiopathic arthritis10.8
9uveitis10.8
10enthesitis-related arthritis10.7
11anterior uveitis10.6
12psoriatic juvenile idiopathic arthritis10.6
13idiopathic anterior uveitis10.6
14pauciarticular onset juvenile idiopathic arthritis10.5
15n syndrome10.5
16spondyloarthropathy10.5
17arthropathy10.5
18vasculitis10.5
19rheumatoid vasculitis10.5
20oligoarticular juvenile arthritis10.5
21iritis10.4
22psoriatic arthritis10.4
23juvenile glaucoma10.4
24acute leukemia10.4
25amyloidosis10.4
26juvenile psoriatic arthritis10.4
27rubella10.4
28aggressive periodontitis10.4
29bronchiolitis obliterans10.3
30bronchiolitis10.3
31q fever10.3
32felty's syndrome10.3
33rh deficiency syndrome10.3
34reactive arthritis10.3
35transient arthritis10.3
36turner syndrome10.3
37sickle cell disease10.3
38progressive pseudorheumatoid arthropathy of childhood10.3
39polyarticular onset juvenile idiopathic arthritis10.3
40systemic onset juvenile idiopathic arthritis10.3
41amyloidosis, secondary10.3
42atlantoaxial subluxation10.3
43crohn's disease10.3
44cardiac tamponade10.3
45familial mediterranean fever10.3
46hepatitis e10.3
47common variable immunodeficiency10.3
48measles10.3
49mumps10.3
50urticaria10.3

Graphical network of the top 20 diseases related to Juvenile Rheumatoid Arthritis:



Diseases related to juvenile rheumatoid arthritis

Clinical Features for Juvenile Rheumatoid Arthritis

Sources:
47OMIM, 49Orphanet
See all sources

Clinical features from OMIM:

604302

Symptoms:

49 (show all 13)
  • hepatomegaly/liver enlargement (excluding storage disease)
  • splenomegaly
  • arthritis/synovitis/synovial proliferation
  • fever/chilling
  • articular/joint pain/arthralgia
  • hydrarthrosis/articular/joint effusion
  • cutaneous rash
  • autoimmunity/autoimmune reaction/autoantibodies
  • acute abdominal pain/colic
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • mediastinal/hilar adenopathies

Drugs & Therapeutics for Juvenile Rheumatoid Arthritis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Juvenile Rheumatoid Arthritis

Drug clinical trials:

Search ClinicalTrials for Juvenile Rheumatoid Arthritis

Search NIH Clinical Center for Juvenile Rheumatoid Arthritis

Search CenterWatch for Juvenile Rheumatoid Arthritis

Genetic Tests for Juvenile Rheumatoid Arthritis

Anatomical Context for Juvenile Rheumatoid Arthritis

Sources:
14FMA, 33MalaCards
See all sources

MalaCards organs/tissues related to Juvenile Rheumatoid Arthritis:

33
Skin, Liver, Kidney, Lung, Whole blood, Retina, Skeletal muscle, Thyroid, Breast, Myeloid, Monocytes, T cells, B lymphoblasts, B cells, Endothelial

FMA organs/tissues related to Juvenile Rheumatoid Arthritis:

14
Joint

Animal Models for Juvenile Rheumatoid Arthritis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Juvenile Rheumatoid Arthritis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539710.4TAPBP, IL6, IL2RB, MIF, SH2D2A, C4B

Publications for Juvenile Rheumatoid Arthritis

Sources:
51PubMed
See all sources

Articles related to Juvenile Rheumatoid Arthritis:

(show top 50)    (show all 602)
idTitleAuthorsYear
1
The Importance of General Self-Efficacy for the Quality of Life of Adolescents with Diabetes or Juvenile Rheumatoid Arthritis Over Time: A Longitudinal Study among Adolescents and Parents. (24400286)
2013
2
Relation of dry eye to disease activity in juvenile rheumatoid arthritis. (21928273)
2012
3
Recurrent fever of unknown origin (FUO): aseptic meningitis, hepatosplenomegaly, pericarditis and a double quotidian fever due to juvenile rheumatoid arthritis (JRA). (21453973)
2012
4
Dominant vertebral artery injury during posterior atlantoaxial transarticular screw fixation in a juvenile rheumatoid arthritis patient with atlantoaxial subluxation. (22358143)
2012
5
Is this acute lymphoblastic leukaemia or juvenile rheumatoid arthritis. (22315865)
2011
6
Ross operation in a patient with juvenile rheumatoid arthritis. (20667306)
2010
7
Adalimumab in juvenile rheumatoid arthritis. (19065749)
2008
8
Neutrophilic panniculitis in infancy: a cutaneous manifestation of juvenile rheumatoid arthritis. (17938028)
2007
9
Clinical and ultrasound assessment of the knee in children with juvenile rheumatoid arthritis. (17901669)
2007
10
Review of medications used in juvenile rheumatoid arthritis. (17228221)
2007
11
Allelic frequency of the MCP-1 promoter -2518 polymorphism in the Turkish population and in Turkish patients with juvenile rheumatoid arthritis. (16835702)
2007
12
Hip disease in juvenile rheumatoid arthritis. (16539201)
2006
13
Clinically diagnosed fatal cerebral vasculitis in long-standing juvenile rheumatoid arthritis. (16328354)
2006
14
Natural killer cell dysfunction is a distinguishing feature of systemic onset juvenile rheumatoid arthritis and macrophage activation syndrome. (15642140)
2005
15
Taiwan experience with etanercept in juvenile rheumatoid arthritis. (16341348)
2005
16
A case of adult-onset Felty syndrome in juvenile rheumatoid arthritis. (16118895)
2005
17
Intra-articular calcifications in a child with juvenile rheumatoid arthritis. (16177158)
2005
18
Novel approaches to gene expression analysis of active polyarticular juvenile rheumatoid arthritis. (14979934)
2004
19
Monitoring neutrophil activation in juvenile rheumatoid arthritis by S100A12 serum concentrations. (15077313)
2004
20
Polymorphism of human HLA-DRB1 leukocyte antigen alleles and its association to juvenile rheumatoid arthritis in a sample of Colombian mestizo children]. (14582328)
2003
21
Etanercept: an updated review of its use in rheumatoid arthritis, psoriatic arthritis and juvenile rheumatoid arthritis. (12421111)
2002
22
Prevalence of human leukocyte antigen (HLA) DRB1 alleles in Kuwaiti children with juvenile rheumatoid arthritis. (11841481)
2002
23
The prevalence of uveitis in juvenile rheumatoid arthritis. (11182663)
2001
24
Keratonconjunctivitis sicca is not uncommon in children with juvenile rheumatoid arthritis. (11411961)
2001
25
Safety and efficacy of high dose etanercept in treatment of juvenile rheumatoid arthritis. (11469478)
2001
26
Sulfasalazine for the management of juvenile rheumatoid arthritis. (11327261)
2001
27
Risk and resistance factors in the adaptation in mothers of children with juvenile rheumatoid arthritis. (11329483)
2001
28
What's new in the diagnosis and treatment of juvenile rheumatoid arthritis. (10912594)
2000
29
Efficacy of recombinant human growth hormone in children with juvenile rheumatoid arthritis and growth failure. (10968478)
2000
30
High dose, alternate day corticosteroids for systemic onset juvenile rheumatoid arthritis. (10955346)
2000
31
Juvenile rheumatoid arthritis. (10503657)
1999
32
Juvenile rheumatoid arthritis as a complex genetic trait. (10555018)
1999
33
The effect of methotrexate on the temporomandibular joint in polyarticular juvenile rheumatoid arthritis patients. (19078423)
1999
34
Interleukin 1beta mediated calciotropic activity in serum of children with juvenile rheumatoid arthritis. (9458222)
1998
35
Fibrin D-dimer as a marker of disease activity in systemic onset juvenile rheumatoid arthritis. (9712110)
1998
36
Radiologic case study. Overgrowth of an epiphysis in juvenile rheumatoid arthritis. (9474640)
1998
37
Raised IgM antibodies to parvovirus B19 in juvenile rheumatoid arthritis. (9529776)
1998
38
Measuring disability in early juvenile rheumatoid arthritis: evaluation of a Norwegian version of the childhood Health Assessment Questionnaire. (9733471)
1998
39
Antibodies against a peptide sequence located in the linker region of the HMG-1/2 box domains in sera from patients with juvenile rheumatoid arthritis. (9336414)
1997
40
In vitro induction of proinflammatory cytokine secretion by juvenile rheumatoid arthritis synovial fluid immune complexes. (9365094)
1997
41
The long-term effect of methotrexate therapy on the liver in patients with juvenile rheumatoid arthritis. (9416861)
1997
42
Juvenile rheumatoid arthritis: The Saudi Experience. (17353592)
1997
43
Ultrasonography in the early diagnosis of hip joint involvement in juvenile rheumatoid arthritis. (9292810)
1997
44
Functional alpha 1-adrenergic receptors on leukocytes of patients with polyarticular juvenile rheumatoid arthritis. (8982123)
1996
45
Patterns of expression of tumor necrosis factor alpha, tumor necrosis factor beta, and their receptors in synovia of patients with juvenile rheumatoid arthritis and juvenile spondylarthropathy. (8843861)
1996
46
Immune responses to the Escherichia coli dnaJ heat shock protein in juvenile rheumatoid arthritis and their correlation with disease activity. (8151470)
1994
47
Elevated soluble CD8 antigen and soluble interleukin-2 receptors in the sera of patients with juvenile rheumatoid arthritis. (8513595)
1993
48
Severe anemia associated with active systemic-onset juvenile rheumatoid arthritis successfully treated with recombinant human erythropoietin: a pilot study. (1599527)
1992
49
Aortic valve insufficiency and coronary artery narrowing in a child with polyarticular juvenile rheumatoid arthritis. (3280793)
1988
50
Lymphoid interstitial pneumonia in juvenile rheumatoid arthritis. (6502346)
1984

Genetic Variations for Juvenile Rheumatoid Arthritis

Expression for genes affiliated with Juvenile Rheumatoid Arthritis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Juvenile Rheumatoid Arthritis

Search GEO for disease gene expression data for Juvenile Rheumatoid Arthritis.

Pathways for genes affiliated with Juvenile Rheumatoid Arthritis

Sources:
30KEGG, 54Reactome
See all sources

Compounds for genes affiliated with Juvenile Rheumatoid Arthritis

Sources:
45Novoseek, 60Tocris Bioscience, 50PharmGKB, 11DrugBank, 24HMDB
See all sources

Compounds related to Juvenile Rheumatoid Arthritis according to GeneCards/GeneDecks:

(show all 20)
idCompoundScoreTop Affiliating Genes
1pmma4510.8ACP5, IL6, HGF
2pf 04217903 mesylate6010.8HGF, IL6
3su 112746010.8HGF, IL6
4pha 6657526010.7HGF, IL6
5endotoxin4510.7IL6, IL2RB, MIF, C4A, TNXA
6creatinine4510.7HGF, TNXA, MIF, IL2RB, IL6, ACP5
7rebamipide4510.7HGF, IL6
8crizotinib50 6011.7HGF, IL6
9ivig4510.7IL6, IL2RB, S100A12
10steroid4510.7TNXA, C4A, C4B, MIF, CYP21A1P, IL2RB
11alanine4510.6HGF, TNXA, MIF, IL2RB, IL6, TAPBP
12rantes4510.6ACP5, IL6, IL2RB
13polyacrylamide4510.6S100A12, TNXA, MIF, ACP5
14Intravenous Immunoglobulin1110.6C4A, C4B
15thalidomide45 50 60 1113.6IL6, MIF, HGF
16polysaccharide4510.5TAPBP, IL2RB, TNXA, HGF
17serine4510.5IL2RB, MIF
18olopatadine45 1111.5S100A12, IL6
19leukotriene b445 60 2412.3ACP5, IL6, IL2RB
20norepinephrine45 11 2412.2IL2RB

GO Terms for genes affiliated with Juvenile Rheumatoid Arthritis

Sources:
16Gene Ontology
See all sources

Cellular components related to Juvenile Rheumatoid Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.4HMGB2, IL6, MIF, C4B, C4A, HGF

Biological processes related to Juvenile Rheumatoid Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of apoptotic processGO:04306610.5IL2RB, HGF, PSMB9, MIF, HMGB2, IL6
2monocyte chemotaxisGO:00254810.4S100A12, IL6
3positive chemotaxisGO:05091810.4MIF, HMGB2, HGF
4inflammatory responseGO:00695410.3S100A12, C4A, C4B, MIF, IL6
5positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.2HGF, MIF, IL6

Molecular functions related to Juvenile Rheumatoid Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RAGE receptor bindingGO:05078610.4HMGB2, S100A12
2chemoattractant activityGO:04205610.1HMGB2, MIF, HGF

Products for genes affiliated with Juvenile Rheumatoid Arthritis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Juvenile Rheumatoid Arthritis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet