MCID: KLL008
MIFTS: 15

Kallmann Syndrome 6 malady

Categories: Genetic diseases, Rare diseases, Reproductive diseases, Endocrine diseases, Smell/Taste diseases

Aliases & Classifications for Kallmann Syndrome 6

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Aliases & Descriptions for Kallmann Syndrome 6:

Name: Kallmann Syndrome 6 47 26 67
 
Kal6 47

Classifications:



Summaries for Kallmann Syndrome 6

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MalaCards based summary: Kallmann Syndrome 6, also known as kal6, is related to hypogonadotropic hypogonadism 6 with or without anosmia and fgf8-related isolated gonadotropin-releasing hormone deficiency. An important gene associated with Kallmann Syndrome 6 is FGF8 (Fibroblast Growth Factor 8).

Related Diseases for Kallmann Syndrome 6

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Diseases in the Kallmann Syndrome family:

Kallmann Syndrome 3 Kallmann Syndrome 4
Kallmann Syndrome 5 kallmann syndrome 6

Diseases related to Kallmann Syndrome 6 via text searches within MalaCards or GeneCards Suite gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1hypogonadotropic hypogonadism 6 with or without anosmia11.0
2fgf8-related isolated gonadotropin-releasing hormone deficiency11.0

Symptoms for Kallmann Syndrome 6

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Drugs & Therapeutics for Kallmann Syndrome 6

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Drugs for Kallmann Syndrome 6 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Letrozoleapproved, investigationalPhase 2, Phase 3382112809-51-53902
Synonyms:
1-[Bis-(4-cyanophenyl)methyl]-1,2,4-triazole
1-[bis(4-cyanophenyl)methyl]-1,2,4-triazole
112809-51-5
4,4'-((1h-1,2,4-triazol-1-yl)methylene)dibenzonitrile
4,4'-(1H-1,2,4-Triazol-1-ylmethylene)dibenzonitrile
4,4'-(1H-1,2,4-triazol-1-yl-methylene)-bis(benzonitrile)
4,4'-(1H-1,2,4-triazol-1-ylmethanediyl)dibenzonitrile
4,4'-(1H-1,2,4-triazol-1-ylmethylene)bis-Benzonitrile Letrozole
4,4'-(1h-1,2,4-triazol-1-ylmethylene) bis-benzonitrile
4,4'-(1h-1,2,4-triazol-1-ylmethylene)bis-benzonitrile
4,4'-(1h-1,2,4-triazol-1-ylmethylene)bisbenzonitrile
4-[(4-cyanophenyl)-(1,2,4-triazol-1-yl)methyl]benzonitrile
AB00514009
AC-1193
AC1L1GYT
AKOS005145822
BIDD:GT0015
BIDD:PXR0130
BPBio1_001331
BRD-K88789588-001-03-2
BSPBio_001209
Bio-0057
C067431
C08163
C17H11N5
CAS-112809-51-5
CCRIS 8822
CGS 20267
CGS 20267, Femara, Piroxicam, Letrozole
CGS-20267
CHEBI:6413
CHEMBL1444
CID3902
CPD000466343
D00964
 
DB01006
FEM-345
Femara
Femara (TN)
Femera
HMS1571M11
HMS2051E08
HMS2089L22
HSDB 7461
I06-0022
LS-38788
Letoval
Letrozol
Letrozole
Letrozole (JAN/USP/INN)
Letrozole [USAN:INN]
MLS000759455
MLS001424038
MLS002584991
MolPort-003-848-373
NCGC00016973-01
NCGC00016973-02
NSC719345
Novartis Brand of Letrozole
Prestwick0_001025
Prestwick1_001025
Prestwick2_001025
Prestwick3_001025
S1235_Selleck
SAM001246649
SMR000466343
SPBio_003070
TL8000371
UNII-7LKK855W8I
ZINC03778874
letrozole
2LHRH, N-Ac-2-Nal(1)-4-Cl-Phe(2)-3-Pal(3)-Arg(5)-Glu(6)-AlaNH2(10)-Phase 2, Phase 32
3Prolactin Release-Inhibiting FactorsPhase 2, Phase 374
4Steroid Synthesis InhibitorsPhase 2, Phase 31718
5Aromatase InhibitorsPhase 2, Phase 3807
6Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 2, Phase 312767
7EstrogensPhase 2, Phase 32470
8HormonesPhase 2, Phase 313979
9Hormone AntagonistsPhase 2, Phase 312778
10Estrogen AntagonistsPhase 2, Phase 31315
11phenylalanineNutraceuticalPhase 2, Phase 3158

Interventional clinical trials:

idNameStatusNCT IDPhase
1Letrozole Treatment in Normal and GnRH Deficient WomenActive, not recruitingNCT00351416Phase 2, Phase 3
2Kisspeptin in the Evaluation of Delayed PubertyRecruitingNCT01438034Phase 1
3Health Needs of Patients With Kallmann SyndromeActive, not recruitingNCT01914172

Search NIH Clinical Center for Kallmann Syndrome 6

Genetic Tests for Kallmann Syndrome 6

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Genetic tests related to Kallmann Syndrome 6:

id Genetic test Affiliating Genes
1 Kallmann Syndrome 626

Anatomical Context for Kallmann Syndrome 6

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Animal Models for Kallmann Syndrome 6 or affiliated genes

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Publications for Kallmann Syndrome 6

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Variations for Kallmann Syndrome 6

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Clinvar genetic disease variations for Kallmann Syndrome 6:

5
id Gene Variation Type Significance SNP ID Assembly Location
1FGF8NM_033163.3(FGF8): c.77C> T (p.Pro26Leu)SNVPathogenicrs137852660GRCh37Chr 10, 103534966: 103534966

Expression for genes affiliated with Kallmann Syndrome 6

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Search GEO for disease gene expression data for Kallmann Syndrome 6.

Pathways for genes affiliated with Kallmann Syndrome 6

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GO Terms for genes affiliated with Kallmann Syndrome 6

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Sources for Kallmann Syndrome 6

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet