MCID: JVN003
MIFTS: 40

Juvenile Xanthogranuloma malady

Skin diseases, Rare diseases, Immune diseases categories

Aliases & Classifications for Juvenile Xanthogranuloma

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Sources:
10Disease Ontology, 47Novoseek, 12DISEASES, 51Orphanet, 65UMLS, 36MeSH, 59SNOMED-CT, 42NCIt, 66UMLS via Orphanet, 28ICD10 via Orphanet, 37MESH via Orphanet
See all sources

Aliases & Descriptions for Juvenile Xanthogranuloma:

Name: Juvenile Xanthogranuloma 10 47 12 51 65
Multiple Eruptive Juvenile Xanthogranuloma 10
Xanthogranuloma, Juvenile 36
 
Naevoxanthoendothelioma 10
Xanthoma Neviforme 10


Classifications:

Orphanet: 51 
Rare skin diseases


External Ids:

Disease Ontology10 DOID:4424
MeSH36 D014972
NCIt42 C3451
Orphanet51 158000
UMLS via Orphanet66 C0043324
ICD10 via Orphanet28 D76.3
MESH via Orphanet37 D014972

Summaries for Juvenile Xanthogranuloma

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Wikipedia:68 Juvenile xanthogranuloma is a form of histiocytosis, classified as \"non-Langerhans cell... more...

MalaCards based summary: Juvenile Xanthogranuloma, also known as multiple eruptive juvenile xanthogranuloma, is related to neuritis and histiocytosis, and has symptoms including abnormality of the oral cavity, visual impairment and abnormality of the anterior chamber. An important gene associated with Juvenile Xanthogranuloma is F13A1 (Coagulation Factor XIII, A1 Polypeptide), and among its related pathways is Aurora B signaling. Affiliated tissues include bone, skin and eye.

Related Diseases for Juvenile Xanthogranuloma

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Diseases in the Adult Xanthogranuloma family:

juvenile xanthogranuloma

Diseases related to Juvenile Xanthogranuloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 158)
idRelated DiseaseScoreTop Affiliating Genes
1neuritis30.0DES, S100B, VIM
2histiocytosis10.7
3langerhans-cell histiocytosis10.7
4neurofibromatosis10.7
5leukemia10.6
6cervicitis10.5
7neurofibromatosis, type 110.4
8urticaria pigmentosa10.4
9urticaria10.4
10rosai-dorfman disease10.4
11pick disease10.3
12niemann-pick disease10.3
13chorioretinitis10.3
14cutaneous mastocytosis10.3
15lymphoblastic leukemia10.3
16myeloid leukemia10.3
17uveitis10.3
18mastocytosis10.3
19benign cephalic histiocytosis10.3
20dyskinesia of esophagus10.2F13A1, VIM
21heart valve disease10.2F13A1, VIM
22juvenile macular degeneration and hypotrichosis10.2F13A1, VIM
23orbit alveolar rhabdomyosarcoma10.2DES, F13A1
24infantile free sialic acid storage disease10.2DES, VIM
25lymphatic neoplasm10.2DES, VIM
26kidney leiomyosarcoma10.2DES, VIM
27esophageal lipoma10.2DES, VIM
28esophageal disease10.2DES, VIM
29absence of fingerprints congenital milia10.2DES, VIM
30malignant teratocarcinosarcoma10.2DES, VIM
31bladder colonic type adenocarcinoma10.2DES, VIM
32epithelioid cell synovial sarcoma10.2DES, VIM
33benign multicystic peritoneal mesothelioma10.2DES, VIM
34hemiplegia10.2F13A1, VIM
35psoriasis10.2DES, VIM
36internal hemorrhoid10.2DES, VIM
37pancreatic colloid cystadenoma10.2DES, VIM
38infantile recurrent chronic multifocal osteomyolitis10.2DES, VIM
39rift valley fever10.2DES, VIM
40familial syringomyelia10.2DES, VIM
41mesenchymoma10.2DES, VIM
42glossitis10.2DES, VIM
43localized pulmonary fibrosis10.2DES, VIM
44female reproductive organ cancer10.1DES, VIM
45glomerulosclerosis10.1DES, VIM
46wiskott-aldrich syndrome10.1
47acute leukemia10.1
48cataract10.1
49follicular lymphoma10.1
50hemangioma10.1

Graphical network of the top 20 diseases related to Juvenile Xanthogranuloma:



Diseases related to juvenile xanthogranuloma

Symptoms for Juvenile Xanthogranuloma

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Symptoms:

 51 (show all 9)
  • follicular/erythematous/edematous papules/milium
  • anterior chamber anomaly
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
  • visual loss/blindness/amblyopia
  • enanthema/aphtosa/aphta/leukoplakia
  • cafe-au-lait spot
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • structural anomalies of the respiratory system and diaphragm
  • myeloproliferative syndrome/chronic leukemia

HPO human phenotypes related to Juvenile Xanthogranuloma:

(show all 7)
id Description Frequency HPO Source Accession
1 abnormality of the oral cavity occasional (7.5%) HP:0000163
2 visual impairment occasional (7.5%) HP:0000505
3 abnormality of the anterior chamber occasional (7.5%) HP:0000593
4 cafe-au-lait spot occasional (7.5%) HP:0000957
5 leukemia occasional (7.5%) HP:0001909
6 abnormality of the respiratory system occasional (7.5%) HP:0002086
7 inflammatory abnormality of the eye occasional (7.5%) HP:0100533

Drugs & Therapeutics for Juvenile Xanthogranuloma

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Interventional clinical trials:

idNameStatusNCT IDPhase
1International Rare Histiocytic Disorders Registry (IRHDR)RecruitingNCT02285582

Search NIH Clinical Center for Juvenile Xanthogranuloma


Cochrane evidence based reviews: Xanthogranuloma, Juvenile

Genetic Tests for Juvenile Xanthogranuloma

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Anatomical Context for Juvenile Xanthogranuloma

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MalaCards organs/tissues related to Juvenile Xanthogranuloma:

33
Bone, Skin, Eye, Brain, Tongue, Bone marrow, Liver

Animal Models for Juvenile Xanthogranuloma or affiliated genes

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MGI Mouse Phenotypes related to Juvenile Xanthogranuloma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes

Publications for Juvenile Xanthogranuloma

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Articles related to Juvenile Xanthogranuloma:

(show top 50)    (show all 380)
idTitleAuthorsYear
1
In vivo evaluation of juvenile xanthogranuloma with high-resolution optical coherence tomography and reflectance confocal microscopy and histopathological correlation. (25801534)
2015
2
Juvenile xanthogranuloma of supra-sellar region: a rare presentation. (26308252)
2015
3
Juvenile xanthogranuloma with bilateral retinal detachment. (25787311)
2015
4
Intracardiac juvenile xanthogranuloma with presentation in adulthood. (24012116)
2014
5
Erosive and mitotically active juvenile xanthogranuloma on the neck of an infant. (25187300)
2014
6
Three different ophthalmic presentations of juvenile xanthogranuloma. (24914080)
2014
7
Case series of volar juvenile xanthogranuloma: clinical observation of a peripheral rim of hyperkeratosis. (25227151)
2014
8
Isolated intracranial juvenile xanthogranuloma. A report of two cases and review of the literature. (25281434)
2014
9
Juvenile xanthogranuloma: an unusual cause of intratesticular mass in childhood. (24582118)
2014
10
Wiskott-Aldrich syndrome caused by a new mutation associated with multifocal dermal juvenile xanthogranulomas. (23157619)
2013
11
Infantile juvenile xanthogranuloma of the chest wall mimicking mesenchymal hamartoma: report of a case. (22864545)
2012
12
Juvenile xanthogranuloma developing after treatment of Langerhans cell histiocytosis: case report and literature review. (22977671)
2012
13
Juvenile xanthogranuloma presenting as bilateral non-infiltrative extraconal superior orbital tumour in a 27 year old nigerian woman: features, management and outcome. (23071425)
2012
14
Solitary juvenile xanthogranuloma in the lung of a young adult. (21753717)
2011
15
Langerhans cell histiocytosis preceding the development of juvenile xanthogranuloma: a case and review of recent developments. (21793710)
2011
16
Rare presentation of juvenile xanthogranuloma in the thoracic spine of an adult patient: case report and literature review. (21626171)
2011
17
Neonatal systemic juvenile xanthogranuloma with an ominous presentation and successful treatment. (21695102)
2011
18
Rapid-growing juvenile xanthogranuloma: The reality of a second opinion teleconsultation. Letters to the editor. (20695867)
2010
19
Solitary juvenile xanthogranuloma in the upper cervical spine: case report and review of the literatures. (18228052)
2008
20
An 'eruptive' variant of juvenile xanthogranuloma associated with langerhans cell histiocytosis. (18840155)
2008
21
What's your diagnosis? Juvenile xanthogranuloma of the iris. (18404952)
2008
22
Juvenile xanthogranuloma of the finger: an unusual localization. (17683396)
2007
23
Juvenile xanthogranuloma en plaque. (18036001)
2007
24
Congenital plaque on the chest. Diagnosis: solitary giant congenital juvenile xanthogranuloma. (17376208)
2007
25
Juvenile xanthogranuloma associated with contralateral lymphadenopathy. (16190992)
2005
26
Linear juvenile xanthogranuloma. (15283809)
2004
27
Histopathologic maturation of juvenile xanthogranuloma in a short period. (11358553)
2001
28
Isolated juvenile xanthogranuloma of the subglottis: case report. (11295817)
2001
29
Benign cephalic histiocytosis progressing into juvenile xanthogranuloma: a non-Langerhans cell histiocytosis transforming under the influence of a virus? (10698221)
2000
30
Juvenile xanthogranuloma variant: a clinicopathological case report and review of the literature. (10658117)
1999
31
Severe systemic toxicity caused by brimonidine drops in an infant with presumed juvenile xanthogranuloma. (10707152)
1999
32
Rosai-Dorfman disease and juvenile xanthogranuloma. (9185229)
1997
33
Diagnosis and management of iris juvenile xanthogranuloma. (9027680)
1997
34
Juvenile xanthogranuloma occurring in the oral cavity: case report and histopathological findings. (9416582)
1997
35
Juvenile xanthogranuloma: report of case. (8530991)
1996
36
Benign juvenile xanthogranuloma of the larynx. (7607823)
1995
37
Juvenile xanthogranuloma. (7616589)
1995
38
Ocular lesions in patients with cutaneous juvenile xanthogranuloma. (8123585)
1994
39
Juvenile xanthogranuloma with extra-cutaneous lesions--a case report. (7748839)
1994
40
Aquagenic pruritus associated with juvenile xanthogranuloma. (8348719)
1993
41
Early treatment of juvenile xanthogranuloma of the iris with subconjunctival steroids. (8435403)
1993
42
Unusual aspects of juvenile xanthogranuloma. (8408830)
1993
43
Congenital macronodular juvenile xanthogranuloma of the eyelid. (1923358)
1991
44
Juvenile xanthogranuloma and neurofibromatosis. (1792210)
1991
45
Juvenile xanthogranuloma with pulmonary lesions. (3124069)
1988
46
Pathologic quiz case 1. Adolescent (juvenile) xanthogranuloma. (3118907)
1987
47
Juvenile xanthogranulomas and xanthoma disseminatum--variations on a single theme. (3088071)
1986
48
Juvenile xanthogranuloma of the oral mucosa. (6795560)
1981
49
Juvenile xanthogranuloma and urticaria pigmentosa. (804295)
1975
50
Juvenile xanthogranuloma. (4629468)
1972

Variations for Juvenile Xanthogranuloma

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Expression for genes affiliated with Juvenile Xanthogranuloma

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Search GEO for disease gene expression data for Juvenile Xanthogranuloma.

Pathways for genes affiliated with Juvenile Xanthogranuloma

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Pathways related to Juvenile Xanthogranuloma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6DES, VIM

GO Terms for genes affiliated with Juvenile Xanthogranuloma

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Biological processes related to Juvenile Xanthogranuloma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:00300499.6DES, VIM

Molecular functions related to Juvenile Xanthogranuloma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:00428028.3DES, LYZ, S100B, VIM

Sources for Juvenile Xanthogranuloma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet