MCID: KPS004
MIFTS: 68

Kaposi Sarcoma malady

Genetic diseases, Cancer diseases, Infectious diseases, Rare diseases categories

Summaries for Kaposi Sarcoma

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OMIM:45 Kaposi sarcoma (KS) is an invasive angioproliferative inflammatory condition that occurs commonly in men infected with... (148000) more...

MalaCards based summary: Kaposi Sarcoma, also known as kaposi's sarcoma, is related to sarcoma and classic kaposi sarcoma, and has symptoms including autosomal dominant inheritance, edema and hypermelanotic macule. An important gene associated with Kaposi Sarcoma is IL6 (interleukin 6 (interferon, beta 2)), and among its related pathways are Malaria and HIF-1 signaling pathway. The drugs etoposide and interferon alfa-2a and the compounds tocilizumab and pegasys have been mentioned in the context of this disorder. Affiliated tissues include lung, skin and prostate, and related mouse phenotypes are liver/biliary system and respiratory system.

Disease Ontology:9 A connective tissue cancer that derives from lymphatic endothelium, and derives from spindle cells, results in formation of vascular channels that fill with blood cells, has material basis in human herpesvirus 8 (hhv8).

MedlinePlus:32 Kaposi's sarcoma is a cancer that causes patches of abnormal tissue to grow under the skin, in the lining of the mouth, nose, and throat or in other organs. the patches are usually red or purple and are made of cancer cells and blood cells. the red and purple patches often cause no symptoms, though they may be painful. if the cancer spreads to the digestive tract or lungs, bleeding can result. lung tumors can make breathing hard. before the hiv/aids epidemic, ks usually developed slowly. in hiv/aids patients, though, the disease moves quickly. treatment depends on where the lesions are and how bad they are. treatment for hiv itself can shrink the lesions. however, treating ks does not improve survival from hiv/aids itself. nih: national cancer institute

Aliases & Classifications for Kaposi Sarcoma

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Sources:
45OMIM, 9Disease Ontology, 10diseasecard, 43Novoseek, 47Orphanet, 32MedlinePlus, 60UMLS, 55SNOMED-CT, 27ICD9CM, 33MeSH, 38NCIt, 26ICD10 via Orphanet, 61UMLS via Orphanet, 34MESH via Orphanet, 25ICD10
See all sources

Kaposi Sarcoma, Aliases & Descriptions:

Name: Kaposi Sarcoma 45 9 43 60
Kaposi's Sarcoma 9 47 32
Kaposi's Sarcoma of Gastrointestinal Sites 9 60
Kaposi's Sarcoma of Lymph Nodes 9 60
Kaposi's Sarcoma of Soft Tissue 9 60
Kaposi's Sarcoma of Conjunctiva 9 60
Gallbladder Kaposi's Sarcoma 9 60
Kaposi's Sarcoma of Palate 9 60
Kaposi's Sarcoma of Cornea 9 60
Kaposi's Sarcoma of Lung 9 60
Kaposi's Sarcoma of Skin 9 60
Cardiac Kaposi's Sarcoma 9 60
Gastric Kaposi's Sarcoma 9 60
Kaposi's Sarcoma of Central Nervous System 9
Central Nervous System Kaposi's Sarcoma 9
Kaposi's Sarcoma of the Gallbladder 9
Kaposi Sarcoma, Susceptibility to 10
Lymphadenopathic Kaposi's Sarcoma 9
Kaposi's Sarcoma of the Prostate 9
Kaposi's Sarcoma of Soft Tissues 9
Kaposi's Sarcoma of Esophagus 9
Conjunctival Kaposi's Sarcoma 9
 
Soft Tissue Kaposi's Sarcoma 9
Esophageal Kaposi's Sarcoma 9
Kaposi's Sarcoma of the Cns 9
Intestinal Kaposi's Sarcoma 9
Lymph Node Kaposi's Sarcoma 9
Cutaneous Kaposi's Sarcoma 9
Pulmonary Kaposi's Sarcoma 9
Kaposi's Sarcoma of Heart 9
Prostate Kaposi's Sarcoma 9
Kaposi's Sarcoma of Penis 9
Esophageal Kaposi Sarcoma 60
Corneal Kaposi's Sarcoma 9
Kaposi's Sarcoma of Anus 9
Prostate Kaposi Sarcoma 60
Palate Kaposi's Sarcoma 9
Kaposi's Sarcoma, Skin 9
Kaposi's Sarcoma, Lung 9
Penis Kaposi's Sarcoma 9
Penile Kaposi Sarcoma 60
Anal Kaposi's Sarcoma 9
Anal Kaposi Sarcoma 60


Classifications:



Characteristics (Orphanet epidemiological data):

47
kaposi's sarcoma:
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe),1-9/100000 (Europe); Age of onset: Adult; Age of death: adult


Related Diseases for Kaposi Sarcoma

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Diseases related to Kaposi Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 145)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma31.9TAT, OSM, CD34, PECAM1
2classic kaposi sarcoma31.9IFNA1, CD34, IL6, TAT
3acquired immunodeficiency syndrome31.4IFNA1, IL6, TAT
4pyogenic granuloma30.8CD34, PECAM1
5arthritis30.7IL6, OSM
6leukopenia30.6IL6, IFNA2, IFNA1
7lymphangioma30.6CD34, PECAM1
8angiosarcoma30.5CD34, PECAM1
9hepatitis30.5IFNA2, TAT, IFNA1, HGF
10malaria30.4TAT, PECAM1
11hepatitis c30.4IL6R, IFNA2, IFNA1
12hemangioma30.2VEGFA, PECAM1, IFNA2, CD34, FGF4
13rheumatoid arthritis29.5VEGFA, OSM, IL6, IL6R, PECAM1, IL6ST
14leukemia29.1IFNA1, OSM, IL6, IFNA2, CD34, FGF4
15endemic kaposi sarcoma10.7
16primary effusion lymphoma10.7
17polyarteritis nodosa10.6IFNA2
18lymphomatoid granulomatosis10.6IFNA2
19panuveitis10.5IFNA2
20inflammatory bowel disease 110.5IL6
21capillary hemangioma10.5CD34
22endotheliitis10.5
23fibrous histiocytoma10.5CD34
24meningioma, familial10.5CD34
25central retinal vein occlusion10.5VEGFA
26hemangioendothelioma10.5CD34, IFNA2
27diabetic macular edema10.5VEGFA
28epithelioid hemangioendothelioma10.4CD34, IFNA2
29castleman's disease10.4
30vascular cancer10.4CD34, IFNA2
31cryoglobulinemia, familial mixed10.4IFNA1, IFNA2
32cryoglobulinemia10.4IFNA1, IFNA2
33hepatitis d10.4IFNA1, IFNA2
34colon kaposi sarcoma10.4
35poems syndrome10.4IL6, VEGFA
36hypothyroidism10.3IFNA2, IFNA1
37sezary's disease10.3IFNA2, IFNA1
38hodgkin lymphoma10.3
39secondary syphilis10.3
40syphilis10.3
41essential thrombocythemia10.3IFNA2, IFNA1
42splenomegaly10.3IFNA1, IFNA2
43thrombocytosis10.3IFNA2, IL6, IFNA1
44factor vii deficiency10.3VEGFA, IFNA2, IFNA1
45neutropenia10.3IFNA2, IFNA1, CD34
46renal cell carcinoma10.3IFNA2, IFNA1, VEGFA
47adrenal hyperplasia, congenital, due to 11-beta-hydroxylase deficiency10.3IFNA2, IFNA1
48multicentric castleman’s disease10.3IL6R, IL6
49acute erythroid leukemia10.3TAT, OSM, IL6ST
50glomerulonephritis10.2

Graphical network of the top 20 diseases related to Kaposi Sarcoma:



Diseases related to kaposi sarcoma

Symptoms for Kaposi Sarcoma

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Symptoms by clinical synopsis from OMIM:

148000

Clinical features from OMIM:

148000

HPO human phenotypes related to Kaposi Sarcoma:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 edema HP:0000969
3 hypermelanotic macule HP:0001034
4 neoplasm HP:0002664

Drugs & Therapeutics for Kaposi Sarcoma

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Genetic Tests for Kaposi Sarcoma

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Anatomical Context for Kaposi Sarcoma

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MalaCards organs/tissues related to Kaposi Sarcoma:

31
Lung, Skin, Prostate, Lymph node, Heart, Endothelial, T cells, B cells, Bone marrow, Bone, Liver, Adrenal gland, Monocytes

Animal Models for Kaposi Sarcoma or affiliated genes

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Publications for Kaposi Sarcoma

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Articles related to Kaposi Sarcoma:

(show top 50)    (show all 244)
idTitleAuthorsYear
1
Concomitant Kaposi sarcoma and multicentric Castleman's disease in a heart transplant recipient. (25169666)
2014
2
Role of IRF4 in IFN-stimulated gene induction and maintenance of Kaposi sarcoma-associated herpesvirus latency in primary effusion lymphoma cells. (23804715)
2013
3
Angiomatous Kaposi Sarcoma: A Variant That Mimics Hemangiomas. (24067801)
2013
4
Isolated oral Kaposi sarcoma in an HIV-negative patient: a case report. (24341128)
2013
5
Iatrogenic colorectal Kaposi sarcoma complicating a refractory ulcerative colitis in a human immunodeficiency negative-virus patient. (24396560)
2013
6
(18)F-FDG PET/CT findings in a case with HIV (-) Kaposi Sarcoma. (24119549)
2013
7
Kaposi sarcoma in an patient with atopic dermatitis treated with ciclosporin. (24265347)
2013
8
Bone marrow findings in HIV-positive patients with Kaposi sarcoma herpesvirus-associated multicentric Castleman disease. (23596117)
2013
9
Tocilizumab Monotherapy in a Patient with Rheumatoid Arthritis and Iatrogenic Kaposi Sarcoma. (24307431)
2013
10
Treatments for classic Kaposi sarcoma: a systematic review of the literature. (22695100)
2013
11
Oral medicine case book 50: HIV associated Kaposi sarcoma. (23971290)
2013
12
Efficacy of 5% imiquimod cream in a patient with classic Kaposi sarcoma. (22826720)
2012
13
Sequence analysis of Kaposi sarcoma-associated herpesvirus (KSHV) microRNAs in patients with multicentric Castleman disease and KSHV-associated inflammatory cytokine syndrome. (22448005)
2012
14
Recent advances in Kaposi sarcoma herpesvirus-associated multicentric Castleman disease. (22729151)
2012
15
Kaposi sarcoma in association with molluscum contagiosum: an uncommon diagnosis in a single biopsy and potential diagnostic pitfall. (22262366)
2012
16
Hsp90 inhibitors are efficacious against Kaposi Sarcoma by enhancing the degradation of the essential viral gene LANA, of the viral co-receptor EphA2 as well as other client proteins. (23209418)
2012
17
High-dose zidovudine plus valganciclovir for Kaposi sarcoma herpesvirus-associated multicentric Castleman disease: a pilot study of virus-activated cytotoxic therapy. (21487108)
2011
18
Delayed-type hypersensitivity in classic Kaposi sarcoma patients and controls. (21245864)
2011
19
Classic Kaposi sarcoma. (21788419)
2011
20
Immune reconstitution and risk of Kaposi sarcoma and non-Hodgkin lymphoma in HIV-infected adults. (21572307)
2011
21
I^-Synuclein is a promising new marker for staining reactive follicular dendritic cells, follicular dendritic cell sarcoma, Kaposi sarcoma, and benign and malignant vascular tumors. (21959308)
2011
22
Pilot study of oral valganciclovir therapy in patients with classic Kaposi sarcoma. (21450998)
2011
23
Paediatric intussusception caused by acquired immunodeficiency syndrome-associated Kaposi sarcoma. (20535484)
2010
24
A case of Kaposi sarcoma-associated herpesvirus/human herpesvirus 8-unrelated but Epstein-Barr virus-positive primary effusion lymphoma-like lymphoma in the setting of human immunodeficiency virus and hepatitis C virus infection. (20929325)
2010
25
Common vascular endothelial growth factor variants and risk for posttransplant Kaposi sarcoma. (20683431)
2010
26
Complex N-linked glycans on Asn-89 of Kaposi sarcoma herpes virus-encoded interleukin-6 mediate optimal function by affecting cytokine protein conformation. (19690161)
2009
27
The role of Ephs, Ephrins, and growth factors in Kaposi sarcoma and implications of EphrinB2 blockade. (18836096)
2009
28
Results of radiation therapy for treatment of classic Kaposi sarcoma. (19298767)
2009
29
Cutaneous tumors, massive lymphadenopathy, and secondary lymphedema in a 16-year-old boy--quiz case. African/endemic Kaposi sarcoma (KS): lymphadenopathic form. (18794470)
2008
30
Pegylated liposomal doxorubicin as second-line therapy in the treatment of patients with advanced classic Kaposi sarcoma: a retrospective study. (18098221)
2008
31
Treatment of classic Kaposi sarcoma with a nicotine dermal patch: a phase II clinical trial. (18384551)
2008
32
Stimulation of c-Myc transcriptional activity by vIRF-3 of Kaposi sarcoma-associated herpesvirus. (17728244)
2007
33
Relationship between human herpesvirus 8 loads and disease stage in classic Kaposi sarcoma patients. (17403447)
2007
34
Conservation of virally encoded microRNAs in Kaposi sarcoma--associated herpesvirus in primary effusion lymphoma cell lines and in patients with Kaposi sarcoma or multicentric Castleman disease. (17262705)
2007
35
Influence of HLA alleles on shedding of Kaposi sarcoma-associated herpesvirus in saliva in an African population. (17299710)
2007
36
Rapidly progressive classic Kaposi sarcoma in an adolescent: response to interferon alfa therapy and biological correlates. (16445793)
2006
37
Activation of Src kinase Lyn by the Kaposi sarcoma-associated herpesvirus K1 protein: implications for lymphomagenesis. (15665117)
2005
38
Regulation of microfilament organization by Kaposi sarcoma-associated herpes virus-cyclin.CDK6 phosphorylation of caldesmon. (16115893)
2005
39
Ephrin B2 expression in Kaposi sarcoma is induced by human herpesvirus type 8: phenotype switch from venous to arterial endothelium. (15471957)
2005
40
Mono/oligoclonal pattern of Kaposi Sarcoma-associated herpesvirus (KSHV/HHV-8) episomes in primary effusion lymphoma cells. (15700304)
2005
41
Kaposi sarcoma-associated herpesvirus (KSHV) induces heme oxygenase-1 expression and activity in KSHV-infected endothelial cells. (14726403)
2004
42
Selective expression of stromal-derived factor-1 in the capillary vascular endothelium plays a role in Kaposi sarcoma pathogenesis. (12907452)
2003
43
The Kaposi sarcoma-associated herpesvirus (KSHV) induces cellular interleukin 6 expression: role of the KSHV latency-associated nuclear antigen and the AP1 response element. (11781250)
2002
44
Lytic replication-associated protein (RAP) encoded by Kaposi sarcoma-associated herpesvirus causes p21CIP-1-mediated G1 cell cycle arrest through CCAAT/enhancer-binding protein-alpha. (12145325)
2002
45
Receptor engagement by viral interleukin-6 encoded by Kaposi sarcoma-associated herpesvirus. (11698289)
2001
46
Long-term remission of Kaposi sarcoma-associated herpesvirus-related multicentric Castleman disease with anti-CD20 monoclonal antibody therapy. (11719390)
2001
47
A single 13-kilobase divergent locus in the Kaposi sarcoma-associated herpesvirus (human herpesvirus 8) genome contains nine open reading frames that are homologous to or related to cellular proteins. (9032328)
1997
48
Human herpesvirus 8 in classic Kaposi sarcoma. (9147730)
1996
49
The detection of acquired immunodeficiency syndrome-associated Kaposi sarcoma cells in pleural effusion by CD34 immunostain. (7690682)
1993
50
Intralesional treatment of classical Kaposi sarcoma with interferon-alpha]. (1361927)
1992

Variations for Kaposi Sarcoma

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Expression for genes affiliated with Kaposi Sarcoma

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Search GEO for disease gene expression data for Kaposi Sarcoma.

Pathways for genes affiliated with Kaposi Sarcoma

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Pathways related to Kaposi Sarcoma according to GeneCards Suite gene sharing:

(show all 48)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8IL6, HGF, PECAM1
29.8IL6R, IL6, VEGFA
39.8IL6R, VEGFA, IL6
4
Show member pathways
9.7HGF, PECAM1, VEGFA
5
Show member pathways
9.6FGF5, FGF4
6
Show member pathways
9.6IL6, IL6ST, IL6R
79.6IL6ST, IL6, IL6R
89.6IL6, IL6R, IL6ST
99.6IL6, IL6R, IL6ST
109.6IL6, IL6R, IL6ST
11
Show member pathways
Translation Non genomic rapid action of Androgen Receptor58
9.6IL6R, IL6, IL6ST
12
Show member pathways
9.6IL6ST, IL6R, IL6
13
Show member pathways
9.6IL6ST, IL6R, IL6
149.5IL6, CD34, IL6R
159.5IFNA1, IFNA2, IL6
169.5IFNA2, IL6, IFNA1
179.5IL6, IFNA2, IFNA1
18
Show member pathways
9.5IFNA2, IL6, IFNA1
199.5OSM, IL6, IL6ST
209.5OSM, IL6ST, VEGFA
21
Show member pathways
9.4IL6ST, IL6, IL6R, HGF
22
Show member pathways
9.4FGF3, FGF5, FGF4
23
Show member pathways
9.4FGF3, FGF4, FGF5
24
Show member pathways
9.4FGF3, FGF5, FGF4
25
Show member pathways
9.4FGF4, FGF3, FGF5
26
Show member pathways
9.2IL6, FGF5, FGF4, HGF
27
Show member pathways
9.2FGF5, FGF4, HGF, IL6
28
Show member pathways
9.2HGF, IL6, FGF5, FGF4
29
Show member pathways
9.2HGF, IL6, FGF5, FGF4
30
Show member pathways
9.2FGF5, IL6, HGF, FGF4
31
Show member pathways
9.2STIM1, FGF4, FGF3, FGF5
32
Show member pathways
9.1FGF5, CYSLTR2, FGF4, FGF3
33
Show member pathways
9.0IL6, FGF5, FGF4, HGF, FGF3
34
Show member pathways
Signaling Pathways in Glioblastoma36
8.9FGF5, FGF3, FGF4, HGF, VEGFA
358.9FGF3, FGF4, FGF5, HGF, VEGFA
36
Show member pathways
8.9FGF5, HGF, VEGFA, FGF4, FGF3
37
Show member pathways
8.9FGF5, FGF4, HGF, IL6, IL6ST
388.7HGF, FGF3, FGF5, VEGFA, FGF4, IL6
39
Show member pathways
8.7FGF5, FGF3, CD34, FGF4, STIM1
40
Show member pathways
8.7IFNA2, IL6, HGF, IL6ST, IFNA1, IL6R
41
Show member pathways
Type III interferon signaling36
8.5OSM, IFNA1, IFNA2, IL6ST, IL6, IL6R
42
Show member pathways
8.4STIM1, IFNA1, SLC7A11, HGF, VEGFA, PECAM1
43
Show member pathways
7.9FGF4, FGF3, IFNA1, FGF5, IFNA2, IL6
44
Show member pathways
7.7OSM, CCR8, IL6, IL6R, HGF, FGF4
45
Show member pathways
7.7CCR8, IL6, IL6R, HGF, FGF4, FGF5
46
Show member pathways
7.7HGF, FGF4, IL6, FGF5, CCR8, IL6R
477.3VEGFA, OSM, IFNA1, IFNA2, IL6, IL6R
48
Show member pathways
7.2VEGFA, OSM, CCR8, IFNA1, HGF, IL6R

Compounds for genes affiliated with Kaposi Sarcoma

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Compounds related to Kaposi Sarcoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 103)
idCompoundScoreTop Affiliating Genes
1tocilizumab43 1211.2IL6R, IL6
2pegasys4310.0IFNA2, IFNA1
3entecavir439.9IFNA1, IFNA2
4filgrastim43 1210.9HGF, OSM, IL6, IFNA2
5imiquimod43 59 28 1212.9IL6, IFNA1, IFNA2
6temozolomide43 1210.8IFNA1, VEGFA, IFNA2
7isotretinoin43 1210.8IFNA2, IFNA1, HGF
8suramin43 28 1211.8VEGFA, HGF, IL6R, FGF4
9ursodeoxycholic acid43 24 1211.7HGF, IFNA2, IFNA1
10infliximab43 49 1211.7VEGFA, IFNA2, IL6
11prostacyclin439.7CYSLTR2, HGF, VEGFA, PECAM1
122,5-oligoadenylate439.7TAT, IL6, IFNA2, IFNA1
13hyaluronic acid43 2410.7VEGFA, HGF, IL6, OSM
14neopterin439.6IFNA1, IFNA2, IL6, IL6R
15rituximab43 49 1211.6IL6, IL6R, IFNA1, IFNA2
16methotrexate49 43 1211.6TAT, IL6, HGF, IL6R
17tgf beta1439.6OSM, IL6, HGF, FGF4
18leucovorin43 49 1211.6IFNA2, IFNA1, VEGFA
19indomethacin43 28 59 1212.6TAT, HGF, IFNA2, OSM, IL6
20gp 130439.6IL6ST, IL6R, IL6, OSM
21cyclophosphamide43 49 1211.5IFNA2, VEGFA, HGF, IFNA1
22acth439.4IL6, IL6ST, IFNA2, OSM, CYSLTR2
23fibrinogen439.4PECAM1, OSM, IL6, IL6R, TAT
24matrigel439.4FGF4, PECAM1, VEGFA, OSM, HGF
255fluorouracil439.3IFNA2, VEGFA, HGF, IFNA1
26thalidomide43 49 59 1212.3IFNA1, VEGFA, IL6R, IFNA2, IL6, HGF
27genistein43 28 59 2 24 1214.2VEGFA, IL6, OSM, IL6ST, HGF, TAT
28actinomycin d439.2IFNA1, IL6, TAT, PECAM1, HGF, VEGFA
29cyclosporin a43 28 5911.1TAT, HGF, IL6R, IL6, IFNA1, PECAM1
30ccl343 2810.1IFNA1, TAT, IL6, CCR8
31oxygen43 249.9TAT, HGF, IFNA2, CYSLTR2, PECAM1, SLC7A11
32pge2438.9HGF, IL6R, CYSLTR2, OSM, VEGFA, IL6
33glucose438.9IL6R, TAT, FGF4, IFNA2, PECAM1, IL6
34retinoid438.9IFNA1, IFNA2, HGF, FGF4
35ifn-alpha438.9IL6, IL6ST, IFNA2, IFNA1, IL6R, OSM
36cholesterol43 28 24 1211.9IL6ST, IL6, IL6R, PECAM1, OSM, FGF4
37prednisolone43 28 1210.9IL6, IFNA2, IL6ST, IFNA1, IL6R, TAT
38histamine43 28 2410.8OSM, TAT, IL6, HGF, IL6R, PECAM1
39alanine438.7OSM, IFNA1, IFNA2, IL6ST, IL6, HGF
40heparin43 28 24 1211.6FGF5, FGF4, FGF3, PECAM1, CYSLTR2, VEGFA
41dexamethasone43 49 28 1211.4VEGFA, TAT, HGF, IL6R, IL6, IL6ST
42lipid438.4PECAM1, CYSLTR2, OSM, TAT, IFNA2, IL6ST
43cycloheximide438.2PECAM1, VEGFA, IL6ST, IFNA1, HGF, IL6
44agar438.1TAT, CD34, FGF4, FGF3, PECAM1, HGF
45rantes438.1IL6, IFNA1, PECAM1, OSM, CCR8, TAT
46estrogen438.0IFNA2, VEGFA, PECAM1, OSM, FGF4, IL6ST
47thymidine43 248.8FGF5, IL6, PECAM1, HGF, IL6R, CD34
48retinoic acid43 248.4IL6R, HGF, TAT, CD34, IL6, IL6ST
49tyrosine436.4IL6, IFNA2, IFNA1, OSM, VEGFA, CYSLTR2
50vegf436.1IFNA1, TAT, IL6R, FGF4, FGF3, FGF5

GO Terms for genes affiliated with Kaposi Sarcoma

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Cellular components related to Kaposi Sarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1oncostatin-M receptor complexGO:00059009.7IL6ST, OSM
2interleukin-6 receptor complexGO:00058969.5IL6ST, IL6, IL6R
3extracellular spaceGO:00056157.7FGF5, PECAM1, VEGFA, OSM, IFNA2, IL6ST
4extracellular regionGO:00055767.6VEGFA, IFNA2, IL6ST, IL6, IL6R, HGF

Biological processes related to Kaposi Sarcoma according to GeneCards Suite gene sharing:

(show all 36)
idNameGO IDScoreTop Affiliating Genes
1hepatic immune responseGO:000238410.4IL6R, IL6
2negative regulation of collagen biosynthetic processGO:003296610.4IL6R, IL6
3neutrophil mediated immunityGO:000244610.3IL6, IL6R
4positive regulation of leukocyte chemotaxisGO:000269010.3IL6R, IL6
5negative regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:004315410.2VEGFA, IL6, HGF
6ciliary neurotrophic factor-mediated signaling pathwayGO:007012010.2IL6R, IL6ST
7positive regulation of chemokine productionGO:003272210.1IL6R, IL6
8negative regulation of hormone secretionGO:004688810.1IL6, OSM
9negative regulation of neuron deathGO:0190121510.1CD34, IL6
10monocyte chemotaxisGO:000254810.1IL6, IL6R
11glomerular endothelium developmentGO:007201110.1CD34, PECAM1
12platelet degranulationGO:000257610.0HGF, VEGFA, PECAM1
13positive chemotaxisGO:005091810.0HGF, VEGFA
14interleukin-6-mediated signaling pathwayGO:007010210.0IL6ST, IL6, IL6R
15positive regulation of peptidyl-serine phosphorylationGO:003313810.0IL6, OSM, VEGFA
16glutamate metabolic processGO:000653610.0TAT, CD34
17positive regulation of ERK1 and ERK2 cascadeGO:00703749.9CYSLTR2, IL6, FGF4
18positive regulation of MAPK cascadeGO:00434109.9OSM, IL6, IL6R
19platelet activationGO:00301689.9PECAM1, VEGFA, IL6, HGF
20positive regulation of acute inflammatory responseGO:00026759.9IL6, IL6ST, OSM
21positive regulation of angiogenesisGO:00457669.8CYSLTR2, VEGFA, CD34
22positive regulation of osteoblast differentiationGO:00456699.8IL6ST, IL6, IL6R, HGF
23positive regulation of tyrosine phosphorylation of Stat3 proteinGO:00425179.8IL6R, IL6, IL6ST, IFNA2
24cytokine-mediated signaling pathwayGO:00192219.7IFNA2, IL6ST, IL6, IL6R
25defense response to Gram-negative bacteriumGO:00508299.7IL6R, IL6
26positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.6VEGFA, OSM, IL6, IL6R, HGF
27leukocyte migrationGO:00509009.6SLC7A11, CD34, PECAM1
28negative regulation of apoptotic processGO:00430669.5VEGFA, IL6ST, IL6, HGF, FGF4
29cell-cell signalingGO:00072679.5FGF5, FGF3, FGF4, IFNA2
30phosphatidylinositol-mediated signalingGO:00480159.4FGF5, FGF3, FGF4
31insulin receptor signaling pathwayGO:00082869.4FGF5, FGF3, FGF4
32blood coagulationGO:00075969.4PECAM1, VEGFA, STIM1, IFNA2, HGF, SLC7A11
33positive regulation of transcription from RNA polymerase II promoterGO:00459449.3FGF4, HGF, IL6, OSM, VEGFA
34fibroblast growth factor receptor signaling pathwayGO:00085439.3FGF4, FGF3, FGF5
35positive regulation of cell divisionGO:00517819.1VEGFA, OSM, FGF4, FGF3, FGF5
36positive regulation of cell proliferationGO:00082848.3FGF5, VEGFA, OSM, IL6ST, IL6, IL6R

Molecular functions related to Kaposi Sarcoma according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1chemoattractant activityGO:004205610.0HGF, VEGFA
2interleukin-6 bindingGO:00199819.9IL6ST, IL6R
3interleukin-6 receptor activityGO:00049159.9IL6ST, IL6R
4interleukin-6 receptor bindingGO:00051389.8IL6ST, IL6, IL6R
5ciliary neurotrophic factor receptor activityGO:00048979.7IL6R, IL6ST
6fibroblast growth factor receptor bindingGO:00051049.5FGF5, FGF3, FGF4
7cytokine activityGO:00051259.4VEGFA, OSM, IFNA2, IL6
8growth factor activityGO:00080838.5FGF5, FGF3, FGF4, HGF, IL6, OSM
9protein bindingGO:00055156.9PECAM1, VEGFA, STIM1, CCNK, IFNA2, IL6ST

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
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35MGI
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60UMLS
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